acetaminophen has been researched along with Myocardial Infarction in 28 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The initiation of sodium-containing acetaminophen was associated with increased risks of CVD and all-cause mortality among individuals with or without hypertension." | 8.12 | Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension. ( Djousse, L; Lei, G; Li, X; Rosenberg, L; Wei, J; Zeng, C; Zhang, Y, 2022) |
| "The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure." | 7.96 | Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020) |
| "Experimental evidence raises the possibility that acetaminophen use could reduce the risk of myocardial infarction (MI)." | 7.72 | A case-control study of acetaminophen use in relation to the risk of first myocardial infarction in men. ( Palmer, JR; Rao, RS; Rosenberg, L, 2003) |
| "The hypothesis that acetaminophen can reduce necrosis during myocardial infarction was tested in male dogs." | 7.72 | Acetaminophen and myocardial infarction in dogs. ( Golfetti, R; Merrill, GF; Rork, TH; Spiler, NM, 2004) |
| "Acetaminophen exposure was a time-dependent variable." | 5.42 | Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. ( Dawson, J; Dominiczak, AF; Fulton, RL; McInnes, GT; Meredith, PA; Morrison, DS; Morton, R; Padmanabhan, S; Touyz, RM; Walters, MR, 2015) |
| "Acetaminophen is a commonly used alternative to nonsteroidal anti-inflammatory drugs, which have recently been demonstrated to increase mortality after acute myocardial infarction (AMI)." | 5.33 | Role of acetaminophen in acute myocardial infarction. ( Gorman, JH; Gorman, RC; Hinmon, R; Jackson, BM; Leshnower, BG; Parish, LM; Plappert, T; Sakamoto, H; Zeeshan, A, 2006) |
| "Acetaminophen is a widely used analgesic, and recent studies have shown that it has some benefits in the ischemic heart." | 5.32 | Acetaminophen and experimental acute myocardial infarction. ( Hale, SL; Kloner, RA, 2004) |
| "To assess the efficacy of cyclooxygenase-2 selective inhibitors (coxibs) in osteoarthritis (OA) and their gastrointestinal, cardiovascular, renovascular, and hepatic side effects compared with traditional nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen." | 4.84 | COX-2 selective inhibitors in the treatment of osteoarthritis. ( Hochberg, M; Laine, L; Rostom, A; White, WB, 2008) |
| "Effervescent formulations of paracetamol containing sodium bicarbonate have been reported to associate with increased blood pressure and a higher risk of cardiovascular diseases and all-cause mortality." | 4.31 | Sodium-based paracetamol: impact on blood pressure, cardiovascular events, and all-cause mortality. ( Canoy, D; Huang, J; Li, Y; Mamouei, M; Nazarzadeh, M; Neal, B; Rahimi, K; Rao, S; Salimi-Khorshidi, G; Schutte, AE; Smith, GD, 2023) |
| "The initiation of sodium-containing acetaminophen was associated with increased risks of CVD and all-cause mortality among individuals with or without hypertension." | 4.12 | Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension. ( Djousse, L; Lei, G; Li, X; Rosenberg, L; Wei, J; Zeng, C; Zhang, Y, 2022) |
| "The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure." | 3.96 | Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020) |
| "Recent controversies on the safety profiles of opioids and paracetamol (acetaminophen) have led to changes in clinical guidance on osteoarthritis (OA) management." | 3.88 | Analgesic Use and Risk for Acute Coronary Events in Patients With Osteoarthritis: A Population-based, Nested Case-control Study. ( Aragón, M; Elorza, JM; Marsal, JR; Morros, R; Pontes, C; Prieto-Alhambra, D, 2018) |
| "Experimental evidence raises the possibility that acetaminophen use could reduce the risk of myocardial infarction (MI)." | 3.72 | A case-control study of acetaminophen use in relation to the risk of first myocardial infarction in men. ( Palmer, JR; Rao, RS; Rosenberg, L, 2003) |
| "The hypothesis that acetaminophen can reduce necrosis during myocardial infarction was tested in male dogs." | 3.72 | Acetaminophen and myocardial infarction in dogs. ( Golfetti, R; Merrill, GF; Rork, TH; Spiler, NM, 2004) |
| " There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis." | 3.65 | Lysozymuria and acute disorders of renal function. ( De Silva, KL; Harrison, JF; Parker, RW, 1973) |
| " A recent systematic review found increased adverse events and mortality at therapeutic dosage." | 1.51 | Acetaminophen Safety: Risk of Mortality and Cardiovascular Events in Nursing Home Residents, a Prospective Study. ( Cantet, C; de Souto Barreto, P; Girard, P; Rolland, Y; Sourdet, S, 2019) |
