acetaminophen has been researched along with Metabolic Acidosis in 82 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "BACKGROUND Chronic acetaminophen toxicity has been known to cause an anion gap metabolic acidosis (AGMA) due to accumulation of 5-oxoproline metabolites." | 9.22 | Severe Anion Gap Metabolic Acidosis Resulting from Combined Chronic Acetaminophen Toxicity and Starvation Ketosis: A Case Report and Literature Review. ( Kalinoski, T, 2022) |
| "Although acetaminophen is commonly used in pregnancy, it can deplete glutathione concentrations and cause accumulation of 5-oxoproline, with subsequent metabolic acidosis." | 8.02 | Malnourishment-Associated Acetaminophen Toxicity in Pregnancy. ( Dom, AM; Olson-Chen, C; Royzer, R, 2021) |
| " As the patient was on long-term dicloxacillin for infective endocarditis prophylaxis and regular paracetamol, pyroglutamic acidosis (PGA) (5-oxoproline acidosis) was considered." | 7.96 | Acquired pyroglutamic acidosis due to long-term dicloxacillin and paracetamol use. ( Almuwais, A; Gibbons, H; Zand Irani, A, 2020) |
| "Pyroglutamic acid, an intermediate in glutathione metabolism, can lead to elevated anion gap metabolic acidosis as rare complication of acetaminophen therapy in adults." | 7.88 | Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen. ( Alhourani, HM; George, LK; Kumar, A; Sarwar, T; Wall, BM, 2018) |
| " Metabolic acidosis due to accumulation of l-5-oxoproline is a rare, poorly understood, disorder associated with acetaminophen treatment in malnourished patients with chronic morbidity." | 7.85 | The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis? ( Anderson, ME; Ingle, BL; Jackson, JM; Mills, GA; Moss, CL; Sharrod-Cole, H; Skipp, PJ; Walker, V, 2017) |
| "A patient was identified with severe metabolic acidosis, a high anion gap and 5-oxoproline accumulation, probably caused by the simultaneous use of paracetamol (acetaminophen) and flucloxacillin." | 7.85 | Metabolic acidosis caused by concomitant use of paracetamol (acetaminophen) and flucloxacillin? A case report and a retrospective study. ( Berbee, JK; Fischer, JC; Kemper, EM; Krediet, CTP; Lammers, LA, 2017) |
| "We present a case of early coma, metabolic acidosis and methemoglobinemia after substantial acetaminophen toxicity in the absence of hepatic failure." | 7.79 | Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity. ( Boucher, P; Dias, VC; Kanji, HD; Mithani, S; Yarema, MC, 2013) |
| "The case we present manifested an anion gap (AG) metabolic acidosis due to a chronic intoxication: acetaminophen (APAP) overuse over a period of weeks." | 7.78 | 5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use. ( Armenian, P; Blanc, PD; Gerona, RR; Mookherjee, S; Wu, AH, 2012) |
| "Metabolic acidosis after acute acetaminophen overdose is typically attributed to either transient lactic acidosis without evidence of hepatic injury or hepatic failure." | 7.76 | 5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose. ( Bechtel, LK; Charlton, NP; Holstege, CP; Lawrence, DT, 2010) |
| "We report the case of a 35-year-old woman who presented with acute pancreatitis and severe metabolic acidosis after overdosing on a drug containing acetaminophen." | 7.75 | Acetaminophen-induced acute pancreatitis. A case report. ( Igarashi, H; Ito, T; Oono, T; Sakai, H; Takayanagi, R; Yoshinaga, M, 2009) |
| "Severe acetaminophen overdoses can independently cause metabolic acidosis and coma in the absence of hepatotoxicity." | 7.70 | Metabolic acidosis and coma following a severe acetaminophen overdose. ( Jones, G; Koulouris, Z; Tierney, MG, 1999) |
| "Metabolic acidosis and coma may develop in patients who experience severe hepatic injury after acetaminophen poisoning." | 7.70 | Early metabolic acidosis and coma after acetaminophen ingestion. ( Blanc, P; Roth, B; Woo, O, 1999) |
