acetaminophen has been researched along with Osteoarthritis in 228 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The following variables were assessed: articular pain and swelling, AUSCAN and COCHIN functional questionnaires, grip and pinch strength, goniometry, perception of improvement, acetaminophen consumption, and simple radiography." | 9.51 | Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up. ( Fernandes, ADRC; Furtado, RNV; Machado, FS; Natour, J; Oliveira, HAV; Paschoal, NOS, 2022) |
| "Insured patients with a history of osteoarthritis or back pain and receiving ibuprofen, other ns-NSAIDs, COX-2i or paracetamol between 1 November, 2019 and 31 January, 2020 (study enrolment window 1) or between 1 February, 2020 and 31 October, 2020 (study enrolment window 2)." | 9.41 | Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study. ( Argyriou, G; Brash, JT; Driessen, S; Prieto-Alhambra, D; Reich, C; Seager, S; Turkmen, C; Varrassi, G; Xie, J, 2023) |
| "The aim of this study was to evaluate the clinical effects of oral glucosamine sulfate, compared with placebo, on osteoarthritis in the temporomandibular joints (TMJs)." | 9.15 | No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study. ( Cahlin, BJ; Dahlström, L, 2011) |
| "To evaluate efficacy and safety of aceclofenac-paracetamol combination against aceclofenac alone in patients with osteoarthritis (OA) flare-up." | 9.14 | A randomized, multicentric, comparative evaluation of aceclofenac-paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up. ( Bartakke, G; Chandurkar, N; Desai, M; Kini, S; Pareek, A; Sharma, VD, 2009) |
| "To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)." | 9.14 | Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009) |
| "To assess the efficacy and safety of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA; MS-sNT), which contain morphine sulfate pellets with a sequestered naltrexone core, in treating patients with chronic, moderate-to-severe osteoarthritis (hip or knee) pain." | 9.14 | Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain. ( Hale, M; Katz, N; Morris, D; Stauffer, J, 2010) |
| "To assess the use of n-of-1 trials for short-term choice of drugs for osteoarthritis, with particular reference to comparing the efficacy of sustained-release [SR] paracetamol with celecoxib in individual patients." | 9.12 | Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials. ( Brown, RM; Del Mar, CB; McNairn, N; Nikles, CJ; Schluter, PJ; Yelland, MJ, 2007) |
| "To examine the efficacy and safety of two doses of long-acting acetaminophen in patients with osteoarthritis (OA) of the hip or knee." | 9.12 | Three-month efficacy and safety of acetaminophen extended-release for osteoarthritis pain of the hip or knee: a randomized, double-blind, placebo-controlled study. ( Altman, RD; Schweinle, JE; Temple, AR; Zinsenheim, JR, 2007) |
| "5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) as add-on therapy for subjects with osteoarthritis (OA) pain inadequately controlled by COX-2 nonsteroidal antiinflammatory drugs (NSAID)." | 9.11 | Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. ( Emkey, R; Jordan, D; Kamin, M; Rosenthal, N; Wu, SC, 2004) |
| "5 mg/acetaminophen (APAP) 325 mg combination tablets (tramadol/APAP) to existing therapy for painful osteoarthritis (OA) flare in a subset of elderly patients." | 9.11 | Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population. ( Jordan, D; Kamin, M; Rosenthal, NR; Silverfield, JC; Wu, SC, 2004) |
| "The addition of tramadol/acetaminophen tablets to existing therapy was compared with the addition of placebo in the treatment of OA flare pain." | 9.10 | Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. ( Kamin, M; Rosenthal, N; Silverfield, JC; Wu, SC, 2002) |
| "To compare the efficacy and safety of controlled release oxycodone given every 12 h around the clock with immediate release oxycodone-acetaminophen (APAP) given 4 times daily for osteoarthritis (OA) pain." | 9.09 | Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial. ( Boyd, RE; Caldwell, JR; Hague, JM; Hale, ME; Iwan, T; Lacouture, PG; Shi, M, 1999) |
| "To assess the clinical efficacy of chondroitin sulfate (CS) in comparison with the nonsteroidal antiinflammatory drug (NSAID) diclofenac sodium (DS) in a medium/longterm clinical study in patients with knee osteoarthritis (OA)." | 9.08 | Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. ( Boccanera, L; Bocchi, L; Galati, M; Manopulo, R; Morreale, P; Saponati, G, 1996) |
| "A multicenter, double-blind, cross-over, random-order study compared the efficacy of floctafenin, 800 mg/day and acetaminophen, 3000 mg/day, in providing pain relief to 192 patients with chronic pain due to osteoarthritis in the lower limbs." | 9.08 | Floctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs. Franco-Belgian Task Force. ( du Laurier, MV; Fannius, J; Lequesne, M; Reginster, JY; Verdickt, W, 1997) |
| "A parallel group study for one month of 392 patients was undertaken to define the optimal dose of nimesulide for the treatment of painful osteoarthritis (OA)." | 9.07 | Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis. ( Bourgeois, P; Dreiser, RL; Lequesne, MG; Macciocchi, A; Monti, T, 1994) |
| "To compare the relative safety and efficacy of naproxen and acetaminophen in the treatment of osteoarthritis (OA) of the knee." | 9.07 | Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee. ( Alarcón, GS; Brooks, RH; Clegg, DO; Egger, MJ; Field, EH; Neuner, R; Skosey, JL; Ward, JR; Williams, HJ; Willkens, RF, 1993) |
| "A double-blind randomized parallel group trial was undertaken to compare the acceptability and efficacy of 2 forms of analgesic treatment, DI-Antalvic (Houde Laboratories, Puteaux, France) (30 mg dextropropoxyphene and 400 mg paracetamol per capsule) and Efferalgan-Codeine (UPSA Laboratories, Rueil Malmaison, France) (30 mg codeine and 500 mg paracetamol per tablet) prescribed for 1 week at doses of 6 capsules/day and 6 tablets/day, respectively, in 141 outpatients with active osteoarthritis of the knee or hip." | 9.07 | Acceptability and efficacy of two associations of paracetamol with a central analgesic (dextropropoxyphene or codeine): comparison in osteoarthritis. ( Boissier, C; Decousus, H; Gayet, JL; Hocquart, J; Laporte-Simitsidis, S; Mismetti, P; Perpoint, B; Queneau, P; Rambaud, C, 1992) |
| "In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day." | 9.07 | Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991) |
| "This randomized, double-blind, multi-centre study was undertaken to evaluate the efficacy and safety of treatment for 4 weeks with codeine plus paracetamol versus paracetamol in relieving chronic pain due to osteoarthritis of the hip." | 9.06 | Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study. ( Andersen, HM; Branebjerg, PE; Gjøderum, O; Hvass, I; Kjærsgaard-Andersen, P; Krøner, K; Madsen, F; Nafei, A; Pedersen, L; Skov, O, 1990) |
| "Twenty-eight patients with osteoarthritis participated in a prospective, double-blind, cross-over study to compare the safety and efficacy of a new combination analgesic containing ibuprofen 200 mg, paracetamol 250 mg and codeine phosphate 10 mg per tablet (Myprodol; Rio Ethicals) with a standard treatment regimen (ibuprofen 200 mg per tablet)." | 9.06 | Comparison of a standard ibuprofen treatment regimen with a new ibuprofen/paracetamol/codeine combination in chronic osteo-arthritis. ( van Vuren, JP; Vlok, GJ, 1987) |
| "The major clinical guidelines recommend the use of acetaminophen (acetyl-para-aminophenol [APAP]) for the treatment of mild-to-moderate symptoms of osteoarthritis (OA) and only recommend the use of nonsteroidal anti-inflammatory drugs (NSAIDs) after APAP failure." | 8.86 | The role of acetaminophen in the treatment of osteoarthritis. ( Flood, J, 2010) |
| "Tramadol is increasingly used for the treatment of osteoarthritis (OA) because it does not produce gastrointestinal bleeding or renal problems and does not affect articular cartilage." | 8.84 | Tramadol for osteoarthritis: a systematic review and metaanalysis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2007) |
| "Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage." | 8.83 | Tramadol for osteoarthritis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2006) |
| "To assess the best available evidence for efficacy of paracetamol (acetaminophen) in the treatment of osteoarthritis (OA)." | 8.82 | Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials. ( Doherty, M; Jones, A; Zhang, W, 2004) |
| "Several studies have shown that colchicine exhibits an improvement in the symptoms of knee osteoarthritis (OA) but its effect on disease progression is unknown." | 7.88 | Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis? ( Agarwal, GG; Asthana, A; Das, SK; Goel, G; Srivastava, R, 2018) |
| "To determine whether acetaminophen or an acetaminophen-codeine combination is associated with an increased risk of acute cerebrovascular and cardiovascular events (ACCEs) in patients with osteoarthritis." | 7.81 | Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study. ( Cricelli, C; Cricelli, I; Fanelli, A; Lapi, F; Lora Aprile, P; Piccinni, C; Roberto, G; Simonetti, M, 2015) |
| "To identify predictors of older adults' use of exercise and/or acetaminophen, and avoidance of nonsteroidal anti-inflammatory drugs (NSAIDs) to treat their osteoarthritis pain." | 7.78 | Factors predicting older adults' use of exercise and acetaminophen for osteoarthritis pain. ( McDonald, DD; Molloy, B, 2012) |
| "In two recent osteoarthritis trials, alanine aminotransferase (ALT) elevations were observed more frequently in patients receiving acetaminophen 3." | 7.73 | Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials. ( Baggish, JS; Cooper, KM; Kuffner, EK; Parenti, DL; Temple, AR, 2006) |
| "Because there is controversy regarding the efficacy of acetaminophen in rheumatic diseases and because apparently safer nonsteroidal antiinflammatory drugs (NSAIDs) are being produced, we surveyed rheumatic disease patients about their preferences for these agents to determine the degree to which one type of therapeutic agent is preferred over the other." | 7.70 | Preference for nonsteroidal antiinflammatory drugs over acetaminophen by rheumatic disease patients: a survey of 1,799 patients with osteoarthritis, rheumatoid arthritis, and fibromyalgia. ( Lane, N; Wolfe, F; Zhao, S, 2000) |
| "To analyze results of treatment of osteoarthritis (OA) with acetaminophen and the nonsteroidal antiinflammatory drugs (NSAID) through a patient survey." | 7.70 | Preference for nonsteroidal antiinflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis. ( Callahan, LF; Cummins, P; Pincus, T; Swearingen, C, 2000) |
| "Thirty-one hospital outpatients in Thailand, 14 with rheumatoid arthritis and 17 with osteoarthritis, received 100 mg (15 patients) or 200 mg (16 patients) of controlled-release ketoprofen daily for 12 weeks." | 7.67 | Controlled-release ketoprofen in rheumatoid arthritis and osteoarthritis: comparison of two doses in Thailand. ( Chivabongs, A, 1988) |
| "Adult patients with pain from osteoarthritis receiving a stable dosage of HCD/APAP (i." | 6.77 | A randomized, 14-day, double-blind study evaluating conversion from hydrocodone/acetaminophen (Vicodin) to buprenorphine transdermal system 10 μg/h or 20 μg/h in patients with osteoarthritis pain. ( Landau, CJ; McCarberg, BH; Munera, C; Ripa, SR; Wen, W, 2012) |
