acetaminophen has been researched along with Methemoglobinemia in 37 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of early coma, metabolic acidosis and methemoglobinemia after substantial acetaminophen toxicity in the absence of hepatic failure." | 7.79 | Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity. ( Boucher, P; Dias, VC; Kanji, HD; Mithani, S; Yarema, MC, 2013) |
| " Topical anesthesia with benzocaine or lidocaine occasionally causes methemoglobinemia, an uncommon but potentially fatal disorder where the blood has a reduced ability to transport oxygen." | 3.85 | Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine. ( Boyne, M; Colatsky, T; Hartman, N; Mans, D; Mao, J; Patel, V; Zhou, H, 2017) |
| "Methemoglobinemia (MetHb) after exposure to benzocaine (BZC) has been reported for more than 50 years, however the pathophysiologic mechanism has not been previously established." | 3.80 | Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure. ( Casavant, MJ; Gerona, RR; Ho, RY; Russell, JL; Spiller, HA, 2014) |
| " Methemoglobinemia, facial edema, and hemoglobinuria responded to treatment with intravenous fluids, N-acetylcysteine, ascorbic acid, and sodium bicarbonate." | 3.72 | Acetaminophen toxicosis in a Dalmatian. ( MacNaughton, SM, 2003) |
| "To investigate the effects of the association of inhaled nitric oxide (iNO) and oxidant drugs (acetaminophen, phytomenadione, and EMLA cream) on methemoglobinemia during the neonatal period." | 3.70 | Combined effects of inhaled nitric oxide (iNO) and oxidant agents on the production of methemoglobinemia in newborn piglets. ( Klosowski, S; Kongolo, G; Lequien, P; Martin-Ponthieu, A; Rakza, T; Riou, Y; Storme, L; Zerimech, F, 2000) |
| "Acetaminophen intoxication has become the leading cause of acute liver failure (ALF) in Europe and the USA." | 1.72 | Early biomarkers predicting outcome in a porcine model of acetaminophen intoxication: A pilot study. ( Königsrainer, A; Lischner, U; Morgalla, M; Peter, A; Schenk, M; Thiel, C; Thiel, K, 2022) |
| "Methemoglobinemia is a potentially fatal condition, mainly acquired after intoxication by certain drugs." | 1.46 | Methemoglobinemia After Paracetamol Ingestion: A Case Report. ( Lopes, D; Queirós, C; Salvador, P; Ventura, A, 2017) |
| "Buthionine sulfoximine is used to inactivate glutathione synthesis, and small increments of acetaminophen are given intravenously to maintain the plasma level at approximately 200 micrograms/ml for 20 hr." | 1.28 | An improved model of acetaminophen-induced fulminant hepatic failure in dogs. ( Chong, MG; He, DE; Kelly, JH; Koussayer, T; Shang, TA; Sussman, NL; Whisennand, HH, 1992) |
| " In cats, APAP-sulfate was the major metabolite in urine at all three dosage levels, but the fraction of the total urinary metabolites represented by APAP-sulfate decreased as the dosage increased." | 1.27 | The toxicity and biotransformation of single doses of acetaminophen in dogs and cats. ( Leipold, HW; Nash, SL; Oehme, FW; Savides, MC, 1984) |
