acetaminophen has been researched along with Parkinson Disease in 16 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " There was a dose-response relationship between tablets of ibuprofen taken per week and PD risk (p trend = 0." | 6.47 | Use of ibuprofen and risk of Parkinson disease. ( Ascherio, A; Chen, H; Gao, X; Schwarzschild, MA, 2011) |
| " There was a dose-response relationship between tablets of ibuprofen taken per week and PD risk (p trend = 0." | 2.47 | Use of ibuprofen and risk of Parkinson disease. ( Ascherio, A; Chen, H; Gao, X; Schwarzschild, MA, 2011) |
| "Nonaspirin NSAID use was associated with a higher risk in women and a lower risk in men." | 1.33 | Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease. ( García Rodríguez, LA; Hernán, MA; Logroscino, G, 2006) |
| "4." | 1.32 | An investigation into the inter-relationships of sulphur xeno-biotransformation pathways in Parkinson's and motor neurone diseases. ( Steventon, GB; Waring, RH; Williams, AC, 2003) |
| "We studied 68 patients with Parkinson's disease (PD) with probe drugs to determine whether a defect in metabolism might be an etiologic factor and found no difference between patients and controls in their ability to form the 4-hydroxy metabolite of debrisoquin." | 1.28 | Xenobiotic metabolism in Parkinson's disease. ( Heafield, MT; Steventon, GB; Waring, RH; Williams, AC, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bohler, S | 1 |
| Liu, X | 1 |
| Krauskopf, J | 1 |
| Caiment, F | 1 |
| Aubrecht, J | 1 |
| Nicolaes, GAF | 1 |
| Kleinjans, JCS | 1 |
| Briedé, JJ | 1 |
| Locke, CJ | 1 |
| Fox, SA | 1 |
| Caldwell, GA | 1 |
| Caldwell, KA | 1 |
| Gao, X | 1 |
| Chen, H | 3 |
| Schwarzschild, MA | 3 |
| Ascherio, A | 3 |
| Zhang, SM | 1 |
| Hernán, MA | 2 |
| Willett, WC | 1 |
| Colditz, GA | 1 |
| Speizer, FE | 1 |
| Steventon, GB | 3 |
| Waring, RH | 3 |
| Williams, AC | 3 |
| Jacobs, E | 1 |
| McCullough, ML | 1 |
| Calle, EE | 1 |
| Thun, MJ | 1 |
| Logroscino, G | 1 |
| García Rodríguez, LA | 1 |
| Meagher, LJ | 1 |
| McKay, D | 1 |
| Herkes, GK | 1 |
| Needham, M | 1 |
| Roos, RA | 1 |
| Steenvoorden, JM | 1 |
| Mulder, GJ | 1 |
| Van Kempen, GM | 1 |
| Hatori, K | 1 |
| Kondo, T | 1 |
| Mizuno, Y | 1 |
| Casper, D | 1 |
| Yaparpalvi, U | 1 |
| Rempel, N | 1 |
| Werner, P | 1 |
| Robertson, DR | 1 |
| Higginson, I | 1 |
| Macklin, BS | 1 |
| Renwick, AG | 1 |
| Waller, DG | 1 |
| George, CF | 1 |
| Heafield, MT | 2 |
| Sturman, S | 1 |
| Green, M | 1 |
| Factor, SA | 1 |
| Weiner, WJ | 1 |
| Hefti, F | 1 |
| Kalow, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Parkinson's, Genes and Environment (PAGE) Study[NCT00367900] | 3,100 participants (Actual) | Observational | 2006-08-21 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for acetaminophen and Parkinson Disease
| Article | Year |
|---|---|
Use of ibuprofen and risk of Parkinson disease.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Confidence Interv | 2011 |
Ethnic differences in reactions to drugs and xenobiotics. Conjugation reactions.
Topics: Acetaminophen; Amobarbital; Asian People; Canada; Catechol O-Methyltransferase; Ethnicity; Female; G | 1986 |
2 trials available for acetaminophen and Parkinson Disease
| Article | Year |
|---|---|
[Levodopa loading test as an early marker of Parkinson's disease].
Topics: Acetaminophen; Aged; Biomarkers; Gastric Emptying; Humans; Intestinal Absorption; Levodopa; Middle A | 1997 |
The influence of protein containing meals on the pharmacokinetics of levodopa in healthy volunteers.
Topics: Acetaminophen; Adult; Dietary Proteins; Gastric Emptying; Humans; Intestinal Absorption; Levodopa; M | 1991 |
12 other studies available for acetaminophen and Parkinson Disease
| Article | Year |
|---|---|
Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease.
Topics: Acetaminophen; Adolescent; Adult; Benzoquinones; Circulating MicroRNA; Crystallography, X-Ray; Cytoc | 2019 |
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease.
Topics: Acetaminophen; Adrenergic Agents; alpha-Synuclein; Analgesics, Non-Narcotic; Animals; Animals, Genet | 2008 |
Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2003 |
An investigation into the inter-relationships of sulphur xeno-biotransformation pathways in Parkinson's and motor neurone diseases.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Biotransformation; Carbocysteine; Erythrocytes; Femal | 2003 |
Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Female; Human | 2005 |
Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents; Aspirin; Case-Co | 2006 |
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy.
Topics: Acetaminophen; Acyclovir; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Ba | 2006 |
Acetaminophen sulfation in patients with Parkinson's disease or Huntington's disease is not impaired.
Topics: Acetaminophen; Adult; Aged; Blood Platelets; Chromatography, High Pressure Liquid; Female; Humans; H | 1993 |
Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro.
Topics: Acetaminophen; Animals; Aspirin; Cell Count; Cells, Cultured; Dopamine; Fetus; Glutamic Acid; Ibupro | 2000 |
Metabolism of low-dose paracetamol in patients with chronic neurological disease.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Ag | 1990 |
Xenobiotic metabolism in Parkinson's disease.
Topics: Acetaminophen; Humans; Parkinson Disease; Reference Values; Sulfates; Sulfoxides; Xenobiotics | 1989 |
Acetaminophen metabolism by cytochrome P450 monooxygenases in Parkinson's disease.
Topics: Acetaminophen; Carbidopa; Cytochrome P-450 Enzyme System; Female; Humans; Levodopa; Male; Middle Age | 1989 |