| " No clear dose-response relationship existed between the quantity of paracetamol ingested and the observed concentrations of 5-oxoproline." | 6.49 | What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure? ( Liss, DB; Mullins, ME; Paden, MS; Schwarz, ES, 2013) |
| " Chronic intake of sub-lethal doses (i." | 5.48 | [High anion gap metabolic acidosis (pyroglutamic acidosis) induced by chronic acetaminophen use]. ( Canivet, JL; Damas, P; Mistretta, V; Noirot, I; Tchougang Nono, J, 2018) |
| "The treatment with acetaminophen must be interrupted and acetylcysteine should be administered." | 5.48 | [Metabolic Acidosis under Acetaminophen Intake - an Unordinary Side Effect]. ( Böttcher, A; Hitzing, S; Laube, M, 2018) |
| "5-oxoproline acidosis is an uncommon cause of high anion gap metabolic acidosis; however, it is likely that it is under-diagnosed as awareness of the condition remains low and testing can only be performed at specialized laboratories." | 5.40 | Acetaminophen-induced anion gap metabolic acidosis secondary to 5-oxoproline: a case report. ( Abkur, TM; Ali, M; Casserly, L; Mohammed, W, 2014) |
| "Acetaminophen overdose is a well known cause of liver function disorder and even hepatic failure." | 5.36 | [Severe metabolic acidosis as a result of 5-oxoproline in acetaminophen use]. ( Holman, M; ter Maaten, JC, 2010) |
| " The development of type B lactic acidosis with hypoglycemia might have been caused by a deficit in gluconeogenesis secondary to severe hepatic failure and/or a toxic metabolite of acetaminophen." | 5.27 | Anion gap acidosis with hypoglycemia in acetaminophen toxicity. ( Schnurr, LP; Zabrodski, RM, 1984) |
| "BACKGROUND Chronic acetaminophen toxicity has been known to cause an anion gap metabolic acidosis (AGMA) due to accumulation of 5-oxoproline metabolites." | 5.22 | Severe Anion Gap Metabolic Acidosis Resulting from Combined Chronic Acetaminophen Toxicity and Starvation Ketosis: A Case Report and Literature Review. ( Kalinoski, T, 2022) |
| "The acquired form of 5-oxoproline (pyroglutamic acid) metabolic acidosis was first described in 1989 and its relationship to chronic acetaminophen ingestion was proposed the next year." | 4.90 | Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle. ( Emmett, M, 2014) |
| "Although acetaminophen is commonly used in pregnancy, it can deplete glutathione concentrations and cause accumulation of 5-oxoproline, with subsequent metabolic acidosis." | 4.02 | Malnourishment-Associated Acetaminophen Toxicity in Pregnancy. ( Dom, AM; Olson-Chen, C; Royzer, R, 2021) |
| " As the patient was on long-term dicloxacillin for infective endocarditis prophylaxis and regular paracetamol, pyroglutamic acidosis (PGA) (5-oxoproline acidosis) was considered." | 3.96 | Acquired pyroglutamic acidosis due to long-term dicloxacillin and paracetamol use. ( Almuwais, A; Gibbons, H; Zand Irani, A, 2020) |
| "Pyroglutamic acid, an intermediate in glutathione metabolism, can lead to elevated anion gap metabolic acidosis as rare complication of acetaminophen therapy in adults." | 3.88 | Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen. ( Alhourani, HM; George, LK; Kumar, A; Sarwar, T; Wall, BM, 2018) |
| " Metabolic acidosis due to accumulation of l-5-oxoproline is a rare, poorly understood, disorder associated with acetaminophen treatment in malnourished patients with chronic morbidity." | 3.85 | The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis? ( Anderson, ME; Ingle, BL; Jackson, JM; Mills, GA; Moss, CL; Sharrod-Cole, H; Skipp, PJ; Walker, V, 2017) |
| "A patient was identified with severe metabolic acidosis, a high anion gap and 5-oxoproline accumulation, probably caused by the simultaneous use of paracetamol (acetaminophen) and flucloxacillin." | 3.85 | Metabolic acidosis caused by concomitant use of paracetamol (acetaminophen) and flucloxacillin? A case report and a retrospective study. ( Berbee, JK; Fischer, JC; Kemper, EM; Krediet, CTP; Lammers, LA, 2017) |
