acetaminophen has been researched along with Menstruation, Painful in 44 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy and safety of IV tramadol versus IV paracetamol in relieving acute pain of primary dysmenorrhea." | 9.34 | Efficacy and Safety of Intravenous Tramadol versus Intravenous Paracetamol for Relief of Acute Pain of Primary Dysmenorrhea: A Randomized Controlled Trial. ( Abbas, AM; Alalfy, M; AlAmodi, AA; Ali, AS; Fadlalmola, HA; Ghamry, NK; Hamza, M; Islam, Y; Mahmoud, AO; Shareef, MA, 2020) |
| "To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department." | 9.27 | Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial ( Eken, C; Karcıoğlu, Ö; Serinken, M, 2018) |
| "The purpose of this study was to compare acetaminophen with ibuprofen for pain relief and menstrual fluid prostaglandin F2alpha (PGF2alpha) suppression in primary dysmenorrhea." | 9.12 | Clinical efficacy and differential inhibition of menstrual fluid prostaglandin F2alpha in a randomized, double-blind, crossover treatment with placebo, acetaminophen, and ibuprofen in primary dysmenorrhea. ( Dawood, MY; Khan-Dawood, FS, 2007) |
| "To determine if pain relief provided by a wearable heat wrap (continuous, low-level, topical heat therapy) is superior to oral acetaminophen for primary dysmenorrhea." | 9.11 | Continuous, low-level, topical heat wrap therapy as compared to acetaminophen for primary dysmenorrhea. ( Akin, M; Erasala, G; Hurley, G; Price, W; Rodriguez, G; Smith, RP, 2004) |
| " Naproxen 400 mg provided greater pain relief than acetaminophen and placebo within 30 minutes of administration (P < 0." | 9.10 | Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. ( Akin, MD; Dawood, MY; Milsom, I; Minic, M; Niland, NF; Spann, J; Squire, RA, 2002) |
| "The effects of ibuprofen (400 mg), naproxen sodium (250 mg) and paracetamol (500 mg) on intrauterine pressure and menstrual pain was assessed in 12 women with dysmenorrhoea in a double-blind parallel study." | 9.05 | Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea. ( Andersch, B; Milsom, I, 1984) |
| "The drug combination including isoxsuprine 10 mg, acetaminophen 250 mg and caffeine 30 mg was administered to 80 patients divided into two groups, 40 with premenstrual tension and 40 with clinically diagnosed primary dysmenorrhoea." | 9.04 | Isoxsuprine in primary dysmenorrhoea. Its effectiveness in premenstrual tension. ( Flores-Mercado, F; Gallegos-Torres, J, 1975) |
| " The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243." | 8.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| "The aim of this study was to compare the efficiency of diclofenac sodium to paracetamol using a visual analog scale in the patients presenting to the emergency room with primary dysmenorrhea." | 7.79 | [Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale]. ( Arıcı, S; Ayan, M; Demirtürk, F; Esen, M; Karaman, S; Söğüt, E; Taş, U, 2013) |
| "Dysmenorrhea is caused by the discharge of prostaglandins into the uterine tissue; therefore, non-steroidal anti-inflammatory drugs (NSAIDs) are the established initial therapy for dysmenorrhea." | 6.82 | Naproxen, paracetamol and pamabrom versus paracetamol, pyrilamine and pamabrom in primary dysmenorrhea: a randomized, double-blind clinical trial. ( González-de la Parra, M; Murguía-Cánovas, G; Ortiz, MI; Silva, R; Vargas-López, LC, 2016) |
| "To compare the efficacy and safety of IV tramadol versus IV paracetamol in relieving acute pain of primary dysmenorrhea." | 5.34 | Efficacy and Safety of Intravenous Tramadol versus Intravenous Paracetamol for Relief of Acute Pain of Primary Dysmenorrhea: A Randomized Controlled Trial. ( Abbas, AM; Alalfy, M; AlAmodi, AA; Ali, AS; Fadlalmola, HA; Ghamry, NK; Hamza, M; Islam, Y; Mahmoud, AO; Shareef, MA, 2020) |
