Compounds > acetaminophen
Page last updated: 2024-10-22

acetaminophen and Nausea

acetaminophen has been researched along with Nausea in 83 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12."9.30Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi ( Chou, JC; Daniels, SE; Giannakopoulos, HE; Granquist, EJ; Levin, LM; Maibach, H; Muse, DD; Oreadi, D; Papas, AS; Patrick, K; Schachtel, BP; Zuniga, JR, 2019)
"A fixed-dose combination biphasic immediate-release (IR)/extended-release (ER) hydrocodone bitartrate (HB)/acetaminophen (APAP) tablet is being developed for the management of acute pain severe enough to require opioid treatment and for which alternative treatment options are inadequate."9.20Randomized, double-blind, placebo-controlled study of the efficacy and safety of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen tablets for acute postoperative pain. ( Barrett, T; Chen, Y; Giuliani, MJ; Kostenbader, K; Margulis, R; Singla, N; Young, JL; Zheng, Y, 2015)
" Vomiting, retching, or need for rescue antiemetic treatment at 2 h was reported in 39 of 108 patients assigned to the shorter modified protocol compared with 71 of 109 allocated to the standard acetylcysteine regimen (adjusted odds ratio 0·26, 97·5% CI 0·13-0·52; p<0·0001), and in 45 of 109 patients who received ondansetron compared with 65 of 108 allocated placebo (0·41, 0·20-0·80; p=0·003)."9.19Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. ( Bateman, DN; Butcher, I; Cooper, JG; Coyle, J; Dear, JW; Eddleston, M; Gray, A; Lewis, SC; Rodriguez, A; Sandilands, EA; Thanacoody, HK; Thomas, SH; Veiraiah, A; Vliegenthart, AD; Webb, DJ, 2014)
"Intravenous acetaminophen plus oral oxycodone is as effective as intravenous morphine sulfate in acute pain control in emergency department but with a less desirable safety profile."9.19Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014)
" The objective of this study was to investigate the efficacy and safety of an extended-release, twice-daily fixed combination of 75 mg tramadol/650 mg paracetamol (DDS-06C) in the treatment of moderate-to-severe pain, using acute low back pain as a model."9.16Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain. ( Bouchard, S; Lasko, B; Levitt, RJ; Rainsford, KD; Robertson, S; Rozova, A, 2012)
"Long-term treatment with tramadol LP once daily is generally safe in patients with osteoarthritis or refractory low back pain."9.11Long-term tolerability of tramadol LP, a new once-daily formulation, in patients with osteoarthritis or low back pain. ( Coffiner, M; Fontaine, D; Malonne, H; Peretz, A; Sereno, A; Sonet, B; Vanderbist, F, 2005)
"We performed a prospective, single arm, observational study examining the effectiveness of the 5HT3 receptor antagonist ondansetron in the management if nausea and vomiting associated with acetaminophen poisoning."9.08The use of ondansetron in the treatment of nausea and vomiting associated with acetaminophen poisoning. ( Chen, R; Clark, RF; Harchelroad, F; Johnson, CL; Williams, SR, 1996)
" This study has attempted to assess postoperative analgesic consumption and nausea and vomiting after general anaesthesia for tonsillectomy using either paracetamol premedication, paracetamol plus a NSAID or intravenous morphine to provide postoperative analgesia."9.08Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques. ( Mather, SJ; Peutrell, JM, 1995)
"A prospective, comparative, randomized study to assess rectal acetaminophen (n = 45) to intravenous fentanyl-droperidol (n = 45) to resolve recovery profile, emesis rate, and adequacy of analgesia in a pediatric strabismus repair population was performed, with standardization of the anesthetic technique."9.08Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol. ( Cruz, OA; Krock, JL; Padda, GS, 1997)
"At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy."9.07Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993)
"Doses of 600 mg and 1200 mg of D(-)penicillamine daily were superior to a standard regimen of therapy in rheumatoid arthritis."9.04Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen. ( Davies, J; Dixon, AJ; Dormandy, TL; Hamilton, EB; Holt, PJ; Mason, RM; Thompson, M; Weber, JC; Zutshi, DW, 1975)
"The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement."7.74[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine]. ( Abe, F; Furuya, A; Nagamine, N; Nonaka, A; Suzuki, S, 2007)
"To describe the efficacy of ondansetron for the treatment of poisoning-associated vomiting in two patients following drug intoxication."7.69Ondansetron for treating nausea and vomiting in the poisoned patient. ( Marx, CM; Reed, MD, 1994)
" There was no difference in the mean frequency or dosage of rescue medication required by both groups, and the majority of patients in both the TA-ER and TA-IR groups rated their pain improvement as 'much' or 'somewhat better'."6.80A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement. ( Bin, SI; Chang, N; Cho, SD; Choi, CH; Ha, CW; Kang, SB; Kyung, HS; Lee, JH; Lee, MC; Park, YB; Rhim, HY; Seo, SS, 2015)
"The acetaminophen group had lower pain scores on Day 1 (2."6.69Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain. ( Fox, L; McGuinnety, M; Schug, SA; Sidebotham, DA; Thomas, J, 1998)
"To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12."5.30Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi ( Chou, JC; Daniels, SE; Giannakopoulos, HE; Granquist, EJ; Levin, LM; Maibach, H; Muse, DD; Oreadi, D; Papas, AS; Patrick, K; Schachtel, BP; Zuniga, JR, 2019)
"A fixed-dose combination biphasic immediate-release (IR)/extended-release (ER) hydrocodone bitartrate (HB)/acetaminophen (APAP) tablet is being developed for the management of acute pain severe enough to require opioid treatment and for which alternative treatment options are inadequate."5.20Randomized, double-blind, placebo-controlled study of the efficacy and safety of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen tablets for acute postoperative pain. ( Barrett, T; Chen, Y; Giuliani, MJ; Kostenbader, K; Margulis, R; Singla, N; Young, JL; Zheng, Y, 2015)
" Vomiting, retching, or need for rescue antiemetic treatment at 2 h was reported in 39 of 108 patients assigned to the shorter modified protocol compared with 71 of 109 allocated to the standard acetylcysteine regimen (adjusted odds ratio 0·26, 97·5% CI 0·13-0·52; p<0·0001), and in 45 of 109 patients who received ondansetron compared with 65 of 108 allocated placebo (0·41, 0·20-0·80; p=0·003)."5.19Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. ( Bateman, DN; Butcher, I; Cooper, JG; Coyle, J; Dear, JW; Eddleston, M; Gray, A; Lewis, SC; Rodriguez, A; Sandilands, EA; Thanacoody, HK; Thomas, SH; Veiraiah, A; Vliegenthart, AD; Webb, DJ, 2014)
