acetaminophen has been researched along with Poisoning in 365 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Poisoning: Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Vomiting, retching, or need for rescue antiemetic treatment at 2 h was reported in 39 of 108 patients assigned to the shorter modified protocol compared with 71 of 109 allocated to the standard acetylcysteine regimen (adjusted odds ratio 0·26, 97·5% CI 0·13-0·52; p<0·0001), and in 45 of 109 patients who received ondansetron compared with 65 of 108 allocated placebo (0·41, 0·20-0·80; p=0·003)." | 9.19 | Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. ( Bateman, DN; Butcher, I; Cooper, JG; Coyle, J; Dear, JW; Eddleston, M; Gray, A; Lewis, SC; Rodriguez, A; Sandilands, EA; Thanacoody, HK; Thomas, SH; Veiraiah, A; Vliegenthart, AD; Webb, DJ, 2014) |
| "The mechanism of action of N-acetylcysteine in early acetaminophen poisoning is well understood, but much remains to be learned of the mechanism of its possible benefit in acetaminophen poisoning presenting beyond 15 hours." | 8.80 | Mechanism of action and value of N-acetylcysteine in the treatment of early and late acetaminophen poisoning: a critical review. ( Jones, AL, 1998) |
| "The optimal route and duration of administration for N-acetyl-cysteine in the management of acetaminophen (paracetamol) poisoning are controversial." | 8.80 | Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? ( Buckley, NA; Dawson, AH; O'Connell, DL; Whyte, IM, 1999) |
| "There are currently three protocols used for the administration of N-acetylcysteine in the treatment of acute paracetamol poisoning." | 8.79 | [Clinical-toxicological case (1). Dosage of N-acetylcysteine in acute paracetamol poisoning]. ( Kind, B; Krähenbúhl, S; Meier-Abt, PJ; Wyss, PA, 1996) |
| "Patients with glucose-6-phosphate dehydrogenase deficiency who overdose with acetaminophen should be monitored for the possible development of subsequent drug-induced hemolysis." | 8.79 | Hemolysis after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency. ( Perry, HE; Shannon, MW; Woolf, AD; Wright, RO, 1996) |
| "Although acetaminophen is commonly used in pregnancy, it can deplete glutathione concentrations and cause accumulation of 5-oxoproline, with subsequent metabolic acidosis." | 8.02 | Malnourishment-Associated Acetaminophen Toxicity in Pregnancy. ( Dom, AM; Olson-Chen, C; Royzer, R, 2021) |
| "We examined trends in emergency department (ED) presentation rates for acetaminophenrelated poisonings across Canada." | 7.96 | Trends in emergency department visits for acetaminophen-related poisonings: 2011-2019. ( Bang, F; Kaur, J; McFaull, SR, 2020) |
| "The purpose of this nationwide cohort study was to investigate the incidence and risk of coronary artery disease (CAD) in patients with acetaminophen (APAP) poisoning." | 7.88 | Acetaminophen Poisoning May Increase Coronary Artery Disease Risk: A Nationwide Cohort Study. ( Chen, WK; Chou, CY; Chung, WS; Chung, YT; Lin, CL; Tsai, WC, 2018) |
| "The long-term mortality of acetaminophen (APAP) poisoning has not yet been well studied; hence, we conducted this study to gain understanding of this issue." | 7.88 | Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan. ( Ho, CH; Hsu, CC; Huang, CC; Huang, HS; Lin, HJ; Su, SB; Wang, JJ; Weng, SF, 2018) |
| "Intravenous acetylcysteine (Acetadote™ in the US) is the treatment of choice for acute acetaminophen poisoning in most of the world." | 7.77 | Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose. ( Mullins, ME; Vitkovitsky, IV, 2011) |
| "Paracetamol (acetaminophen) poisoning is the leading cause of acute liver failure in Great Britain and the United States." | 7.74 | Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning. ( Griffiths, C; Majeed, A; Morgan, OW, 2007) |
| "We sought to compare antiemetic use after acetaminophen poisoning in patients treated with oral or intravenous (IV) N-acetylcysteine (NAC)." | 7.74 | Antiemetic use in acetaminophen poisoning: how does the route of N-acetylcysteine administration affect utilization? ( Bird, SB; Donovan, JL; Miller, MA; Navarro, M, 2007) |
| "In acute poisoning caused by acetaminophen (N-acetyl-p-aminophenol, APAP), it is critical to predict the onset of delayed liver injury based on the prompt measurement of serum APAP level and to administer the antidote N-acetylcysteine (NAC) without delay as needed." | 7.74 | [Clinical usefulness of the acetaminophen detection kit in treating acute poisoning--data from a survey of 28 cases treated at Niigata City general hospital]. ( Fujisawa, M; Hirose, Y; Hori, Y; Katsuyama, S; Oda, A; Takayama, M; Wakabayashi, H; Yamazaki, K, 2008) |
| "To identify risk factors in the development of side-effects to N-acetylcysteine (NAC) in patients with paracetamol poisoning." | 7.71 | Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning. ( Dalhoff, K; Schmidt, LE, 2001) |
| "Screening for acetaminophen toxicity is recommended in almost all cases of self poisoning." | 7.70 | Predictive properties of a qualitative urine acetaminophen screen in patients with self-poisoning. ( De Roos, F; Hollander, JE; Perrone, J; Shaw, L, 1999) |
| "It is often taught that acetaminophen-induced liver dysfunction occurs only after a latent period of 24 to 48 hours." | 7.69 | The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. ( Carracio, TR; Mofenson, HC; Singer, AJ, 1995) |
| "The prince of Wales Hospital is in a unique position for the study of the actual incidence of acetaminophen poisoning in Hong Kong because it is the sole general teaching hospital in the New Territories East and the age and sex distribution of the population in the region are readily available." | 7.69 | The epidemiology of acetaminophen (paracetamol) poisoning in Hong Kong. ( Chan, TY, 1996) |
| " When emesis occurred within one-half hour after ingestion, mean serum acetaminophen concentration drawn four hours after ingestion was approximately half that in a control group that received no decontamination." | 7.68 | Influence of time until emesis on the efficacy of decontamination using acetaminophen as a marker in a pediatric population. ( Bond, GR; Krenzelok, EP; McCarthy, T; McCoy, DJ; Morris, CL; Normann, SA; Requa, RK; Roblez, J; Tendler, JD; Thompson, MW, 1993) |
| "We report two cases of severe acetaminophen poisoning with favorable outcome after delayed medical treatment with N-acetylcysteine, despite severe hepatic disturbances." | 7.68 | Severe acetaminophen poisoning with favorable outcome after medical treatment: report of 2 cases. ( Deckers, O; Hantson, P; Mahieu, P; Van Vyve, T, 1993) |
| "We present a 17-year-old girl who developed persistent vomiting following acetaminophen overdose." | 7.68 | Ondansetron to prevent emesis following N-acetylcysteine for acetaminophen intoxication. ( Deshpande, JK; Gregory, DF; Tobias, JD, 1992) |
| "60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 7.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
| "To investigate the ability of a supranormal dose of N-acetylcysteine to overcome the effects of activated charcoal on N-acetylcysteine bioavailability and to determine the effects of activated charcoal on serum acetaminophen levels." | 6.67 | Use of activated charcoal in a simulated poisoning with acetaminophen: a new loading dose for N-acetylcysteine? ( Chamberlain, JM; Gorman, RL; Klein, BL; Klein-Schwartz, W; Oderda, GM, 1993) |
| " The average lengths of treatment and stay for IV dosing were 23." | 6.47 | Assessment of the clinical use of intravenous and oral N-acetylcysteine in the treatment of acute acetaminophen poisoning in children: a retrospective review. ( Blackford, MG; Felter, T; Gothard, MD; Reed, MD, 2011) |
| "Acetaminophen is a widely available analgesic and antipyretic medication." | 5.51 | [Acetaminophen poisonings hospitalized at the Pomeranian Center of Toxicology in 2010-2015]. ( Garczewski, B; Sein Anand, J; Waldman, W; Wiśniewski, M, 2019) |
| " This study evaluated the effect of a weight-based dosing chart (WBDC) introduced to decrease NAC prescription errors." | 5.39 | Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning. ( Greene, S; McD Taylor, D; McIntyre, S, 2013) |
| " dosing can cause symptomatic hyponatraemia in children." | 5.37 | Using 0.45% saline solution and a modified dosing regimen for infusing N-acetylcysteine in children with paracetamol poisoning. ( Deasy, C; Oakley, E; Robinson, J, 2011) |
| "Acetaminophen is an analgesic drug that is frequently used in suicide attempts." | 5.35 | Severe acetaminophen poisoning treated with a fractionated plasma separation and absorption system: A case report. ( Güvenç, B; Murt, M; Rana Alpay, N; Satar, S; Sebe, A, 2009) |
| "Diethylene glycol (DEG) was found in patients' bottles in a median concentration of 14." | 5.30 | Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Acute Renal Failure Investigation Team. ( Barr, DB; Barr, JR; Denerville, K; Espindola, J; Hecdivert, C; Hospedales, CJ; Lewis, MJ; Louis, M; Needham, LL; O'Brien, KL; Philen, RM; Placide, MF; Schwartz, B; Selanikio, JD; St Victor, S, 1998) |
| "Metoclopramide has been shown to cause sulfhemoglobinemia, particularly when used in repeated high doses." | 5.30 | An adolescent case of sulfhemoglobinemia associated with high-dose metoclopramide and N-acetylcysteine. ( Langford, JS; Sheikh, S, 1999) |
| " Follow-up by the certified Regional Poison Information Center at 1-3 w post-discharge determined dosing compliance to be 83%." | 5.29 | Outpatient N-acetylcysteine treatment for acetaminophen poisoning: an ethical dilemma or a new financial mandate? ( Bricker, JD; Dean, BS; Krenzelok, EP, 1996) |
| " Vomiting, retching, or need for rescue antiemetic treatment at 2 h was reported in 39 of 108 patients assigned to the shorter modified protocol compared with 71 of 109 allocated to the standard acetylcysteine regimen (adjusted odds ratio 0·26, 97·5% CI 0·13-0·52; p<0·0001), and in 45 of 109 patients who received ondansetron compared with 65 of 108 allocated placebo (0·41, 0·20-0·80; p=0·003)." | 5.19 | Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. ( Bateman, DN; Butcher, I; Cooper, JG; Coyle, J; Dear, JW; Eddleston, M; Gray, A; Lewis, SC; Rodriguez, A; Sandilands, EA; Thanacoody, HK; Thomas, SH; Veiraiah, A; Vliegenthart, AD; Webb, DJ, 2014) |
| "The acquired form of 5-oxoproline (pyroglutamic acid) metabolic acidosis was first described in 1989 and its relationship to chronic acetaminophen ingestion was proposed the next year." | 4.90 | Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle. ( Emmett, M, 2014) |
| "Paracetamol (acetaminophen) is the most common drug taken in overdose in the UK, accounting for 48% of poisoning admissions to hospital and being involved in an estimated 100-200 deaths per year." | 4.84 | Impact of restricting paracetamol pack sizes on paracetamol poisoning in the United Kingdom: a review of the literature. ( Dargan, PI; Edwards, JN; Hawkins, LC, 2007) |
| " More common and serious poisonings caused by paracetamol, salicylates, opioids, tricyclic antidepressants, selective serotonin reuptake inhibitors, benzodiazepines, non-steroidal anti-inflammatory drugs, and cocaine are discussed in detail." | 4.82 | Acute poisoning: understanding 90% of cases in a nutshell. ( Dargan, PI; Greene, SL; Jones, AL, 2005) |
| "Whether accidental or intentional, acetaminophen poisoning is not uncommon; in fact, it is the most common drug-induced cause of liver failure." | 4.80 | When acetaminophen use becomes toxic. Treating acute accidental and intentional overdose. ( Kosnik, SD; Salgia, AD, 1999) |
| "The optimal route and duration of administration for N-acetyl-cysteine in the management of acetaminophen (paracetamol) poisoning are controversial." | 4.80 | Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? ( Buckley, NA; Dawson, AH; O'Connell, DL; Whyte, IM, 1999) |
| "Acetaminophen poisoning is a significant medical problem in the United States and is frequently managed by family physicians." | 4.79 | Management of acetaminophen toxicity. ( Fuller, SH; Larsen, LC, 1996) |
| "There are currently three protocols used for the administration of N-acetylcysteine in the treatment of acute paracetamol poisoning." | 4.79 | [Clinical-toxicological case (1). Dosage of N-acetylcysteine in acute paracetamol poisoning]. ( Kind, B; Krähenbúhl, S; Meier-Abt, PJ; Wyss, PA, 1996) |