| "High anion gap metabolic acidosis due to pyroglutamic acid (5-oxoproline) is a rare complication of acetaminophen treatment (which depletes glutathione stores) and is often associated with clinically moderate to severe encephalopathy." | 3.80 | Pyroglutamic acid-induced metabolic acidosis: a case report. ( Dive, A; Galanti, L; Luyasu, S; Wamelink, MM, 2014) |
| "The case we present manifested an anion gap (AG) metabolic acidosis due to a chronic intoxication: acetaminophen (APAP) overuse over a period of weeks." | 3.78 | 5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use. ( Armenian, P; Blanc, PD; Gerona, RR; Mookherjee, S; Wu, AH, 2012) |
| "Metabolic acidosis after acute acetaminophen overdose is typically attributed to either transient lactic acidosis without evidence of hepatic injury or hepatic failure." | 3.76 | 5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose. ( Bechtel, LK; Charlton, NP; Holstege, CP; Lawrence, DT, 2010) |
| "We report the case of a 35-year-old woman who presented with acute pancreatitis and severe metabolic acidosis after overdosing on a drug containing acetaminophen." | 3.75 | Acetaminophen-induced acute pancreatitis. A case report. ( Igarashi, H; Ito, T; Oono, T; Sakai, H; Takayanagi, R; Yoshinaga, M, 2009) |
| " Laboratory evaluation revealed a high anion gap metabolic acidosis and modestly elevated acetaminophen level." | 3.74 | Profound metabolic acidosis and oxoprolinuria in an adult. ( Cantor, R; Carmel, PM; Hodgman, MJ; Holland, MG; Horn, JF; Marraffa, JM; Stork, CM, 2007) |
| "Metabolic acidosis and coma may develop in patients who experience severe hepatic injury after acetaminophen poisoning." | 3.70 | Early metabolic acidosis and coma after acetaminophen ingestion. ( Blanc, P; Roth, B; Woo, O, 1999) |
| " A variety of conditions preceded the onset of acidosis, and all had taken acetaminophen (paracetamol), although in therapeutic amounts in most subjects." | 3.70 | Transient 5-oxoprolinuria and high anion gap metabolic acidosis: clinical and biochemical findings in eleven subjects. ( Hauser, S; Pitt, JJ, 1998) |
| "Severe acetaminophen overdoses can independently cause metabolic acidosis and coma in the absence of hepatotoxicity." | 3.70 | Metabolic acidosis and coma following a severe acetaminophen overdose. ( Jones, G; Koulouris, Z; Tierney, MG, 1999) |
| " Monensin potentiated the cell killing, and extracellular acidosis prevented it." | 3.68 | The killing of cultured hepatocytes by N-acetyl-p-benzoquinone imine (NAPQI) as a model of the cytotoxicity of acetaminophen. ( Farber, JL; Harman, AW; Kyle, ME; Serroni, A, 1991) |
| " No clear dose-response relationship existed between the quantity of paracetamol ingested and the observed concentrations of 5-oxoproline." | 2.49 | What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure? ( Liss, DB; Mullins, ME; Paden, MS; Schwarz, ES, 2013) |
| " This diagnosis was confirmed by an organic acid dosage in the urine." | 1.72 | [A case of pyroglutamic metabolic acidosis after cotreatment by flucloxacillin and paracetamol]. ( Desgranges, A; Hu, K; Monney Chaubert, C, 2022) |
| "The treatment with acetaminophen must be interrupted and acetylcysteine should be administered." | 1.48 | [Metabolic Acidosis under Acetaminophen Intake - an Unordinary Side Effect]. ( Böttcher, A; Hitzing, S; Laube, M, 2018) |
| "Subsequent testing following treatment of the sepsis revealed no ongoing 5-oxoprolinuria." | 1.42 | Transient 5-oxoprolinuria: unusually high anion gap acidosis in an infant. ( Hulley, SL; Manning, N; Olpin, S; Perring, J; Yap, S, 2015) |
| "5-oxoproline acidosis is an uncommon cause of high anion gap metabolic acidosis; however, it is likely that it is under-diagnosed as awareness of the condition remains low and testing can only be performed at specialized laboratories." | 1.40 | Acetaminophen-induced anion gap metabolic acidosis secondary to 5-oxoproline: a case report. ( Abkur, TM; Ali, M; Casserly, L; Mohammed, W, 2014) |
