acetaminophen has been researched along with Plasmodium falciparum Malaria in 22 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Congo is facing frequent failures of treatment of Plasmodium falciparum malaria with chloroquine (CQ), which is still recommended and used as a first-line drug." | 6.71 | Efficacy of sulfadoxine/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Republic of Congo. ( Ebata-Mongo, S; Kiori, J; Le Bras, J; Louya, F; Malanda, M; Malonga, DA; Mouata, AM; Nsimba, B; Oko-Ossho, J; Yocka, D, 2004) |
| " Eligible children will receive treatment allocation randomization either to standard of care for fever management or to prophylactic, scheduled treatment every 6 hours for 72 hours with dual antipyretic therapies using acetaminophen and ibuprofen." | 5.51 | Aggressive antipyretics in central nervous system malaria: Study protocol of a randomized-controlled trial assessing antipyretic efficacy and parasite clearance effects (Malaria FEVER study). ( Birbeck, GL; Chilombe, MB; Mathews, M; McDermott, MP; Mwenechanya, M; Seydel, KB, 2022) |
| "We have previously shown that both chloroquine and paracetamol (acetaminophen) have antipyretic activity during treatment of acute uncomplicated Plasmodium falciparum malaria in children 1-4 years old." | 3.73 | Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes. ( Björkman, A; Hugosson, E; Montgomery, SM; Premji, Z; Troye-Blomberg, M, 2006) |
| "A randomized, open-label, two-treatment, crossover, pharmacokinetic study of paracetamol dosed orally and intramuscularly was conducted." | 2.82 | Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria. ( Chierakul, W; Chotivanich, K; Dondorp, AM; Newton, PN; Plewes, K; Ruengweerayut, R; Silamut, K; Tarning, J; Teerapong, P; Wattanakul, T; White, NJ, 2016) |
| "Congo is facing frequent failures of treatment of Plasmodium falciparum malaria with chloroquine (CQ), which is still recommended and used as a first-line drug." | 2.71 | Efficacy of sulfadoxine/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Republic of Congo. ( Ebata-Mongo, S; Kiori, J; Le Bras, J; Louya, F; Malanda, M; Malonga, DA; Mouata, AM; Nsimba, B; Oko-Ossho, J; Yocka, D, 2004) |
| "Pentoxifylline (POF) may suppress overproduction of tumor necrosis factor alpha (TNF alpha), which is thought to contribute to complications of human falciparum malaria." | 2.68 | Supportive pentoxifylline in falciparum malaria: no effect on tumor necrosis factor alpha levels or clinical outcome: a prospective, randomized, placebo-controlled study. ( Chiwakata, CB; Dietrich, M; Egbring, R; Gaus, W; Hassemer, M; Hemmer, CJ; Hogel, J; Hort, G; Kern, P; Nawroth, PP; Seitz, R, 1997) |
| "falciparum malaria were treated with intravenous quinine and received either mechanical antipyresis alone (electric fanning, tepid sponging, and cool blankets) or in combination with paracetamol." | 2.68 | Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria. ( Brandts, CH; Graninger, W; Kremsner, PG; Ndjavé, M, 1997) |
| "Indomethacin was significantly quicker at clearing fever than acetaminophen (P < 0." | 2.67 | Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria. ( Looareesuwan, S; Wilairatana, P, 1994) |
| "Chloroquine effectiveness was associated with age and ethnicity." | 1.32 | Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso. ( Kouyate, B; Mueller, O; Razum, O; Traore, C, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Chilombe, MB | 1 |
| McDermott, MP | 1 |
| Seydel, KB | 1 |
| Mathews, M | 1 |
| Mwenechanya, M | 1 |
| Birbeck, GL | 1 |
| Paasi, G | 1 |
| Okalebo, CB | 1 |
| Ongodia, P | 1 |
| Namayanja, C | 1 |
