acetaminophen and Nausea
acetaminophen has been researched along with Nausea in 83 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12." | 9.30 | Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi ( Chou, JC; Daniels, SE; Giannakopoulos, HE; Granquist, EJ; Levin, LM; Maibach, H; Muse, DD; Oreadi, D; Papas, AS; Patrick, K; Schachtel, BP; Zuniga, JR, 2019) |
| "A fixed-dose combination biphasic immediate-release (IR)/extended-release (ER) hydrocodone bitartrate (HB)/acetaminophen (APAP) tablet is being developed for the management of acute pain severe enough to require opioid treatment and for which alternative treatment options are inadequate." | 9.20 | Randomized, double-blind, placebo-controlled study of the efficacy and safety of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen tablets for acute postoperative pain. ( Barrett, T; Chen, Y; Giuliani, MJ; Kostenbader, K; Margulis, R; Singla, N; Young, JL; Zheng, Y, 2015) |
| " Vomiting, retching, or need for rescue antiemetic treatment at 2 h was reported in 39 of 108 patients assigned to the shorter modified protocol compared with 71 of 109 allocated to the standard acetylcysteine regimen (adjusted odds ratio 0·26, 97·5% CI 0·13-0·52; p<0·0001), and in 45 of 109 patients who received ondansetron compared with 65 of 108 allocated placebo (0·41, 0·20-0·80; p=0·003)." | 9.19 | Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. ( Bateman, DN; Butcher, I; Cooper, JG; Coyle, J; Dear, JW; Eddleston, M; Gray, A; Lewis, SC; Rodriguez, A; Sandilands, EA; Thanacoody, HK; Thomas, SH; Veiraiah, A; Vliegenthart, AD; Webb, DJ, 2014) |
| "Intravenous acetaminophen plus oral oxycodone is as effective as intravenous morphine sulfate in acute pain control in emergency department but with a less desirable safety profile." | 9.19 | Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014) |
| " The objective of this study was to investigate the efficacy and safety of an extended-release, twice-daily fixed combination of 75 mg tramadol/650 mg paracetamol (DDS-06C) in the treatment of moderate-to-severe pain, using acute low back pain as a model." | 9.16 | Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain. ( Bouchard, S; Lasko, B; Levitt, RJ; Rainsford, KD; Robertson, S; Rozova, A, 2012) |
| "Long-term treatment with tramadol LP once daily is generally safe in patients with osteoarthritis or refractory low back pain." | 9.11 | Long-term tolerability of tramadol LP, a new once-daily formulation, in patients with osteoarthritis or low back pain. ( Coffiner, M; Fontaine, D; Malonne, H; Peretz, A; Sereno, A; Sonet, B; Vanderbist, F, 2005) |
| "We performed a prospective, single arm, observational study examining the effectiveness of the 5HT3 receptor antagonist ondansetron in the management if nausea and vomiting associated with acetaminophen poisoning." | 9.08 | The use of ondansetron in the treatment of nausea and vomiting associated with acetaminophen poisoning. ( Chen, R; Clark, RF; Harchelroad, F; Johnson, CL; Williams, SR, 1996) |
| " This study has attempted to assess postoperative analgesic consumption and nausea and vomiting after general anaesthesia for tonsillectomy using either paracetamol premedication, paracetamol plus a NSAID or intravenous morphine to provide postoperative analgesia." | 9.08 | Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques. ( Mather, SJ; Peutrell, JM, 1995) |
| "A prospective, comparative, randomized study to assess rectal acetaminophen (n = 45) to intravenous fentanyl-droperidol (n = 45) to resolve recovery profile, emesis rate, and adequacy of analgesia in a pediatric strabismus repair population was performed, with standardization of the anesthetic technique." | 9.08 | Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol. ( Cruz, OA; Krock, JL; Padda, GS, 1997) |
| "At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy." | 9.07 | Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993) |
| "Doses of 600 mg and 1200 mg of D(-)penicillamine daily were superior to a standard regimen of therapy in rheumatoid arthritis." | 9.04 | Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen. ( Davies, J; Dixon, AJ; Dormandy, TL; Hamilton, EB; Holt, PJ; Mason, RM; Thompson, M; Weber, JC; Zutshi, DW, 1975) |
| "The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement." | 7.74 | [Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine]. ( Abe, F; Furuya, A; Nagamine, N; Nonaka, A; Suzuki, S, 2007) |
| "To describe the efficacy of ondansetron for the treatment of poisoning-associated vomiting in two patients following drug intoxication." | 7.69 | Ondansetron for treating nausea and vomiting in the poisoned patient. ( Marx, CM; Reed, MD, 1994) |
| " There was no difference in the mean frequency or dosage of rescue medication required by both groups, and the majority of patients in both the TA-ER and TA-IR groups rated their pain improvement as 'much' or 'somewhat better'." | 6.80 | A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement. ( Bin, SI; Chang, N; Cho, SD; Choi, CH; Ha, CW; Kang, SB; Kyung, HS; Lee, JH; Lee, MC; Park, YB; Rhim, HY; Seo, SS, 2015) |
| "The acetaminophen group had lower pain scores on Day 1 (2." | 6.69 | Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain. ( Fox, L; McGuinnety, M; Schug, SA; Sidebotham, DA; Thomas, J, 1998) |
| "To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12." | 5.30 | Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi ( Chou, JC; Daniels, SE; Giannakopoulos, HE; Granquist, EJ; Levin, LM; Maibach, H; Muse, DD; Oreadi, D; Papas, AS; Patrick, K; Schachtel, BP; Zuniga, JR, 2019) |
| "A fixed-dose combination biphasic immediate-release (IR)/extended-release (ER) hydrocodone bitartrate (HB)/acetaminophen (APAP) tablet is being developed for the management of acute pain severe enough to require opioid treatment and for which alternative treatment options are inadequate." | 5.20 | Randomized, double-blind, placebo-controlled study of the efficacy and safety of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen tablets for acute postoperative pain. ( Barrett, T; Chen, Y; Giuliani, MJ; Kostenbader, K; Margulis, R; Singla, N; Young, JL; Zheng, Y, 2015) |