| "Irreversible acute liver failure, defined as rise in prothrombin time >3 times normal, occurred 19." | 1.39 | A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival. ( Alibhai, H; Baker, LA; Chang, YM; Davies, NA; Jalan, R; L Priestnall, S; Leckie, PJ; Lee, KC; Mookerjee, RP; Palacios Jimenez, C; Stanzani, G, 2013) |
| "Acetaminophen overdose is a well known cause of liver function disorder and even hepatic failure." | 1.36 | [Severe metabolic acidosis as a result of 5-oxoproline in acetaminophen use]. ( Holman, M; ter Maaten, JC, 2010) |
| " The development of type B lactic acidosis with hypoglycemia might have been caused by a deficit in gluconeogenesis secondary to severe hepatic failure and/or a toxic metabolite of acetaminophen." | 1.27 | Anion gap acidosis with hypoglycemia in acetaminophen toxicity. ( Schnurr, LP; Zabrodski, RM, 1984) |
| "A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presented." | 1.27 | Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure. ( Fassett, R; Kritharides, L; Singh, B, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (12.20) | 18.7374 |
| 1990's | 6 (7.32) | 18.2507 |
| 2000's | 14 (17.07) | 29.6817 |
| 2010's | 38 (46.34) | 24.3611 |
| 2020's | 14 (17.07) | 2.80 |
| Authors | Studies |
|---|---|
| Crisp, T | 1 |
| Sizeland, P | 1 |
| Du Toit, S | 1 |
| Chan, LW | 1 |
| Lasse, A | 1 |
| Deveaux, M | 1 |
| Beaudeux, JL | 1 |
| Raphalen, JH | 1 |
| Baud, FJ | 1 |
| Houzé, P | 1 |
| Elsayed, S | 1 |
| Gohar, A | 1 |
| Omar, M | 1 |
| Kalinoski, T | 1 |
| van Montfort, P | 1 |
| Helmich, F | 1 |
| Mostard, G | 1 |
| van Twist, D | 1 |
| Desgranges, A | 1 |
| Hu, K | 1 |
| Monney Chaubert, C | 1 |
| Hoshitsuki, K | 1 |
| Molinelli, AR | 1 |
| Inaba, H | 1 |
| Rubnitz, JE | 1 |
| Barker, PJ | 1 |
| Zand Irani, A | 2 |
| Almuwais, A | 1 |
| Gibbons, H | 2 |
| Mullins, ME | 2 |
| Yeager, LH | 1 |
| Freeman, WE | 1 |
| Trevor-Jones, E | 2 |
| Hughes, LT | 1 |
| Robson, R | 1 |
| Bromley, A | 1 |
| Stewart, GW | 2 |
| Borchert, G | 1 |
| Craven, B | 1 |
| Dom, AM | 1 |
| Royzer, R | 1 |
| Olson-Chen, C | 1 |
| Morreale, A | 1 |
| Canivet, JL | 2 |
| Charlier, C | 1 |
| Misset, B | 1 |
| Berbee, JK | 1 |
| Lammers, LA | 1 |
| Krediet, CTP | 1 |
| Fischer, JC | 1 |
| Kemper, EM | 1 |
| Hložek, T | 1 |
| Křížek, T | 1 |
| Tůma, P | 1 |
| Bursová, M | 1 |
| Coufal, P | 1 |
| Čabala, R | 1 |
| Barkoudah, E | 1 |
| Roy, CL | 1 |
| Lanot, A | 1 |
| Henri, P | 1 |
| Nowoczyn, M | 1 |
| Read, MH | 1 |
| Maucorps, C | 1 |
| Sassier, M | 1 |
| Lobbedez, T | 1 |
| Tchougang Nono, J | 1 |
| Mistretta, V | 1 |
| Noirot, I | 1 |
| Damas, P | 1 |
| Alhourani, HM | 1 |
| Kumar, A | 1 |
| George, LK | 1 |
| Sarwar, T | 1 |
| Wall, BM | 1 |
| Hitzing, S | 1 |
| Böttcher, A | 1 |
| Laube, M | 1 |
| Costello, M | 1 |
| Brennan, M | 1 |
| Newman, C | 1 |
| O'Shea, P | 1 |
| Bell, M | 1 |
| Spring, A | 1 |
| Owens, R | 1 |
| Fratita, M | 1 |
| O’Dwyer, M | 1 |
| Kanji, HD | 1 |
| Mithani, S | 1 |
| Boucher, P | 1 |
| Dias, VC | 1 |
| Yarema, MC | 1 |
| Liss, DB | 1 |
| Paden, MS | 1 |
| Schwarz, ES | 1 |
| Emmett, M | 2 |
| Luyasu, S | 1 |
| Wamelink, MM | 1 |
| Galanti, L | 1 |
| Dive, A | 1 |
| Vichot, AA | 1 |
| Rastegar, A | 1 |
| Abkur, TM | 1 |
| Mohammed, W | 1 |
| Ali, M | 1 |
| Casserly, L | 1 |
| Hulley, SL | 1 |
| Perring, J | 1 |
| Manning, N | 1 |
| Olpin, S | 1 |
| Yap, S | 1 |
| Weiler, S | 1 |
| Bellmann, R | 1 |
| Kullak-Ublick, GA | 1 |
| Kamran, H | 1 |
| Ram, N | 1 |
| Walker, V | 1 |
| Mills, GA | 1 |
| Anderson, ME | 1 |
| Ingle, BL | 1 |
| Jackson, JM | 1 |
| Moss, CL | 1 |
| Sharrod-Cole, H | 1 |
| Skipp, PJ | 1 |
| Lanoy, C | 1 |
| Bouckaert, Y | 1 |
| Jessurun, N | 1 |
| van Marum, R | 1 |
| Hermens, W | 1 |
| van Puijenbroek, E | 1 |
| Hunter, RW | 1 |
| Lawson, C | 1 |
| Galitsiou, E | 1 |
| Gifford, F | 1 |
| Neary, JJ | 1 |
| Bowron, A | 1 |
| Cooke, L | 1 |
| Scott, J | 1 |
| Stone, J | 1 |
| Rolleman, EJ | 1 |
| Hoorn, EJ | 1 |
| Didden, P | 1 |
| Zietse, R | 1 |
| Igarashi, H | 1 |
| Ito, T | 1 |
| Yoshinaga, M | 1 |
| Oono, T | 1 |