| "Patients with glucose-6-phosphate dehydrogenase deficiency who overdose with acetaminophen should be monitored for the possible development of subsequent drug-induced hemolysis." | 4.79 | Hemolysis after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency. ( Perry, HE; Shannon, MW; Woolf, AD; Wright, RO, 1996) |
| "Based on recent reports concerning the efficacy of N-acetylcysteine (NAC) in paracetamol (acetaminophen) poisoning, guidelines for treatment and control of these patients are reviewed by a study group under the Danish Association for the Study of the Liver." | 4.79 | [Recommendations for treatment of paracetamol poisoning. Danish Medical Society, Study of the Liver]. ( Astrup, LB; Clemmesen, JO; Dalhoff, KP; Ott, P; Poulsen, HE; Tage-Jensen, U, 1996) |
| "Although acetaminophen is commonly used in pregnancy, it can deplete glutathione concentrations and cause accumulation of 5-oxoproline, with subsequent metabolic acidosis." | 4.02 | Malnourishment-Associated Acetaminophen Toxicity in Pregnancy. ( Dom, AM; Olson-Chen, C; Royzer, R, 2021) |
| " Paracetamol, amitriptyline, chlorpromazine, ferrous sulphate, kerosene, organophosphates, carbon monoxide, snake bite, alcohol and rodenticides were involved in the poisoning." | 3.91 | Childhood Drug and Non-Drug Poisoning in Nigeria: An Economic Appraisal. ( Chijioke-Nwauche, I; Ikhile, I; Orisakwe, OE, 2019) |
| "The purpose of this nationwide cohort study was to investigate the incidence and risk of coronary artery disease (CAD) in patients with acetaminophen (APAP) poisoning." | 3.88 | Acetaminophen Poisoning May Increase Coronary Artery Disease Risk: A Nationwide Cohort Study. ( Chen, WK; Chou, CY; Chung, WS; Chung, YT; Lin, CL; Tsai, WC, 2018) |
| "Intravenous acetylcysteine (Acetadote™ in the US) is the treatment of choice for acute acetaminophen poisoning in most of the world." | 3.77 | Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose. ( Mullins, ME; Vitkovitsky, IV, 2011) |
| " There were more dialysis treatments for poisonings with valproate and acetaminophen in 2001-2005 than for methanol and theophylline, although hemodialysis for acetaminophen removal is generally not recommended." | 3.74 | Use of hemodialysis and hemoperfusion in poisoned patients. ( Goldfarb, DS; Hoffman, RS; Holubek, WJ; Nelson, LS, 2008) |
| "Paracetamol (acetaminophen) poisoning is the leading cause of acute liver failure in Great Britain and the United States." | 3.74 | Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning. ( Griffiths, C; Majeed, A; Morgan, OW, 2007) |
| " Recommendations for gut decontamination for acetaminophen poisoning were: activated charcoal (AC) alone (5 centres); gastric lavage (GL) alone (1); AC and/or GL (3); AC, GL and/or ipecac (2)." | 3.74 | Differences in treatment advice for common poisons by poisons centres--an international comparison. ( Bateman, DN; Good, AM; Kelly, CA, 2007) |
| "We sought to compare antiemetic use after acetaminophen poisoning in patients treated with oral or intravenous (IV) N-acetylcysteine (NAC)." | 3.74 | Antiemetic use in acetaminophen poisoning: how does the route of N-acetylcysteine administration affect utilization? ( Bird, SB; Donovan, JL; Miller, MA; Navarro, M, 2007) |
| "In acute poisoning caused by acetaminophen (N-acetyl-p-aminophenol, APAP), it is critical to predict the onset of delayed liver injury based on the prompt measurement of serum APAP level and to administer the antidote N-acetylcysteine (NAC) without delay as needed." | 3.74 | [Clinical usefulness of the acetaminophen detection kit in treating acute poisoning--data from a survey of 28 cases treated at Niigata City general hospital]. ( Fujisawa, M; Hirose, Y; Hori, Y; Katsuyama, S; Oda, A; Takayama, M; Wakabayashi, H; Yamazaki, K, 2008) |
| "About 500 drug poisoning deaths involving paracetamol (acetaminophen) occur every year in England and Wales." | 3.73 | Impact of paracetamol pack size restrictions on poisoning from paracetamol in England and Wales: an observational study. ( Griffiths, C; Majeed, A; Morgan, O, 2005) |
| "The purpose of this study was to determine whether patient outcomes were adversely affected as healthcare referral values increased for two common poisonings: acute, unintentional acetaminophen (APAP) poisonings and acute, unintentional iron (Fe) poisonings." | 3.72 | Do poison center guidelines adversely affect patient outcomes as triage referral values increase? ( Benson, BE; Cheshire, S; Foster, H; Litovitz, TL; McKinney, PE; Tandberg, D, 2003) |
| "To identify risk factors in the development of side-effects to N-acetylcysteine (NAC) in patients with paracetamol poisoning." | 3.71 | Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning. ( Dalhoff, K; Schmidt, LE, 2001) |
| "The purpose of this study was to determine the extent to which poison center triage guidelines influence healthcare facility referral rates for acute, unintentional acetaminophen-only poisoning and acute, unintentional adult formulation iron poisoning." | 3.71 | Do poison center triage guidelines affect healthcare facility referrals? ( Benson, BE; Litovitz, TL; McKinney, PE; Smith, CA; Tandberg, WD, 2001) |
| "A short cut review was carried out to establish whether vomiting was a significant consequence of paracetamol (acetaminophen) overdose." | 3.71 | Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Vomiting in paracetamol overdose. ( Clarke, S; Herren, K, 2002) |
| "Acetaminophen is frequently used in self-poisoning in Western countries." | 3.71 | Treatment strategies for early presenting acetaminophen overdose: a survey of medical directors of poison centers in North America and Europe. ( Kozer, E; McGuigan, M, 2002) |
| "Screening for acetaminophen toxicity is recommended in almost all cases of self poisoning." | 3.70 | Predictive properties of a qualitative urine acetaminophen screen in patients with self-poisoning. ( De Roos, F; Hollander, JE; Perrone, J; Shaw, L, 1999) |
| "In this retrospective study we evaluated the frequency of complications in 108 patients with acetaminophen poisoning admitted to the Department of Hepatology, Rigshospitalet, Copenhagen from 1." | 3.69 | [Paracetamol poisoning at a department of hepatology]. ( Clemmesen, JO; Hansen, BA; Larsen, FS; Ott, P, 1995) |
| "It is often taught that acetaminophen-induced liver dysfunction occurs only after a latent period of 24 to 48 hours." | 3.69 | The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. ( Carracio, TR; Mofenson, HC; Singer, AJ, 1995) |
| "Acetaminophen is widely used in human beings for analgesic purposes, but is one of the most frequent causes of poisoning in cats." | 3.69 | Comparison of N-acetylcysteine and methylene blue, alone or in combination, for treatment of acetaminophen toxicosis in cats. ( Lin, YS; Oehme, FW; Rumbeiha, WK, 1995) |
| "The prince of Wales Hospital is in a unique position for the study of the actual incidence of acetaminophen poisoning in Hong Kong because it is the sole general teaching hospital in the New Territories East and the age and sex distribution of the population in the region are readily available." | 3.69 | The epidemiology of acetaminophen (paracetamol) poisoning in Hong Kong. ( Chan, TY, 1996) |
| "To determine whether the antidote for acetaminophen poisoning, N-acetylcysteine, administered to pregnant women with acetaminophen toxicity, crosses the placenta and can be measured in the newborn circulation following delivery." | 3.69 | Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity. ( Bearer, CF; Dart, RC; Gupta, U; Horowitz, RS; Jarvie, DR, 1997) |
| " When emesis occurred within one-half hour after ingestion, mean serum acetaminophen concentration drawn four hours after ingestion was approximately half that in a control group that received no decontamination." | 3.68 | Influence of time until emesis on the efficacy of decontamination using acetaminophen as a marker in a pediatric population. ( Bond, GR; Krenzelok, EP; McCarthy, T; McCoy, DJ; Morris, CL; Normann, SA; Requa, RK; Roblez, J; Tendler, JD; Thompson, MW, 1993) |
| "We report two cases of severe acetaminophen poisoning with favorable outcome after delayed medical treatment with N-acetylcysteine, despite severe hepatic disturbances." | 3.68 | Severe acetaminophen poisoning with favorable outcome after medical treatment: report of 2 cases. ( Deckers, O; Hantson, P; Mahieu, P; Van Vyve, T, 1993) |
| "We present a 17-year-old girl who developed persistent vomiting following acetaminophen overdose." | 3.68 | Ondansetron to prevent emesis following N-acetylcysteine for acetaminophen intoxication. ( Deshpande, JK; Gregory, DF; Tobias, JD, 1992) |
| " These episodes were characterized by apnea plus some combination of color change, choking or gagging, and abnormal muscle tone." | 3.67 | Parental administration of chemical agents: a cause of apparent life-threatening events. ( Altemeier, WA; Campbell, PW; Hickson, GB; Martin, ED, 1989) |
| "60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 3.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
| " Adding charcoal to the model overcame the suggested beneficial effect of CCK alone in the dosing arm." | 2.71 | The use of cholecystokinin as an adjunctive treatment for toxin ingestion. ( Hofbauer, RD; Holger, JS, 2004) |
| " The mean reduction in acetaminophen bioavailability because of gastric lavage was 20%+/-28% (95% confidence interval 3 to 37)." | 2.69 | Gastric lavage for liquid poisons. ( Green, R; Grierson, R; Sitar, DS; Tenenbein, M, 2000) |
| " This corresponds to decreases in bioavailability of 67, 11, and 21%." | 2.68 | Efficacy of ipecac during the first hour after drug ingestion in human volunteers. ( Saincher, A; Sitar, DS; Tenenbein, M, 1997) |
| "To investigate the ability of a supranormal dose of N-acetylcysteine to overcome the effects of activated charcoal on N-acetylcysteine bioavailability and to determine the effects of activated charcoal on serum acetaminophen levels." | 2.67 | Use of activated charcoal in a simulated poisoning with acetaminophen: a new loading dose for N-acetylcysteine? ( Chamberlain, JM; Gorman, RL; Klein, BL; Klein-Schwartz, W; Oderda, GM, 1993) |
| "Oral poisoning is a major cause of mortality and disability worldwide, with estimates of over 100,000 deaths due to unintentional poisoning each year and an overrepresentation of children below five years of age." | 2.58 | First aid interventions by laypeople for acute oral poisoning. ( Avau, B; Borra, V; De Buck, E; De Paepe, P; Vandekerckhove, P; Vanhove, AC, 2018) |
| " Some authors do not recommend treatment with N-acetylcysteine at low paracetamol plasma concentrations since unnecessary adverse effects may be induced." | 2.50 | Recommendations for the paracetamol treatment nomogram and side effects of N-acetylcysteine. ( de Vries, I; Koppen, A; Meulenbelt, J; van Riel, A, 2014) |
| " The average lengths of treatment and stay for IV dosing were 23." | 2.47 | Assessment of the clinical use of intravenous and oral N-acetylcysteine in the treatment of acute acetaminophen poisoning in children: a retrospective review. ( Blackford, MG; Felter, T; Gothard, MD; Reed, MD, 2011) |
| "The severity of poisoning is assessed by gathering all information about the patient, the drug(s) ingested, the circumstances of ingestion, and any other substances ingested at the same time." | 2.46 | Acute poisoning following ingestion of medicines: initial management. How to treat life-threatening complications and to evaluate the risk of delayed effects and psychological distress. ( , 2010) |
| "A cardinal rule in the treatment of poisoning cases is to remove any unabsorbed material, limit the absorption of additional poison, and hasten its elimination." | 2.44 | [Analytic role in clinical toxicology--impact on the diagnosis and treatment of a poisoned patient]. ( Fukumoto, M, 2008) |
| "Paracetamol poisoning is implicated in about 150-200 poisoning deaths per year in England and Wales." | 2.43 | Restricting paracetamol in the United Kingdom to reduce poisoning: a systematic review. ( Majeed, A; Morgan, O, 2005) |
| "APAP is likely to remain a common toxic exposure and continue to cause significant morbidity and mortality." | 2.43 | Updates on acetaminophen toxicity. ( Eldridge, DL; Kirk, MA; Norvell, J; Rowden, AK, 2005) |
