acetaminophen has been researched along with Obesity in 39 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen is used by the majority of pregnant women, and some continue to use for many weeks in pregnancy." | 7.96 | Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort. ( Bandoli, G; Chambers, C; Palmsten, K, 2020) |
| " Acetaminophen treatment decreased renal lipid deposition, ER-stress related signaling, apoptosis and albuminuria." | 7.80 | Acetaminophen attenuates obesity-related renal injury through ER-mediated stress mechanisms. ( Arvapalli, R; Blough, E; Dai, X; Driscoll, H; Mahmood, M; Rice, KM; Wang, C; Wu, M, 2014) |
| "The effect of genetic obesity and phenobarbital treatment on hepatic conjugation pathways was evaluated in the obese Zucker rat." | 7.68 | Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways. ( Blouin, RA; Chaudhary, IP; McNamara, PJ; Robertson, LW; Tuntaterdtum, S, 1993) |
| "The overfed rat served as the animal model for examining the influence of obesity on the hepatotoxic and nephrotoxic potential of metabolically activated drugs, and acetaminophen served as the prototype drug." | 7.67 | Obesity as a risk factor in drug-induced organ injury: increased liver and kidney damage by acetaminophen in the obese overfed rat. ( Corcoran, GB; Wong, BK, 1987) |
| "The influence of obesity on the distribution or clearance of lorazepam and oxazepam, two benzodiazepines biotransformed by glucuronide conjugation, was studied in a series of obese subjects (mean weight 113 kg; mean percent IBW 179%) and healthy controls of normal body habitus matched for age and sex." | 7.66 | Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam, and acetaminophen. ( Abernethy, DR; Divoll, M; Greenblatt, DJ; Shader, RI, 1983) |
| " The half-life was the same in the obese patients (2." | 5.26 | The effect of obesity on acetaminophen pharmacokinetics in man. ( Granville, GE; Kramer, WG; Lee, WH, 1981) |
| " Despite abundant experimental data showing that fatty liver is more susceptible to liver injury, drug-induced liver disease seems no more frequent in NAFLD patients, except, possibly, a higher incidence but not severity of acetaminophen hepatotoxicity." | 4.90 | The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease. ( Pais, R; Ratziu, V; Rusu, E, 2014) |
| "001), and AUC insulin and leptin were higher in the obesity vs." | 4.12 | Time of day differences in appetite and gut hormone responses to meal and stress challenges in adults with normal-weight and obesity. ( Carnell, S; Ellis, S; Geliebter, A; Grillot, CL; Holst, JJ; Mehta, N; Papantoni, A; Ungredda, T, 2022) |
| "Acetaminophen is used by the majority of pregnant women, and some continue to use for many weeks in pregnancy." | 3.96 | Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort. ( Bandoli, G; Chambers, C; Palmsten, K, 2020) |
| "WLS, which has increased in proportion to the global rise of obesity, alters the absorption and metabolism of many drugs including acetaminophen (APAP) and may predispose to toxicity." | 3.81 | Acute Liver Failure Due to Acetaminophen Poisoning in Patients With Prior Weight Loss Surgery: A Case Series. ( Davern, TJ; DeMartini, S; Holt, EW, 2015) |
| " Acetaminophen treatment decreased renal lipid deposition, ER-stress related signaling, apoptosis and albuminuria." | 3.80 | Acetaminophen attenuates obesity-related renal injury through ER-mediated stress mechanisms. ( Arvapalli, R; Blough, E; Dai, X; Driscoll, H; Mahmood, M; Rice, KM; Wang, C; Wu, M, 2014) |
