Page last updated: 2024-10-22

acetaminophen and Osteoarthritis

acetaminophen has been researched along with Osteoarthritis in 228 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

Research Excerpts

ExcerptRelevanceReference
" The following variables were assessed: articular pain and swelling, AUSCAN and COCHIN functional questionnaires, grip and pinch strength, goniometry, perception of improvement, acetaminophen consumption, and simple radiography."9.51Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up. ( Fernandes, ADRC; Furtado, RNV; Machado, FS; Natour, J; Oliveira, HAV; Paschoal, NOS, 2022)
"Insured patients with a history of osteoarthritis or back pain and receiving ibuprofen, other ns-NSAIDs, COX-2i or paracetamol between 1 November, 2019 and 31 January, 2020 (study enrolment window 1) or between 1 February, 2020 and 31 October, 2020 (study enrolment window 2)."9.41Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study. ( Argyriou, G; Brash, JT; Driessen, S; Prieto-Alhambra, D; Reich, C; Seager, S; Turkmen, C; Varrassi, G; Xie, J, 2023)
"The aim of this study was to evaluate the clinical effects of oral glucosamine sulfate, compared with placebo, on osteoarthritis in the temporomandibular joints (TMJs)."9.15No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study. ( Cahlin, BJ; Dahlström, L, 2011)
"To evaluate efficacy and safety of aceclofenac-paracetamol combination against aceclofenac alone in patients with osteoarthritis (OA) flare-up."9.14A randomized, multicentric, comparative evaluation of aceclofenac-paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up. ( Bartakke, G; Chandurkar, N; Desai, M; Kini, S; Pareek, A; Sharma, VD, 2009)
"To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)."9.14Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009)
"To assess the efficacy and safety of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA; MS-sNT), which contain morphine sulfate pellets with a sequestered naltrexone core, in treating patients with chronic, moderate-to-severe osteoarthritis (hip or knee) pain."9.14Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain. ( Hale, M; Katz, N; Morris, D; Stauffer, J, 2010)
"To assess the use of n-of-1 trials for short-term choice of drugs for osteoarthritis, with particular reference to comparing the efficacy of sustained-release [SR] paracetamol with celecoxib in individual patients."9.12Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials. ( Brown, RM; Del Mar, CB; McNairn, N; Nikles, CJ; Schluter, PJ; Yelland, MJ, 2007)
"To examine the efficacy and safety of two doses of long-acting acetaminophen in patients with osteoarthritis (OA) of the hip or knee."9.12Three-month efficacy and safety of acetaminophen extended-release for osteoarthritis pain of the hip or knee: a randomized, double-blind, placebo-controlled study. ( Altman, RD; Schweinle, JE; Temple, AR; Zinsenheim, JR, 2007)
"5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) as add-on therapy for subjects with osteoarthritis (OA) pain inadequately controlled by COX-2 nonsteroidal antiinflammatory drugs (NSAID)."9.11Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. ( Emkey, R; Jordan, D; Kamin, M; Rosenthal, N; Wu, SC, 2004)
"5 mg/acetaminophen (APAP) 325 mg combination tablets (tramadol/APAP) to existing therapy for painful osteoarthritis (OA) flare in a subset of elderly patients."9.11Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population. ( Jordan, D; Kamin, M; Rosenthal, NR; Silverfield, JC; Wu, SC, 2004)
"The addition of tramadol/acetaminophen tablets to existing therapy was compared with the addition of placebo in the treatment of OA flare pain."9.10Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. ( Kamin, M; Rosenthal, N; Silverfield, JC; Wu, SC, 2002)
"To compare the efficacy and safety of controlled release oxycodone given every 12 h around the clock with immediate release oxycodone-acetaminophen (APAP) given 4 times daily for osteoarthritis (OA) pain."9.09Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial. ( Boyd, RE; Caldwell, JR; Hague, JM; Hale, ME; Iwan, T; Lacouture, PG; Shi, M, 1999)
"To assess the clinical efficacy of chondroitin sulfate (CS) in comparison with the nonsteroidal antiinflammatory drug (NSAID) diclofenac sodium (DS) in a medium/longterm clinical study in patients with knee osteoarthritis (OA)."9.08Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. ( Boccanera, L; Bocchi, L; Galati, M; Manopulo, R; Morreale, P; Saponati, G, 1996)
"A multicenter, double-blind, cross-over, random-order study compared the efficacy of floctafenin, 800 mg/day and acetaminophen, 3000 mg/day, in providing pain relief to 192 patients with chronic pain due to osteoarthritis in the lower limbs."9.08Floctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs. Franco-Belgian Task Force. ( du Laurier, MV; Fannius, J; Lequesne, M; Reginster, JY; Verdickt, W, 1997)
"A parallel group study for one month of 392 patients was undertaken to define the optimal dose of nimesulide for the treatment of painful osteoarthritis (OA)."9.07Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis. ( Bourgeois, P; Dreiser, RL; Lequesne, MG; Macciocchi, A; Monti, T, 1994)
"To compare the relative safety and efficacy of naproxen and acetaminophen in the treatment of osteoarthritis (OA) of the knee."9.07Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee. ( Alarcón, GS; Brooks, RH; Clegg, DO; Egger, MJ; Field, EH; Neuner, R; Skosey, JL; Ward, JR; Williams, HJ; Willkens, RF, 1993)
"A double-blind randomized parallel group trial was undertaken to compare the acceptability and efficacy of 2 forms of analgesic treatment, DI-Antalvic (Houde Laboratories, Puteaux, France) (30 mg dextropropoxyphene and 400 mg paracetamol per capsule) and Efferalgan-Codeine (UPSA Laboratories, Rueil Malmaison, France) (30 mg codeine and 500 mg paracetamol per tablet) prescribed for 1 week at doses of 6 capsules/day and 6 tablets/day, respectively, in 141 outpatients with active osteoarthritis of the knee or hip."9.07Acceptability and efficacy of two associations of paracetamol with a central analgesic (dextropropoxyphene or codeine): comparison in osteoarthritis. ( Boissier, C; Decousus, H; Gayet, JL; Hocquart, J; Laporte-Simitsidis, S; Mismetti, P; Perpoint, B; Queneau, P; Rambaud, C, 1992)
"In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day."9.07Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991)
"This randomized, double-blind, multi-centre study was undertaken to evaluate the efficacy and safety of treatment for 4 weeks with codeine plus paracetamol versus paracetamol in relieving chronic pain due to osteoarthritis of the hip."9.06Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study. ( Andersen, HM; Branebjerg, PE; Gjøderum, O; Hvass, I; Kjærsgaard-Andersen, P; Krøner, K; Madsen, F; Nafei, A; Pedersen, L; Skov, O, 1990)
"Twenty-eight patients with osteoarthritis participated in a prospective, double-blind, cross-over study to compare the safety and efficacy of a new combination analgesic containing ibuprofen 200 mg, paracetamol 250 mg and codeine phosphate 10 mg per tablet (Myprodol; Rio Ethicals) with a standard treatment regimen (ibuprofen 200 mg per tablet)."9.06Comparison of a standard ibuprofen treatment regimen with a new ibuprofen/paracetamol/codeine combination in chronic osteo-arthritis. ( van Vuren, JP; Vlok, GJ, 1987)
"The major clinical guidelines recommend the use of acetaminophen (acetyl-para-aminophenol [APAP]) for the treatment of mild-to-moderate symptoms of osteoarthritis (OA) and only recommend the use of nonsteroidal anti-inflammatory drugs (NSAIDs) after APAP failure."8.86The role of acetaminophen in the treatment of osteoarthritis. ( Flood, J, 2010)
"Tramadol is increasingly used for the treatment of osteoarthritis (OA) because it does not produce gastrointestinal bleeding or renal problems and does not affect articular cartilage."8.84Tramadol for osteoarthritis: a systematic review and metaanalysis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2007)
"Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage."8.83Tramadol for osteoarthritis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2006)
"To assess the best available evidence for efficacy of paracetamol (acetaminophen) in the treatment of osteoarthritis (OA)."8.82Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials. ( Doherty, M; Jones, A; Zhang, W, 2004)
"Several studies have shown that colchicine exhibits an improvement in the symptoms of knee osteoarthritis (OA) but its effect on disease progression is unknown."7.88Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis? ( Agarwal, GG; Asthana, A; Das, SK; Goel, G; Srivastava, R, 2018)
"To determine whether acetaminophen or an acetaminophen-codeine combination is associated with an increased risk of acute cerebrovascular and cardiovascular events (ACCEs) in patients with osteoarthritis."7.81Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study. ( Cricelli, C; Cricelli, I; Fanelli, A; Lapi, F; Lora Aprile, P; Piccinni, C; Roberto, G; Simonetti, M, 2015)
"To identify predictors of older adults' use of exercise and/or acetaminophen, and avoidance of nonsteroidal anti-inflammatory drugs (NSAIDs) to treat their osteoarthritis pain."7.78Factors predicting older adults' use of exercise and acetaminophen for osteoarthritis pain. ( McDonald, DD; Molloy, B, 2012)
"In two recent osteoarthritis trials, alanine aminotransferase (ALT) elevations were observed more frequently in patients receiving acetaminophen 3."7.73Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials. ( Baggish, JS; Cooper, KM; Kuffner, EK; Parenti, DL; Temple, AR, 2006)
"Because there is controversy regarding the efficacy of acetaminophen in rheumatic diseases and because apparently safer nonsteroidal antiinflammatory drugs (NSAIDs) are being produced, we surveyed rheumatic disease patients about their preferences for these agents to determine the degree to which one type of therapeutic agent is preferred over the other."7.70Preference for nonsteroidal antiinflammatory drugs over acetaminophen by rheumatic disease patients: a survey of 1,799 patients with osteoarthritis, rheumatoid arthritis, and fibromyalgia. ( Lane, N; Wolfe, F; Zhao, S, 2000)
"To analyze results of treatment of osteoarthritis (OA) with acetaminophen and the nonsteroidal antiinflammatory drugs (NSAID) through a patient survey."7.70Preference for nonsteroidal antiinflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis. ( Callahan, LF; Cummins, P; Pincus, T; Swearingen, C, 2000)
"Thirty-one hospital outpatients in Thailand, 14 with rheumatoid arthritis and 17 with osteoarthritis, received 100 mg (15 patients) or 200 mg (16 patients) of controlled-release ketoprofen daily for 12 weeks."7.67Controlled-release ketoprofen in rheumatoid arthritis and osteoarthritis: comparison of two doses in Thailand. ( Chivabongs, A, 1988)
"Adult patients with pain from osteoarthritis receiving a stable dosage of HCD/APAP (i."6.77A randomized, 14-day, double-blind study evaluating conversion from hydrocodone/acetaminophen (Vicodin) to buprenorphine transdermal system 10 μg/h or 20 μg/h in patients with osteoarthritis pain. ( Landau, CJ; McCarberg, BH; Munera, C; Ripa, SR; Wen, W, 2012)
"Acetaminophen has a good risk/benefit ratio that has prompted international consensus panels to recommend its use as first-line therapy in dosages of up to 4 g/day."6.42Acetaminophen as symptomatic treatment of pain from osteoarthritis. ( Bertin, P; Jolivet-Landreau, I; Keddad, K, 2004)
" However, these drugs are associated with an increased risk for the development of adverse sequelae, including serious upper gastrointestinal side effects such as symptomatic ulcers, perforation, obstruction, and gastrointestinal bleeding."6.41Treatment of osteoarthritis with acetaminophen: efficacy, safety, and comparison with nonsteroidal anti-inflammatory drugs. ( Hochberg, MC; Shamoon, M, 2000)
"Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity."6.40Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997)
" The following variables were assessed: articular pain and swelling, AUSCAN and COCHIN functional questionnaires, grip and pinch strength, goniometry, perception of improvement, acetaminophen consumption, and simple radiography."5.51Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up. ( Fernandes, ADRC; Furtado, RNV; Machado, FS; Natour, J; Oliveira, HAV; Paschoal, NOS, 2022)
"Insured patients with a history of osteoarthritis or back pain and receiving ibuprofen, other ns-NSAIDs, COX-2i or paracetamol between 1 November, 2019 and 31 January, 2020 (study enrolment window 1) or between 1 February, 2020 and 31 October, 2020 (study enrolment window 2)."5.41Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study. ( Argyriou, G; Brash, JT; Driessen, S; Prieto-Alhambra, D; Reich, C; Seager, S; Turkmen, C; Varrassi, G; Xie, J, 2023)
"For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1."5.33Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2006)
" Given the low rates of events, at low or intermittent dosage without concurrent treatment, these 3 analgesics cannot be distinguished from each other or from background rates of serious GI toxicity."5.32Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis. ( Bruce, B; Fries, JF, 2003)
"The aim of this study was to evaluate the clinical effects of oral glucosamine sulfate, compared with placebo, on osteoarthritis in the temporomandibular joints (TMJs)."5.15No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study. ( Cahlin, BJ; Dahlström, L, 2011)
"To evaluate efficacy and safety of aceclofenac-paracetamol combination against aceclofenac alone in patients with osteoarthritis (OA) flare-up."5.14A randomized, multicentric, comparative evaluation of aceclofenac-paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up. ( Bartakke, G; Chandurkar, N; Desai, M; Kini, S; Pareek, A; Sharma, VD, 2009)
"To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)."5.14Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009)