| " Although initial response to all pediatric poisonings begins with basic stabilization, knowledge of specific antidotes, their mechanisms of action, safety profile in pediatrics, and dosing regimens can be life-saving for pediatric victims of nerve gas exposure, acetaminophen toxicity, methanol and ethylene glycol ingestion, and snakebites." | 2.43 | Update on antidotes for pediatric poisoning. ( Liebelt, EL; White, ML, 2006) |
| " Better dosage forms are also required for rectal administration." | 2.42 | [New perspectives on paracetamol]. ( Prescott, LF, 2003) |
| "APAP poisoning is common, and despite the availability of a specific antidote, fatalities still occur." | 2.39 | Acetaminophen. Concepts and controversies. ( Anker, AL; Smilkstein, MJ, 1994) |
| "Most poisonings were intentional and occurred among younger women." | 1.91 | Repeated poisonings in Denmark - a nationwide study. ( Dalhoff, K; Jensen, TL; Studsgaard Petersen, T; Tejlbo Frost, M, 2023) |
| "Acetaminophen is a widely available analgesic and antipyretic medication." | 1.51 | [Acetaminophen poisonings hospitalized at the Pomeranian Center of Toxicology in 2010-2015]. ( Garczewski, B; Sein Anand, J; Waldman, W; Wiśniewski, M, 2019) |
| " A priority list of toxic agents for which improved analytical techniques could offer a more widespread availability and rapid access to clinically important test results is presented." | 1.46 | [Access to rapid laboratory analytical services in cases of acute poisoning provides better and safer patient care]. ( Beck, O; Elmgren, A; Hansson, T; Helander, A; Olsson, E, 2017) |
| "This article provides an overview on the Institute for Safe Medication Practices (ISMP), the only independent nonprofit organization in the USA devoted to the prevention of medication errors." | 1.42 | The Institute for Safe Medication Practices and Poison Control Centers: Collaborating to Prevent Medication Errors and Unintentional Poisonings. ( Vaida, AJ, 2015) |
| " This study evaluated the effect of a weight-based dosing chart (WBDC) introduced to decrease NAC prescription errors." | 1.39 | Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning. ( Greene, S; McD Taylor, D; McIntyre, S, 2013) |
| "Poisonings were classified according to the International Classification of Diseases, 10th revision, diagnostic codes ranging from T36-T65." | 1.38 | Unintentional paediatric poisoning in rural Victoria: incidence and admission rates. ( Cheng, DR; Ip, CC, 2012) |
| " dosing can cause symptomatic hyponatraemia in children." | 1.37 | Using 0.45% saline solution and a modified dosing regimen for infusing N-acetylcysteine in children with paracetamol poisoning. ( Deasy, C; Oakley, E; Robinson, J, 2011) |
| "Acetaminophen is an OTC medication and amongst the most used pain relievers." | 1.35 | [Accidental acetaminophen overdose]. ( Hamwi, I; Picksak, G; Stichtenoth, DO, 2008) |
| "Paracetamol poisoning is a major health problem worldwide." | 1.35 | Limiting paracetamol pack size: has it worked in the UK? ( Bateman, DN, 2009) |
| "Acetaminophen is an analgesic drug that is frequently used in suicide attempts." | 1.35 | Severe acetaminophen poisoning treated with a fractionated plasma separation and absorption system: A case report. ( Güvenç, B; Murt, M; Rana Alpay, N; Satar, S; Sebe, A, 2009) |
| "55% of poisonings were intentional, where paracetamol and benzodiazepines were the preferred agents." | 1.34 | [A study of 355 consecutive acute poisoning cases admitted to an emergency ward at Copenhagen University Hospital, Bispebjerg in 2001]. ( Angelo, HR; Christensen, HR; Gude, AB; Hoegberg, LC; Nielsen, J; Pedersen, M, 2007) |
| "Acute poisoning is a significant health problem all over the world." | 1.33 | MS 04-044: demographic features of drug and chemical poisoning in northern Malaysia. ( Ab Rahman, AF; Fathelrahman, AI; Mohd Zain, Z, 2005) |
| "Data on fatal self-poisonings are recorded nationally within the UK and are codified according to the International Classification of Diseases (ICD) revision relevant at the time." | 1.32 | The epidemiology of self-poisoning in the UK. ( Bateman, DN; Camidge, DR; Wood, RJ, 2003) |
| " We concluded that management of acetaminophen toxicity can be optimized by early identification, obtaining a complete drug screen, starting N-acetylcysteine early or whenever toxic acetaminophen levels or elevated transaminases are identified, and referring patients with acetaminophen toxicity to a liver center." | 1.31 | Acetaminophen hepatoxicity. ( Broughan, TA; Soloway, RD, 2000) |
| " We have examined prospectively in routine clinical practice the concentrations of intravenous infusions of a drug (acetylcysteine) which is given according to a complicated dosing schedule." | 1.31 | Random and systematic medication errors in routine clinical practice: a multicentre study of infusions, using acetylcysteine as an example. ( Anton, C; Bateman, DN; Ferner, RE; Hutchings, A; Langford, NJ; Routledge, PA, 2001) |
| "Poisonings were considered serious in 9." | 1.31 | [Antipyretic poisoning]. ( Conejo Menor, JL; Lallana Duplá, MT, 2002) |
| "6." | 1.30 | Paracetamol poisoning in the north east of England: presentation, early management and outcome. ( Bateman, DN; Bevan, L; Bhattacharyya, S; Bramble, MG; Chew, K; Connolly, J; Dorani, B; Han, KH; Horner, JE; Rodgers, A; Sen, B; Tesfayohannes, B; Thomas, SH; Wynne, H, 1997) |
| "A higher frequency of chronic alcohol abuse among the patients with accidental overdoses may be one explanation." | 1.30 | Acetaminophen toxicity in an urban county hospital. ( Casey, DL; Lee, WM; Rochling, FA; Schiødt, FV, 1997) |
| "Adjustment disorder was the most common diagnosis followed by depression." | 1.30 | Overdose among youth in Bahrain: psycho-social characteristics, contact with helping agencies and problems. ( al-Ansari, AM; Buzaboon, B; Hamadeh, RR; Marhoon, H; Matar, AM; Raees, AG, 1997) |
| "Diethylene glycol (DEG) was found in patients' bottles in a median concentration of 14." | 1.30 | Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Acute Renal Failure Investigation Team. ( Barr, DB; Barr, JR; Denerville, K; Espindola, J; Hecdivert, C; Hospedales, CJ; Lewis, MJ; Louis, M; Needham, LL; O'Brien, KL; Philen, RM; Placide, MF; Schwartz, B; Selanikio, JD; St Victor, S, 1998) |
| "Metoclopramide has been shown to cause sulfhemoglobinemia, particularly when used in repeated high doses." | 1.30 | An adolescent case of sulfhemoglobinemia associated with high-dose metoclopramide and N-acetylcysteine. ( Langford, JS; Sheikh, S, 1999) |
| "To evaluate an animal model of multiple-dose activated charcoal (MDAC) therapy and correlate the pharmacokinetic properties of four drugs with the efficacy of MDAC." | 1.29 | Correlation of drug pharmacokinetics and effectiveness of multiple-dose activated charcoal therapy. ( Chyka, PA; Holley, JE; Mandrell, TD; Sugathan, P, 1995) |
| "Eight patients developed hepatic encephalopathy (HE) and two died." | 1.29 | Serial measurements of serum Gc-globulin in acetaminophen intoxication. ( Bondesen, S; Schiødt, FV; Tygstrup, N, 1995) |
| "Eight patients developed hepatic encephalopathy (HE) and two of them died." | 1.29 | [Gc-globulin in paracetamol poisoning]. ( Bondesen, S; Schiødt, FV; Tygstrup, N, 1996) |
| " Treatment of DAS (50 mg/kg) 3 hr after APAP dosing significantly (P < 0." | 1.29 | Protective effects of diallyl sulfide on acetaminophen-induced toxicities. ( Hu, JJ; Lin, M; Wang, EJ; Yang, CS; Yoo, JS, 1996) |
| " The clinico-pathophysiology and toxicology of paracetamol poisoning is briefly reviewed in an attempt to establish how low a fatal paracetamol dosage can go." | 1.28 | The fatal paracetamol dosage--how low can you go? ( Patel, F, 1992) |
| "This augmented necrosis is averted by prolonged treatment with hyperbaric oxygen." | 1.27 | Effect of hyperoxia on liver necrosis induced by hepatotoxins. ( Marzella, L; Muhvich, K; Myers, RA, 1986) |
| "Only hypotension has become less frequent as antidepressants replace barbiturates as the main cause of drug-induced coma." | 1.26 | Changing pattern of drugs used for self-poisoning. ( Park, J; Proudfoot, AT, 1978) |
| " It is concluded that haemoperfusion through this column is a safe and simple procedure, which merits evaluation in the treatment of severe drug overdose in man." | 1.26 | The safety assessment in the dog of a charcoal haemoperfusion column. ( Fennimore, J; Kolthammer, JC; Lang, S; Watson, PA, 1976) |
| " The effect of administering activated charcoal at varying intervals after dosing on the blood drug-level profiles of paracetamol and amylobarbitone was assessed by comparison with the profiles obtained when charcoal therapy was withheld." | 1.25 | Studies with activated charcoal in the treatment of drug overdosage using the pig as an animal model. ( Lipscomb, DJ; Widdop, B, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 90 (24.66) | 18.7374 |
| 1990's | 97 (26.58) | 18.2507 |
| 2000's | 104 (28.49) | 29.6817 |
| 2010's | 62 (16.99) | 24.3611 |
| 2020's | 12 (3.29) | 2.80 |
| Authors | Studies |
|---|---|
| Raina, A | 1 |
| Carne, B | 1 |
| Bothara, R | 1 |
| McCombie, A | 1 |
| Gee, P | 3 |
| Joyce, L | 1 |
| Ross, JA | 1 |
| Woodfin, MH | 1 |
| Rege, SV | 1 |
| Holstege, CP | 2 |
| Mehrpour, O | 2 |
| Hoyte, C | 1 |
| Delva-Clark, H | 1 |
| Al Masud, A | 1 |
| Biswas, A | 1 |
| Schimmel, J | 1 |
| Nakhaee, S | 1 |
| Goss, F | 1 |
| Kumpula, EK | 1 |
| Paterson, DA | 1 |
| Pomerleau, AC | 1 |
| Cairns, R | 2 |
| Noghrehchi, F | 1 |
| Buckley, NA | 5 |
| Jensen, TL | 1 |
| Tejlbo Frost, M | 1 |
| Dalhoff, K | 4 |
| Studsgaard Petersen, T | 1 |
| Garczewski, B | 1 |
| Wiśniewski, M | 1 |
| Waldman, W | 1 |
| Sein Anand, J | 1 |
| Nordmark Grass, J | 2 |
| Lindeman, E | 1 |
| Höjer, J | 1 |
| Personne, M | 1 |
| Hüser, C | 1 |
| Hackl, G | 1 |
| Baumgärtel, M | 1 |
| Bouvet, R | 1 |
| Cauchois, A | 1 |
| Baert, A | 1 |
| Fromenty, B | 1 |
| Morel, I | 1 |
| Turlin, B | 1 |
| Gicquel, T | 1 |
| Kaur, J | 1 |
| McFaull, SR | 1 |
| Bang, F | 1 |
| Dom, AM | 1 |
| Royzer, R | 1 |
| Olson-Chen, C | 1 |
| Vogelbacher, LC | 1 |
| Thimme, R | 1 |
| Olsson, E | 1 |
| Beck, O | 1 |
| Elmgren, A | 2 |
| Hansson, T | 1 |
| Helander, A | 2 |
| Chung, YT | 1 |
| Chou, CY | 1 |
| Tsai, WC | 1 |
| Chen, WK | 1 |
| Lin, CL | 1 |
| Chung, WS | 1 |
| Huang, HS | 1 |
| Ho, CH | 1 |
| Weng, SF | 1 |
| Hsu, CC | 1 |
| Wang, JJ | 2 |
| Su, SB | 1 |
| Lin, HJ | 1 |
| Huang, CC | 1 |
| Muñoz Romo, R | 1 |
| M Borobia Pérez, A | 1 |
| A Muñoz, M | 1 |
| Carballo Cardona, C | 1 |
| Cobo Mora, J | 1 |
| Carcas Sansuán, AJ | 1 |
| Vogel, T | 1 |
| Lüde, S | 1 |
| Baumgartner, R | 1 |
| Rauber-Lüthy, C | 1 |
| Simões-Wüst, AP | 1 |
| Koh, SH | 1 |
| Tan, KHB | 1 |
| Ganapathy, S | 1 |
| Nadler, A | 1 |
| Fein, DM | 1 |
| Pavlek, L | 1 |
| Kraft, M | 1 |
| Simmons, C | 1 |
| Ryan, M | 1 |
| Prusakov, P | 1 |
| Campbell, A | 1 |
| Brandehoff, N | 1 |
| Ng, PC | 1 |
| Russell, J | 1 |
| Ciciora, SL | 1 |
| Fathi, O | 1 |
| Campion, GH | 1 |
| Hoffman, RS | 6 |
| Cormier, M | 1 |
| Lavergne, V | 1 |
| Mowry, JB | 1 |
| Roberts, DM | 1 |
| Ghannoum, M | 1 |
| Su, MK | 1 |
| Gosselin, S | 1 |
| Wong, A | 1 |
| Homer, N | 1 |
| Dear, JW | 4 |
| Choy, KW | 1 |
| Doery, J | 1 |
| Graudins, A | 1 |
| Moon, J | 1 |
| Chun, B | 1 |
| Cho, Y | 1 |
| Lee, S | 1 |
| Jung, E | 1 |
| Avau, B | 1 |
| Borra, V | 1 |
| Vanhove, AC | 1 |
| Vandekerckhove, P | 1 |
| De Paepe, P | 1 |
| De Buck, E | 1 |
| Ikhile, I | 1 |
| Chijioke-Nwauche, I | 1 |
| Orisakwe, OE | 1 |
| Brown, JA | 1 |
| Wylie, CE | 1 |
| Dawson, AH | 5 |
| Isbister, GK | 2 |
| Wang, GS | 1 |
| Deakyne, S | 1 |
| Bajaj, L | 1 |
| Yin, S | 1 |
| Heard, K | 2 |
| Roosevelt, G | 1 |
| Jang, HS | 1 |
| Kim, JY | 1 |
| Choi, SH | 1 |
| Yoon, YH | 1 |
| Moon, SW | 1 |
| Hong, YS | 1 |
| Lee, SW | 1 |
| Emmett, M | 1 |
| Bateman, DN | 11 |
| Thanacoody, HK | 1 |
| Thomas, SH | 5 |
| Eddleston, M | 3 |
| Sandilands, EA | 1 |
| Coyle, J | 1 |
| Cooper, JG | 1 |
| Rodriguez, A | 1 |
| Butcher, I | 1 |
| Lewis, SC | 1 |
| Vliegenthart, AD | 1 |
| Veiraiah, A | 1 |
| Webb, DJ | 1 |
| Gray, A | 1 |
| Inoue, Y | 1 |
| Koppen, A | 1 |
| van Riel, A | 1 |
| de Vries, I | 1 |
| Meulenbelt, J | 1 |
| Ward, J | 1 |
| Kanchagar, C | 1 |
| Veksler-Lublinsky, I | 1 |
| Lee, RC | 1 |
| McGill, MR | 1 |
| Jaeschke, H | 1 |
| Curry, SC | 1 |
| Ambros, VR | 1 |
