acetaminophen has been researched along with Rhabdomyolysis in 19 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Rhabdomyolysis: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of the 345 patients included in the study, elevated AST/ALT levels were attributed to rhabdomyolysis in 168 patients and attributed to acetaminophen toxicity in 177 patients." | 8.02 | Patterns of transaminase elevation in rhabdomyolysis versus acetaminophen toxicity. ( Maskell, KF; Okhomina, V; Powell, SW; Sima, AP; Willis, D; Wills, BK, 2021) |
| "Rhabdomyolysis and delayed acetaminophen hepatotoxicity may be associated with elevated serum transaminase values." | 7.88 | Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis. ( Albertson, TE; Algren, DA; Chenoweth, JA; Ford, JB; Owen, KP; Radke, JB; Sutter, ME, 2018) |
| " We describe considerations of concurrent buprenorphine/naloxone therapy during episodes of severe acute pain." | 7.79 | Acute pain control challenges with buprenorphine/naloxone therapy in a patient with compartment syndrome secondary to McArdle's disease: a case report and review. ( Chang-Chien, GC; Chu, SK; Joseph, P; McCormick, Z, 2013) |
| "A 28-year-old man with schizophrenia intentionally ingested a lethal dose of acetaminophen and an unknown quantity of ibuprofen." | 7.74 | Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose. ( Dunn, T; Katz, D; Nelson, H; Singh, G; Thomsen, D; Voigt, M; Whitaker, E, 2007) |
| " Although her consciousness and hemodynamic status gradually improved after treatment with N-acetylcysteine and other supportive measures, she was found to have pancytopenia, pancreatitis and hepatorenal failure during the hospitalization and eventually died 18 d post-admission." | 7.71 | Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. ( Deng, JF; Lin, TJ; Yang, CC, 2001) |
| "Rhabdomyolysis is an important cause of acute renal failure (ARF) and renal vasoconstriction is the main mechanism in the pathogenesis of ARF." | 5.38 | Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical. ( Cil, O; Ertunc, M; Gucer, KS; Iskit, AB; Onur, R; Ozaltin, F, 2012) |
| "Of the 345 patients included in the study, elevated AST/ALT levels were attributed to rhabdomyolysis in 168 patients and attributed to acetaminophen toxicity in 177 patients." | 4.02 | Patterns of transaminase elevation in rhabdomyolysis versus acetaminophen toxicity. ( Maskell, KF; Okhomina, V; Powell, SW; Sima, AP; Willis, D; Wills, BK, 2021) |
| "Rhabdomyolysis and delayed acetaminophen hepatotoxicity may be associated with elevated serum transaminase values." | 3.88 | Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis. ( Albertson, TE; Algren, DA; Chenoweth, JA; Ford, JB; Owen, KP; Radke, JB; Sutter, ME, 2018) |
| " We describe considerations of concurrent buprenorphine/naloxone therapy during episodes of severe acute pain." | 3.79 | Acute pain control challenges with buprenorphine/naloxone therapy in a patient with compartment syndrome secondary to McArdle's disease: a case report and review. ( Chang-Chien, GC; Chu, SK; Joseph, P; McCormick, Z, 2013) |
| "A 28-year-old man with schizophrenia intentionally ingested a lethal dose of acetaminophen and an unknown quantity of ibuprofen." | 3.74 | Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose. ( Dunn, T; Katz, D; Nelson, H; Singh, G; Thomsen, D; Voigt, M; Whitaker, E, 2007) |
| " Although her consciousness and hemodynamic status gradually improved after treatment with N-acetylcysteine and other supportive measures, she was found to have pancytopenia, pancreatitis and hepatorenal failure during the hospitalization and eventually died 18 d post-admission." | 3.71 | Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. ( Deng, JF; Lin, TJ; Yang, CC, 2001) |
| "Rhabdomyolysis-induced renal failure represents up to 15% of all cases of acute renal failure." | 2.47 | Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure. ( Boutaud, O; Roberts, LJ, 2011) |
| "Acetaminophen or paracetamol, a commonly used over-the-counter analgesic, is known to elicit severe adverse reactions when taken in overdose, chronically at therapeutic dosage or, sporadically, following single assumptions of a therapeutic dose." | 1.39 | Possible fatal acetaminophen intoxication with atypical clinical presentation. ( Carbone, A; Chiarotti, M; d'Aloja, E; De-Giorgio, F; Lodise, M; Valerio, L, 2013) |