"To assess the efficacy and safety of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA; MS-sNT), which contain morphine sulfate pellets with a sequestered naltrexone core, in treating patients with chronic, moderate-to-severe osteoarthritis (hip or knee) pain."5.14Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain. ( Hale, M; Katz, N; Morris, D; Stauffer, J, 2010)
"To assess the use of n-of-1 trials for short-term choice of drugs for osteoarthritis, with particular reference to comparing the efficacy of sustained-release [SR] paracetamol with celecoxib in individual patients."5.12Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials. ( Brown, RM; Del Mar, CB; McNairn, N; Nikles, CJ; Schluter, PJ; Yelland, MJ, 2007)
"To examine the efficacy and safety of two doses of long-acting acetaminophen in patients with osteoarthritis (OA) of the hip or knee."5.12Three-month efficacy and safety of acetaminophen extended-release for osteoarthritis pain of the hip or knee: a randomized, double-blind, placebo-controlled study. ( Altman, RD; Schweinle, JE; Temple, AR; Zinsenheim, JR, 2007)
"5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) as add-on therapy for subjects with osteoarthritis (OA) pain inadequately controlled by COX-2 nonsteroidal antiinflammatory drugs (NSAID)."5.11Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. ( Emkey, R; Jordan, D; Kamin, M; Rosenthal, N; Wu, SC, 2004)
"5 mg/acetaminophen (APAP) 325 mg combination tablets (tramadol/APAP) to existing therapy for painful osteoarthritis (OA) flare in a subset of elderly patients."5.11Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population. ( Jordan, D; Kamin, M; Rosenthal, NR; Silverfield, JC; Wu, SC, 2004)
"Subjects with moderate or greater wrist pain were randomized and stratified to 1 of the following treatments: efficacy evaluation (heat wrap, n=39; oral placebo, n=42) or blinding (oral acetaminophen, n=6; unheated wrap, n=6)."5.11Continuous low-level heat wrap therapy is effective for treating wrist pain. ( Erasala, GN; Hengehold, DA; Hun, L; Michlovitz, S; Weingand, KW, 2004)
"We provided n-of-1 trials for osteoarthritis (OA), comparing paracetamol and ibuprofen; and attention deficit hyperactivity disorder (ADHD), comparing dexamphetamine or methylphenidate and placebo."5.11Using n-of-1 trials as a clinical tool to improve prescribing. ( Clavarino, AM; Del Mar, CB; Nikles, CJ, 2005)
" We evaluated all dispensed prescriptions for either a cyclooxygenase (COX)-2 inhibitor, nonselective nonsteroidal anti-inflammatory drug or acetaminophen written by eligible general practitioners between May 2000 and June 2001 to elderly patients suffering from osteoarthritis."5.11Impact of a general practitioner educational intervention on osteoarthritis treatment in an elderly population. ( Beaulieu, M; Bessette, L; Choquette, D; Joseph, L; LeLorier, J; Rahme, E; Toubouti, Y, 2005)
"The addition of tramadol/acetaminophen tablets to existing therapy was compared with the addition of placebo in the treatment of OA flare pain."5.10Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. ( Kamin, M; Rosenthal, N; Silverfield, JC; Wu, SC, 2002)
"To compare the efficacy and safety of controlled release oxycodone given every 12 h around the clock with immediate release oxycodone-acetaminophen (APAP) given 4 times daily for osteoarthritis (OA) pain."5.09Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial. ( Boyd, RE; Caldwell, JR; Hague, JM; Hale, ME; Iwan, T; Lacouture, PG; Shi, M, 1999)
"12-week within-patient, randomised, double-blind, placebo-controlled, crossover comparison of ibuprofen with paracetamol for osteoarthritis, involving three pairs of two-week treatment periods for each participating patient."5.09Preliminary experiences with a single-patient trials service in general practice. ( Clavarino, A; Del Mar, CB; Duggan, CM; Glasziou, PP; Nikles, CJ; Yelland, MJ, 2000)
" Acetaminophen-based regimens are safer and may be as effective as NSAIDs for the treatment of osteoarthritis in many patients."5.09Educational program for nursing home physicians and staff to reduce use of non-steroidal anti-inflammatory drugs among nursing home residents: a randomized controlled trial. ( Brandt, KD; Griffin, MR; Pichert, JW; Ray, WA; Stein, CM; Taylor, JA, 2001)
"To assess the clinical efficacy of chondroitin sulfate (CS) in comparison with the nonsteroidal antiinflammatory drug (NSAID) diclofenac sodium (DS) in a medium/longterm clinical study in patients with knee osteoarthritis (OA)."5.08Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. ( Boccanera, L; Bocchi, L; Galati, M; Manopulo, R; Morreale, P; Saponati, G, 1996)
"A multicenter, double-blind, cross-over, random-order study compared the efficacy of floctafenin, 800 mg/day and acetaminophen, 3000 mg/day, in providing pain relief to 192 patients with chronic pain due to osteoarthritis in the lower limbs."5.08Floctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs. Franco-Belgian Task Force. ( du Laurier, MV; Fannius, J; Lequesne, M; Reginster, JY; Verdickt, W, 1997)
"A parallel group study for one month of 392 patients was undertaken to define the optimal dose of nimesulide for the treatment of painful osteoarthritis (OA)."5.07Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis. ( Bourgeois, P; Dreiser, RL; Lequesne, MG; Macciocchi, A; Monti, T, 1994)
"To compare the relative safety and efficacy of naproxen and acetaminophen in the treatment of osteoarthritis (OA) of the knee."5.07Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee. ( Alarcón, GS; Brooks, RH; Clegg, DO; Egger, MJ; Field, EH; Neuner, R; Skosey, JL; Ward, JR; Williams, HJ; Willkens, RF, 1993)
"Our randomized double blinded comparison of acetaminophen versus analgesic and antiinflammatory doses of ibuprofen in the treatment of 182 subjects with knee osteoarthritis (OA) systematically evaluated soft tissue tenderness and joint swelling."5.07Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1992)
"A double-blind randomized parallel group trial was undertaken to compare the acceptability and efficacy of 2 forms of analgesic treatment, DI-Antalvic (Houde Laboratories, Puteaux, France) (30 mg dextropropoxyphene and 400 mg paracetamol per capsule) and Efferalgan-Codeine (UPSA Laboratories, Rueil Malmaison, France) (30 mg codeine and 500 mg paracetamol per tablet) prescribed for 1 week at doses of 6 capsules/day and 6 tablets/day, respectively, in 141 outpatients with active osteoarthritis of the knee or hip."5.07Acceptability and efficacy of two associations of paracetamol with a central analgesic (dextropropoxyphene or codeine): comparison in osteoarthritis. ( Boissier, C; Decousus, H; Gayet, JL; Hocquart, J; Laporte-Simitsidis, S; Mismetti, P; Perpoint, B; Queneau, P; Rambaud, C, 1992)
"In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day."5.07Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991)
"This randomized, double-blind, multi-centre study was undertaken to evaluate the efficacy and safety of treatment for 4 weeks with codeine plus paracetamol versus paracetamol in relieving chronic pain due to osteoarthritis of the hip."5.06Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study. ( Andersen, HM; Branebjerg, PE; Gjøderum, O; Hvass, I; Kjærsgaard-Andersen, P; Krøner, K; Madsen, F; Nafei, A; Pedersen, L; Skov, O, 1990)
"A double-blind multicenter cross-over study was conducted on 166 outpatients with painful chronic osteoarthritis of the hip and of the femoro-tibial joints, to compare the effectiveness of glafenine and paracetamol."5.06A method for comparing analgesics: glafenine and paracetamol. Multicenter cross-over approach. ( Amor, B; Benarrosh, C, 1988)
"Twenty-eight patients with osteoarthritis participated in a prospective, double-blind, cross-over study to compare the safety and efficacy of a new combination analgesic containing ibuprofen 200 mg, paracetamol 250 mg and codeine phosphate 10 mg per tablet (Myprodol; Rio Ethicals) with a standard treatment regimen (ibuprofen 200 mg per tablet)."5.06Comparison of a standard ibuprofen treatment regimen with a new ibuprofen/paracetamol/codeine combination in chronic osteo-arthritis. ( van Vuren, JP; Vlok, GJ, 1987)
"In a double-blind cross-over trial of azapropazone and indomethacin in 20 patients with osteoarthritis of the hip and knee with four weeks on each drug, three methods of assessing pain and pain relief were used."5.05A comparison of three ways of measuring pain. ( Frank, AJ; Hort, JF; Moll, JM, 1982)
"Patients with osteoarthritis were entered into a single-blind trial comparing the effects on the gastric mucosa of a four week course of indomethacin, sulindac and a compound of paracetamol and dextropropoxyphene (Distalgesic)."5.05Histological study of the effects of three anti-inflammatory preparations on the gastric mucosa. ( Irani, MS; McIntyre, RL; Piris, J, 1981)
"In a between-patient single blind controlled trial, two groups of patients with osteoarthritis were treated for two weeks with either Fortagesic or naproxen tablets."5.04Successful use of a moderate analgesic (Fortagesic) in the symptomatic treatment of osteoarthritis. ( Rooney, GI, 1979)
"Animal experiments and uncontrolled clinical experience indicate that imipramine should relieve pain or enhance the effect of analgesics in osteoarthritis."5.04A clinical Trial of Tofranil in osteo-arthritis. ( Glick, EN, 1976)
"This meta-analysis assessed the efficacy of duloxetine versus other oral treatments used after failure of acetaminophen for management of patients with osteoarthritis."4.90The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: a systematic literature review and meta-analysis. ( Gahn, J; Han, B; Happich, M; Myers, J; Paget, MA; Price, K; Wielage, RC, 2014)
"The major clinical guidelines recommend the use of acetaminophen (acetyl-para-aminophenol [APAP]) for the treatment of mild-to-moderate symptoms of osteoarthritis (OA) and only recommend the use of nonsteroidal anti-inflammatory drugs (NSAIDs) after APAP failure."4.86The role of acetaminophen in the treatment of osteoarthritis. ( Flood, J, 2010)
"Tramadol is increasingly used for the treatment of osteoarthritis (OA) because it does not produce gastrointestinal bleeding or renal problems and does not affect articular cartilage."4.84Tramadol for osteoarthritis: a systematic review and metaanalysis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2007)
"To assess the efficacy of cyclooxygenase-2 selective inhibitors (coxibs) in osteoarthritis (OA) and their gastrointestinal, cardiovascular, renovascular, and hepatic side effects compared with traditional nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen."4.84COX-2 selective inhibitors in the treatment of osteoarthritis. ( Hochberg, M; Laine, L; Rostom, A; White, WB, 2008)
"Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage."4.83Tramadol for osteoarthritis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2006)
"To assess the best available evidence for efficacy of paracetamol (acetaminophen) in the treatment of osteoarthritis (OA)."4.82Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials. ( Doherty, M; Jones, A; Zhang, W, 2004)
"Osteoarthritis is treated with a variety of pharmacologic therapies, including acetaminophen, traditional nonsteroidal anti-inflammatory drugs, cyclo-oxygenase-2 inhibitors, intra-articular steroids, viscosupplements, glucosamine, chondroitin sulfate, capsaicin, and vitamins."4.81Pharmacologic therapy for osteoarthritis. ( Goldberg, SH; Lonner, JH; Von Feldt, JM, 2002)
"Recent controversies on the safety profiles of opioids and paracetamol (acetaminophen) have led to changes in clinical guidance on osteoarthritis (OA) management."3.88Analgesic Use and Risk for Acute Coronary Events in Patients With Osteoarthritis: A Population-based, Nested Case-control Study. ( Aragón, M; Elorza, JM; Marsal, JR; Morros, R; Pontes, C; Prieto-Alhambra, D, 2018)
"Several studies have shown that colchicine exhibits an improvement in the symptoms of knee osteoarthritis (OA) but its effect on disease progression is unknown."3.88Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis? ( Agarwal, GG; Asthana, A; Das, SK; Goel, G; Srivastava, R, 2018)
"There are contrasting positions concerning the benefit-risk ratio of acetaminophen use for osteoarthritis (OA)-related pain."3.85Regular use of acetaminophen or acetaminophen-codeine combinations and prescription of rescue therapy with non-steroidal anti-inflammatory drugs: a population-based study in primary care. ( Cricelli, C; Cricelli, I; Fanelli, A; Fornasari, D; Lapi, F; Lombardi, N; Lora Aprile, P; Simonetti, M; Vannacci, A, 2017)
"To determine whether acetaminophen or an acetaminophen-codeine combination is associated with an increased risk of acute cerebrovascular and cardiovascular events (ACCEs) in patients with osteoarthritis."3.81Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study. ( Cricelli, C; Cricelli, I; Fanelli, A; Lapi, F; Lora Aprile, P; Piccinni, C; Roberto, G; Simonetti, M, 2015)
" Paracetamol (acetaminophen) is generally recommended as a first-choice analgesic in osteoarthritis pain."3.79Managing osteoarthritis pain in the older population. ( Cunningham, E; Passmore, P, 2013)
"To identify predictors of older adults' use of exercise and/or acetaminophen, and avoidance of nonsteroidal anti-inflammatory drugs (NSAIDs) to treat their osteoarthritis pain."3.78Factors predicting older adults' use of exercise and acetaminophen for osteoarthritis pain. ( McDonald, DD; Molloy, B, 2012)
"To explore the key motivators behind selection of analgesics (nonsteroidal antiinflammatory drugs [NSAIDs], acetaminophen, and complementary medications [CMs]) by patients with osteoarthritis (OA)."3.77"It looks after me": how older patients make decisions about analgesics for osteoarthritis. ( Day, RO; Lipworth, WL; Milder, TY; Ritchie, JE; Williams, KM, 2011)
"This paper reports on a study conducted to describe what traditional and non-traditional treatments older adults with osteoarthritis use for pain management, their reported pain relief, and factors associated with use of recommended initial gold standard treatment (acetaminophen/paracetamol or non-steroidal anti-inflammatory drugs, and exercise and/or physical therapy) as designated by conventional western medicine."3.75Use of recommended osteoarthritis pain treatment by older adults. ( McDonald, DD; Merkle, D, 2009)