| "Acetaminophen has a good risk/benefit ratio that has prompted international consensus panels to recommend its use as first-line therapy in dosages of up to 4 g/day." | 6.42 | Acetaminophen as symptomatic treatment of pain from osteoarthritis. ( Bertin, P; Jolivet-Landreau, I; Keddad, K, 2004) |
| " However, these drugs are associated with an increased risk for the development of adverse sequelae, including serious upper gastrointestinal side effects such as symptomatic ulcers, perforation, obstruction, and gastrointestinal bleeding." | 6.41 | Treatment of osteoarthritis with acetaminophen: efficacy, safety, and comparison with nonsteroidal anti-inflammatory drugs. ( Hochberg, MC; Shamoon, M, 2000) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 6.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| " The following variables were assessed: articular pain and swelling, AUSCAN and COCHIN functional questionnaires, grip and pinch strength, goniometry, perception of improvement, acetaminophen consumption, and simple radiography." | 5.51 | Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up. ( Fernandes, ADRC; Furtado, RNV; Machado, FS; Natour, J; Oliveira, HAV; Paschoal, NOS, 2022) |
| "Insured patients with a history of osteoarthritis or back pain and receiving ibuprofen, other ns-NSAIDs, COX-2i or paracetamol between 1 November, 2019 and 31 January, 2020 (study enrolment window 1) or between 1 February, 2020 and 31 October, 2020 (study enrolment window 2)." | 5.41 | Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study. ( Argyriou, G; Brash, JT; Driessen, S; Prieto-Alhambra, D; Reich, C; Seager, S; Turkmen, C; Varrassi, G; Xie, J, 2023) |
| "For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1." | 5.33 | Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2006) |
| " Given the low rates of events, at low or intermittent dosage without concurrent treatment, these 3 analgesics cannot be distinguished from each other or from background rates of serious GI toxicity." | 5.32 | Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis. ( Bruce, B; Fries, JF, 2003) |
| "The aim of this study was to evaluate the clinical effects of oral glucosamine sulfate, compared with placebo, on osteoarthritis in the temporomandibular joints (TMJs)." | 5.15 | No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study. ( Cahlin, BJ; Dahlström, L, 2011) |
| "To evaluate efficacy and safety of aceclofenac-paracetamol combination against aceclofenac alone in patients with osteoarthritis (OA) flare-up." | 5.14 | A randomized, multicentric, comparative evaluation of aceclofenac-paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up. ( Bartakke, G; Chandurkar, N; Desai, M; Kini, S; Pareek, A; Sharma, VD, 2009) |
| "To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)." | 5.14 | Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009) |
| "To assess the efficacy and safety of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA; MS-sNT), which contain morphine sulfate pellets with a sequestered naltrexone core, in treating patients with chronic, moderate-to-severe osteoarthritis (hip or knee) pain." | 5.14 | Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain. ( Hale, M; Katz, N; Morris, D; Stauffer, J, 2010) |
| "To assess the use of n-of-1 trials for short-term choice of drugs for osteoarthritis, with particular reference to comparing the efficacy of sustained-release [SR] paracetamol with celecoxib in individual patients." | 5.12 | Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials. ( Brown, RM; Del Mar, CB; McNairn, N; Nikles, CJ; Schluter, PJ; Yelland, MJ, 2007) |
| "To examine the efficacy and safety of two doses of long-acting acetaminophen in patients with osteoarthritis (OA) of the hip or knee." | 5.12 | Three-month efficacy and safety of acetaminophen extended-release for osteoarthritis pain of the hip or knee: a randomized, double-blind, placebo-controlled study. ( Altman, RD; Schweinle, JE; Temple, AR; Zinsenheim, JR, 2007) |
| "5 mg/acetaminophen 325 mg combination tablets (tramadol/APAP) as add-on therapy for subjects with osteoarthritis (OA) pain inadequately controlled by COX-2 nonsteroidal antiinflammatory drugs (NSAID)." | 5.11 | Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. ( Emkey, R; Jordan, D; Kamin, M; Rosenthal, N; Wu, SC, 2004) |
| "5 mg/acetaminophen (APAP) 325 mg combination tablets (tramadol/APAP) to existing therapy for painful osteoarthritis (OA) flare in a subset of elderly patients." | 5.11 | Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population. ( Jordan, D; Kamin, M; Rosenthal, NR; Silverfield, JC; Wu, SC, 2004) |
| "Subjects with moderate or greater wrist pain were randomized and stratified to 1 of the following treatments: efficacy evaluation (heat wrap, n=39; oral placebo, n=42) or blinding (oral acetaminophen, n=6; unheated wrap, n=6)." | 5.11 | Continuous low-level heat wrap therapy is effective for treating wrist pain. ( Erasala, GN; Hengehold, DA; Hun, L; Michlovitz, S; Weingand, KW, 2004) |
| "We provided n-of-1 trials for osteoarthritis (OA), comparing paracetamol and ibuprofen; and attention deficit hyperactivity disorder (ADHD), comparing dexamphetamine or methylphenidate and placebo." | 5.11 | Using n-of-1 trials as a clinical tool to improve prescribing. ( Clavarino, AM; Del Mar, CB; Nikles, CJ, 2005) |
| " We evaluated all dispensed prescriptions for either a cyclooxygenase (COX)-2 inhibitor, nonselective nonsteroidal anti-inflammatory drug or acetaminophen written by eligible general practitioners between May 2000 and June 2001 to elderly patients suffering from osteoarthritis." | 5.11 | Impact of a general practitioner educational intervention on osteoarthritis treatment in an elderly population. ( Beaulieu, M; Bessette, L; Choquette, D; Joseph, L; LeLorier, J; Rahme, E; Toubouti, Y, 2005) |
| "The addition of tramadol/acetaminophen tablets to existing therapy was compared with the addition of placebo in the treatment of OA flare pain." | 5.10 | Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. ( Kamin, M; Rosenthal, N; Silverfield, JC; Wu, SC, 2002) |
| "To compare the efficacy and safety of controlled release oxycodone given every 12 h around the clock with immediate release oxycodone-acetaminophen (APAP) given 4 times daily for osteoarthritis (OA) pain." | 5.09 | Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial. ( Boyd, RE; Caldwell, JR; Hague, JM; Hale, ME; Iwan, T; Lacouture, PG; Shi, M, 1999) |
| "12-week within-patient, randomised, double-blind, placebo-controlled, crossover comparison of ibuprofen with paracetamol for osteoarthritis, involving three pairs of two-week treatment periods for each participating patient." | 5.09 | Preliminary experiences with a single-patient trials service in general practice. ( Clavarino, A; Del Mar, CB; Duggan, CM; Glasziou, PP; Nikles, CJ; Yelland, MJ, 2000) |
| " Acetaminophen-based regimens are safer and may be as effective as NSAIDs for the treatment of osteoarthritis in many patients." | 5.09 | Educational program for nursing home physicians and staff to reduce use of non-steroidal anti-inflammatory drugs among nursing home residents: a randomized controlled trial. ( Brandt, KD; Griffin, MR; Pichert, JW; Ray, WA; Stein, CM; Taylor, JA, 2001) |
| "To assess the clinical efficacy of chondroitin sulfate (CS) in comparison with the nonsteroidal antiinflammatory drug (NSAID) diclofenac sodium (DS) in a medium/longterm clinical study in patients with knee osteoarthritis (OA)." | 5.08 | Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. ( Boccanera, L; Bocchi, L; Galati, M; Manopulo, R; Morreale, P; Saponati, G, 1996) |
| "A multicenter, double-blind, cross-over, random-order study compared the efficacy of floctafenin, 800 mg/day and acetaminophen, 3000 mg/day, in providing pain relief to 192 patients with chronic pain due to osteoarthritis in the lower limbs." | 5.08 | Floctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs. Franco-Belgian Task Force. ( du Laurier, MV; Fannius, J; Lequesne, M; Reginster, JY; Verdickt, W, 1997) |
| "A parallel group study for one month of 392 patients was undertaken to define the optimal dose of nimesulide for the treatment of painful osteoarthritis (OA)." | 5.07 | Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis. ( Bourgeois, P; Dreiser, RL; Lequesne, MG; Macciocchi, A; Monti, T, 1994) |
| "To compare the relative safety and efficacy of naproxen and acetaminophen in the treatment of osteoarthritis (OA) of the knee." | 5.07 | Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee. ( Alarcón, GS; Brooks, RH; Clegg, DO; Egger, MJ; Field, EH; Neuner, R; Skosey, JL; Ward, JR; Williams, HJ; Willkens, RF, 1993) |
| "Our randomized double blinded comparison of acetaminophen versus analgesic and antiinflammatory doses of ibuprofen in the treatment of 182 subjects with knee osteoarthritis (OA) systematically evaluated soft tissue tenderness and joint swelling." | 5.07 | Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1992) |
| "A double-blind randomized parallel group trial was undertaken to compare the acceptability and efficacy of 2 forms of analgesic treatment, DI-Antalvic (Houde Laboratories, Puteaux, France) (30 mg dextropropoxyphene and 400 mg paracetamol per capsule) and Efferalgan-Codeine (UPSA Laboratories, Rueil Malmaison, France) (30 mg codeine and 500 mg paracetamol per tablet) prescribed for 1 week at doses of 6 capsules/day and 6 tablets/day, respectively, in 141 outpatients with active osteoarthritis of the knee or hip." | 5.07 | Acceptability and efficacy of two associations of paracetamol with a central analgesic (dextropropoxyphene or codeine): comparison in osteoarthritis. ( Boissier, C; Decousus, H; Gayet, JL; Hocquart, J; Laporte-Simitsidis, S; Mismetti, P; Perpoint, B; Queneau, P; Rambaud, C, 1992) |
| "In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day." | 5.07 | Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991) |
| "This randomized, double-blind, multi-centre study was undertaken to evaluate the efficacy and safety of treatment for 4 weeks with codeine plus paracetamol versus paracetamol in relieving chronic pain due to osteoarthritis of the hip." | 5.06 | Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study. ( Andersen, HM; Branebjerg, PE; Gjøderum, O; Hvass, I; Kjærsgaard-Andersen, P; Krøner, K; Madsen, F; Nafei, A; Pedersen, L; Skov, O, 1990) |
| "A double-blind multicenter cross-over study was conducted on 166 outpatients with painful chronic osteoarthritis of the hip and of the femoro-tibial joints, to compare the effectiveness of glafenine and paracetamol." | 5.06 | A method for comparing analgesics: glafenine and paracetamol. Multicenter cross-over approach. ( Amor, B; Benarrosh, C, 1988) |
| "Twenty-eight patients with osteoarthritis participated in a prospective, double-blind, cross-over study to compare the safety and efficacy of a new combination analgesic containing ibuprofen 200 mg, paracetamol 250 mg and codeine phosphate 10 mg per tablet (Myprodol; Rio Ethicals) with a standard treatment regimen (ibuprofen 200 mg per tablet)." | 5.06 | Comparison of a standard ibuprofen treatment regimen with a new ibuprofen/paracetamol/codeine combination in chronic osteo-arthritis. ( van Vuren, JP; Vlok, GJ, 1987) |