| " Vomiting, retching, or need for rescue antiemetic treatment at 2 h was reported in 39 of 108 patients assigned to the shorter modified protocol compared with 71 of 109 allocated to the standard acetylcysteine regimen (adjusted odds ratio 0·26, 97·5% CI 0·13-0·52; p<0·0001), and in 45 of 109 patients who received ondansetron compared with 65 of 108 allocated placebo (0·41, 0·20-0·80; p=0·003)." | 5.19 | Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. ( Bateman, DN; Butcher, I; Cooper, JG; Coyle, J; Dear, JW; Eddleston, M; Gray, A; Lewis, SC; Rodriguez, A; Sandilands, EA; Thanacoody, HK; Thomas, SH; Veiraiah, A; Vliegenthart, AD; Webb, DJ, 2014) |
| "Intravenous acetaminophen plus oral oxycodone is as effective as intravenous morphine sulfate in acute pain control in emergency department but with a less desirable safety profile." | 5.19 | Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. ( Abbasi, S; Farsi, D; Fathi, M; Ghalyaie, AH; Hafezimoghadam, P; Zare, MA, 2014) |
| " The objective of this study was to investigate the efficacy and safety of an extended-release, twice-daily fixed combination of 75 mg tramadol/650 mg paracetamol (DDS-06C) in the treatment of moderate-to-severe pain, using acute low back pain as a model." | 5.16 | Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain. ( Bouchard, S; Lasko, B; Levitt, RJ; Rainsford, KD; Robertson, S; Rozova, A, 2012) |
| "A randomized, placebo-controlled, double-blind study to evaluate the effect of intravenously (IV) administered acetaminophen on postoperative pain in children and adolescents undergoing surgery for idiopathic scoliosis or spondylolisthesis." | 5.16 | Acetaminophen improves analgesia but does not reduce opioid requirement after major spine surgery in children and adolescents. ( Hartikainen, T; Helenius, I; Hiller, A; Kaukonen, M; Korpela, R; Meretoja, OA; Neuvonen, PJ; Nurmi, E; Taivainen, T, 2012) |
| "Our aim was to show the efficacy of naproxen and paracetamol with and without pethidine on pain and nausea and vomiting after adenoidectomy." | 5.12 | Oral naproxen but not oral paracetamol reduces the need for rescue analgesic after adenoidectomy in children. ( Korpela, R; Laakso, E; Meretoja, OA; Silvola, J, 2007) |
| "Long-term treatment with tramadol LP once daily is generally safe in patients with osteoarthritis or refractory low back pain." | 5.11 | Long-term tolerability of tramadol LP, a new once-daily formulation, in patients with osteoarthritis or low back pain. ( Coffiner, M; Fontaine, D; Malonne, H; Peretz, A; Sereno, A; Sonet, B; Vanderbist, F, 2005) |
| "There was no statistical difference in the mean reduction in pain score between any of the combinations at any point, although combination therapy was the first to reach a clinically significant reduction in pain score (<13 mm), and diclofenac-paracetamol combinations consistently produced a greater reduction in mean pain score than either nonsteroidal antiinflammatory drugs or paracetamol alone." | 5.11 | Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury. ( Lam, PK; Man, SY; Rainer, TH; Woo, WW, 2005) |
| " The aim of this study was to compare the effectiveness and tolerability of a fixed combination of domperidone and paracetamol (Domperamol; Servier), which has anti-nauseant and anti-emetic activity, with sumatriptan 50 mg in moderate to severe migraine." | 5.09 | Comparison of a fixed combination of domperidone and paracetamol (Domperamol) with sumatriptan 50 mg in moderate to severe migraine: a randomised UK primary care study. ( Ball, K; Dowson, A; Haworth, D, 2000) |
| " This study has attempted to assess postoperative analgesic consumption and nausea and vomiting after general anaesthesia for tonsillectomy using either paracetamol premedication, paracetamol plus a NSAID or intravenous morphine to provide postoperative analgesia." | 5.08 | Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques. ( Mather, SJ; Peutrell, JM, 1995) |
| "Infusion-related adverse events (IRAEs) such as nausea, vomiting, fever, chills, and thrombophlebitis that are associated with amphotericin B therapy often lead clinicians to prescribe a number of adjunctive pretreatment medications in an attempt to reduce the incidence and severity of these events." | 5.08 | Pretreatment regimens for adverse events related to infusion of amphotericin B. ( Cleary, JD; Goodwin, SD; Grasela, TH; Taylor, JW; Walawander, CA, 1995) |
| "We performed a prospective, single arm, observational study examining the effectiveness of the 5HT3 receptor antagonist ondansetron in the management if nausea and vomiting associated with acetaminophen poisoning." | 5.08 | The use of ondansetron in the treatment of nausea and vomiting associated with acetaminophen poisoning. ( Chen, R; Clark, RF; Harchelroad, F; Johnson, CL; Williams, SR, 1996) |
| "A prospective, comparative, randomized study to assess rectal acetaminophen (n = 45) to intravenous fentanyl-droperidol (n = 45) to resolve recovery profile, emesis rate, and adequacy of analgesia in a pediatric strabismus repair population was performed, with standardization of the anesthetic technique." | 5.08 | Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol. ( Cruz, OA; Krock, JL; Padda, GS, 1997) |
| "At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy." | 5.07 | Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993) |
| "The full dose of acetaminophen significantly reduced the incidence of sore arm and nausea without affecting the antibody response." | 5.07 | Effects of acetaminophen on adverse effects of influenza vaccination in health care workers. ( Aoki, FY; Cheang, M; Hammond, GW; Murdzak, C; Seklà, LH; Wright, B; Yassi, A, 1993) |
| " Acetaminophen and meperidine were given for postoperative pain." | 5.07 | Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy. ( Furst, SR; Rodarte, A, 1994) |
| "Doses of 600 mg and 1200 mg of D(-)penicillamine daily were superior to a standard regimen of therapy in rheumatoid arthritis." | 5.04 | Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen. ( Davies, J; Dixon, AJ; Dormandy, TL; Hamilton, EB; Holt, PJ; Mason, RM; Thompson, M; Weber, JC; Zutshi, DW, 1975) |
| "The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement." | 3.74 | [Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine]. ( Abe, F; Furuya, A; Nagamine, N; Nonaka, A; Suzuki, S, 2007) |