| Eregu, EEI | 1 |
| Abongo, G | 1 |
| Olupot, M | 1 |
| Amorut, D | 1 |
| Muhindo, R | 1 |
| Okiror, W | 1 |
| Ndila, C | 1 |
| Olupot-Olupot, P | 1 |
| Plewes, K | 3 |
| Turner, GDH | 2 |
| Dondorp, AM | 3 |
| Kingston, HWF | 1 |
| Ghose, A | 1 |
| Wattanakul, T | 2 |
| Hassan, MMU | 1 |
| Haider, MS | 1 |
| Dutta, PK | 1 |
| Islam, MA | 1 |
| Alam, S | 1 |
| Jahangir, SM | 1 |
| Zahed, ASM | 1 |
| Sattar, MA | 1 |
| Chowdhury, MAH | 1 |
| Herdman, MT | 1 |
| Leopold, SJ | 1 |
| Ishioka, H | 1 |
| Piera, KA | 1 |
| Charunwatthana, P | 1 |
| Silamut, K | 2 |
| Yeo, TW | 1 |
| Lee, SJ | 1 |
| Mukaka, M | 1 |
| Maude, RJ | 1 |
| Faiz, MA | 1 |
| Tarning, J | 2 |
| Oates, JA | 1 |
| Anstey, NM | 1 |
| White, NJ | 2 |
| Day, NPJ | 1 |
| Hossain, MA | 1 |
| Roberts Ii, LJ | 1 |
| Teerapong, P | 1 |
| Newton, PN | 1 |
| Chierakul, W | 1 |
| Chotivanich, K | 1 |
| Ruengweerayut, R | 1 |
| Kofoed, PE | 1 |
| Ursing, J | 1 |
| Rodrigues, A | 1 |
| Rombo, L | 2 |
| Hugosson, E | 2 |
| Tarimo, D | 1 |
| Troye-Blomberg, M | 2 |
| Montgomery, SM | 2 |
| Premji, Z | 2 |
| Björkman, A | 2 |
| Nsimba, B | 1 |
| Malonga, DA | 1 |
| Mouata, AM | 1 |
| Louya, F | 1 |
| Kiori, J | 1 |
| Malanda, M | 1 |
| Yocka, D | 1 |
| Oko-Ossho, J | 1 |
| Ebata-Mongo, S | 1 |
| Le Bras, J | 1 |
| Perch, M | 1 |
| Kofoed, P | 1 |
| Fischer, TK | 1 |
| Có, F | 1 |
| Aaby, P | 1 |
| Eugen-Olsen, J | 1 |
| Mueller, O | 1 |
| Razum, O | 1 |
| Traore, C | 1 |
| Kouyate, B | 1 |
| Ismail, S | 1 |
| Na Bangchang, K | 1 |
| Karbwang, J | 1 |
| Back, DJ | 1 |
| Edwards, G | 1 |
| Wilairatana, P | 2 |
| Looareesuwan, S | 2 |
| Kaojarern, S | 1 |
| Vanijanonta, S | 1 |
| Charoenlarp, P | 1 |
| Berclaz, PY | 1 |
| Benedek, C | 1 |
| Jequier, E | 1 |
| Schutz, Y | 1 |
| Hemmer, CJ | 1 |
| Hort, G | 1 |
| Chiwakata, CB | 1 |
| Seitz, R | 1 |
| Egbring, R | 1 |
| Gaus, W | 1 |
| Hogel, J | 1 |
| Hassemer, M | 1 |
| Nawroth, PP | 1 |
| Kern, P | 1 |
| Dietrich, M | 1 |
| Brandts, CH | 1 |
| Ndjavé, M | 1 |
| Graninger, W | 1 |
| Kremsner, PG | 1 |
| Kazembe, PN | 1 |
| Anderson, BJ | 1 |
| Monteleone, J | 1 |
| Holford, NH | 1 |
| Robert, V | 1 |
| Awono-Ambene, HP | 1 |
| Le Hesran, JY | 1 |
| Trape, JF | 1 |
| Yeboah-Antwi, K | 1 |
| Gyapong, JO | 1 |
| Asare, IK | 1 |
| Barnish, G | 1 |
| Evans, DB | 1 |
| Adjei, S | 1 |
| Tarimo, DS | 1 |
| Minjas, JN | 1 |
| Bygbjerg, IC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819] | 256 participants (Anticipated) | Observational | 2021-01-02 | Enrolling by invitation | |||
| Paracetamol Effect on Oxidative Stress and Renal Function in Severe Falciparum Malaria With Intravascular Haemolysis: A Randomised Controlled Clinical Trial[NCT01641289] | 62 participants (Actual) | Interventional | 2012-07-10 | Completed | |||
| The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau[NCT00137566] | Phase 4 | 0 participants | Interventional | 2004-05-31 | Active, not recruiting | ||
| Randomised, Double-Blind, Placebo Controlled Study of the Antipyretic Effect of Ibuprofen in Children With Uncomplicated Malaria[NCT00167713] | Phase 4 | 50 participants | Interventional | 2003-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for acetaminophen and Plasmodium falciparum Malaria
| Article | Year |
|---|---|
Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Coma; De | 2018 |
13 trials available for acetaminophen and Plasmodium falciparum Malaria
| Article | Year |
|---|---|
Aggressive antipyretics in central nervous system malaria: Study protocol of a randomized-controlled trial assessing antipyretic efficacy and parasite clearance effects (Malaria FEVER study).