| "To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department." | 5.27 | Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial ( Eken, C; Karcıoğlu, Ö; Serinken, M, 2018) |
| "The purpose of this study was to compare acetaminophen with ibuprofen for pain relief and menstrual fluid prostaglandin F2alpha (PGF2alpha) suppression in primary dysmenorrhea." | 5.12 | Clinical efficacy and differential inhibition of menstrual fluid prostaglandin F2alpha in a randomized, double-blind, crossover treatment with placebo, acetaminophen, and ibuprofen in primary dysmenorrhea. ( Dawood, MY; Khan-Dawood, FS, 2007) |
| "To determine if pain relief provided by a wearable heat wrap (continuous, low-level, topical heat therapy) is superior to oral acetaminophen for primary dysmenorrhea." | 5.11 | Continuous, low-level, topical heat wrap therapy as compared to acetaminophen for primary dysmenorrhea. ( Akin, M; Erasala, G; Hurley, G; Price, W; Rodriguez, G; Smith, RP, 2004) |
| " Naproxen 400 mg provided greater pain relief than acetaminophen and placebo within 30 minutes of administration (P < 0." | 5.10 | Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. ( Akin, MD; Dawood, MY; Milsom, I; Minic, M; Niland, NF; Spann, J; Squire, RA, 2002) |
| "The effects of ibuprofen (400 mg), naproxen sodium (250 mg) and paracetamol (500 mg) on intrauterine pressure and menstrual pain was assessed in 12 women with dysmenorrhoea in a double-blind parallel study." | 5.05 | Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea. ( Andersch, B; Milsom, I, 1984) |
| "Twenty-five patients suffering from primary dysmenorrhoea took part in a double-blind crossover study which demonstrated flurbiprofen (100 mg three times a day) to be significantly more effective than paracetamol (1 g three times a day) in providing pain relief on Days 1 and 2, and on the worst day of pain." | 5.05 | A comparison of flurbiprofen and paracetamol in the treatment of primary dysmenorrhoea. ( Maclean, D, 1983) |
| "In a double-blind corss-over trial, 30 patients experiencing primary dysmenorrhea were treated with 2 prostaglandin inhibitors, mefenamic acid (250mg) and flufenamic acid (100 mg), and an analgesia, dexhropropoxyphene (32." | 5.04 | Trial of prostaglandin-synthetase inhibitors in primary dysmenorrhoea. ( Anderson, AB; Fraser, IS; Haynes, PJ; Turnbull, AC, 1978) |
| "The drug combination including isoxsuprine 10 mg, acetaminophen 250 mg and caffeine 30 mg was administered to 80 patients divided into two groups, 40 with premenstrual tension and 40 with clinically diagnosed primary dysmenorrhoea." | 5.04 | Isoxsuprine in primary dysmenorrhoea. Its effectiveness in premenstrual tension. ( Flores-Mercado, F; Gallegos-Torres, J, 1975) |
| " The earlier review included 20 studies (7238 participants) in valid comparisons, but because we used different outcomes for some headache studies, the number of participants in the analyses of the effects of caffeine is now 4262 when previously it was 5243." | 4.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| "The aim of this study was to compare the efficiency of diclofenac sodium to paracetamol using a visual analog scale in the patients presenting to the emergency room with primary dysmenorrhea." | 3.79 | [Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale]. ( Arıcı, S; Ayan, M; Demirtürk, F; Esen, M; Karaman, S; Söğüt, E; Taş, U, 2013) |