| Balasubramanian, S | 1 |
| Ramesh, V | 1 |
| Furmaga, J | 1 |
| Wax, P | 1 |
| Kleinschmidt, K | 1 |
| Skinner, A | 1 |
| Bates, N | 1 |
| Rawson-Harris, P | 1 |
| Edwards, N | 2 |
| Teraoka, H | 1 |
| Moore, C | 1 |
| Crowley, E | 1 |
| Doyle, J | 1 |
| Okafor, I | 1 |
| McNamara, R | 1 |
| Deiratany, S | 1 |
| Nicholson, AJ | 1 |
| Camilleri, R | 1 |
| Vaida, AJ | 1 |
| Villano, JH | 1 |
| O'Connell, CW | 1 |
| Ly, BT | 2 |
| Schneir, A | 1 |
| Altyar, A | 1 |
| Kordi, L | 1 |
| Skrepnek, G | 1 |
| Park, BK | 1 |
| Antoine, DJ | 1 |
| Genzen, JR | 1 |
| Hunsaker, JJ | 1 |
| Nelson, LS | 2 |
| Faine, BA | 1 |
| Krasowski, MD | 1 |
| Donkor, J | 1 |
| Armenian, P | 1 |
| Hartman, IN | 1 |
| Vohra, R | 1 |
| Fukumoto, M | 2 |
| Heard, KJ | 1 |
| Hamwi, I | 1 |
| Picksak, G | 1 |
| Stichtenoth, DO | 1 |
| Holubek, WJ | 1 |
| Goldfarb, DS | 1 |
| Mégarbane, B | 1 |
| Deye, N | 1 |
| Baud, FJ | 1 |
| Farmer, BM | 1 |
| Waring, WS | 2 |
| Nogué-Xarau, S | 1 |
| Castanyer-Puig, B | 1 |
| Barceló-Martín, B | 1 |
| Leiner, S | 1 |
| Senarathna, SM | 1 |
| Ranganathan, SS | 1 |
| Buckley, N | 2 |
| Fernandopulle, BM | 1 |
| Benhalim, S | 1 |
| Caballero Vallés, PJ | 1 |
| Dorado Pombo, S | 1 |
| Díaz Brasero, A | 1 |
| García Gil, ME | 1 |
| Yubero Salgado, L | 1 |
| Torres Pacho, N | 1 |
| Ibero Esparza, C | 1 |
| Cantero Bengoechea, J | 1 |
| Kimlin, EJ | 1 |
| Easter, JS | 1 |
| Ganetsky, M | 1 |
| Hawton, K | 6 |
| Bergen, H | 2 |
| Simkin, S | 5 |
| Brock, A | 1 |
| Griffiths, C | 3 |
| Romeri, E | 1 |
| Smith, KL | 1 |
| Kapur, N | 2 |
| Gunnell, D | 3 |
| Sebe, A | 1 |
| Satar, S | 1 |
| Rana Alpay, N | 1 |
| Murt, M | 1 |
| Güvenç, B | 1 |
| Betten, DP | 1 |
| Burner, EE | 1 |
| Thomas, SC | 1 |
| Tomaszewski, C | 2 |
| Clark, RF | 2 |
| Koliou, M | 1 |
| Ioannou, C | 1 |
| Andreou, K | 1 |
| Petridou, A | 1 |
| Soteriades, ES | 1 |
| Akahori, F | 1 |
| Mas, A | 1 |
| Escorsell, A | 1 |
| Fernández, J | 1 |
| Ott, P | 4 |
| Schmidt, LE | 2 |
| Clemmesen, JO | 3 |
| Rolff, HC | 1 |
| Christensen, HR | 2 |
| Cantrell, FL | 1 |
| Clark, R | 2 |
| Brok, J | 1 |
| Gluud, C | 1 |
| Mathieu-Nolf, M | 1 |
| Mathieu, D | 1 |
| Ballali-Mood, M | 1 |
| Oakley, E | 1 |
| Robinson, J | 1 |
| Deasy, C | 1 |
| Limjindaporn, C | 1 |
| Gray, T | 1 |
| Dougherty, PP | 1 |
| Klein-Schwartz, W | 2 |
| Blackford, MG | 1 |
| Felter, T | 1 |
| Gothard, MD | 1 |
| Reed, MD | 1 |
| Meyer, MR | 1 |
| Welter, J | 1 |
| Weber, AA | 1 |
| Maurer, HH | 1 |
| Mullins, ME | 1 |
| Vitkovitsky, IV | 1 |
| Wittebole, X | 1 |
| Hantson, P | 2 |
| Rajasuriya, M | 1 |
| Asanthi, MA | 1 |
| Ranaweera, N | 1 |
| Kmietowicz, Z | 1 |
| van Leeuwen, WA | 1 |
| Schellens, JH | 1 |
| Becker, HE | 1 |
| de Haan, L | 1 |
| van Westrhenen, R | 1 |
| Cheng, DR | 1 |
| Ip, CC | 1 |
| McIntyre, S | 1 |
| McD Taylor, D | 1 |
| Greene, S | 1 |
| Dodd, S | 1 |
| Pocock, P | 1 |
| Bernal, W | 1 |
| Dillon, C | 1 |
| Hoppu, K | 1 |
| Riordan, M | 1 |
| Rylance, G | 1 |
| Berry, K | 1 |
| Von Mach, MA | 1 |
| Lauterbach, M | 1 |
| Kaes, J | 1 |
| Hengstler, JG | 1 |
| Weilemann, LS | 1 |
| Whyte, IM | 3 |
| Seldon, M | 1 |
| Mokhlesi, B | 1 |
| Leikin, JB | 1 |
| Murray, P | 1 |
| Corbridge, TC | 1 |
| Dargan, PI | 4 |
| Jones, AL | 5 |
| Deeks, J | 1 |
| Yip, L | 1 |
| Dart, RC | 3 |
| Ashtekar, CS | 1 |
| Vyas, H | 1 |
| Balit, CM | 1 |
| Daly, FF | 1 |
| Gahagan, LD | 1 |
| Hatlestad, D | 1 |
| Hender, EA | 2 |
| Raftos, J | 1 |
| Ng, KC | 1 |
| Benson, BE | 2 |
| Cheshire, S | 1 |
| McKinney, PE | 2 |
| Litovitz, TL | 2 |
| Tandberg, D | 1 |
| Foster, H | 1 |
| Camidge, DR | 1 |
| Wood, RJ | 1 |
| Schneir, AB | 1 |
| Prescott, LF | 7 |
| Møller, LR | 1 |
| Nielsen, GL | 1 |
| Olsen, ML | 1 |
| Thulstrup, AM | 1 |
| Mortensen, JT | 1 |
| Sørensen, HT | 1 |
| Nadarajah, P | 1 |
| Hayden, MJ | 1 |
| Hofbauer, RD | 1 |
| Holger, JS | 1 |
| McGoodwin, L | 1 |
| McKeown, T | 1 |
| Kozielewicz, D | 1 |
| Dybowska, D | 1 |
| Olczak, A | 1 |
| Nowak, W | 1 |
| Bøe, GH | 1 |
| Haga, C | 1 |
| Andrew, E | 1 |
| Berg, KJ | 1 |
| Yokoyama, T | 1 |
| Bailey, B | 1 |
| Blais, R | 1 |
| Letarte, A | 1 |
| Morgan, O | 3 |
| Majeed, A | 3 |
| Inglis, JH | 1 |
| Liu, YP | 1 |
| Fang, CC | 1 |
| Chen, WJ | 1 |
| Ni, YH | 1 |
| Reith, DM | 1 |
| Fountain, JS | 1 |
| Tilyard, M | 1 |
| Su, F | 1 |
| Schwab, S | 1 |
| Lin, R | 1 |
| Henretig, F | 2 |
| Osterhoudt, KC | 1 |
| Greene, SL | 1 |
| Fathelrahman, AI | 1 |
| Ab Rahman, AF | 1 |
| Mohd Zain, Z | 1 |
| Balit, CR | 1 |
| Wiener, SW | 1 |
| Hon, KL | 1 |
| Ho, JK | 1 |
| Leung, TF | 1 |
| Wong, Y | 1 |
| Nelson, EA | 1 |
| Fok, TF | 1 |
| Eldridge, DL | 3 |
| Dobson, T | 1 |
| Brady, W | 1 |
| Rowden, AK | 2 |
| Norvell, J | 2 |
| Kirk, MA | 2 |
| Graham, CA | 1 |
| Irons, AJ | 1 |
| Munro, PT | 1 |
| Erdman, AR | 1 |
| Olson, KR | 1 |
| Christianson, G | 1 |
| Manoguerra, AS | 1 |
| Chyka, PA | 2 |
| Caravati, EM | 1 |
| Wax, PM | 1 |
| Keyes, DC | 1 |
| Woolf, AD | 3 |
| Scharman, EJ | 1 |
| Booze, LL | 1 |
| Troutman, WG | 1 |
| Davern, TJ | 1 |
| James, LP | 1 |
| Hinson, JA | 1 |
| Polson, J | 1 |
| Larson, AM | 1 |
| Fontana, RJ | 1 |
| Lalani, E | 1 |
| Munoz, S | 1 |
| Shakil, AO | 1 |
| Lee, WM | 2 |
| Hori, Y | 2 |
| Iseki, T | 1 |
| Fukuie, C | 1 |
| Namera, A | 1 |
| Yashiki, M | 1 |
| Reid, SM | 1 |
| Neto, GM | 1 |
| Clifford, TJ | 1 |
| Randhawa, N | 1 |
| Plint, A | 1 |
| White, ML | 1 |
| Liebelt, EL | 1 |
| Stalnikowicz, R | 1 |
| Yamazaki, H | 1 |
| Nielsen, L | 1 |
| Shaw, M | 1 |
| Morris, J | 1 |
| Morgan, OW | 1 |
| Good, AM | 1 |
| Kelly, CA | 1 |
| Hawkins, LC | 1 |
| Edwards, JN | 1 |
| Gude, AB | 1 |
| Hoegberg, LC | 1 |
| Pedersen, M | 1 |
| Nielsen, J | 1 |
| Angelo, HR | 1 |
| Wolf, SJ | 1 |
| Sloan, EP | 1 |
| Jagoda, AS | 1 |
| Hubalewska-Dydejczyk, A | 1 |
| Pach, D | 1 |
| Gawlikowski, T | 1 |
| Lenda-Tracz, W | 1 |
| Chwaluk, P | 1 |
| Szurkowska, M | 1 |
| Huszno, B | 1 |
| Hawkins, L | 1 |
| Dargan, P | 1 |
| Miller, MA | 1 |
| Navarro, M | 1 |
| Bird, SB | 1 |
| Donovan, JL | 1 |
| Hovda, KE | 1 |
| Bjornaas, MA | 1 |
| Skog, K | 1 |
| Opdahl, A | 1 |
| Drottning, P | 1 |
| Ekeberg, O | 1 |
| Jacobsen, D | 1 |
| Takayama, M | 1 |
| Fujisawa, M | 1 |
| Oda, A | 1 |
| Katsuyama, S | 1 |
| Hirose, Y | 1 |
| Yamazaki, K | 1 |
| Wakabayashi, H | 1 |
| Valman, HB | 1 |
| Lawson, GR | 1 |
| Craft, AW | 2 |
| Jackson, RH | 2 |
| Strong, JM | 1 |
| Henry, J | 1 |
| Volans, G | 2 |
| Meredith, TJ | 2 |
| Vale, JA | 3 |
| Stewart, MJ | 1 |
| Smith, AF | 1 |
| Bolton, DA | 1 |
| Irving, JB | 1 |
| Paulozzi, LJ | 1 |
| Hopkins, S | 1 |
| Pflüger, KH | 1 |
| Raper, S | 1 |
| Crome, P | 1 |
| Vale, A | 1 |
| Helliwell, M | 1 |
| Widdop, B | 5 |
| Follath, F | 1 |
| Goulding, R | 5 |
| Spooner, JB | 2 |
| Myers, JB | 1 |
| Smith, AJ | 2 |
| Elliott, RL | 1 |
| MacAskill, P | 1 |
| Nicol, RG | 1 |
| Jackson, JE | 1 |
| Picchioni, AL | 1 |
| Chin, L | 1 |
| Atwood, SJ | 1 |
| Ring-Larsen, H | 1 |
| Tage-Jensen, U | 2 |
| Krarup, HB | 1 |
| Lomholdt, JD | 1 |
| Mosbech, J | 1 |
| Lystbaek, BB | 2 |
| Svendsen, LB | 2 |
| Heslet, L | 2 |
| Larsen, FS | 1 |
| Hansen, BA | 1 |
| Tenenbein, M | 5 |
| Wasserman, GS | 1 |
| Tomassoni, AJ | 1 |
| Chan, TY | 4 |
| Chan, AY | 1 |
| Ho, CS | 1 |
| Critchley, JA | 1 |
| Singer, AJ | 1 |
| Carracio, TR | 1 |
| Mofenson, HC | 4 |
| Rose, SR | 1 |
| Holley, JE | 1 |
| Mandrell, TD | 1 |
| Sugathan, P | 1 |
| van Berge Henegouwen, GP | 1 |
| Savelkoul, TJ | 1 |
| Jonville-Béra, AP | 1 |
| Autret, E | 1 |
| Botting, CH | 1 |
| Smilkstein, MJ | 2 |
| Bond, GR | 2 |
| Requa, RK | 1 |
| Krenzelok, EP | 4 |
| Normann, SA | 1 |
| Tendler, JD | 1 |
| Morris, CL | 1 |
| McCoy, DJ | 1 |
| Thompson, MW | 1 |
| McCarthy, T | 1 |
| Roblez, J | 1 |
| Van Vyve, T | 1 |
| Deckers, O | 1 |
| Mahieu, P | 1 |
| Anker, AL | 1 |
| Henretig, FM | 1 |
| Day, A | 1 |
| Abbott, GD | 1 |
| Dancocks, A | 1 |
| Brent, J | 1 |
| Spooner, J | 1 |
| Chamberlain, JM | 1 |
| Gorman, RL | 1 |
| Oderda, GM | 1 |
| Klein, BL | 1 |
| Walson, PD | 1 |
| Groth, JF | 1 |
| Claass, A | 1 |
| Gaude, M | 1 |
| Schröder, H | 1 |
| Larsen, LC | 1 |
| Fuller, SH | 1 |
| Rumbeiha, WK | 1 |
| Lin, YS | 1 |
| Oehme, FW | 1 |
| Schiødt, FV | 3 |
| Bondesen, S | 2 |
| Tygstrup, N | 2 |
| De Roos, FJ | 1 |
| Filipović-Grcić, B | 1 |
| Novak, M | 1 |
| Sarić, D | 1 |
| Delija-Presecki, Z | 1 |
| Plavsić, F | 1 |
| Turk, R | 1 |
| Dujsin, M | 1 |
| Langdon, DE | 1 |
| Goepp, JG | 1 |
| Dean, BS | 1 |
| Bricker, JD | 1 |
| Webster, PA | 1 |
| Roberts, DW | 1 |
| Benson, RW | 1 |
| Kearns, GL | 1 |
| Sporer, KA | 2 |
| Khayam-Bashi, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Trial to Assess the Effectiveness of Pre-treatment With Ondansetron at Reducing Nausea and Vomiting in Patients Treated With Either the Conventional Regimen or a Modified Regimen of Acetylcysteine for Paracetamol Poisoning[NCT01050270] | Phase 4 | 222 participants (Actual) | Interventional | 2010-09-30 | Completed | ||
| Treatment of Acetaminophen Toxicity With Intravenous vs Oral N-acetylcysteine: A Retrospective Review[NCT00725179] | 130 participants (Anticipated) | Observational | 2008-08-31 | Completed | |||
| A Pilot Trial to Determine the Effective Dose of N-acetylcysteine for Opioid Reduction in Patients Undergoing Spine Surgery.[NCT04562597] | Phase 1/Phase 2 | 50 participants (Actual) | Interventional | 2021-01-20 | Completed | ||
| Divided Drug Delivery : a Way to Prevent Repeated Volutary Drug Intoxications.[NCT02869724] | 30 participants (Anticipated) | Interventional | 2014-03-31 | Recruiting | |||
| Treatment of Acetaminophen Toxicity With Intravenous vs. Oral N-acetylcysteine: A Retrospective Review[NCT01465542] | 47 participants (Actual) | Observational | 2011-06-30 | Completed | |||
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| Aminotransferase Trends During Prolonged Therapeutic Acetaminophen Dosing[NCT00743093] | Phase 4 | 398 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| [NCT00799578] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Post operative opioid consumption in the 12 hours that occur post-operatively. (NCT04562597)
Timeframe: 12 hours
| Intervention | IV morphine mg equivalents (Mean) |
|---|---|
| Placebo | 19.4 |
| N-acetylcysteine (NAC) | 15.6 |
Post operative opioid consumption ry 6 hours post operative. Data are reported as mean (95% CI) or mean difference (95% CI) estimated from a linear mixed model of opioid consumption over time including main effects for treatment group, postoperative time, and the interaction between treatment group and postoperative time and a random subject effect. (NCT04562597)
Timeframe: 6-48 hours
| Intervention | IV morphine mg equivalents (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| 6 hours | 18 hours | 24 hours | 30 hours | 36 hours | 42 | 48 | |
| N-acetylcysteine (NAC) | 12.0 | 19.9 | 24.7 | 27.2 | 29.7 | 33.1 | 34.9 |
| Placebo | 14.6 | 25.0 | 29.6 | 34.0 | 37.9 | 40.9 | 43.3 |
ALT was measured on Day 0 and 16 for all study participants. Subjects with an elevated ALT at Day 16 continued dosing with study drug and continued to have their ALT measured every three days until the ALT elevation resolved or until Day 40. Persistent ALT elevation was defined as any subject with an unresolved ALT elevation at study Day 40. (NCT00743093)
Timeframe: serial samples for 16-40 days
| Intervention | participants (Number) | |
|---|---|---|
| Subjects without persisitent ALT elevation | Subjects with persistent ALT elevation | |
| Acetaminophen Arm | 204 | 1 |
| Placebo Arm | 47 | 0 |
(NCT00743093)
Timeframe: Days 1-3
| Intervention | participants (Number) | ||
|---|---|---|---|
| Day 1-No. Subjects with Detectable APAP-cys | Day 2-No. Subjects with Detectable APAP-cys | Day 3-No. Subjects with Detectable APAP-cys | |
| Acetaminophen Arm | 7 | 57 | 59 |
| Placebo Arm | 1 | 1 | 1 |
(NCT00799578)
Timeframe: 6 months
| Intervention | participants (Number) |
|---|---|
| Number of Improved Subjects | 7 |
60 reviews available for acetaminophen and Poisoning
| Article | Year |
|---|---|
First aid interventions by laypeople for acute oral poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antidepressive Agents; Antidotes; Benzodiazepines; Carbamaz | 2018 |
Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adenosine Triphosphate; Analgesics, Non-Narcotic; An | 2014 |
[Blood concentration useful in the diagnosis and treatment of poisoning].