| Sakai, H | 1 |
| Takayanagi, R | 1 |
| Wiegand, TJ | 1 |
| Margaretten, M | 1 |
| Olson, KR | 1 |
| Holman, M | 1 |
| ter Maaten, JC | 1 |
| Lawrence, DT | 1 |
| Bechtel, LK | 1 |
| Charlton, NP | 1 |
| Holstege, CP | 1 |
| Green, TJ | 1 |
| Bijlsma, JJ | 1 |
| Sweet, DD | 1 |
| Reddi, AS | 1 |
| Kunadi, AR | 1 |
| Bodmer, M | 1 |
| Monte, AA | 1 |
| Zell-Kanter, M | 1 |
| Coleman, P | 1 |
| Whiteley, PM | 1 |
| Leikin, JB | 1 |
| Myall, K | 1 |
| Sidney, J | 1 |
| Marsh, A | 1 |
| Armenian, P | 1 |
| Gerona, RR | 1 |
| Blanc, PD | 1 |
| Wu, AH | 1 |
| Mookherjee, S | 1 |
| Verma, R | 1 |
| Polsani, KR | 1 |
| Wilt, J | 1 |
| Loehrke, ME | 1 |
| Nisse, P | 1 |
| Saulnier, F | 1 |
| Garat, A | 1 |
| Mathieu-Nolf, M | 1 |
| Veldhuijzen, N | 1 |
| Kamphuis, S | 1 |
| van den Bergh, F | 1 |
| Spronk, P | 1 |
| Braber, A | 1 |
| Amer, H | 1 |
| Dockery, F | 1 |
| Barrett, N | 1 |
| George, M | 1 |
| Witek, K | 1 |
| Stanton, J | 1 |
| Back, D | 1 |
| Zand, L | 1 |
| Muriithi, A | 1 |
| Nelsen, E | 1 |
| Franco, PM | 1 |
| Greene, EL | 1 |
| Qian, Q | 1 |
| El-Zoghby, ZM | 1 |
| Milosevic, S | 1 |
| Tran, K | 1 |
| O'Brien, B | 1 |
| Lee, KC | 1 |
| Palacios Jimenez, C | 1 |
| Alibhai, H | 1 |
| Chang, YM | 1 |
| Leckie, PJ | 1 |
| Baker, LA | 1 |
| Stanzani, G | 1 |
| L Priestnall, S | 1 |
| Mookerjee, RP | 1 |
| Jalan, R | 1 |
| Davies, NA | 1 |
| Steelman, R | 1 |
| Goodman, A | 1 |
| Biswas, S | 1 |
| Zimmerman, A | 1 |
| Tailor, P | 1 |
| Raman, T | 1 |
| Garganta, CL | 1 |
| Njalsson, R | 1 |
| Carlsson, K | 1 |
| Ristoff, E | 1 |
| Carey, HB | 1 |
| Humphreys, BD | 1 |
| Forman, JP | 1 |
| Zandi-Nejad, K | 1 |
| Bazari, H | 1 |
| Seifter, J | 1 |
| Magee, CC | 1 |
| Hori, Y | 1 |
| Fujisawa, M | 1 |
| Shimada, K | 1 |
| Hirose, Y | 1 |
| Yoshioka, T | 1 |
| Funk, GC | 1 |
| Doberer, D | 1 |
| Fuhrmann, V | 1 |
| Holzinger, U | 1 |
| Kitzberger, R | 1 |
| Kneidinger, N | 1 |
| Lindner, G | 1 |
| Schneeweiss, B | 1 |
| Peter, JV | 1 |
| Rogers, N | 1 |
| Murty, S | 1 |
| Gerace, R | 1 |
| Mackay, R | 1 |
| Peake, SL | 1 |
| Mendoza, CD | 1 |
| Heard, K | 1 |
| Dart, RC | 1 |
| Brooker, G | 1 |
| Jeffery, J | 1 |
| Nataraj, T | 1 |
| Sair, M | 1 |
| Ayling, R | 1 |
| Fenves, AZ | 1 |
| Kirkpatrick, HM | 1 |
| Patel, VV | 1 |
| Sweetman, L | 1 |
| Hodgman, MJ | 1 |
| Horn, JF | 1 |
| Stork, CM | 1 |
| Marraffa, JM | 1 |
| Holland, MG | 1 |
| Cantor, R | 1 |
| Carmel, PM | 1 |
| Zabrodski, RM | 1 |
| Schnurr, LP | 1 |
| Rabinovitz, M | 1 |
| Garty, M | 1 |
| Rosenfeld, JB | 1 |
| Zezulka, A | 1 |
| Wright, N | 2 |
| Mutimer, DJ | 1 |
| Ayres, RC | 1 |
| Neuberger, JM | 1 |
| Davies, MH | 1 |
| Holguin, J | 1 |
| Buckels, JA | 1 |
| Mayer, AD | 1 |
| McMaster, P | 1 |
| Elias, E | 1 |
| Pitt, JJ | 1 |
| Hauser, S | 1 |
| Roth, B | 1 |
| Woo, O | 1 |
| Blanc, P | 1 |
| Koulouris, Z | 1 |
| Tierney, MG | 1 |
| Jones, G | 1 |
| Al-Jubouri, MA | 1 |
| Yale, SH | 1 |
| Mazza, JJ | 1 |
| Katz, S | 1 |
| Pitt, WW | 1 |
| Mrochek, JE | 1 |
| Cohen, SB | 1 |
| Burk, RF | 1 |
| Harman, AW | 1 |
| Kyle, ME | 1 |
| Serroni, A | 1 |
| Farber, JL | 1 |
| Kritharides, L | 1 |
| Fassett, R | 1 |
| Singh, B | 1 |
| Flanagan, RJ | 1 |
| Mant, TG | 1 |
| Done, AK | 1 |
| Temple, AR | 1 |
| Proudfoot, AT | 1 |
10 reviews available for acetaminophen and Metabolic Acidosis
| Article | Year |
|---|---|
A Review Article on 5-Oxoproline Induced High Anion Gap Metabolic Acidosis.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Analgesics, Non-Narcotic; Female; Humans; Pyr | 2021 |
Severe Anion Gap Metabolic Acidosis Resulting from Combined Chronic Acetaminophen Toxicity and Starvation Ketosis: A Case Report and Literature Review.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged; Analgesics, Non-Narcotic; Humans; Ketosis; Mal | 2022 |
Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Animals; Antidotes; Cimetidine; Drug Overdose; Edetic Acid; | 2020 |
What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure?