| "Two commonly taken over-the-counter analgesics, aspirin and acetaminophen, were compared for: effect on total menstrual loss, effect on total days of menstruation, and effect in reduction of pain due to headaches and/or menstrual cramps." | 3.67 | Do aspirin and acetaminophen affect total menstrual loss? ( Agna, MA; Pendergrass, PB; Ream, LJ; Scott, JN, 1984) |
| "Both drugs reduced menstrual pain." | 2.87 | Effect of Ginger and Novafen on menstrual pain: A cross-over trial. ( Adib Rad, H; Bakouei, F; Basirat, Z; Farhadi Kotenaei, Z; Kazemi, S; Khafri, S; Moghadamnia, AA; Nikpour, M, 2018) |
| "Treatment with mefenamic acid resulted in less volume of blood loss compared to tranexamic acid (MD -64." | 2.82 | Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine-device use. ( Christelle, K; Jaafar, SH; Norhayati, MN, 2022) |
| "Dysmenorrhea is caused by the discharge of prostaglandins into the uterine tissue; therefore, non-steroidal anti-inflammatory drugs (NSAIDs) are the established initial therapy for dysmenorrhea." | 2.82 | Naproxen, paracetamol and pamabrom versus paracetamol, pyrilamine and pamabrom in primary dysmenorrhea: a randomized, double-blind clinical trial. ( González-de la Parra, M; Murguía-Cánovas, G; Ortiz, MI; Silva, R; Vargas-López, LC, 2016) |
| "Changes in menstrual pain intensity and duration, amount of bleeding measured according to the number of daily pads used and concomitant symptoms were assessed on the fifth day of each cycle." | 2.70 | Antispasmodic/analgesic associations in primary dysmenorrhea double-blind crossover placebo-controlled clinical trial. ( de los Santos, AR; Di Girolamo, G; Martí, ML; Pérez Macri, S; Zmijanovich, R, 2001) |
| "Oral isoxsuprine was compared with placebo in two trials; terbutaline oral spray, ritodrine chloride and oral hydroxyphenyl-orciprenalin were compared with placebo in a further three trials." | 2.48 | Beta2-adrenoceptor agonists for dysmenorrhoea. ( Beaman, JH; Ejaz, K; Fedorowicz, Z; Jagannath, VA; Nasser, M; van Zuuren, EJ, 2012) |
| "Acetaminophen displays good gastrointestinal tolerance without any effect on haemostasis." | 2.42 | Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea? ( De Los Santos, AR; Di Girolamo, G; González, CD; Sánchez, AJ, 2004) |
| "Dysmenorrhea was common among adolescent girls in our study population, and was found to affect their mental status." | 1.39 | Knowledge and attitudes towards dysmenorrhea among adolescent girls in an urban school in Sri Lanka. ( Suresh, TS; Wijesiri, HS, 2013) |
| "Young women with Rett syndrome have standard symptoms of dysmenorrhea and PMS as well as autism spectrum specific PMS symptoms." | 1.38 | Rett syndrome and menstruation. ( Hamilton, A; Marshal, MP; Murray, PJ; Sucato, GS, 2012) |
| "The pain is often not completely relieved despite the use of medication." | 1.36 | Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment. ( Ortiz, MI, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (38.64) | 18.7374 |
| 1990's | 1 (2.27) | 18.2507 |
| 2000's | 12 (27.27) | 29.6817 |
| 2010's | 12 (27.27) | 24.3611 |
| 2020's | 2 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Christelle, K | 1 |
| Norhayati, MN | 1 |
| Jaafar, SH | 1 |
| Daniels, SE | 1 |
| Paredes-Diaz, A | 1 |
| An, R | 1 |
| Centofanti, R | 1 |
| Tajaddini, A | 1 |
| Ghamry, NK | 1 |
| Ali, AS | 1 |
| Shareef, MA | 1 |
| AlAmodi, AA | 1 |
| Hamza, M | 1 |
| Abbas, AM | 1 |
| Fadlalmola, HA | 1 |
| Alalfy, M | 1 |
| Mahmoud, AO | 1 |
| Islam, Y | 1 |
| Serinken, M | 1 |
| Eken, C | 1 |
| Karcıoğlu, Ö | 1 |
| Adib Rad, H | 1 |
| Basirat, Z | 1 |
| Bakouei, F | 1 |
| Moghadamnia, AA | 1 |
| Khafri, S | 1 |
| Farhadi Kotenaei, Z | 1 |
| Nikpour, M | 1 |
| Kazemi, S | 1 |
| Ayan, M | 1 |