" For analgesia and osteoarthritis, acetaminophen (Tylenol, and others) or tramadol (Ultram, and others) are reasonable alternatives to NSAIDS."3.73NSAID alternatives. ( , 2005)
"In two recent osteoarthritis trials, alanine aminotransferase (ALT) elevations were observed more frequently in patients receiving acetaminophen 3."3.73Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials. ( Baggish, JS; Cooper, KM; Kuffner, EK; Parenti, DL; Temple, AR, 2006)
"To describe an in vivo model in the rat in which change in weight distribution is used as a measure of disease progression and efficacy of acetaminophen and two nonsteroidal anti-inflammatory drugs (NSAIDs) in a model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA)."3.72Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. ( Bove, SE; Brooker, RM; Calcaterra, SL; Guzman, RE; Huber, CM; Juneau, PL; Kilgore, KS; Schrier, DJ, 2003)
"To investigate recent national trends in nonsteroidal antiinflammatory drug (NSAID) and acetaminophen use for osteoarthritis (OA)."3.71Trends in medication use for osteoarthritis treatment. ( Ausiello, JC; Stafford, RS, 2002)
"Because there is controversy regarding the efficacy of acetaminophen in rheumatic diseases and because apparently safer nonsteroidal antiinflammatory drugs (NSAIDs) are being produced, we surveyed rheumatic disease patients about their preferences for these agents to determine the degree to which one type of therapeutic agent is preferred over the other."3.70Preference for nonsteroidal antiinflammatory drugs over acetaminophen by rheumatic disease patients: a survey of 1,799 patients with osteoarthritis, rheumatoid arthritis, and fibromyalgia. ( Lane, N; Wolfe, F; Zhao, S, 2000)
"To analyze results of treatment of osteoarthritis (OA) with acetaminophen and the nonsteroidal antiinflammatory drugs (NSAID) through a patient survey."3.70Preference for nonsteroidal antiinflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis. ( Callahan, LF; Cummins, P; Pincus, T; Swearingen, C, 2000)
"In patients with a confirmed diagnosis of osteoarthritis, acetaminophen is now recommended as first-line medical therapy."3.69Osteoarthritis: new roles for drug therapy and surgery. Interview by Peter Pompei. ( Clyman, BB, 1996)
"The traditional "aspirin first" approach to the treatment of osteoarthritis and rheumatoid arthritis is undergoing serious reappraisal."3.67Pain and inflammation. ( Calin, A, 1984)
"The analgesic effects of dextropropoxyphene and paracetamol and that of a combination of the two drugs were assessed in 24 patients who suffered from either rheumatoid arthritis or osteoarthritis."3.67Further look at dextropropoxyphene with or without paracetamol in the treatment of arthritis. ( Cunningham, TJ; Mathews, JD; Mitchell, H; Muirden, KD, 1984)
"Thirty-one hospital outpatients in Thailand, 14 with rheumatoid arthritis and 17 with osteoarthritis, received 100 mg (15 patients) or 200 mg (16 patients) of controlled-release ketoprofen daily for 12 weeks."3.67Controlled-release ketoprofen in rheumatoid arthritis and osteoarthritis: comparison of two doses in Thailand. ( Chivabongs, A, 1988)
"A survey of 763 patients with rheumatoid arthritis and 145 with osteoarthritis in six clinics in New Zealand showed no association between aspirin intake and a score designed to detect analgesic nephropathy."3.65Aspirin and the kidney. New Zealand Rheumatism Association Study. ( , 1974)
" However, long-term use of these agents will lead to inevitable side effects, even aggravate cartilage loss."3.01Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis. ( Chu, Y; Fan, Z; Guo, X; Liang, Z; Ren, W; Wang, W; Zhang, P; Zhou, G, 2023)
"Adult patients with pain from osteoarthritis receiving a stable dosage of HCD/APAP (i."2.77A randomized, 14-day, double-blind study evaluating conversion from hydrocodone/acetaminophen (Vicodin) to buprenorphine transdermal system 10 μg/h or 20 μg/h in patients with osteoarthritis pain. ( Landau, CJ; McCarberg, BH; Munera, C; Ripa, SR; Wen, W, 2012)
"The medicinal treatment of osteoarthritis (OA) is mostly symptomatic to relieve pain and incapacity with analgesics and non-steroidal anti-inflammatory drugs (NSAIDs), drugs with well-known risks."2.74Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. ( Forest, K; Girodet, PO; Jacquet, A; Mallet, L; Moore, N; Pariente, A, 2009)
"We extracted pain and adverse events outcomes from 36 systematic reviews that assessed the efficacy of paracetamol in 44 painful conditions."2.72The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews. ( Abdel Shaheed, C; Ahedi, H; Day, RO; Dmitritchenko, A; Ferreira, GE; Kamper, S; Langendyk, V; Latimer, J; Lin, C; Maher, CG; McLachlan, AJ; McLachlan, H; Saragiotto, B; Stanaway, F, 2021)
" Patients were allocated at random to receive 2 tablets 3-times daily of either treatment for 6 weeks and were then crossed over to the alternative treatment at the same dosage for a further 6 weeks."2.65Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis. ( Boston, PF; Matts, SG, 1983)
"Two studies on 41 patients with osteoarthrosis of the hip or knee have shown fenoprofen-a compound with analgesic and anti-inflammatory properties-to be an effective addition to the drug treatment of these conditions."2.64Fenoprofen in treatment of osteoarthrosis of hip and knee. ( Hart, FD; Huskisson, EC; Wojtulewski, JA, 1974)
" Furthermore, there have been recent concerns over the safety profile of paracetamol, with reports of gastrointestinal, cardiovascular, hepatic and renal adverse events."2.61Safety of Paracetamol in Osteoarthritis: What Does the Literature Say? ( Arden, N; Avouac, B; Conaghan, PG; Migliore, A; Rizzoli, R, 2019)
"Acetaminophen has been commonly used as the fi rst-line treatment for OA pain and cLBP, but its long-term use is not recommended based on recent evidence."2.61Evidence-Based Recommendations on the Pharmacological Management of Osteoarthritis and Chronic Low Back Pain: An Asian Consensus ( Ip, AKK; Murakami, T; Shin, HK; Sun, WZ; Tam, CK; Ushida, T; Wang, JH; Williamson, OD; Yabuki, S, 2019)
"Osteoarthritis is a common progressive disease in older adults, and those affected often have impaired physical function, co-existing disease states, and reduced quality of life."2.55Move it or Lose it. Is it Reasonable for Older Adults with Osteoarthritis to Continue to Use Paracetamol in Order to Maintain Physical Activity? ( Cooke, J; Cooper, G; Lee, K; Shield, A, 2017)
" A good knowledge of the different strategies to decrease the gastrointestinal and cardiovascular toxic effects of NSAIDs is key to the management of OA."2.52Safety and efficacy of paracetamol and NSAIDs in osteoarthritis: which drug to recommend? ( Frazier, A; Latourte, A; Richette, P, 2015)
" However, there is concern for the possible side effects resulting from long term use of those medications."2.52Controversy: hirudotherapy (leech therapy) as an alternative treatment for osteoarthritis. ( Bunawan, NC; Gunawan, F; Turner, JH; Wibowo, YR, 2015)
" NSAIDs long-term use associated with serious adverse effects."2.48[Antiinflammatory therapy in ostheoarthritis including omega 3 and omega 6 fatty acids]. ( Dzielska-Olczak, M; Nowak, JZ, 2012)
"Osteoarthritis (OA) is the most common cause of disability in older adults, and although analgesic use can be helpful, it can also result in adverse drug events."2.48Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioid analgesics. ( Hanlon, JT; Marcum, ZA; O'Neil, CK, 2012)
"Treatment with tramadol or opioids is usually reserved for severe pain associated with OA."2.47Treatment options for osteoarthritis: considerations for older adults. ( Dunican, KC; Lynch, AM; Seed, SM, 2011)
"In this systematic review we present information relating to the benefits and harms of the following interventions: differences in efficacy among different oral NSAIDs, between oral and topical NSAIDs, and between oral NSAIDs and alternative analgesics; dose-response relationship of oral NSAIDs; and H(2) blockers, misoprostol, or proton pump inhibitors to mitigate gastrointestinal adverse effects of oral NSAIDs."2.46NSAIDs. ( Gøtzsche, PC, 2010)
" NSAIDs are typically more effective than acetaminophen; however, because of adverse effects associated with long-term use of NSAIDS, acetaminophen is considered first-line therapy."2.45Osteoarthritis: a review of treatment options. ( Dunican, KC; Lynch, AM; Seed, SM, 2009)
"In this systematic review we present information relating to the benefits and harms of the following interventions: alternative analgesics, H(2) blockers, misoprostol, NSAIDs (systemic, topical, differences in efficacy between, dose-response relationship of), proton pump inhibitors."2.44NSAIDs. ( Gøtzsche, PC, 2007)
"Primary osteoarthritis is mostly related to aging, whereas, secondary osteoarthritis is caused by another disease or condition."2.43Osteoarthritis. ( Mahajan, A; Tandon, V; Verma, S, 2005)
" Appropriately dosed and monitored use of opioids for OA pain, when more conservative methods have failed, has potentially fewer life-threatening complications associated with it than the more commonly and often less successfully employed pharmacotherapeutic approaches to care."2.43The use of opioids in the treatment of osteoarthritis: when, why, and how? ( Bajwa, ZH; Goodwin, JL; Kraemer, JJ, 2005)
" Because NSAIDs are associated with adverse renal effects, they should be used cautiously in patients with advanced renal disease."2.43Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease. ( Johnson, J; Weinryb, J, 2006)
"Acetaminophen has a good risk/benefit ratio that has prompted international consensus panels to recommend its use as first-line therapy in dosages of up to 4 g/day."2.42Acetaminophen as symptomatic treatment of pain from osteoarthritis. ( Bertin, P; Jolivet-Landreau, I; Keddad, K, 2004)
" However, these drugs are associated with an increased risk for the development of adverse sequelae, including serious upper gastrointestinal side effects such as symptomatic ulcers, perforation, obstruction, and gastrointestinal bleeding."2.41Treatment of osteoarthritis with acetaminophen: efficacy, safety, and comparison with nonsteroidal anti-inflammatory drugs. ( Hochberg, MC; Shamoon, M, 2000)
"Pain is the most prominent symptom and clinical finding in osteoarthritis (OA)."2.41Treatment of chronic pain in osteoarthritis: do opioids have a clinical role? ( Lipman, AG, 2001)
" During repeated dosage with the specific COX-2 inhibitors, the 24 hour urinary excretion of sodium is only inhibited for the first day of treatment while the excretion of sodium is still decreased over the first 3 hours after the individual doses."2.41Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol). ( Day, RO; Graham, GG; Graham, RI, 2002)
"Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity."2.40Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997)
"Chronic pain affects 75 million US citizens."2.40Non-NSAID pharmacologic treatment options for the management of chronic pain. ( Schnitzer, TJ, 1998)
"Symptomatic treatments for osteoarthritis (OA) provide only small-to-moderate efficacy over placebo in randomised controlled trials (RCTs)."1.62Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis. ( Doherty, M; Lei, G; Persson, MSM; van Middelkoop, M; Wei, J; Xiong, Y; Zeng, C; Zhang, W, 2021)
"Osteoarthritis is a common debilitating condition affecting a substantial portion of the population and is an accepted consequence of ageing and overuse."1.56Why are we still using opioids for osteoarthritis? ( Oettinger, J; Yip, K, 2020)
" Less frequent dosing of the ERP formulation may explain the difference in usage patterns."1.43Prescription usage patterns of two formulations of paracetamol in osteoarthritis: Australia-wide experience 2008-11. ( Calcino, G; Dunagan, F; Ortiz, M, 2016)
"Tramadol is an option in the case patients will not respond satisfactorily to NSAIDs."1.39Pharmacologic treatment of hand-, knee- and hip-osteoarthritis. ( Bobacz, K, 2013)
"Recommended pain treatments for osteoarthritis (OA) and chronic low back pain (CLBP) are suboptimal, and limited information is available regarding patterns of pharmacotherapy among patients with these conditions."1.38Therapy switching, augmentation, and discontinuation in patients with osteoarthritis and chronic low back pain. ( Emery, P; Gore, M; Leslie, DL; Sadosky, AB; Tai, KS, 2012)
"When rofecoxib was withdrawn in 2004, paracetamol should have been offered as replacement."1.35Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market. ( Barozzi, N; Tett, SE, 2009)
"For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1."1.33Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2006)
" It is recommended to use the same dosages and dosage forms that the patient used before the trial, to start the trial with a run-in period, to formulate both general and individualized decision rules regarding the efficacy of treatment, to adjust treatment policies immediately after the trial, and to provide adequate instructions and support if treatment is adjusted."1.33Conducting research in individual patients: lessons learnt from two series of N-of-1 trials. ( de Vries, TP; Stalman, WA; van der Windt, DA; Wegman, AC, 2006)
" Given the low rates of events, at low or intermittent dosage without concurrent treatment, these 3 analgesics cannot be distinguished from each other or from background rates of serious GI toxicity."1.32Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis. ( Bruce, B; Fries, JF, 2003)
"(1) The treatment of osteoarthritis is symptomatic, and relies first and foremost on physical therapy."1.31Treatment of osteoarthritic pain: systemic drug therapy is not always necessary. ( , 2000)
"Osteoarthritis is a chronic disease that has exacerbations and remissions."1.29Osteoarthritis treatment update. Minimizing pain while limiting patient risk. ( Schnitzer, TJ, 1993)