"Intravenous acetaminophen plus oral oxycodone is as effective as intravenous morphine sulfate in acute pain control in emergency department but with a less desirable safety profile."5.19Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014)
" The objective of this study was to investigate the efficacy and safety of an extended-release, twice-daily fixed combination of 75 mg tramadol/650 mg paracetamol (DDS-06C) in the treatment of moderate-to-severe pain, using acute low back pain as a model."5.16Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain. ( Bouchard, S; Lasko, B; Levitt, RJ; Rainsford, KD; Robertson, S; Rozova, A, 2012)
"A randomized, placebo-controlled, double-blind study to evaluate the effect of intravenously (IV) administered acetaminophen on postoperative pain in children and adolescents undergoing surgery for idiopathic scoliosis or spondylolisthesis."5.16Acetaminophen improves analgesia but does not reduce opioid requirement after major spine surgery in children and adolescents. ( Hartikainen, T; Helenius, I; Hiller, A; Kaukonen, M; Korpela, R; Meretoja, OA; Neuvonen, PJ; Nurmi, E; Taivainen, T, 2012)
"Our aim was to show the efficacy of naproxen and paracetamol with and without pethidine on pain and nausea and vomiting after adenoidectomy."5.12Oral naproxen but not oral paracetamol reduces the need for rescue analgesic after adenoidectomy in children. ( Korpela, R; Laakso, E; Meretoja, OA; Silvola, J, 2007)
"Long-term treatment with tramadol LP once daily is generally safe in patients with osteoarthritis or refractory low back pain."5.11Long-term tolerability of tramadol LP, a new once-daily formulation, in patients with osteoarthritis or low back pain. ( Coffiner, M; Fontaine, D; Malonne, H; Peretz, A; Sereno, A; Sonet, B; Vanderbist, F, 2005)
"There was no statistical difference in the mean reduction in pain score between any of the combinations at any point, although combination therapy was the first to reach a clinically significant reduction in pain score (<13 mm), and diclofenac-paracetamol combinations consistently produced a greater reduction in mean pain score than either nonsteroidal antiinflammatory drugs or paracetamol alone."5.11Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury. ( Lam, PK; Man, SY; Rainer, TH; Woo, WW, 2005)
" The aim of this study was to compare the effectiveness and tolerability of a fixed combination of domperidone and paracetamol (Domperamol; Servier), which has anti-nauseant and anti-emetic activity, with sumatriptan 50 mg in moderate to severe migraine."5.09Comparison of a fixed combination of domperidone and paracetamol (Domperamol) with sumatriptan 50 mg in moderate to severe migraine: a randomised UK primary care study. ( Ball, K; Dowson, A; Haworth, D, 2000)
" This study has attempted to assess postoperative analgesic consumption and nausea and vomiting after general anaesthesia for tonsillectomy using either paracetamol premedication, paracetamol plus a NSAID or intravenous morphine to provide postoperative analgesia."5.08Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques. ( Mather, SJ; Peutrell, JM, 1995)
"Infusion-related adverse events (IRAEs) such as nausea, vomiting, fever, chills, and thrombophlebitis that are associated with amphotericin B therapy often lead clinicians to prescribe a number of adjunctive pretreatment medications in an attempt to reduce the incidence and severity of these events."5.08Pretreatment regimens for adverse events related to infusion of amphotericin B. ( Cleary, JD; Goodwin, SD; Grasela, TH; Taylor, JW; Walawander, CA, 1995)
"We performed a prospective, single arm, observational study examining the effectiveness of the 5HT3 receptor antagonist ondansetron in the management if nausea and vomiting associated with acetaminophen poisoning."5.08The use of ondansetron in the treatment of nausea and vomiting associated with acetaminophen poisoning. ( Chen, R; Clark, RF; Harchelroad, F; Johnson, CL; Williams, SR, 1996)
"A prospective, comparative, randomized study to assess rectal acetaminophen (n = 45) to intravenous fentanyl-droperidol (n = 45) to resolve recovery profile, emesis rate, and adequacy of analgesia in a pediatric strabismus repair population was performed, with standardization of the anesthetic technique."5.08Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol. ( Cruz, OA; Krock, JL; Padda, GS, 1997)
"At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy."5.07Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993)
"The full dose of acetaminophen significantly reduced the incidence of sore arm and nausea without affecting the antibody response."5.07Effects of acetaminophen on adverse effects of influenza vaccination in health care workers. ( Aoki, FY; Cheang, M; Hammond, GW; Murdzak, C; Seklà, LH; Wright, B; Yassi, A, 1993)
" Acetaminophen and meperidine were given for postoperative pain."5.07Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy. ( Furst, SR; Rodarte, A, 1994)
"Doses of 600 mg and 1200 mg of D(-)penicillamine daily were superior to a standard regimen of therapy in rheumatoid arthritis."5.04Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen. ( Davies, J; Dixon, AJ; Dormandy, TL; Hamilton, EB; Holt, PJ; Mason, RM; Thompson, M; Weber, JC; Zutshi, DW, 1975)
"The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement."3.74[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine]. ( Abe, F; Furuya, A; Nagamine, N; Nonaka, A; Suzuki, S, 2007)
" Switching to an opioid combined with acetaminophen or aspirin does not result in greater analgesia, but increases the incidence of side effects such as drowsiness and nausea."3.70Additive analgesia without opioid side effects. ( Dionne, R, 2000)
"To describe the efficacy of ondansetron for the treatment of poisoning-associated vomiting in two patients following drug intoxication."3.69Ondansetron for treating nausea and vomiting in the poisoned patient. ( Marx, CM; Reed, MD, 1994)
"Postoperative pain was significantly less in the bupivacaine group at 240 and 360 min after the surgery."3.11Comparing the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children. ( Ayatollahi, V; Hosseini, H; Meybodian, M; Shariatmadari, M; Vaziribozorg, S, 2022)
" In both studies, a high-fat meal did not affect the Cmax for hydrocodone."2.80Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials. ( Devarakonda, K; Giuliani, MJ; Kostenbader, K; Young, JL, 2015)
" There was no difference in the mean frequency or dosage of rescue medication required by both groups, and the majority of patients in both the TA-ER and TA-IR groups rated their pain improvement as 'much' or 'somewhat better'."2.80A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement. ( Bin, SI; Chang, N; Cho, SD; Choi, CH; Ha, CW; Kang, SB; Kyung, HS; Lee, JH; Lee, MC; Park, YB; Rhim, HY; Seo, SS, 2015)