| " Switching to an opioid combined with acetaminophen or aspirin does not result in greater analgesia, but increases the incidence of side effects such as drowsiness and nausea." | 3.70 | Additive analgesia without opioid side effects. ( Dionne, R, 2000) |
| "To describe the efficacy of ondansetron for the treatment of poisoning-associated vomiting in two patients following drug intoxication." | 3.69 | Ondansetron for treating nausea and vomiting in the poisoned patient. ( Marx, CM; Reed, MD, 1994) |
| "Postoperative pain was significantly less in the bupivacaine group at 240 and 360 min after the surgery." | 3.11 | Comparing the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children. ( Ayatollahi, V; Hosseini, H; Meybodian, M; Shariatmadari, M; Vaziribozorg, S, 2022) |
| " In both studies, a high-fat meal did not affect the Cmax for hydrocodone." | 2.80 | Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials. ( Devarakonda, K; Giuliani, MJ; Kostenbader, K; Young, JL, 2015) |
| " There was no difference in the mean frequency or dosage of rescue medication required by both groups, and the majority of patients in both the TA-ER and TA-IR groups rated their pain improvement as 'much' or 'somewhat better'." | 2.80 | A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement. ( Bin, SI; Chang, N; Cho, SD; Choi, CH; Ha, CW; Kang, SB; Kyung, HS; Lee, JH; Lee, MC; Park, YB; Rhim, HY; Seo, SS, 2015) |
| "Active disease was defined by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) for more than 3 at randomization." | 2.78 | Tramadol/acetaminophen combination as add-on therapy in the treatment of patients with ankylosing spondylitis. ( Chang, IC; Chang, JK; Lee, MY; Tsou, HK; Wei, JC; Yeo, K; Yu, CT, 2013) |
| " With the exception of constipation, scheduled analgesic dosing did not increase the frequency or severity of opioid-related adverse effects." | 2.75 | A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy. ( Holdridge-Zeuner, D; Lanier, B; Mahoney, K; Miaskowski, C; Paul, SM; Savedra, MC; Sutters, KA; Waite, S, 2010) |
| "Isradipine dose was 30 mg sustained release nightly plus 15 mg immediate release 2 hr before cocaine infusion." | 2.71 | Effects of repeated-dose isradipine on the abuse liability of cocaine. ( Ait-Daoud, N; Johnson, BA; Mauldin, JB; Murff, WL; Roache, JD; Thornton, JE; Wells, LT, 2005) |
| "Most people who experience migraine use OTC medications to treat their symptoms, but no head-to-head clinical trials comparing these agents with prescription migraine therapies have been published." | 2.71 | Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial. ( Baggish, J; Battikha, JP; Elkind, AH; Gallagher, RM; Goldstein, J; Hoffman, H; Saper, JR; Silberstein, SD; Smith, TR, 2005) |
| "Tramadol/APAP was superior to tramadol (P < 0." | 2.71 | A double-blind placebo-controlled comparison of tramadol/acetaminophen and tramadol in patients with postoperative dental pain. ( Fisher, A; Fricke, JR; Hewitt, DJ; Jordan, DM; Rosenthal, NR, 2004) |
| "When remifentanil was given, there were no significant differences between the two postures in maximal acetaminophen concentration (right side, 34 micromol." | 2.71 | The delay of gastric emptying induced by remifentanil is not influenced by posture. ( Thörn, SE; Walldén, J; Wattwil, M, 2004) |
| "Acetaminophen may have been blunted some adverse effects." | 2.70 | Adverse effects of superactivated charcoal administered to healthy volunteers. ( Sato, RL; Sumida, SM; Wong, JJ; Yamamoto, LG, 2002) |
| "The acetaminophen group had lower pain scores on Day 1 (2." | 2.69 | Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain. ( Fox, L; McGuinnety, M; Schug, SA; Sidebotham, DA; Thomas, J, 1998) |
| "When postoperative pain occurred, loading doses of either 10 mg tramadol or 1 mg morphine intravenous increments were administered in a double-blind fashion until the pain control was judged to be satisfactory by the patient." | 2.69 | Comparison of intravenous patient-controlled analgesia with tramadol versus morphine after microvascular breast reconstruction. ( Pitkänen, M; Rosenberg, PH; Silvasti, M; Svartling, N, 2000) |
| " This dosage of paracetamol is lower than the current recommended dosage, which is 40 mg kg(-1) loading dose followed by 20 mg kg(-1) 8 h(-1)." | 2.69 | Double-blind randomized study of tramadol vs. paracetamol in analgesia after day-case tonsillectomy in children. ( Dort, JP; Pendeville, PE; Veyckemans, F; Von Montigny, S, 2000) |
| " This corresponds to decreases in bioavailability of 67, 11, and 21%." | 2.68 | Efficacy of ipecac during the first hour after drug ingestion in human volunteers. ( Saincher, A; Sitar, DS; Tenenbein, M, 1997) |
| "Postoperative pain was reported in 35% of patients, with no significant difference between treated and control patients." | 2.67 | Prophylactic paracetamol for analgesia after vaginal termination of pregnancy. ( Ashley, J; Cade, L, 1993) |
| " Tolerance in terms of withdrawals or side-effect profile did not appear to the dosage of each preparation administered." | 2.67 | The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextropropoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips. ( Costello, F; Eves, MJ; James, IG; Lloyd, RS; Miller, AJ, 1992) |
| "Data on assessment and treatment of spinal cord compression are reviewed." | 2.40 | Management of pain and spinal cord compression in patients with advanced cancer. ACP-ASIM End-of-life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine. ( Abrahm, JL, 1999) |
| " The possible causes for the injury from ostensibly nontoxic drug levels appear to be either the induction by chronic alcohol intake of the cytochrome P-450 system responsible for converting acetaminophen to a toxic metabolite, or the effect of alcoholism and the associated malnutrition in reducing the glutathione concentration, responsible normally for preventing hepatotoxicity by conjugation with the toxic metabolite." | 2.37 | Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. ( Adler, E; Benjamin, SB; Cuccherini, BA; Seeff, LB; Zimmerman, HJ, 1986) |
| "Flushing was the most common type of AE followed by nausea and hypertension." | 1.40 | Infusion technique of hematopoietic progenitor cells and related adverse events (CME). ( Bryant, SC; Gastineau, DA; Greiner, CW; Hogan, WJ; Jacob, EK; Lingineni, RK; Mohr, A; Mulay, SB; Padley, D, 2014) |
