Page last updated: 2024-10-22

acetaminophen and Primary Peritonitis

acetaminophen has been researched along with Primary Peritonitis in 5 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, Y1
Seipel, C1
Lopez, ME1
Nuchtern, JG1
Brandt, ML1
Fallon, SC1
Manyang, PA1
Tjia, IM1
Baijal, RG1
Watcha, MF1
Si, Y1
Tsou, CL1
Croft, K1
Charo, IF1
Larsen, FS1
Clemmesen, JO1
Hansen, BA1
Doherty, NS1
Beaver, TH1
Chan, KY1
Dinerstein, RJ1
Diekema, KA1
Lesser, PB1
Vietti, MM1
Clark, WD1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparing Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy: A Randomized Controlled Trial[NCT03528343]Phase 1/Phase 20 participants (Actual)Interventional2017-09-05Withdrawn (stopped due to Lost research support for enrolling patients)
ROPIVACAINE WITH CLONIDINE FOR PEDIATRIC RECTUS SHEATH BLOCKS- THE MAGIC COMBINATION? - A Double Blinded Prospective Study[NCT02439281]50 participants (Actual)Interventional2015-05-31Terminated (stopped due to The patients were discharged on the day of the surgery.)
A Randomized, Double-blinded, Placebo-controlled Study of Ketorolac Use in Pediatric Patients Undergoing Tonsillectomy[NCT03453541]Phase 4600 participants (Anticipated)Interventional2017-11-21Recruiting
The Evaluation of Pre-incisional and Post-closure Local Anesthetic vs. Normal Saline on Postoperative Pain in Pediatric Appendectomies[NCT02483689]100 participants (Anticipated)Interventional2015-08-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Average Pain Severity at the Umbilicus Laparoscopic Site

Numeric Rating Pain Scores ( 0-10), will be obtained every 2 hours after PACU discharge up to 18 hours or until hospital discharge, whichever occurs first. The pain score of 0, means no pain, is a good outcome , and a pain score of 10 is excruciating pain, a very bad outcome. The average of these scores will be evaluated.The pain scores will not longer be documented after the numbness went away. (NCT02439281)
Timeframe: Logistic regression of the 4 th pain score assessment

Interventionunits on a scale (Median)
Ropivacaine Group2
Ropivacaine/ Clonidine Group1.5

Change in Anxiety Scores

The investigators hypothesize that patient postoperative anxiety scores are lower in the Ropivacaine/Clonidine group and postoperative anxiety scores decrease more in Ropivacaine /Clonidine Group, than in Ropivacaine Group. (NCT02439281)
Timeframe: 6 hours after block placement

Interventionunits on a scale (Median)
Ropivacaine Group30
Ropivacaine/ Clonidine Group29

Complications Rate

The investigators expect no difference in incidence of complications (e.g. oversedation, hypotension, bradycardia episodes, etc.). (NCT02439281)
Timeframe: until study completion

InterventionParticipants (Count of Participants)
Ropivacaine/ Clonidine Group1
Ropivacaine Group1

Duration of Analgesia at Umbilicus Instrument Site-How Many Minutes Passed From the Time When the Blocks Where Performed Until Patient Reported Pain at Umbilicus

The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in longer duration of analgesia and decreased pain scores compared to ropivacaine alone. (NCT02439281)
Timeframe: indicated by the first request for pain medication at umbilicus site

Interventionminutes (Median)
Ropivacaine/ Clonidine Group230
Ropivacaine Group240

Duration of Sensory Block (Paresthesia)

The investigators hypothesize that rectus sheath injections with ropivacaine and clonidine result in longer duration of sensory block (paresthesia) compared to ropivacaine alone. (NCT02439281)
Timeframe: Indicated by return of normal sensation (expected average of 12 hours after block placement).

Interventionminutes (Median)
Ropivacaine/ Clonidine Group823.5
Ropivacaine Group540

Medication Consumption

Total intravenous morphine equivalents mg/kg (NCT02439281)
Timeframe: 18 hours after surgery

Interventionmg/kg (Median)
Ropivacaine/ Clonidine Group0.20
Ropivacaine Group0.22

Satisfaction With Pain Control From Patient

The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in better satisfaction with pain control. (NCT02439281)
Timeframe: Prior to hospital discharge (up to 24 hours after surgery)

Interventionunits on a scale (Median)
Ropivacaine/ Clonidine Group9
Ropivacaine Group9

Other Studies

5 other studies available for acetaminophen and Primary Peritonitis

ArticleYear
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
A retrospective study of multimodal analgesic treatment after laparoscopic appendectomy in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:12

    Topics: Acetaminophen; Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opio

2013
CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.
    The Journal of clinical investigation, 2010, Volume: 120, Issue:4

    Topics: Acetaminophen; Animals; Cell Differentiation; Cell Lineage; Cell Movement; Cell Proliferation; Hemat

2010
[Hemorrhagic pancreatitis. A rare complication of paracetamol poisoning].
    Ugeskrift for laeger, 1995, Feb-13, Volume: 157, Issue:7

    Topics: Acetaminophen; Drug Overdose; Fatal Outcome; Female; Hemorrhage; Humans; Middle Aged; Pancreatitis;

1995
The antinociceptive activity of paracetamol in zymosan-induced peritonitis in mice: the role of prostacyclin and reactive oxygen species.
    British journal of pharmacology, 1990, Volume: 101, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Analgesics; Animals; Dinoprostone; Epoprostenol; Free R

1990
Lethal enhancement of therapeutic doses of acetaminophen by alcohol.
    Digestive diseases and sciences, 1986, Volume: 31, Issue:1

    Topics: Acetaminophen; Autopsy; Bacterial Infections; Chemical and Drug Induced Liver Injury; Drug Synergism

1986