| "Clinical investigations suggest that hepatotoxicity after acetaminophen (APAP) overdose could be more severe in the context of obesity and nonalcoholic fatty liver disease." | 3.78 | Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. ( Aubert, J; Begriche, K; Delannoy, M; Fromenty, B; Jaeschke, H; Lepage, S; Lucas-Clerc, C; McGill, MR; Morel, I; Pajaud, J; Ribault, C; Robin, MA; Turlin, B, 2012) |
| " Multivariable logistic regression analyses showed the region of residence, being born in Canada, recent use of acetaminophen and heavy exposure to traffic exhaust were significantly associated with all three allergic conditions, while obesity and having two or more smokers at home was only associated with increased risk for wheezing." | 3.76 | Disparate geographic prevalences of asthma, allergic rhinoconjunctivitis and atopic eczema among adolescents in five Canadian cities. ( Becker, AB; Duncan, JM; Ferguson, AC; Greene, JM; Pizzichini, MM; Rennie, DC; Sears, MR; Senthilselvan, A; Taylor, BW; Wang, HY, 2010) |
| "The effect of genetic obesity and phenobarbital treatment on hepatic conjugation pathways was evaluated in the obese Zucker rat." | 3.68 | Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways. ( Blouin, RA; Chaudhary, IP; McNamara, PJ; Robertson, LW; Tuntaterdtum, S, 1993) |
| " The entire spectrum of alcoholic liver disease, including alcoholic hepatitis, may be perfectly mimicked by severe obesity, diabetes, and perhexiline maleate toxicity." | 3.67 | Problems in the necropsy diagnosis of alcoholic liver disease. ( Pounder, DJ, 1984) |
| "Intravenous acetaminophen is commonly administered as an adjunctive to opioids during major surgical procedures, but neither the correct pharmacokinetic size descriptor nor the dose is certain in severely obese adolescents undergoing bariatric surgery." | 2.90 | Acetaminophen pharmacokinetics in severely obese adolescents and young adults. ( Anderson, BJ; Hakim, M; Michalsky, MP; Syed, A; Tobias, JD; Tumin, D; Walia, H, 2019) |
| " There was a significant inverse dose-response (p-trend <0." | 2.49 | Aspirin, nonsteroidal anti-inflammatory drugs, paracetamol and risk of endometrial cancer: a case-control study, systematic review and meta-analysis. ( Nagle, CM; Neill, AS; Obermair, A; Protani, MM; Spurdle, AB; Webb, PM, 2013) |
| "Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease and its influence on drug-induced liver injury (DILI) is not fully understood." | 1.91 | Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model. ( Clayton, NP; Cortes, RA; Izawa, T; Pandiri, AR; Sills, RC; Travlos, GS, 2023) |
| "Acetaminophen is a commonly used analgesic and antipyretic, with the potential to cause significant injury when ingested in toxic amounts." | 1.62 | Evaluation of Dosing Strategies of N-acetylcysteine for Acetaminophen Toxicity in Patients Greater than 100 Kilograms: Should the Dosage Cap Be Used? ( Akpunonu, P; Bailey, AM; Baum, RA; Geraghty, L; Howell, MM; Mohan, S; Su, MK; Weant, KA; Webb, AN; Woolum, JA, 2021) |
| "Although obesity is increasing worldwide, experimental studies examining the possible association between obesity and susceptibility to chemical toxicity are limited." | 1.48 | A 13-week subchronic toxicity study of acetaminophen using an obese rat model. ( Akagi, JI; Cho, YM; Imaida, K; Matsushita, K; Mizuta, Y; Nishikawa, A; Ogawa, K; Toyoda, T, 2018) |
