acetaminophen has been researched along with Renal Insufficiency in 21 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal insufficiency is less common than liver failure in acetaminophen overdose but renal tubular damage occurs even in the absence of hepatotoxicity." | 7.73 | Experiences of a poison center network with renal insufficiency in acetaminophen overdose: an analysis of 17 cases. ( Hengstler, JG; Hermanns-Clausen, M; Kaes, J; Koch, I; Lauterbach, M; von Mach, MA; Weilemann, LS, 2005) |
| " Although her consciousness and hemodynamic status gradually improved after treatment with N-acetylcysteine and other supportive measures, she was found to have pancytopenia, pancreatitis and hepatorenal failure during the hospitalization and eventually died 18 d post-admission." | 7.71 | Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. ( Deng, JF; Lin, TJ; Yang, CC, 2001) |
| "Renal insufficiency is less common than liver failure in acetaminophen overdose but renal tubular damage occurs even in the absence of hepatotoxicity." | 3.73 | Experiences of a poison center network with renal insufficiency in acetaminophen overdose: an analysis of 17 cases. ( Hengstler, JG; Hermanns-Clausen, M; Kaes, J; Koch, I; Lauterbach, M; von Mach, MA; Weilemann, LS, 2005) |
| " Although her consciousness and hemodynamic status gradually improved after treatment with N-acetylcysteine and other supportive measures, she was found to have pancytopenia, pancreatitis and hepatorenal failure during the hospitalization and eventually died 18 d post-admission." | 3.71 | Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. ( Deng, JF; Lin, TJ; Yang, CC, 2001) |
| " Like every other drug(s), APAP also undergo metabolism by oxidation or conjugation by glucuronate and sulphate to form the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI)." | 2.82 | Protective effect of probiotics against acetaminophen induced nephrotoxicity. ( Dua, TK; Palai, S; Paul, P; Roy, A, 2022) |
| "Rhabdomyolysis-induced renal failure represents up to 15% of all cases of acute renal failure." | 2.47 | Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure. ( Boutaud, O; Roberts, LJ, 2011) |
| "Acetaminophen (paracetamol) is a widely used drug and known as a safety antipyretic and analgesic drug in childhood." | 2.46 | A case of acetaminophen (paracetamol) causing renal failure without liver damage in a child and review of literature. ( Bek, K; Genc, G; Ozkaya, O; Sullu, Y, 2010) |
| "We wondered whether renal failure would affect APAP-CYS elimination half-life and whether continuous venovenous hemodiafiltration (CVVHDF), commonly used in liver failure patients, would remove adducts to lower their serum concentrations." | 1.42 | Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose. ( Bikin, DS; Curry, SC; Gerkin, RD; O'Connor, AD; Padilla-Jones, A; Rollins, DE; Ruha, AM; Slawson, MH; Wilkins, DG, 2015) |
| "Chronic kidney disease, end-stage renal failure, and liver diseases are increasing worldwide and constitute a huge burden on health care costs, with attendant high morbidity and debility." | 1.40 | Hepato- and nephroprotective activities of a Nigerian local king tuber oyster mushroom, Pleurotus tuberregium (higher Basidiomycetes), in chemically induced organ toxicities in rats. ( Akah, PA; Ihim, SA; Laiyemo, KA; Nworu, CS; Ugwu, LE, 2014) |
| "In addition to hepatic dysfunction, renal failure and disseminated intravascular coagulopathy, we should pay attention to various symptoms like in this case when treating for a acetaminophen poisoning." | 1.33 | [Case report of repeated acetaminophen overdosing with various symptoms]. ( Inagawa, H; Ishida, J; Kojima, N; Machida, M; Okada, Y; Terada, T, 2006) |
| "The reported incidence of renal failure in unselected patients with paracetamol poisoning is about 1-2%." | 1.29 | Renal failure is uncommon in Chinese patients with paracetamol (acetaminophen) poisoning. ( Chan, AY; Chan, TY; Critchley, JA, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 7 (33.33) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Dua, TK | 1 |
