Page last updated: 2024-10-22

acetaminophen and Periodontal Diseases

acetaminophen has been researched along with Periodontal Diseases in 12 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Periodontal Diseases: Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.

Research Excerpts

ExcerptRelevanceReference
"Postoperative pain was assessed during the first 8 hours and on the following day using the 101-point numeric rate scale (NRS-101) and the four-point verbal rating scale (VRS-4)."2.74The efficacy of acetaminophen-caffeine compared to Ibuprofen in the control of postoperative pain after periodontal surgery: a crossover pilot study. ( Rashwan, WA, 2009)
"Flurbiprofen was shown to possess an adequate analgesic effect superior to either placebo (P less than 0."2.67Analgesic efficacy of flurbiprofen as compared to acetaminophen and placebo after periodontal surgery. ( Gallardo, F; Rossi, E, 1990)
"Ibuprofen 400 mg was consistently more effective than aspirin 650 mg, acetaminophen 600 mg, and both aspirin and acetaminophen when combined with codeine 60 mg."1.27Five studies on ibuprofen for postsurgical dental pain. ( Cooper, SA, 1984)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19906 (50.00)18.7374
1990's4 (33.33)18.2507
2000's1 (8.33)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Freudenthal, N1
Sternudd, M1
Jansson, L1
Wannfors, K1
Rashwan, WA1
Cooper, SA2
Wagenberg, B1
Eskow, R1
Zissu, J1
Seymour, RA1
Tucker, PW1
Smith, JR2
Adams, DF2
Reed, KL1
Lie, T1
Guedes, MS1
Rezende, Jda S1
Ventre, B1
Arneberg, P1
Bjertness, E1
Storhaug, K1
Glennås, A1
Bjerkhoel, F1
Gallardo, F1
Rossi, E1
Becker, GL1
Cohen, S1
Borer, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective, Multicenter Study Comparing Healing After Treatment With the Sonendo GentleWave™ System as Compared to a Traditional Root Canal Therapy Literature Control[NCT02285595]69 participants (Actual)Interventional2014-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With a PAI Score of < 3, = 3, or = 4 or 5

"The periapical index: A scoring system for radiographic assessment of apical periodontitis. Score of 1: Normal. Score of 2: Small changes in bone structure. Score of 3: Changes in bone structure with some mineral loss (bone loss). Score of 4: Periodontitis with well-defined radiolucent area (apical periodontitis). Score of 5: Severe Periodontitis with exacerbating features (apical periodontitis).~Healed is defined by absence of a radiographic indication of apical periodontitis (PAI <3) and absence of clinical signs and symptoms other than tenderness to percussion.~Healing is defined by a reduction of radiolucency (if radiolucency is present at Baseline) combined with the absence of clinical signs and symptoms other than tenderness to percussion." (NCT02285595)
Timeframe: 12 months

InterventionParticipants (Count of Participants)
PAI Score < 3PAI Score = 3PAI Score 4 or 5
GentleWave™ Treatment Group5130

Trials

7 trials available for acetaminophen and Periodontal Diseases

ArticleYear
A double-blind randomized study evaluating the effect of intra-alveolar chlorhexidine gel on alveolar osteitis after removal of mandibular third molars.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2015, Volume: 73, Issue:4

    Topics: Acetaminophen; Adult; Aged; Analgesics; Anatomic Variation; Anti-Infective Agents, Local; Chlorhexid

2015
The efficacy of acetaminophen-caffeine compared to Ibuprofen in the control of postoperative pain after periodontal surgery: a crossover pilot study.
    Journal of periodontology, 2009, Volume: 80, Issue:6

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; C

2009
Double-blind evaluation of suprofen and aspirin in the treatment of periodontal pain.
    Pharmacology, 1983, Volume: 27 Suppl 1

    Topics: Acetaminophen; Adult; Aspirin; Clinical Trials as Topic; Codeine; Double-Blind Method; Female; Human

1983
A comparison of 2 analgesic regimens for the control of postoperative periodontal discomfort.
    Journal of periodontology, 1996, Volume: 67, Issue:2

    Topics: Acetaminophen; Administration, Oral; Adult; Alveolectomy; Analgesics, Non-Narcotic; Analgesics, Opio

1996
A pilot study comparing ketoprofen and acetaminophen with hydrocodone for the relief of postoperative periodontal discomfort.
    Anesthesia progress, 1997,Spring, Volume: 44, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Dental; Anti-Inflammatory A

1997
[Clinical study of a new analgesic in dentistry].
    Le Chirurgien-dentiste de France, 1978, Mar-30, Volume: 48, Issue:25

    Topics: Acetaminophen; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Clinical

1978
Analgesic efficacy of flurbiprofen as compared to acetaminophen and placebo after periodontal surgery.
    Journal of periodontology, 1990, Volume: 61, Issue:4

    Topics: Acetaminophen; Adult; Double-Blind Method; Female; Flurbiprofen; Humans; Male; Middle Aged; Pain Mea

1990

Other Studies

5 other studies available for acetaminophen and Periodontal Diseases

ArticleYear
Five studies on ibuprofen for postsurgical dental pain.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Aspirin; Codeine; Drug Combinations; Female; Humans; I

1984
Efficacy of paracetamol in reducing post-operative pain after periodontal surgery.
    Journal of clinical periodontology, 1983, Volume: 10, Issue:3

    Topics: Acetaminophen; Double-Blind Method; Female; Humans; Male; Pain, Postoperative; Periodontal Diseases;

1983
[Clinical evaluation of streptokinase + acetaminophen in dentistry].
    Quintessencia, 1978, Volume: 5, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combi

1978
Remaining teeth, oral dryness and dental health habits in middle-aged Norwegian rheumatoid arthritis patients.
    Community dentistry and oral epidemiology, 1992, Volume: 20, Issue:5

    Topics: Acetaminophen; Adult; Analysis of Variance; Arthritis, Rheumatoid; Codeine; Dental Care; Dental Cari

1992
The sequelae of accidentally injecting sodium hypochlorite beyond the root apex. Report of a case.
    Oral surgery, oral medicine, and oral pathology, 1974, Volume: 38, Issue:4

    Topics: Acetaminophen; Adult; Brompheniramine; Dental Caries; Edema; Female; Humans; Iatrogenic Disease; Ora

1974