| " In C57BL/6J mice, streptozotocin caused a dosage dependent increase in fasting blood glucose (FBG), from 100 to >600mg/dl." | 1.35 | Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. ( Clegg, DJ; D'Alessio, DA; Genter, MB; Kendig, EL; Schneider, SN; Shertzer, HG, 2008) |
| "The etiology of the hyperphagia is unknown, but eating behaviors and gastrointestinal motility could play a pivotal role." | 1.34 | Eating behavior and gastric emptying in adults with Prader-Willi syndrome. ( Barkeling, B; Hellstrom, PM; Hoybye, C; Naslund, E; Thorén, M, 2007) |
| "Obesity was produced in Sprague-Dawley rats with an energy-dense cafeteria feeding regimen." | 1.27 | Acetaminophen sulfation deficit in obese rats overfed an energy-dense cafeteria diet. ( Corcoran, GB; Galinsky, RE; Shum, L; Wong, BK, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (20.51) | 18.7374 |
| 1990's | 3 (7.69) | 18.2507 |
| 2000's | 7 (17.95) | 29.6817 |
| 2010's | 15 (38.46) | 24.3611 |
| 2020's | 6 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Carnell, S | 1 |
| Papantoni, A | 1 |
| Grillot, CL | 1 |
| Ungredda, T | 1 |
| Ellis, S | 1 |
| Mehta, N | 1 |
| Holst, JJ | 2 |
| Geliebter, A | 1 |
| Izawa, T | 1 |
| Travlos, GS | 1 |
| Cortes, RA | 1 |
| Clayton, NP | 1 |
| Sills, RC | 1 |
| Pandiri, AR | 1 |
| Morales-Romero, J | 1 |
| Ortíz-León, MC | 1 |
| Hernández-Gutiérrez, H | 1 |
| Bahena-Cerón, RA | 1 |
| Miranda-Reza, A | 1 |
| Marín-Carmona, JA | 1 |
| Rodríguez-Romero, E | 1 |
| Mora, SI | 1 |
| García-Román, J | 1 |
| Peréz-Carreón, JI | 1 |
| Rivadeneyra-Domínguez, E | 1 |
| Riande-Juárez, G | 1 |
| García-Román, R | 2 |
| Francés, R | 1 |
| Bandoli, G | 1 |
| Palmsten, K | 1 |
| Chambers, C | 1 |
| Baum, RA | 1 |
| Woolum, JA | 1 |
| Bailey, AM | 1 |
| Howell, MM | 1 |
| Weant, KA | 1 |
| Geraghty, L | 1 |
| Mohan, S | 1 |
| Webb, AN | 1 |
| Su, MK | 1 |
| Akpunonu, P | 1 |
| Chomchai, S | 1 |
| Chomchai, C | 1 |
| Toyoda, T | 1 |
| Cho, YM | 1 |
| Akagi, JI | 1 |
| Mizuta, Y | 1 |
| Matsushita, K | 1 |
| Nishikawa, A | 1 |
| Imaida, K | 1 |
| Ogawa, K | 1 |
| Ciftci, B | 1 |
| Ekinci, M | 1 |
| Celik, EC | 1 |
| Kaciroglu, A | 1 |
| Karakaya, MA | 1 |
| Demiraran, Y | 1 |
| Ozdenkaya, Y | 1 |
| Hakim, M | 1 |
| Anderson, BJ | 1 |
| Walia, H | 1 |
| Tumin, D | 1 |
| Michalsky, MP | 1 |
| Syed, A | 1 |
| Tobias, JD | 1 |
| Dore, JP | 1 |
| Butterworth, JF | 1 |
| Pais, R | 1 |
| Rusu, E | 1 |
| Ratziu, V | 1 |
| Wang, C | 1 |
| Wu, M | 1 |
| Arvapalli, R | 1 |
| Dai, X | 1 |
| Mahmood, M | 1 |
| Driscoll, H | 1 |
| Rice, KM | 1 |
| Blough, E | 1 |
| Holt, EW | 1 |
| DeMartini, S | 1 |
| Davern, TJ | 1 |
| Mehta, G | 1 |
| Rothstein, KD | 1 |
| Carr, RD | 1 |
| Larsen, MO | 1 |
| Jelic, K | 1 |
| Lindgren, O | 1 |
| Vikman, J | 1 |
| Deacon, CF | 1 |
| Ahrén, B | 1 |
| Shertzer, HG | 2 |
| Kendig, EL | 2 |
| Nasrallah, HA | 1 |
| Johansson, E | 1 |
| Genter, MB | 2 |
| Wang, HY | 1 |
| Pizzichini, MM | 1 |
| Becker, AB | 1 |
| Duncan, JM | 1 |
| Ferguson, AC | 1 |
| Greene, JM | 1 |
| Rennie, DC | 1 |
| Senthilselvan, A | 1 |
| Taylor, BW | 1 |
| Sears, MR | 1 |
| Xu, J | 1 |
| Kulkarni, SR | 1 |
| Li, L | 1 |
| Slitt, AL | 1 |
| Aubert, J | 1 |
| Begriche, K | 1 |
| Delannoy, M | 1 |
| Morel, I | 1 |
| Pajaud, J | 1 |
