acetaminophen has been researched along with Premature Birth in 16 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Premature Birth: CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy of occipital nerve block compared with standard care , defined as acetaminophen with caffeine, for treatment of acute headache in pregnancy." | 9.69 | Occipital Nerve Block Compared With Acetaminophen and Caffeine for Headache Treatment in Pregnancy: A Randomized Controlled Trial. ( Blanchard, CT; Bushman, ET; Casey, BM; Cozzi, GD; Davis, AM; Digre, KB; Harper, L; Jones, B; Robbins, LS; Sinkey, RG; Szychowski, JM; Tita, AT, 2023) |
| "Databases were searched to identify studies reporting the effects of acetaminophen use during pregnancy on preterm birth, low birth weight, and small for gestational age." | 9.22 | Effect of Acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis. ( Barreto, ML; Castro, CT; Dal-Pizzol, TS; Gama, RS; Oliveira, MG; Pereira, M; Santos, DB, 2022) |
| "Acetaminophen is commonly used during pregnancy." | 8.86 | A review of the literature on the effects of acetaminophen on pregnancy outcome. ( Ang, R; Breitmeyer, J; Royal, MA; Scialli, AR, 2010) |
| "Overall, 74% of women reported acetaminophen use during pregnancy." | 8.12 | Prenatal acetaminophen use in women with autoimmune disorders and adverse pregnancy and birth outcomes. ( Bandoli, G; Chambers, C; Killion, JA; Smith, CJF, 2022) |
| " Poisson regression with robust error variance was used to estimate the relationship between acetaminophen use before and during pregnancy and low birthweight, preterm birth, and small for gestational age." | 7.96 | Association between maternal acetaminophen use and adverse birth outcomes in a pregnancy and birth cohort. ( Arneja, J; Bocking, A; Brooks, JD; Hewko, SL; Hung, RJ; Knight, JA; Lye, SJ; Seeto, RA, 2020) |
| "Acetaminophen use during pregnancy has been associated with a reduced risk of stillbirth and preterm birth, but findings are based on few studies with small numbers of exposed women." | 7.75 | Use of acetaminophen during pregnancy and risk of adverse pregnancy outcomes. ( Bech, BH; Kogevinas, M; Olsen, J; Rebordosa, C; Sørensen, HT, 2009) |
| "To evaluate the efficacy of occipital nerve block compared with standard care , defined as acetaminophen with caffeine, for treatment of acute headache in pregnancy." | 5.69 | Occipital Nerve Block Compared With Acetaminophen and Caffeine for Headache Treatment in Pregnancy: A Randomized Controlled Trial. ( Blanchard, CT; Bushman, ET; Casey, BM; Cozzi, GD; Davis, AM; Digre, KB; Harper, L; Jones, B; Robbins, LS; Sinkey, RG; Szychowski, JM; Tita, AT, 2023) |
| "Databases were searched to identify studies reporting the effects of acetaminophen use during pregnancy on preterm birth, low birth weight, and small for gestational age." | 5.22 | Effect of Acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis. ( Barreto, ML; Castro, CT; Dal-Pizzol, TS; Gama, RS; Oliveira, MG; Pereira, M; Santos, DB, 2022) |
| "Acetaminophen is commonly used during pregnancy." | 4.86 | A review of the literature on the effects of acetaminophen on pregnancy outcome. ( Ang, R; Breitmeyer, J; Royal, MA; Scialli, AR, 2010) |
| "Overall, 74% of women reported acetaminophen use during pregnancy." | 4.12 | Prenatal acetaminophen use in women with autoimmune disorders and adverse pregnancy and birth outcomes. ( Bandoli, G; Chambers, C; Killion, JA; Smith, CJF, 2022) |
| " Poisson regression with robust error variance was used to estimate the relationship between acetaminophen use before and during pregnancy and low birthweight, preterm birth, and small for gestational age." | 3.96 | Association between maternal acetaminophen use and adverse birth outcomes in a pregnancy and birth cohort. ( Arneja, J; Bocking, A; Brooks, JD; Hewko, SL; Hung, RJ; Knight, JA; Lye, SJ; Seeto, RA, 2020) |