"Active disease was defined by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) for more than 3 at randomization."2.78Tramadol/acetaminophen combination as add-on therapy in the treatment of patients with ankylosing spondylitis. ( Chang, IC; Chang, JK; Lee, MY; Tsou, HK; Wei, JC; Yeo, K; Yu, CT, 2013)
" With the exception of constipation, scheduled analgesic dosing did not increase the frequency or severity of opioid-related adverse effects."2.75A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy. ( Holdridge-Zeuner, D; Lanier, B; Mahoney, K; Miaskowski, C; Paul, SM; Savedra, MC; Sutters, KA; Waite, S, 2010)
"Isradipine dose was 30 mg sustained release nightly plus 15 mg immediate release 2 hr before cocaine infusion."2.71Effects of repeated-dose isradipine on the abuse liability of cocaine. ( Ait-Daoud, N; Johnson, BA; Mauldin, JB; Murff, WL; Roache, JD; Thornton, JE; Wells, LT, 2005)
"Most people who experience migraine use OTC medications to treat their symptoms, but no head-to-head clinical trials comparing these agents with prescription migraine therapies have been published."2.71Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial. ( Baggish, J; Battikha, JP; Elkind, AH; Gallagher, RM; Goldstein, J; Hoffman, H; Saper, JR; Silberstein, SD; Smith, TR, 2005)
"Tramadol/APAP was superior to tramadol (P < 0."2.71A double-blind placebo-controlled comparison of tramadol/acetaminophen and tramadol in patients with postoperative dental pain. ( Fisher, A; Fricke, JR; Hewitt, DJ; Jordan, DM; Rosenthal, NR, 2004)
"When remifentanil was given, there were no significant differences between the two postures in maximal acetaminophen concentration (right side, 34 micromol."2.71The delay of gastric emptying induced by remifentanil is not influenced by posture. ( Thörn, SE; Walldén, J; Wattwil, M, 2004)
"Acetaminophen may have been blunted some adverse effects."2.70Adverse effects of superactivated charcoal administered to healthy volunteers. ( Sato, RL; Sumida, SM; Wong, JJ; Yamamoto, LG, 2002)
"The acetaminophen group had lower pain scores on Day 1 (2."2.69Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain. ( Fox, L; McGuinnety, M; Schug, SA; Sidebotham, DA; Thomas, J, 1998)
"When postoperative pain occurred, loading doses of either 10 mg tramadol or 1 mg morphine intravenous increments were administered in a double-blind fashion until the pain control was judged to be satisfactory by the patient."2.69Comparison of intravenous patient-controlled analgesia with tramadol versus morphine after microvascular breast reconstruction. ( Pitkänen, M; Rosenberg, PH; Silvasti, M; Svartling, N, 2000)
" This dosage of paracetamol is lower than the current recommended dosage, which is 40 mg kg(-1) loading dose followed by 20 mg kg(-1) 8 h(-1)."2.69Double-blind randomized study of tramadol vs. paracetamol in analgesia after day-case tonsillectomy in children. ( Dort, JP; Pendeville, PE; Veyckemans, F; Von Montigny, S, 2000)
" This corresponds to decreases in bioavailability of 67, 11, and 21%."2.68Efficacy of ipecac during the first hour after drug ingestion in human volunteers. ( Saincher, A; Sitar, DS; Tenenbein, M, 1997)
"Postoperative pain was reported in 35% of patients, with no significant difference between treated and control patients."2.67Prophylactic paracetamol for analgesia after vaginal termination of pregnancy. ( Ashley, J; Cade, L, 1993)
" Tolerance in terms of withdrawals or side-effect profile did not appear to the dosage of each preparation administered."2.67The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextropropoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips. ( Costello, F; Eves, MJ; James, IG; Lloyd, RS; Miller, AJ, 1992)
"Data on assessment and treatment of spinal cord compression are reviewed."2.40Management of pain and spinal cord compression in patients with advanced cancer. ACP-ASIM End-of-life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine. ( Abrahm, JL, 1999)
" The possible causes for the injury from ostensibly nontoxic drug levels appear to be either the induction by chronic alcohol intake of the cytochrome P-450 system responsible for converting acetaminophen to a toxic metabolite, or the effect of alcoholism and the associated malnutrition in reducing the glutathione concentration, responsible normally for preventing hepatotoxicity by conjugation with the toxic metabolite."2.37Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. ( Adler, E; Benjamin, SB; Cuccherini, BA; Seeff, LB; Zimmerman, HJ, 1986)
"Flushing was the most common type of AE followed by nausea and hypertension."1.40Infusion technique of hematopoietic progenitor cells and related adverse events (CME). ( Bryant, SC; Gastineau, DA; Greiner, CW; Hogan, WJ; Jacob, EK; Lingineni, RK; Mohr, A; Mulay, SB; Padley, D, 2014)
"Trauma triggered migraine is seen more frequently in children, adolescents and young adults."1.40[Footballer's migraine instead of concussion]. ( Borggreve, AG; Haan, J; Lansink, JG; van Oosterhout, WP, 2014)
"Simvastatin is a substrate of CYP3A4 enzyme."1.38Paracetamol and simvastatin: a potential interaction resulting in hepatotoxicity. ( Gumbrevičius, G; Stankevičius, E; Sveikata, A; Sveikatienė, R, 2012)
"Acetaminophen poisoning is a common clinical problem, and early identification of patients with more severe poisoning is key to improving outcomes."1.36Association between gastrointestinal manifestations following acetaminophen poisoning and outcome in 291 acetaminophen poisoning patients. ( Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH, 2010)
" The primary safety outcome was the percentage of patients with NAC-related adverse events."1.36A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose. ( Aguilera, E; Al-Helial, M; Arnold, T; Bebarta, VS; Bogdan, G; Buchanan, J; Clark, RF; Dart, R; Delgado, J; Froberg, B; Haur, W; Heard, K; Hoppe, J; Kao, L; Kokko, J; Lares, C; Lavonas, E; McDonagh, J; Mendoza, C; Mlynarchek, S; O'Malley, G; Odujebe, O; Qi, M; Rhyee, S; Stanford, C; Tan, HH; Tran, NN; Varney, S; Zosel, A, 2010)
"The morphine was administered as a single bolus, following delivery, in doses ranging from 2 to 5 mg."1.28Epidural morphine for analgesia after caesarean section: a report of 4880 patients. ( Douglas, MJ; Fuller, JG; McMorland, GH; Palmer, L, 1990)
" The non-steroid antirheumatic benoxaprofen was used alone in a dosage of a 1 x 600 mg tablet daily."1.26[Benoxaprofen in the treatment of spondylosis and spondylarthrosis (author's transl)]. ( Hevelke, G; Schilling, E, 1981)
"One hundred and fifty patients with migraine attacks attending the Copenhagen acute migraine clinic were treated either with metoclopramide 10 mg i."1.26A double blind study of metoclopramide in the treatment of migraine attacks. ( Aebelholt-Krabbe, A; Melgaard, B; Olesen, J; Tfelt-Hansen, P; Veilis, B, 1980)