| " A close correlation between administered dosage of the drug, acetaminophen blood levels and methemoglobinemia was found." | 1.27 | [Paracetamol poisoning in a swine model]. ( Artwohl, J; Dziwisch, L; Henne-Bruns, D; Kremer, B, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (43.24) | 18.7374 |
| 1990's | 6 (16.22) | 18.2507 |
| 2000's | 5 (13.51) | 29.6817 |
| 2010's | 6 (16.22) | 24.3611 |
| 2020's | 4 (10.81) | 2.80 |
| Authors | Studies |
|---|---|
| Thiel, C | 1 |
| Lischner, U | 1 |
| Morgalla, M | 1 |
| Peter, A | 1 |
| Schenk, M | 1 |
| Königsrainer, A | 1 |
| Thiel, K | 1 |
| Rianprakaisang, T | 2 |
| Blumenberg, A | 2 |
| Hendrickson, RG | 2 |
| Sahu, KK | 1 |
| Mishra, AK | 1 |
| Lal, A | 1 |
| George, SV | 1 |
| Pruthi, S | 1 |
| Shah, S | 1 |
| Gambhir, HS | 1 |
| Queirós, C | 1 |
| Salvador, P | 1 |
| Ventura, A | 1 |
| Lopes, D | 1 |
| Kanji, HD | 1 |
| Mithani, S | 1 |
| Boucher, P | 1 |
| Dias, VC | 1 |
| Yarema, MC | 1 |
| Spiller, HA | 1 |
| Russell, JL | 1 |
| Casavant, MJ | 1 |
| Ho, RY | 1 |
| Gerona, RR | 1 |
| Hartman, N | 1 |
| Zhou, H | 1 |
| Mao, J | 1 |
| Mans, D | 1 |
| Boyne, M | 1 |
| Patel, V | 1 |
| Colatsky, T | 1 |
| McConkey, SE | 1 |
| Grant, DM | 1 |
| Cribb, AE | 1 |
| Avizeh, R | 1 |
| Najafzadeh, H | 1 |
| Razijalali, M | 1 |
| Shirali, S | 1 |
| MacNaughton, SM | 1 |
| Carstairs, SD | 1 |
| Tanen, DA | 1 |
| Nash, SL | 2 |
| Oehme, FW | 2 |
| Rabinovitz, M | 1 |
| Garty, M | 1 |
| Rosenfeld, JB | 1 |
| Savides, MC | 1 |
| Leipold, HW | 1 |
| Cohen, SD | 1 |
| Schlesinger, DP | 1 |
| Dunn, RJ | 1 |
| Lu, HC | 1 |
| Shih, RD | 1 |
| Marcus, S | 1 |
| Ruck, B | 1 |
| Jennis, T | 1 |
| Riou, Y | 1 |
| Storme, L | 1 |
| Klosowski, S | 1 |
| Rakza, T | 1 |
| Kongolo, G | 1 |
| Zerimech, F | 1 |
| Martin-Ponthieu, A | 1 |
| Lequien, P | 1 |
| Kobayashi, T | 1 |
| Kawabata, M | 1 |
| Tanaka, S | 1 |
| Maehara, M | 1 |
| Mishima, A | 1 |
| Murase, T | 1 |
| Margetts, G | 1 |
| Gazzard, BG | 1 |
| Hughes, RD | 1 |
| Mellon, PJ | 1 |
| Portmann, B | 1 |
| Williams, R | 1 |
| Kelly, JH | 1 |
| Koussayer, T | 1 |
| He, DE | 1 |
| Chong, MG | 1 |
| Shang, TA | 1 |
| Whisennand, HH | 1 |
| Sussman, NL | 1 |
| Udosen, EO | 2 |
| Ebong, PE | 2 |
| Weiss, DJ | 1 |
| McClay, CB | 1 |
| Christopher, MM | 1 |
| Murphy, M | 1 |
| Perman, V | 1 |
| Ekanemessang, UM | 1 |
| Mofenson, HC | 1 |
| Caraccio, TR | 1 |
| Hillebrand, G | 1 |
| Mittermüller, J | 1 |
| Henne-Bruns, D | 1 |
| Artwohl, J | 1 |
| Dziwisch, L | 1 |
| Kremer, B | 1 |
| Sutton, E | 1 |
| Soyka, LF | 1 |
| Leyland, A | 1 |
| Peters, G | 1 |
| Baechtold-Fowler, N | 1 |
| Bonjour, JP | 1 |
| Chométy-Diézi, F | 1 |
| Filloux, B | 1 |
| Guidoux, R | 1 |
| Guignard, JP | 1 |
| Peters-Haefeli, L | 1 |
| Roch-Ramel, F | 1 |
| Schelling, JL | 1 |
| Hedinger, C | 1 |
| Weber, E | 1 |
| Azen, EA | 1 |
| Bryan, GT | 1 |
| Shahidi, NT | 1 |
| Rossi, EC | 1 |
| Clatanoff, DV | 1 |
| MacLean, D | 1 |
| Robertson, PG | 1 |
| Bain, S | 1 |
| Welch, RM | 1 |
| Conney, AH | 1 |
| Burns, JJ | 1 |
2 reviews available for acetaminophen and Methemoglobinemia
| Article | Year |
|---|---|
A review of acetaminophen's effect on methemoglobin, glutathione, and some related enzymes.