Topics: Acetaminophen; Aspirin; Barbiturates; Digoxin; Drug Monitoring; Humans; Inorganic Chemicals; Lithium | 2014 |
Recommendations for the paracetamol treatment nomogram and side effects of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Free Radical Scavengers; Hospi | 2014 |
Common questions in veterinary toxicology.
Topics: Acetaminophen; Animals; Antidotes; Cacao; Charcoal; Dog Diseases; Dogs; Emetics; Ethylene Glycol; Fa | 2015 |
[Current understanding of differential sensitivity of animals to toxic substances: species, strain and individual differences].
Topics: Acetaminophen; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassett | 2014 |
A meta-analysis of the reliability of the history in suspected poisoning.
Topics: Acetaminophen; Acute Disease; Cocaine; Drug Overdose; Humans; Medical History Taking; N-Methyl-3,4-m | 2015 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Gastric Lavage; Humans; Liver Transplantation; Methionine; | 2015 |
[Analytic role in clinical toxicology--impact on the diagnosis and treatment of a poisoned patient].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Drug Monitoring; Humans; Poisoni | 2008 |
Acetylcysteine for acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavenge | 2008 |
[Intravenous or oral N acetylcysteine therapy in paracetamol poisoned patients. Should treatment guidelines be reviewed?].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Drug Administration S | 2010 |
[Current topics and problems in toxicology laboratories--7: Occurrence of poisoning due to 15 chemicals and introduction of analytical methods for diphenhydramine and SSRIs].
Topics: Acetaminophen; Benzodiazepines; Chromatography, High Pressure Liquid; Diphenhydramine; Gas Chromatog | 2010 |
Acute poisoning following ingestion of medicines: initial management. How to treat life-threatening complications and to evaluate the risk of delayed effects and psychological distress.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Charcoal; Depression; Gastric Lavage; Humans; Poisonin | 2010 |
Assessment of the clinical use of intravenous and oral N-acetylcysteine in the treatment of acute acetaminophen poisoning in children: a retrospective review.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Child; Clinical Trials as Topic; | 2011 |
Use of the molecular adsorbent recirculating system (MARS™) for the management of acute poisoning with or without liver failure.
Topics: Acetaminophen; Acute Disease; Albumins; Amanita; Amphetamine; Calcium Channel Blockers; Cocaine; Hea | 2011 |
Poisoning and self-harm.
Topics: Acetaminophen; Antidotes; Cardiotonic Agents; Cardiotoxins; Delayed Diagnosis; Early Medical Interve | 2012 |
[Treatment of paracetamol intoxication. Correctly given antidote treatment will prevent liver damage].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2002 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Humans; Methionine; Poisoning; Randomized Controlled Trials as Topic; | 2002 |
Poisoning in children 2: painkillers.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspiri | 2002 |
Adult toxicology in critical care: Part II: specific poisonings.
Topics: Acetaminophen; Alcohols; Cyanides; Drug-Related Side Effects and Adverse Reactions; Emergencies; Hum | 2003 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Antidotes; Chemistry, Pharmaceu | 2003 |
[New perspectives on paracetamol].
Topics: Acetaminophen; Administration, Oral; Advertising; Analgesics, Non-Narcotic; Chemical and Drug Induce | 2003 |
Poisoning.
Topics: Acetaminophen; Antidotes; Child, Preschool; Humans; Illicit Drugs; Infant; Infant, Newborn; Iron; Me | 2004 |
Restricting paracetamol in the United Kingdom to reduce poisoning: a systematic review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug and Narcotic C | 2005 |
Acute poisoning: understanding 90% of cases in a nutshell.
Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyc | 2005 |
Trends in clinical toxicology: advances that may change your practice.
Topics: Acetaminophen; Anticoagulants; Charcoal; Chest Pain; Cocaine-Related Disorders; Ethanol; Humans; Poi | 2005 |
Utilizing diagnostic investigations in the poisoned patient.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Chemical Ana | 2005 |
Updates on acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Emergency Treatment; Humans; Liver Transplantation; Poisoni | 2005 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Humans; Poisoning | 2006 |
[Proposal of an analytical pathway for the treatment of poisonings--application of blood concentration to the evaluation of toxicity: nomogram and outcome].
Topics: Acetaminophen; Aminobutyrates; Herbicides; Humans; Nomograms; Paraquat; Poisoning; Time Factors | 2006 |
Update on antidotes for pediatric poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Antidotes; Antivenins; Child; Child | 2006 |
[Clinical poisonings and genomics].
Topics: Acetaminophen; Alcohol Dehydrogenase; Animals; Biomarkers; Cytochrome P-450 Enzyme System; Ethanol; | 2006 |
Impact of restricting paracetamol pack sizes on paracetamol poisoning in the United Kingdom: a review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Commerce; Drug Over | 2007 |
Drug analyses in poisoned patients--the need to be specific.
Topics: Acetaminophen; Barbiturates; Chlormethiazole; Clinical Laboratory Techniques; Colorimetry; Diagnosti | 1982 |
[Paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Charcoal; Denmark; Intestinal Absorption; Kidney; Liver; | 1995 |
[Acetylcysteine in paracetamol overdose; intravenous but also oral therapy is helpful even in late application].
Topics: Acetaminophen; Acetylcysteine; Humans; Poisoning; Time Factors | 1994 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Animals; Antidotes; Humans; Poisoning | 1993 |
Acetaminophen. Concepts and controversies.
Topics: Acetaminophen; Adult; Child; Female; Humans; Poisoning; Pregnancy | 1994 |
Special considerations in the poisoned pediatric patient.
Topics: Acetaminophen; Alcoholic Intoxication; Astemizole; Child; Child, Preschool; Clonidine; Cocaine; Crit | 1994 |
Management of acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Poisoning | 1996 |
Pediatric poisonings.
Topics: Acetaminophen; Adolescent; Chemistry, Clinical; Child; Child, Preschool; Emergency Medicine; Female; | 1996 |
[Clinical-toxicological case (1). Dosage of N-acetylcysteine in acute paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Antidotes; Drug Administration Schedule; Female; Humans; Poisoning | 1996 |
Hemolysis after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; H | 1996 |
[Recommendations for treatment of paracetamol poisoning. Danish Medical Society, Study of the Liver].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 1996 |
Position statement: ipecac syrup. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Animals; Antidotes; Charcoal; Child; Child, | 1997 |
Position statement: gastric lavage. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists.
Topics: Acetaminophen; Adolescent; Adult; Animals; Antidepressive Agents, Tricyclic; Barbiturates; Child; Cl | 1997 |
Mechanism of action and value of N-acetylcysteine in the treatment of early and late acetaminophen poisoning: a critical review.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Female; Free Radical Scavengers; H | 1998 |
The human and economic cost of paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cost of Illness; Drug Overdose; Humans; Liver Failure, Acut | 1995 |
When acetaminophen use becomes toxic. Treating acute accidental and intentional overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Humans; Liver Failure; Poisoning | 1999 |
Management of self poisoning.
Topics: Acetaminophen; Carbon Monoxide Poisoning; Charcoal; Emetics; Ethylene Glycol; Gastric Lavage; Humans | 1999 |
Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Cha | 1999 |
Acute intoxication with aniline: detection of acetaminophen as aniline metabolite.
Topics: Acetaminophen; Acetanilides; Acetylation; Aniline Compounds; Female; Forensic Medicine; Gas Chromato | 2000 |
Poisoning potpourri.
Topics: Acetaminophen; Age Factors; Alcohol Drinking; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac | 2001 |
Pediatric toxicologic concerns.
Topics: Acetaminophen; Antidotes; Calcium Channel Blockers; Child, Preschool; Clonidine; Decontamination; Ga | 2002 |
Use of N-acetylcysteine in clinical toxicology.
Topics: Acetaminophen; Acetylcysteine; Animals; Contraindications; Humans; Poisoning; Toxicology | 1991 |
Poisoning.
Topics: Acetaminophen; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Clonidine; Humans; Hydroca | 1988 |
Pediatric toxicology: current controversies and recent advances.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Child Ab | 1986 |
Therapeutic drug monitoring in pediatric acute drug intoxications.
Topics: Acetaminophen; Alcoholic Intoxication; Antidepressive Agents, Tricyclic; Child; Humans; Iron; Kineti | 1985 |
Haemodialysis in the treatment of acute poisoning.
Topics: Acetaminophen; Adult; Alcohols; Aniline Compounds; Arsenic Poisoning; Barbiturates; Carbon Tetrachlo | 1970 |
Treatment of salicylate poisoning.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Acute Kidney Injury; Alkalosis, Respiratory; Aspirin | 1971 |
14 trials available for acetaminophen and Poisoning
| Article | Year |
|---|---|
Paracetamol metabolite concentrations following low risk overdose treated with an abbreviated 12-h versus 20-h acetylcysteine infusion.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Biotransforma | 2019 |
Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Antiemetics; Double-Blind Method; | 2014 |
A 20-hour treatment for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Adolescent; Adult; Drug Administ | 2003 |
Effect of whole bowel irrigation on the pharmacokinetics of an acetaminophen formulation and progression of radiopaque markers through the gastrointestinal tract.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Contrast Media; Cross-Over Studies | 2004 |
The use of cholecystokinin as an adjunctive treatment for toxin ingestion.
Topics: Acetaminophen; Adjuvants, Pharmaceutic; Analgesics, Non-Narcotic; Animals; Area Under Curve; Charcoa | 2004 |
Use of activated charcoal in a simulated poisoning with acetaminophen: a new loading dose for N-acetylcysteine?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adsorption; Adult; Biological Availability; Cha | 1993 |
Efficacy of ipecac during the first hour after drug ingestion in human volunteers.
Topics: Acetaminophen; Adult; Area Under Curve; Biological Availability; Chromatography, High Pressure Liqui | 1997 |
Gastric lavage for liquid poisons.
Topics: Acetaminophen; Adult; Cross-Over Studies; Emergency Service, Hospital; Female; Gastric Lavage; Human | 2000 |
Clinical evaluation of an acetaminophen meter for the rapid diagnosis of acetaminophen intoxication.
Topics: Acetaminophen; Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Laboratory Techniques; Eme | 1990 |
Letter: Treatment of paracetamol poisoning.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1974 |
Letter: Cysteamine for paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Blood Specimen Collection; Chemical and Drug Induced Liver Injury; Ch | 1974 |
Letter: Treatment of paracetamol overdosage.
Topics: Acetaminophen; Administration, Oral; Clinical Trials as Topic; Cysteamine; Humans; Methionine; Poiso | 1974 |
A comparison of the antipyretic effect of acetaminophen and aspirin. Another approach to poison prevention.
Topics: Acetaminophen; Age Factors; Aspirin; Body Temperature; Child, Preschool; Clinical Trials as Topic; F | 1972 |
Reduction of absorption of paracetamol by activated charcoal and cholestyramine: a possible therapeutic measure.
Topics: Acetaminophen; Administration, Oral; Charcoal; Chemical and Drug Induced Liver Injury; Cholestyramin | 1973 |
291 other studies available for acetaminophen and Poisoning
| Article | Year |
|---|---|
Paediatric exploratory ingestion presentations to Christchurch Hospital emergency department during 2019.
Topics: Accidents, Home; Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agen | 2021 |
Pediatric suicides reported to U.S. poison centers.
Topics: Acetaminophen; Adolescent; Child; Humans; Poison Control Centers; Poisoning; Poisons; Suicide | 2022 |
Classification of acute poisoning exposures with machine learning models derived from the National Poison Data System.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Benzodiazepines; Bupropion; Calc | 2022 |
A retrospective analysis of therapeutic drug exposures in New Zealand National Poisons Centre data 2018-2020.
Topics: Acetaminophen; Adolescent; Aged; Antidepressive Agents; Child; Humans; New Zealand; Poison Control C | 2023 |
The impact on poisonings of up-scheduling of modified release paracetamol to Schedule 3 (pharmacist only medicine).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Medicine; Pharmacists; Poisoning | 2023 |
Repeated poisonings in Denmark - a nationwide study.
Topics: Acetaminophen; Adult; Cyclizine; Denmark; Female; Humans; Male; Poison Control Centers; Poisoning; P | 2023 |
[Acetaminophen poisonings hospitalized at the Pomeranian Center of Toxicology in 2010-2015].
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Chemical and Drug Induced Li | 2019 |
[Simplified N-acetylcystein treatment after paracetamol overdose - new recommendations from Swedish Poisons Information Centre].
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Drug Overdose; Humans; Poison | 2019 |
[Update - intoxications in critical care medicine].
Topics: Acetaminophen; Adrenergic beta-Antagonists; Calcium Channel Blockers; Carbon; Critical Care; Humans; | 2020 |
Fatal acetaminophen poisoning with hepatic microvesicular steatosis in a child after repeated administration of therapeutic doses.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Diagnosis, Differential; Female; Foren | 2020 |
Trends in emergency department visits for acetaminophen-related poisonings: 2011-2019.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Analgesics, Non-Narcotic; Canada; Child; Child, | 2020 |
Malnourishment-Associated Acetaminophen Toxicity in Pregnancy.
Topics: Acetaminophen; Acidosis; Adult; Diagnosis, Differential; Female; Humans; Malnutrition; Poisoning; Pr | 2021 |
[Unusual cause of a PCT-elevation].
Topics: Abdominal Pain; Acetaminophen; Acetylcysteine; Adult; Diagnosis, Differential; Female; Humans; Nause | 2021 |
[Access to rapid laboratory analytical services in cases of acute poisoning provides better and safer patient care].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Clinical Laboratory Services; Healthcare Disparities; Human | 2017 |
Acetaminophen Poisoning May Increase Coronary Artery Disease Risk: A Nationwide Cohort Study.
Topics: Acetaminophen; Adult; Age Factors; Analgesics, Non-Narcotic; Case-Control Studies; Comorbidity; Coro | 2018 |
Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; F | 2018 |
Efficient diagnosis and treatment of acute paracetamol poisoning: cost-effectiveness analysis of approaches based on a hospital toxicovigilance program.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Cost-Benefit | 2018 |
Accidental or intentional exposure to potentially toxic medications, natural toxins and chemicals during pregnancy: analysis of data from Tox Info Suisse.
Topics: Accidents; Acetaminophen; Adult; Databases, Factual; Environmental Exposure; Female; Hazardous Subst | 2018 |
Epidemiology of paediatric poisoning presenting to a children's emergency department in Singapore over a five-year period.
Topics: Acetaminophen; Adolescent; Adult; Child; Child, Preschool; Critical Care; Drug Overdose; Emergency S | 2018 |
Acetaminophen Poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Poisoning | 2018 |
Acetaminophen and Acetylsalicylic Acid Exposure in a Preterm Infant after Maternal Overdose.