Research

Studies (83)

TimeframeStudies, this research(%)All Research%
pre-199015 (18.07)18.7374
1990's21 (25.30)18.2507
2000's19 (22.89)29.6817
2010's25 (30.12)24.3611
2020's3 (3.61)2.80

Authors

AuthorsStudies
Hosseini, H1
Shariatmadari, M1
Ayatollahi, V1
Vaziribozorg, S1
Meybodian, M1
Anter, ME1
Abdel Attey Saleh, S1
Shawkey Allam, S1
Mohamed Nofal, A1
Vogelbacher, LC1
Thimme, R1
Subedi, Y1
Zuniga, JR1
Papas, AS1
Daniels, SE1
Patrick, K1
Muse, DD1
Oreadi, D1
Giannakopoulos, HE1
Granquist, EJ1
Levin, LM1
Chou, JC1
Maibach, H1
Schachtel, BP1
Walley, AY1
Wakeman, SE1
Eng, G1
Hansen, MS1
Brennum, J1
Moltke, FB1
Dahl, JB1
Ihedioha, U1
Vaughan, S1
Mastermann, J1
Singh, B1
Chaudhri, S1
Bateman, DN1
Dear, JW1
Thanacoody, HK1
Thomas, SH1
Eddleston, M1
Sandilands, EA1
Coyle, J1
Cooper, JG1
Rodriguez, A1
Butcher, I1
Lewis, SC1
Vliegenthart, AD1
Veiraiah, A1
Webb, DJ1
Gray, A1
Zare, MA1
Ghalyaie, AH1
Fathi, M1
Farsi, D1
Abbasi, S1
Hafezimoghadam, P1
Mulay, SB1
Greiner, CW1
Mohr, A1
Bryant, SC1
Lingineni, RK1
Padley, D1
Hogan, WJ1
Gastineau, DA1
Jacob, EK1
O'Connor-Semmes, RL1
Lin, J1
Hodge, RJ1
Andrews, S1
Chism, J1
Choudhury, A1
Nunez, DJ1
Park, YB1
Ha, CW1
Cho, SD1
Lee, MC1
Lee, JH1
Seo, SS1
Kang, SB1
Kyung, HS1
Choi, CH1
Chang, N1
Rhim, HY1
Bin, SI1
Lansink, JG1
van Oosterhout, WP1
Borggreve, AG1
Haan, J1
Singla, N1
Margulis, R1
Kostenbader, K2
Zheng, Y1
Barrett, T1
Giuliani, MJ2
Chen, Y1
Young, JL2
Devarakonda, K1
Simpson, RW1
Wlodarczyk, JH1
Sutters, KA1
Miaskowski, C1
Holdridge-Zeuner, D1
Waite, S1
Paul, SM1
Savedra, MC1
Lanier, B1
Mahoney, K1
Zyoud, SH1
Awang, R1
Sulaiman, SA1
Al-Jabi, SW1
Bebarta, VS1
Kao, L1
Froberg, B1
Clark, RF2
Lavonas, E1
Qi, M1
Delgado, J1
McDonagh, J1
Arnold, T1
Odujebe, O1
O'Malley, G1
Lares, C1
Aguilera, E1
Dart, R1
Heard, K1
Stanford, C1
Kokko, J1
Bogdan, G1
Mendoza, C1
Mlynarchek, S1
Rhyee, S1
Hoppe, J1
Haur, W1
Tan, HH1
Tran, NN1
Varney, S1
Zosel, A1
Buchanan, J1
Al-Helial, M1
Shrikanth, V1
Vanderheiden, A1
Simha, V1
Wark, JD1
Bensen, W1
Recknor, C1
Ryabitseva, O1
Chiodo, J1
Mesenbrink, P1
de Villiers, TJ1
Merivirta, R1
Kuusniemi, KS1
Aantaa, R1
Hurme, SA1
Aärimaa, V1
Leino, KA1
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Kaukonen, M1
Hartikainen, T1
Korpela, R2
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Meretoja, OA2
Gumbrevičius, G1
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Chang, JK1
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DOUJAK, PH1
WIESINGER, G1
Fricke, JR1
Hewitt, DJ1
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Peretz, A1
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Goldstein, J2
Silberstein, SD1
Saper, JR1
Elkind, AH1
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Gallagher, RM1
Battikha, JP2
Hoffman, H1
Baggish, J1
Woo, WW1
Man, SY1
Lam, PK1
Rainer, TH2
Roache, JD1
Johnson, BA1
Ait-Daoud, N1
Mauldin, JB1
Thornton, JE1
Wells, LT1
Murff, WL1
Ternullo, S1
Pavy, E1
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Dureuil, B1
Man, CY1
Cheung, IT1
Cameron, PA1
Silvola, J1
Laakso, E1
Nonaka, A1
Suzuki, S1
Nagamine, N1
Furuya, A1
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Kefford, RH1
Tokola, RA1
Hevelke, G1
Schilling, E1
Tfelt-Hansen, P1
Olesen, J1
Aebelholt-Krabbe, A1
Melgaard, B1
Veilis, B1
Mather, SJ1
Peutrell, JM1
Hall, MD1
Brodsky, L1
Goodwin, SD1
Cleary, JD1
Walawander, CA1
Taylor, JW1
Grasela, TH1
Furst, SR1
Rodarte, A1
Reed, MD1
Marx, CM1
Aoki, FY1
Yassi, A1
Cheang, M1
Murdzak, C1
Hammond, GW1
Seklà, LH1
Wright, B1
Chan, TY1
Chan, AY1
Critchley, JA1
Cade, L2
Ashley, J1
Hovorka, J1
Kallela, H1
Korttila, K1
Chen, R1
Williams, SR1
Johnson, CL1
Harchelroad, F1
Anderson, B1
Kanagasundarum, S1
Woollard, G1
Padda, GS1
Cruz, OA1
Krock, JL1
Gabriel, CM1
Minor, JR1
Vogel, S1
Piscitelli, SC1
Saincher, A1
Sitar, DS1
Tenenbein, M1
Schug, SA1
Sidebotham, DA1
McGuinnety, M1
Thomas, J1
Fox, L1
Abrahm, JL1
Hoffman, HD1
Armellino, JJ1
Hamelsky, SW1
Couch, J1
Blumenthal, H1
Lipton, RB1
Silvasti, M1
Svartling, N1
Pitkänen, M1
Rosenberg, PH1
Pendeville, PE1
Von Montigny, S1
Dort, JP1
Veyckemans, F1
Dowson, A1
Ball, K1
Haworth, D1
Dionne, R1
Edwards, CM1
Stanley, SA1
Davis, R1
Brynes, AE1
Frost, GS1
Seal, LJ1
Ghatei, MA1
Bloom, SR1
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Gómez-Martino, JR1
Novillo, R1
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Davies, J1
Dormandy, TL1
Hamilton, EB1
Holt, PJ1
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Zutshi, DW1
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Scott, JT1
Tiller, J1
Treasure, J1
Lloyd, RS1
Costello, F1
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Ross, AW1
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McMorland, GH1
Douglas, MJ1
Palmer, L1
Howden, CW1
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Hirai, Y1
Yagi, H1
Katase, K1
Shimizu, Y1
Nakayama, K1
Teshima, H1
Hamada, T1
Fujimoto, I1
Yamuchi, K1
Seeff, LB1
Cuccherini, BA1
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Goulding, R1
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Wilkinson, M1

Clinical Trials (16)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Intravenous Paracetamol in Manament of Labour Pain in a Low Resource Setting[NCT04744727]96 participants (Actual)Interventional2019-03-01Completed
Comparison of the Analgesic Effects of Scalp Nerve Block and Intravenous Ibuprofen Applications Under the Guidance of Nociception Level Index (NoL) in Patients Undergoing Elective Supratentorial Craniotomy[NCT05763836]Phase 4102 participants (Anticipated)Interventional2022-11-01Recruiting
A Randomised Trial to Assess the Effectiveness of Pre-treatment With Ondansetron at Reducing Nausea and Vomiting in Patients Treated With Either the Conventional Regimen or a Modified Regimen of Acetylcysteine for Paracetamol Poisoning[NCT01050270]Phase 4222 participants (Actual)Interventional2010-09-30Completed
A Randomized, Active-Controlled, Parallel Group, Double-Blind Study to Compare the Efficacy and Safety of Tramadol HCl/Acetaminophen ER and IR in Subjects Who Complain of Moderate to Severe Postoperative Pain[NCT01814878]Phase 3320 participants (Actual)Interventional2009-11-30Completed
An Open-Label, Randomized, Single-Dose, Three-Period Crossover Study to Evaluate the Pharmacokinetics, Bioavailability, and Safety of COV155 Administered in Normal, Healthy Subjects Under Fed (High- and Low-Fat Meal) and Fasted Conditions[NCT02561650]Phase 148 participants (Actual)Interventional2011-12-31Completed
An Open-Label, Randomized, Single-Dose, Three-Period Crossover Study to Evaluate the Pharmacokinetics, Bioavailability, and Safety of 3 Tablets of COV155 Administered in Normal, Healthy Subjects Under Fed (High- and Low-Fat Meal) and Fasted Conditions[NCT02561741]Phase 130 participants (Actual)Interventional2012-12-31Completed
Home Care Management of Pediatric Pain[NCT00251628]Phase 4211 participants (Actual)Interventional2000-06-30Completed
Randomized Control Trial of Ultrasound-Guided Erector Spinae Block Versus Shoulder Periarticular Anesthetic Infiltration for Pain Control After Arthroscopic Shoulder Surgery[NCT03691922]62 participants (Actual)Interventional2019-07-06Completed
[NCT00643383]Phase 3277 participants (Actual)Interventional2008-03-31Completed
Ultrasound-guided Transversus Abdominis Plane Block After Abdominal Hysterectomy: a Prospective Randomized Controlled Trial[NCT01153503]75 participants (Actual)Interventional2010-04-30Completed
Bilateral Transversus Abdominis Plane Block With or Without Magnesium for Total Abdominal Hysterectomy With or Without Salpingo-oophorectomy: a Randomized Controlled Trial[NCT02680626]Phase 486 participants (Actual)Interventional2016-01-31Terminated (stopped due to Pfannenstiel hysterectomies are now rarely performed so cannot recruit eligible patients)
A Comparison of the Efficacy and Safety of ULTRACET® (Tramadol HCl/Acetaminophen) Versus ULTRAM® (Tramadol HCl) Versus Placebo in Subjects With Pain Following Oral Surgery[NCT00236483]Phase 4456 participants (Actual)Interventional2002-11-30Completed
A Pilot Trial to Determine the Effective Dose of N-acetylcysteine for Opioid Reduction in Patients Undergoing Spine Surgery.[NCT04562597]Phase 1/Phase 250 participants (Actual)Interventional2021-01-20Completed
A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy[NCT01267136]Phase 484 participants (Actual)Interventional2011-01-31Completed
Ropivacaine Through Continuous Infusion Versus Epidural Morphine for Postoperative Analgesia After Emergency Cesarean Section[NCT02410317]Phase 3101 participants (Actual)Interventional2015-02-28Completed
Randomized, Controlled, Double Blind, to Evaluate the Postpartum Analgesia With Epidural Morphine: Analgesic Effect of Two Different Doses Compared to Placebo[NCT04887649]Phase 3114 participants (Actual)Interventional2009-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Dosage of Rescue Medication Administered Because of Insufficient Pain Relief

