Page last updated: 2024-10-22

acetaminophen and Middle Ear Inflammation

acetaminophen has been researched along with Middle Ear Inflammation in 20 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
"This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM."9.51The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."9.41Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023)
"Two hundred and nineteen children (boys: 56%, girls: 44%) were included in a randomized, double-blind, multicentre (4 centres) controlled trial designed to assess the efficacy and safety of ibuprofen (IBU) in the treatment of 1 to 6 year-old children with otoscopically proven acute otitis media (AOM), either unilateral or bilateral."9.08A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. ( Bertin, L; d'Athis, P; Debregeas, B; Duhamel, JF; Guillot, M; Lasfargues, G; Marsac, A; Maudelonde, C; Olive, G; Pons, G, 1996)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."8.93Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016)
"The possible interference of acetaminophen, combined with antibiotics, in the treatment of acute otitis media (AOM) caused by a penicillin-resistant (minimal inhibitory concentration [MIC], 2 microg/mL), amoxicillin/clavulanic acid- and erythromycin-sensitive pneumococcus was evaluated in a gerbil model."7.72Does acetaminophen interfere in the antibiotic treatment of acute otitis media caused by a penicillin-resistant pneumococcus strain? A gerbil model. ( Aguilar, L; Carcas, A; Cenjor, C; Garcia-Olmos, M; Gimenez, MJ; Parra, A; Ponte, C; Soriano, F, 2003)
"This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM."5.51The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."5.41Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023)
"Acetaminophen alone may not be as effective in reducing pain-related physiological and behavioral changes as acetaminophen plus codeine or ibuprofen plus midazolam during diagnostic tympanocentesis."5.15Pain management in young children undergoing diagnostic tympanocentesis. ( Chandra, A; Colborn, DK; Hoberman, A; Hooper, EG; Kurs-Lasky, M; Reis, EC; Rockette, HE; Shaikh, N, 2011)
"Two hundred and nineteen children (boys: 56%, girls: 44%) were included in a randomized, double-blind, multicentre (4 centres) controlled trial designed to assess the efficacy and safety of ibuprofen (IBU) in the treatment of 1 to 6 year-old children with otoscopically proven acute otitis media (AOM), either unilateral or bilateral."5.08A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. ( Bertin, L; d'Athis, P; Debregeas, B; Duhamel, JF; Guillot, M; Lasfargues, G; Marsac, A; Maudelonde, C; Olive, G; Pons, G, 1996)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."4.93Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016)
"The possible interference of acetaminophen, combined with antibiotics, in the treatment of acute otitis media (AOM) caused by a penicillin-resistant (minimal inhibitory concentration [MIC], 2 microg/mL), amoxicillin/clavulanic acid- and erythromycin-sensitive pneumococcus was evaluated in a gerbil model."3.72Does acetaminophen interfere in the antibiotic treatment of acute otitis media caused by a penicillin-resistant pneumococcus strain? A gerbil model. ( Aguilar, L; Carcas, A; Cenjor, C; Garcia-Olmos, M; Gimenez, MJ; Parra, A; Ponte, C; Soriano, F, 2003)
"232 children aged 3-10 years with acute earache and at least one abnormal eardrum (114 allocated to receive antibiotic, 118 placebo)."2.67Acute red ear in children: controlled trial of non-antibiotic treatment in general practice. ( Bain, J; Burke, P; Dunleavey, J; Robinson, D, 1991)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.00)18.7374
1990's4 (20.00)18.2507
2000's6 (30.00)29.6817
2010's5 (25.00)24.3611
2020's3 (15.00)2.80

Authors

AuthorsStudies
Kara, A1
Büyükcam, A1
Sütçü, M1
Sali, E1
Bozdemir, ŞE1
Kara, M1
İlarslan, EÇ1
Kaya, C1
Karakaşlılar, S1
Sönmez, G1
Kara, SS1
Bedir, T1
Albayrak, E1
Kara, TT1
Çelebi, S1
Öz, FN1
Karbuz, A1
Somer, A1
Alabaz, D1
Tezer, H1
Özdemir, H1
Çiftçi, E1
de Sévaux, JLH1
Damoiseaux, RA2
van de Pol, AC3
Lutje, V1
Hay, AD2
Little, P3
Schilder, AG2
Venekamp, RP3
Kmietowicz, Z1
McHale, B1
Badenhorst, CD1
Low, C1
Blundell, D1
van Uum, RT1
Sjoukes, A2
de Wit, GA1
Schilder, AGM1
Damoiseaux, RAMJ1
Shaikh, N1
Hoberman, A1
Kurs-Lasky, M1
Rockette, HE1
Chandra, A1
Colborn, DK1
Hooper, EG1
Reis, EC1
O'Neill, P4
Ponte, C1
Parra, A1
Cenjor, C1
Garcia-Olmos, M1
Gimenez, MJ1
Aguilar, L1
Carcas, A1
Soriano, F1
Roberts, T2
Bradley Stevenson, C1
Stipon, JP1
Le Bihan, Y1
de Rotalier, P1
Bertin, L1
Pons, G1
d'Athis, P1
Duhamel, JF1
Maudelonde, C1
Lasfargues, G1
Guillot, M1
Marsac, A1
Debregeas, B1
Olive, G1
Gould, C1
Williamson, I1
Moore, M1
Warner, G1
Dunleavey, J2
Murtagh, J1
Burke, P1
Bain, J1
Robinson, D1
Hickish, G1
Clarke, E1
Maw, R1
Howie, VM1
Ploussard, JH1