Research

Studies (228)

TimeframeStudies, this research(%)All Research%
pre-199031 (13.60)18.7374
1990's31 (13.60)18.2507
2000's90 (39.47)29.6817
2010's61 (26.75)24.3611
2020's15 (6.58)2.80

Authors

AuthorsStudies
Paschoal, NOS1
Natour, J1
Machado, FS1
Oliveira, HAV1
Fernandes, ADRC1
Furtado, RNV1
Wang, Y1
Fan, M1
Wang, H1
You, Y1
Wei, C1
Liu, M1
Luo, A1
Xu, X1
Duan, X1
Pickering, G1
Mezouar, L1
Kechemir, H1
Ebel-Bitoun, C1
Xie, J1
Brash, JT1
Turkmen, C1
Driessen, S1
Varrassi, G1
Argyriou, G1
Seager, S1
Reich, C1
Prieto-Alhambra, D2
Wang, W1
Chu, Y1
Zhang, P1
Liang, Z1
Fan, Z1
Guo, X1
Zhou, G1
Ren, W1
Yip, K1
Oettinger, J1
Apostu, D1
Lucaciu, O1
Mester, A1
Oltean-Dan, D1
Baciut, M1
Baciut, G1
Bran, S1
Onisor, F1
Piciu, A1
Pasca, RD1
Maxim, A1
Benea, H1
Vicentini, M1
Mancuso, P1
Giorgi Rossi, P1
Di Pede, S1
Pellati, M1
Gandolfi, A1
Zoboli, D1
Riccò, D1
Busani, C1
Ferretti, A1
Banks, C1
Hughes, K1
Simpkins, C1
Elliott, DP1
Kloppenburg, M1
Berenbaum, F1
Trivedi, S1
Fang, W1
Ayyalasomayajula, I1
Vangsness, CT1
Zeng, C2
Zhang, W4
Doherty, M5
Persson, MSM2
Mallen, C3
Swain, S1
Li, X1
Wei, J2
Lei, G2
Zhang, Y1
Chandan, JS1
Zemedikun, DT1
Thayakaran, R1
Byne, N1
Dhalla, S1
Acosta-Mena, D1
Gokhale, KM1
Thomas, T1
Sainsbury, C1
Subramanian, A1
Cooper, J1
Anand, A1
Okoth, KO1
Wang, J1
Adderley, NJ1
Taverner, T1
Denniston, AK1
Lord, J1
Thomas, GN1
Buckley, CD1
Raza, K1
Bhala, N1
Nirantharakumar, K1
Haroon, S1
Paglia, DN1
Kanjilal, D1
Kadkoy, Y1
Moskonas, S1
Wetterstrand, C1
Lin, A1
Galloway, J1
Tompson, J1
Culbertson, MD1
O'Connor, JP1
Abdel Shaheed, C1
Ferreira, GE1
Dmitritchenko, A1
McLachlan, AJ1
Day, RO4
Saragiotto, B1
Lin, C1
Langendyk, V1
Stanaway, F1
Latimer, J1
Kamper, S1
McLachlan, H1
Ahedi, H1
Maher, CG1
D'Arcy, Y1
Mantyh, P1
Yaksh, T1
Donevan, S1
Hall, J1
Sadrarhami, M1
Viktrup, L1
Xiong, Y1
van Middelkoop, M1
Vannacci, A1
Lombardi, N1
Simonetti, M2
Fornasari, D1
Fanelli, A2
Cricelli, I2
Cricelli, C2
Lora Aprile, P2
Lapi, F2
Inacio, MCS1
Cashman, K1
Pratt, NL1
Gillam, MH1
Caughey, G1
Graves, SE1
Roughead, EE1
Rasmussen, S1
Pontes, C1
Marsal, JR1
Elorza, JM1
Aragón, M1
Morros, R1
Benitez-Camps, M1
Morros Padrós, R1
Pera-Pujadas, H1
Dalfó Baqué, A1
Bayó Llibre, J1
Rebagliato Nadal, O1
Cortès Martinez, J1
García Sangenís, A1
Roca Saumell, C1
Coll de Tuero, G1
Vinyoles-Bargalló, E1
Majeed, MH1
Sherazi, SAA1
Bacon, D1
Bajwa, ZH2
Trentalange, M1
Runels, T1
Bean, A1
Kerns, RD1
Bair, MJ1
Brody, AA1
Brandt, CA1
Hwang, U1
Wiet, SG1
Boyle, KE1
Bass, MB1
Conaghan, PG4
Arden, N1
Avouac, B1
Migliore, A1
Rizzoli, R1
Yabuki, S1
Ip, AKK1
Tam, CK1
Murakami, T1
Ushida, T1
Wang, JH1
Shin, HK1
Sun, WZ1
Williamson, OD1
Fogleman, CD1
Laba, TL1
Brien, JA1
Fransen, M1
Jan, S1
Bobacz, K1
Passmore, P1
Cunningham, E1
Bertin, P2
Becquemont, L1
Corruble, E1
Derumeaux, G1
Falissard, B1
Hanon, O1
Pinget, M1
Forette, F1
Richette, P2
Wise, J1
Myers, J1
Wielage, RC1
Han, B1
Price, K1
Gahn, J1
Paget, MA1
Happich, M1
Berry, L1
Ma, J1
Talukdar, R1
Gainers-Hasugluw, V1
Hay, E2
Traynor, K1
Latourte, A1
Frazier, A1
Roberts, E1
Gunawan, F1
Wibowo, YR1
Bunawan, NC1
Turner, JH1
Roberto, G1
Piccinni, C1
Ortiz, M1
Calcino, G1
Dunagan, F1
Serpell, M1
McSkimming, P1
Junor, R1
Dickerson, S1
Young, SE1
Bothwell, JD1
Walsh, RM1
Sulich, A1
Lee, K1
Cooke, J1
Cooper, G1
Shield, A1
Srivastava, R1
Das, SK1
Goel, G1
Asthana, A1
Agarwal, GG1
Pavlicević, I2
Kuzmanić, M2
Rumboldt, M2
Rumboldt, Z2
Lee, A1
Tsang, CK1
Siu, HK1
Wong, WC1
Wong, SY1
Barozzi, N1
Tett, SE1
Saccomanni, B1
Merkle, D1
McDonald, DD3
Pareek, A1
Chandurkar, N1
Sharma, VD1
Desai, M1
Kini, S1
Bartakke, G1
Chandran, P1
Pai, M1
Blomme, EA1
Hsieh, GC1
Decker, MW1
Honore, P1
Gatti, A1
Sabato, AF1
Carucci, A1
Bertini, L1
Mammucari, M1
Occhioni, R1
Gøtzsche, PC2
Jacquet, A1
Girodet, PO1
Pariente, A1
Forest, K1
Mallet, L1
Moore, N1
Flood, J1
Rosemann, T1
Huber, CA1
Rosemann, A1
Katz, N1
Hale, M1
Morris, D1
Stauffer, J1
Seed, SM2
Dunican, KC2
Lynch, AM2
White, WB2
Campbell, P1
Dworkin, RH1
Peirce-Sandner, S1
Turk, DC1
McDermott, MP1
Gibofsky, A1
Simon, LS1
Farrar, JT1
Katz, NP1
Milder, TY1
Lipworth, WL1
Williams, KM1
Ritchie, JE1
Burnett, BP1
Bitto, A1
Altavilla, D1
Squadrito, F1
Levy, RM1
Pillai, L1
Cahlin, BJ1
Dahlström, L1
Roth, SH1
Anderson, S1
Gore, M1
Sadosky, AB1
Leslie, DL1
Tai, KS1
Emery, P1
Walsh, S1
Ripa, SR1
McCarberg, BH1
Munera, C1
Wen, W1
Landau, CJ1
Cheng, DS1
Visco, CJ1
Dzielska-Olczak, M1
Nowak, JZ1
Bennell, KL1
Hunter, DJ1
Hinman, RS1
Fisher, JE1
Ballantyne, PJ1
Hawker, GA1
O'Neil, CK1
Hanlon, JT1
Marcum, ZA1
Molloy, B1
Almaawi, A1
Wang, HT1
Ciobanu, O1
Rowas, SA1
Rampersad, S1
Antoniou, J1
Mwale, F1
Courtney, P1
Abramson, SB1
Towheed, TE3
Petersson, I1
Goldberg, SH1
Von Feldt, JM1
Lonner, JH1
Hochberg, MC6
Brandt, KD10
Vallerand, AH1
Judd, MJ1
Wells, G2
HART, FD3
Fries, JF1
Bruce, B1
Bove, SE1
Calcaterra, SL1
Brooker, RM1
Huber, CM1
Guzman, RE1
Juneau, PL1
Schrier, DJ1
Kilgore, KS1
Emkey, R1
Rosenthal, N2
Wu, SC3
Jordan, D2
Kamin, M3
Brandt, K1
Scott, DL1
Kingsley, G1
Rosenthal, NR1
Silverfield, JC2
Jones, A1
Idänpään-Heikkilä, JE1
Idänpään-Heikkilä, JJ1
Klaukka, T1
Tarone, RE1
Lipworth, L1
McLaughlin, JK1
Buescher, JS1
Meadows, S1
Saseen, J1
Tugwell, P1
O'Connor, AM1
Santesso, NA1
Neame, R1
Keddad, K1
Jolivet-Landreau, I1
Michlovitz, S1
Hun, L1
Erasala, GN1
Hengehold, DA1
Weingand, KW1
Nachamie, HL1
McNicoll, L1
Dosa, D1
Ellman, MH1
Curran, J1
Nikles, CJ3
Clavarino, AM1
Del Mar, CB3
Wu, CW1
Kalunian, KC1
Stöve, J1
Pavelka, K1
Sprott, H1
Shen, H1
Gay, S1
Aeschlimann, A1
Mahajan, A1
Verma, S1
Tandon, V1
Dickson, DJ1
Rahme, E1
Choquette, D1
Beaulieu, M1
Bessette, L1
Joseph, L2
Toubouti, Y1
LeLorier, J1
Goodwin, JL1
Kraemer, JJ1
Rodnick, JE1
Maxwell, L1
Judd, MG1
Catton, M1
Bannwarth, B1
Graham, GG2
Yelland, MJ2
McNairn, N1
Schluter, PJ1
Brown, RM1
Richards, JB1
Schwartzman, K1
Kreiger, N1
Tenenhouse, A1
Goltzman, D1
Cepeda, MS2
Camargo, F2
Zea, C2
Valencia, L2
Johnson, J1
Weinryb, J1
Vestergaard, P1
Rejnmark, L1
Mosekilde, L1
Wegman, AC1
van der Windt, DA1
Stalman, WA1
de Vries, TP1
Kuffner, EK1
Temple, AR2
Cooper, KM1
Baggish, JS1
Parenti, DL1
Stitik, TP1
Altschuler, E1
Foye, PM1
Altman, RD2
Zinsenheim, JR1
Schweinle, JE1
Laine, L1
Rostom, A1
Hochberg, M1
McMahon, K1
Nelson, M1
Jones, G1
Lewis, D1
Lewis, B1
Sturrock, RD1
Calin, A1
Matts, SG1
Boston, PF1
Mitchell, H1
Cunningham, TJ1
Mathews, JD1
Muirden, KD1
Frank, AJ1
Moll, JM1
Hort, JF1
Doyle, DV1
Dieppe, PA1
Scott, J1
Huskisson, EC3
Wheatley, D1
McIntyre, RL1
Irani, MS1
Piris, J1
Griffin, MR3
Liang, MH1
Pincus, T4
Ray, WA3
Hawkey, CJ1
Senn, S1
Bakshi, R1
Ezzet, N1
Bourgeois, P1
Dreiser, RL1
Lequesne, MG1
Macciocchi, A1
Monti, T1
Helliwell, PS1
Dempsey, O1
Faulkner, P1
Deacon, A1
Henderson, EB1
Smith, EC1
Pegley, F1
Blake, DR1
March, L1
Irwig, L1
Schwarz, J1
Simpson, J1
Chock, C1
Brooks, P1
Flynn, MA1
Irvin, W1
Krause, G1
Bradley, JD3
Williams, HJ1
Ward, JR1
Egger, MJ1
Neuner, R1
Brooks, RH1
Clegg, DO1
Field, EH1
Skosey, JL1
Alarcón, GS1
Willkens, RF1
Schnitzer, TJ3
Clyman, BB1
Morreale, P1
Manopulo, R1
Galati, M1
Boccanera, L1
Saponati, G1
Bocchi, L1
Kuntz, D1
Brossel, R1
Fox, SM1
Johnston, SA1
Lequesne, M1
Fannius, J1
Reginster, JY1
Verdickt, W1
du Laurier, MV1
Eccles, M1
Freemantle, N1
Mason, J1
Tindall, WN1
Caldwell, JR1
Hale, ME1
Boyd, RE1
Hague, JM1
Iwan, T1
Shi, M1
Lacouture, PG1
Wolfe, F1
Zhao, S1
Lane, N1
Swearingen, C1
Cummins, P1
Callahan, LF1
Nuovo, J1
Glasziou, PP1
Duggan, CM1
Clavarino, A1
Creamer, P1
Shamoon, M2
Hungin, AP1
Kean, WF1
Karnon, J1
Qizilbash, N1
Vial, F1
Bouaziz, H1
Mekler, G1
Cornet, C1
Merle, M1
Laxenaire, MC1
Stein, CM2
Byrd, V1
Shorr, R1
Pichert, JW2
Gideon, P1
Arnold, K1
Taylor, JA1
MacLean, CH1
Lipman, AG1
Terchek, M1
Baker, J1
Goeckeritz, B1
Loebl, D1
Bierma-Zeinstra, SM1
Bohnen, AM1
Berger, MY1
Thomas, S1
Henderson, P1
Graham, RI1
Ausiello, JC1
Stafford, RS1
Veje, K1
Hyllested, JL1
Østergaard, K1
Liyanage, SP1
Tambar, PK1
Rooney, GI1
Glick, EN1
Andrews, CJ1
Cohen, L1
Crail, RB1
Douch, G1
Sheldon, MG1
Wray, KA1
Haslock, I1
Omar, AS1
Wright, V1
Katz, BP2
Kalasinski, LA2
Ryan, SI2
Boissier, C1
Perpoint, B1
Laporte-Simitsidis, S1
Mismetti, P1
Hocquart, J1
Gayet, JL1
Rambaud, C1
Queneau, P1
Decousus, H1
Miller, DR1
Ginsberg, F1
Kjærsgaard-Andersen, P1
Nafei, A1
Skov, O1
Madsen, F1
Andersen, HM1
Krøner, K1
Hvass, I1
Gjøderum, O1
Pedersen, L1
Branebjerg, PE1
Vignon, E1
Mathieu, P1
Broquet, P1
Louisot, P1
Richard, M1
Geary, U1
Murphy, M1
O'Brien, A1
Coakley, D1
Walsh, JB1
Amor, B1
Benarrosh, C1
Chivabongs, A1
Vlok, GJ1
van Vuren, JP1
Quinet, RJ1
Finkbeiner, G1
Wojtulewski, JA2
Maneksha, S1
Solomon, L1
Abrams, G1
Waltham-Weeks, CD1
Shenfield, GM1
Taylor, RT1
Wettreich, W1
Tudhope, GR1
Thorpe, P1
Frank, O1
Klemmayer, K1