The dosage of the rescue medication (rescue medications are medicines that are administered to the participants when the efficacy of the study drug is not satisfactory, or the effect of the study drug is too great and is likely to cause a hazard to the participant, or to manage an emergency situation) because of insufficient pain relief was measured after administration of the study drug. Rescue medications allowed were oral or injection of tramadol HCl (intramuscular or intravenous injection). (NCT01814878)
Timeframe: Baseline up to Day 3

InterventionMilligram (Mean)
Tramadol Hydrochloride (HCl)/Acetaminophen ER50.0
Tramadol HCl/Acetaminophen IR51.7

Number of Doses of Rescue Medication Administered Because of Insufficient Pain Relief

The frequency of the rescue medication (rescue medications are medicines that are administered to the participants when the efficacy of the study drug is not satisfactory, or the effect of the study drug is too great and is likely to cause a hazard to the participant, or to manage an emergency situation) because of insufficient pain relief was measured after administration of the study drug. Rescue medications allowed were oral or injection of tramadol HCl (intramuscular or intravenous injection). (NCT01814878)
Timeframe: Baseline up to Day 3

InterventionDoses (Mean)
Tramadol Hydrochloride (HCl)/Acetaminophen ER2.1
Tramadol HCl/Acetaminophen IR1.4

Patient Global Impression of Change (PGIC) Score

The PGIC was used to assess the degree of participant's overall improvement with treatment, and participants were instructed to assess how much the overall status had been improved after investigational product administration compared to baseline in 7 grades (1=Very much improved and B=Very much worsened). (NCT01814878)
Timeframe: Day 3

InterventionUnits on scale (Mean)
Tramadol Hydrochloride (HCl)/Acetaminophen ER2.71
Tramadol HCl/Acetaminophen IR2.60

Sum of Pain Intensity Difference (SPID) at Hour 48

The SPID is time-weighted sum of all observations of pain intensity difference (PID) collected at each measurement time point from Baseline to 48 hours. PID: Baseline pain intensity (PI) minus current PI; PI was assessed using 11-point numeric rating scale (NRS, 0=no pain to 10=worst pain imaginable). PI score ranges from 0-3 where 0=no pain and 3=severe pain. PI score of 0=NRS score of 0, PI score of 1=NRS score >=1 and <=3, PI score of 2=NRS score of >=4 and <=6 and PI score of 3=NRS score of >=7 and <=10. Total score for SPID at 48 hours (SPID48) ranges from -144 (worst) to 144 (best). (NCT01814878)
Timeframe: Hour 48

InterventionUnits on scale (Mean)
Tramadol Hydrochloride (HCl)/Acetaminophen ER32.5
Tramadol HCl/Acetaminophen IR37.2

Time to the First Rescue Medication Administered Because of Insufficient Pain Relief

The time until administration of the first rescue medication (rescue medications are medicines that are administered to the participants when the efficacy of the study drug is not satisfactory, or the effect of the study drug is too great and is likely to cause a hazard to the participant, or to manage an emergency situation) because of insufficient pain relief after administration of the study drug was recorded. Rescue medications allowed were oral or injection of tramadol HCl (intramuscular [directly into muscle] or intravenous injection [directly into vein]). (NCT01814878)
Timeframe: Baseline up to Day 3

InterventionMinutes (Mean)
Tramadol Hydrochloride (HCl)/Acetaminophen ER1339
Tramadol HCl/Acetaminophen IR1212

Sum of Pain Intensity Difference (SPID) at Hour 6, 12 and 24

The SPID is time-weighted sum of all observations of PID collected at each measurement time point from Baseline to 24 hours. PID: Baseline PI minus current PI; PI was assessed using 11-point NRS, 0=no pain to 10=worst pain imaginable. PI score ranges from 0-3 where 0=no pain and 3=severe pain. PI score of 0=NRS score of 0, PI score of 1=NRS score >=1 and <=3, PI score of 2=NRS score of >=4 and <=6 and PI score of 3=NRS score of >=7 and <=10. Total score ranges from -18 (worst) to 18 (best) for SPID6, -36 (worst) to 36 (best) for SPID12 and -72 (worst) to 72 (best) for SPID24. (NCT01814878)
Timeframe: Hour 6, 12, 24

,
InterventionUnits on scale (Mean)
Hour 6Hour 12Hour 24
Tramadol HCl/Acetaminophen IR3.98.117.6
Tramadol Hydrochloride (HCl)/Acetaminophen ER3.67.014.6

Sum of Total Pain Relief and Sum of Pain Intensity Difference (SPRID)

The SPRID is sum of SPID and TOTPAR. In SPID, PI score ranges from 0-3 where 0=no pain and 3=severe pain. PI score of 0=NRS score of 0, PI score of 1=NRS score >=1 and <= 3, PI score of 2=NRS score of >=4 and <=6 and PI score of 3=NRS score of >=7 and <=10. In TOTPAR, pain relief score ranges from 0-4 (0=no change, 1=slight relief, 2=moderate relief, 3=fair relief, 4=pain resolved completely). Total score ranges from -18 (worst) to 42 (best) for SPRID6, -36 (worst) to 84 (best) for SPRID12, -72 (worst) to 168 (best) for SPRID24 and -144 (worst) to 336 (best) for SPRID48. (NCT01814878)
Timeframe: Hour 6, 12, 24, 48

,
InterventionUnits on scale (Mean)
Hour 6Hour 12Hour 24Hour 48
Tramadol HCl/Acetaminophen IR10.923.149.197.0
Tramadol Hydrochloride (HCl)/Acetaminophen ER9.619.641.885.9

Total Pain Relief (TOTPAR) Score

Pain relief was measured on a 5-point categorical scale of 0-4 (0=no change, 1=slight relief, 2=moderate relief, 3=fair relief, 4=pain resolved completely). TOTPAR was calculated as the time-weighted sum over all pain relief up to 48 hours. Total score ranges from 0 (worst) to 24 (best) for TOTPAR6, 0 (worst) to 48 (best) for TOTPAR12, 0 (worst) to 96 (best) for TOTPAR24 and 0 (worst) to 192 (best) for TOTPAR48. (NCT01814878)
Timeframe: Hour 6, 12, 24, 48