Topics: Acetaminophen; Antidepressive Agents; Antidotes; Aspirin; Cystine; Drug Overdose; Female; Humans; In | 2019 |
Extracorporeal treatments in poisonings from four non-traditionally dialysed toxins (acetaminophen, digoxin, opioids and tricyclic antidepressants): A combined single-centre and national study.
Topics: Acetaminophen; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Databases, Factual; Digoxin; Hu | 2019 |
Characteristics of Emergency Department Presentations of Pediatric Poisoning Between 2011 and 2016: A Retrospective Observational Study in South Korea.
Topics: Acetaminophen; Child; Emergency Service, Hospital; Family; Humans; Infant; Poisoning; Republic of Ko | 2021 |
Childhood Drug and Non-Drug Poisoning in Nigeria: An Economic Appraisal.
Topics: Acetaminophen; Adolescent; Age Distribution; Amitriptyline; Analgesics, Non-Narcotic; Antipsychotic | 2019 |
[Improved and harmonised laboratory analysis of paracetamol provides safer assessment of poisoning cases].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Clinical Laboratory Services; Dr | 2019 |
Paracetamol poisoning-related hospital admissions and deaths in Australia, 2004-2017.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Australia; Chil | 2019 |
The limited utility of screening laboratory tests and electrocardiograms in the management of unintentional asymptomatic pediatric ingestions.
Topics: Acetaminophen; Asymptomatic Diseases; Blood Cell Count; Blood Chemical Analysis; Child; Child, Presc | 2013 |
Comparative analysis of acute toxic poisoning in 2003 and 2011: analysis of 3 academic hospitals.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Child; Child, Preschool | 2013 |
Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Hepatitis; Humans; Ischemia; MicroRNAs; Poisoni | 2014 |
Paracetamol--high strength formulations and toxicity.
Topics: Acetaminophen; Antipyretics; Dosage Forms; Humans; Poisoning | 2014 |
N-Acetylcysteine (NAC)-Induced Hyponatremia Caused by an Electronic Medical Record (EMR) Order Error.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Biomarkers; Electronic Health Records; Epilepsy, Tonic-Clo | 2015 |
Paracetamol overdose.
Topics: Acetaminophen; Analgesics; Drug Overdose; Humans; Poisoning; United Kingdom | 2015 |
New hazards in paediatric poisoning presentations.
Topics: Acetaminophen; Charcoal; Child, Preschool; Databases, Factual; Hospitals, Pediatric; Household Produ | 2015 |
The Institute for Safe Medication Practices and Poison Control Centers: Collaborating to Prevent Medication Errors and Unintentional Poisonings.
Topics: Academies and Institutes; Acetaminophen; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Na | 2015 |
Case Files from the University of California San Diego Health System Fellowship Coma and Severe Acidosis: Remember to Consider Acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Antidotes; Biomarkers; Coma; Drug Overdose; | 2015 |
Clinical and economic characteristics of emergency department visits due to acetaminophen toxicity in the USA.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cross-Sectional | 2015 |
N-acetylcysteine interference of Trinder-based assays.
Topics: Acetaminophen; Acetylcysteine; Ferric Compounds; Humans; Poisoning; Retrospective Studies | 2016 |
Analysis of Gastric Lavage Reported to a Statewide Poison Control System.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2016 |
[Accidental acetaminophen overdose].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2008 |
Use of hemodialysis and hemoperfusion in poisoned patients.
Topics: Acetaminophen; Carbamazepine; Ethylene Glycol; Hemoperfusion; Humans; Lithium; Poisoning; Poisons; R | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Hum | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Ambulatory Care; Anti-Inflammatory Agents, Non- | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Hum | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Hal | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Hum | 2008 |
Management of acute paracetamol poisoning in a tertiary care hospital.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Analgesics, Non-Narcotic; Antidotes; Charcoal; Emetics | 2008 |
Serum acetaminophen concentrations after acute overdose are not altered by opioid co-ingestion.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Int | 2008 |
[Epidemiologic survey of acute poisoning in the south area of the Community of Madrid: the VEIA 2004 study].
Topics: Accidents, Home; Accidents, Occupational; Acetaminophen; Acute Disease; Adolescent; Adult; Age Facto | 2008 |
A 46-year-old woman with altered mental status and garbled speech.
Topics: Acetaminophen; Acetylcysteine; Diagnosis, Differential; Diphenhydramine; Electrocardiography; Female | 2009 |
Effect of withdrawal of co-proxamol on prescribing and deaths from drug poisoning in England and Wales: time series analysis.
Topics: Acetaminophen; Analgesics; Dextropropoxyphene; Drug Approval; Drug Combinations; England; Humans; Mo | 2009 |
Limiting paracetamol pack size: has it worked in the UK?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Canada; Commerce; Dose-Response Relationship, Drug; Drug Ov | 2009 |
Severe acetaminophen poisoning treated with a fractionated plasma separation and absorption system: A case report.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Female; Humans; Liver Function Tests; Plasmapheresis; Poi | 2009 |
A retrospective evaluation of shortened-duration oral N-acetylcysteine for the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Non-Narcot | 2009 |
Fatal poisoning among young children from diethylene glycol-contaminated acetaminophen - Nigeria, 2008-2009.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Drug Contamination; Drug I | 2009 |
The epidemiology of childhood poisonings in Cyprus.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Cyprus; Drug-Related S | 2010 |
[Application in veterinary and human clinical toxicology].
Topics: Acetaminophen; Aflatoxins; Animals; Biphenyl Compounds; Cat Diseases; Cats; Chickens; Ethylene Glyco | 2009 |
Liver transplantation for acute liver failure: a Spanish perspective.
Topics: Acetaminophen; Emergencies; Humans; Liver Failure, Acute; Liver Transplantation; Poisoning; Spain | 2010 |
[Treatment of paracetamol poisoning to revision].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Poisoning; Practice | 2010 |
Intravenous and enteral N-acetylcysteine can be both cost effective.
Topics: Acetaminophen; Acetylcysteine; Cost-Benefit Analysis; Humans; Infusions, Intravenous; Infusions, Par | 2010 |
[Comment of the paracetamol debate--next step].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Humans; Infusions, In | 2010 |
[Acute poisonings: general management and main causes].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Antidepressive Agents; Cardiovascular Agents | 2010 |
Major reductions in global suicide numbers can be made rapidly through pesticide regulation without the need for psychosocial interventions.
Topics: Acetaminophen; Agriculture; Cognition; Developing Countries; Global Health; Government Regulation; H | 2011 |
Why not formulate an acetaminophen tablet containing N-acetylcysteine to prevent poisoning?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemistry, Pharmaceutical; Delay | 2011 |
Using 0.45% saline solution and a modified dosing regimen for infusing N-acetylcysteine in children with paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Child; Combined Modality Therapy; Drug Administration Schedule; Emerg | 2011 |
Acute poison exposure in the emergency department: a 2-year study in a university hospital.
Topics: Acetaminophen; Adolescent; Adult; Child; Child, Preschool; Emergency Service, Hospital; Female; Hosp | 2010 |
Intravenous paracetamol--an international perspective of toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Injections, Intravenous; Internation | 2011 |
Unexpected late rise in plasma acetaminophen concentrations with change in risk stratification in acute acetaminophen overdoses.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Charcoal; Che | 2012 |
Development, validation, and application of a fast and simple GC-MS method for determination of some therapeutic drugs relevant in emergency toxicology.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Gas Chromatography-Mass Spe | 2011 |
Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Female; Hemolysis; Hemolytic-Uremic Syndr | 2011 |
A descriptive study on self-poisoning in Ampara.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Agrochemicals; Analgesics, Non-Narcotic; Female; | 2012 |
Suicides involving co-proxamol fell dramatically after withdrawal in UK.
Topics: Acetaminophen; Analgesics; Dextropropoxyphene; Drug Combinations; Humans; Poisoning; Safety-Based Dr | 2012 |
[The subclinical course of a paracetamol intoxication: pitfall for patient and clinician].
Topics: Acetaminophen; Acetylcysteine; Humans; Liver; Male; Poisoning; Time Factors; Young Adult | 2012 |
Unintentional paediatric poisoning in rural Victoria: incidence and admission rates.
Topics: Accidents; Acetaminophen; Adolescent; Age Factors; Child; Child, Preschool; Drug Overdose; Emergency | 2012 |
Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Australia; Body Weight; Drug Dosage | 2013 |
Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug I | 2013 |
Gastrointestinal decontamination in paediatric exploratory ingestions.
Topics: Acetaminophen; Charcoal; Child, Preschool; Decontamination; Emergency Service, Hospital; Female; Hos | 2002 |
[Deliberate self-poisoning with paracetamol (acetaminophen): an analysis from 1995 to 2002].
Topics: Acetaminophen; Adult; Female; Germany; Humans; Incidence; Length of Stay; Male; Poisoning; Retrospec | 2003 |
Effect of paracetamol poisoning on international normalised ratio.
Topics: Acetaminophen; Acetylcysteine; Factor IX; Factor VII Deficiency; Humans; International Normalized Ra | 2003 |
Co-proxamol and suicide: a study of national mortality statistics and local non-fatal self poisonings.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Antidepressive Agents, Tricyclic; Child; Dextrop | 2003 |
Warning note on a blood gas report leading to diagnosis of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Blood Glucose; Dextropropoxyphe | 2003 |
The effect of recalling paracetamol on hospital admissions for poisoning.
Topics: Acetaminophen; Confounding Factors, Epidemiologic; Drug and Narcotic Control; Humans; Patient Admiss | 2003 |
Delayed poisoning emergencies.
Topics: Acetaminophen; Antidepressive Agents, Tricyclic; Child; Delayed-Action Preparations; Dietary Supplem | 2003 |
The effect of recalling paracetamol on hospital admissions for poisoning.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Drug and Narcoti | 2003 |
Paracetamol ingestions at the Children's Emergency Department--a three year series.
Topics: Acetaminophen; Adolescent; Child; Child, Preschool; Emergencies; Female; Humans; Infant; Male; Poiso | 2003 |
Do poison center guidelines adversely affect patient outcomes as triage referral values increase?
Topics: Acetaminophen; Humans; Iron; Outcome Assessment, Health Care; Poison Control Centers; Poisoning; Pra | 2003 |
The epidemiology of self-poisoning in the UK.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Female; Humans; Male; Poisoning; Self-In | 2003 |
Hospital discharges and 30-day case fatality for drug poisoning: a Danish population-based study from 1979 to 2002 with special emphasis on paracetamol.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Denmark; Fema | 2004 |
Poisoning trends and the importance of educating patients about poison prevention.
Topics: Accidents, Home; Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Confi | 2004 |
Acute hepatic failure in the course of alcohol-paracetamol syndrome--case report.
Topics: Acetaminophen; Acetylcysteine; Ethanol; Humans; Liver Failure, Acute; Male; Middle Aged; Poisoning | 2003 |
[Paracetamol poisonings in Norway 1990-2001].
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Cause of Death; Child; Child, Pres | 2004 |
[For which cases should clinicians perform blood purification in the management of acute poisoning? Clinical and pharmacological analyses].
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Cost-Benefit Analysis; Fem | 2004 |
Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Child, Preschool; Drug Overdose; Fatal Outc | 2004 |
Impact of paracetamol pack size restrictions on poisoning from paracetamol in England and Wales: an observational study.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Aged; Analgesics, Non-Narcotic; Child; Child, Pr | 2005 |
Restricting sales of paracetamol tablets: effect on deaths and emergency admissions for poisoning in Scotland 1991 - 2002.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug and Narcotic Control; Emergencies; Humans; Poisoning; | 2004 |
Fulminant hepatic failure due to chronic acetaminophen intoxication in an infant.
Topics: Acetaminophen; Acetylcysteine; Chronic Disease; Emergency Medicine; Female; Humans; Infant; Liver Fa | 2005 |
'Opioid poisoning deaths in New Zealand (2001-2002)' and the UK's recent decision to withdraw the pain killer coproxamol.
Topics: Acetaminophen; Dextropropoxyphene; Drug and Narcotic Control; Drug Combinations; Drug Overdose; Huma | 2005 |
A toddler with obtundation and miosis.
Topics: Acetaminophen; Child, Preschool; Humans; Male; Miosis; Poisoning; Unconsciousness | 2005 |
MS 04-044: demographic features of drug and chemical poisoning in northern Malaysia.
Topics: Accidents; Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Asian People; Dem | 2005 |
Which medicines do young children access from blister packs?
Topics: Accidents, Home; Acetaminophen; Child, Preschool; Contraceptives, Oral; Drug Packaging; Humans; New | 2005 |
Review of children hospitalised for ingestion and poisoning at a tertiary centre.
Topics: Acetaminophen; Child; Child, Preschool; Female; Hospitalization; Humans; Male; Poisoning; Singapore; | 2005 |
Paracetamol and salicylate testing: routinely required for all overdose patients?
Topics: Acetaminophen; Drug Overdose; Emergency Service, Hospital; Humans; Poisoning; Prospective Studies; S | 2006 |
Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management.
Topics: Acetaminophen; Ambulatory Care; Analgesics, Non-Narcotic; Antidotes; Evidence-Based Medicine; Humans | 2006 |
Measurement of serum acetaminophen-protein adducts in patients with acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Blood Proteins; Chromatography, High Pressure Liquid; Fem | 2006 |
Measurement of serum acetaminophen-protein adducts in patients with acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Blood Proteins; Chromatography, High Pressure Liquid; Fem | 2006 |
Measurement of serum acetaminophen-protein adducts in patients with acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Blood Proteins; Chromatography, High Pressure Liquid; Fem | 2006 |
Measurement of serum acetaminophen-protein adducts in patients with acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Blood Proteins; Chromatography, High Pressure Liquid; Fem | 2006 |
Use of single-dose activated charcoal among Canadian pediatric emergency physicians.
Topics: Acetaminophen; Adolescent; Antidotes; Canada; Charcoal; Child, Preschool; Cross-Sectional Studies; D | 2006 |
[Practice of toxicology screening in an emergency department].
Topics: Acetaminophen; Biomarkers; Carboxyhemoglobin; Dronabinol; Emergency Service, Hospital; Humans; Poiso | 2006 |
What is your diagnosis? Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Blood Chemical Analysis; Blood Gas | 2007 |
Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Antidepressive Agents; Aspirin; Causality; Death Certific | 2007 |
Does restricting pack size of paracetamol (acetaminophen) reduce suicides?
Topics: Acetaminophen; Adult; Antidepressive Agents; Aspirin; Automobiles; Carbon Monoxide Poisoning; Causal | 2007 |
Differences in treatment advice for common poisons by poisons centres--an international comparison.