| "Trauma triggered migraine is seen more frequently in children, adolescents and young adults." | 1.40 | [Footballer's migraine instead of concussion]. ( Borggreve, AG; Haan, J; Lansink, JG; van Oosterhout, WP, 2014) |
| "Simvastatin is a substrate of CYP3A4 enzyme." | 1.38 | Paracetamol and simvastatin: a potential interaction resulting in hepatotoxicity. ( Gumbrevičius, G; Stankevičius, E; Sveikata, A; Sveikatienė, R, 2012) |
| "Acetaminophen poisoning is a common clinical problem, and early identification of patients with more severe poisoning is key to improving outcomes." | 1.36 | Association between gastrointestinal manifestations following acetaminophen poisoning and outcome in 291 acetaminophen poisoning patients. ( Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH, 2010) |
| " The primary safety outcome was the percentage of patients with NAC-related adverse events." | 1.36 | A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose. ( Aguilera, E; Al-Helial, M; Arnold, T; Bebarta, VS; Bogdan, G; Buchanan, J; Clark, RF; Dart, R; Delgado, J; Froberg, B; Haur, W; Heard, K; Hoppe, J; Kao, L; Kokko, J; Lares, C; Lavonas, E; McDonagh, J; Mendoza, C; Mlynarchek, S; O'Malley, G; Odujebe, O; Qi, M; Rhyee, S; Stanford, C; Tan, HH; Tran, NN; Varney, S; Zosel, A, 2010) |
| "The morphine was administered as a single bolus, following delivery, in doses ranging from 2 to 5 mg." | 1.28 | Epidural morphine for analgesia after caesarean section: a report of 4880 patients. ( Douglas, MJ; Fuller, JG; McMorland, GH; Palmer, L, 1990) |
| " The non-steroid antirheumatic benoxaprofen was used alone in a dosage of a 1 x 600 mg tablet daily." | 1.26 | [Benoxaprofen in the treatment of spondylosis and spondylarthrosis (author's transl)]. ( Hevelke, G; Schilling, E, 1981) |
| "One hundred and fifty patients with migraine attacks attending the Copenhagen acute migraine clinic were treated either with metoclopramide 10 mg i." | 1.26 | A double blind study of metoclopramide in the treatment of migraine attacks. ( Aebelholt-Krabbe, A; Melgaard, B; Olesen, J; Tfelt-Hansen, P; Veilis, B, 1980) |
Research
Studies (83)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (18.07) | 18.7374 |
| 1990's | 21 (25.30) | 18.2507 |
| 2000's | 19 (22.89) | 29.6817 |
| 2010's | 25 (30.12) | 24.3611 |
| 2020's | 3 (3.61) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hosseini, H | 1 |
| Shariatmadari, M | 1 |
| Ayatollahi, V | 1 |
| Vaziribozorg, S | 1 |
| Meybodian, M | 1 |
| Anter, ME | 1 |
| Abdel Attey Saleh, S | 1 |
| Shawkey Allam, S | 1 |
| Mohamed Nofal, A | 1 |
| Vogelbacher, LC | 1 |
| Thimme, R | 1 |
| Subedi, Y | 1 |
| Zuniga, JR | 1 |
| Papas, AS | 1 |
| Daniels, SE | 1 |
| Patrick, K | 1 |
| Muse, DD | 1 |
| Oreadi, D | 1 |
| Giannakopoulos, HE | 1 |
| Granquist, EJ | 1 |
| Levin, LM | 1 |
| Chou, JC | 1 |
| Maibach, H | 1 |
| Schachtel, BP | 1 |
| Walley, AY | 1 |
| Wakeman, SE | 1 |
| Eng, G | 1 |
| Hansen, MS | 1 |
| Brennum, J | 1 |
| Moltke, FB | 1 |
| Dahl, JB | 1 |
| Ihedioha, U | 1 |
| Vaughan, S | 1 |
| Mastermann, J | 1 |
| Singh, B | 1 |
| Chaudhri, S | 1 |
| Bateman, DN | 1 |
| Dear, JW | 1 |
| Thanacoody, HK | 1 |
| Thomas, SH | 1 |
| Eddleston, M | 1 |
| Sandilands, EA | 1 |
| Coyle, J | 1 |
| Cooper, JG | 1 |
| Rodriguez, A | 1 |
| Butcher, I | 1 |
| Lewis, SC | 1 |
| Vliegenthart, AD | 1 |
| Veiraiah, A | 1 |
| Webb, DJ | 1 |
| Gray, A | 1 |
| Zare, MA | 1 |
| Ghalyaie, AH | 1 |
| Fathi, M | 1 |
| Farsi, D | 1 |
| Abbasi, S | 1 |
| Hafezimoghadam, P | 1 |
| Mulay, SB | 1 |
| Greiner, CW | 1 |
| Mohr, A | 1 |
| Bryant, SC | 1 |
| Lingineni, RK | 1 |
| Padley, D | 1 |
| Hogan, WJ | 1 |
| Gastineau, DA | 1 |
| Jacob, EK | 1 |
| O'Connor-Semmes, RL | 1 |
| Lin, J | 1 |
| Hodge, RJ | 1 |
| Andrews, S | 1 |
| Chism, J | 1 |
| Choudhury, A | 1 |
| Nunez, DJ | 1 |
| Park, YB | 1 |
| Ha, CW | 1 |
| Cho, SD | 1 |
| Lee, MC | 1 |
| Lee, JH | 1 |
| Seo, SS | 1 |
| Kang, SB | 1 |
| Kyung, HS | 1 |
| Choi, CH | 1 |
| Chang, N | 1 |
| Rhim, HY | 1 |
| Bin, SI | 1 |
| Lansink, JG | 1 |
| van Oosterhout, WP | 1 |
| Borggreve, AG | 1 |
| Haan, J | 1 |
| Singla, N | 1 |
| Margulis, R | 1 |
| Kostenbader, K | 2 |
| Zheng, Y | 1 |
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Clinical Trials (16)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Intravenous Paracetamol in Manament of Labour Pain in a Low Resource Setting[NCT04744727] | 96 participants (Actual) | Interventional | 2019-03-01 | Completed | |||
| Comparison of the Analgesic Effects of Scalp Nerve Block and Intravenous Ibuprofen Applications Under the Guidance of Nociception Level Index (NoL) in Patients Undergoing Elective Supratentorial Craniotomy[NCT05763836] | Phase 4 | 102 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | ||
| A Randomised Trial to Assess the Effectiveness of Pre-treatment With Ondansetron at Reducing Nausea and Vomiting in Patients Treated With Either the Conventional Regimen or a Modified Regimen of Acetylcysteine for Paracetamol Poisoning[NCT01050270] | Phase 4 | 222 participants (Actual) | Interventional | 2010-09-30 | Completed | ||
| A Randomized, Active-Controlled, Parallel Group, Double-Blind Study to Compare the Efficacy and Safety of Tramadol HCl/Acetaminophen ER and IR in Subjects Who Complain of Moderate to Severe Postoperative Pain[NCT01814878] | Phase 3 | 320 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| An Open-Label, Randomized, Single-Dose, Three-Period Crossover Study to Evaluate the Pharmacokinetics, Bioavailability, and Safety of COV155 Administered in Normal, Healthy Subjects Under Fed (High- and Low-Fat Meal) and Fasted Conditions[NCT02561650] | Phase 1 | 48 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| An Open-Label, Randomized, Single-Dose, Three-Period Crossover Study to Evaluate the Pharmacokinetics, Bioavailability, and Safety of 3 Tablets of COV155 Administered in Normal, Healthy Subjects Under Fed (High- and Low-Fat Meal) and Fasted Conditions[NCT02561741] | Phase 1 | 30 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Home Care Management of Pediatric Pain[NCT00251628] | Phase 4 | 211 participants (Actual) | Interventional | 2000-06-30 | Completed | ||