Topics: Acetaminophen; Animals; Cat Diseases; Cats; Cytochrome-B(5) Reductase; Dog Diseases; Dogs; Glutathio | 1984 |
How safe is acetaminophen? Some practical cautions with this widely used agent.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Chemical Phenomena; Chemistry; Child; Drug Synergism; F | 1973 |
1 trial available for acetaminophen and Methemoglobinemia
| Article | Year |
|---|---|
Evaluation of prophylactic and therapeutic effects of silymarin and N-acetylcysteine in acetaminophen-induced hepatotoxicity in cats.
Topics: Acetaminophen; Acetylcysteine; Animals; Bilirubin; Cat Diseases; Cats; Chemical and Drug Induced Liv | 2010 |
34 other studies available for acetaminophen and Methemoglobinemia
| Article | Year |
|---|---|
Early biomarkers predicting outcome in a porcine model of acetaminophen intoxication: A pilot study.
Topics: Acetaminophen; Albumins; Animals; Biomarkers; Lactates; Liver Failure, Acute; Methemoglobinemia; Pil | 2022 |
Methemoglobinemia associated with massive acetaminophen ingestion: a case series.
Topics: Acetaminophen; Drug Overdose; Fatal Outcome; Female; Humans; Male; Methemoglobin; Methemoglobinemia; | 2020 |
Acetaminophen induced methemoglobinemia.
Topics: Acetaminophen; Eating; Humans; Methemoglobin; Methemoglobinemia | 2020 |
Acetaminophen-associated methemoglobinemia.
Topics: Acetaminophen; Eating; Humans; Methemoglobin; Methemoglobinemia | 2020 |
Laundry Blues: a case of methemoglobinemia with laundry detergent and Tylenol ingestion.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Bipolar Disorder; Brain Diseases; Detergent | 2017 |
Methemoglobinemia After Paracetamol Ingestion: A Case Report.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Female; Humans; Methemoglobinemia | 2017 |
Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity.
Topics: Acetaminophen; Acidosis; Aged; Analgesics, Non-Narcotic; Coma; Female; Humans; Methemoglobinemia | 2013 |
Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure.
Topics: 4-Aminobenzoic Acid; Acetaminophen; Administration, Topical; Benzocaine; Bupivacaine; Child; Cyanosi | 2014 |
Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine.
Topics: Acetaminophen; Anesthetics, Local; Benzocaine; Humans; Lidocaine; Methemoglobin; Methemoglobinemia | 2017 |
The role of para-aminophenol in acetaminophen-induced methemoglobinemia in dogs and cats.
Topics: Acetaminophen; Acetyltransferases; Aminophenols; Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Do | 2009 |
Acetaminophen toxicosis in a Dalmatian.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Ascorbic Acid; Dog Diseases; Dogs; | 2003 |
Case studies in pediatric toxicology.
Topics: Acetaminophen; Antidotes; Antivenins; Charcoal; Child; Child, Preschool; Crotalid Venoms; Drug Overd | 2005 |
[Rare side effects following paracetamol poisoning].
Topics: Acetaminophen; Acidosis; Adolescent; Chemical and Drug Induced Liver Injury; Female; Humans; Methemo | 1984 |
The toxicity and biotransformation of single doses of acetaminophen in dogs and cats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biotransformation; Cats; Dogs; Dose-Response Relations | 1984 |
Mechanisms of toxicological interactions involving organophosphate insecticides.