Clinical Trials (25)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Cluster Randomised Trial to Measure the Impact of a Free Distribution of Paracetamol to Osteoarthritic Patients on Non-steroidal Anti-inflammatory Drugs (NSAID) and Proton Pump Inhibitors (PPI) Prescription[NCT02691754]16 participants (Actual)Interventional2012-11-30Completed
A Randomized Controlled Study Evaluating Suprainguinal Fascia Iliaca Compartment Block in Direct Anterior Approach to Total Hip Arthroplasty - A Pilot Study[NCT05237479]0 participants (Actual)Interventional2022-06-30Withdrawn (stopped due to Study never approved by IRB or initiated)
Ultrasound Guided Sacroiliac Joint Injections With Ketorolac Versus Corticosteroid: A Prospective Non-inferiority Study[NCT06081101]Early Phase 180 participants (Anticipated)Interventional2024-01-31Not yet recruiting
The Effect of Glucosamine Sulphate on Structural Disease Progression in Knee Osteoarthritis and the Cost-effectiveness of Glucosamine Sulphate for Knee Arthritis.[NCT00513422]Phase 4600 participants (Anticipated)Interventional2007-10-31Active, not recruiting
National Observatory on the Therapeutic Management in Ambulatory Care Patients Aged 65 and Over, With Diabetes Type 2, Chronic Pain or Atrial Fibrillation[NCT01065909]3,491 participants (Actual)Observational2009-05-31Completed
Relevance of the Interaction Between Antihypertensive and Antirheumatic Drugs in a Family Practice[NCT00631514]Phase 488 participants (Actual)Interventional2005-01-31Completed
Efficiency And Quality In Post-Surgical Pain Therapy After Discharge[NCT05221866]711 participants (Actual)Interventional2022-03-14Completed
UControlPain App (This is the Official IRB Title)[NCT03833648]60 participants (Actual)Interventional2019-06-19Completed
Randomized Double-Blind Study of Food Supplement Phytalgic on Symptoms of Osteoarthritis[NCT00666523]81 participants (Actual)Interventional2007-01-31Completed
A Randomized, Double-Blind Study Evaluating the Dose Conversion From Vicodin® to Buprenorphine Transdermal System (BTDS) in Subjects With Osteoarthritis (OA) Pain[NCT00312572]Phase 3204 participants (Actual)Interventional2003-06-30Completed
Role of Vitamin D (Alphacalcidol) Supplement to Reduce Pain and Cartilage Oligomeric Matrix Protein Serum Levels in Geriatric Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Study[NCT04405960]Phase 3146 participants (Actual)Interventional2017-07-01Completed
A Randomized, Double-Blind, Placebo-Controlled Study Evaluating Acetaminophen Extended Release (3900 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee.[NCT00240799]Phase 3542 participants (Actual)InterventionalCompleted
A Randomized, Double-Blind, Placebo-Controlled Study Evaluating Acetaminophen Extended Release (1950 mg/Day or 3900 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee[NCT00240786]Phase 3483 participants (Actual)Interventional2002-04-30Completed
Effectiveness of Percutaneous Microelectrolysis in the Decrease of Pain in Myofascial Trigger Points: Evaluation Through Algometry and Visual Analog Scale. Randomized Controlled Trial.[NCT03636386]48 participants (Actual)Interventional2018-05-23Completed
MiniTightRope Suspensionplasty Compared With Ligamentous Reconstruction Tendon Interposition for the Treatment of Basilar Thumb Arthritis. A Randomized Clinical Trial[NCT02591368]7 participants (Actual)Interventional2015-10-31Terminated
Arthroscopic Surgery Versus Non-surgical Treatment of Osteoarthritis of the Knee[NCT00158431]Phase 3186 participants (Actual)Interventional1999-01-31Completed
Clinical Evaluation of Condrosulf 800 mg in the Treatment of Symptomatic OA of the Hand: a 6-month, Double-blind, Placebo Controlled Study[NCT00291499]Phase 3163 participants (Actual)Interventional2005-06-30Completed
Study of the Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee[NCT00604539]Phase 370 participants (Anticipated)Interventional2008-02-29Completed
A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755]62 participants (Actual)Interventional2017-07-01Completed
Effectiveness of Distal Peripheral Nerve Blocks on Postoperative Pain Management After Ambulatory Thumb Resection Arthroplasty.[NCT01597479]Phase 452 participants (Actual)Interventional2012-02-29Completed
The Effects of Bariatric Surgery Weight Loss on Knee Pain in Patients With Osteoarthritis of the Knee[NCT00752765]30 participants (Anticipated)Observational2008-09-30Completed
Assessment and Treatment Responses to Patient Education and Basic Body Awareness Therapy in Hip Osteoarthritis: a Randomized Controlled Trial[NCT02884531]101 participants (Actual)Interventional2015-10-31Completed
Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722772]60 participants (Anticipated)Interventional2016-02-29Recruiting
Efficacy of Subcutaneous Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722811]60 participants (Anticipated)Interventional2016-02-29Recruiting
Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721]Phase 2/Phase 350 participants (Actual)Interventional2015-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

The Percentage of Subjects Who Completed the 14-day Double-blind Phase.

The indicator variable was 1 = completion, and 0 = noncompletion. For the primary efficacy analysis, the percentage of subjects who completed the double-blind phase was computed with its 95% confidence interval (CI) for each treatment regimen (starting dose of BTDS 10 or BTDS 20) across and within baseline Vicodin® stratum (15 to 22.5mg/day vs >22.5 to 30 mg/day as determined by the daily average hydrocodone dose during the run-in period). (NCT00312572)
Timeframe: 14 days

,,
InterventionPercentage of Participants (Number)
15 - 22.5 mg HCD (Stratum 1)more than 22.5 - 30 mg HCD (Stratum 2)Overall
Combined Total858284
Double-blind BTDS 10/20888587
Double-blind BTDS 20837982

Pain Intensity (PI)

Magnitude of pain expressed in millimeters (mm) referred by participants. PI was evaluated through visual analogue scale at moment of performing pressure algometry test in the sensitive point of upper trapezius muscle. PI was assessed with an analogous visual scale where the participant will mark the pain generated by the algometry on a scale of 1 to 100 millimeters. PI was valued in four occasions: PI1 pre (baseline), PI1 post, PI 2 (at day 3) and PI 3 (at day 7). (NCT03636386)
Timeframe: PIpre1 (baseline), PIpost1 (post baseline), PI2 (Day 3), PI3 (Day 7), assessed an average of 3 minutes at each session

,
Interventionmm (Mean)
PIpre1PIpost1PI2PI3PIdiff1-1PIdiff2-1PIdiff3-1
Control Group (Ultrasound Therapy)31.424.823.820.0-6.6-7.6-11.5
Percutaneous Microelectrolysis Group (MEP)32.124.621.618.1-7.5-10.5-14.0

Pain Pressure Threshold (PPT)

Pain Intensity expressed in kilograms per square centimeter(kg/cm2) reported by participants when performing algometry test at sensitive point of upper trapezius muscle. PPT was valued in four occasions: PPT1 pre (baseline), PPT1 post, PPT 2 (at day 3) and PPT 3 (at day 7). PPT will be evaluated through the BASELINE® pressure algometer. (NCT03636386)
Timeframe: PPTpre1 (baseline), PPTpost1 (post baseline), PPT2 (Day 3), PPT3 (Day 7), assessed an average of 30 minutes at each session

,
InterventionKg/cm2 (Mean)
PPTpre1PPTpost1PPT2PPT3PPTdiff1-1PPTdiff2-1PPTdiff3-1
Control Group (Ultrasound Therapy)1.41.61.61.70.20.20.3
Percutaneous Microelectrolysis Group (MEP)1.41.61.71.90.20.40.5

Change in Functional Index for Hand Osteoarthritis Dreiser's Score (FIHOA) in the Target Hand

"Functional Index for Hand Osteoarthritis (Dreiser's Index). Range 0-30 Patients reported the severity of their symptoms by answering a set of 10 questions. Severity was rated on a numerical scale (0 = possible without difficulty, 1 = possible with slight difficulty, 2 =possible with great difficulty, and 3 = impossible), being 30 points the worst possible pain score.~Change calculated as difference between the month 6 value and baseline value~Target hand defined as the patient's most symptomatic hand or, when both hands were equally painful, the patient's dominant hand" (NCT00291499)
Timeframe: 6 month

Interventionscore on a scale (Mean)
Chondroitin 4&6 Sulfate (Condrosulf)-2.9
Placebo-0.7

Change in Global Spontaneous Pain Intensity of Target Hand

Intensity of global spontaneous pain is evaluated by the patient himself on a Huskisson's visual analogue scale (VAS) of 100 mm. 0=no pain 100=max pain Change calculated as difference between Month 6 value and baseline value target hand is defined as the patient's most symptomatic hand or, when both hands were equally painful, the patient's dominant hand. (NCT00291499)
Timeframe: 6 months

Interventionmm (Mean)
Chondroitin 4&6 Sulfate (Condrosulf)-20
Placebo-11.3

Change in Grip Strength

"Grip strength determined on both hands using a Jamar dynamometer.Patients were required to grip the dynamometer handle and squeeze as hard as possible according to their individual pain limits. The right hand grip was measured first, then the left; this procedure was performed 3 times. The mean value of these 3 measurements was recorded.~Change calculated as difference between the month 6 value and baseline value" (NCT00291499)
Timeframe: 6 months

InterventionKg/cm^2 (Mean)
Chondroitin 4&6 Sulfate (Condrosulf)2.5
Placebo0.6

Change in Morning Stiffness Duration

Change in morning stiffness duration calculated as the difference between the month 6 value and the baseline value (NCT00291499)
Timeframe: 6 months

Interventionminutes (Mean)
Chondroitin 4&6 Sulfate (Condrosulf)-4.8
Placebo0.3

Consumption of Paracetamol

Total consumption (between ^baseline and month 6) of paracetamol (500 mg tablets) reported by the patients on a daily diary (NCT00291499)
Timeframe: 6 months

Interventiontablets/week (Mean)
Chondroitin 4&6 Sulfate (Condrosulf)1.9
Placebo2.0

Maximum Pain Intensity, Rescue Analgesia, Nausea and Vomiting Incidence, Use of Ondansetron for NVPO, Efectiveness of Ondansetron

Number of participants with Maximum pain intensity NVS > 3; Rescue analgesia; Nausea and Vomiting incidence; use of ondansetron for NVPO; Ondansetron being effective (number of participants for whom ondansetron was effective to stop NVPO). (NCT01597479)
Timeframe: Up to 48 hours

,
Interventionparticipants (Number)
Maximum pain intensity 24h (NVS>3)Maximum pain intensity 48h (NVS >3)Rescue analgesia 24h (n)Rescue Analgesia 48h (n)Nausea and vomiting 24h (n)Nausea and vomiting 48h (n)Use of ondansetron 24h (n)Use of ondansetron 48h (n)Effectiveness of ondansetron 24hEfectiveness of ondansetron 48h
dPNBs Group8525101010
Non dPNBs Group242117171055542

Proportion of Patients Who Experienced Moderate to Severe Pain During First and Second Postoperative Day

Pain scores assessed using pain numerical visual scale (NVS) of 0-10 (o= no pain and 10= worst pain imaginable). We defined mild pain (NVS 0-3); moderate pain (NVS 4-6) and severe pain (NVS 7-10).The analysis of this variable at the end of the study will confirm or not the effectiveness of dPNBs for management of postoperative pain after TRA. (NCT01597479)
Timeframe: Up to 48 hours

,
Interventionpercentage of patients (Number)
Pain intensity NVS>3 on call 24hPain intensity NVS>3 on call 48h
Distal Peripheral Nerve Blocks Group (dPNBs Group)8.34.2
Non Distal Peripheral Nerve Blocks (Non dPNBs Group)80.842.3

Reviews

74 reviews available for acetaminophen and Osteoarthritis

ArticleYear
Relative safety and efficacy of topical and oral NSAIDs in the treatment of osteoarthritis: A systematic review and meta-analysis.
    Medicine, 2022, Sep-09, Volume: 101, Issue:36

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Pain; Quality of Lif

2022
Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study.
    Drugs, 2023, Volume: 83, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Cohort Studies; COVID-19; COVID-1

2023
Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis.
    International immunopharmacology, 2023, Volume: 116

    Topics: Acetaminophen; Cartilage, Articular; Humans; Inflammation; Macrophages; Osteoarthritis

2023
Systemic drugs with impact on osteoarthritis.
    Drug metabolism reviews, 2019, Volume: 51, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin

2019
Osteoarthritis year in review 2019: epidemiology and therapy.
    Osteoarthritis and cartilage, 2020, Volume: 28, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2020
Pharmacotherapeutic considerations and options for the management of osteoarthritis in women.
    Expert opinion on pharmacotherapy, 2020, Volume: 21, Issue:5

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal;

2020
The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews.
    The Medical journal of Australia, 2021, Volume: 214, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Case-Control Studies; Craniotomy; Data Management; Humans;

2021
Treating osteoarthritis pain: mechanisms of action of acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, and nerve growth factor antibodies.
    Postgraduate medicine, 2021, Volume: 133, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2021
NSAIDs are superior to paracetamol for osteoarthritic pain and function in a network meta-analysis.
    BMJ evidence-based medicine, 2018, Volume: 23, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Network Me

2018
Pharmacological Treatment of Pain in Osteoarthritis: A Descriptive Review.
    Current rheumatology reports, 2018, 11-21, Volume: 20, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2018
Safety of Paracetamol in Osteoarthritis: What Does the Literature Say?
    Drugs & aging, 2019, Volume: 36, Issue:Suppl 1

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthralgia; Chemical and Drug Induced Liver Injury; D

2019
Evidence-Based Recommendations on the Pharmacological Management of Osteoarthritis and Chronic Low Back Pain: An Asian Consensus
    Asian journal of anesthesiology, 2019, 06-01, Volume: 57, Issue:2

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidep

2019
The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: a systematic literature review and meta-analysis.
    BMC musculoskeletal disorders, 2014, Mar-11, Volume: 15

    Topics: Acetaminophen; Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bayes Theo

2014
Drugs for osteoarthritis.
    The Medical letter on drugs and therapeutics, 2014, Sep-01, Volume: 56, Issue:1450

    Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat

2014
Safety and efficacy of paracetamol and NSAIDs in osteoarthritis: which drug to recommend?
    Expert opinion on drug safety, 2015, Volume: 14, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2015
Controversy: hirudotherapy (leech therapy) as an alternative treatment for osteoarthritis.
    Acta medica Indonesiana, 2015, Volume: 47, Issue:2

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Complementary Therapies; Humans; Indon

2015
Safely Managing Acute Osteoarthritis in the Emergency Department: An Evidence-Based Review.
    The Journal of emergency medicine, 2016, Volume: 51, Issue:6

    Topics: Acetaminophen; Acute Disease; Administration, Cutaneous; Administration, Oral; Adrenal Cortex Hormon