| Ribault, C | 1 |
| Lepage, S | 1 |
| McGill, MR | 1 |
| Lucas-Clerc, C | 1 |
| Turlin, B | 1 |
| Robin, MA | 1 |
| Jaeschke, H | 1 |
| Fromenty, B | 1 |
| Schenk, JM | 1 |
| Calip, GS | 1 |
| Tangen, CM | 1 |
| Goodman, P | 1 |
| Parsons, JK | 1 |
| Thompson, IM | 1 |
| Kristal, AR | 1 |
| Neill, AS | 1 |
| Nagle, CM | 1 |
| Protani, MM | 1 |
| Obermair, A | 1 |
| Spurdle, AB | 1 |
| Webb, PM | 1 |
| Najman, DM | 1 |
| Kapoor, P | 1 |
| Serrano, A | 1 |
| Tckachenko, D | 1 |
| Bowen, J | 1 |
| Noakes, M | 1 |
| Trenerry, C | 1 |
| Clifton, PM | 1 |
| Hoybye, C | 1 |
| Barkeling, B | 1 |
| Naslund, E | 1 |
| Thorén, M | 1 |
| Hellstrom, PM | 1 |
| Wong, CA | 1 |
| McCarthy, RJ | 1 |
| Fitzgerald, PC | 1 |
| Raikoff, K | 1 |
| Avram, MJ | 1 |
| Schneider, SN | 1 |
| Clegg, DJ | 1 |
| D'Alessio, DA | 1 |
| Abernethy, DR | 2 |
| Greenblatt, DJ | 2 |
| Divoll, M | 2 |
| Shader, RI | 1 |
| Pounder, DJ | 1 |
| Terry, SI | 1 |
| Gould, JC | 1 |
| McManus, JP | 1 |
| Prescott, LF | 1 |
| Ameer, B | 1 |
| Lee, WH | 1 |
| Kramer, WG | 1 |
| Granville, GE | 1 |
| Tuntaterdtum, S | 2 |
| Chaudhary, IP | 2 |
| Cibull, M | 2 |
| Robertson, LW | 2 |
| Blouin, RA | 3 |
| McNamara, PJ | 2 |
| Schenker, S | 1 |
| Speeg , KV | 1 |
| Perez, A | 1 |
| Finch, J | 1 |
| Raucy, JL | 1 |
| Lasker, JM | 1 |
| Kraner, JC | 1 |
| Salazar, DE | 1 |
| Lieber, CS | 1 |
| Corcoran, GB | 3 |
| Wong, BK | 2 |
| Shum, L | 1 |
| Galinsky, RE | 1 |
| Dickson, P | 1 |
| McClain, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Lidocaine, Dexmedetomidine and Ketamine in Multimodal Analgesia Management Following Sleeve Gastrectomy Surgery: A Randomized Double-Blind Trial[NCT04836819] | 78 participants (Actual) | Interventional | 2021-04-08 | Completed | |||
| Comparison of Intravenous Ibuprofen and Erector Spinae Plane Block for Postoperative Pain Management After Laparoscopic Sleeve Gastrectomy. A Randomized Controlled Study[NCT04232072] | 0 participants (Actual) | Interventional | 2020-02-11 | Withdrawn (stopped due to no participants) | |||
| The Clock Thickens: Morning or Evening Training for the Treatment of NAFLD? (TikTac Study)[NCT05987748] | 40 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Do Preoperative Carbohydrate Drinks Prevent Preoperative Catabolism in Mothers Undergoing Elective Caesarean Section? A Randomised Controlled Study[NCT03220997] | 200 participants (Anticipated) | Interventional | 2017-08-31 | Not yet recruiting | |||
| Acetaminophen Pharmacokinetics in Bariatric Patients[NCT02982928] | 11 participants (Actual) | Observational | 2017-03-06 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To determine whether adequate serum concentration of acetaminophen is achieved. (NCT02982928)
Timeframe: 15-20 minutes; 30-40 minutes; 50-70 minutes; 80-100 minutes; 2 Hours, 4 Hours; 8 Hours; and 12-Hours Post-IV acetaminophen administration
| Intervention | µg.mL-1 (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| 15-20 minutes | 30-40 minutes | 50-70 minutes | 80-100 minutes | 2 hours | 4 hours | 8 hours | 12 hours | |
| Bariatric Surgery | 17 | 14 | 9 | 5 | 0 | 0 | 0 | 0 |
4 reviews available for acetaminophen and Obesity
| Article | Year |
|---|---|
Acetaminophen-Induced Liver Damage in Hepatic Steatosis.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Hepatocytes; Humans; No | 2020 |
The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease.