| "Rhabdomyolysis is an important cause of acute renal failure (ARF) and renal vasoconstriction is the main mechanism in the pathogenesis of ARF." | 1.38 | Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical. ( Cil, O; Ertunc, M; Gucer, KS; Iskit, AB; Onur, R; Ozaltin, F, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 7 (36.84) | 24.3611 |
| 2020's | 4 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Finsterer, J | 1 |
| Schomaker, S | 1 |
| Potter, D | 1 |
| Warner, R | 1 |
| Larkindale, J | 1 |
| King, N | 1 |
| Porter, AC | 1 |
| Owens, J | 1 |
| Tomlinson, L | 1 |
| Sauer, JM | 1 |
| Johnson, K | 1 |
| Aubrecht, J | 1 |
| Maskell, KF | 1 |
| Powell, SW | 1 |
| Willis, D | 1 |
| Okhomina, V | 1 |
| Sima, AP | 1 |
| Wills, BK | 1 |
| Desgrouas, M | 1 |
| Boulain, T | 1 |
| Radke, JB | 1 |
| Algren, DA | 1 |
| Chenoweth, JA | 1 |
| Owen, KP | 1 |
| Ford, JB | 1 |
| Albertson, TE | 1 |
| Sutter, ME | 1 |
| McCormick, Z | 1 |
| Chu, SK | 1 |
| Chang-Chien, GC | 1 |
| Joseph, P | 1 |
| De-Giorgio, F | 1 |
| Lodise, M | 1 |
| Chiarotti, M | 1 |
| d'Aloja, E | 1 |
| Carbone, A | 1 |
| Valerio, L | 1 |
| Boutaud, O | 2 |
| Moore, KP | 1 |
| Reeder, BJ | 1 |
| Harry, D | 1 |
| Howie, AJ | 1 |
| Wang, S | 1 |
| Carney, CK | 1 |
| Masterson, TS | 1 |
| Amin, T | 1 |
| Wright, DW | 1 |
| Wilson, MT | 1 |
| Oates, JA | 1 |
| Roberts, LJ | 2 |
| Chen, SC | 1 |
| Liu, KS | 1 |
| Chang, HR | 1 |
| Lee, YT | 1 |
| Chen, CC | 1 |
| Lee, MC | 1 |
| Cil, O | 1 |
| Ertunc, M | 1 |
| Gucer, KS | 1 |
| Ozaltin, F | 1 |
| Iskit, AB | 1 |
| Onur, R | 1 |
| Giles, FJ | 1 |
| Cortes, JE | 1 |
| Halliburton, TA | 1 |
| Mallard, SJ | 1 |
| Estey, EH | 1 |
| Waddelow, TA | 1 |
| Lim, JT | 1 |
| Nelson, H | 1 |
| Katz, D | 1 |
| Dunn, T | 1 |
| Singh, G | 1 |
| Voigt, M | 1 |
| Whitaker, E | 1 |
| Thomsen, D | 1 |
| Rees, GW | 1 |
| Trull, AK | 1 |
| Doyle, S | 1 |
| Riggs, JE | 1 |
| Schochet, SS | 1 |
| Parmar, JP | 1 |
| Moneret-Vautrin, DA | 1 |
| Morisset, M | 1 |
| Humbert, JC | 1 |
| Beaudouin, E | 1 |
| Tupin, N | 1 |
| Plantier, L | 1 |
| Yang, CC | 1 |
| Deng, JF | 1 |
| Lin, TJ | 1 |
| Michaelis, HC | 1 |
| Sharifi, S | 1 |
| Schoel, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Randomized Trial of the Effect of Standard of Care Reduced Dose Versus Full Dose Buprenorphine/Naloxone in the Perioperative Period on Pain Control and Post Operative Opioid Use Disorder Symptoms[NCT03266445] | Phase 4 | 76 participants (Anticipated) | Interventional | 2018-10-05 | Not yet recruiting | ||
| Does Preoperative Acetaminophen Reduce Biochemical Markers of Oxidative Stress From Cardiopulmonary Bypass?[NCT01228305] | 30 participants (Actual) | Interventional | 2011-07-31 | Completed | |||
| Inhibition of Lipid Peroxidation During Cardiopulmonary Bypass[NCT01366976] | 67 participants (Actual) | Interventional | 2011-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Plasma F2-isoprostane concentrations as a measure of lipid peroxidation (NCT01366976)
Timeframe: 24 hours
| Intervention | pg/mL (Mean) | |||||
|---|---|---|---|---|---|---|
| baseline | 30min of bypass | 60min of bypass | post-bypass | ICU | postoperative day 1 | |
| Acetaminophen | 27.8 | 45.8 | 52.0 | 34 | 32.0 | 26.5 |
| Placebo | 30.6 | 49.1 | 52.8 | 48.4 | 47.5 | 26.0 |
Plasma isofuran concentrations as a measure of lipid peroxidation (NCT01366976)
Timeframe: 24 hours
| Intervention | pg/mL (Mean) | |||||
|---|---|---|---|---|---|---|
| baseline | 30min of bypass | 60min of bypass | post-bypass | ICU | postoperative day 1 | |
| Acetaminophen | 61.5 | 72.1 | 83.4 | 82.9 | 85.3 | 70.4 |
| Placebo | 67.7 | 82.7 | 110.8 | 96.1 | 88.0 | 68.5 |
Serum creatinine measured over a 72 hour period (NCT01366976)
Timeframe: 72 hours
| Intervention | mg/dL (Mean) | |||
|---|---|---|---|---|
| baseline | postoperative day 1 | postoperative day 2 | postoperative day 3 | |
| Acetaminophen | 0.98 | 0.89 | 0.96 | 0.93 |
| Placebo | 0.94 | 0.90 | 0.96 | 0.88 |
Changes in urinary NGAL (neutrophil gelatinase-associated lipocalin) as marker of acute kidney injury (NCT01366976)
Timeframe: 24 hours
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| baseline | pos-bypass | postoperative day 1 | |
| Acetaminophen | 19.21 | 145.8 | 46.04 |
| Placebo | 23.2 | 138.4 | 16.8 |
1 review available for acetaminophen and Rhabdomyolysis
| Article | Year |
|---|---|
Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure.