Reviews

6 reviews available for acetaminophen and Middle Ear Inflammation

ArticleYear
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
    The Cochrane database of systematic reviews, 2023, 08-18, Volume: 8

    Topics: Acetaminophen; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans;

2023
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
    The Cochrane database of systematic reviews, 2016, 12-15, Volume: 12

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Age

2016
Acute otitis media.
    Clinical evidence, 2002, Issue:7

    Topics: Acetaminophen; Acute Disease; Anti-Bacterial Agents; Chewing Gum; Child, Preschool; Female; Humans;

2002
Acute otitis media.
    Clinical evidence, 2002, Issue:8

    Topics: Acetaminophen; Acute Disease; Anti-Bacterial Agents; Chewing Gum; Child, Preschool; Female; Humans;

2002
Acute otitis media in children.
    Clinical evidence, 2005, Issue:13

    Topics: Acetaminophen; Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child;

2005
Otitis media in children (acute).
    Clinical evidence, 2006, Issue:15

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Age

2006

Trials

9 trials available for acetaminophen and Middle Ear Inflammation

ArticleYear
The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media.
    International journal of pediatric otorhinolaryngology, 2022, Volume: 156

    Topics: Acetaminophen; Acute Disease; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Earache; H

2022
Do children undergoing bilateral myringotomy with placement of ventilating tubes benefit from pre-operative analgesia? A double-blinded, randomised, placebo-controlled trial.
    The Journal of laryngology and otology, 2018, Volume: 132, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Double-Blind Method; F

2018
Optimising pain management in children with acute otitis media through a primary care-based multifaceted educational intervention: study protocol for a cluster randomised controlled trial.
    Trials, 2018, Sep-17, Volume: 19, Issue:1

    Topics: Acetaminophen; Acute Pain; Age Factors; Analgesics, Non-Narcotic; Child; Child, Preschool; Cost-Bene

2018
Pain management in young children undergoing diagnostic tympanocentesis.
    Clinical pediatrics, 2011, Volume: 50, Issue:3

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Biopsy, Fine-Needle; Chi

2011
[Evaluation of the analgesic effect of UP 341-01 in patients presenting with acute pain in ORL].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Oct-27, Volume: 59, Issue:39

    Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Clinical Trials as Topic; Female; Humans; Injection

1983
A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children.
    Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chi

1996
Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media.
    BMJ (Clinical research ed.), 2001, Feb-10, Volume: 322, Issue:7282

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Bias; Child; Child, P

2001
Acute red ear in children: controlled trial of non-antibiotic treatment in general practice.
    BMJ (Clinical research ed.), 1991, Sep-07, Volume: 303, Issue:6802

    Topics: Acetaminophen; Acoustic Impedance Tests; Acute Disease; Amoxicillin; Child; Child, Preschool; Crying

1991
Efficacy of fixed combination antibiotics versus separate components in otitis media. Effectiveness of erythromycin estrolate, triple sulfonamide, ampicillin, erythromycin estolate- triple sulfonamide, and placebo in 280 patients with acute otitis media u
    Clinical pediatrics, 1972, Volume: 11, Issue:4

    Topics: Acetaminophen; Acute Disease; Ampicillin; Child, Preschool; Chlorpheniramine; Drug Combinations; Ery

1972

Other Studies

5 other studies available for acetaminophen and Middle Ear Inflammation

ArticleYear
Drugs for acute otitis media in children.
    The Medical letter on drugs and therapeutics, 2022, Feb-07, Volume: 64, Issue:1643

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Agent

2022
Most cases of otitis media should not be treated with antibiotics, says NICE.
    BMJ (Clinical research ed.), 2017, 09-21, Volume: 358

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroi

2017
Does acetaminophen interfere in the antibiotic treatment of acute otitis media caused by a penicillin-resistant pneumococcus strain? A gerbil model.
    Pediatric research, 2003, Volume: 54, Issue:6

    Topics: Acetaminophen; Acute Disease; Amoxicillin; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents;

2003
The painful ear.
    Australian family physician, 1991, Volume: 20, Issue:12

    Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Adult; Amoxicillin; Anti-Bacterial Agents; Ch

1991
Otitis media.
    The Practitioner, 1990, Jun-22, Volume: 234, Issue:1491

    Topics: Acetaminophen; Adenoidectomy; Amoxicillin; Child, Preschool; Humans; Male; Middle Ear Ventilation; O

1990