| Taş, U | 1 |
| Söğüt, E | 1 |
| Arıcı, S | 1 |
| Karaman, S | 1 |
| Esen, M | 1 |
| Demirtürk, F | 1 |
| Derry, CJ | 1 |
| Derry, S | 1 |
| Moore, RA | 1 |
| Ortiz, MI | 3 |
| Murguía-Cánovas, G | 1 |
| Vargas-López, LC | 1 |
| Silva, R | 1 |
| González-de la Parra, M | 1 |
| Ponce-Monter, HA | 1 |
| Mora-Rodríguez, JA | 1 |
| Barragán-Ramírez, G | 1 |
| Barrón-Guerrero, BS | 1 |
| Latthe, PM | 1 |
| Champaneria, R | 1 |
| Khan, KS | 1 |
| Hamilton, A | 1 |
| Marshal, MP | 1 |
| Sucato, GS | 1 |
| Murray, PJ | 1 |
| Fedorowicz, Z | 1 |
| Nasser, M | 1 |
| Jagannath, VA | 1 |
| Beaman, JH | 1 |
| Ejaz, K | 1 |
| van Zuuren, EJ | 1 |
| Wijesiri, HS | 1 |
| Suresh, TS | 1 |
| Milsom, I | 3 |
| Minic, M | 1 |
| Dawood, MY | 2 |
| Akin, MD | 1 |
| Spann, J | 1 |
| Niland, NF | 1 |
| Squire, RA | 1 |
| Di Girolamo, G | 2 |
| Sánchez, AJ | 1 |
| De Los Santos, AR | 2 |
| González, CD | 1 |
| Idänpään-Heikkilä, JE | 1 |
| Idänpään-Heikkilä, JJ | 1 |
| Klaukka, T | 1 |
| Proctor, M | 3 |
| Farquhar, C | 3 |
| Akin, M | 1 |
| Price, W | 1 |
| Rodriguez, G | 1 |
| Erasala, G | 1 |
| Hurley, G | 1 |
| Smith, RP | 1 |
| Proctor, ML | 1 |
| Farquhar, CM | 1 |
| Khan-Dawood, FS | 1 |
| Ali, Z | 1 |
| Burnett, I | 1 |
| Eccles, R | 1 |
| North, M | 1 |
| Jawad, M | 1 |
| Jawad, S | 1 |
| Clarke, G | 1 |
| Frank, GJ | 1 |
| Kefford, RH | 1 |
| Andersch, B | 1 |
| Maclean, D | 1 |
| Pendergrass, PB | 1 |
| Ream, LJ | 1 |
| Scott, JN | 1 |
| Agna, MA | 1 |
| Williams, AA | 1 |
| Backhouse, CI | 1 |
| Langrick, AF | 1 |
| Gunn, AD | 1 |
| Mettler, L | 1 |
| Sadighi, R | 1 |
| Zhang, WY | 1 |
| Li Wan Po, A | 1 |
| Zmijanovich, R | 1 |
| Pérez Macri, S | 1 |
| Martí, ML | 1 |
| Baker, FC | 1 |
| Driver, HS | 1 |
| Paiker, J | 1 |
| Rogers, GG | 1 |
| Mitchell, D | 1 |
| Anderson, AB | 1 |
| Haynes, PJ | 1 |
| Fraser, IS | 1 |
| Turnbull, AC | 1 |
| Gallegos-Torres, J | 1 |
| Flores-Mercado, F | 1 |
| Janbu, T | 2 |
| Løkken, P | 2 |
| Nesheim, BI | 2 |
| Beynon, CL | 1 |
| Flores Mercado, F | 1 |
| Gallegos Torres, J | 1 |
| Ogden, JA | 1 |
| Wade, ME | 1 |
| Anderson, G | 1 |
| Davis, CD | 1 |
| Hartel, J | 1 |
| Lyell, A | 1 |
| Alexander, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind, Randomized, Crossover Study to Assess Menstrual Cramp Pain Associated With Primary Dysmenorrhea[NCT03448536] | Phase 4 | 201 participants (Actual) | Interventional | 2018-04-05 | Completed | ||
| Comparison of Dexketoprofen, Paracetamol and Ibuprofen in the Treatment of Primary Dysmenorrhea[NCT03697746] | 300 participants (Anticipated) | Interventional | 2018-10-01 | Not yet recruiting | |||
| The Effect of Post Colonoscopy Abdominal Massage on Abdominal Pain, Distension, Discomfort and Patient Satisfaction: A Randomized Controlled Study Protocol[NCT04979351] | 180 participants (Actual) | Interventional | 2020-11-09 | Active, not recruiting | |||
| Perioperative Regular Usage of Propacetamol to Reduce Post Cesarean Section Uterine Contraction Pain and Opioid Consumption[NCT03878082] | 100 participants (Actual) | Interventional | 2019-08-12 | Completed | |||
| A Randomized, Crossover, Pilot Trial of the Feasibility and Safety of Acupoint Injection of Vitamin K for Treatment of Primary Dysmenorrhea[NCT00995917] | 18 participants (Actual) | Interventional | 2009-10-31 | Completed | |||