Topics: Acetaminophen; Acetylcysteine; Acidosis; Amino Acid Metabolism, Inborn Errors; Analgesics, Non-Narco | 2013 |
Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adenosine Triphosphate; Analgesics, Non-Narcotic; An | 2014 |
[5-0xoproline (pyroglutamic acid) acidosis and acetaminophen- a differential diagnosis in high anion gap metabolic acidosis].
Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Biomarkers; Diagnosis, Differential; Humans; Medi | 2015 |
Recurrent anion gap metabolic acidosis in a woman with vertebral disc disease.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Analgesics, Non-Narcotic; Emergency Service, Hospita | 2011 |
A rare cause of high anion gap metabolic acidosis.
Topics: Abdominal Pain; Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Amino Acid Metabolism, Inborn | 2013 |
Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen.
Topics: Acetaminophen; Acid-Base Imbalance; Acidosis; Adolescent; Adult; Aged; Aged, 80 and over; Female; Hu | 2006 |
Treatment of salicylate poisoning.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Acute Kidney Injury; Alkalosis, Respiratory; Aspirin | 1971 |
72 other studies available for acetaminophen and Metabolic Acidosis
| Article | Year |
|---|---|
Pyroglutamic acidosis: an under-recognised cause of high anion gap metabolic acidosis.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged; Analgesics, Non-Narcotic; Bicarbonates; Female | 2021 |
[Plasmatic and urinary pyroglutamic acid measurement by capillary zone electrophoresis in chronic poisoning with acetaminophen in children].
Topics: Acetaminophen; Acidosis; Child; Electrophoresis, Capillary; Humans; Pharmaceutical Preparations; Pyr | 2021 |
5-Oxoproline acidosis caused by acetaminophen and flucloxacillin treatment - a case report.
Topics: Acetaminophen; Acidosis; Floxacillin; Humans; Pyrrolidonecarboxylic Acid | 2022 |
[A case of pyroglutamic metabolic acidosis after cotreatment by flucloxacillin and paracetamol].
Topics: Acetaminophen; Acetylcysteine; Acidosis; Aged; Floxacillin; Humans; Male; Methicillin | 2022 |
Metabolic Acidosis in a Pediatric Patient with Leukemia and Fungal Infection.
Topics: Acetaminophen; Acidosis; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Pro | 2020 |
Acquired pyroglutamic acidosis due to long-term dicloxacillin and paracetamol use.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Ba | 2020 |
Lessons of the month: Pyroglutamic acidosis: long-term paracetamol and a high anion gap.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Female; Glutathione Synthase; Hum | 2020 |
Flucloxacillin and paracetamol induced pyroglutamic acidosis.
Topics: Acetaminophen; Acidosis; Acute Kidney Injury; Aged; Anti-Bacterial Agents; Antipyretics; Bacteremia; | 2021 |
Malnourishment-Associated Acetaminophen Toxicity in Pregnancy.
Topics: Acetaminophen; Acidosis; Adult; Diagnosis, Differential; Female; Humans; Malnutrition; Poisoning; Pr | 2021 |
Letter to the Editor: A Further Possible Complication of Therapeutic Acetaminophen: Pyroglutamic Acidosis.
Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Humans | 2021 |
[Chronic paracetamol intoxication : under-diagnosed iatrogenic cause of metabolic acidosis with increased anion gap].
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Humans; Iatrogenic Disease; Pyrrolidonecarboxylic Ac | 2021 |
Metabolic acidosis caused by concomitant use of paracetamol (acetaminophen) and flucloxacillin? A case report and a retrospective study.
Topics: Acetaminophen; Acidosis; Aged; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Drug Interactions; F | 2017 |
Quantification of paracetamol and 5-oxoproline in serum by capillary electrophoresis: Implication for clinical toxicology.
Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Electrophoresis, Capillary; Humans; Pyrrolidoneca | 2017 |
The Many Shades of Dyspnea.
Topics: Acetaminophen; Acidosis; Aged, 80 and over; Analgesics, Non-Narcotic; Dyspnea; Female; Humans | 2018 |
[Acetaminophen induced 5-oxoproline acidosis: An uncommon case of high anion gap metabolic acidosis].
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged; Amino Acid Metabolism, Inborn Errors; Analgesi | 2018 |
[High anion gap metabolic acidosis (pyroglutamic acidosis) induced by chronic acetaminophen use].
Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Female; Humans; Middle Aged; Prescription Drug Ov | 2018 |
Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen.
Topics: Acetaminophen; Acidosis; Adult; Female; Humans; Pyrrolidonecarboxylic Acid; Recurrence; Treatment Ou | 2018 |
[Metabolic Acidosis under Acetaminophen Intake - an Unordinary Side Effect].