| "In a double-blind cross-over trial of azapropazone and indomethacin in 20 patients with osteoarthritis of the hip and knee with four weeks on each drug, three methods of assessing pain and pain relief were used." | 5.05 | A comparison of three ways of measuring pain. ( Frank, AJ; Hort, JF; Moll, JM, 1982) |
| "Patients with osteoarthritis were entered into a single-blind trial comparing the effects on the gastric mucosa of a four week course of indomethacin, sulindac and a compound of paracetamol and dextropropoxyphene (Distalgesic)." | 5.05 | Histological study of the effects of three anti-inflammatory preparations on the gastric mucosa. ( Irani, MS; McIntyre, RL; Piris, J, 1981) |
| "In a between-patient single blind controlled trial, two groups of patients with osteoarthritis were treated for two weeks with either Fortagesic or naproxen tablets." | 5.04 | Successful use of a moderate analgesic (Fortagesic) in the symptomatic treatment of osteoarthritis. ( Rooney, GI, 1979) |
| "Animal experiments and uncontrolled clinical experience indicate that imipramine should relieve pain or enhance the effect of analgesics in osteoarthritis." | 5.04 | A clinical Trial of Tofranil in osteo-arthritis. ( Glick, EN, 1976) |
| "This meta-analysis assessed the efficacy of duloxetine versus other oral treatments used after failure of acetaminophen for management of patients with osteoarthritis." | 4.90 | The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: a systematic literature review and meta-analysis. ( Gahn, J; Han, B; Happich, M; Myers, J; Paget, MA; Price, K; Wielage, RC, 2014) |
| "The major clinical guidelines recommend the use of acetaminophen (acetyl-para-aminophenol [APAP]) for the treatment of mild-to-moderate symptoms of osteoarthritis (OA) and only recommend the use of nonsteroidal anti-inflammatory drugs (NSAIDs) after APAP failure." | 4.86 | The role of acetaminophen in the treatment of osteoarthritis. ( Flood, J, 2010) |
| "Tramadol is increasingly used for the treatment of osteoarthritis (OA) because it does not produce gastrointestinal bleeding or renal problems and does not affect articular cartilage." | 4.84 | Tramadol for osteoarthritis: a systematic review and metaanalysis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2007) |
| "To assess the efficacy of cyclooxygenase-2 selective inhibitors (coxibs) in osteoarthritis (OA) and their gastrointestinal, cardiovascular, renovascular, and hepatic side effects compared with traditional nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen." | 4.84 | COX-2 selective inhibitors in the treatment of osteoarthritis. ( Hochberg, M; Laine, L; Rostom, A; White, WB, 2008) |
| "Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage." | 4.83 | Tramadol for osteoarthritis. ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2006) |
| "To assess the best available evidence for efficacy of paracetamol (acetaminophen) in the treatment of osteoarthritis (OA)." | 4.82 | Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials. ( Doherty, M; Jones, A; Zhang, W, 2004) |
| "Osteoarthritis is treated with a variety of pharmacologic therapies, including acetaminophen, traditional nonsteroidal anti-inflammatory drugs, cyclo-oxygenase-2 inhibitors, intra-articular steroids, viscosupplements, glucosamine, chondroitin sulfate, capsaicin, and vitamins." | 4.81 | Pharmacologic therapy for osteoarthritis. ( Goldberg, SH; Lonner, JH; Von Feldt, JM, 2002) |
| "Recent controversies on the safety profiles of opioids and paracetamol (acetaminophen) have led to changes in clinical guidance on osteoarthritis (OA) management." | 3.88 | Analgesic Use and Risk for Acute Coronary Events in Patients With Osteoarthritis: A Population-based, Nested Case-control Study. ( Aragón, M; Elorza, JM; Marsal, JR; Morros, R; Pontes, C; Prieto-Alhambra, D, 2018) |
| "Several studies have shown that colchicine exhibits an improvement in the symptoms of knee osteoarthritis (OA) but its effect on disease progression is unknown." | 3.88 | Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis? ( Agarwal, GG; Asthana, A; Das, SK; Goel, G; Srivastava, R, 2018) |
| "There are contrasting positions concerning the benefit-risk ratio of acetaminophen use for osteoarthritis (OA)-related pain." | 3.85 | Regular use of acetaminophen or acetaminophen-codeine combinations and prescription of rescue therapy with non-steroidal anti-inflammatory drugs: a population-based study in primary care. ( Cricelli, C; Cricelli, I; Fanelli, A; Fornasari, D; Lapi, F; Lombardi, N; Lora Aprile, P; Simonetti, M; Vannacci, A, 2017) |
| "To determine whether acetaminophen or an acetaminophen-codeine combination is associated with an increased risk of acute cerebrovascular and cardiovascular events (ACCEs) in patients with osteoarthritis." | 3.81 | Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study. ( Cricelli, C; Cricelli, I; Fanelli, A; Lapi, F; Lora Aprile, P; Piccinni, C; Roberto, G; Simonetti, M, 2015) |
| " Paracetamol (acetaminophen) is generally recommended as a first-choice analgesic in osteoarthritis pain." | 3.79 | Managing osteoarthritis pain in the older population. ( Cunningham, E; Passmore, P, 2013) |
| "To identify predictors of older adults' use of exercise and/or acetaminophen, and avoidance of nonsteroidal anti-inflammatory drugs (NSAIDs) to treat their osteoarthritis pain." | 3.78 | Factors predicting older adults' use of exercise and acetaminophen for osteoarthritis pain. ( McDonald, DD; Molloy, B, 2012) |
| "To explore the key motivators behind selection of analgesics (nonsteroidal antiinflammatory drugs [NSAIDs], acetaminophen, and complementary medications [CMs]) by patients with osteoarthritis (OA)." | 3.77 | "It looks after me": how older patients make decisions about analgesics for osteoarthritis. ( Day, RO; Lipworth, WL; Milder, TY; Ritchie, JE; Williams, KM, 2011) |
| "This paper reports on a study conducted to describe what traditional and non-traditional treatments older adults with osteoarthritis use for pain management, their reported pain relief, and factors associated with use of recommended initial gold standard treatment (acetaminophen/paracetamol or non-steroidal anti-inflammatory drugs, and exercise and/or physical therapy) as designated by conventional western medicine." | 3.75 | Use of recommended osteoarthritis pain treatment by older adults. ( McDonald, DD; Merkle, D, 2009) |
| " For analgesia and osteoarthritis, acetaminophen (Tylenol, and others) or tramadol (Ultram, and others) are reasonable alternatives to NSAIDS." | 3.73 | NSAID alternatives. ( , 2005) |
| "In two recent osteoarthritis trials, alanine aminotransferase (ALT) elevations were observed more frequently in patients receiving acetaminophen 3." | 3.73 | Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials. ( Baggish, JS; Cooper, KM; Kuffner, EK; Parenti, DL; Temple, AR, 2006) |
| "To describe an in vivo model in the rat in which change in weight distribution is used as a measure of disease progression and efficacy of acetaminophen and two nonsteroidal anti-inflammatory drugs (NSAIDs) in a model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA)." | 3.72 | Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. ( Bove, SE; Brooker, RM; Calcaterra, SL; Guzman, RE; Huber, CM; Juneau, PL; Kilgore, KS; Schrier, DJ, 2003) |
| "To investigate recent national trends in nonsteroidal antiinflammatory drug (NSAID) and acetaminophen use for osteoarthritis (OA)." | 3.71 | Trends in medication use for osteoarthritis treatment. ( Ausiello, JC; Stafford, RS, 2002) |
| "Because there is controversy regarding the efficacy of acetaminophen in rheumatic diseases and because apparently safer nonsteroidal antiinflammatory drugs (NSAIDs) are being produced, we surveyed rheumatic disease patients about their preferences for these agents to determine the degree to which one type of therapeutic agent is preferred over the other." | 3.70 | Preference for nonsteroidal antiinflammatory drugs over acetaminophen by rheumatic disease patients: a survey of 1,799 patients with osteoarthritis, rheumatoid arthritis, and fibromyalgia. ( Lane, N; Wolfe, F; Zhao, S, 2000) |
| "To analyze results of treatment of osteoarthritis (OA) with acetaminophen and the nonsteroidal antiinflammatory drugs (NSAID) through a patient survey." | 3.70 | Preference for nonsteroidal antiinflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis. ( Callahan, LF; Cummins, P; Pincus, T; Swearingen, C, 2000) |
| "In patients with a confirmed diagnosis of osteoarthritis, acetaminophen is now recommended as first-line medical therapy." | 3.69 | Osteoarthritis: new roles for drug therapy and surgery. Interview by Peter Pompei. ( Clyman, BB, 1996) |
| "The traditional "aspirin first" approach to the treatment of osteoarthritis and rheumatoid arthritis is undergoing serious reappraisal." | 3.67 | Pain and inflammation. ( Calin, A, 1984) |
| "The analgesic effects of dextropropoxyphene and paracetamol and that of a combination of the two drugs were assessed in 24 patients who suffered from either rheumatoid arthritis or osteoarthritis." | 3.67 | Further look at dextropropoxyphene with or without paracetamol in the treatment of arthritis. ( Cunningham, TJ; Mathews, JD; Mitchell, H; Muirden, KD, 1984) |
| "Thirty-one hospital outpatients in Thailand, 14 with rheumatoid arthritis and 17 with osteoarthritis, received 100 mg (15 patients) or 200 mg (16 patients) of controlled-release ketoprofen daily for 12 weeks." | 3.67 | Controlled-release ketoprofen in rheumatoid arthritis and osteoarthritis: comparison of two doses in Thailand. ( Chivabongs, A, 1988) |
| "A survey of 763 patients with rheumatoid arthritis and 145 with osteoarthritis in six clinics in New Zealand showed no association between aspirin intake and a score designed to detect analgesic nephropathy." | 3.65 | Aspirin and the kidney. New Zealand Rheumatism Association Study. ( , 1974) |
| " However, long-term use of these agents will lead to inevitable side effects, even aggravate cartilage loss." | 3.01 | Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis. ( Chu, Y; Fan, Z; Guo, X; Liang, Z; Ren, W; Wang, W; Zhang, P; Zhou, G, 2023) |
| "Adult patients with pain from osteoarthritis receiving a stable dosage of HCD/APAP (i." | 2.77 | A randomized, 14-day, double-blind study evaluating conversion from hydrocodone/acetaminophen (Vicodin) to buprenorphine transdermal system 10 μg/h or 20 μg/h in patients with osteoarthritis pain. ( Landau, CJ; McCarberg, BH; Munera, C; Ripa, SR; Wen, W, 2012) |
| "The medicinal treatment of osteoarthritis (OA) is mostly symptomatic to relieve pain and incapacity with analgesics and non-steroidal anti-inflammatory drugs (NSAIDs), drugs with well-known risks." | 2.74 | Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. ( Forest, K; Girodet, PO; Jacquet, A; Mallet, L; Moore, N; Pariente, A, 2009) |
| "We extracted pain and adverse events outcomes from 36 systematic reviews that assessed the efficacy of paracetamol in 44 painful conditions." | 2.72 | The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews. ( Abdel Shaheed, C; Ahedi, H; Day, RO; Dmitritchenko, A; Ferreira, GE; Kamper, S; Langendyk, V; Latimer, J; Lin, C; Maher, CG; McLachlan, AJ; McLachlan, H; Saragiotto, B; Stanaway, F, 2021) |