| "Acetaminophen use during pregnancy has been associated with a reduced risk of stillbirth and preterm birth, but findings are based on few studies with small numbers of exposed women." | 3.75 | Use of acetaminophen during pregnancy and risk of adverse pregnancy outcomes. ( Bech, BH; Kogevinas, M; Olsen, J; Rebordosa, C; Sørensen, HT, 2009) |
| "Paracetamol promotes early closure of patent ductus arteriosus (PDA), and it may affect inflammation after preterm birth." | 3.01 | Inflammatory biomarkers in very preterm infants during early intravenous paracetamol administration. ( Aikio, O; Hallman, M; Härkin, P; Härmä, A; Leskinen, M; Saarela, T; Salminen, A; Valkama, M, 2021) |
| "The rate of pregnant women with an opioid use disorder has risen drastically in the past 20 years, paralleling that in the general population." | 2.66 | Opioid Use and Misuse in Pregnancy. ( Landau, R; Shatil, B, 2020) |
| "NSAID use in pregnancy is associated with SGA but not preterm birth." | 1.91 | Associations of prenatal exposure to non-steroidal anti-inflammatory drugs with preterm birth and small for gestational age infants among women with autoimmune disorders. ( Bandoli, G; Chambers, C; Delker, E; Johnson, D; Kelly, A, 2023) |
| " We studied whether the use of paracetamol had an adverse influence on neonatal adaptation and the outcomes of infants during the first hospitalization." | 1.72 | Paracetamol preceding very preterm birth: Is it safe? ( Aikio, O; Hallman, M; Laitala, A; Saarela, T; Vääräsmäki, M, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 12 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aikio, O | 3 |
| Härmä, A | 2 |
| Härkin, P | 2 |
| Leskinen, M | 2 |
| Valkama, M | 2 |
| Saarela, T | 3 |
| Salminen, A | 1 |
| Hallman, M | 3 |
| Castro, CT | 1 |
| Gama, RS | 1 |
| Pereira, M | 2 |
| Oliveira, MG | 1 |
| Dal-Pizzol, TS | 1 |
| Barreto, ML | 1 |
| Santos, DB | 1 |
| Katler, QS | 1 |
| Kawwass, JF | 1 |
| Hurst, BS | 1 |
| Sparks, AE | 1 |
| McCulloh, DH | 1 |
| Wantman, E | 1 |
| Toner, JP | 1 |
| de Castro, CT | 1 |
| Dos Santos, DB | 1 |
| Zafeiri, A | 1 |
| Raja, EA | 1 |
| Mitchell, RT | 1 |
| Hay, DC | 1 |
| Bhattacharya, S | 1 |
| Fowler, PA | 1 |
| Laitala, A | 1 |
| Vääräsmäki, M | 1 |
| Delker, E | 1 |
| Kelly, A | 1 |
| Chambers, C | 2 |
| Johnson, D | 1 |
| Bandoli, G | 2 |
| Bushman, ET | 1 |
| Blanchard, CT | 1 |
| Cozzi, GD | 1 |
| Davis, AM | 1 |
| Harper, L | 1 |
| Robbins, LS | 1 |
| Jones, B | 1 |
| Szychowski, JM | 1 |
| Digre, KB | 1 |
| Casey, BM | 1 |
| Tita, AT | 1 |
| Sinkey, RG | 1 |
| Arneja, J | 1 |
| Hung, RJ | 1 |
| Seeto, RA | 1 |
| Knight, JA | 1 |
| Hewko, SL | 1 |
| Bocking, A | 1 |
| Lye, SJ | 1 |
| Brooks, JD | 1 |
| Shatil, B | 1 |
| Landau, R | 1 |
| Faim, DRO | 1 |
| Tiago, JAM | 1 |
| Castelo, RJS | 1 |
| Francisco, ASS | 1 |
| Alves, RR | 1 |
| Pires, AMGS | 1 |
| Killion, JA | 1 |
| Smith, CJF | 1 |
| Rebordosa, C | 1 |
| Kogevinas, M | 1 |
| Bech, BH | 1 |
| Sørensen, HT | 1 |
| Olsen, J | 1 |
| Scialli, AR | 1 |
| Ang, R | 1 |
| Breitmeyer, J | 1 |
| Royal, MA | 1 |
| Czeizel, AE | 1 |
| Dudás, I | 1 |
| Puhó, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Extremely Low Gestational Age Infants' Paracetamol Study: a Randomized Trial[NCT03641209] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2018-09-03 | Active, not recruiting | ||
| Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus of Preterm Infants - Randomised, Placebo-controlled Multicentre Trial[NCT03648437] | Phase 1 | 60 participants (Anticipated) | Interventional | 2018-09-03 | Recruiting | ||
| The Preterm Infants' Paracetamol Study[NCT01938261] | Phase 2 | 120 participants (Anticipated) | Interventional | 2013-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for acetaminophen and Premature Birth
| Article | Year |
|---|---|
Effect of Acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Birth Weight; Female; Fetal Development; Humans; Infant, Ne | 2022 |
Vanquishing multiple pregnancy in in vitro fertilization in the United States-a 25-year endeavor.