Topics: Acetaminophen; Acidosis; Aged; Amoxicillin; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Diagnos | 2018 |
Pyroglutamic acidosis.
Topics: Acetaminophen; Acidosis; Aged; Analgesics, Non-Narcotic; Humans; Male; Pain Management; Pyrrolidonec | 2019 |
An Under-Recognised Cause of Iatrogenic, Severe Metabolic Acidosis
Topics: Acetaminophen; Acetylcysteine; Acidosis; Aged, 80 and over; Anti-Bacterial Agents; Antipyretics; Art | 2019 |
Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity.
Topics: Acetaminophen; Acidosis; Aged; Analgesics, Non-Narcotic; Coma; Female; Humans; Methemoglobinemia | 2013 |
Pyroglutamic acid-induced metabolic acidosis: a case report.
Topics: Acetaminophen; Acidosis; Anti-Bacterial Agents; Antipyretics; Female; Fever; Floxacillin; Humans; Mi | 2014 |
Use of anion gap in the evaluation of a patient with metabolic acidosis.
Topics: Acetaminophen; Acetylcysteine; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Bicarbonates; Con | 2014 |
Acetaminophen-induced anion gap metabolic acidosis secondary to 5-oxoproline: a case report.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged; Analgesics, Non-Narcotic; Female; Humans; Pyrr | 2014 |
Transient 5-oxoprolinuria: unusually high anion gap acidosis in an infant.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Amino Acid Metabolism, Inborn Errors; Analgesics, No | 2015 |
Chronic Acetaminophen Use Associated with Anion-Gap Metabolic Acidosis.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Analgesics, Non-Narcotic; Female; Humans; Tim | 2016 |
The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis?
Topics: Acetaminophen; Acidosis; Benzoquinones; Glutathione; Glutathione Synthase; Imines | 2017 |
Metabolic acidosis and 5-oxoprolinuria induced by flucloxacillin and acetaminophen: a case report.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Amino Acid Metabolism, Inborn Err | 2016 |
Advanced Age and Female Sex As Risk Factors for High Anion Gap Metabolic Acidosis After a Drug Interaction Between Paracetamol and Flucloxacillin: A Case Series.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Age Factors; Aged; Aged, 80 and over; Analgesics, No | 2016 |
Pyroglutamic acidosis in association with therapeutic paracetamol use.
Topics: Acetaminophen; Acidosis; Adult; Aged; Analgesics, Non-Narcotic; Female; Humans; Male; Middle Aged; P | 2016 |
Paracetamol-induced 5-oxoprolinuira and high anion gap metabolic acidosis in a child on a ketogenic diet.
Topics: Acetaminophen; Acidosis; Amino Acid Metabolism, Inborn Errors; Analgesics; Child; Diet; Humans; Keto | 2008 |
Guilty as charged: unmeasured urinary anions in a case of pyroglutamic acidosis.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged; Anions; Anti-Bacterial Agents; Cations; Female | 2008 |
Acetaminophen-induced acute pancreatitis. A case report.
Topics: Acetaminophen; Acidosis; Adult; Drug Overdose; Female; Humans; Pancreatitis | 2009 |
Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with IV NAC and continuous venovenous hemodiafiltration.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Antidotes; Coma; Combined Modalit | 2010 |
[Severe metabolic acidosis as a result of 5-oxoproline in acetaminophen use].
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Female; Humans; Pyrrolidonecarbox | 2010 |
5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acid-Base Equilibrium; Acidosis; Acute Disease; Adult; Analgesics, No | 2010 |
Profound metabolic acidosis from pyroglutamic acidemia: an underappreciated cause of high anion gap metabolic acidosis.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Diagnosis, Differential; Female; Humans; Opio | 2010 |
"Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with iv nac and continuous venovenous hemodiafiltration" by Wiegand et al., Clin Toxicol (Phila) 48:156-159.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Coma; Drug Overdose; Half-Life; H | 2010 |
A gargantuan acetaminophen level in an acidemic patient treated solely with intravenous N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; | 2013 |
Mind the gap! An unusual metabolic acidosis.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Anti-Bacterial Agents; Antioxidants; Female; Floxacillin; H | 2011 |
5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use.
Topics: Acetaminophen; Acetylcysteine; Acid-Base Equilibrium; Acidosis; Adult; Amino Acid Metabolism, Inborn | 2012 |
5-Oxoprolinuria as a cause of high anion gap metabolic acidosis.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Amino Acid Metabolism, Inborn Errors; Bicarbo | 2012 |
[Early coma and metabolic acidosis after massive paracetamol self poisoning].
Topics: Acetaminophen; Acidosis; Coma; Female; Humans; Middle Aged | 2012 |
Madam, why are you so sour? Cause, diagnosis and complication of 5-oxoprolinemia.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged; Amino Acid Metabolism, Inborn Errors; Analgesi | 2012 |
Refractory metabolic acidosis in patients with sepsis following hemiarthroplasty for femoral neck fracture: a causative role for paracetamol and flucloxacillin?