| " Patients were allocated at random to receive 2 tablets 3-times daily of either treatment for 6 weeks and were then crossed over to the alternative treatment at the same dosage for a further 6 weeks." | 2.65 | Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis. ( Boston, PF; Matts, SG, 1983) |
| "Two studies on 41 patients with osteoarthrosis of the hip or knee have shown fenoprofen-a compound with analgesic and anti-inflammatory properties-to be an effective addition to the drug treatment of these conditions." | 2.64 | Fenoprofen in treatment of osteoarthrosis of hip and knee. ( Hart, FD; Huskisson, EC; Wojtulewski, JA, 1974) |
| " Furthermore, there have been recent concerns over the safety profile of paracetamol, with reports of gastrointestinal, cardiovascular, hepatic and renal adverse events." | 2.61 | Safety of Paracetamol in Osteoarthritis: What Does the Literature Say? ( Arden, N; Avouac, B; Conaghan, PG; Migliore, A; Rizzoli, R, 2019) |
| "Acetaminophen has been commonly used as the fi rst-line treatment for OA pain and cLBP, but its long-term use is not recommended based on recent evidence." | 2.61 | Evidence-Based Recommendations on the Pharmacological Management of Osteoarthritis and Chronic Low Back Pain: An Asian Consensus ( Ip, AKK; Murakami, T; Shin, HK; Sun, WZ; Tam, CK; Ushida, T; Wang, JH; Williamson, OD; Yabuki, S, 2019) |
| "Osteoarthritis is a common progressive disease in older adults, and those affected often have impaired physical function, co-existing disease states, and reduced quality of life." | 2.55 | Move it or Lose it. Is it Reasonable for Older Adults with Osteoarthritis to Continue to Use Paracetamol in Order to Maintain Physical Activity? ( Cooke, J; Cooper, G; Lee, K; Shield, A, 2017) |
| " A good knowledge of the different strategies to decrease the gastrointestinal and cardiovascular toxic effects of NSAIDs is key to the management of OA." | 2.52 | Safety and efficacy of paracetamol and NSAIDs in osteoarthritis: which drug to recommend? ( Frazier, A; Latourte, A; Richette, P, 2015) |
| " However, there is concern for the possible side effects resulting from long term use of those medications." | 2.52 | Controversy: hirudotherapy (leech therapy) as an alternative treatment for osteoarthritis. ( Bunawan, NC; Gunawan, F; Turner, JH; Wibowo, YR, 2015) |
| " NSAIDs long-term use associated with serious adverse effects." | 2.48 | [Antiinflammatory therapy in ostheoarthritis including omega 3 and omega 6 fatty acids]. ( Dzielska-Olczak, M; Nowak, JZ, 2012) |
| "Osteoarthritis (OA) is the most common cause of disability in older adults, and although analgesic use can be helpful, it can also result in adverse drug events." | 2.48 | Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioid analgesics. ( Hanlon, JT; Marcum, ZA; O'Neil, CK, 2012) |
| "Treatment with tramadol or opioids is usually reserved for severe pain associated with OA." | 2.47 | Treatment options for osteoarthritis: considerations for older adults. ( Dunican, KC; Lynch, AM; Seed, SM, 2011) |
| "In this systematic review we present information relating to the benefits and harms of the following interventions: differences in efficacy among different oral NSAIDs, between oral and topical NSAIDs, and between oral NSAIDs and alternative analgesics; dose-response relationship of oral NSAIDs; and H(2) blockers, misoprostol, or proton pump inhibitors to mitigate gastrointestinal adverse effects of oral NSAIDs." | 2.46 | NSAIDs. ( Gøtzsche, PC, 2010) |
| " NSAIDs are typically more effective than acetaminophen; however, because of adverse effects associated with long-term use of NSAIDS, acetaminophen is considered first-line therapy." | 2.45 | Osteoarthritis: a review of treatment options. ( Dunican, KC; Lynch, AM; Seed, SM, 2009) |
| "In this systematic review we present information relating to the benefits and harms of the following interventions: alternative analgesics, H(2) blockers, misoprostol, NSAIDs (systemic, topical, differences in efficacy between, dose-response relationship of), proton pump inhibitors." | 2.44 | NSAIDs. ( Gøtzsche, PC, 2007) |
| "Primary osteoarthritis is mostly related to aging, whereas, secondary osteoarthritis is caused by another disease or condition." | 2.43 | Osteoarthritis. ( Mahajan, A; Tandon, V; Verma, S, 2005) |
| " Appropriately dosed and monitored use of opioids for OA pain, when more conservative methods have failed, has potentially fewer life-threatening complications associated with it than the more commonly and often less successfully employed pharmacotherapeutic approaches to care." | 2.43 | The use of opioids in the treatment of osteoarthritis: when, why, and how? ( Bajwa, ZH; Goodwin, JL; Kraemer, JJ, 2005) |
| " Because NSAIDs are associated with adverse renal effects, they should be used cautiously in patients with advanced renal disease." | 2.43 | Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease. ( Johnson, J; Weinryb, J, 2006) |
| "Acetaminophen has a good risk/benefit ratio that has prompted international consensus panels to recommend its use as first-line therapy in dosages of up to 4 g/day." | 2.42 | Acetaminophen as symptomatic treatment of pain from osteoarthritis. ( Bertin, P; Jolivet-Landreau, I; Keddad, K, 2004) |
| " However, these drugs are associated with an increased risk for the development of adverse sequelae, including serious upper gastrointestinal side effects such as symptomatic ulcers, perforation, obstruction, and gastrointestinal bleeding." | 2.41 | Treatment of osteoarthritis with acetaminophen: efficacy, safety, and comparison with nonsteroidal anti-inflammatory drugs. ( Hochberg, MC; Shamoon, M, 2000) |
| "Pain is the most prominent symptom and clinical finding in osteoarthritis (OA)." | 2.41 | Treatment of chronic pain in osteoarthritis: do opioids have a clinical role? ( Lipman, AG, 2001) |
| " During repeated dosage with the specific COX-2 inhibitors, the 24 hour urinary excretion of sodium is only inhibited for the first day of treatment while the excretion of sodium is still decreased over the first 3 hours after the individual doses." | 2.41 | Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol). ( Day, RO; Graham, GG; Graham, RI, 2002) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 2.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| "Chronic pain affects 75 million US citizens." | 2.40 | Non-NSAID pharmacologic treatment options for the management of chronic pain. ( Schnitzer, TJ, 1998) |
| "Symptomatic treatments for osteoarthritis (OA) provide only small-to-moderate efficacy over placebo in randomised controlled trials (RCTs)." | 1.62 | Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis. ( Doherty, M; Lei, G; Persson, MSM; van Middelkoop, M; Wei, J; Xiong, Y; Zeng, C; Zhang, W, 2021) |
| "Osteoarthritis is a common debilitating condition affecting a substantial portion of the population and is an accepted consequence of ageing and overuse." | 1.56 | Why are we still using opioids for osteoarthritis? ( Oettinger, J; Yip, K, 2020) |
| " Less frequent dosing of the ERP formulation may explain the difference in usage patterns." | 1.43 | Prescription usage patterns of two formulations of paracetamol in osteoarthritis: Australia-wide experience 2008-11. ( Calcino, G; Dunagan, F; Ortiz, M, 2016) |
| "Tramadol is an option in the case patients will not respond satisfactorily to NSAIDs." | 1.39 | Pharmacologic treatment of hand-, knee- and hip-osteoarthritis. ( Bobacz, K, 2013) |
| "Recommended pain treatments for osteoarthritis (OA) and chronic low back pain (CLBP) are suboptimal, and limited information is available regarding patterns of pharmacotherapy among patients with these conditions." | 1.38 | Therapy switching, augmentation, and discontinuation in patients with osteoarthritis and chronic low back pain. ( Emery, P; Gore, M; Leslie, DL; Sadosky, AB; Tai, KS, 2012) |
| "When rofecoxib was withdrawn in 2004, paracetamol should have been offered as replacement." | 1.35 | Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market. ( Barozzi, N; Tett, SE, 2009) |
| "For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1." | 1.33 | Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2006) |
| " It is recommended to use the same dosages and dosage forms that the patient used before the trial, to start the trial with a run-in period, to formulate both general and individualized decision rules regarding the efficacy of treatment, to adjust treatment policies immediately after the trial, and to provide adequate instructions and support if treatment is adjusted." | 1.33 | Conducting research in individual patients: lessons learnt from two series of N-of-1 trials. ( de Vries, TP; Stalman, WA; van der Windt, DA; Wegman, AC, 2006) |
| " Given the low rates of events, at low or intermittent dosage without concurrent treatment, these 3 analgesics cannot be distinguished from each other or from background rates of serious GI toxicity." | 1.32 | Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis. ( Bruce, B; Fries, JF, 2003) |
| "(1) The treatment of osteoarthritis is symptomatic, and relies first and foremost on physical therapy." | 1.31 | Treatment of osteoarthritic pain: systemic drug therapy is not always necessary. ( , 2000) |
| "Osteoarthritis is a chronic disease that has exacerbations and remissions." | 1.29 | Osteoarthritis treatment update. Minimizing pain while limiting patient risk. ( Schnitzer, TJ, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (13.60) | 18.7374 |
| 1990's | 31 (13.60) | 18.2507 |
| 2000's | 90 (39.47) | 29.6817 |
| 2010's | 61 (26.75) | 24.3611 |
| 2020's | 15 (6.58) | 2.80 |
| Authors | Studies |
|---|---|
| Paschoal, NOS | 1 |
| Natour, J | 1 |
| Machado, FS | 1 |
| Oliveira, HAV | 1 |
| Fernandes, ADRC | 1 |
| Furtado, RNV | 1 |
| Wang, Y | 1 |
| Fan, M | 1 |
| Wang, H | 1 |
| You, Y | 1 |
| Wei, C | 1 |
| Liu, M | 1 |
| Luo, A | 1 |
| Xu, X | 1 |
| Duan, X | 1 |
| Pickering, G | 1 |
| Mezouar, L | 1 |
| Kechemir, H | 1 |
| Ebel-Bitoun, C | 1 |
| Xie, J | 1 |
| Brash, JT | 1 |
| Turkmen, C | 1 |
| Driessen, S | 1 |
| Varrassi, G | 1 |
| Argyriou, G | 1 |
| Seager, S | 1 |
| Reich, C | 1 |
| Prieto-Alhambra, D | 2 |
| Wang, W | 1 |
| Chu, Y | 1 |
| Zhang, P | 1 |
| Liang, Z | 1 |
| Fan, Z | 1 |
| Guo, X | 1 |
| Zhou, G | 1 |
| Ren, W | 1 |
| Yip, K | 1 |
| Oettinger, J | 1 |
| Apostu, D | 1 |
| Lucaciu, O | 1 |
| Mester, A | 1 |
| Oltean-Dan, D | 1 |
| Baciut, M | 1 |
| Baciut, G | 1 |
| Bran, S | 1 |
| Onisor, F | 1 |
| Piciu, A | 1 |
| Pasca, RD | 1 |
| Maxim, A | 1 |
| Benea, H | 1 |
| Vicentini, M | 1 |
| Mancuso, P | 1 |
| Giorgi Rossi, P | 1 |
| Di Pede, S | 1 |
| Pellati, M | 1 |
| Gandolfi, A | 1 |
| Zoboli, D | 1 |
| Riccò, D | 1 |
| Busani, C | 1 |
| Ferretti, A | 1 |
| Banks, C | 1 |
| Hughes, K | 1 |
| Simpkins, C | 1 |
| Elliott, DP | 1 |
| Kloppenburg, M | 1 |
| Berenbaum, F | 1 |
| Trivedi, S | 1 |
| Fang, W | 1 |
| Ayyalasomayajula, I | 1 |
| Vangsness, CT | 1 |
| Zeng, C | 2 |
| Zhang, W | 4 |
| Doherty, M | 5 |
| Persson, MSM | 2 |
| Mallen, C | 3 |
| Swain, S | 1 |
| Li, X | 1 |
| Wei, J | 2 |
| Lei, G | 2 |
| Zhang, Y | 1 |
| Chandan, JS | 1 |
| Zemedikun, DT | 1 |
| Thayakaran, R | 1 |
| Byne, N | 1 |
| Dhalla, S | 1 |
| Acosta-Mena, D | 1 |
| Gokhale, KM | 1 |
| Thomas, T | 1 |
| Sainsbury, C | 1 |
| Subramanian, A | 1 |
| Cooper, J | 1 |
| Anand, A | 1 |
| Okoth, KO | 1 |
| Wang, J | 1 |
| Adderley, NJ | 1 |