2016
Move it or Lose it. Is it Reasonable for Older Adults with Osteoarthritis to Continue to Use Paracetamol in Order to Maintain Physical Activity?
    Drugs & aging, 2017, Volume: 34, Issue:6

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Exercise; Humans; Medication Adherence; Motor Activit

2017
Inflammation and shoulder pain--a perspective on rotator cuff disease, adhesive capsulitis, and osteoarthritis: conservative treatment.
    Clinical rheumatology, 2009, Volume: 28, Issue:5

    Topics: Acetaminophen; Administration, Oral; Adrenal Cortex Hormones; Analgesics, Opioid; Animals; Anti-Infl

2009
NSAIDs.
    BMJ clinical evidence, 2007, Jun-01, Volume: 2007

    Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Dose

2007
The role of acetaminophen in the treatment of osteoarthritis.
    The American journal of managed care, 2010, Volume: 16 Suppl Management

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents

2010
[Osteoarthritis - which approach is evidence based?].
    Praxis, 2010, Jul-07, Volume: 99, Issue:14

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Ulcer Agents; Antirheumatic Agents; Cyclooxygena

2010
Osteoarthritis: a review of treatment options.
    Geriatrics, 2009, Volume: 64, Issue:10

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2009
Outcome measures in placebo-controlled trials of osteoarthritis: responsiveness to treatment effects in the REPORT database.
    Osteoarthritis and cartilage, 2011, Volume: 19, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2011
Treatment options for osteoarthritis: considerations for older adults.
    Hospital practice (1995), 2011, Volume: 39, Issue:1

    Topics: Acetaminophen; Aged; Algorithms; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Stero

2011
NSAIDs.
    BMJ clinical evidence, 2010, Jun-28, Volume: 2010

    Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Huma

2010
The NSAID dilemma: managing osteoarthritis in high-risk patients.
    The Physician and sportsmedicine, 2011, Volume: 39, Issue:3

    Topics: Acetaminophen; Administration, Oral; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analge

2011
Pharmaceutical therapy for osteoarthritis.
    PM & R : the journal of injury, function, and rehabilitation, 2012, Volume: 4, Issue:5 Suppl

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 I

2012
[Antiinflammatory therapy in ostheoarthritis including omega 3 and omega 6 fatty acids].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2012, Volume: 32, Issue:191

    Topics: Acetaminophen; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin Sulfat

2012
Management of osteoarthritis of the knee.
    BMJ (Clinical research ed.), 2012, Jul-30, Volume: 345

    Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat

2012
Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioid analgesics.
    The American journal of geriatric pharmacotherapy, 2012, Volume: 10, Issue:6

    Topics: Acetaminophen; Age Factors; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Ag

2012
[Medication a complement to other forms of pain management in osteoarthritis].
    Lakartidningen, 2002, Nov-14, Volume: 99, Issue:46

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agen

2002
Pharmacologic therapy for osteoarthritis.
    American journal of orthopedics (Belle Mead, N.J.), 2002, Volume: 31, Issue:12

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dietary Supplemen

2002
New directions in symptomatic therapy for patients with osteoarthritis and rheumatoid arthritis.
    Seminars in arthritis and rheumatism, 2002, Volume: 32, Issue:3 Suppl 1

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase 2; Cyc

2002
Treating osteoarthritis pain.
    The Nurse practitioner, 2003, Volume: 28, Issue:4

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitor

2003
Acetaminophen for osteoarthritis.
    The Cochrane database of systematic reviews, 2003, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2003
[Paracetamol in the treatment of osteoarthritis pain].
    Drugs, 2003, Volume: 63 Spec No 2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg

2003
Translating research into practice: acetaminophen in osteoarthritis revisited.
    The Journal of rheumatology, 2004, Volume: 31, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Pain

2004
Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials.
    Annals of the rheumatic diseases, 2004, Volume: 63, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Patient Satisfaction; Randomized Co

2004
[Treatment for inflammation related pain--COX-2 inhibitors knocking on the door].
    Duodecim; laaketieteellinen aikakauskirja, 2004, Volume: 120, Issue:2

    Topics: Acetaminophen; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; Ibupr

2004
Clinical inquiries. Does acetaminophen and NSAID combined relieve osteoarthritis pain better than either alone?
    The Journal of family practice, 2004, Volume: 53, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Evidence-Based Me

2004
Acetaminophen as symptomatic treatment of pain from osteoarthritis.
    Joint bone spine, 2004, Volume: 71, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Controlled Clinica

2004
New developments in osteoarthritis.
    Clinics in geriatric medicine, 2005, Volume: 21, Issue:3

    Topics: Acetaminophen; Acupuncture Therapy; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non

2005
[Conservative therapy of arthritis].
    Der Orthopade, 2005, Volume: 34, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Chondr

2005
Symptomatic treatment of osteoarthritis: paracetamol or NSAIDs?
    International journal of clinical practice. Supplement, 2004, Issue:144

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2004
Osteoarthritis.
    The Journal of the Association of Physicians of India, 2005, Volume: 53

    Topics: Acetaminophen; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Bone Remodeling; Cartilage, Art

2005
The use of opioids in the treatment of osteoarthritis: when, why, and how?
    Current pain and headache reports, 2005, Volume: 9, Issue:6

    Topics: Acetaminophen; Acupuncture Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammator

2005
Acetaminophen for osteoarthritis.
    The Cochrane database of systematic reviews, 2006, Jan-25, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2006
Acetaminophen or NSAIDs for the treatment of osteoarthritis.
    Best practice & research. Clinical rheumatology, 2006, Volume: 20, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2006
Tramadol for osteoarthritis.
    The Cochrane database of systematic reviews, 2006, Jul-19, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Randomized Controlled Trials as Top

2006
Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease.
    Journal of the National Medical Association, 2006, Volume: 98, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Black or African A

2006
Pharmacotherapy of osteoarthritis.
    American journal of physical medicine & rehabilitation, 2006, Volume: 85, Issue:11 Suppl

    Topics: Acetaminophen; Administration, Topical; Analgesics; Anesthetics, Local; Capsaicin; Delayed-Action Pr

2006
Tramadol for osteoarthritis: a systematic review and metaanalysis.
    The Journal of rheumatology, 2007, Volume: 34, Issue:3

    Topics: Acetaminophen; Analgesics, Opioid; Drug Therapy, Combination; Humans; Osteoarthritis; Pain; Pain Mea

2007
COX-2 selective inhibitors in the treatment of osteoarthritis.
    Seminars in arthritis and rheumatism, 2008, Volume: 38, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cycl

2008
Treating the symptoms of osteoarthritis-oral treatments.
    Australian family physician, 2008, Volume: 37, Issue:3

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory

2008
Review of ibuprofen for osteoarthritis.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Toleran

1984
Practical management of osteoarthritis. Integration of pharmacologic and nonpharmacologic measures.
    Archives of family medicine, 1995, Volume: 4, Issue:12

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Codeine; Dext

1995
Should osteoarthritis be treated with nonsteroidal anti-inflammatory drugs?
    Rheumatic diseases clinics of North America, 1993, Volume: 19, Issue:3

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Drug Costs

1993
[Anti-inflammatory and analgesic treatment of osteoarthritis].
    La Revue du praticien, 1996, Mar-15, Volume: 46, Issue:6 Spec No

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Humans; In

1996
Use of carprofen for the treatment of pain and inflammation in dogs.
    Journal of the American Veterinary Medical Association, 1997, May-15, Volume: 210, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

1997
Non-NSAID pharmacologic treatment options for the management of chronic pain.
    The American journal of medicine, 1998, Jul-27, Volume: 105, Issue:1B

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1998
Osteoarthritis pain and its treatment.
    Current opinion in rheumatology, 2000, Volume: 12, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthro

2000
Role of intra-articular hyaluronic acid preparations in medical management of osteoarthritis of the knee.
    Seminars in arthritis and rheumatism, 2000, Volume: 30, Issue:2 Suppl 1

    Topics: Acetaminophen; Administration, Topical; Adrenal Cortex Hormones; Analgesics; Analgesics, Non-Narcoti

2000
Treatment of osteoarthritis with acetaminophen: efficacy, safety, and comparison with nonsteroidal anti-inflammatory drugs.
    Current rheumatology reports, 2000, Volume: 2, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Controlled Clinical Trials as Topic; Dose-Re

2000
Nonsteroidal anti-inflammatory drugs: overused or underused in osteoarthritis?
    The American journal of medicine, 2001, Jan-08, Volume: 110, Issue:1A

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Prescriptions

2001
The role of acetaminophen in the management of patients with osteoarthritis.
    The American journal of medicine, 2001, Feb-19, Volume: 110 Suppl 3A

    Topics: Acetaminophen; Activities of Daily Living; Age Distribution; Aged; Analgesics, Non-Narcotic; Anti-In

2001
Osteoarthritis management: the role of cyclooxygenase-2-selective inhibitors.
    Clinical therapeutics, 2001, Volume: 23, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor

2001
The role of analgesics in the management of osteoarthritis pain.
    American journal of therapeutics, 2000, Volume: 7, Issue:2

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Human

2000
Treatment of chronic pain in osteoarthritis: do opioids have a clinical role?
    Current rheumatology reports, 2001, Volume: 3, Issue:6

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Opioid-Related D

2001
Clinical evidence for osteoarthritis as an inflammatory disease.
    Current rheumatology reports, 2001, Volume: 3, Issue:6

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Combinations; Humans

2001
Osteoarthritis--a review.
    Journal of the Medical Association of Georgia, 2002,Winter, Volume: 91, Issue:1

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Exerci

2002
Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol).
    Current pharmaceutical design, 2002, Volume: 8, Issue:12

    Topics: Acetaminophen; Analgesia; Cardiovascular System; Celecoxib; Clinical Trials as Topic; Cyclooxygenase

2002
[Osteoarthritis. Pathogenesis, clinical features and treatment].
    Ugeskrift for laeger, 2002, Jun-10, Volume: 164, Issue:24

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cartilage,

2002
Ibuprofen. A review.
    The Practitioner, 1971, Volume: 207, Issue:241

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials

1971

Trials

60 trials available for acetaminophen and Osteoarthritis

ArticleYear
Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up.
    Clinics (Sao Paulo, Brazil), 2022, Volume: 77

    Topics: Acetaminophen; Double-Blind Method; Female; Follow-Up Studies; Humans; Injections, Intra-Articular;

2022
A cluster randomized trial to measure the impact on nonsteroidal anti-inflammatory drug and proton pump inhibitor prescribing in Italy of distributing cost-free paracetamol to osteoarthritic patients.
    BMC family practice, 2019, 12-06, Volume: 20, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster

2019
Effect of effervescent paracetamol on blood pressure: a crossover randomized clinical trial.
    Journal of hypertension, 2018, Volume: 36, Issue:8

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Antihypertensive Agents; Blood Pressure; Blood Pressu

2018
Patient preferences for adherence to treatment for osteoarthritis: the MEdication Decisions in Osteoarthritis Study (MEDOS).
    BMC musculoskeletal disorders, 2013, May-06, Volume: 14

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Choice Behavior; Female; Glucosa

2013
Interaction between antihypertensives and NSAIDs in primary care: a controlled trial.
    The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2008,Fall, Volume: 15, Issue:3

    Topics: Acetaminophen; Aged; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; B

2008
A randomized, multicentric, comparative evaluation of aceclofenac-paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up.
    Expert opinion on pharmacotherapy, 2009, Volume: 10, Issue:5

    Topics: Acetaminophen; Adult; Aged; Diclofenac; Drug Therapy, Combination; Female; Humans; India; Male; Midd

2009
Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study.
    Clinical drug investigation, 2009, Volume: 29 Suppl 1

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid;

2009
Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial.
    Arthritis research & therapy, 2009, Volume: 11, Issue:6

    Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dietary Supplements

2009
Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain.
    Postgraduate medicine, 2010, Volume: 122, Issue:4

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chronic Diseas

2010
[Merits of paracetamol in osteoarthritic hypertensive patients].
    Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 2011, Volume: 65, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Antihypertensive Agents; Blood Pre

2011
No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2011, Volume: 112, Issue:6

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Double-Blind Method; Facial Pain; Fem

2011
A randomized, 14-day, double-blind study evaluating conversion from hydrocodone/acetaminophen (Vicodin) to buprenorphine transdermal system 10 μg/h or 20 μg/h in patients with osteoarthritis pain.
    Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:9

    Topics: Acetaminophen; Administration, Cutaneous; Administration, Oral; Aged; Analgesics, Opioid; Anti-Infla

2012
Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial.
    The Journal of rheumatology, 2004, Volume: 31, Issue:1

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors;

2004
Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:3

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste

2004
Continuous low-level heat wrap therapy is effective for treating wrist pain.
    Archives of physical medicine and rehabilitation, 2004, Volume: 85, Issue:9

    Topics: Acetaminophen; Activities of Daily Living; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bandag

2004
Trial of tramadol/acetaminophen tablets for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug.
    The Journal of rheumatology, 2005, Volume: 32, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2005
Using n-of-1 trials as a clinical tool to improve prescribing.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2005, Volume: 55, Issue:512

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hy

2005
Impact of a general practitioner educational intervention on osteoarthritis treatment in an elderly population.
    The American journal of medicine, 2005, Volume: 118, Issue:11

    Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents;

2005
Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials.
    Rheumatology (Oxford, England), 2007, Volume: 46, Issue:1

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N

2007
Three-month efficacy and safety of acetaminophen extended-release for osteoarthritis pain of the hip or knee: a randomized, double-blind, placebo-controlled study.
    Osteoarthritis and cartilage, 2007, Volume: 15, Issue:4

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Double-Blind Method; Female

2007
Transcutaneous electrical nerve stimulation in osteoarthrosis: a therapeutic alternative?
    Annals of the rheumatic diseases, 1984, Volume: 43, Issue:1

    Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Electric Stimulation Ther

1984
Review of ibuprofen for osteoarthritis.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Toleran

1984
Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis.
    Current medical research and opinion, 1983, Volume: 8, Issue:8

    Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Combinations; Humans; Metoclopr

1983
A comparison of three ways of measuring pain.
    Rheumatology and rehabilitation, 1982, Volume: 21, Issue:4

    Topics: Acetaminophen; Aged; Apazone; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomet

1982
An articular index for the assessment of osteoarthritis.
    Annals of the rheumatic diseases, 1981, Volume: 40, Issue:1

    Topics: Acetaminophen; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Method; Drug Combinations;

1981
Analgesic properties of fluproquazone.
    Rheumatology and rehabilitation, 1982, Volume: 21, Issue:2

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Dextropropo

1982
Histological study of the effects of three anti-inflammatory preparations on the gastric mucosa.
    Journal of clinical pathology, 1981, Volume: 34, Issue:8

    Topics: Acetaminophen; Acute Disease; Adult; Anti-Inflammatory Agents; Chronic Disease; Dextropropoxyphene;

1981
Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis.
    European journal of rheumatology and inflammation, 1994, Volume: 14, Issue:2

    Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relat

1994
Intra-articular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy.
    Annals of the rheumatic diseases, 1994, Volume: 53, Issue:8

    Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug

1994
n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis.
    BMJ (Clinical research ed.), 1994, Oct-22, Volume: 309, Issue:6961

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesia; Capsules; Diclofenac; Double-Blind Method;

1994
The effect of folate and cobalamin on osteoarthritic hands.
    Journal of the American College of Nutrition, 1994, Volume: 13, Issue:4

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Double-Blind Method; Fol

1994
Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee.
    Arthritis and rheumatism, 1993, Volume: 36, Issue:9

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Arthrography; Double-Blind Method; Female; Humans; Kn

1993
Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis.
    The Journal of rheumatology, 1996, Volume: 23, Issue:8

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin

1996
Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis.
    The Journal of rheumatology, 1996, Volume: 23, Issue:8

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin

1996
Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis.
    The Journal of rheumatology, 1996, Volume: 23, Issue:8

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin

1996
Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis.
    The Journal of rheumatology, 1996, Volume: 23, Issue:8

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin

1996
[Analgesic effect and clinical tolerability of the combination of paracetamol 500 mg and caffeine 50 mg versus paracetamol 400 mg and dextropropoxyphene 30 mg in back pain].
    Presse medicale (Paris, France : 1983), 1996, Sep-07, Volume: 25, Issue:25

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Back Pa

1996
Floctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs. Franco-Belgian Task Force.
    Revue du rhumatisme (English ed.), 1997, Volume: 64, Issue:5

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross

1997
Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial.
    The Journal of rheumatology, 1999, Volume: 26, Issue:4

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-In

1999
Preliminary experiences with a single-patient trials service in general practice.
    The Medical journal of Australia, 2000, Jul-17, Volume: 173, Issue:2

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N

2000
[Postoperative pain and surgical treatment of trapeziometacarpal osteoarthritis of the thumb after ambulatory surgery].
    Annales francaises d'anesthesie et de reanimation, 2000, Volume: 19, Issue:9

    Topics: Acetaminophen; Aged; Ambulatory Surgical Procedures; Analgesics; Anti-Inflammatory Agents, Non-Stero

2000
Educational program for physicians to reduce use of non-steroidal anti-inflammatory drugs among community-dwelling elderly persons: a randomized controlled trial.
    Medical care, 2001, Volume: 39, Issue:5

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Utilization; Education, Medical,

2001
Educational program for nursing home physicians and staff to reduce use of non-steroidal anti-inflammatory drugs among nursing home residents: a randomized controlled trial.
    Medical care, 2001, Volume: 39, Issue:5

    Topics: Acetaminophen; Aged; Aged, 80 and over; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Decisio

2001
Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study.
    Clinical therapeutics, 2002, Volume: 24, Issue:2

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Respon

2002
Comparative study of salsalate and aspirin in osteoarthrosis of the hip or knee.
    Current medical research and opinion, 1978, Volume: 5, Issue:6

    Topics: Acetaminophen; Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation;

1978
Successful use of a moderate analgesic (Fortagesic) in the symptomatic treatment of osteoarthritis.
    The Journal of international medical research, 1979, Volume: 7, Issue:1

    Topics: Acetaminophen; Drug Combinations; Female; Humans; Male; Naproxen; Osteoarthritis; Pentazocine

1979
A clinical Trial of Tofranil in osteo-arthritis.
    The Journal of international medical research, 1976, Volume: 4, Issue:2 Suppl

    Topics: Acetaminophen; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; Imipram

1976
A trial of Fortagesic and Paramol 118 in osteoarthritis.
    The Journal of international medical research, 1976, Volume: 4, Issue:6

    Topics: Acetaminophen; Codeine; Drug Combinations; Humans; Osteoarthritis; Pentazocine

1976
Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic.
    The Journal of rheumatology, 1992, Volume: 19, Issue:12

    Topics: Acetaminophen; Adult; Aged; Analysis of Variance; Dose-Response Relationship, Drug; Double-Blind Met

1992
Acceptability and efficacy of two associations of paracetamol with a central analgesic (dextropropoxyphene or codeine): comparison in osteoarthritis.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:11

    Topics: Acetaminophen; Aged; Capsules; Codeine; Dextropropoxyphene; Double-Blind Method; Drug Combinations;

1992
Comparative clinical evaluation of the activity of Ser-316 suppository in the treatment of lumbar osteoarthrosis.
    Current medical research and opinion, 1991, Volume: 12, Issue:7

    Topics: Acetaminophen; Activities of Daily Living; Double-Blind Method; Female; Follow-Up Studies; Humans; I

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
    The New England journal of medicine, 1991, Jul-11, Volume: 325, Issue:2

    Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti

1991
Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study.
    Pain, 1990, Volume: 43, Issue:3

    Topics: Acetaminophen; Aged; Chronic Disease; Codeine; Double-Blind Method; Drug Combinations; Hip Joint; Hu

1990
A method for comparing analgesics: glafenine and paracetamol. Multicenter cross-over approach.
    Clinical rheumatology, 1988, Volume: 7, Issue:4

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Double-Blind Method; Glafenine; Hip Joint; Humans; Kn

1988
Comparison of a standard ibuprofen treatment regimen with a new ibuprofen/paracetamol/codeine combination in chronic osteo-arthritis.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1987, Oct-17, Volume: Suppl

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Codeine; Double-Blind Metho

1987
[Treatment of the diseases of the extended rheumatic sphere form with paracetamol (Dolo-arthrosetten)].
    Munchener medizinische Wochenschrift (1950), 1973, Oct-19, Volume: 115, Issue:42

    Topics: Acetaminophen; Anti-Inflammatory Agents; Back Pain; Cartilage Diseases; Drug Therapy, Combination; H

1973
Fenoprofen in the treatment of osteoarthrosis.
    Current medical research and opinion, 1974, Volume: 2, Issue:9

    Topics: Acetaminophen; Anti-Inflammatory Agents; Humans; Osteoarthritis; Pain; Phenyl Ethers; Phenylbutazone

1974
'Safapryn' and benorylate--a comparative trial of two new preparations of aspirin and paracetamol in the treatment of rheumatoid arthritis and osteoarthritis.
    Current medical research and opinion, 1973, Volume: 1, Issue:9

    Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Combinations; Drug Eva

1973
Fenoprofen in treatment of osteoarthrosis of hip and knee.
    British medical journal, 1974, Jun-01, Volume: 2, Issue:5917

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Clinical Trials as Topic; Drug Evaluation; Fema

1974
Orudis in the management of osteo-arthritis of the knee. A double-blind trial.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974, Jul-27, Volume: 48, Issue:36

    Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic;

1974
The analgesic properties of chlorphenesin carbamate in the treatment of osteoarthrosis. Report of a trial.
    Annals of physical medicine, 1968, Volume: 9, Issue:5

    Topics: Acetaminophen; Aged; Analgesics; Chlorphenesin; Clinical Trials as Topic; Female; Hip Joint; Humans;

1968
Ibuprofen. A review.
    The Practitioner, 1971, Volume: 207, Issue:241

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials

1971
An assessment of "Fiorinal" and FIPA in painful conditions of the hands.
    The Medical journal of Australia, 1970, Aug-15, Volume: 2, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics; Analysis of Variance; Arthritis, Rheumatoid; Aspirin; Caffei

1970

Other Studies

96 other studies available for acetaminophen and Osteoarthritis

ArticleYear
Paracetamol Use in Patients With Osteoarthritis and Lower Back Pain: Infodemiology Study and Observational Analysis of Electronic Medical Record Data.
    JMIR public health and surveillance, 2022, 10-27, Volume: 8, Issue:10

    Topics: Acetaminophen; Adult; Electronic Health Records; Female; Humans; Infodemiology; Low Back Pain; Male;

2022
Why are we still using opioids for osteoarthritis?
    International journal of clinical practice, 2020, Volume: 74, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2020
Osteoarthritis in Older Adults: Nonsteroidal Anti-Inflammatory Drugs Versus Opioids.
    The Senior care pharmacist, 2019, Dec-01, Volume: 34, Issue:10

    Topics: Acetaminophen; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2019
Drugs for osteoarthritis.
    The Medical letter on drugs and therapeutics, 2020, Apr-20, Volume: 62, Issue:1596

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Duloxetine Hydrochloride

2020
Initial analgesic prescriptions for osteoarthritis in the United Kingdom, 2000-2016.
    Rheumatology (Oxford, England), 2021, 01-05, Volume: 60, Issue:1

    Topics: Acetaminophen; Administration, Cutaneous; Administration, Oral; Aged; Analgesics; Analgesics, Opioid

2021
Nonsteroidal Antiinflammatory Drugs and Susceptibility to COVID-19.
    Arthritis & rheumatology (Hoboken, N.J.), 2021, Volume: 73, Issue:5

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal;

2021
Naproxen treatment inhibits articular cartilage loss in a rat model of osteoarthritis.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2021, Volume: 39, Issue:10

    Topics: Acetaminophen; Animals; Cartilage, Articular; Disease Models, Animal; Female; Naproxen; Osteoarthrit

2021
Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis.
    BMJ open, 2021, 08-11, Volume: 11, Issue:8

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Meta-Analysis as Topic; Osteoarthrit

2021
Regular use of acetaminophen or acetaminophen-codeine combinations and prescription of rescue therapy with non-steroidal anti-inflammatory drugs: a population-based study in primary care.
    Current medical research and opinion, 2017, Volume: 33, Issue:6

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Coh

2017
Prevalence and changes in analgesic medication utilisation 1 year prior to total joint replacement in an older cohort of patients.
    Osteoarthritis and cartilage, 2018, Volume: 26, Issue:3

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, No

2018
Analgesic Use and Risk for Acute Coronary Events in Patients With Osteoarthritis: A Population-based, Nested Case-control Study.
    Clinical therapeutics, 2018, Volume: 40, Issue:2

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Angina, Unstable; Ant

2018
Analgesic prescribing trends in a national sample of older veterans with osteoarthritis: 2012-2017.
    Pain, 2019, Volume: 160, Issue:6

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Age

2019
Increasing Participation in Daily Activities among US Adults with Arthritis.
    American journal of health behavior, 2019, 05-01, Volume: 43, Issue:3

    Topics: Acetaminophen; Activities of Daily Living; Aged; Analgesics, Non-Narcotic; Arthralgia; Exercise; Fem

2019
Analgesics for osteoarthritis.
    American family physician, 2013, Mar-01, Volume: 87, Issue:5

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Gastroi

2013
Pharmacologic treatment of hand-, knee- and hip-osteoarthritis.
    Wiener medizinische Wochenschrift (1946), 2013, Volume: 163, Issue:9-10

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adrenal Cortex Hormones; Analgesics; A

2013
Managing osteoarthritis pain in the older population.
    Journal of pain & palliative care pharmacotherapy, 2013, Volume: 27, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Age Factors; Aged; Aging; Analgesics,

2013
The therapeutic management of chronic pain in ambulatory care patients aged 65 and over in France: the S.AGES Cohort. Baseline data.
    The journal of nutrition, health & aging, 2013, Volume: 17, Issue:8

    Topics: Acetaminophen; Aged; Aged, 80 and over; Ambulatory Care; Analgesics; Back Pain; Chronic Pain; Dextro

2013
How safe is acetaminophen in rheumatology?
    Joint bone spine, 2014, Volume: 81, Issue:1

    Topics: Acetaminophen; Cardiovascular Diseases; Chronic Pain; Humans; Musculoskeletal Pain; Osteoarthritis;

2014
NICE keeps paracetamol in UK guidelines on osteoarthritis.
    BMJ (Clinical research ed.), 2014, Feb-13, Volume: 348

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Practice Guidelines as Topic; Unite

2014
Exercise stays central to treatment of osteoarthritis in latest advice.
    Nursing older people, 2014, Volume: 26, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Exercise; Humans; Osteoarthritis; Practice Guidelines as To

2014
Pilot open observations on doxycycline treatment for erosive osteoarthritis of the hand.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2015, Volume: 21, Issue:1

    Topics: Acetaminophen; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Doxycycli

2015
Managing back pain and osteoarthritis without paracetamol.
    BMJ (Clinical research ed.), 2015, Mar-31, Volume: 350

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Back Pain; Humans; Osteoarthritis

2015
Study findings on acetaminophen at odds with clinical guidelines.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2015, Jun-01, Volume: 72, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Osteoarthritis; Practice Guidelines

2015
Response to: 'Paracetamol: is all the concern valid?' by Schwarz and Mullins.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2015
NSAIDs or paracetamol for short-term treatment of mild to moderate knee pain in early osteoarthritis: are they equivalent?
    Evidence-based medicine, 2016, Volume: 21, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr

2016
Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study.
    Pharmacotherapy, 2015, Volume: 35, Issue:10

    Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Dise

2015
Have osteoarthritis? Careful with narcotic painkillers.
    Harvard men's health watch, 2013, Volume: 17, Issue:10

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Humans; Narcotics; Osteoarthritis

2013
Prescription usage patterns of two formulations of paracetamol in osteoarthritis: Australia-wide experience 2008-11.
    Australian family physician, 2016, Volume: 45, Issue:5

    Topics: Acetaminophen; Aged; Aged, 80 and over; Australia; Delayed-Action Preparations; Drug Compounding; Fe

2016
Satisfaction, Adherence and Health-Related Quality of Life with Transdermal Buprenorphine Compared with Oral Opioid Medications in the Usual Care of Osteoarthritis Pain.
    The patient, 2016, Volume: 9, Issue:4