Topics: Acetaminophen; Acidosis; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Female; | 2011 |
Severe anion gap metabolic acidosis from acetaminophen use secondary to 5-oxoproline (pyroglutamic acid) accumulation.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Acute Disease; Aged; Analgesics, Non-Narcotic; Femal | 2012 |
A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Animals; Biomarkers; Cardiovascular Diseases; Chemic | 2013 |
Metabolic acidosis and coma in a child with acetaminophen toxicity.
Topics: Acetaminophen; Acidosis; Coma; Female; Humans; Infant | 2004 |
Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid).
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Amino Acid Metabolism, Inborn Errors; Anorexia; Bica | 2005 |
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Analgesics, Non-Narcotic; Antineoplastic Comb | 2005 |
Method for screening and quantitative determination of serum levels of salicylic Acid, acetaminophen, theophylline, phenobarbital, bromvalerylurea, pentobarbital, and amobarbital using liquid chromatography/electrospray mass spectrometry.
Topics: Acetaminophen; Acidosis; Adult; Amobarbital; Analgesics, Non-Narcotic; Bromisovalum; Calibration; Ch | 2006 |
The acidifying effect of lactate is neutralized by the alkalinizing effect of hypoalbuminemia in non-paracetamol-induced acute liver failure.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Albumins; Analgesics, Non-Narcotic; Case-Cont | 2006 |
An unusual cause of severe metabolic acidosis.
Topics: Acetaminophen; Acidosis; Acute Kidney Injury; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Floxa | 2006 |
Coma, metabolic acidosis and normal liver function in a child with a large serum acetaminophen level.
Topics: Acetaminophen; Acidosis; Child, Preschool; Coma; Drug-Related Side Effects and Adverse Reactions; Fe | 2006 |
High anion gap metabolic acidosis secondary to pyroglutamic aciduria (5-oxoprolinuria): association with prescription drugs and malnutrition.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Ba | 2007 |
Profound metabolic acidosis and oxoprolinuria in an adult.
Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Critical Illness; Female; Humans; Metabolic Disea | 2007 |
Anion gap acidosis with hypoglycemia in acetaminophen toxicity.
Topics: Acetaminophen; Acid-Base Imbalance; Acidosis; Acute Kidney Injury; Adult; Chemical and Drug Induced | 1984 |
[Rare side effects following paracetamol poisoning].
Topics: Acetaminophen; Acidosis; Adolescent; Chemical and Drug Induced Liver Injury; Female; Humans; Methemo | 1984 |
Severe metabolic acidosis early in paracetamol poisoning.
Topics: Acetaminophen; Acidosis; Female; Humans; Lactates; Middle Aged; Time Factors | 1982 |
Metabolic acidosis in paracetamol poisoning.
Topics: Acetaminophen; Acidosis; Adolescent; Adult; Female; Humans; Lactates | 1982 |
Serious paracetamol poisoning and the results of liver transplantation.
Topics: Acetaminophen; Acidosis; Adolescent; Adult; Aged; Female; Hepatic Encephalopathy; Humans; Liver Fail | 1994 |
Transient 5-oxoprolinuria and high anion gap metabolic acidosis: clinical and biochemical findings in eleven subjects.
Topics: 3-Hydroxybutyric Acid; Acetaminophen; Acidosis; Adolescent; Adult; Aged; Aged, 80 and over; Analgesi | 1998 |
Early metabolic acidosis and coma after acetaminophen ingestion.
Topics: Acetaminophen; Acidosis; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Live | 1999 |
Metabolic acidosis and coma following a severe acetaminophen overdose.
Topics: Acetaminophen; Acidosis; Adult; Coma; Drug Overdose; Female; Humans | 1999 |
Metabolic acidosis and coma after acetaminophen ingestion.
Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Coma; Humans | 1999 |
Anion gap acidosis associated with acetaminophen.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Analgesics, Non-Narcotic; Female; Humans; Pyr | 2000 |
Comparative serum and urine analyses by dual-detector anion-exchange chromatography.
Topics: Absorption; Acetaminophen; Acidosis; Chromatography, Ion Exchange; Humans; Hydrogen-Ion Concentratio | 1975 |
Acetaminophen overdoses at a county hospital: a year's experience.
Topics: Acetaminophen; Acidosis; Adult; Amylases; Chemical and Drug Induced Liver Injury; Female; Hospitals, | 1978 |
The killing of cultured hepatocytes by N-acetyl-p-benzoquinone imine (NAPQI) as a model of the cytotoxicity of acetaminophen.
Topics: Acetaminophen; Acidosis; Adenosine Triphosphate; Animals; Benzoflavones; Benzoquinones; beta-Naphtho | 1991 |
Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure.
Topics: Acetaminophen; Acidosis; Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Coma; F | 1988 |
Coma and metabolic acidosis early in severe acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Adolescent; Aged; Blood Gas Analysis; Chemical and Drug Ind | 1986 |
Acute paracetamol poisoning.
Topics: Acetaminophen; Acidosis; Acute Disease; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and D | 1970 |