| Taverner, T | 1 |
| Denniston, AK | 1 |
| Lord, J | 1 |
| Thomas, GN | 1 |
| Buckley, CD | 1 |
| Raza, K | 1 |
| Bhala, N | 1 |
| Nirantharakumar, K | 1 |
| Haroon, S | 1 |
| Paglia, DN | 1 |
| Kanjilal, D | 1 |
| Kadkoy, Y | 1 |
| Moskonas, S | 1 |
| Wetterstrand, C | 1 |
| Lin, A | 1 |
| Galloway, J | 1 |
| Tompson, J | 1 |
| Culbertson, MD | 1 |
| O'Connor, JP | 1 |
| Abdel Shaheed, C | 1 |
| Ferreira, GE | 1 |
| Dmitritchenko, A | 1 |
| McLachlan, AJ | 1 |
| Day, RO | 4 |
| Saragiotto, B | 1 |
| Lin, C | 1 |
| Langendyk, V | 1 |
| Stanaway, F | 1 |
| Latimer, J | 1 |
| Kamper, S | 1 |
| McLachlan, H | 1 |
| Ahedi, H | 1 |
| Maher, CG | 1 |
| D'Arcy, Y | 1 |
| Mantyh, P | 1 |
| Yaksh, T | 1 |
| Donevan, S | 1 |
| Hall, J | 1 |
| Sadrarhami, M | 1 |
| Viktrup, L | 1 |
| Xiong, Y | 1 |
| van Middelkoop, M | 1 |
| Vannacci, A | 1 |
| Lombardi, N | 1 |
| Simonetti, M | 2 |
| Fornasari, D | 1 |
| Fanelli, A | 2 |
| Cricelli, I | 2 |
| Cricelli, C | 2 |
| Lora Aprile, P | 2 |
| Lapi, F | 2 |
| Inacio, MCS | 1 |
| Cashman, K | 1 |
| Pratt, NL | 1 |
| Gillam, MH | 1 |
| Caughey, G | 1 |
| Graves, SE | 1 |
| Roughead, EE | 1 |
| Rasmussen, S | 1 |
| Pontes, C | 1 |
| Marsal, JR | 1 |
| Elorza, JM | 1 |
| Aragón, M | 1 |
| Morros, R | 1 |
| Benitez-Camps, M | 1 |
| Morros Padrós, R | 1 |
| Pera-Pujadas, H | 1 |
| Dalfó Baqué, A | 1 |
| Bayó Llibre, J | 1 |
| Rebagliato Nadal, O | 1 |
| Cortès Martinez, J | 1 |
| García Sangenís, A | 1 |
| Roca Saumell, C | 1 |
| Coll de Tuero, G | 1 |
| Vinyoles-Bargalló, E | 1 |
| Majeed, MH | 1 |
| Sherazi, SAA | 1 |
| Bacon, D | 1 |
| Bajwa, ZH | 2 |
| Trentalange, M | 1 |
| Runels, T | 1 |
| Bean, A | 1 |
| Kerns, RD | 1 |
| Bair, MJ | 1 |
| Brody, AA | 1 |
| Brandt, CA | 1 |
| Hwang, U | 1 |
| Wiet, SG | 1 |
| Boyle, KE | 1 |
| Bass, MB | 1 |
| Conaghan, PG | 4 |
| Arden, N | 1 |
| Avouac, B | 1 |
| Migliore, A | 1 |
| Rizzoli, R | 1 |
| Yabuki, S | 1 |
| Ip, AKK | 1 |
| Tam, CK | 1 |
| Murakami, T | 1 |
| Ushida, T | 1 |
| Wang, JH | 1 |
| Shin, HK | 1 |
| Sun, WZ | 1 |
| Williamson, OD | 1 |
| Fogleman, CD | 1 |
| Laba, TL | 1 |
| Brien, JA | 1 |
| Fransen, M | 1 |
| Jan, S | 1 |
| Bobacz, K | 1 |
| Passmore, P | 1 |
| Cunningham, E | 1 |
| Bertin, P | 2 |
| Becquemont, L | 1 |
| Corruble, E | 1 |
| Derumeaux, G | 1 |
| Falissard, B | 1 |
| Hanon, O | 1 |
| Pinget, M | 1 |
| Forette, F | 1 |
| Richette, P | 2 |
| Wise, J | 1 |
| Myers, J | 1 |
| Wielage, RC | 1 |
| Han, B | 1 |
| Price, K | 1 |
| Gahn, J | 1 |
| Paget, MA | 1 |
| Happich, M | 1 |
| Berry, L | 1 |
| Ma, J | 1 |
| Talukdar, R | 1 |
| Gainers-Hasugluw, V | 1 |
| Hay, E | 2 |
| Traynor, K | 1 |
| Latourte, A | 1 |
| Frazier, A | 1 |
| Roberts, E | 1 |
| Gunawan, F | 1 |
| Wibowo, YR | 1 |
| Bunawan, NC | 1 |
| Turner, JH | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Cluster Randomised Trial to Measure the Impact of a Free Distribution of Paracetamol to Osteoarthritic Patients on Non-steroidal Anti-inflammatory Drugs (NSAID) and Proton Pump Inhibitors (PPI) Prescription[NCT02691754] | 16 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| A Randomized Controlled Study Evaluating Suprainguinal Fascia Iliaca Compartment Block in Direct Anterior Approach to Total Hip Arthroplasty - A Pilot Study[NCT05237479] | 0 participants (Actual) | Interventional | 2022-06-30 | Withdrawn (stopped due to Study never approved by IRB or initiated) | |||
| Ultrasound Guided Sacroiliac Joint Injections With Ketorolac Versus Corticosteroid: A Prospective Non-inferiority Study[NCT06081101] | Early Phase 1 | 80 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| The Effect of Glucosamine Sulphate on Structural Disease Progression in Knee Osteoarthritis and the Cost-effectiveness of Glucosamine Sulphate for Knee Arthritis.[NCT00513422] | Phase 4 | 600 participants (Anticipated) | Interventional | 2007-10-31 | Active, not recruiting | ||
| National Observatory on the Therapeutic Management in Ambulatory Care Patients Aged 65 and Over, With Diabetes Type 2, Chronic Pain or Atrial Fibrillation[NCT01065909] | 3,491 participants (Actual) | Observational | 2009-05-31 | Completed | |||
| Relevance of the Interaction Between Antihypertensive and Antirheumatic Drugs in a Family Practice[NCT00631514] | Phase 4 | 88 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Efficiency And Quality In Post-Surgical Pain Therapy After Discharge[NCT05221866] | 711 participants (Actual) | Interventional | 2022-03-14 | Completed | |||
| UControlPain App (This is the Official IRB Title)[NCT03833648] | 60 participants (Actual) | Interventional | 2019-06-19 | Completed | |||
| Randomized Double-Blind Study of Food Supplement Phytalgic on Symptoms of Osteoarthritis[NCT00666523] | 81 participants (Actual) | Interventional | 2007-01-31 | Completed | |||
| A Randomized, Double-Blind Study Evaluating the Dose Conversion From Vicodin® to Buprenorphine Transdermal System (BTDS) in Subjects With Osteoarthritis (OA) Pain[NCT00312572] | Phase 3 | 204 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| Role of Vitamin D (Alphacalcidol) Supplement to Reduce Pain and Cartilage Oligomeric Matrix Protein Serum Levels in Geriatric Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Study[NCT04405960] | Phase 3 | 146 participants (Actual) | Interventional | 2017-07-01 | Completed | ||
| A Randomized, Double-Blind, Placebo-Controlled Study Evaluating Acetaminophen Extended Release (3900 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee.[NCT00240799] | Phase 3 | 542 participants (Actual) | Interventional | Completed | |||
| A Randomized, Double-Blind, Placebo-Controlled Study Evaluating Acetaminophen Extended Release (1950 mg/Day or 3900 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee[NCT00240786] | Phase 3 | 483 participants (Actual) | Interventional | 2002-04-30 | Completed | ||
| Effectiveness of Percutaneous Microelectrolysis in the Decrease of Pain in Myofascial Trigger Points: Evaluation Through Algometry and Visual Analog Scale. Randomized Controlled Trial.[NCT03636386] | 48 participants (Actual) | Interventional | 2018-05-23 | Completed | |||
| MiniTightRope Suspensionplasty Compared With Ligamentous Reconstruction Tendon Interposition for the Treatment of Basilar Thumb Arthritis. A Randomized Clinical Trial[NCT02591368] | 7 participants (Actual) | Interventional | 2015-10-31 | Terminated | |||
| Arthroscopic Surgery Versus Non-surgical Treatment of Osteoarthritis of the Knee[NCT00158431] | Phase 3 | 186 participants (Actual) | Interventional | 1999-01-31 | Completed | ||
| Clinical Evaluation of Condrosulf 800 mg in the Treatment of Symptomatic OA of the Hand: a 6-month, Double-blind, Placebo Controlled Study[NCT00291499] | Phase 3 | 163 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| Study of the Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee[NCT00604539] | Phase 3 | 70 participants (Anticipated) | Interventional | 2008-02-29 | Completed | ||
| A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755] | 62 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| Effectiveness of Distal Peripheral Nerve Blocks on Postoperative Pain Management After Ambulatory Thumb Resection Arthroplasty.[NCT01597479] | Phase 4 | 52 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| The Effects of Bariatric Surgery Weight Loss on Knee Pain in Patients With Osteoarthritis of the Knee[NCT00752765] | 30 participants (Anticipated) | Observational | 2008-09-30 | Completed | |||
| Assessment and Treatment Responses to Patient Education and Basic Body Awareness Therapy in Hip Osteoarthritis: a Randomized Controlled Trial[NCT02884531] | 101 participants (Actual) | Interventional | 2015-10-31 | Completed | |||
| Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722772] | 60 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
| Efficacy of Subcutaneous Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722811] | 60 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
| Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The indicator variable was 1 = completion, and 0 = noncompletion. For the primary efficacy analysis, the percentage of subjects who completed the double-blind phase was computed with its 95% confidence interval (CI) for each treatment regimen (starting dose of BTDS 10 or BTDS 20) across and within baseline Vicodin® stratum (15 to 22.5mg/day vs >22.5 to 30 mg/day as determined by the daily average hydrocodone dose during the run-in period). (NCT00312572)
Timeframe: 14 days
| Intervention | Percentage of Participants (Number) | ||
|---|---|---|---|
| 15 - 22.5 mg HCD (Stratum 1) | more than 22.5 - 30 mg HCD (Stratum 2) | Overall | |
| Combined Total | 85 | 82 | 84 |
| Double-blind BTDS 10/20 | 88 | 85 | 87 |
| Double-blind BTDS 20 | 83 | 79 | 82 |
Magnitude of pain expressed in millimeters (mm) referred by participants. PI was evaluated through visual analogue scale at moment of performing pressure algometry test in the sensitive point of upper trapezius muscle. PI was assessed with an analogous visual scale where the participant will mark the pain generated by the algometry on a scale of 1 to 100 millimeters. PI was valued in four occasions: PI1 pre (baseline), PI1 post, PI 2 (at day 3) and PI 3 (at day 7). (NCT03636386)
Timeframe: PIpre1 (baseline), PIpost1 (post baseline), PI2 (Day 3), PI3 (Day 7), assessed an average of 3 minutes at each session
| Intervention | mm (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| PIpre1 | PIpost1 | PI2 | PI3 | PIdiff1-1 | PIdiff2-1 | PIdiff3-1 | |
| Control Group (Ultrasound Therapy) | 31.4 | 24.8 | 23.8 | 20.0 | -6.6 | -7.6 | -11.5 |
| Percutaneous Microelectrolysis Group (MEP) | 32.1 | 24.6 | 21.6 | 18.1 | -7.5 | -10.5 | -14.0 |
Pain Intensity expressed in kilograms per square centimeter(kg/cm2) reported by participants when performing algometry test at sensitive point of upper trapezius muscle. PPT was valued in four occasions: PPT1 pre (baseline), PPT1 post, PPT 2 (at day 3) and PPT 3 (at day 7). PPT will be evaluated through the BASELINE® pressure algometer. (NCT03636386)
Timeframe: PPTpre1 (baseline), PPTpost1 (post baseline), PPT2 (Day 3), PPT3 (Day 7), assessed an average of 30 minutes at each session
| Intervention | Kg/cm2 (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| PPTpre1 | PPTpost1 | PPT2 | PPT3 | PPTdiff1-1 | PPTdiff2-1 | PPTdiff3-1 | |
| Control Group (Ultrasound Therapy) | 1.4 | 1.6 | 1.6 | 1.7 | 0.2 | 0.2 | 0.3 |
| Percutaneous Microelectrolysis Group (MEP) | 1.4 | 1.6 | 1.7 | 1.9 | 0.2 | 0.4 | 0.5 |
"Functional Index for Hand Osteoarthritis (Dreiser's Index). Range 0-30 Patients reported the severity of their symptoms by answering a set of 10 questions. Severity was rated on a numerical scale (0 = possible without difficulty, 1 = possible with slight difficulty, 2 =possible with great difficulty, and 3 = impossible), being 30 points the worst possible pain score.~Change calculated as difference between the month 6 value and baseline value~Target hand defined as the patient's most symptomatic hand or, when both hands were equally painful, the patient's dominant hand" (NCT00291499)
Timeframe: 6 month
| Intervention | score on a scale (Mean) |
|---|---|
| Chondroitin 4&6 Sulfate (Condrosulf) | -2.9 |
| Placebo | -0.7 |