| "Acetaminophen exposure was a time-dependent variable." | 1.42 | Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. ( Dawson, J; Dominiczak, AF; Fulton, RL; McInnes, GT; Meredith, PA; Morrison, DS; Morton, R; Padmanabhan, S; Touyz, RM; Walters, MR, 2015) |
| "Simvastatin is a substrate of CYP3A4 enzyme." | 1.38 | Paracetamol and simvastatin: a potential interaction resulting in hepatotoxicity. ( Gumbrevičius, G; Stankevičius, E; Sveikata, A; Sveikatienė, R, 2012) |
| "Acetaminophen is a commonly used alternative to nonsteroidal anti-inflammatory drugs, which have recently been demonstrated to increase mortality after acute myocardial infarction (AMI)." | 1.33 | Role of acetaminophen in acute myocardial infarction. ( Gorman, JH; Gorman, RC; Hinmon, R; Jackson, BM; Leshnower, BG; Parish, LM; Plappert, T; Sakamoto, H; Zeeshan, A, 2006) |
| "Acetaminophen is a widely used analgesic, and recent studies have shown that it has some benefits in the ischemic heart." | 1.32 | Acetaminophen and experimental acute myocardial infarction. ( Hale, SL; Kloner, RA, 2004) |
| "Four caffeine-treated rats had histologic evidence of acute myocardial infarction which was not found in any of the other rats." | 1.26 | Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine. ( Johansson, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.29) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 13 (46.43) | 29.6817 |
| 2010's | 5 (17.86) | 24.3611 |
| 2020's | 5 (17.86) | 2.80 |
| Authors | Studies |
|---|---|
| Zeng, C | 1 |
| Rosenberg, L | 2 |
| Li, X | 1 |
| Djousse, L | 1 |
| Wei, J | 1 |
| Lei, G | 1 |
| Zhang, Y | 1 |
| Rao, S | 1 |
| Nazarzadeh, M | 1 |
| Canoy, D | 1 |
| Li, Y | 1 |
| Huang, J | 1 |
| Mamouei, M | 1 |
| Salimi-Khorshidi, G | 1 |
| Schutte, AE | 1 |
| Neal, B | 1 |
| Smith, GD | 1 |
| Rahimi, K | 1 |
| Javaherforooshzadeh, F | 1 |
| Abdalbeygi, H | 1 |
| Janatmakan, F | 1 |
| Gholizadeh, B | 1 |
| Weinstein, RB | 1 |
| Ryan, PB | 1 |
| Berlin, JA | 1 |
| Schuemie, MJ | 1 |
| Swerdel, J | 1 |
| Fife, D | 1 |
| Li, J | 1 |
| Karlsson, MO | 1 |
| Sanhajariya, S | 1 |
| Isbister, GK | 1 |
| Duffull, SB | 1 |
| Pontes, C | 1 |
| Marsal, JR | 1 |
| Elorza, JM | 1 |
| Aragón, M | 1 |
| Prieto-Alhambra, D | 1 |
| Morros, R | 1 |
| Girard, P | 1 |
| Sourdet, S | 1 |
| Cantet, C | 1 |
| de Souto Barreto, P | 1 |
| Rolland, Y | 1 |
| Fulton, RL | 1 |
| Walters, MR | 1 |
| Morton, R | 1 |
| Touyz, RM | 1 |
| Dominiczak, AF | 1 |
| Morrison, DS | 1 |
| Padmanabhan, S | 1 |
| Meredith, PA | 1 |
| McInnes, GT | 1 |
| Dawson, J | 1 |
| Glasser, SP | 1 |
| Khodneva, Y | 1 |
| Solzbach, U | 1 |
| Knöpfle, N | 1 |
| Haas, H | 1 |
| Gumbrevičius, G | 1 |
| Sveikata, A | 1 |
| Sveikatienė, R | 1 |
| Stankevičius, E | 1 |
| Brandt, KD | 1 |
| Rao, RS | 1 |
| Palmer, JR | 1 |
| Dai, W | 1 |
| Kloner, RA | 2 |
| Alcindor, D | 1 |
| Krolikowski, JG | 1 |
| Pagel, PS | 1 |
| Warltier, DC | 1 |
| Kersten, JR | 1 |
| Hale, SL | 1 |
| Merrill, GF | 1 |
| Rork, TH | 1 |
| Spiler, NM | 1 |
| Golfetti, R | 1 |
| Manini, AF | 1 |
| Kabrhel, C | 1 |
| Thomsen, TW | 1 |
| Zhu, YZ | 1 |
| Chong, CL | 1 |
| Chuah, SC | 1 |
| Huang, SH | 1 |
| Nai, HS | 1 |
| Tong, HT | 1 |
| Whiteman, M | 1 |
| Moore, PK | 1 |
| Leshnower, BG | 1 |
| Sakamoto, H | 1 |
| Zeeshan, A | 1 |
| Parish, LM | 1 |
| Hinmon, R | 1 |
| Plappert, T | 1 |
| Jackson, BM | 1 |
| Gorman, JH | 1 |
| Gorman, RC | 1 |
| Kurth, T | 1 |
| Rahme, E | 1 |
| Nedjar, H | 1 |
| Laine, L | 1 |
| White, WB | 1 |
| Rostom, A | 1 |
| Hochberg, M | 1 |
| Johansson, S | 1 |
| Vesterqvist, O | 1 |
| Gréen, K | 1 |
| George, S | 1 |
| Vannozi, Z | 1 |
| Hollister, LE | 1 |
| Harrison, JF | 1 |
| Parker, RW | 1 |
| De Silva, KL | 1 |
2 reviews available for acetaminophen and Myocardial Infarction
| Article | Year |
|---|---|
COX-2 selective inhibitors in the treatment of osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cycl | 2008 |
Effective use of analgesic drugs.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ast | 1976 |
1 trial available for acetaminophen and Myocardial Infarction
| Article | Year |
|---|---|
Comparing the effects of ketorolac and Paracetamol on postoperative pain relief after coronary artery bypass graft surgery. A randomized clinical trial.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Coronary Artery Bypass; Coronary Artery Disease; Doub | 2020 |
25 other studies available for acetaminophen and Myocardial Infarction
| Article | Year |
|---|---|
Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension.