Topics: Acetaminophen; Aspirin; Female; Fertilization in Vitro; Humans; Infant, Low Birth Weight; Infant, Ne | 2022 |
Opioid Use and Misuse in Pregnancy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory A | 2020 |
A review of the literature on the effects of acetaminophen on pregnancy outcome.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Female; | 2010 |
3 trials available for acetaminophen and Premature Birth
| Article | Year |
|---|---|
Inflammatory biomarkers in very preterm infants during early intravenous paracetamol administration.
Topics: Acetaminophen; Administration, Intravenous; Biomarkers; Ductus Arteriosus, Patent; Humans; Infant, N | 2021 |
Occipital Nerve Block Compared With Acetaminophen and Caffeine for Headache Treatment in Pregnancy: A Randomized Controlled Trial.
Topics: Acetaminophen; Anesthetics, Local; Caffeine; Female; Headache; Humans; Infant, Newborn; Nerve Block; | 2023 |
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar | 2016 |
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar | 2016 |
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar | 2016 |
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar | 2016 |
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar | 2016 |
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar | 2016 |
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar | 2016 |
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar | 2016 |
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Double-Blind Method; Ductus Ar | 2016 |
9 other studies available for acetaminophen and Premature Birth
| Article | Year |
|---|---|
Association between paracetamol use during pregnancy and perinatal outcomes: Prospective NISAMI cohort.
Topics: Acetaminophen; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Infant, Small for Gestatio | 2022 |
Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: cohort study of 151 141 singleton pregnancies.
Topics: Acetaminophen; Analgesics; Birth Weight; Cohort Studies; Female; Humans; Hypospadias; Infant, Newbor | 2022 |
Paracetamol preceding very preterm birth: Is it safe?
Topics: Acetaminophen; Female; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseas | 2022 |
Associations of prenatal exposure to non-steroidal anti-inflammatory drugs with preterm birth and small for gestational age infants among women with autoimmune disorders.
Topics: Acetaminophen; Anti-Inflammatory Agents; Female; Gestational Age; Humans; Infant; Infant, Newborn; I | 2023 |
Association between maternal acetaminophen use and adverse birth outcomes in a pregnancy and birth cohort.
Topics: Acetaminophen; Adult; Birth Weight; Cohort Studies; Female; Humans; Maternal Exposure; Ontario; Pois | 2020 |
PATENT DUCTUS ARTERIOSUS CLOSURE: EXPERIENCE FROM A TERTIARY REFERRAL CENTER.
Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; Indomethacin; | 2020 |
Prenatal acetaminophen use in women with autoimmune disorders and adverse pregnancy and birth outcomes.
Topics: Acetaminophen; Autoimmune Diseases; Cohort Studies; Female; Humans; Infant, Newborn; Pain; Pre-Eclam | 2022 |
Use of acetaminophen during pregnancy and risk of adverse pregnancy outcomes.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cohort Studies; Denmark; Female; Humans; Infant; Inf | 2009 |
Short-term paracetamol therapy during pregnancy and a lower rate of preterm birth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anti-Infective Agents; Chronic | 2005 |