Intensity of global spontaneous pain is evaluated by the patient himself on a Huskisson's visual analogue scale (VAS) of 100 mm. 0=no pain 100=max pain Change calculated as difference between Month 6 value and baseline value target hand is defined as the patient's most symptomatic hand or, when both hands were equally painful, the patient's dominant hand. (NCT00291499)
Timeframe: 6 months
| Intervention | mm (Mean) |
|---|---|
| Chondroitin 4&6 Sulfate (Condrosulf) | -20 |
| Placebo | -11.3 |
"Grip strength determined on both hands using a Jamar dynamometer.Patients were required to grip the dynamometer handle and squeeze as hard as possible according to their individual pain limits. The right hand grip was measured first, then the left; this procedure was performed 3 times. The mean value of these 3 measurements was recorded.~Change calculated as difference between the month 6 value and baseline value" (NCT00291499)
Timeframe: 6 months
| Intervention | Kg/cm^2 (Mean) |
|---|---|
| Chondroitin 4&6 Sulfate (Condrosulf) | 2.5 |
| Placebo | 0.6 |
Change in morning stiffness duration calculated as the difference between the month 6 value and the baseline value (NCT00291499)
Timeframe: 6 months
| Intervention | minutes (Mean) |
|---|---|
| Chondroitin 4&6 Sulfate (Condrosulf) | -4.8 |
| Placebo | 0.3 |
Total consumption (between ^baseline and month 6) of paracetamol (500 mg tablets) reported by the patients on a daily diary (NCT00291499)
Timeframe: 6 months
| Intervention | tablets/week (Mean) |
|---|---|
| Chondroitin 4&6 Sulfate (Condrosulf) | 1.9 |
| Placebo | 2.0 |
Number of participants with Maximum pain intensity NVS > 3; Rescue analgesia; Nausea and Vomiting incidence; use of ondansetron for NVPO; Ondansetron being effective (number of participants for whom ondansetron was effective to stop NVPO). (NCT01597479)
Timeframe: Up to 48 hours
| Intervention | participants (Number) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Maximum pain intensity 24h (NVS>3) | Maximum pain intensity 48h (NVS >3) | Rescue analgesia 24h (n) | Rescue Analgesia 48h (n) | Nausea and vomiting 24h (n) | Nausea and vomiting 48h (n) | Use of ondansetron 24h (n) | Use of ondansetron 48h (n) | Effectiveness of ondansetron 24h | Efectiveness of ondansetron 48h | |
| dPNBs Group | 8 | 5 | 2 | 5 | 1 | 0 | 1 | 0 | 1 | 0 |
| Non dPNBs Group | 24 | 21 | 17 | 17 | 10 | 5 | 5 | 5 | 4 | 2 |
Pain scores assessed using pain numerical visual scale (NVS) of 0-10 (o= no pain and 10= worst pain imaginable). We defined mild pain (NVS 0-3); moderate pain (NVS 4-6) and severe pain (NVS 7-10).The analysis of this variable at the end of the study will confirm or not the effectiveness of dPNBs for management of postoperative pain after TRA. (NCT01597479)
Timeframe: Up to 48 hours
| Intervention | percentage of patients (Number) | |
|---|---|---|
| Pain intensity NVS>3 on call 24h | Pain intensity NVS>3 on call 48h | |
| Distal Peripheral Nerve Blocks Group (dPNBs Group) | 8.3 | 4.2 |
| Non Distal Peripheral Nerve Blocks (Non dPNBs Group) | 80.8 | 42.3 |
74 reviews available for acetaminophen and Osteoarthritis
| Article | Year |
|---|---|
Relative safety and efficacy of topical and oral NSAIDs in the treatment of osteoarthritis: A systematic review and meta-analysis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Pain; Quality of Lif | 2022 |
Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Cohort Studies; COVID-19; COVID-1 | 2023 |
Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis.
Topics: Acetaminophen; Cartilage, Articular; Humans; Inflammation; Macrophages; Osteoarthritis | 2023 |
Systemic drugs with impact on osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin | 2019 |
Osteoarthritis year in review 2019: epidemiology and therapy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2020 |
Pharmacotherapeutic considerations and options for the management of osteoarthritis in women.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; | 2020 |
The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Case-Control Studies; Craniotomy; Data Management; Humans; | 2021 |
Treating osteoarthritis pain: mechanisms of action of acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, and nerve growth factor antibodies.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2021 |
NSAIDs are superior to paracetamol for osteoarthritic pain and function in a network meta-analysis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Network Me | 2018 |
Pharmacological Treatment of Pain in Osteoarthritis: A Descriptive Review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2018 |
Safety of Paracetamol in Osteoarthritis: What Does the Literature Say?
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthralgia; Chemical and Drug Induced Liver Injury; D | 2019 |
Evidence-Based Recommendations on the Pharmacological Management of Osteoarthritis and Chronic Low Back Pain: An Asian Consensus
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidep | 2019 |
The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: a systematic literature review and meta-analysis.
Topics: Acetaminophen; Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bayes Theo | 2014 |
Drugs for osteoarthritis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat | 2014 |
Safety and efficacy of paracetamol and NSAIDs in osteoarthritis: which drug to recommend?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2015 |
Controversy: hirudotherapy (leech therapy) as an alternative treatment for osteoarthritis.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Complementary Therapies; Humans; Indon | 2015 |
Safely Managing Acute Osteoarthritis in the Emergency Department: An Evidence-Based Review.
Topics: Acetaminophen; Acute Disease; Administration, Cutaneous; Administration, Oral; Adrenal Cortex Hormon | 2016 |
Move it or Lose it. Is it Reasonable for Older Adults with Osteoarthritis to Continue to Use Paracetamol in Order to Maintain Physical Activity?
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Exercise; Humans; Medication Adherence; Motor Activit | 2017 |
Inflammation and shoulder pain--a perspective on rotator cuff disease, adhesive capsulitis, and osteoarthritis: conservative treatment.
Topics: Acetaminophen; Administration, Oral; Adrenal Cortex Hormones; Analgesics, Opioid; Animals; Anti-Infl | 2009 |
NSAIDs.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Dose | 2007 |
The role of acetaminophen in the treatment of osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents | 2010 |
[Osteoarthritis - which approach is evidence based?].
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Ulcer Agents; Antirheumatic Agents; Cyclooxygena | 2010 |
Osteoarthritis: a review of treatment options.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Outcome measures in placebo-controlled trials of osteoarthritis: responsiveness to treatment effects in the REPORT database.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2011 |
Treatment options for osteoarthritis: considerations for older adults.
Topics: Acetaminophen; Aged; Algorithms; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Stero | 2011 |
NSAIDs.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Huma | 2010 |
The NSAID dilemma: managing osteoarthritis in high-risk patients.
Topics: Acetaminophen; Administration, Oral; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analge | 2011 |
Pharmaceutical therapy for osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 I | 2012 |
[Antiinflammatory therapy in ostheoarthritis including omega 3 and omega 6 fatty acids].
Topics: Acetaminophen; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin Sulfat | 2012 |
Management of osteoarthritis of the knee.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat | 2012 |
Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioid analgesics.
Topics: Acetaminophen; Age Factors; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Ag | 2012 |
[Medication a complement to other forms of pain management in osteoarthritis].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agen | 2002 |
Pharmacologic therapy for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dietary Supplemen | 2002 |
New directions in symptomatic therapy for patients with osteoarthritis and rheumatoid arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase 2; Cyc | 2002 |
Treating osteoarthritis pain.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitor | 2003 |
Acetaminophen for osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2003 |
[Paracetamol in the treatment of osteoarthritis pain].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg | 2003 |
Translating research into practice: acetaminophen in osteoarthritis revisited.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Pain | 2004 |
Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Patient Satisfaction; Randomized Co | 2004 |
[Treatment for inflammation related pain--COX-2 inhibitors knocking on the door].
Topics: Acetaminophen; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; Ibupr | 2004 |
Clinical inquiries. Does acetaminophen and NSAID combined relieve osteoarthritis pain better than either alone?
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Evidence-Based Me | 2004 |
Acetaminophen as symptomatic treatment of pain from osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Controlled Clinica | 2004 |
New developments in osteoarthritis.
Topics: Acetaminophen; Acupuncture Therapy; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non | 2005 |
[Conservative therapy of arthritis].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Chondr | 2005 |
Symptomatic treatment of osteoarthritis: paracetamol or NSAIDs?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2004 |
Osteoarthritis.
Topics: Acetaminophen; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Bone Remodeling; Cartilage, Art | 2005 |
The use of opioids in the treatment of osteoarthritis: when, why, and how?
Topics: Acetaminophen; Acupuncture Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammator | 2005 |
Acetaminophen for osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2006 |
Acetaminophen or NSAIDs for the treatment of osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2006 |
Tramadol for osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Randomized Controlled Trials as Top | 2006 |
Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Black or African A | 2006 |
Pharmacotherapy of osteoarthritis.
Topics: Acetaminophen; Administration, Topical; Analgesics; Anesthetics, Local; Capsaicin; Delayed-Action Pr | 2006 |
Tramadol for osteoarthritis: a systematic review and metaanalysis.
Topics: Acetaminophen; Analgesics, Opioid; Drug Therapy, Combination; Humans; Osteoarthritis; Pain; Pain Mea | 2007 |
COX-2 selective inhibitors in the treatment of osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cycl | 2008 |
Treating the symptoms of osteoarthritis-oral treatments.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory | 2008 |
Review of ibuprofen for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Toleran | 1984 |
Practical management of osteoarthritis. Integration of pharmacologic and nonpharmacologic measures.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Codeine; Dext | 1995 |
Should osteoarthritis be treated with nonsteroidal anti-inflammatory drugs?
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Drug Costs | 1993 |
[Anti-inflammatory and analgesic treatment of osteoarthritis].