Topics: Acetaminophen; Animals; Disease Models, Animal; Humans; Hydrogen Peroxide; Iron; Kidney; Lipid Perox | 2011 |
1 trial available for acetaminophen and Rhabdomyolysis
| Article | Year |
|---|---|
Intravenous corticosteroids to reduce gemtuzumab ozogamicin infusion reactions.
Topics: Acetaminophen; Adult; Aminoglycosides; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflamm | 2003 |
17 other studies available for acetaminophen and Rhabdomyolysis
| Article | Year |
|---|---|
Letter to the Editor: Propacetamol-Induced Rhabdomyolysis or COVID-Vaccine-Related Inflammatory Myopathy?
Topics: Acetaminophen; BNT162 Vaccine; COVID-19; COVID-19 Vaccines; Humans; Myositis; Rhabdomyolysis; Vaccin | 2022 |
Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments.
Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomar | 2020 |
Patterns of transaminase elevation in rhabdomyolysis versus acetaminophen toxicity.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Diagnosis, Diff | 2021 |
Paracetamol use and lowered risk of acute kidney injury in patients with rhabdomyolysis.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Cohort Studies; Humans; Mice; Renal Replacement Therapy | 2021 |
Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis.
Topics: Acetaminophen; Adult; Creatine Kinase; Diagnosis, Differential; Drug Overdose; Female; Humans; Male; | 2018 |
Acute pain control challenges with buprenorphine/naloxone therapy in a patient with compartment syndrome secondary to McArdle's disease: a case report and review.
Topics: Acetaminophen; Acute Pain; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio | 2013 |
Possible fatal acetaminophen intoxication with atypical clinical presentation.
Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Disseminated Intravascular Coagulation | 2013 |
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure.
Topics: Acetaminophen; Animals; Arachidonic Acids; Catalysis; Dose-Response Relationship, Drug; Hemeproteins | 2010 |
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure.
Topics: Acetaminophen; Animals; Arachidonic Acids; Catalysis; Dose-Response Relationship, Drug; Hemeproteins | 2010 |
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure.
Topics: Acetaminophen; Animals; Arachidonic Acids; Catalysis; Dose-Response Relationship, Drug; Hemeproteins | 2010 |
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure.
Topics: Acetaminophen; Animals; Arachidonic Acids; Catalysis; Dose-Response Relationship, Drug; Hemeproteins | 2010 |
Rhabdomyolysis following pandemic influenza A (H1N1) infection.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Antiviral Agents; Asparta | 2010 |
Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Electric Stimulation; Endothelium, Vascular; Female; Fr | 2012 |
Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Chemical Analysis; Drug Overdose; Humans; Ibup | 2007 |
Dihydrocodeine overdose treated with naloxone infusion.
Topics: Acetaminophen; Aged; Codeine; Dextropropoxyphene; Drug Combinations; Female; Humans; Male; Middle Ag | 1983 |
Evaluation of an enzyme-immunometric assay for serum alpha-glutathione S-transferase.
Topics: Acetaminophen; Alkaline Phosphatase; Analgesics, Non-Narcotic; Analysis of Variance; Arthritis, Rheu | 1995 |
Rhabdomyolysis with acute renal failure and disseminated intravascular coagulation: association with acetaminophen and ethanol.
Topics: Acetaminophen; Acute Kidney Injury; Alcohol Drinking; Disseminated Intravascular Coagulation; Ethano | 1996 |
Acetaminophen-induced rhabdomyolysis.
Topics: Acetaminophen; Adolescent; Drug Hypersensitivity; Humans; Male; Rhabdomyolysis | 1999 |
Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Coma; Diagnosis, Diff | 2001 |
Rhabdomyolysis after suicidal ingestion of an overdose of caffeine, acetaminophen and phenazone as a fixed-dose combination (Spalt N).
Topics: Acetaminophen; Adult; Antipyrine; Caffeine; Creatine Kinase; Drug Combinations; Drug Overdose; Human | 1991 |