| Randomized Control Trial of Ultrasound-Guided Erector Spinae Block Versus Shoulder Periarticular Anesthetic Infiltration for Pain Control After Arthroscopic Shoulder Surgery[NCT03691922] | 62 participants (Actual) | Interventional | 2019-07-06 | Completed | |||
| [NCT00643383] | Phase 3 | 277 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| Ultrasound-guided Transversus Abdominis Plane Block After Abdominal Hysterectomy: a Prospective Randomized Controlled Trial[NCT01153503] | 75 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| Bilateral Transversus Abdominis Plane Block With or Without Magnesium for Total Abdominal Hysterectomy With or Without Salpingo-oophorectomy: a Randomized Controlled Trial[NCT02680626] | Phase 4 | 86 participants (Actual) | Interventional | 2016-01-31 | Terminated (stopped due to Pfannenstiel hysterectomies are now rarely performed so cannot recruit eligible patients) | ||
| A Comparison of the Efficacy and Safety of ULTRACET® (Tramadol HCl/Acetaminophen) Versus ULTRAM® (Tramadol HCl) Versus Placebo in Subjects With Pain Following Oral Surgery[NCT00236483] | Phase 4 | 456 participants (Actual) | Interventional | 2002-11-30 | Completed | ||
| A Pilot Trial to Determine the Effective Dose of N-acetylcysteine for Opioid Reduction in Patients Undergoing Spine Surgery.[NCT04562597] | Phase 1/Phase 2 | 50 participants (Actual) | Interventional | 2021-01-20 | Completed | ||
| A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy[NCT01267136] | Phase 4 | 84 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Ropivacaine Through Continuous Infusion Versus Epidural Morphine for Postoperative Analgesia After Emergency Cesarean Section[NCT02410317] | Phase 3 | 101 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Randomized, Controlled, Double Blind, to Evaluate the Postpartum Analgesia With Epidural Morphine: Analgesic Effect of Two Different Doses Compared to Placebo[NCT04887649] | Phase 3 | 114 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Dosage of Rescue Medication Administered Because of Insufficient Pain Relief
The dosage of the rescue medication (rescue medications are medicines that are administered to the participants when the efficacy of the study drug is not satisfactory, or the effect of the study drug is too great and is likely to cause a hazard to the participant, or to manage an emergency situation) because of insufficient pain relief was measured after administration of the study drug. Rescue medications allowed were oral or injection of tramadol HCl (intramuscular or intravenous injection). (NCT01814878)
Timeframe: Baseline up to Day 3
| Intervention | Milligram (Mean) |
|---|---|
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 50.0 |
| Tramadol HCl/Acetaminophen IR | 51.7 |
Number of Doses of Rescue Medication Administered Because of Insufficient Pain Relief
The frequency of the rescue medication (rescue medications are medicines that are administered to the participants when the efficacy of the study drug is not satisfactory, or the effect of the study drug is too great and is likely to cause a hazard to the participant, or to manage an emergency situation) because of insufficient pain relief was measured after administration of the study drug. Rescue medications allowed were oral or injection of tramadol HCl (intramuscular or intravenous injection). (NCT01814878)
Timeframe: Baseline up to Day 3
| Intervention | Doses (Mean) |
|---|---|
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 2.1 |
| Tramadol HCl/Acetaminophen IR | 1.4 |
Patient Global Impression of Change (PGIC) Score
The PGIC was used to assess the degree of participant's overall improvement with treatment, and participants were instructed to assess how much the overall status had been improved after investigational product administration compared to baseline in 7 grades (1=Very much improved and B=Very much worsened). (NCT01814878)
Timeframe: Day 3
| Intervention | Units on scale (Mean) |
|---|---|
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 2.71 |
| Tramadol HCl/Acetaminophen IR | 2.60 |
Sum of Pain Intensity Difference (SPID) at Hour 48
The SPID is time-weighted sum of all observations of pain intensity difference (PID) collected at each measurement time point from Baseline to 48 hours. PID: Baseline pain intensity (PI) minus current PI; PI was assessed using 11-point numeric rating scale (NRS, 0=no pain to 10=worst pain imaginable). PI score ranges from 0-3 where 0=no pain and 3=severe pain. PI score of 0=NRS score of 0, PI score of 1=NRS score >=1 and <=3, PI score of 2=NRS score of >=4 and <=6 and PI score of 3=NRS score of >=7 and <=10. Total score for SPID at 48 hours (SPID48) ranges from -144 (worst) to 144 (best). (NCT01814878)
Timeframe: Hour 48
| Intervention | Units on scale (Mean) |
|---|---|
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 32.5 |
| Tramadol HCl/Acetaminophen IR | 37.2 |
Time to the First Rescue Medication Administered Because of Insufficient Pain Relief
The time until administration of the first rescue medication (rescue medications are medicines that are administered to the participants when the efficacy of the study drug is not satisfactory, or the effect of the study drug is too great and is likely to cause a hazard to the participant, or to manage an emergency situation) because of insufficient pain relief after administration of the study drug was recorded. Rescue medications allowed were oral or injection of tramadol HCl (intramuscular [directly into muscle] or intravenous injection [directly into vein]). (NCT01814878)
Timeframe: Baseline up to Day 3
| Intervention | Minutes (Mean) |
|---|---|
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 1339 |
| Tramadol HCl/Acetaminophen IR | 1212 |
Sum of Pain Intensity Difference (SPID) at Hour 6, 12 and 24
The SPID is time-weighted sum of all observations of PID collected at each measurement time point from Baseline to 24 hours. PID: Baseline PI minus current PI; PI was assessed using 11-point NRS, 0=no pain to 10=worst pain imaginable. PI score ranges from 0-3 where 0=no pain and 3=severe pain. PI score of 0=NRS score of 0, PI score of 1=NRS score >=1 and <=3, PI score of 2=NRS score of >=4 and <=6 and PI score of 3=NRS score of >=7 and <=10. Total score ranges from -18 (worst) to 18 (best) for SPID6, -36 (worst) to 36 (best) for SPID12 and -72 (worst) to 72 (best) for SPID24. (NCT01814878)