Topics: Acetaminophen; Antidotes; Charcoal; Decontamination; Emergency Treatment; Gastric Lavage; Humans; In | 2007 |
[A study of 355 consecutive acute poisoning cases admitted to an emergency ward at Copenhagen University Hospital, Bispebjerg in 2001].
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Alcoholic Intoxication; Analgesics, Non-Narco | 2007 |
Clinical policy: critical issues in the management of patients presenting to the emergency department with acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Eme | 2007 |
[Quantitative analysis of heart scintigraphy (99mTc-MIBI GSPECT) with regional myocardial wall motion and thickening assessment for detecting myocardial injury in patients after acute paracetamol poisoning].
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Female; Gated Blood-Pool Imaging; Humans; Image Int | 2007 |
Paracetamol (acetaminophen) pack size restrictions and poisoning severity: time trends in enquiries to a UK poisons centre.
Topics: Acetaminophen; Age Distribution; Analgesics, Non-Narcotic; Drug Overdose; Drug Packaging; Female; Hu | 2007 |
Antiemetic use in acetaminophen poisoning: how does the route of N-acetylcysteine administration affect utilization?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Antidotes; Ant | 2007 |
Acute poisonings treated in hospitals in Oslo: a one-year prospective study (I): pattern of poisoning.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Opioid; Benzodia | 2008 |
[Clinical usefulness of the acetaminophen detection kit in treating acute poisoning--data from a survey of 28 cases treated at Niigata City general hospital].
Topics: Acetaminophen; Acute Disease; Hospitals, Urban; Humans; Japan; Poisoning; Reagent Kits, Diagnostic | 2008 |
ABC of 1 to 7. Poisoning.
Topics: Acetaminophen; Alcoholic Intoxication; Antidepressive Agents, Tricyclic; Barbiturates; Belladonna Al | 1982 |
Changing pattern of poisoning in children in Newcastle, 1974-81.
Topics: Acetaminophen; Adolescent; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; C | 1983 |
New approaches in managing drug overdosage and poisoning.
Topics: Acetaminophen; Acetylcysteine; Adrenergic beta-Antagonists; Adult; Analgesics, Opioid; Child; Cholin | 1983 |
Changing trends in drug overdose over a six-year period.
Topics: Acetaminophen; Adolescent; Adult; Benzodiazepines; Female; Humans; Male; Middle Aged; Military Medic | 1984 |
ABC of poisoning. Problems in children.
Topics: Acetaminophen; Antidotes; Child; Child, Preschool; Female; Gastric Lavage; Humans; Infant; Milk, Hum | 1984 |
Epidemiology of analgesic overdose in England and Wales.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Aspirin; Child; Child, Preschool; Data Collectio | 1984 |
Review of drug overdosage in West Lothian.
Topics: Acetaminophen; Adolescent; Adult; Aged; Benzodiazepines; Female; Humans; Male; Middle Aged; Poisonin | 1983 |
Seasonality of reported poison exposures.
Topics: Acetaminophen; Aspirin; Bites and Stings; Child; Child, Preschool; Humans; Insecticides; New Hampshi | 1983 |
Paracetamol.
Topics: Acetaminophen; Acetylcysteine; Humans; Methionine; Poisoning | 1980 |
[Toxicology and therapy of paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Cysteamine; Drug Interactions; Ethanol; Gastric Lavage; Glutathione; | 1980 |
Experience with activated carbon-bead haemoperfusion columns in the treatment of severe drug intoxication. A preliminary report.
Topics: Acetaminophen; Adolescent; Adult; Aged; Charcoal; Female; Glutethimide; Hemoperfusion; Humans; Pheno | 1982 |
[Assays of serum concentrations in drug intoxications].
Topics: Acetaminophen; Barbiturates; Humans; Meprobamate; Poisoning; Salicylates | 1982 |
Liaison with industry in the provision of essential information for the management of poisoning. II.
Topics: Acetaminophen; Animals; Drug Evaluation, Preclinical; Drug Industry; Drug Information Services; Huma | 1980 |
Liaison with industry in the provision of essential information for the management of poisoning.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Drug I | 1980 |
Self-poisoning with drugs: a 3 1/2-year study in Newcastle, NSW.
Topics: Acetaminophen; Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Australia; Barbiturates; B | 1981 |
Treatment of paracetamol poisoning in a cat.
Topics: Acetaminophen; Acetylcysteine; Animals; Cat Diseases; Cats; Poisoning | 1981 |
Contraindications for activated charcoal use.
Topics: Acetaminophen; Adsorption; Animals; Charcoal; Humans; Poisoning; Rats | 1980 |
The laboratory in the diagnosis and management of acetaminophen and salicylate intoxications.
Topics: Acetaminophen; Acetylcysteine; Acid-Base Imbalance; Aspirin; Child, Preschool; Female; Hepatic Encep | 1980 |
[Paracetamol poisoning].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Poisoning | 1995 |
[Paracetamol poisoning].
Topics: Acetaminophen; Humans; Poisoning; Prognosis | 1995 |
[Deaths due to paracetamol poisoning in Denmark 1979-1992].
Topics: Acetaminophen; Cause of Death; Denmark; Drug Utilization; Humans; Poisoning; Suicide | 1995 |
[Paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Denmark; Female; Humans; Kidney; Liver; Male; Poisoning | 1995 |
[Paracetamol poisoning at a department of hepatology].
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Denmark; Female; Hep | 1995 |
Paracetamol and self poisoning.
Topics: Acetaminophen; England; Humans; Poisoning; Suicide; Wales | 1995 |
Controversial issues.
Topics: Acetaminophen; Carbon Monoxide Poisoning; Child, Preschool; Female; Humans; Infant; Poisoning | 1995 |
The clinical value of screening for paracetamol in patients with acute poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Female; Hong Kong; Humans; Longitudinal S | 1995 |
The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction.
Topics: Acetaminophen; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Human | 1995 |
Subtleties of managing acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Child, Preschool; Drug Overdose; Humans; Infant; Ipecac; Po | 1994 |
Correlation of drug pharmacokinetics and effectiveness of multiple-dose activated charcoal therapy.
Topics: Acetaminophen; Animals; Charcoal; Digoxin; Disease Models, Animal; Drug Administration Schedule; Fem | 1995 |
[Severe acute paracetamol and salicylate poisoning. Diagnosis, treatment].
Topics: Acetaminophen; Acute Disease; Adult; Age Factors; Aged; Child; Humans; Infant; Poisoning; Prognosis; | 1994 |
Paracetamol and children.
Topics: Acetaminophen; Child, Preschool; Chronic Disease; Humans; Infant; Poisoning | 1994 |
A new loading dose for N-acetylcysteine? The answer is no.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Drug Interactions; Drug Therapy, Combination; Humans; Poiso | 1994 |
Influence of time until emesis on the efficacy of decontamination using acetaminophen as a marker in a pediatric population.
Topics: Acetaminophen; Biomarkers; Body Burden; Charcoal; Child; Child, Preschool; Databases, Factual; Decon | 1993 |
Severe acetaminophen poisoning with favorable outcome after medical treatment: report of 2 cases.
Topics: Acetaminophen; Acetylcysteine; Adult; Charcoal; Chemical and Drug Induced Liver Injury; Combined Mod | 1993 |
Chronic paracetamol poisoning in children: a warning to health professionals.
Topics: Acetaminophen; Blood Coagulation Disorders; Chronic Disease; Diarrhea; Drug Overdose; Health Occupat | 1994 |
Paracetamol cardiotoxicity.
Topics: Acetaminophen; Acetylcysteine; Humans; Poisoning | 1993 |
Are activated charcoal-N-acetylcysteine interactions of clinical significance?
Topics: Absorption; Acetaminophen; Acetylcysteine; Charcoal; Drug Interactions; Drug Therapy, Combination; H | 1993 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Cause of Death; Drug Overdose; Humans; Poisoning; Suicide | 1993 |
Acetaminophen hepatotoxicity after a prolonged ingestion.
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function Te | 1993 |
[Paracetamol poisoning in infancy].
Topics: Acetaminophen; Dose-Response Relationship, Drug; Exchange Transfusion, Whole Blood; Female; Fetal Al | 1993 |
Comparison of N-acetylcysteine and methylene blue, alone or in combination, for treatment of acetaminophen toxicosis in cats.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Cat Diseases; Cats; Drug Therapy, Combination; Fe | 1995 |
Serial measurements of serum Gc-globulin in acetaminophen intoxication.
Topics: Acetaminophen; Actins; Adult; Analgesics, Non-Narcotic; Case-Control Studies; Female; Hepatic Enceph | 1995 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Drug Administration Schedule; Humans; Liver Failure; Poisoning | 1996 |
[Paracetamol poisoning--case report].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Infant; Poisoning | 1995 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Alcohol Drinking; Fasting; Female; Humans; Liver Failure, Acute; Poisoning; Ri | 1996 |
Outpatient N-acetylcysteine treatment for acetaminophen poisoning: an ethical dilemma or a new financial mandate?
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Ambulatory Care; Analgesics, Non-Narcotic; Female; | 1996 |
Acetaminophen toxicity in children: diagnostic confirmation using a specific antigenic biomarker.
Topics: Acetaminophen; Antigens; Biomarkers; Blood Proteins; Child; Child, Preschool; Enzyme-Linked Immunoso | 1996 |
Acetaminophen and salicylate serum levels in patients with suicidal ingestion or altered mental status.
Topics: Acetaminophen; Acid-Base Equilibrium; Adult; Aged; Analgesics, Non-Narcotic; Cognition Disorders; Dr | 1996 |
Presentation of poisoned patients to accident and emergency departments in the north of England.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Analgesics, Non-Narcotic; Benzodiazepines; Child; Eme | 1996 |
Hospitalisation for deliberate self-poisoning in Scotland from 1981 to 1993: trends in rates and types of drugs used.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Cross-Sectional Studies; Drug Overdose; Female; Hum | 1996 |
Paracetamol overdose.
Topics: Acetaminophen; Drug Overdose; Gastric Lavage; Humans; Poisoning | 1996 |
Safety packaging of acetaminophen combination preparations and severity of adult poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Drug Overdose; Drug Packaging; Female; Hu | 1996 |
The epidemiology of acetaminophen (paracetamol) poisoning in Hong Kong.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Cohort Studies; Female; | 1996 |
[Gc-globulin in paracetamol poisoning].
Topics: Acetaminophen; Adult; Analgesics; Female; Globulins; Hepatic Encephalopathy; Humans; Male; Poisoning | 1996 |
Protective effects of diallyl sulfide on acetaminophen-induced toxicities.
Topics: Acetaminophen; Allyl Compounds; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anticarcino | 1996 |
Changing patterns of self-poisoning in a UK health district.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Drug Overdose; Eth | 1996 |
Adverse reactions to N-acetylcysteine in Inuit to paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Greenland; Hu | 1996 |
[Acute paracetamol and aspirin poisoning].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asp | 1997 |
Angioedema with oral N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Angioedema; Antidotes; Humans; Male; Poisoning | 1997 |
Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Biological Transport; Chromatography, High | 1997 |
Paracetamol poisoning in the north east of England: presentation, early management and outcome.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Charcoal; Child; Englan | 1997 |
Acetaminophen toxicity in an urban county hospital.
Topics: Accidents; Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholism; Chemical and Drug | 1997 |
Oral N-acetylcysteine given intravenously for acetaminophen overdose: we shouldn't have to, but we must.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Free Radical Scavengers; Hum | 1998 |
The risk factors of death from the acetaminophen poisoning with antipyretic-analgesic drugs in Japan.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Disseminated In | 1997 |
The impact of nationally distributed guidelines on the management of paracetamol poisoning in accident and emergency departments. National Poison Information Service.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Emergency Service, Hospital; England; Humans; Poisoning; Pr | 1998 |
Overdose among youth in Bahrain: psycho-social characteristics, contact with helping agencies and problems.
Topics: Acetaminophen; Adjustment Disorders; Adolescent; Adult; Analgesics, Non-Narcotic; Attitude to Health | 1997 |
Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Acute Renal Failure Investigation Team.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Anuria; Case-Control Studies; Child; Child, Preschoo | 1998 |
The Haitian diethylene glycol poisoning tragedy: a dark wood revisited.
Topics: Acetaminophen; Disease Outbreaks; Drug Contamination; Ethylene Glycols; Haiti; Humans; Poisoning | 1998 |
The epidemiology of deliberate self poisoning presenting to Christchurch Hospital Emergency Department.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Child; Emergencies | 1998 |
Paediatric exploratory ingestions of paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Female; Humans; Infant; Male; Poisoning; | 1998 |
[Additional comments on the toxicity of paracetamol (acetaminophen)].
Topics: Acetaminophen; Antidotes; Humans; Injections, Intravenous; Poisoning | 1998 |
Drugs detected in patients suspected of acute intoxication.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholic Intoxication; Am | 1997 |
Combined antipyretic therapy: another potential source of chronic acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Chronic Disease; Drug Interactions; Drug Therapy, Co | 1998 |
The prevalence of dextropropoxyphene in autopsy blood samples.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Analgesics, Opioid; Aut | 1998 |
Effects of a drug overdose in a television drama on presentations to hospital for self poisoning: time series and questionnaire study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Confiden | 1999 |
Effects of a drug overdose in a television drama on knowledge of specific dangers of self poisoning: population based surveys.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Awareness; Drama; Drug Overdose; Female; Health Surveys; Hu | 1999 |
The Tylenol scare: the death of seven people who took the drug triggers a nationwide alert--and a hunt for a madman.
Topics: Acetaminophen; Chicago; Cyanides; Drug and Narcotic Control; Humans; Nonprescription Drugs; Poisonin | 1982 |
An adolescent case of sulfhemoglobinemia associated with high-dose metoclopramide and N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antiemetics; Female; Humans; Metoclopramide; Poisoning; S | 1999 |
[No N-acetylcysteine in the absence of verified paracetamol intoxication].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Chemical and Drug I | 1999 |
Predictive properties of a qualitative urine acetaminophen screen in patients with self-poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Drug Overdose; False Positive Reactions; Female; Humans; Mal | 1999 |
Effects of drug overdose in television drama on presentations for self poisoning. A casual association cannot yet be inferred.
Topics: Acetaminophen; Drama; Humans; Poisoning; Polyethylene Glycols; Scotland; Television | 1999 |
Prevention of paracetamol poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Packaging; Female; Humans; Incidence; Male; Poisoning; | 2000 |
Reduction in incidence of severe paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2000 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Activated charcoal in paracetamol overdose.
Topics: Acetaminophen; Charcoal; Drug Overdose; Evidence-Based Medicine; Humans; MEDLINE; Poisoning | 2000 |
Improvements in the packaging of drugs and chemicals may reduce the likelihood of severe intentional poisonings in adults.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Carbamazepine; Drug Packaging; Household Products; H | 2000 |
Acetaminophen hepatoxicity.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Child; Child, Preschool; Drug Overdose; Fema | 2000 |
Index of suspicion. Case 3. Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Femal | 1999 |
Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; | 2001 |
Paracetamol (acetaminophen) poisoning: report of two cases.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Charcoal; Dru | 2000 |
Determination of paracetamol (acetaminophen) in different body fluids and organ samples after solid-phase extraction using HPLC and an immunological method.