Topics: Acetaminophen; Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; He | 2014 |
Health maintenance issues in cirrhosis.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Comorbidity; Disease Progression; Health | 2009 |
Aspirin, nonsteroidal anti-inflammatory drugs, paracetamol and risk of endometrial cancer: a case-control study, systematic review and meta-analysis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Australia; Case-Control Studies; Co | 2013 |
5 trials available for acetaminophen and Obesity
| Article | Year |
|---|---|
Comparison of Intravenous Ibuprofen and Paracetamol for Postoperative Pain Management after Laparoscopic Sleeve Gastrectomy. A Randomized Controlled Study.
Topics: Acetaminophen; Administration, Intravenous; Bariatric Surgery; Gastrectomy; Humans; Ibuprofen; Lapar | 2019 |
Comparison of Intravenous Ibuprofen and Paracetamol for Postoperative Pain Management after Laparoscopic Sleeve Gastrectomy. A Randomized Controlled Study.
Topics: Acetaminophen; Administration, Intravenous; Bariatric Surgery; Gastrectomy; Humans; Ibuprofen; Lapar | 2019 |
Comparison of Intravenous Ibuprofen and Paracetamol for Postoperative Pain Management after Laparoscopic Sleeve Gastrectomy. A Randomized Controlled Study.
Topics: Acetaminophen; Administration, Intravenous; Bariatric Surgery; Gastrectomy; Humans; Ibuprofen; Lapar | 2019 |
Comparison of Intravenous Ibuprofen and Paracetamol for Postoperative Pain Management after Laparoscopic Sleeve Gastrectomy. A Randomized Controlled Study.
Topics: Acetaminophen; Administration, Intravenous; Bariatric Surgery; Gastrectomy; Humans; Ibuprofen; Lapar | 2019 |
Acetaminophen pharmacokinetics in severely obese adolescents and young adults.
Topics: Acetaminophen; Administration, Intravenous; Adolescent; Analgesics, Non-Narcotic; Bariatric Surgery; | 2019 |
Indications for and use of nonsteroidal antiinflammatory drugs and the risk of incident, symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Cohort Studies; Co | 2012 |
Energy intake, ghrelin, and cholecystokinin after different carbohydrate and protein preloads in overweight men.
Topics: Acetaminophen; Adult; Amino Acids; Analgesics, Non-Narcotic; Blood Glucose; Caseins; Cholecystokinin | 2006 |
Gastric emptying of water in obese pregnant women at term.
Topics: Acetaminophen; Adult; Anesthesia, Obstetrical; Body Mass Index; Cesarean Section; Cross-Over Studies | 2007 |
30 other studies available for acetaminophen and Obesity
| Article | Year |
|---|---|
Time of day differences in appetite and gut hormone responses to meal and stress challenges in adults with normal-weight and obesity.
Topics: Acetaminophen; Adult; Appetite; Cross-Over Studies; Energy Intake; Gastrointestinal Hormones; Ghreli | 2022 |
Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
[Risk factors for metabolic dysfunction-associated fatty liver disease in the Hispanic-Mexican population.]
Topics: Acetaminophen; Fatty Liver; Hispanic or Latino; Humans; Mexico; Obesity; Risk Factors; Spain | 2023 |
Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Arthritis; Behavioral Symptoms; Cohort Studies; Dose | 2020 |
Evaluation of Dosing Strategies of N-acetylcysteine for Acetaminophen Toxicity in Patients Greater than 100 Kilograms: Should the Dosage Cap Be Used?
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2021 |
Being overweight or obese as a risk factor for acute liver injury secondary to acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Body Mass Index; Chemical and Drug Induced Liver I | 2018 |
A 13-week subchronic toxicity study of acetaminophen using an obese rat model.