Timeframe: Hour 6, 12, 24
| Intervention | Units on scale (Mean) | ||
|---|---|---|---|
| Hour 6 | Hour 12 | Hour 24 | |
| Tramadol HCl/Acetaminophen IR | 3.9 | 8.1 | 17.6 |
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 3.6 | 7.0 | 14.6 |
Sum of Total Pain Relief and Sum of Pain Intensity Difference (SPRID)
The SPRID is sum of SPID and TOTPAR. In SPID, PI score ranges from 0-3 where 0=no pain and 3=severe pain. PI score of 0=NRS score of 0, PI score of 1=NRS score >=1 and <= 3, PI score of 2=NRS score of >=4 and <=6 and PI score of 3=NRS score of >=7 and <=10. In TOTPAR, pain relief score ranges from 0-4 (0=no change, 1=slight relief, 2=moderate relief, 3=fair relief, 4=pain resolved completely). Total score ranges from -18 (worst) to 42 (best) for SPRID6, -36 (worst) to 84 (best) for SPRID12, -72 (worst) to 168 (best) for SPRID24 and -144 (worst) to 336 (best) for SPRID48. (NCT01814878)
Timeframe: Hour 6, 12, 24, 48
| Intervention | Units on scale (Mean) | |||
|---|---|---|---|---|
| Hour 6 | Hour 12 | Hour 24 | Hour 48 | |
| Tramadol HCl/Acetaminophen IR | 10.9 | 23.1 | 49.1 | 97.0 |
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 9.6 | 19.6 | 41.8 | 85.9 |
Total Pain Relief (TOTPAR) Score
Pain relief was measured on a 5-point categorical scale of 0-4 (0=no change, 1=slight relief, 2=moderate relief, 3=fair relief, 4=pain resolved completely). TOTPAR was calculated as the time-weighted sum over all pain relief up to 48 hours. Total score ranges from 0 (worst) to 24 (best) for TOTPAR6, 0 (worst) to 48 (best) for TOTPAR12, 0 (worst) to 96 (best) for TOTPAR24 and 0 (worst) to 192 (best) for TOTPAR48. (NCT01814878)
Timeframe: Hour 6, 12, 24, 48
| Intervention | Units on scale (Mean) | |||
|---|---|---|---|---|
| Hour 6 | Hour 12 | Hour 24 | Hour 48 | |
| Tramadol HCl/Acetaminophen IR | 6.8 | 14.7 | 31.0 | 61.7 |
| Tramadol Hydrochloride (HCl)/Acetaminophen ER | 6.0 | 12.5 | 27.1 | 55.6 |
Morphine Consumption
Morphine consumption over the first 24 hours (NCT01153503)
Timeframe: 24 hours post surgery
| Intervention | mg (Mean) |
|---|---|
| Ketorolac 30 mg, IV + TAP Block | 38.4 |
| TAP Block | 38.6 |
| Ketorolac 30 mg | 42.6 |
Opioid Consumption 12 Hours Post Operative
Post operative opioid consumption in the 12 hours that occur post-operatively. (NCT04562597)
Timeframe: 12 hours
| Intervention | IV morphine mg equivalents (Mean) |
|---|---|
| Placebo | 19.4 |
| N-acetylcysteine (NAC) | 15.6 |
Opioid Consumption Every 6 Hours Post Operative
Post operative opioid consumption ry 6 hours post operative. Data are reported as mean (95% CI) or mean difference (95% CI) estimated from a linear mixed model of opioid consumption over time including main effects for treatment group, postoperative time, and the interaction between treatment group and postoperative time and a random subject effect. (NCT04562597)
Timeframe: 6-48 hours
| Intervention | IV morphine mg equivalents (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| 6 hours | 18 hours | 24 hours | 30 hours | 36 hours | 42 | 48 | |
| N-acetylcysteine (NAC) | 12.0 | 19.9 | 24.7 | 27.2 | 29.7 | 33.1 | 34.9 |
| Placebo | 14.6 | 25.0 | 29.6 | 34.0 | 37.9 | 40.9 | 43.3 |
Efficacy of Two Different Liquid Pain Medications: Tramadol vs. Codeine/Acetaminophen During the Post-tonsillectomy Recovery Period.
Average number of post-operative days with pain score >4/10. Pain score assessments were administered once daily by parents using either the Numeric Rating Scale (NRS-11) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 8-15 (von Baeyer et al., 2009) or the Faces Pain Scale-Revised (FPS-R) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 4-10 (Hicks et al., 2001). (NCT01267136)
Timeframe: Efficacy was assessed daily during the 10-day postoperative recovery period.
| Intervention | days (Median) |
|---|---|
| Capital® With Codeine Suspension | 1.5 |
| Tramadol Suspension | 1 |
Number of Participants Reporting Side Effects During the Post-tonsillectomy Recovery Period.
Parent-reported side effects entered in 10-day diary. (NCT01267136)
Timeframe: Side effects will be observed and recorded daily by caregivers for a total of 10 days in the take-home diary.
| Intervention | participants (Number) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Nausea | Vomiting | Fever | Itching | Rash | Sweating | Dizziness | Headache | Constipation | Oversedation | Tonsil bleed | |
| Capital® With Codeine Suspension | 20 | 21 | 11 | 5 | 1 | 9 | 15 | 12 | 21 | 14 | 3 |
| Tramadol Suspension | 20 | 18 | 10 | 12 | 1 | 7 | 17 | 17 | 21 | 8 | 0 |
Reviews
2 reviews available for acetaminophen and Nausea
| Article | Year |
|---|---|
Management of pain and spinal cord compression in patients with advanced cancer. ACP-ASIM End-of-life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine.
Topics: Acetaminophen; Drug Administration Schedule; Humans; Narcotics; Nausea; Neoplasms; Pain; Pain Manage | 1999 |
Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Blood Coagulati | 1986 |
Trials
51 trials available for acetaminophen and Nausea
| Article | Year |
|---|---|
Comparing the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children.
Topics: Acetaminophen; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Double-Blind Method; Female | 2022 |
Efficacy and safety of intravenous paracetamol in management of labour pains in a low resource setting: a randomized clinical trial.
Topics: Acetaminophen; Analgesia, Obstetrical; Analgesics; Analgesics, Opioid; Dizziness; Double-Blind Metho | 2022 |
Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Analgesics, Opioid; Antiemetics; Drug Combinations; Fe | 2019 |
Patient education videos for elective colorectal surgery: results of a randomized controlled trial.
Topics: Acetaminophen; Aged; Analgesia, Epidural; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-St | 2013 |
Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Antiemetics; Double-Blind Method; | 2014 |
Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial.
Topics: Acetaminophen; Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Analgesics, | 2014 |
GSK2374697, a novel albumin-binding domain antibody (AlbudAb), extends systemic exposure of exendin-4: first study in humans--PK/PD and safety.