| Palai, S | 1 |
| Roy, A | 1 |
| Paul, P | 1 |
| Rajaram, P | 1 |
| Subramanian, R | 1 |
| Le Vaillant, J | 1 |
| Pellerin, L | 1 |
| Brouard, J | 1 |
| Eckart, P | 1 |
| Nworu, CS | 1 |
| Ihim, SA | 1 |
| Ugwu, LE | 1 |
| Laiyemo, KA | 1 |
| Akah, PA | 1 |
| Curry, SC | 1 |
| Padilla-Jones, A | 1 |
| O'Connor, AD | 1 |
| Ruha, AM | 1 |
| Bikin, DS | 1 |
| Wilkins, DG | 1 |
| Rollins, DE | 1 |
| Slawson, MH | 1 |
| Gerkin, RD | 1 |
| Manakkat Vijay, GK | 1 |
| Kronsten, VT | 1 |
| Bain, BJ | 1 |
| Shawcross, DL | 1 |
| Phadke, G | 1 |
| Mahale, A | 1 |
| Chemiti, G | 1 |
| Levitski, T | 1 |
| Ahlin, T | 1 |
| Mistry, B | 1 |
| Boutaud, O | 2 |
| Moore, KP | 1 |
| Reeder, BJ | 1 |
| Harry, D | 1 |
| Howie, AJ | 1 |
| Wang, S | 1 |
| Carney, CK | 1 |
| Masterson, TS | 1 |
| Amin, T | 1 |
| Wright, DW | 1 |
| Wilson, MT | 1 |
| Oates, JA | 1 |
| Roberts, LJ | 2 |
| Ozkaya, O | 1 |
| Genc, G | 1 |
| Bek, K | 1 |
| Sullu, Y | 1 |
| Anthony, OE | 1 |
| Mbuh, AF | 1 |
| Emmanuel, MP | 1 |
| Ng, KL | 1 |
| Davidson, JS | 1 |
| Bathgate, AJ | 1 |
| Adams, MW | 1 |
| Chrispin, P | 1 |
| Spice, M | 1 |
| von Mach, MA | 1 |
| Hermanns-Clausen, M | 1 |
| Koch, I | 1 |
| Hengstler, JG | 1 |
| Lauterbach, M | 1 |
| Kaes, J | 1 |
| Weilemann, LS | 1 |
| Kojima, N | 1 |
| Ishida, J | 1 |
| Inagawa, H | 1 |
| Okada, Y | 1 |
| Machida, M | 1 |
| Terada, T | 1 |
| Chan, TY | 1 |
| Critchley, JA | 1 |
| Chan, AY | 1 |
| Bonkovsky, HL | 1 |
| Kane, RE | 1 |
| Jones, DP | 1 |
| Galinsky, RE | 1 |
| Banner, B | 1 |
| Gleiter, CH | 1 |
| Bernal, W | 1 |
| Wendon, J | 1 |
| Rexrode, KM | 1 |
| Buring, JE | 1 |
| Glynn, RJ | 1 |
| Stampfer, MJ | 1 |
| Youngman, LD | 1 |
| Gaziano, JM | 1 |
| Yang, CC | 1 |
| Deng, JF | 1 |
| Lin, TJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Preoperative Acetaminophen Reduce Biochemical Markers of Oxidative Stress From Cardiopulmonary Bypass?[NCT01228305] | 30 participants (Actual) | Interventional | 2011-07-31 | Completed | |||
| Inhibition of Lipid Peroxidation During Cardiopulmonary Bypass[NCT01366976] | 67 participants (Actual) | Interventional | 2011-07-31 | Completed | |||
| [NCT00000500] | Phase 3 | 0 participants | Interventional | 1981-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Plasma F2-isoprostane concentrations as a measure of lipid peroxidation (NCT01366976)
Timeframe: 24 hours
| Intervention | pg/mL (Mean) | |||||
|---|---|---|---|---|---|---|
| baseline | 30min of bypass | 60min of bypass | post-bypass | ICU | postoperative day 1 | |
| Acetaminophen | 27.8 | 45.8 | 52.0 | 34 | 32.0 | 26.5 |
| Placebo | 30.6 | 49.1 | 52.8 | 48.4 | 47.5 | 26.0 |
Plasma isofuran concentrations as a measure of lipid peroxidation (NCT01366976)
Timeframe: 24 hours
| Intervention | pg/mL (Mean) | |||||
|---|---|---|---|---|---|---|
| baseline | 30min of bypass | 60min of bypass | post-bypass | ICU | postoperative day 1 | |
| Acetaminophen | 61.5 | 72.1 | 83.4 | 82.9 | 85.3 | 70.4 |
| Placebo | 67.7 | 82.7 | 110.8 | 96.1 | 88.0 | 68.5 |
Serum creatinine measured over a 72 hour period (NCT01366976)
Timeframe: 72 hours
| Intervention | mg/dL (Mean) | |||
|---|---|---|---|---|
| baseline | postoperative day 1 | postoperative day 2 | postoperative day 3 | |
| Acetaminophen | 0.98 | 0.89 | 0.96 | 0.93 |
| Placebo | 0.94 | 0.90 | 0.96 | 0.88 |
Changes in urinary NGAL (neutrophil gelatinase-associated lipocalin) as marker of acute kidney injury (NCT01366976)
Timeframe: 24 hours
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| baseline | pos-bypass | postoperative day 1 | |
| Acetaminophen | 19.21 | 145.8 | 46.04 |
| Placebo | 23.2 | 138.4 | 16.8 |
6 reviews available for acetaminophen and Renal Insufficiency
| Article | Year |
|---|---|
Protective effect of probiotics against acetaminophen induced nephrotoxicity.