| Assessment of Mediacal Taping Concept Self-applied, in the Treatment of Primary Dysmenorrhea[NCT02114723] | 129 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| Effect of Transcutaneous Electrical Nerve Stimulation (TENS) on Amelioration of Pain Associated With Primary Dysmenorrhea in Female Undergraduates of a Nigerian University[NCT03446859] | 25 participants (Actual) | Interventional | 2017-08-04 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Pain intensity was measured using Numerical Rating Scale (from 0 to 10: 0 = no pain, 10 = worst possible pain). For each postdose time point, pain intensity differences (PIDs) were derived by subtracting the pain intensity at the postdose time point from the baseline intensity score (baseline score - post-baseline score). A positive difference was indicative of improvement. Time-weighted summed pain intensity differences (SPIDs) were calculated by multiplying the PID score at each postdose time point by the duration (in hours) since the preceding time point and then summing these values. The minimum value could be -55, and the maximum value could be 55. (NCT03448536)
Timeframe: Up to 6 hours post-dose
| Intervention | Scores on a scale * hours (Least Squares Mean) |
|---|---|
| Naproxen Sodium | 23.47 |
| Acetaminophen | 21.94 |
Pain intensity was measured using Numerical Rating Scale (from 0 to 10: 0 = no pain, 10 = worst possible pain). For each postdose time point, pain intensity differences (PIDs) were derived by subtracting the pain intensity at the postdose time point from the baseline intensity score (baseline score - post-baseline score). A positive difference was indicative of improvement. Time-weighted summed pain intensity differences (SPIDs) were calculated by multiplying the PID score at each postdose time point by the duration (in hours) since the preceding time point and then summing these values. The minimum value could be -60, and the maximum value could be 60. (NCT03448536)
Timeframe: From 6 hours to 12 hours post-dose
| Intervention | Scores on a scale * hours (Least Squares Mean) |
|---|---|
| Naproxen Sodium | 30.15 |
| Acetaminophen | 21.88 |
Pain relief was measured using Categorical Pain Relief Rating Scale (0 = No relief, 1 = a little relief, 2 = some relief, 3 = a lot of relief, 4 = complete relief). Total pain relief scores (TOTPARs) were calculated by multiplying the pain relief score at each postdose time point by the duration (in hours) since the preceding time point and then summing these values. The minimum value is 0, and the maximum value is 46. Higher scores was indicative of more pain relief. (NCT03448536)
Timeframe: Up to 12 hours post-dose
| Intervention | Scores on a scale * hours (Least Squares Mean) |
|---|---|
| Naproxen Sodium | 29.18 |
| Acetaminophen | 24.87 |
Pain intensity was measured using Numerical Rating Scale (from 0 to 10: 0 = no pain, 10 = worst possible pain). For each postdose time point, pain intensity differences (PIDs) were derived by subtracting the pain intensity at the postdose time point from the baseline intensity score (baseline score - post-baseline score). A positive difference was indicative of improvement. Time-weighted summed pain intensity differences (SPIDs) were calculated by multiplying the PID score at each postdose time point by the duration (in hours) since the preceding time point and then summing these values. The minimum value could be -115, and the maximum value could be 115. (NCT03448536)
Timeframe: Up to 12 hours post-dose
| Intervention | Scores on a scale * hours (Least Squares Mean) |
|---|---|
| Naproxen Sodium | 53.62 |
| Acetaminophen | 43.82 |
Time to first intake of rescue medication was defined as the number of hours elapsed between time of dose and time of rescue medication in each treatment period. Participants would be censored at time of last pain assessment. (NCT03448536)
Timeframe: Up to 12 hours post-dose
| Intervention | Hours (Median) |
|---|---|