Topics: Acetaminophen; Adult; Aged; Antibodies; Blood Glucose; Exenatide; Female; Gastric Emptying; Glucagon | 2014 |
A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Arthroplasty, Replace | 2015 |
Randomized, double-blind, placebo-controlled study of the efficacy and safety of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen tablets for acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Delayed-Action Prepa | 2015 |
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action | 2015 |
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action | 2015 |
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action | 2015 |
Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Cross-Over Studies; Delayed-Action | 2015 |
Transdermal Buprenorphine Relieves Neuropathic Pain: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial in Diabetic Peripheral Neuropathic Pain.
Topics: Acetaminophen; Administration, Cutaneous; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2016 |
A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Child | 2010 |
Treatment with acetaminophen/paracetamol or ibuprofen alleviates post-dose symptoms related to intravenous infusion with zoledronic acid 5 mg.
Topics: Acetaminophen; Aged; Arthralgia; Body Temperature; Bone Density Conservation Agents; Diphosphonates; | 2012 |
The analgesic effect of continuous subacromial bupivacaine infusion after arthroscopic shoulder surgery: a randomized controlled trial.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Arthro | 2012 |
Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Dizziness; Double-Blind Method; Drug Admi | 2012 |
Acetaminophen improves analgesia but does not reduce opioid requirement after major spine surgery in children and adolescents.
Topics: Acetaminophen; Administration, Intravenous; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid | 2012 |
Tramadol/acetaminophen combination as add-on therapy in the treatment of patients with ankylosing spondylitis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2013 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Adverse effects of superactivated charcoal administered to healthy volunteers.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Charcoal; Constipation; Drug Overdose; Femal | 2002 |
A double-blind placebo-controlled comparison of tramadol/acetaminophen and tramadol in patients with postoperative dental pain.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Dizziness; Double-Bl | 2004 |
The delay of gastric emptying induced by remifentanil is not influenced by posture.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Area Under Curve; Blood Gas Anal | 2004 |
The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Anaphylaxis; Aspartate Aminotransferases | 2005 |
Long-term tolerability of tramadol LP, a new once-daily formulation, in patients with osteoarthritis or low back pain.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Drug Administration Sche | 2005 |
Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non- | 2005 |
Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dizziness; Female; Humans | 2005 |
Effects of repeated-dose isradipine on the abuse liability of cocaine.
Topics: Acetaminophen; Administration, Oral; Adult; Analysis of Variance; Arrhythmias, Cardiac; Calcium Chan | 2005 |
[Evaluation of postoperative analgesia with continuous iliofascial nerve sheath block after total hip arthroplasty replacement: a pilot study].
Topics: Acetaminophen; Aged; Aged, 80 and over; Amides; Analgesia, Patient-Controlled; Analgesics, Non-Narco | 2007 |
Comparison of oral prednisolone/paracetamol and oral indomethacin/paracetamol combination therapy in the treatment of acute goutlike arthritis: a double-blind, randomized, controlled trial.
Topics: Abdominal Pain; Acetaminophen; Acute Disease; Administration, Oral; Aged; Aged, 80 and over; Analges | 2007 |
Oral naproxen but not oral paracetamol reduces the need for rescue analgesic after adenoidectomy in children.
Topics: Acetaminophen; Adenoidectomy; Administration, Inhalation; Administration, Oral; Analgesics; Anti-Inf | 2007 |
Report of a double-blind crossover study to compare flurbiprofen with paracetamol in the treatment of primary dysmenorrhoea.
Topics: Acetaminophen; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Flurbiprofen; Hu | 1983 |
Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recove | 1995 |
The effect of post-operative diet on recovery in the first twelve hours after tonsillectomy and adenoidectomy.
Topics: Acetaminophen; Adenoidectomy; Adolescent; Beverages; Child; Child Behavior; Child, Preschool; Diet; | 1995 |
Pretreatment regimens for adverse events related to infusion of amphotericin B.
Topics: Acetaminophen; Adrenal Cortex Hormones; Amphotericin B; Diphenhydramine; Fever; Headache; Heparin; H | 1995 |
Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy.
Topics: Acetaminophen; Antiemetics; Child; Child, Preschool; Double-Blind Method; Droperidol; Female; Humans | 1994 |
Effects of acetaminophen on adverse effects of influenza vaccination in health care workers.
Topics: Acetaminophen; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Influenza Vacc | 1993 |
Prophylactic paracetamol for analgesia after vaginal termination of pregnancy.
Topics: Abortion, Induced; Acetaminophen; Ambulatory Surgical Procedures; Analgesia; Analgesics; Anesthesia, | 1993 |
Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy.
Topics: Acetaminophen; Adult; Ambulatory Care; Diclofenac; Double-Blind Method; Female; Fentanyl; Humans; In | 1993 |
The use of ondansetron in the treatment of nausea and vomiting associated with acetaminophen poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antiemetics; Humans; Injections, I | 1996 |
Analgesic efficacy of paracetamol in children using tonsillectomy as a pain model.
Topics: Acetaminophen; Administration, Oral; Adolescent; Ambulatory Surgical Procedures; Analgesics, Non-Nar | 1996 |
Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol.
Topics: Acetaminophen; Administration, Rectal; Analgesia; Analgesics; Anesthesia Recovery Period; Child; Chi | 1997 |
Efficacy of ipecac during the first hour after drug ingestion in human volunteers.
Topics: Acetaminophen; Adult; Area Under Curve; Biological Availability; Chromatography, High Pressure Liqui | 1997 |
Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Analgesia, Patient-Cont | 1998 |
Treatment of severe, disabling migraine attacks in an over-the-counter population of migraine sufferers: results from three randomized, placebo-controlled studies of the combination of acetaminophen, aspirin, and caffeine.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Caffeine; Double-Blind Method; D | 1999 |
Comparison of intravenous patient-controlled analgesia with tramadol versus morphine after microvascular breast reconstruction.
Topics: Acetaminophen; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthes | 2000 |
Double-blind randomized study of tramadol vs. paracetamol in analgesia after day-case tonsillectomy in children.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; | 2000 |
Comparison of a fixed combination of domperidone and paracetamol (Domperamol) with sumatriptan 50 mg in moderate to severe migraine: a randomised UK primary care study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cost-Benefit Analysis; Cross-Over Studies; Domperido | 2000 |
Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen.
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Dyspepsia; Female; Humans; | 1975 |
Feprazone, a new anti-inflammatory agent. Studies of potency and gastrointestinal tolerance.