Topics: Acetaminophen; Glutathione; Humans; Probiotics; Renal Insufficiency; Uremia | 2022 |
Acute Liver Failure.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Critical Care; Drug Overdose; Hepatitis, Auto | 2018 |
A case of acetaminophen (paracetamol) causing renal failure without liver damage in a child and review of literature.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Female; Humans; Liver Function Tests; Renal Ins | 2010 |
Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure.
Topics: Acetaminophen; Animals; Disease Models, Animal; Humans; Hydrogen Peroxide; Iron; Kidney; Lipid Perox | 2011 |
[Paracetamol--the safe analgesic].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Female; Humans; Infant; I | 1997 |
Acute liver failure; clinical features and management.
Topics: Acetaminophen; Brain Edema; Diuretics, Osmotic; Hepatitis, Viral, Human; Humans; Liver Failure, Acut | 1999 |
15 other studies available for acetaminophen and Renal Insufficiency
| Article | Year |
|---|---|
[Acetaminophen (paracetamol) causing renal failure: report on 3 pediatric cases].
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Creatinine; Drug Overdose; Female; Follow-Up Studies | 2013 |
Hepato- and nephroprotective activities of a Nigerian local king tuber oyster mushroom, Pleurotus tuberregium (higher Basidiomycetes), in chemically induced organ toxicities in rats.
Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Carbon Tetrachloride; Complex Mixtures; Disease Model | 2014 |
Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studi | 2015 |
Neutrophil vacuolation in acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Female; Granulocyte Colony-Stimulating Factor; | 2015 |
Successful kidney transplants from a donor with acute hepatic failure due to acetaminophen overdose and acute kidney injury.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Death; Drug Overdose; Female; Graft Survival; | 2008 |
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure.
Topics: Acetaminophen; Animals; Arachidonic Acids; Catalysis; Dose-Response Relationship, Drug; Hemeproteins | 2010 |
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure.
Topics: Acetaminophen; Animals; Arachidonic Acids; Catalysis; Dose-Response Relationship, Drug; Hemeproteins | 2010 |
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure.
Topics: Acetaminophen; Animals; Arachidonic Acids; Catalysis; Dose-Response Relationship, Drug; Hemeproteins | 2010 |
Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure.
Topics: Acetaminophen; Animals; Arachidonic Acids; Catalysis; Dose-Response Relationship, Drug; Hemeproteins | 2010 |
Phytochemical screening, and assessment of ameliorating effect of aqueous and ethanolic extracts of Gmelina arborea on drug induced hepatic and renal insufficiency in rats.
Topics: Acetaminophen; Animals; Cisplatin; Hepatic Insufficiency; Phytotherapy; Plant Extracts; Rats; Rats, | 2012 |
Serum phosphate is not a reliable early predictor of outcome in paracetamol induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Liver Failure; Phosphates; Prognosis; Recovery of F | 2004 |
An unusual paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Critical Care; Drug Overdose; Humans; Hypernatremia; Male; | 2004 |
Experiences of a poison center network with renal insufficiency in acetaminophen overdose: an analysis of 17 cases.
Topics: Acetaminophen; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Analgesics, Non-Nar | 2005 |
[Case report of repeated acetaminophen overdosing with various symptoms].
Topics: Abdominal Pain; Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Disseminated Intravasc | 2006 |
Renal failure is uncommon in Chinese patients with paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; China; Female; Hong Kong; Humans; Inciden | 1995 |
Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency.
Topics: Acetaminophen; Aged; Alcoholism; Chronic Disease; Glutathione; Heart Failure; Humans; Kidney; Liver; | 1994 |
Analgesic use and renal function in men.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort St | 2001 |
Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Coma; Diagnosis, Diff | 2001 |