| Naproxen Sodium | NA |
| Acetaminophen | NA |
Pain relief was measured using Categorical Pain Relief Rating Scale (0 = No relief, 1 = a little relief, 2 = some relief, 3 = a lot of relief, 4 = complete relief). Total pain relief scores (TOTPARs) were calculated by multiplying the pain relief score at each postdose time point by the duration (in hours) since the preceding time point and then summing these values. The minimum value is 0, and the maximum value is 24. Higher scores was indicative of more pain relief. (NCT03448536)
Timeframe: From 6 hours to 12 hours post-dose
| Intervention | Scores on a scale * hours (Least Squares Mean) |
|---|---|
| Naproxen Sodium | 15.72 |
| Acetaminophen | 11.97 |
Pain relief was measured using Categorical Pain Relief Rating Scale (0 = No relief, 1 = a little relief, 2 = some relief, 3 = a lot of relief, 4 = complete relief). Total pain relief scores (TOTPARs) were calculated by multiplying the pain relief score at each postdose time point by the duration (in hours) since the preceding time point and then summing these values. The minimum value is 0, and the maximum value is 22. Higher scores was indicative of more pain relief. (NCT03448536)
Timeframe: Up to 6 hours post-dose
| Intervention | Scores on a scale * hours (Least Squares Mean) |
|---|---|
| Naproxen Sodium | 13.46 |
| Acetaminophen | 12.90 |
Global evaluation was performed either at 12 hours post-dose or immediately prior to the first intake of rescue medication. Global Evaluation Score was based on the question 'Overall, I would rate the effectiveness of the study medication in relieving my menstrual pain as: 0=Poor, 1=Fair, 2=Good, 3=Very Good, 4=Excellent.' (NCT03448536)
Timeframe: Up to 12 hours post-dose
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| Poor | Fair | Good | Very good | Excellent | |
| Acetaminophen | 13 | 42 | 38 | 38 | 25 |
| Naproxen Sodium | 10 | 26 | 25 | 60 | 35 |
Pain intensity was measured using Numerical Rating Scale (from 0 to 10: 0 = no pain, 10 = worst possible pain). For each postdose time point, pain intensity differences (PIDs) were derived by subtracting the pain intensity at the postdose time point from the baseline intensity score (baseline score - post-baseline score). A positive difference was indicative of improvement. (NCT03448536)
Timeframe: Up to 12 hours post-dose
| Intervention | Scores on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| 30 minutes | 1 hour | 3 hours | 6 hours | 9 hours | 12 hours | |
| Acetaminophen | 0.9 | 2.1 | 4.0 | 4.3 | 3.6 | 3.5 |
| Naproxen Sodium | 0.8 | 1.9 | 4.1 | 5.1 | 4.9 | 5.0 |
Pain relief was measured using Categorical Pain Relief Rating Scale (0 = No relief, 1 = a little relief, 2 = some relief, 3 = a lot of relief, 4 = complete relief). (NCT03448536)
Timeframe: Up to 12 hours post-dose
| Intervention | Scores on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| 30 minutes | 1 hour | 3 hours | 6 hours | 9 hours | 12 hours | |
| Acetaminophen | 0.9 | 1.6 | 2.3 | 2.4 | 2.0 | 1.9 |
| Naproxen Sodium | 0.9 | 1.4 | 2.3 | 2.7 | 2.6 | 2.7 |
11 reviews available for acetaminophen and Menstruation, Painful
| Article | Year |
|---|---|
Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine-device use.
Topics: Acetaminophen; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dysmenorrhea; Female; Hum | 2022 |
Caffeine as an analgesic adjuvant for acute pain in adults.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics; Caffeine; Chemotherapy, Adjuvant; Di | 2014 |
Dysmenorrhoea.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Denervation; Dysme | 2011 |
Beta2-adrenoceptor agonists for dysmenorrhoea.