    Topics: Acetaminophen; Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Anal

2016
Acetaminophen in Perspective.
    Journal of the American Geriatrics Society, 2016, Volume: 64, Issue:11

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthralgia; Female; Humans; Male; Osteoarthritis; Tre

2016
Managing back pain and osteoarthritis without paracetamol: Physical treatments are the way forward.
    British journal of sports medicine, 2016, Volume: 50, Issue:20

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Back Pain; Humans; Osteoarthritis; Pain Management

2016
Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis?
    International journal of rheumatic diseases, 2018, Volume: 21, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antirheumatic Agents; Biomarkers; Cartilage Oligomeric Matr

2018
GP management of osteoarthritic pain in Hong Kong.
    Australian family physician, 2008, Volume: 37, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Sectional St

2008
Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market.
    Clinical rheumatology, 2009, Volume: 28, Issue:5

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N

2009
Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market.
    Clinical rheumatology, 2009, Volume: 28, Issue:5

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N

2009
Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market.
    Clinical rheumatology, 2009, Volume: 28, Issue:5

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N

2009
Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market.
    Clinical rheumatology, 2009, Volume: 28, Issue:5

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N

2009
Use of recommended osteoarthritis pain treatment by older adults.
    Journal of advanced nursing, 2009, Volume: 65, Issue:4

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster

2009
Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis.
    European journal of pharmacology, 2009, Jun-24, Volume: 613, Issue:1-3

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dis

2009
Blood pressure destabilization on nonsteroidal antiinflammatory agents: acetaminophen exposed?
    Circulation, 2010, Nov-02, Volume: 122, Issue:18

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiovascular Diseases; Dos

2010
"It looks after me": how older patients make decisions about analgesics for osteoarthritis.
    Arthritis care & research, 2011, Volume: 63, Issue:9

    Topics: Acetaminophen; Age Factors; Aged; Aged, 80 and over; Aging; Analgesics, Non-Narcotic; Anti-Inflammat

2011
Flavocoxid inhibits phospholipase A2, peroxidase moieties of the cyclooxygenases (COX), and 5-lipoxygenase, modifies COX-2 gene expression, and acts as an antioxidant.
    Mediators of inflammation, 2011, Volume: 2011

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonate 5-Lipoxy

2011
Therapy switching, augmentation, and discontinuation in patients with osteoarthritis and chronic low back pain.
    Pain practice : the official journal of World Institute of Pain, 2012, Volume: 12, Issue:6

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-In

2012
Older adult osteoarthritis pain management: results from the 2008 National Ambulatory Medical Care Survey.
    Journal of the American Academy of Nurse Practitioners, 2012, Volume: 24, Issue:2

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Combined Modality Therapy; Comorbidity

2012
Older adults living with osteoarthritis: examining the relationship of age and gender to medicine use.
    Canadian journal on aging = La revue canadienne du vieillissement, 2012, Volume: 31, Issue:3

    Topics: Acetaminophen; Age Factors; Aged; Analgesics, Opioid; Analysis of Variance; Anti-Inflammatory Agents

2012
Factors predicting older adults' use of exercise and acetaminophen for osteoarthritis pain.
    Journal of the American Academy of Nurse Practitioners, 2012, Volume: 24, Issue:11

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Case-Control

2012
Effect of acetaminophen and nonsteroidal anti-inflammatory drugs on gene expression of mesenchymal stem cells.
    Tissue engineering. Part A, 2013, Volume: 19, Issue:7-8

    Topics: Acetaminophen; Aged; Aged, 80 and over; Aggrecans; Alkaline Phosphatase; Anti-Inflammatory Agents, N

2013
Key questions concerning paracetamol and NSAIDs for osteoarthritis.
    Annals of the rheumatic diseases, 2002, Volume: 61, Issue:9

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Analgesics, Non-Narcotic; Anti-Inflamm

2002
Et tu, acetaminophen?
    Arthritis and rheumatism, 2002, Volume: 46, Issue:11

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygena

2002
Published meta-analyses of pharmacological therapies for osteoarthritis.
    Osteoarthritis and cartilage, 2002, Volume: 10, Issue:11

    Topics: Acetaminophen; Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chondroi

2002
Key questions concerning paracetamol and NSAIDs for OA.
    Annals of the rheumatic diseases, 2003, Volume: 62, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; I

2003
DEGENERATIVE JOINT DISEASES--DISCS AND OSTEOARTHRITIS. II. DIAGNOSIS AND MANAGEMENT OF OSTEOARTHRITIS.
    The Journal of the College of General Practitioners, 1963, Volume: 6

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Diagnosis, Differential;

1963
Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis.
    The Journal of rheumatology, 2003, Volume: 30, Issue:10

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dose-R

2003
Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis.
    Osteoarthritis and cartilage, 2003, Volume: 11, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis

2003
Serious gastrointestinal events from low dose analgesic use.
    The Journal of rheumatology, 2004, Volume: 31, Issue:5

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dose-Respons

2004
A 64 year old woman with knee pain: case outcome.
    BMJ (Clinical research ed.), 2004, Jul-03, Volume: 329, Issue:7456

    Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Decision Making; Drug Interactions; Femal

2004
A historic issue of the Annals: three papers examine paracetamol in osteoarthritis.
    Annals of the rheumatic diseases, 2004, Volume: 63, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Randomized Controlled Trials as Top

2004
NSAID alternatives.
    The Medical letter on drugs and therapeutics, 2005, Jan-17, Volume: 47, Issue:1200

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase Inhibi

2005
Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:1

    Topics: Acetaminophen; Age Factors; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Human

2005
Acetaminophen may act through beta endorphin.
    Annals of the rheumatic diseases, 2005, Volume: 64, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; beta-Endorphin; Humans; Osteoarthritis

2005
Opioids for non-operable osteoarthritis and soft-tissue rheumatism.
    Arthritis research & therapy, 2005, Volume: 7, Issue:5

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents,

2005
Australia: the N of 1 trial, an underappreciated research method.
    Family medicine, 2006, Volume: 38, Issue:1

    Topics: Acetaminophen; Aged; Attention Deficit Disorder with Hyperactivity; Australia; Child; Child, Prescho

2006
Paracetamol should be first-line therapy in osteoarthritis.
    The Medical journal of Australia, 2005, Feb-21, Volume: 182, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Practice Guidelines as Topic; Treat

2005
The effect of cyclooxygenase-2 inhibitors on bone mineral density: results from the Canadian Multicentre Osteoporosis Study.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2006, Volume: 17, Issue:9

    Topics: Acetaminophen; Adult; Aged; Body Mass Index; Bone Density; Cyclooxygenase 2 Inhibitors; Dose-Respons

2006
NSAIDs better than acetaminophen for mild-to-moderate OA pain.
    Health news (Waltham, Mass.), 2006, Volume: 12, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Humans

2006
Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.
    Calcified tissue international, 2006, Volume: 79, Issue:2

    Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin;

2006
Conducting research in individual patients: lessons learnt from two series of N-of-1 trials.
    BMC family practice, 2006, Sep-19, Volume: 7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Rela

2006
Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials.
    Current medical research and opinion, 2006, Volume: 22, Issue:11

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Analgesics, Non-Narcotic; Aspar

2006
Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials.
    Current medical research and opinion, 2006, Volume: 22, Issue:11

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Analgesics, Non-Narcotic; Aspar

2006
Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials.
    Current medical research and opinion, 2006, Volume: 22, Issue:11

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Analgesics, Non-Narcotic; Aspar

2006
Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials.
    Current medical research and opinion, 2006, Volume: 22, Issue:11

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Analgesics, Non-Narcotic; Aspar

2006
Advice for nurses on drug withdrawal.
    Australian nursing journal (July 1993), 2007, Volume: 15, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Australia; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Ap

2007
Pain and inflammation.
    The American journal of medicine, 1984, Sep-10, Volume: 77, Issue:3A

    Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Humans; Osteoarthritis; Pai

1984
Further look at dextropropoxyphene with or without paracetamol in the treatment of arthritis.
    The Medical journal of Australia, 1984, Feb-18, Volume: 140, Issue:4

    Topics: Acetaminophen; Arthritis, Rheumatoid; Dextropropoxyphene; Double-Blind Method; Drug Combinations; Dr

1984
n of 1 trials in osteoarthritis. Study was conceptually and statistically biased.
    BMJ (Clinical research ed.), 1995, Mar-11, Volume: 310, Issue:6980

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Bias; Humans; Osteoarthritis; Randomized Con

1995
n of 1 trials in osteoarthritis. Caution in interpretation needed.
    BMJ (Clinical research ed.), 1995, Mar-11, Volume: 310, Issue:6980

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Data Interpretation, Statistical; Humans; Os

1995
Treatment for non-inflammatory arthritis.
    Lancet (London, England), 1994, Jun-04, Volume: 343, Issue:8910

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis

1994
Simple analgesics versus NSAIDs for osteoarthritis.
    Lancet (London, England), 1993, Mar-20, Volume: 341, Issue:8847

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Treatment Outcome

1993
Osteoarthritis treatment update. Minimizing pain while limiting patient risk.
    Postgraduate medicine, 1993, Volume: 93, Issue:1

    Topics: Acetaminophen; Administration, Topical; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Stero

1993
Osteoarthritis: new roles for drug therapy and surgery. Interview by Peter Pompei.
    Geriatrics, 1996, Volume: 51, Issue:9

    Topics: Acetaminophen; Activities of Daily Living; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents,

1996
North of England evidence based guideline development project: summary guideline for non-steroidal anti-inflammatory drugs versus basic analgesia in treating the pain of degenerative arthritis. The North of England Non-Steroidal Anti-Inflammatory Drug Gui
    BMJ (Clinical research ed.), 1998, Aug-22, Volume: 317, Issue:7157

    Topics: Acetaminophen; Activities of Daily Living; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Codei

1998
When joints--and costs--become inflamed.
    Business and health, 1997, Volume: 15, Issue:12

    Topics: Acetaminophen; Adrenal Cortex Hormones; Arthroplasty, Replacement; Cost of Illness; Health Care Cost

1997
Preference for nonsteroidal antiinflammatory drugs over acetaminophen by rheumatic disease patients: a survey of 1,799 patients with osteoarthritis, rheumatoid arthritis, and fibromyalgia.
    Arthritis and rheumatism, 2000, Volume: 43, Issue:2

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Fibromy

2000
Preference for nonsteroidal antiinflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis.
    The Journal of rheumatology, 2000, Volume: 27, Issue:4

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Data Collect

2000
Tempering the enthusiasm for COX-2 inhibitors.
    American family physician, 2000, Jun-15, Volume: 61, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cycloox

2000
Economic evaluation alongside n-of-1 trials: getting closer to the margin.
    Health economics, 2001, Volume: 10, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; C

2001
Treatment of osteoarthritic pain: systemic drug therapy is not always necessary.
    Prescrire international, 2000, Volume: 9, Issue:50

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Human

2000
Quality indicators for the management of osteoarthritis in vulnerable elders.
    Annals of internal medicine, 2001, Oct-16, Volume: 135, Issue:8 Pt 2

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste

2001
Rofecoxib vs celecoxib vs acetaminophen for treatment of osteoarthritis.
    JAMA, 2002, Apr-10, Volume: 287, Issue:14

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cycloox

2002
Rofecoxib vs celecoxib vs acetaminophen for treatment of osteoarthritis.
    JAMA, 2002, Apr-10, Volume: 287, Issue:14

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cycloox

2002
Trends in medication use for osteoarthritis treatment.
    The Journal of rheumatology, 2002, Volume: 29, Issue:5

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Drug Utilization;

2002
The absorption of Safapryn in patients with arthritis.
    The British journal of clinical practice, 1976, Volume: 30, Issue:4

    Topics: Acetaminophen; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Drug Combinations; Female; Humans; Intes

1976
Treatment options for a patient with osteoarthritis and a history of ulcer disease.
    Clinical pharmacy, 1991, Volume: 10, Issue:10

    Topics: Acetaminophen; Administration, Oral; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Comb

1991
Medical therapy of osteoarthritis of the knee.
    The New England journal of medicine, 1991, Dec-19, Volume: 325, Issue:25

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Humans; Knee Joint; Osteoarthritis

1991
Cartilage degradative enzymes in human osteoarthritis: effect of a nonsteroidal antiinflammatory drug administered orally.
    Seminars in arthritis and rheumatism, 1990, Volume: 19, Issue:4 Suppl 1

    Topics: Acetaminophen; Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Artic

1990
Simple analgesics preferable to NSAIDs for the elderly.
    Irish medical journal, 1990, Volume: 83, Issue:2

    Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Pa

1990
Controlled-release ketoprofen in rheumatoid arthritis and osteoarthritis: comparison of two doses in Thailand.
    Clinical therapeutics, 1988, Volume: 10, Issue:3

    Topics: Acetaminophen; Adult; Aged; Arthritis, Rheumatoid; Delayed-Action Preparations; Female; Humans; Keto

1988
Osteoarthritis: increasing mobility and reducing disability.
    Geriatrics, 1986, Volume: 41, Issue:2

    Topics: Acetaminophen; Adrenal Cortex Hormones; Aged; Ankle Joint; Anti-Inflammatory Agents; Aspirin; Cervic

1986
Aspirin and the kidney. New Zealand Rheumatism Association Study.
    British medical journal, 1974, Mar-30, Volume: 1, Issue:5908

    Topics: Acetaminophen; Adult; Arthritis, Rheumatoid; Aspirin; Caffeine; Codeine; Drug Synergism; Female; Hum

1974
[The association of paracetamol and phenylbutazone in rheumatology. Preliminary report].
    Hospital (Rio de Janeiro, Brazil), 1966, Volume: 70, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child; Female; Fibromyalgia; Humans;

1966
Comparison of flufenamic acid with aspirin and paracetamol in terms of gastrointestinal blood loss.
    Annals of physical medicine, 1966, Volume: Suppl

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chromium Isotopes; Fe

1966
[On the two-phase therapy of degenerative rheumatism with a myotonolytic-antiphlogistic and an analgesic combination preparation].
    Praxis, 1968, Aug-27, Volume: 57, Issue:34

    Topics: Acetaminophen; Adult; Aged; Benzoxazoles; Chlorzoxazone; Female; Humans; Male; Middle Aged; Muscles;

1968