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Digestive System; Female; F | 1975 |
The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextropropoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Chronic Disease; Codeine; Delayed-Action Preparations | 1992 |
[Effect of medical vagotomy on the CDDP induced nausea and vomiting evaluated by the chemotherapy-vomiting time (CV time)].
Topics: Acetaminophen; Adult; Cisplatin; Female; Humans; Metoclopramide; Middle Aged; Nausea; Ovarian Neopla | 1988 |
Migraine treated with an antihistamine-analgesic combination.
Topics: Acetaminophen; Adolescent; Adult; Clinical Trials as Topic; Codeine; Cyclizine; Ergotamine; Female; | 1973 |
Other Studies
30 other studies available for acetaminophen and Nausea
| Article | Year |
|---|---|
[Unusual cause of a PCT-elevation].
Topics: Abdominal Pain; Acetaminophen; Acetylcysteine; Adult; Diagnosis, Differential; Female; Humans; Nause | 2021 |
Around Manaslu Ultramarathon: Diarrhea Is Still the King.
Topics: Acetaminophen; Acetazolamide; Altitude; Altitude Sickness; Analgesics, Non-Narcotic; Anti-Bacterial | 2017 |
Case 6-2019: A 29-Year-Old Woman with Nausea, Vomiting, and Diarrhea.
Topics: Acetaminophen; Adult; Buprenorphine; Cocaine-Related Disorders; Diagnosis, Differential; Diarrhea; D | 2019 |
Suboptimal pain treatment after craniotomy.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Craniotomy; Female; Humans | 2013 |
Infusion technique of hematopoietic progenitor cells and related adverse events (CME).
Topics: Acetaminophen; Adolescent; Adult; Aged; Blood Preservation; Child; Child, Preschool; Cryopreservatio | 2014 |
[Footballer's migraine instead of concussion].
Topics: Acetaminophen; Adult; Antiemetics; Brain Concussion; Diagnosis, Differential; Humans; Male; Migraine | 2014 |
Association between gastrointestinal manifestations following acetaminophen poisoning and outcome in 291 acetaminophen poisoning patients.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Induced Liver Injury; C | 2010 |
A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Drug Administration Routes; Drug Overdose; Humans; Infus | 2010 |
Spontaneous intracerebral hemorrhage associated with ingestion of isometheptine containing anti-migraine medication.
Topics: Acetaminophen; Adult; Antipyrine; Cerebral Hemorrhage; Chloral Hydrate; Drug Combinations; Emergency | 2011 |
Paracetamol and simvastatin: a potential interaction resulting in hepatotoxicity.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Coronary Artery Bypass; Cytochrome P-450 CYP3A; Drug | 2012 |
[STUDIES OF THE EFFICACY OF A COMBINATION OF A MUSCLE RELAXANT, AN ANALGESIC AND OF PREDNISOLONE IN THE ILLNESS OF RHEUMATIC TYPE DISORDERS].
Topics: Acetaminophen; Analgesics; Drug Therapy; Geriatrics; Heartburn; Humans; Muscle Relaxants, Central; N | 1964 |
Acetadote (intravenous acetylcysteine): adverse effects more significant than with oral acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Antidotes; Drug Interactions; Drug Overdose; Em | 2006 |
[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine].
Topics: Acetaminophen; Anesthetics, Intravenous; Aspirin; Chlorpheniramine; Cholecystectomy, Laparoscopic; D | 2007 |
Effect of migraine attacks on paracetamol absorption.
Topics: Acetaminophen; Adult; Female; Humans; Intestinal Absorption; Kinetics; Middle Aged; Migraine Disorde | 1984 |
[Benoxaprofen in the treatment of spondylosis and spondylarthrosis (author's transl)].
Topics: Acetaminophen; Adult; Benzoxazoles; Drug Evaluation; Female; Humans; Joint Diseases; Male; Middle Ag | 1981 |
A double blind study of metoclopramide in the treatment of migraine attacks.
Topics: Acetaminophen; Adolescent; Adult; Aged; Diazepam; Double-Blind Method; Drug Therapy, Combination; Fe | 1980 |
Ondansetron for treating nausea and vomiting in the poisoned patient.
Topics: Acetaminophen; Adolescent; Charcoal; Colchicine; Drug Overdose; Female; Humans; Nausea; Ondansetron; | 1994 |
Paracetamol poisoning and hepatotoxicity in Chinese--the Prince of Wales Hospital (Hong Kong) experience.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Chi | 1993 |
Supportive care during aldesleukin therapy for patients infected with human immunodeficiency virus.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antiemetics; Female; Fever; HIV Infections; Humans; | 1997 |
Additive analgesia without opioid side effects.
Topics: Acetaminophen; Ambulatory Care; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflam | 2000 |
Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; Area Under Curve; Blood Glucose; Depression | 2001 |
[Acute kidney failure caused by paracetamol poisoning].
Topics: Acetaminophen; Acute Kidney Injury; Adult; Blood Coagulation Tests; Chemical and Drug Induced Liver | 2001 |
Pain control in endodontics.
Topics: Acetaminophen; Analgesics; Aspirin; Cellulitis; Codeine; Dextropropoxyphene; Humans; Nausea; Pain; P | 1979 |
Purging with paracetamol: report of four cases.
Topics: Acetaminophen; Adolescent; Adult; Body Image; Body Weight; Bulimia; Female; Humans; Nausea; Substanc | 1992 |
Is fentanyl effective for postoperative analgesia in day-surgery?
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesia; Anesthesia | 1992 |
Epidural morphine for analgesia after caesarean section: a report of 4880 patients.
Topics: Acetaminophen; Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean S | 1990 |
Epidural morphine for analgesia after caesarean section: a report of 4880 patients.
Topics: Acetaminophen; Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean S | 1990 |
Epidural morphine for analgesia after caesarean section: a report of 4880 patients.
Topics: Acetaminophen; Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean S | 1990 |
Epidural morphine for analgesia after caesarean section: a report of 4880 patients.
Topics: Acetaminophen; Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean S | 1990 |
Treatment of common minor ailments.
Topics: Acetaminophen; Antacids; Antiemetics; Aspirin; Dyspepsia; Female; Heartburn; Histamine H1 Antagonist | 1986 |
Acetaminophen poisoning.
Topics: Acetaminophen; Adolescent; Catalogs, Drug as Topic; Charcoal; Chemical and Drug Induced Liver Injury | 1973 |
Analgesic nephropathy associated with paracetamol.
Topics: Acetaminophen; Codeine; Female; Headache; Humans; Kidney Diseases; Middle Aged; Nausea; Phenacetin; | 1973 |
Migraine--treatment of acute attack.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Antiemetics; Aspirin; Child; Ergotamine; Female; | 1971 |