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Humans; In | 1996 |
Use of carprofen for the treatment of pain and inflammation in dogs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
Non-NSAID pharmacologic treatment options for the management of chronic pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1998 |
Osteoarthritis pain and its treatment.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthro | 2000 |
Role of intra-articular hyaluronic acid preparations in medical management of osteoarthritis of the knee.
Topics: Acetaminophen; Administration, Topical; Adrenal Cortex Hormones; Analgesics; Analgesics, Non-Narcoti | 2000 |
Treatment of osteoarthritis with acetaminophen: efficacy, safety, and comparison with nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Controlled Clinical Trials as Topic; Dose-Re | 2000 |
Nonsteroidal anti-inflammatory drugs: overused or underused in osteoarthritis?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Prescriptions | 2001 |
The role of acetaminophen in the management of patients with osteoarthritis.
Topics: Acetaminophen; Activities of Daily Living; Age Distribution; Aged; Analgesics, Non-Narcotic; Anti-In | 2001 |
Osteoarthritis management: the role of cyclooxygenase-2-selective inhibitors.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2001 |
The role of analgesics in the management of osteoarthritis pain.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Human | 2000 |
Treatment of chronic pain in osteoarthritis: do opioids have a clinical role?
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Opioid-Related D | 2001 |
Clinical evidence for osteoarthritis as an inflammatory disease.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Combinations; Humans | 2001 |
Osteoarthritis--a review.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Exerci | 2002 |
Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesia; Cardiovascular System; Celecoxib; Clinical Trials as Topic; Cyclooxygenase | 2002 |
[Osteoarthritis. Pathogenesis, clinical features and treatment].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, | 2002 |
Ibuprofen. A review.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials | 1971 |
60 trials available for acetaminophen and Osteoarthritis
| Article | Year |
|---|---|
Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up.
Topics: Acetaminophen; Double-Blind Method; Female; Follow-Up Studies; Humans; Injections, Intra-Articular; | 2022 |
A cluster randomized trial to measure the impact on nonsteroidal anti-inflammatory drug and proton pump inhibitor prescribing in Italy of distributing cost-free paracetamol to osteoarthritic patients.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2019 |
Effect of effervescent paracetamol on blood pressure: a crossover randomized clinical trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Antihypertensive Agents; Blood Pressure; Blood Pressu | 2018 |
Patient preferences for adherence to treatment for osteoarthritis: the MEdication Decisions in Osteoarthritis Study (MEDOS).
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Choice Behavior; Female; Glucosa | 2013 |
Interaction between antihypertensives and NSAIDs in primary care: a controlled trial.
Topics: Acetaminophen; Aged; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; B | 2008 |
A randomized, multicentric, comparative evaluation of aceclofenac-paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up.
Topics: Acetaminophen; Adult; Aged; Diclofenac; Drug Therapy, Combination; Female; Humans; India; Male; Midd | 2009 |
Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2009 |
Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial.
Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dietary Supplements | 2009 |
Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chronic Diseas | 2010 |
[Merits of paracetamol in osteoarthritic hypertensive patients].
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Antihypertensive Agents; Blood Pre | 2011 |
No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Double-Blind Method; Facial Pain; Fem | 2011 |
A randomized, 14-day, double-blind study evaluating conversion from hydrocodone/acetaminophen (Vicodin) to buprenorphine transdermal system 10 μg/h or 20 μg/h in patients with osteoarthritis pain.
Topics: Acetaminophen; Administration, Cutaneous; Administration, Oral; Aged; Analgesics, Opioid; Anti-Infla | 2012 |
Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; | 2004 |
Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2004 |
Continuous low-level heat wrap therapy is effective for treating wrist pain.
Topics: Acetaminophen; Activities of Daily Living; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bandag | 2004 |
Trial of tramadol/acetaminophen tablets for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2005 |
Using n-of-1 trials as a clinical tool to improve prescribing.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Attention Deficit Disorder with Hy | 2005 |
Impact of a general practitioner educational intervention on osteoarthritis treatment in an elderly population.
Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; | 2005 |
Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N | 2007 |
Three-month efficacy and safety of acetaminophen extended-release for osteoarthritis pain of the hip or knee: a randomized, double-blind, placebo-controlled study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Double-Blind Method; Female | 2007 |
Transcutaneous electrical nerve stimulation in osteoarthrosis: a therapeutic alternative?
Topics: Acetaminophen; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Electric Stimulation Ther | 1984 |
Review of ibuprofen for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Toleran | 1984 |
Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Combinations; Humans; Metoclopr | 1983 |
A comparison of three ways of measuring pain.
Topics: Acetaminophen; Aged; Apazone; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomet | 1982 |
An articular index for the assessment of osteoarthritis.
Topics: Acetaminophen; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Method; Drug Combinations; | 1981 |
Analgesic properties of fluproquazone.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Dextropropo | 1982 |
Histological study of the effects of three anti-inflammatory preparations on the gastric mucosa.
Topics: Acetaminophen; Acute Disease; Adult; Anti-Inflammatory Agents; Chronic Disease; Dextropropoxyphene; | 1981 |
Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis.
Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relat | 1994 |
Intra-articular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug | 1994 |
n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesia; Capsules; Diclofenac; Double-Blind Method; | 1994 |
The effect of folate and cobalamin on osteoarthritic hands.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Double-Blind Method; Fol | 1994 |
Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Arthrography; Double-Blind Method; Female; Humans; Kn | 1993 |
Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin | 1996 |
Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin | 1996 |
Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin | 1996 |
Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin | 1996 |
[Analgesic effect and clinical tolerability of the combination of paracetamol 500 mg and caffeine 50 mg versus paracetamol 400 mg and dextropropoxyphene 30 mg in back pain].
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Back Pa | 1996 |
Floctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs. Franco-Belgian Task Force.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross | 1997 |
Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-In | 1999 |
Preliminary experiences with a single-patient trials service in general practice.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N | 2000 |
[Postoperative pain and surgical treatment of trapeziometacarpal osteoarthritis of the thumb after ambulatory surgery].
Topics: Acetaminophen; Aged; Ambulatory Surgical Procedures; Analgesics; Anti-Inflammatory Agents, Non-Stero | 2000 |
Educational program for physicians to reduce use of non-steroidal anti-inflammatory drugs among community-dwelling elderly persons: a randomized controlled trial.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Utilization; Education, Medical, | 2001 |
Educational program for nursing home physicians and staff to reduce use of non-steroidal anti-inflammatory drugs among nursing home residents: a randomized controlled trial.
Topics: Acetaminophen; Aged; Aged, 80 and over; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Decisio | 2001 |
Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Respon | 2002 |
Comparative study of salsalate and aspirin in osteoarthrosis of the hip or knee.
Topics: Acetaminophen; Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; | 1978 |
Successful use of a moderate analgesic (Fortagesic) in the symptomatic treatment of osteoarthritis.
Topics: Acetaminophen; Drug Combinations; Female; Humans; Male; Naproxen; Osteoarthritis; Pentazocine | 1979 |
A clinical Trial of Tofranil in osteo-arthritis.
Topics: Acetaminophen; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; Imipram | 1976 |
A trial of Fortagesic and Paramol 118 in osteoarthritis.
Topics: Acetaminophen; Codeine; Drug Combinations; Humans; Osteoarthritis; Pentazocine | 1976 |
Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic.
Topics: Acetaminophen; Adult; Aged; Analysis of Variance; Dose-Response Relationship, Drug; Double-Blind Met | 1992 |
Acceptability and efficacy of two associations of paracetamol with a central analgesic (dextropropoxyphene or codeine): comparison in osteoarthritis.
Topics: Acetaminophen; Aged; Capsules; Codeine; Dextropropoxyphene; Double-Blind Method; Drug Combinations; | 1992 |
Comparative clinical evaluation of the activity of Ser-316 suppository in the treatment of lumbar osteoarthrosis.
Topics: Acetaminophen; Activities of Daily Living; Double-Blind Method; Female; Follow-Up Studies; Humans; I | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study.
Topics: Acetaminophen; Aged; Chronic Disease; Codeine; Double-Blind Method; Drug Combinations; Hip Joint; Hu | 1990 |
A method for comparing analgesics: glafenine and paracetamol. Multicenter cross-over approach.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Double-Blind Method; Glafenine; Hip Joint; Humans; Kn | 1988 |
Comparison of a standard ibuprofen treatment regimen with a new ibuprofen/paracetamol/codeine combination in chronic osteo-arthritis.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Codeine; Double-Blind Metho | 1987 |
[Treatment of the diseases of the extended rheumatic sphere form with paracetamol (Dolo-arthrosetten)].
Topics: Acetaminophen; Anti-Inflammatory Agents; Back Pain; Cartilage Diseases; Drug Therapy, Combination; H | 1973 |
Fenoprofen in the treatment of osteoarthrosis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Humans; Osteoarthritis; Pain; Phenyl Ethers; Phenylbutazone | 1974 |
'Safapryn' and benorylate--a comparative trial of two new preparations of aspirin and paracetamol in the treatment of rheumatoid arthritis and osteoarthritis.
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Combinations; Drug Eva | 1973 |
Fenoprofen in treatment of osteoarthrosis of hip and knee.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Clinical Trials as Topic; Drug Evaluation; Fema | 1974 |
Orudis in the management of osteo-arthritis of the knee. A double-blind trial.
Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; | 1974 |
The analgesic properties of chlorphenesin carbamate in the treatment of osteoarthrosis. Report of a trial.
Topics: Acetaminophen; Aged; Analgesics; Chlorphenesin; Clinical Trials as Topic; Female; Hip Joint; Humans; | 1968 |
Ibuprofen. A review.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials | 1971 |
An assessment of "Fiorinal" and FIPA in painful conditions of the hands.
Topics: Acetaminophen; Adult; Aged; Analgesics; Analysis of Variance; Arthritis, Rheumatoid; Aspirin; Caffei | 1970 |
96 other studies available for acetaminophen and Osteoarthritis
| Article | Year |
|---|---|
Paracetamol Use in Patients With Osteoarthritis and Lower Back Pain: Infodemiology Study and Observational Analysis of Electronic Medical Record Data.
Topics: Acetaminophen; Adult; Electronic Health Records; Female; Humans; Infodemiology; Low Back Pain; Male; | 2022 |
Why are we still using opioids for osteoarthritis?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2020 |
Osteoarthritis in Older Adults: Nonsteroidal Anti-Inflammatory Drugs Versus Opioids.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2019 |
Drugs for osteoarthritis.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Duloxetine Hydrochloride | 2020 |
Initial analgesic prescriptions for osteoarthritis in the United Kingdom, 2000-2016.
Topics: Acetaminophen; Administration, Cutaneous; Administration, Oral; Aged; Analgesics; Analgesics, Opioid | 2021 |
Nonsteroidal Antiinflammatory Drugs and Susceptibility to COVID-19.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; | 2021 |
Naproxen treatment inhibits articular cartilage loss in a rat model of osteoarthritis.
Topics: Acetaminophen; Animals; Cartilage, Articular; Disease Models, Animal; Female; Naproxen; Osteoarthrit | 2021 |
Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Meta-Analysis as Topic; Osteoarthrit | 2021 |
Regular use of acetaminophen or acetaminophen-codeine combinations and prescription of rescue therapy with non-steroidal anti-inflammatory drugs: a population-based study in primary care.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Coh | 2017 |
Prevalence and changes in analgesic medication utilisation 1 year prior to total joint replacement in an older cohort of patients.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, No | 2018 |
Analgesic Use and Risk for Acute Coronary Events in Patients With Osteoarthritis: A Population-based, Nested Case-control Study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Angina, Unstable; Ant | 2018 |
Analgesic prescribing trends in a national sample of older veterans with osteoarthritis: 2012-2017.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Age | 2019 |
Increasing Participation in Daily Activities among US Adults with Arthritis.