Topics: Acetaminophen; Animals; Antipyretics; Central Nervous System; Child; Fever; Histidine; Humans; Ibupr | 2022 |
PARIST study protocol: a phase I/II randomised, controlled clinical trial to assess the feasibility, safety and effectiveness of paracetamol in resolving acute kidney injury in children with severe malaria.
Topics: Acetaminophen; Acute Kidney Injury; Child; Clinical Trials, Phase I as Topic; Clinical Trials, Phase | 2023 |
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area | 2018 |
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area | 2018 |
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area | 2018 |
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area | 2018 |
Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Antimalarials; Antipyretics; Biological Avai | 2016 |
Paracetamol versus placebo in treatment of non-severe malaria in children in Guinea-Bissau: a randomized controlled trial.
Topics: Acetaminophen; Adolescent; Antipyretics; Body Temperature; Child; Child, Preschool; Female; Fever; G | 2011 |
Antipyretic, parasitologic, and immunologic effects of combining sulfadoxine/pyrimethamine with chloroquine or paracetamol for treating uncomplicated Plasmodium falciparum malaria.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antimalarials; Body Temperature; Child, Preschool; | 2003 |
Efficacy of sulfadoxine/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Republic of Congo.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antimalarials; Child, Preschool; Congo; Drug Combinations; | 2004 |
Paracetamol disposition in Thai patients during and after treatment of falciparum malaria.
Topics: Acetaminophen; Adult; Biotransformation; Half-Life; Humans; Malaria, Falciparum; Male | 1995 |
Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Female; Fever; Humans; Indomethacin; Malaria | 1994 |
Supportive pentoxifylline in falciparum malaria: no effect on tumor necrosis factor alpha levels or clinical outcome: a prospective, randomized, placebo-controlled study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Antimalarials; Biopterins; Drug Therapy, Combi | 1997 |
Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Child; Child, Preschool; Female; Fever; Humans; In | 1997 |
Impact of prepackaging antimalarial drugs on cost to patients and compliance with treatment.
Topics: Acetaminophen; Adult; Antimalarials; Child; Chloroquine; Dosage Forms; Drug Costs; Drug Packaging; G | 2001 |
Sulfadoxine-pyrimethamine monotherapy in Tanzanian children gives rapid parasite clearance but slow fever clearance that is improved by chloroquine in combination therapy.
Topics: Acetaminophen; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Dru | 2002 |
8 other studies available for acetaminophen and Plasmodium falciparum Malaria
| Article | Year |
|---|---|
Serum levels of soluble urokinase plasminogen activator receptor is associated with parasitemia in children with acute Plasmodium falciparum malaria infection.
Topics: Acetaminophen; Acute Disease; Amoxicillin; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; | 2004 |
Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antimalarials; Burkina Faso; Caregivers; Child, Preschool; | 2004 |
Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antimalarials; Child, Preschool; Chloroquine; Cyto | 2006 |
Gastric emptying in acute uncomplicated falciparum malaria.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Convalescence; Gastric Emptying; Humans; Intestinal | 1995 |
Changes in protein turnover and resting energy expenditure after treatment of malaria in Gambian children.
Topics: Acetaminophen; Adolescent; Body Mass Index; Body Temperature; Body Weight; Child; Chloroquine; Energ | 1996 |
Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antimalarials; Child; Cross Infection; Ethics, Medical; Hum | 1997 |
Variability of concentrations after rectal paracetamol.
Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Adult; Analgesics, Non-Narcotic; Child; | 1998 |
Gametocytemia and infectivity to mosquitoes of patients with uncomplicated Plasmodium falciparum malaria attacks treated with chloroquine or sulfadoxine plus pyrimethamine.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Animals; Anopheles; Antimalarials; Child | 2000 |