Topics: Acetaminophen; Adolescent; Adrenergic beta-2 Receptor Agonists; Adult; Caffeine; Dysmenorrhea; Femal | 2012 |
Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Clinical Trials as Topic; Drug Combinations; Drug Therapy, | 2004 |
[Treatment for inflammation related pain--COX-2 inhibitors knocking on the door].
Topics: Acetaminophen; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; Ibupr | 2004 |
Dysmenorrhoea.
Topics: Acetaminophen; Acupuncture Therapy; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Contraceptives | 2003 |
Dysmenorrhoea.
Topics: Acetaminophen; Acupuncture Therapy; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Contraceptives | 2003 |
Dysmenorrhoea.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drugs, Chinese Herbal; Dysmenorrhea | 2004 |
Dysmenorrhoea.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drugs, Chinese Herbal; Dysmenorrhea | 2006 |
Efficacy of minor analgesics in primary dysmenorrhoea: a systematic review.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, No | 1998 |
23 trials available for acetaminophen and Menstruation, Painful
| Article | Year |
|---|---|
Significant, long-lasting pain relief in primary dysmenorrhea with low-dose naproxen sodium compared with acetaminophen: a double-blind, randomized, single-dose, crossover study.
Topics: Acetaminophen; Adult; Analgesics; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind | 2019 |
Efficacy and Safety of Intravenous Tramadol versus Intravenous Paracetamol for Relief of Acute Pain of Primary Dysmenorrhea: A Randomized Controlled Trial.
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Adolescent; Adult; Analgesics, Non-Narcotic; | 2020 |
Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dysmenorrhea; Female; H | 2018 |
Effect of Ginger and Novafen on menstrual pain: A cross-over trial.
Topics: Acetaminophen; Adolescent; Adult; Caffeine; Cross-Over Studies; Drug Combinations; Dysmenorrhea; Fem | 2018 |
Naproxen, paracetamol and pamabrom versus paracetamol, pyrilamine and pamabrom in primary dysmenorrhea: a randomized, double-blind clinical trial.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double | 2016 |
Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over | 2002 |
Continuous, low-level, topical heat wrap therapy as compared to acetaminophen for primary dysmenorrhea.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Dysmenorrhea; Female; Hot Temperature; Humans; Multi | 2004 |
Continuous, low-level, topical heat wrap therapy as compared to acetaminophen for primary dysmenorrhea.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Dysmenorrhea; Female; Hot Temperature; Humans; Multi | 2004 |
Continuous, low-level, topical heat wrap therapy as compared to acetaminophen for primary dysmenorrhea.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Dysmenorrhea; Female; Hot Temperature; Humans; Multi | 2004 |
Continuous, low-level, topical heat wrap therapy as compared to acetaminophen for primary dysmenorrhea.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Dysmenorrhea; Female; Hot Temperature; Humans; Multi | 2004 |
Clinical efficacy and differential inhibition of menstrual fluid prostaglandin F2alpha in a randomized, double-blind, crossover treatment with placebo, acetaminophen, and ibuprofen in primary dysmenorrhea.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Body Fluids; Cross-Over Studies; Dinoprost; Double-B | 2007 |
Efficacy of a paracetamol and caffeine combination in the treatment of the key symptoms of primary dysmenorrhoea.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Caffeine; Central Nervous System Stimula | 2007 |
Report of a double-blind crossover study to compare flurbiprofen with paracetamol in the treatment of primary dysmenorrhoea.
Topics: Acetaminophen; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Flurbiprofen; Hu | 1983 |
Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; I | 1984 |
A comparison of flurbiprofen and paracetamol in the treatment of primary dysmenorrhoea.
Topics: Acetaminophen; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Double-Blind Method; Dysmenorrhe | 1983 |
A general practice study of naproxen sodium and a dextropropoxyphene-paracetamol combination in primary dysmenorrhoea.