Topics: Acetaminophen; Acetanilides; Anesthetics; Animals; Drug Interactions; Esterases; Esters; Fenitrothio | 1984 |
Methemoglobinemia and anemia in a dog with acetaminophen toxicity.
Topics: Acetaminophen; Anemia; Animals; Dog Diseases; Dogs; Male; Methemoglobinemia | 1995 |
Massive sulfasalazine and paracetamol ingestion causing acidosis, hyperglycemia, coagulopathy, and methemoglobinemia.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Acute Disease; Adult; Anti-Inflammatory Agents; Blo | 1998 |
Pseudomethemoglobinemia: a case report and review of sulfhemoglobinemia.
Topics: Acetaminophen; Adolescent; Cimetidine; Diagnosis, Differential; Female; Humans; Ibuprofen; Methemogl | 1998 |
Combined effects of inhaled nitric oxide (iNO) and oxidant agents on the production of methemoglobinemia in newborn piglets.
Topics: Acetaminophen; Administration, Inhalation; Animals; Animals, Newborn; Drug Evaluation, Preclinical; | 2000 |
Methemoglobinemia induced by combined use of sodium nitrate and acetoaminophen.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthritis, Rheumatoid; Diabetes Mellitus, Type 2; Dru | 2000 |
Phenacetin and paracetamol.
Topics: Acetaminophen; Anemia, Hemolytic; Central Nervous System; Chemical Phenomena; Chemistry; Humans; Kid | 1976 |
A dog model of fulminant hepatic failure produced by paracetamol administration.
Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Disease Models | 1975 |
An improved model of acetaminophen-induced fulminant hepatic failure in dogs.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biopsy; Blood Glucose; Buthionine Sulfoximine; Chemica | 1992 |
The effect of prolonged exposure of rats to sub-lethal dose of acetaminophen.
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Bilirubin; Drug Evaluation, Preclinical; Liver Functio | 1991 |
Effects of propylene glycol-containing diets on acetaminophen-induced methemoglobinemia in cats.
Topics: Acetaminophen; Animal Feed; Animals; Cat Diseases; Cats; Erythrocyte Count; Erythrocytes; Heinz Bodi | 1990 |
Hepatoxicity evaluation in rats given a single overdose of Acetaminophen (Paracetamol).
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Liv | 1989 |
Toxidromes.
Topics: Acetaminophen; Alkalies; Amphetamines; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Carbo | 1985 |
[Hemolysis, methemoglobinemia and renal failure in a 30-year-old patient].
Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics; Anemia, Hemolytic; Female; Humans; Kidney; Me | 1988 |
[Paracetamol poisoning in a swine model].
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotr | 1988 |
Probable paracetamol toxicity in a cat.
Topics: Acetaminophen; Animals; Cat Diseases; Cats; Chloramphenicol; Conjunctivitis; Edema; Kidney; Liver; L | 1974 |
General and renal toxicity of phenacetin, paracetamol and some anti-mitotic agents in the rat.
Topics: Acetaminophen; Anemia, Macrocytic; Anilides; Animals; Blood; Blood Glucose; Body Weight; Caffeine; D | 1972 |
Obscure hemolytic anemia due to analgesic abuse. Does enterogenous cyanosis exist?
Topics: Acetaminophen; Analgesics; Anemia, Hemolytic; Cyanosis; Female; Glucuronates; Humans; Methemoglobine | 1970 |
Methaemoglobinaemia and paracetamol.
Topics: Acetaminophen; Adult; Female; Humans; Methemoglobinemia; Postpartum Period; Pregnancy | 1968 |
The metabolism of acetophenetidin and N-acetyl-p-aminophenol in the cat.
Topics: Acetaminophen; Animals; Cats; Chromatography; Dogs; Glucuronates; Liver; Male; Methemoglobinemia; Me | 1966 |