Topics: Acetaminophen; Body Fluids; Brain Chemistry; Chromatography, High Pressure Liquid; Humans; Indicator | 2000 |
Severity of overdose after restriction of paracetamol availability. Why hasn't strategy for minimising paracetamol poisoning been enacted?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Humans; Methioni | 2001 |
Substances used in deliberate self-poisoning 1985-1997: trends and associations with age, gender, repetition and suicide intent.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Analgesics, Non-Narcotic; Antidepressive Agents; | 2001 |
Do poison center triage guidelines affect healthcare facility referrals?
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Dietary Supplements; Guidelines as Topic; Humans; Ir | 2001 |
Effects of legislation restricting pack sizes of paracetamol on self poisoning. Authors did not look at effects on all deliberate and accidental self poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Packaging; Humans; Legislation, Drug; Poisoning; Unite | 2001 |
[Cases of acute poisoning admitted to a medical intensive care unit].
Topics: Accidents; Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Antidepressive Agents; Ant | 2001 |
Limiting the use of gastrointestinal decontamination does not worsen the outcome from deliberate self-poisoning.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Antidepressive Agents; | 2001 |
Random and systematic medication errors in routine clinical practice: a multicentre study of infusions, using acetylcysteine as an example.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Free Radi | 2001 |
[Antipyretic poisoning].
Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2002 |
Advances, challenges, and controversies in poisoning.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Emergency Medical Services; Humans; Poisonin | 2002 |
Troublesome toxins.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Carbon Monoxide Poisoning; Emergency Medical Services; Gast | 2002 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Vomiting in paracetamol overdose.
Topics: Acetaminophen; Adult; Drug Overdose; Evidence-Based Medicine; Female; Humans; Male; Poisoning; Vomit | 2002 |
Treatment strategies for early presenting acetaminophen overdose: a survey of medical directors of poison centers in North America and Europe.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Data Collection; Drug Overdose; Europe; Humans; North Ameri | 2002 |
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; | 1976 |
Letter: Paracetamol test kit.
Topics: Acetaminophen; Humans; Methods; Poisoning | 1976 |
Fatal dextropropoxyphene poisoning in Northern Ireland. Review of 30 cases.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chromatography, Gas; Cyclizine; Death, Sudden; Dextropropoxy | 1977 |
Child-resistant packaging and accidental child poisoning.
Topics: Accident Prevention; Accidents, Home; Acetaminophen; Antidepressive Agents, Tricyclic; Aspirin; Benz | 1977 |
Preventing hepatotoxicity in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Chemical and Drug Induced Liver Injury; Diuretics; Glutathi | 1979 |
Poisonings--an update.
Topics: Accidents; Acetaminophen; Child, Preschool; Humans; Poisoning; Suicide; United States | 1979 |
Changing pattern of drugs used for self-poisoning.
Topics: Acetaminophen; Antidepressive Agents, Tricyclic; Barbiturates; Benzodiazepines; Humans; Hypotension; | 1978 |
The treatment of paracetamol overdose with charcoal haemoperfusion and cysteamine.
Topics: Acetaminophen; Charcoal; Cysteamine; Female; Hemoperfusion; Humans; Middle Aged; Poisoning | 1978 |
The treatment of poisoning.
Topics: Acetaminophen; Acids; Antidotes; Aspirin; Barbiturates; Carbon Tetrachloride Poisoning; Child; Child | 1978 |
Drug analysis in the overdosed patient: its application to clinical toxicology.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Antidepressive Agents, Tricyclic; Child; Child, Presch | 1977 |
Acetaminophen (paracetamol) poisoning: gastrointestinal side effects of cysteamine and their possible cause and treatment.
Topics: Acetaminophen; Antidotes; Cysteamine; Humans; Poisoning | 1977 |
The immediate care of cases of poisoning.
Topics: Acetaminophen; Acute Disease; Critical Care; Diuresis; Humans; Information Services; Paraquat; Poiso | 1977 |
Acute poisoning: an update.
Topics: Acetaminophen; Alkalies; Antidotes; Charcoal; Humans; Parasympatholytics; Physostigmine; Poisoning | 1977 |
[Hemoperfusion with coated activated charcoal for treating acute poisoning by remedies, plant protectants, and fungi. I. Remedies (author's transl)].
Topics: Acetaminophen; Acute Disease; Antidepressive Agents, Tricyclic; Aspirin; Barbiturates; Charcoal; Glu | 1976 |
[Paracetamol poisoning].
Topics: Acetaminophen; Administration, Oral; Adult; Cysteamine; Female; Humans; Injections, Intravenous; Leg | 1976 |
[Letter: Methionine treatment].
Topics: Acetaminophen; Animals; Guinea Pigs; Humans; Methionine; Poisoning; Rabbits; Rats | 1976 |
Fatal drug overdosage.
Topics: Acetaminophen; Adult; Aged; Aspirin; Female; Humans; London; Male; Middle Aged; Poisoning | 1976 |
Packaging: can it help to reduce the incidence of poisoning?
Topics: Acetaminophen; Drug Labeling; Drug Packaging; Humans; Poisoning; Suicide Prevention | 1976 |
Acute paracetamol poisoning.
Topics: Acetaminophen; Humans; Poisoning | 1975 |
The safety assessment in the dog of a charcoal haemoperfusion column.
Topics: Acetaminophen; Animals; Carbon; Charcoal; Chromatography, Gas; Dogs; Pentobarbital; Poisoning; Renal | 1976 |
Letter: Treatment of paracetamol poisoning.
Topics: Acetaminophen; Cysteamine; Humans; Poisoning | 1975 |
Acetaminophen poisoning and toxicity.
Topics: Acetaminophen; Agranulocytosis; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Hypoglyc | 1975 |
Experimental drug intoxication: treatment with charcoal haemoperfusion.
Topics: Acetaminophen; Alcoholic Intoxication; Animals; Aspirin; Barbiturates; Biocompatible Materials; Char | 1975 |
Studies with activated charcoal in the treatment of drug overdosage using the pig as an animal model.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Amobarbital; Animals; Charcoal; Disease Models, | 1975 |
Paracetamol overdose.
Topics: Acetaminophen; Humans; Poisoning | 1976 |
Diethylene glycol poisoning in Nigerian children.
Topics: Acetaminophen; Acute Kidney Injury; Drug Contamination; Ethylene Glycols; Female; Humans; Infant; Ma | 1992 |
Ondansetron to prevent emesis following N-acetylcysteine for acetaminophen intoxication.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Female; Humans; Infusions, Intravenous; Ipecac; Ondansetr | 1992 |
Distinction made between toxicoses caused by acetaminophen and nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cat Diseases; Cats; Dog Diseases; D | 1992 |
The fatal paracetamol dosage--how low can you go?
Topics: Acetaminophen; Adolescent; Brain; Female; Hepatic Encephalopathy; Humans; Liver; Poisoning | 1992 |
Nonsteroidal anti-inflammatory drug toxicosis in dogs and cats: 240 cases (1989-1990)
Topics: Accidents; Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cat Diseases; C | 1992 |
Mechanized toxicological serum tests in screening hospitalized patients.
Topics: Acetaminophen; Alcoholic Intoxication; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Autoan | 1991 |
Gastric decontamination in the poisoned patient.
Topics: Acetaminophen; Adolescent; Aspirin; Charcoal; Child, Preschool; Emergencies; Female; Gastric Lavage; | 1991 |
Acute ethanol administration reduces the antidote effect of N-acetylcysteine after acetaminophen overdose in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Drug Administration Schedule; Drug Interactions; Ethanol; Ma | 1991 |
When does acetaminophen poisoning require treatment?
Topics: Acetaminophen; Humans; Liver; Poisoning | 1991 |
[Risk of poisoning in subacute therapeutic overdosage of paracetamol].
Topics: Acetaminophen; Acute Disease; Dose-Response Relationship, Drug; Drug Information Services; Humans; I | 1991 |
Management of paracetamol poisoning complicated by enzyme induction due to alcohol or drugs.
Topics: Acetaminophen; Adolescent; Adult; Alcohol Drinking; Aspartate Aminotransferases; Humans; Liver; Male | 1990 |
Carbidopa-levodopa overdose.
Topics: Acetaminophen; Carbidopa; Carisoprodol; Female; Humans; Hydrocodone; Ibuprofen; Levodopa; Middle Age | 1991 |
[Severe acute poisoning by barbiturates, tranquilizing agents, tricyclic agents, paracetamol, salicylates].
Topics: Acetaminophen; Acute Disease; Antidepressive Agents, Tricyclic; Barbiturates; Humans; Poisoning; Sal | 1991 |
Parasuicide in central London 1984-1988.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Aspirin; Benzodiazep | 1989 |
Parental administration of chemical agents: a cause of apparent life-threatening events.
Topics: Acetaminophen; Apnea; Cyanosis; Female; Humans; Infant; Infant, Newborn; Male; Methadone; Parents; P | 1989 |
Toxidromes.
Topics: Acetaminophen; Alkalies; Amphetamines; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Carbo | 1985 |
Overdoses.
Topics: Acetaminophen; Acetylcysteine; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cathartics; C | 1985 |
Trends in self-poisoning with drugs in Newcastle, New South Wales, 1980-1982.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Ag | 1986 |
Effect of hyperoxia on liver necrosis induced by hepatotoxins.
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cric | 1986 |
Ipecac-induced emesis and reduction of plasma concentrations of drugs following accidental overdose in children.
Topics: Accidents, Home; Acetaminophen; Child, Preschool; Drug Evaluation; Female; Humans; Ipecac; Male; Pha | 1987 |
Multi-wavelength analyses of second-derivative spectra for rapid determination of acetaminophen in serum.
Topics: Acetaminophen; Colorimetry; Humans; Poisoning; Quality Control; Spectrophotometry | 1988 |
[Poisoning in childhood].
Topics: Acetaminophen; Child; Humans; Lead Poisoning; Loperamide; Mexico; Poisoning | 1987 |
Poison queries received during 1985 by the Regional Drug and Poison Information Centre, Durban.
Topics: Acetaminophen; Benzodiazepines; Child, Preschool; Drug Information Services; Household Products; Hum | 1987 |
The role of the laboratory in acute poisoning: case histories.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Amitriptyline; Ethylene Glycols; Female; Hemoperfus | 1986 |
[Use of spectral methods in the study of poisoning].
Topics: Acetaminophen; Humans; Methaqualone; Poisoning; Spectrophotometry, Infrared; Spectrophotometry, Ultr | 1986 |
Brown urine--a clue to phenacetin intoxication.
Topics: Acetaminophen; Chromatography, Thin Layer; Color; Humans; Phenacetin; Poisoning | 1970 |
Haemodialysis in paracetamol self-poisoning.
Topics: Acetaminophen; Adult; Autoanalysis; Chemical and Drug Induced Liver Injury; Female; Half-Life; Human | 1972 |
Haemodialysis in paracetamol self-poisoning.
Topics: Acetaminophen; Humans; Methods; Poisoning; Renal Dialysis | 1972 |
Haemodialysis in paracetamol self-poisoning.
Topics: Acetaminophen; Humans; Plasma; Poisoning; Renal Dialysis | 1972 |
Haemodialysis in paracetomol self-poisoning.
Topics: Acetaminophen; Humans; Poisoning; Renal Dialysis; Suicide | 1972 |
Blood-glucose in paracetamol poisoning.
Topics: Acetaminophen; Blood Glucose; Humans; Methods; Poisoning | 1973 |
Letter: Treatment of acute paracetamol poisoning.
Topics: Acetaminophen; Alprenolol; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationsh | 1973 |
Successful treatment of severe paracetamol overdosage with cysteamine.
Topics: Acetaminophen; Adolescent; Adult; Bilirubin; Blood Cell Count; Blood Urea Nitrogen; Chemical and Dru | 1974 |
Letter: Prevention of paracetamol poisoning.
Topics: Acetaminophen; Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Combinations; H | 1974 |
Paracetamol overdose: a plan of management.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Cardiomyopathies; Chemical and Drug Induced Liver Injury; | 1974 |
Hemoperfusion for enhanced drug elimination - a kinetic analysis in paracetamol poisoning.
Topics: Acetaminophen; Animals; Charcoal; Dogs; Female; Infusions, Parenteral; Male; Poisoning; Renal Dialys | 1974 |
[Liver damage following paracetamole poisoning].
Topics: Acetaminophen; Acute Kidney Injury; Animals; Autopsy; Blood Sedimentation; Chemical and Drug Induced | 1972 |
A simple plan for the management of drug overdosage.
Topics: Absorption; Acetaminophen; Antidepressive Agents; Barbiturates; Body Fluids; Charcoal; Coma; Female; | 1974 |
The curative effects of cysteamine, cysteine, and dithiocarb in experimental paracetamol poisoning.
Topics: Acetaminophen; Alcohols; Animals; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Cysteami | 1974 |
Acute acetaminophen poisoning.
Topics: Acetaminophen; Bilirubin; Blood Coagulation Disorders; Cardiomyopathies; Diuresis; Humans; Hypoglyce | 1973 |
Emergency toxicological screening for drugs commonly taken in overdose.
Topics: Acetaminophen; Antidepressive Agents; Barbiturates; Benzazepines; Chloral Hydrate; Chromatography, T | 1973 |
Clinical toxicology. VII. Poisoning by salicylates, paracetamol, tricyclic antidepressants and a miscellany of drugs.
Topics: Acetaminophen; Adult; Amphetamine; Antidepressive Agents; Caustics; Digitalis; Fenfluramine; Humans; | 1973 |
Acetaminophen poisoning.
Topics: Acetaminophen; Adolescent; Catalogs, Drug as Topic; Charcoal; Chemical and Drug Induced Liver Injury | 1973 |
Letter: Drug levels.
Topics: Acetaminophen; Carbon Monoxide Poisoning; Humans; Poisoning; Salicylates | 1973 |
Acute poisoning.
Topics: Acetaminophen; Barbiturates; Humans; Poisoning; Scotland; Substance-Related Disorders; Suicide; Tran | 1974 |
[Dialysis of drugs and poisons. 2].
Topics: Acetaminophen; Aminopyrine; Amitriptyline; Aspirin; Carbamazepine; Chlordiazepoxide; Chlorpromazine; | 1972 |
Hepatic damage from overdose of paracetamol.
Topics: Acetaminophen; Animals; Blood; Charcoal; Chemical and Drug Induced Liver Injury; Heparin; Humans; Po | 1972 |
Acute paracetamol poisoning.
Topics: Acetaminophen; Acidosis; Acute Disease; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and D | 1970 |