Topics: Acetaminophen; Adolescent; Adult; Dextropropoxyphene; Drug Combinations; Dysmenorrhea; Female; Human | 1982 |
A comparison of naproxen sodium and a dextropropoxyphene/paracetamol combination in the treatment of primary dysmenorrhoea in University Health Centres.
Topics: Acetaminophen; Adolescent; Adult; Dextropropoxyphene; Drug Combinations; Dysmenorrhea; Female; Human | 1982 |
Antispasmodic/analgesic associations in primary dysmenorrhea double-blind crossover placebo-controlled clinical trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Butylscopolammonium Bromide; Clonixin; Cross-Over St | 2001 |
Acetaminophen does not affect 24-h body temperature or sleep in the luteal phase of the menstrual cycle.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Body Temperature; Dysmenorrhea; Female; Follicular P | 2002 |
Trial of prostaglandin-synthetase inhibitors in primary dysmenorrhoea.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Dextropropoxyphene | 1978 |
Isoxsuprine in primary dysmenorrhoea. Its effectiveness in premenstrual tension.
Topics: Acetaminophen; Adolescent; Adult; Caffeine; Double-Blind Method; Drug Combinations; Dysmenorrhea; Fe | 1975 |
Effect of acetylsalicylic acid, paracetamol, and placebo on pain and blood loss in dysmenorrhoeic women.
Topics: Acetaminophen; Adult; Aspirin; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; | 1978 |
Effect of acetylsalicylic acid, paracetamol and placebo on pain and blood loss in dysmenorrheic women.
Topics: Acetaminophen; Adult; Aspirin; Blood Specimen Collection; Blood Volume; Clinical Trials as Topic; Do | 1979 |
[Use of Mesindol in dysmenorrhea].
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Atropine; Caffeine; Clinical Trials as Topic | 1972 |
Treatment of dysmenorrhea. A comparative double blind study.
Topics: Acetaminophen; Adolescent; Adult; Amphetamine; Analgesics; Aspirin; Barbiturates; Clinical Trials as | 1970 |
[Experiences with the new analgesic Oluprin in gynecologic diseases].
Topics: Acetaminophen; Analgesics; Dysmenorrhea; Endometritis; Female; Genital Diseases, Female; Humans; Par | 1969 |
10 other studies available for acetaminophen and Menstruation, Painful
| Article | Year |
|---|---|
[Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2013 |
[Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2013 |
[Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2013 |
[Comparing efficiencies of diclofenac sodium and paracetamol in patients with primary dysmenorrhea pain by using Visual Analog Scale].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2013 |
Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment.
Topics: Absenteeism; Acetaminophen; Adolescent; Dipyrone; Drug Combinations; Dysmenorrhea; Female; Humans; M | 2010 |
Synergistic relaxing effect of the paracetamol and pyrilamine combination in isolated human myometrium.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Data Interpretation, Statistical; Drug Synergism; Dy | 2011 |
Rett syndrome and menstruation.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Child; Contraceptives, Oral, Hormonal; D | 2012 |
Knowledge and attitudes towards dysmenorrhea among adolescent girls in an urban school in Sri Lanka.
Topics: Acetaminophen; Adolescent; Cross-Sectional Studies; Dysmenorrhea; Female; Health Knowledge, Attitude | 2013 |
Do aspirin and acetaminophen affect total menstrual loss?
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Aspirin; Double-Blind Method; Dysmenorrhea; Female; He | 1984 |
[Gynecologic-obstetric pain therapy. Use of Lonarid N].
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Caffeine; Codeine; Drug Combinations; Dysmenorrhea; E | 1980 |
Drugs for dysmenorrhea.
Topics: Acetaminophen; Aspirin; Dysmenorrhea; Female; Humans; Ibuprofen; Indomethacin; Mefenamic Acid; Nalbu | 1979 |
Menstrual problems in adolescence.
Topics: Acetaminophen; Adolescent; Amenorrhea; Clomiphene; Contraceptives, Oral; Disorders of Sex Developmen | 1975 |
Paracetamol overdose.
Topics: Acetaminophen; Adult; Blood Sedimentation; Cell Migration Inhibition; Dysmenorrhea; Erythema; Female | 1971 |