Topics: Acetaminophen; Activities of Daily Living; Aged; Analgesics, Non-Narcotic; Arthralgia; Exercise; Fem | 2019 |
Analgesics for osteoarthritis.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Gastroi | 2013 |
Pharmacologic treatment of hand-, knee- and hip-osteoarthritis.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adrenal Cortex Hormones; Analgesics; A | 2013 |
Managing osteoarthritis pain in the older population.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Age Factors; Aged; Aging; Analgesics, | 2013 |
The therapeutic management of chronic pain in ambulatory care patients aged 65 and over in France: the S.AGES Cohort. Baseline data.
Topics: Acetaminophen; Aged; Aged, 80 and over; Ambulatory Care; Analgesics; Back Pain; Chronic Pain; Dextro | 2013 |
How safe is acetaminophen in rheumatology?
Topics: Acetaminophen; Cardiovascular Diseases; Chronic Pain; Humans; Musculoskeletal Pain; Osteoarthritis; | 2014 |
NICE keeps paracetamol in UK guidelines on osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Practice Guidelines as Topic; Unite | 2014 |
Exercise stays central to treatment of osteoarthritis in latest advice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Exercise; Humans; Osteoarthritis; Practice Guidelines as To | 2014 |
Pilot open observations on doxycycline treatment for erosive osteoarthritis of the hand.
Topics: Acetaminophen; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Doxycycli | 2015 |
Managing back pain and osteoarthritis without paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Back Pain; Humans; Osteoarthritis | 2015 |
Study findings on acetaminophen at odds with clinical guidelines.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Osteoarthritis; Practice Guidelines | 2015 |
Response to: 'Paracetamol: is all the concern valid?' by Schwarz and Mullins.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2015 |
NSAIDs or paracetamol for short-term treatment of mild to moderate knee pain in early osteoarthritis: are they equivalent?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthr | 2016 |
Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study.
Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Dise | 2015 |
Have osteoarthritis? Careful with narcotic painkillers.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Humans; Narcotics; Osteoarthritis | 2013 |
Prescription usage patterns of two formulations of paracetamol in osteoarthritis: Australia-wide experience 2008-11.
Topics: Acetaminophen; Aged; Aged, 80 and over; Australia; Delayed-Action Preparations; Drug Compounding; Fe | 2016 |
Satisfaction, Adherence and Health-Related Quality of Life with Transdermal Buprenorphine Compared with Oral Opioid Medications in the Usual Care of Osteoarthritis Pain.
Topics: Acetaminophen; Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Anal | 2016 |
Acetaminophen in Perspective.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthralgia; Female; Humans; Male; Osteoarthritis; Tre | 2016 |
Managing back pain and osteoarthritis without paracetamol: Physical treatments are the way forward.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Back Pain; Humans; Osteoarthritis; Pain Management | 2016 |
Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antirheumatic Agents; Biomarkers; Cartilage Oligomeric Matr | 2018 |
GP management of osteoarthritic pain in Hong Kong.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Sectional St | 2008 |
Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N | 2009 |
Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N | 2009 |
Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N | 2009 |
Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N | 2009 |
Use of recommended osteoarthritis pain treatment by older adults.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2009 |
Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dis | 2009 |
Blood pressure destabilization on nonsteroidal antiinflammatory agents: acetaminophen exposed?
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiovascular Diseases; Dos | 2010 |
"It looks after me": how older patients make decisions about analgesics for osteoarthritis.
Topics: Acetaminophen; Age Factors; Aged; Aged, 80 and over; Aging; Analgesics, Non-Narcotic; Anti-Inflammat | 2011 |
Flavocoxid inhibits phospholipase A2, peroxidase moieties of the cyclooxygenases (COX), and 5-lipoxygenase, modifies COX-2 gene expression, and acts as an antioxidant.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonate 5-Lipoxy | 2011 |
Therapy switching, augmentation, and discontinuation in patients with osteoarthritis and chronic low back pain.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-In | 2012 |
Older adult osteoarthritis pain management: results from the 2008 National Ambulatory Medical Care Survey.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Combined Modality Therapy; Comorbidity | 2012 |
Older adults living with osteoarthritis: examining the relationship of age and gender to medicine use.
Topics: Acetaminophen; Age Factors; Aged; Analgesics, Opioid; Analysis of Variance; Anti-Inflammatory Agents | 2012 |
Factors predicting older adults' use of exercise and acetaminophen for osteoarthritis pain.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Case-Control | 2012 |
Effect of acetaminophen and nonsteroidal anti-inflammatory drugs on gene expression of mesenchymal stem cells.
Topics: Acetaminophen; Aged; Aged, 80 and over; Aggrecans; Alkaline Phosphatase; Anti-Inflammatory Agents, N | 2013 |
Key questions concerning paracetamol and NSAIDs for osteoarthritis.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Analgesics, Non-Narcotic; Anti-Inflamm | 2002 |
Et tu, acetaminophen?
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygena | 2002 |
Published meta-analyses of pharmacological therapies for osteoarthritis.
Topics: Acetaminophen; Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chondroi | 2002 |
Key questions concerning paracetamol and NSAIDs for OA.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; I | 2003 |
DEGENERATIVE JOINT DISEASES--DISCS AND OSTEOARTHRITIS. II. DIAGNOSIS AND MANAGEMENT OF OSTEOARTHRITIS.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Diagnosis, Differential; | 1963 |
Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dose-R | 2003 |
Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis | 2003 |
Serious gastrointestinal events from low dose analgesic use.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dose-Respons | 2004 |
A 64 year old woman with knee pain: case outcome.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Decision Making; Drug Interactions; Femal | 2004 |
A historic issue of the Annals: three papers examine paracetamol in osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Randomized Controlled Trials as Top | 2004 |
NSAID alternatives.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase Inhibi | 2005 |
Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis.
Topics: Acetaminophen; Age Factors; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Human | 2005 |
Acetaminophen may act through beta endorphin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; beta-Endorphin; Humans; Osteoarthritis | 2005 |
Opioids for non-operable osteoarthritis and soft-tissue rheumatism.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, | 2005 |
Australia: the N of 1 trial, an underappreciated research method.
Topics: Acetaminophen; Aged; Attention Deficit Disorder with Hyperactivity; Australia; Child; Child, Prescho | 2006 |
Paracetamol should be first-line therapy in osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Osteoarthritis; Practice Guidelines as Topic; Treat | 2005 |
The effect of cyclooxygenase-2 inhibitors on bone mineral density: results from the Canadian Multicentre Osteoporosis Study.
Topics: Acetaminophen; Adult; Aged; Body Mass Index; Bone Density; Cyclooxygenase 2 Inhibitors; Dose-Respons | 2006 |
NSAIDs better than acetaminophen for mild-to-moderate OA pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Humans | 2006 |
Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; | 2006 |
Conducting research in individual patients: lessons learnt from two series of N-of-1 trials.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Rela | 2006 |
Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Analgesics, Non-Narcotic; Aspar | 2006 |
Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Analgesics, Non-Narcotic; Aspar | 2006 |
Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Analgesics, Non-Narcotic; Aspar | 2006 |
Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Analgesics, Non-Narcotic; Aspar | 2006 |
Advice for nurses on drug withdrawal.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Australia; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Ap | 2007 |
Pain and inflammation.
Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Humans; Osteoarthritis; Pai | 1984 |
Further look at dextropropoxyphene with or without paracetamol in the treatment of arthritis.
Topics: Acetaminophen; Arthritis, Rheumatoid; Dextropropoxyphene; Double-Blind Method; Drug Combinations; Dr | 1984 |
n of 1 trials in osteoarthritis. Study was conceptually and statistically biased.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Bias; Humans; Osteoarthritis; Randomized Con | 1995 |
n of 1 trials in osteoarthritis. Caution in interpretation needed.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Data Interpretation, Statistical; Humans; Os | 1995 |
Treatment for non-inflammatory arthritis.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis | 1994 |
Simple analgesics versus NSAIDs for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Treatment Outcome | 1993 |
Osteoarthritis treatment update. Minimizing pain while limiting patient risk.
Topics: Acetaminophen; Administration, Topical; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Stero | 1993 |
Osteoarthritis: new roles for drug therapy and surgery. Interview by Peter Pompei.
Topics: Acetaminophen; Activities of Daily Living; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, | 1996 |
North of England evidence based guideline development project: summary guideline for non-steroidal anti-inflammatory drugs versus basic analgesia in treating the pain of degenerative arthritis. The North of England Non-Steroidal Anti-Inflammatory Drug Gui
Topics: Acetaminophen; Activities of Daily Living; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Codei | 1998 |
When joints--and costs--become inflamed.
Topics: Acetaminophen; Adrenal Cortex Hormones; Arthroplasty, Replacement; Cost of Illness; Health Care Cost | 1997 |
Preference for nonsteroidal antiinflammatory drugs over acetaminophen by rheumatic disease patients: a survey of 1,799 patients with osteoarthritis, rheumatoid arthritis, and fibromyalgia.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Fibromy | 2000 |
Preference for nonsteroidal antiinflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Data Collect | 2000 |
Tempering the enthusiasm for COX-2 inhibitors.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cycloox | 2000 |
Economic evaluation alongside n-of-1 trials: getting closer to the margin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; C | 2001 |
Treatment of osteoarthritic pain: systemic drug therapy is not always necessary.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Human | 2000 |
Quality indicators for the management of osteoarthritis in vulnerable elders.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2001 |
Rofecoxib vs celecoxib vs acetaminophen for treatment of osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cycloox | 2002 |
Rofecoxib vs celecoxib vs acetaminophen for treatment of osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cycloox | 2002 |
Trends in medication use for osteoarthritis treatment.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Drug Utilization; | 2002 |
The absorption of Safapryn in patients with arthritis.
Topics: Acetaminophen; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Drug Combinations; Female; Humans; Intes | 1976 |
Treatment options for a patient with osteoarthritis and a history of ulcer disease.
Topics: Acetaminophen; Administration, Oral; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Comb | 1991 |
Medical therapy of osteoarthritis of the knee.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Humans; Knee Joint; Osteoarthritis | 1991 |
Cartilage degradative enzymes in human osteoarthritis: effect of a nonsteroidal antiinflammatory drug administered orally.
Topics: Acetaminophen; Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Artic | 1990 |
Simple analgesics preferable to NSAIDs for the elderly.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Pa | 1990 |
Controlled-release ketoprofen in rheumatoid arthritis and osteoarthritis: comparison of two doses in Thailand.
Topics: Acetaminophen; Adult; Aged; Arthritis, Rheumatoid; Delayed-Action Preparations; Female; Humans; Keto | 1988 |
Osteoarthritis: increasing mobility and reducing disability.
Topics: Acetaminophen; Adrenal Cortex Hormones; Aged; Ankle Joint; Anti-Inflammatory Agents; Aspirin; Cervic | 1986 |
Aspirin and the kidney. New Zealand Rheumatism Association Study.
Topics: Acetaminophen; Adult; Arthritis, Rheumatoid; Aspirin; Caffeine; Codeine; Drug Synergism; Female; Hum | 1974 |
[The association of paracetamol and phenylbutazone in rheumatology. Preliminary report].
Topics: Acetaminophen; Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child; Female; Fibromyalgia; Humans; | 1966 |
Comparison of flufenamic acid with aspirin and paracetamol in terms of gastrointestinal blood loss.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chromium Isotopes; Fe | 1966 |
[On the two-phase therapy of degenerative rheumatism with a myotonolytic-antiphlogistic and an analgesic combination preparation].
Topics: Acetaminophen; Adult; Aged; Benzoxazoles; Chlorzoxazone; Female; Humans; Male; Middle Aged; Muscles; | 1968 |