acetaminophen has been researched along with Peptic Ulcer in 29 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Peptic Ulcer: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " We evaluated all dispensed prescriptions for either a cyclooxygenase (COX)-2 inhibitor, nonselective nonsteroidal anti-inflammatory drug or acetaminophen written by eligible general practitioners between May 2000 and June 2001 to elderly patients suffering from osteoarthritis." | 5.11 | Impact of a general practitioner educational intervention on osteoarthritis treatment in an elderly population. ( Beaulieu, M; Bessette, L; Choquette, D; Joseph, L; LeLorier, J; Rahme, E; Toubouti, Y, 2005) |
| "To assess the efficacy of cyclooxygenase-2 selective inhibitors (coxibs) in osteoarthritis (OA) and their gastrointestinal, cardiovascular, renovascular, and hepatic side effects compared with traditional nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen." | 4.84 | COX-2 selective inhibitors in the treatment of osteoarthritis. ( Hochberg, M; Laine, L; Rostom, A; White, WB, 2008) |
| "We examined in a controlled study whether psychologic disturbances in men with peptic ulcer disease were related to other potential ulcer "risk factors" (serum pepsinogen concentrations, cigarette smoking, and intake of alcohol, aspirin, or coffee)." | 3.67 | Life events stress and psychosocial factors in men with peptic ulcer disease. II. Relationships with serum pepsinogen concentrations and behavioral risk factors. ( Feldman, M; Luther, J; Samloff, IM; Walker, P, 1988) |
| "Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear." | 3.67 | Peptic ulcer and non-steroidal anti-inflammatory agents. ( Dobson, AJ; Duggan, JM; Fahey, P; Johnson, H, 1986) |
| "A comparison of aspirin and acetaminophen consumption in 346 matched pairs of patients with hematemesis and melena and general population control subjects has shown associations between intake of both drugs and bleeding." | 3.66 | Analgesic intake and the risk of acute upper gastrointestinal bleeding. ( Coggon, D; Langman, MJ; Spiegelhalter, D, 1983) |
| " The risk of ulcer complications can however be reduced, and perhaps completely removed, by using the lowest dose of the least toxic member of the class." | 2.42 | Adverse effects of conventional non-steroidal anti-inflammatory drugs on the upper gastrointestinal tract. ( Langman, MJ, 2003) |
| " Some of the newer NSAIDs seem at normal dosage to be far less damaging than traditional ASA or indomethacin." | 2.37 | Gastroduodenal damage due to drugs, alcohol and smoking. ( Domschke, S; Domschke, W, 1984) |
| "Aspirin alone was the least frequently ingested." | 1.26 | Analgesic ingestion and chronic peptic ulcer. ( Ariotti, DE; Fenton, BH; MacLennan, R; McIntosh, JH; Piper, DW, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (55.17) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 7 (24.14) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pellicano, R | 1 |
| Loke, YK | 1 |
| Galunska, B | 1 |
| Marazova, K | 1 |
| Tankova, T | 1 |
| Popov, A | 1 |
| Frangov, P | 1 |
| Krushkov, I | 1 |
| Di Massa, A | 1 |
| Langman, MJ | 3 |
| Rahme, E | 1 |
| Choquette, D | 1 |
| Beaulieu, M | 1 |
| Bessette, L | 1 |
| Joseph, L | 1 |
| Toubouti, Y | 1 |
| LeLorier, J | 1 |
| Laine, L | 1 |
| White, WB | 1 |
| Rostom, A | 1 |
| Hochberg, M | 1 |
| Levinson, M | 1 |
| Domschke, S | 1 |
| Domschke, W | 1 |
| Coggon, D | 1 |
| Spiegelhalter, D | 1 |
| Ivey, KJ | 1 |
| Seegers, AJ | 1 |
| Jager, LP | 1 |
| van Noordwijk, J | 1 |
| Piper, DW | 2 |
| McIntosh, JH | 2 |
| Ariotti, DE | 1 |
| Fenton, BH | 1 |
| MacLennan, R | 1 |
| Petersen, KU | 1 |
| Garnett, WR | 1 |
| Dajani, EZ | 1 |
| García Rodríguez, LA | 1 |
| Hernández-Díaz, S | 1 |
| Lewis, JD | 1 |
| Goodman, MJ | 1 |
| Kent, PW | 1 |
| Truelove, SC | 1 |
| Day, R | 1 |
| Seideman, P | 1 |
| Cho, CH | 1 |
| Ogle, CW | 1 |
| Walker, AM | 2 |
| Jick, H | 2 |
| Hernandez Avila, M | 1 |
| Romieu, I | 1 |
| Spiegelman, DL | 1 |
| Perera, DR | 1 |
| Walker, P | 1 |
| Luther, J | 1 |
| Samloff, IM | 1 |
| Feldman, M | 1 |
| Duggan, JM | 1 |
| Dobson, AJ | 1 |
| Johnson, H | 1 |
| Fahey, P | 1 |
| Wright, RC | 1 |
| Huskisson, EC | 1 |
| Hart, FD | 1 |
| Shenfield, GM | 1 |
| Taylor, RT | 1 |
6 reviews available for acetaminophen and Peptic Ulcer
| Article | Year |
|---|---|
Gastrointestinal damage by non-steroidal anti-inflammatory drugs: updated clinical considerations.