,
InterventionUnits on scale (Mean)
Hour 6Hour 12Hour 24Hour 48
Tramadol HCl/Acetaminophen IR6.814.731.061.7
Tramadol Hydrochloride (HCl)/Acetaminophen ER6.012.527.155.6

Morphine Consumption

Morphine consumption over the first 24 hours (NCT01153503)
Timeframe: 24 hours post surgery

Interventionmg (Mean)
Ketorolac 30 mg, IV + TAP Block38.4
TAP Block38.6
Ketorolac 30 mg42.6

Opioid Consumption 12 Hours Post Operative

Post operative opioid consumption in the 12 hours that occur post-operatively. (NCT04562597)
Timeframe: 12 hours

InterventionIV morphine mg equivalents (Mean)
Placebo19.4
N-acetylcysteine (NAC)15.6

Opioid Consumption Every 6 Hours Post Operative

Post operative opioid consumption ry 6 hours post operative. Data are reported as mean (95% CI) or mean difference (95% CI) estimated from a linear mixed model of opioid consumption over time including main effects for treatment group, postoperative time, and the interaction between treatment group and postoperative time and a random subject effect. (NCT04562597)
Timeframe: 6-48 hours

,
InterventionIV morphine mg equivalents (Mean)
6 hours18 hours24 hours30 hours36 hours4248
N-acetylcysteine (NAC)12.019.924.727.229.733.134.9
Placebo14.625.029.634.037.940.943.3

Efficacy of Two Different Liquid Pain Medications: Tramadol vs. Codeine/Acetaminophen During the Post-tonsillectomy Recovery Period.

Average number of post-operative days with pain score >4/10. Pain score assessments were administered once daily by parents using either the Numeric Rating Scale (NRS-11) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 8-15 (von Baeyer et al., 2009) or the Faces Pain Scale-Revised (FPS-R) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 4-10 (Hicks et al., 2001). (NCT01267136)
Timeframe: Efficacy was assessed daily during the 10-day postoperative recovery period.

Interventiondays (Median)
Capital® With Codeine Suspension1.5
Tramadol Suspension1

Number of Participants Reporting Side Effects During the Post-tonsillectomy Recovery Period.

Parent-reported side effects entered in 10-day diary. (NCT01267136)
Timeframe: Side effects will be observed and recorded daily by caregivers for a total of 10 days in the take-home diary.

,
Interventionparticipants (Number)
NauseaVomitingFeverItchingRashSweatingDizzinessHeadacheConstipationOversedationTonsil bleed
Capital® With Codeine Suspension202111519151221143
Tramadol Suspension201810121717172180

Reviews

2 reviews available for acetaminophen and Nausea

ArticleYear
Management of pain and spinal cord compression in patients with advanced cancer. ACP-ASIM End-of-life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine.
    Annals of internal medicine, 1999, Jul-06, Volume: 131, Issue:1

    Topics: Acetaminophen; Drug Administration Schedule; Humans; Narcotics; Nausea; Neoplasms; Pain; Pain Manage

1999
Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure.
    Annals of internal medicine, 1986, Volume: 104, Issue:3

    Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Blood Coagulati

1986

Trials

51 trials available for acetaminophen and Nausea

ArticleYear
Comparing the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022, Volume: 279, Issue:5

    Topics: Acetaminophen; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Double-Blind Method; Female

2022
Efficacy and safety of intravenous paracetamol in management of labour pains in a low resource setting: a randomized clinical trial.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:25

    Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics; Analgesics, Opioid; Dizziness; Double-Blind Metho

2022
Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi
    Pain medicine (Malden, Mass.), 2019, 12-01, Volume: 20, Issue:12

    Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Analgesics, Opioid; Antiemetics; Drug Combinations; Fe

2019
Patient education videos for elective colorectal surgery: results of a randomized controlled trial.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2013, Volume: 15, Issue:11

    Topics: Acetaminophen; Aged; Analgesia, Epidural; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-St

2013
Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial.
    Lancet (London, England), 2014, Feb-22, Volume: 383, Issue:9918

    Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Antiemetics; Double-Blind Method;

2014
Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial.
    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2014, Volume: 24, Issue:7

    Topics: Acetaminophen; Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Analgesics,

2014
GSK2374697, a novel albumin-binding domain antibody (AlbudAb), extends systemic exposure of exendin-4: first study in humans--PK/PD and safety.
    Clinical pharmacology and therapeutics, 2014, Volume: 96, Issue:6

    Topics: Acetaminophen; Adult; Aged; Antibodies; Blood Glucose; Exenatide; Female; Gastric Emptying; Glucagon

2014
A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement.
    Current medical research and opinion, 2015, Volume: 31, Issue:1

    Topics: Acetaminophen; Acute Pain; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Arthroplasty, Replace

2015
Randomized, double-blind, placebo-controlled study of the efficacy and safety of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen tablets for acute postoperative pain.
    The Physician and sportsmedicine, 2015, Volume: 43, Issue:2

    Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Delayed-Action Prepa

2015
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials.
    BMC pharmacology & toxicology, 2015, Nov-27, Volume: 16

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action

2015
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials.
    BMC pharmacology & toxicology, 2015, Nov-27, Volume: 16

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action

2015
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials.
    BMC pharmacology & toxicology, 2015, Nov-27, Volume: 16

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action

2015
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials.
    BMC pharmacology & toxicology, 2015, Nov-27, Volume: 16

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action

2015
Transdermal Buprenorphine Relieves Neuropathic Pain: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial in Diabetic Peripheral Neuropathic Pain.
    Diabetes care, 2016, Volume: 39, Issue:9

    Topics: Acetaminophen; Administration, Cutaneous; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid;

2016
A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy.
    The Clinical journal of pain, 2010, Volume: 26, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Child

2010
Treatment with acetaminophen/paracetamol or ibuprofen alleviates post-dose symptoms related to intravenous infusion with zoledronic acid 5 mg.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012, Volume: 23, Issue:2

    Topics: Acetaminophen; Aged; Arthralgia; Body Temperature; Bone Density Conservation Agents; Diphosphonates;

2012
The analgesic effect of continuous subacromial bupivacaine infusion after arthroscopic shoulder surgery: a randomized controlled trial.
    Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:2

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Arthro

2012
Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain.
    Current medical research and opinion, 2012, Volume: 28, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Dizziness; Double-Blind Method; Drug Admi

2012
Acetaminophen improves analgesia but does not reduce opioid requirement after major spine surgery in children and adolescents.
    Spine, 2012, Sep-15, Volume: 37, Issue:20

    Topics: Acetaminophen; Administration, Intravenous; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid

2012
Tramadol/acetaminophen combination as add-on therapy in the treatment of patients with ankylosing spondylitis.
    Clinical rheumatology, 2013, Volume: 32, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St

2013
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
    Archives of gynecology and obstetrics, 2013, Volume: 288, Issue:1

    Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An

2013
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
    Archives of gynecology and obstetrics, 2013, Volume: 288, Issue:1

    Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An

2013
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
    Archives of gynecology and obstetrics, 2013, Volume: 288, Issue:1

    Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An

2013
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
    Archives of gynecology and obstetrics, 2013, Volume: 288, Issue:1

    Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An

2013
Adverse effects of superactivated charcoal administered to healthy volunteers.
    Hawaii medical journal, 2002, Volume: 61, Issue:11

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Charcoal; Constipation; Drug Overdose; Femal

2002
A double-blind placebo-controlled comparison of tramadol/acetaminophen and tramadol in patients with postoperative dental pain.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Dizziness; Double-Bl

2004
The delay of gastric emptying induced by remifentanil is not influenced by posture.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Area Under Curve; Blood Gas Anal

2004
The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.
    Annals of emergency medicine, 2005, Volume: 45, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Anaphylaxis; Aspartate Aminotransferases

2005
Long-term tolerability of tramadol LP, a new once-daily formulation, in patients with osteoarthritis or low back pain.
    Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:2

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Drug Administration Sche

2005
Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial.
    Headache, 2005, Volume: 45, Issue:8

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-

2005
Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury.
    Annals of emergency medicine, 2005, Volume: 46, Issue:4

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dizziness; Female; Humans

2005
Effects of repeated-dose isradipine on the abuse liability of cocaine.
    Experimental and clinical psychopharmacology, 2005, Volume: 13, Issue:4

    Topics: Acetaminophen; Administration, Oral; Adult; Analysis of Variance; Arrhythmias, Cardiac; Calcium Chan

2005
[Evaluation of postoperative analgesia with continuous iliofascial nerve sheath block after total hip arthroplasty replacement: a pilot study].
    Annales francaises d'anesthesie et de reanimation, 2007, Volume: 26, Issue:2

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics, Non-Narco

2007
Comparison of oral prednisolone/paracetamol and oral indomethacin/paracetamol combination therapy in the treatment of acute goutlike arthritis: a double-blind, randomized, controlled trial.
    Annals of emergency medicine, 2007, Volume: 49, Issue:5

    Topics: Abdominal Pain; Acetaminophen; Acute Disease; Administration, Oral; Aged; Aged, 80 and over; Analges

2007
Oral naproxen but not oral paracetamol reduces the need for rescue analgesic after adenoidectomy in children.
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:6

    Topics: Acetaminophen; Adenoidectomy; Administration, Inhalation; Administration, Oral; Analgesics; Anti-Inf

2007
Report of a double-blind crossover study to compare flurbiprofen with paracetamol in the treatment of primary dysmenorrhoea.
    The Journal of international medical research, 1983, Volume: 11 Suppl 2

    Topics: Acetaminophen; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Flurbiprofen; Hu

1983
Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques.
    Paediatric anaesthesia, 1995, Volume: 5, Issue:3

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recove

1995
The effect of post-operative diet on recovery in the first twelve hours after tonsillectomy and adenoidectomy.
    International journal of pediatric otorhinolaryngology, 1995, Volume: 31, Issue:2-3

    Topics: Acetaminophen; Adenoidectomy; Adolescent; Beverages; Child; Child Behavior; Child, Preschool; Diet;

1995
Pretreatment regimens for adverse events related to infusion of amphotericin B.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 20, Issue:4

    Topics: Acetaminophen; Adrenal Cortex Hormones; Amphotericin B; Diphenhydramine; Fever; Headache; Heparin; H

1995
Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy.
    Anesthesiology, 1994, Volume: 81, Issue:4

    Topics: Acetaminophen; Antiemetics; Child; Child, Preschool; Double-Blind Method; Droperidol; Female; Humans

1994
Effects of acetaminophen on adverse effects of influenza vaccination in health care workers.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1993, Nov-15, Volume: 149, Issue:10

    Topics: Acetaminophen; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Influenza Vacc

1993
Prophylactic paracetamol for analgesia after vaginal termination of pregnancy.
    Anaesthesia and intensive care, 1993, Volume: 21, Issue:1

    Topics: Abortion, Induced; Acetaminophen; Ambulatory Surgical Procedures; Analgesia; Analgesics; Anesthesia,

1993
Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy.
    European journal of anaesthesiology, 1993, Volume: 10, Issue:2

    Topics: Acetaminophen; Adult; Ambulatory Care; Diclofenac; Double-Blind Method; Female; Fentanyl; Humans; In

1993
The use of ondansetron in the treatment of nausea and vomiting associated with acetaminophen poisoning.
    Journal of toxicology. Clinical toxicology, 1996, Volume: 34, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antiemetics; Humans; Injections, I

1996
Analgesic efficacy of paracetamol in children using tonsillectomy as a pain model.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:6

    Topics: Acetaminophen; Administration, Oral; Adolescent; Ambulatory Surgical Procedures; Analgesics, Non-Nar

1996
Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol.
    Ophthalmology, 1997, Volume: 104, Issue:3

    Topics: Acetaminophen; Administration, Rectal; Analgesia; Analgesics; Anesthesia Recovery Period; Child; Chi

1997
Efficacy of ipecac during the first hour after drug ingestion in human volunteers.
    Journal of toxicology. Clinical toxicology, 1997, Volume: 35, Issue:6

    Topics: Acetaminophen; Adult; Area Under Curve; Biological Availability; Chromatography, High Pressure Liqui

1997
Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:2

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Analgesia, Patient-Cont

1998
Treatment of severe, disabling migraine attacks in an over-the-counter population of migraine sufferers: results from three randomized, placebo-controlled studies of the combination of acetaminophen, aspirin, and caffeine.
    Cephalalgia : an international journal of headache, 1999, Volume: 19, Issue:7

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Caffeine; Double-Blind Method; D

1999
Comparison of intravenous patient-controlled analgesia with tramadol versus morphine after microvascular breast reconstruction.
    European journal of anaesthesiology, 2000, Volume: 17, Issue:7

    Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthes

2000
Double-blind randomized study of tramadol vs. paracetamol in analgesia after day-case tonsillectomy in children.
    European journal of anaesthesiology, 2000, Volume: 17, Issue:9

    Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Opioid; Child;

2000
Comparison of a fixed combination of domperidone and paracetamol (Domperamol) with sumatriptan 50 mg in moderate to severe migraine: a randomised UK primary care study.
    Current medical research and opinion, 2000, Volume: 16, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cost-Benefit Analysis; Cross-Over Studies; Domperido

2000
Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen.
    Annals of the rheumatic diseases, 1975, Volume: 34, Issue:5

    Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Dyspepsia; Female; Humans;

1975
Feprazone, a new anti-inflammatory agent. Studies of potency and gastrointestinal tolerance.
    Annals of the rheumatic diseases, 1975, Volume: 34, Issue:2

    Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Digestive System; Female; F

1975
The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextropropoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips.
    Current medical research and opinion, 1992, Volume: 13, Issue:1

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Chronic Disease; Codeine; Delayed-Action Preparations

1992
[Effect of medical vagotomy on the CDDP induced nausea and vomiting evaluated by the chemotherapy-vomiting time (CV time)].
    Nihon Sanka Fujinka Gakkai zasshi, 1988, Volume: 40, Issue:9

    Topics: Acetaminophen; Adult; Cisplatin; Female; Humans; Metoclopramide; Middle Aged; Nausea; Ovarian Neopla

1988
Migraine treated with an antihistamine-analgesic combination.
    The Practitioner, 1973, Volume: 211, Issue:263

    Topics: Acetaminophen; Adolescent; Adult; Clinical Trials as Topic; Codeine; Cyclizine; Ergotamine; Female;

1973

Other Studies

30 other studies available for acetaminophen and Nausea

ArticleYear
[Unusual cause of a PCT-elevation].
    Deutsche medizinische Wochenschrift (1946), 2021, Volume: 146, Issue:12