Topics: Acetaminophen; Aged; Cardiovascular Diseases; Humans; Hypertension; Myocardial Infarction; Risk Fact | 2022 |
Sodium-based paracetamol: impact on blood pressure, cardiovascular events, and all-cause mortality.
Topics: Acetaminophen; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cardiovascular Dise | 2023 |
Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Ag | 2020 |
A general model for cell death and biomarker release from injured tissues.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Animals; Aspartate Aminotransfe | 2021 |
Analgesic Use and Risk for Acute Coronary Events in Patients With Osteoarthritis: A Population-based, Nested Case-control Study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Angina, Unstable; Ant | 2018 |
Acetaminophen Safety: Risk of Mortality and Cardiovascular Events in Nursing Home Residents, a Prospective Study.
Topics: Acetaminophen; Aged, 80 and over; Analgesics, Non-Narcotic; Female; France; Humans; Male; Mortality; | 2019 |
Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Chronic Pain; Confounding Factors, Ep | 2015 |
Should acetaminophen be added to the list of anti-inflammatory agents that are associated with cardiovascular events?
Topics: Acetaminophen; Blood Pressure; Chronic Pain; Female; Humans; Hypertension; Male; Myocardial Infarcti | 2015 |
[Myocardial infarction-like electrocardiogram in acute Hantavirus infection. Suspected secondary peri-myocarditis].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antibodies, Viral; Back Pain; Diagnosis, Differentia | 2008 |
Paracetamol and simvastatin: a potential interaction resulting in hepatotoxicity.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Coronary Artery Bypass; Cytochrome P-450 CYP3A; Drug | 2012 |
Key questions concerning paracetamol and NSAIDs for OA.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; I | 2003 |
A case-control study of acetaminophen use in relation to the risk of first myocardial infarction in men.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Aspirin; Humans; Male; Middle Aged; Myocardial Infar | 2003 |
Effects of acetaminophen on myocardial infarct size in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Pressure; Body Temperature; Disease Models, | 2003 |
Cyclooxygenase-2 mediates ischemic, anesthetic, and pharmacologic preconditioning in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Anesthetics, Inhalation; Animals; Aspirin; Celecoxib; C | 2004 |
Acetaminophen and experimental acute myocardial infarction.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Pressure; Coronary Circulation; Coronary Dis | 2004 |
Acetaminophen and myocardial infarction in dogs.
Topics: Acetaminophen; Animals; Cardiotonic Agents; Collateral Circulation; Coronary Circulation; Dogs; Elec | 2004 |
Acute myocardial infarction after over-the-counter use of pseudoephedrine.
Topics: Acetaminophen; Adult; Coronary Vasospasm; Drug Combinations; Ephedrine; Humans; Male; Myocardial Inf | 2005 |
Cardioprotective effects of nitroparacetamol and paracetamol in acute phase of myocardial infarction in experimental rats.
Topics: Acetaminophen; Animals; Capillaries; Cardiotonic Agents; Coronary Vessels; Hemodynamics; Liver; Male | 2006 |
Role of acetaminophen in acute myocardial infarction.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Apoptosis; Body Temperature; Corona | 2006 |
Letter by Kurth regarding article, "Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events".
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg | 2006 |
Risks and benefits of COX-2 inhibitors vs non-selective NSAIDs: does their cardiovascular risk exceed their gastrointestinal benefit? A retrospective cohort study.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 I | 2007 |
Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.
Topics: Acetaminophen; Animals; Antipyrine; Caffeine; Cardiovascular Diseases; Heart; Male; Myocardial Infar | 1981 |
Urinary excretion of 2,3-dinor-thromboxane B2 in man under normal conditions, following drugs and during some pathological conditions.
Topics: Acetaminophen; Adult; Amino Acid Metabolism, Inborn Errors; Aspirin; Circadian Rhythm; Diabetes Mell | 1984 |
Myocardial infarction induced by migraine therapy.
Topics: Acetaminophen; Adult; Antipyrine; Chloral Hydrate; Coronary Vasospasm; Drug Combinations; Female; Hu | 1995 |
Lysozymuria and acute disorders of renal function.
Topics: Acetaminophen; Acute Disease; Aspirin; Electroshock; Glomerulonephritis; Heart Failure; Humans; Hypo | 1973 |