Topics: Acetaminophen; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cyclooxygenase 2 | 2014 |
Adverse effects of conventional non-steroidal anti-inflammatory drugs on the upper gastrointestinal tract.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Drug Inte | 2003 |
COX-2 selective inhibitors in the treatment of osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cycl | 2008 |
Gastroduodenal damage due to drugs, alcohol and smoking.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Ethanol; Gastric Mucosa; Gastrointestinal | 1984 |
[Omeprazole and the cytochrome P450 system of the liver].
Topics: Acetaminophen; Carcinogenicity Tests; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; C | 1993 |
Ibuprofen. A review.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials | 1971 |
2 trials available for acetaminophen and Peptic Ulcer
| Article | Year |
|---|---|
Impact of a general practitioner educational intervention on osteoarthritis treatment in an elderly population.
Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; | 2005 |
Ibuprofen. A review.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials | 1971 |
22 other studies available for acetaminophen and Peptic Ulcer
| Article | Year |
|---|---|
Aspirin or paracetamol - what's good for you?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical | 2009 |
Effects of paracetamol and propacetamol on gastric mucosal damage and gastric lipid peroxidation caused by acetylsalicylic acid (ASA) in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dino | 2002 |
Ulcer, back pain, and jaundice in an alcoholic.
Topics: Acetaminophen; Adult; Alcoholism; Back Pain; Chemical and Drug Induced Liver Injury; Dextropropoxyph | 1983 |
Analgesic intake and the risk of acute upper gastrointestinal bleeding.
Topics: Acetaminophen; Analgesics; Aspirin; Female; Gastrointestinal Hemorrhage; Hematemesis; Humans; Male; | 1983 |
Drugs, gastritis, and peptic ulcer.
Topics: Acetaminophen; Animals; Aspirin; Bicarbonates; Cimetidine; Duodenitis; Gastric Acid; Gastric Mucosa; | 1981 |
An hypothesis concerning the protective action of paracetamol against the erosive activity of acetylsalicylic acid in the rat stomach.
Topics: Acetaminophen; Animals; Aspirin; Disease Models, Animal; Gastric Mucosa; Male; Peptic Ulcer; Rats | 1980 |
Analgesic ingestion and chronic peptic ulcer.
Topics: Acetaminophen; Analgesics; Aspirin; Australia; Duodenal Ulcer; Female; Humans; Male; Peptic Ulcer; R | 1981 |
GI effects of OTC analgesics: implications for product selection.
Topics: Acetaminophen; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Dyspepsia; Gastrointestinal Hem | 1996 |
Gastrointestinal toxicity of over-the-counter analgesics.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg | 1998 |
Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Case- | 2001 |
Will the safest analgesic please stand up.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Peptic Ul | 2002 |
Inhibition of glucosamine synthesis by salicylates, hydrocortisone and two non-ulcerogenic drugs.
Topics: Acetaminophen; Aspirin; Carbohydrate Epimerases; Duodenal Ulcer; Gastric Mucosa; Gentamicins; Glutam | 1977 |
NSAIDs, musculoskeletal disorders and gastrointestinal adverse effects.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bone Diseases; Gastrointestinal Hemorr | 1991 |
Paracetamol potentiates stress-induced gastric ulceration in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Gastric Mucosa; Injections, Subcutaneous; Male; Mast C | 1990 |
Paracetamol and peptic ulcer.
Topics: Acetaminophen; Humans; Peptic Ulcer | 1989 |
Choice of non-steroidal anti-inflammatory drug in persons treated for dyspepsia.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Antacids; Anti-Inflammatory Agents, Non-Steroida | 1988 |
Paracetamol and peptic ulcer.
Topics: Acetaminophen; Humans; Peptic Ulcer; Statistics as Topic | 1988 |
Life events stress and psychosocial factors in men with peptic ulcer disease. II. Relationships with serum pepsinogen concentrations and behavioral risk factors.
Topics: Acetaminophen; Alcohol Drinking; Aspirin; Behavior; Coffee; Humans; Life Change Events; Male; Pepsin | 1988 |
Anti-inflammatory drug intake and the risk of ulcer complications.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastrointestinal Hemorrhage; | 1986 |
Peptic ulcer and non-steroidal anti-inflammatory agents.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Aspirin; Duodenal Ulcer; Female; Humans; Male; Middle | 1986 |
A simple plan for the management of drug overdosage.
Topics: Absorption; Acetaminophen; Antidepressive Agents; Barbiturates; Body Fluids; Charcoal; Coma; Female; | 1974 |
Aspirin and gastric bleeding.
Topics: Acetaminophen; Aspirin; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer | 1967 |