    Topics: Abdominal Pain; Acetaminophen; Acetylcysteine; Adult; Diagnosis, Differential; Female; Humans; Nause

2021
Around Manaslu Ultramarathon: Diarrhea Is Still the King.
    Wilderness & environmental medicine, 2017, Volume: 28, Issue:4

    Topics: Acetaminophen; Acetazolamide; Altitude; Altitude Sickness; Analgesics, Non-Narcotic; Anti-Bacterial

2017
Case 6-2019: A 29-Year-Old Woman with Nausea, Vomiting, and Diarrhea.
    The New England journal of medicine, 2019, 02-21, Volume: 380, Issue:8

    Topics: Acetaminophen; Adult; Buprenorphine; Cocaine-Related Disorders; Diagnosis, Differential; Diarrhea; D

2019
Suboptimal pain treatment after craniotomy.
    Danish medical journal, 2013, Volume: 60, Issue:2

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Craniotomy; Female; Humans

2013
Infusion technique of hematopoietic progenitor cells and related adverse events (CME).
    Transfusion, 2014, Volume: 54, Issue:8

    Topics: Acetaminophen; Adolescent; Adult; Aged; Blood Preservation; Child; Child, Preschool; Cryopreservatio

2014
[Footballer's migraine instead of concussion].
    Nederlands tijdschrift voor geneeskunde, 2014, Volume: 158

    Topics: Acetaminophen; Adult; Antiemetics; Brain Concussion; Diagnosis, Differential; Humans; Male; Migraine

2014
Association between gastrointestinal manifestations following acetaminophen poisoning and outcome in 291 acetaminophen poisoning patients.
    Pharmacoepidemiology and drug safety, 2010, Volume: 19, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Induced Liver Injury; C

2010
A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose.
    Clinical toxicology (Philadelphia, Pa.), 2010, Volume: 48, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Drug Administration Routes; Drug Overdose; Humans; Infus

2010
Spontaneous intracerebral hemorrhage associated with ingestion of isometheptine containing anti-migraine medication.
    Clinical neurology and neurosurgery, 2011, Volume: 113, Issue:2

    Topics: Acetaminophen; Adult; Antipyrine; Cerebral Hemorrhage; Chloral Hydrate; Drug Combinations; Emergency

2011
Paracetamol and simvastatin: a potential interaction resulting in hepatotoxicity.
    Medicina (Kaunas, Lithuania), 2012, Volume: 48, Issue:7

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Coronary Artery Bypass; Cytochrome P-450 CYP3A; Drug

2012
[STUDIES OF THE EFFICACY OF A COMBINATION OF A MUSCLE RELAXANT, AN ANALGESIC AND OF PREDNISOLONE IN THE ILLNESS OF RHEUMATIC TYPE DISORDERS].
    Wiener medizinische Wochenschrift (1946), 1964, Jul-04, Volume: 114

    Topics: Acetaminophen; Analgesics; Drug Therapy; Geriatrics; Heartburn; Humans; Muscle Relaxants, Central; N

1964
Acetadote (intravenous acetylcysteine): adverse effects more significant than with oral acetylcysteine.
    Journal of emergency nursing, 2006, Volume: 32, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Antidotes; Drug Interactions; Drug Overdose; Em

2006
[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine].
    Masui. The Japanese journal of anesthesiology, 2007, Volume: 56, Issue:11

    Topics: Acetaminophen; Anesthetics, Intravenous; Aspirin; Chlorpheniramine; Cholecystectomy, Laparoscopic; D

2007
Effect of migraine attacks on paracetamol absorption.
    British journal of clinical pharmacology, 1984, Volume: 18, Issue:6

    Topics: Acetaminophen; Adult; Female; Humans; Intestinal Absorption; Kinetics; Middle Aged; Migraine Disorde

1984
[Benoxaprofen in the treatment of spondylosis and spondylarthrosis (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1981, Oct-09, Volume: 123, Issue:41

    Topics: Acetaminophen; Adult; Benzoxazoles; Drug Evaluation; Female; Humans; Joint Diseases; Male; Middle Ag

1981
A double blind study of metoclopramide in the treatment of migraine attacks.
    Journal of neurology, neurosurgery, and psychiatry, 1980, Volume: 43, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Aged; Diazepam; Double-Blind Method; Drug Therapy, Combination; Fe

1980
Ondansetron for treating nausea and vomiting in the poisoned patient.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:3

    Topics: Acetaminophen; Adolescent; Charcoal; Colchicine; Drug Overdose; Female; Humans; Nausea; Ondansetron;

1994
Paracetamol poisoning and hepatotoxicity in Chinese--the Prince of Wales Hospital (Hong Kong) experience.
    Singapore medical journal, 1993, Volume: 34, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Chi

1993
Supportive care during aldesleukin therapy for patients infected with human immunodeficiency virus.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1997, May-15, Volume: 54, Issue:10

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antiemetics; Female; Fever; HIV Infections; Humans;

1997
Additive analgesia without opioid side effects.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2000, Volume: 21, Issue:7

    Topics: Acetaminophen; Ambulatory Care; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflam

2000
Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers.
    American journal of physiology. Endocrinology and metabolism, 2001, Volume: 281, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; Area Under Curve; Blood Glucose; Depression

2001
[Acute kidney failure caused by paracetamol poisoning].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2001, Volume: 21, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Blood Coagulation Tests; Chemical and Drug Induced Liver

2001
Pain control in endodontics.
    Dental clinics of North America, 1979, Volume: 23, Issue:4

    Topics: Acetaminophen; Analgesics; Aspirin; Cellulitis; Codeine; Dextropropoxyphene; Humans; Nausea; Pain; P

1979
Purging with paracetamol: report of four cases.
    BMJ (Clinical research ed.), 1992, Sep-12, Volume: 305, Issue:6854

    Topics: Acetaminophen; Adolescent; Adult; Body Image; Body Weight; Bulimia; Female; Humans; Nausea; Substanc

1992
Is fentanyl effective for postoperative analgesia in day-surgery?
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesia; Anesthesia

1992
Epidural morphine for analgesia after caesarean section: a report of 4880 patients.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:6

    Topics: Acetaminophen; Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean S

1990
Epidural morphine for analgesia after caesarean section: a report of 4880 patients.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:6

    Topics: Acetaminophen; Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean S

1990
Epidural morphine for analgesia after caesarean section: a report of 4880 patients.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:6

    Topics: Acetaminophen; Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean S

1990
Epidural morphine for analgesia after caesarean section: a report of 4880 patients.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:6

    Topics: Acetaminophen; Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean S

1990
Treatment of common minor ailments.
    British medical journal (Clinical research ed.), 1986, Dec-13, Volume: 293, Issue:6561

    Topics: Acetaminophen; Antacids; Antiemetics; Aspirin; Dyspepsia; Female; Heartburn; Histamine H1 Antagonist

1986
Acetaminophen poisoning.
    Pediatrics, 1973, Volume: 52, Issue:6

    Topics: Acetaminophen; Adolescent; Catalogs, Drug as Topic; Charcoal; Chemical and Drug Induced Liver Injury

1973
Analgesic nephropathy associated with paracetamol.
    Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:9

    Topics: Acetaminophen; Codeine; Female; Headache; Humans; Kidney Diseases; Middle Aged; Nausea; Phenacetin;

1973
Migraine--treatment of acute attack.
    British medical journal, 1971, Jun-26, Volume: 2, Issue:5764

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Antiemetics; Aspirin; Child; Ergotamine; Female;

1971