Topics: Acetaminophen; Administration, Oral; Animals; Antipyretics; Disease Models, Animal; Dose-Response Re | 2018 |
Acetaminophen dosing in the era of enhanced recovery after surgery.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Humans; Obesity; Pain, Postoperative; Young Adu | 2019 |
Acetaminophen attenuates obesity-related renal injury through ER-mediated stress mechanisms.
Topics: Acetaminophen; Activating Transcription Factor 4; Albuminuria; Analgesics, Non-Narcotic; Animals; Ap | 2014 |
Acute Liver Failure Due to Acetaminophen Poisoning in Patients With Prior Weight Loss Surgery: A Case Series.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bariatric Surgery; Chemical and Drug Induced Liver I | 2015 |
Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men.
Topics: Acetaminophen; Adult; Area Under Curve; Dipeptidyl Peptidase 4; Food; Gastric Inhibitory Polypeptide | 2010 |
Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole.
Topics: Acetaminophen; Adipose Tissue; Adipose Tissue, White; Animals; Antioxidants; Antipsychotic Agents; B | 2010 |
Disparate geographic prevalences of asthma, allergic rhinoconjunctivitis and atopic eczema among adolescents in five Canadian cities.
Topics: Acetaminophen; Adolescent; Asian People; Asthma; Child; Conjunctivitis, Allergic; Dermatitis, Atopic | 2010 |
UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Enzyme Induction; Fasting; Fatty | 2012 |
Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.
Topics: 3-Hydroxybutyric Acid; Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P- | 2012 |
Hypertension and obesity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Blood Pressure; Body Mass Index; | 2003 |
Eating behavior and gastric emptying in adults with Prader-Willi syndrome.
Topics: Acetaminophen; Adolescent; Adult; Body Mass Index; Case-Control Studies; Feeding Behavior; Female; G | 2007 |
Acetaminophen normalizes glucose homeostasis in mouse models for diabetes.
Topics: Acetaminophen; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; D | 2008 |
Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam, and acetaminophen.
Topics: Acetaminophen; Adult; Aged; Anti-Anxiety Agents; Female; Glucuronates; Humans; Lorazepam; Male; Midd | 1983 |
Problems in the necropsy diagnosis of alcoholic liver disease.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; D | 1984 |
Absorption of penicillin and paracetamol after small intestinal bypass surgery.
Topics: Acetaminophen; Adult; Female; Humans; Ileum; Intestinal Absorption; Jejunum; Male; Middle Aged; Obes | 1982 |
Obesity, sex, and acetaminophen disposition.
Topics: Acetaminophen; Adult; Aged; Body Weight; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged | 1982 |
The effect of obesity on acetaminophen pharmacokinetics in man.
Topics: Acetaminophen; Half-Life; Humans; Kinetics; Male; Obesity | 1981 |
Acetaminophen hepatotoxicity: influence of phenobarbital and beta-naphthoflavone treatment in obese and lean Zucker rats.
Topics: Acetaminophen; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme A | 1993 |
Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways.
Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Glutathione; Isoenz | 1993 |
The effects of food restriction in man on hepatic metabolism of acetaminophen.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Diet, Reducing; Female; Humans | 2001 |
Induction of cytochrome P450IIE1 in the obese overfed rat.
Topics: Acetaminophen; Aniline Hydroxylase; Animals; Cytochrome P-450 CYP2E1; Energy Intake; Enzyme Inductio | 1991 |
Obesity as a risk factor in drug-induced organ injury: increased liver and kidney damage by acetaminophen in the obese overfed rat.
Topics: Acetaminophen; Animals; Kidney; Liver; Male; Obesity; Rats; Rats, Inbred Strains; Risk; Time Factors | 1987 |
Acetaminophen sulfation deficit in obese rats overfed an energy-dense cafeteria diet.
Topics: Acetaminophen; Animals; Biotransformation; Kinetics; Male; Obesity; Rats; Rats, Inbred Strains | 1987 |
Phenobarbital induction and acetaminophen hepatotoxicity: resistance in the obese Zucker rodent.
Topics: Acetaminophen; Animals; Enzyme Induction; Glutathione; Liver; Obesity; Phenobarbital; Rats; Rats, Zu | 1987 |