acetaminophen has been researched along with Malaria in 18 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen inhibits cell-free hemoglobin-induced lipid peroxidation and improves renal function in severe falciparum malaria but has not been evaluated in other infections with prominent hemolysis, including Plasmodium knowlesi malaria." | 9.51 | The Effect of Regularly Dosed Acetaminophen vs No Acetaminophen on Renal Function in Plasmodium knowlesi Malaria (PACKNOW): A Randomized, Controlled Trial. ( Anstey, NM; Barber, BE; Birrell, GW; Cooper, DJ; Dondorp, AM; Edstein, MD; Grigg, MJ; Koleth, G; Menon, J; Patel, A; Piera, KA; Plewes, K; Rajahram, GS; Tarning, J; Wattanakul, T; Wen Yeo, T; William, T, 2022) |
| " The effect of infection with the rodent malaria parasite Plasmodium berghei on the metabolism of phenacetin has been investigated in a rat isolated perfused liver preparation." | 7.69 | Effect of an experimental malaria infection on the metabolism of phenacetin in the rat isolated perfused liver. ( Edwards, G; Glazier, AP; Ismail, S; Kokwaro, GO, 1994) |
| "We have investigated the effect of malaria infection with the rodent parasite Plasmodium berghei and fever induced by Escherichia coli endotoxin on the metabolism of phenacetin to paracetamol by rat liver microsomes from young (4 weeks old) male Wistar rats (N = 5 in control and fever groups; N = 10 in malaria-infected group)." | 7.68 | Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes. ( Breckenridge, AM; Edwards, G; Glazier, AP; Kokwaro, GO; Ward, SA, 1993) |
| "Acetaminophen inhibits cell-free hemoglobin-induced lipid peroxidation and improves renal function in severe falciparum malaria but has not been evaluated in other infections with prominent hemolysis, including Plasmodium knowlesi malaria." | 5.51 | The Effect of Regularly Dosed Acetaminophen vs No Acetaminophen on Renal Function in Plasmodium knowlesi Malaria (PACKNOW): A Randomized, Controlled Trial. ( Anstey, NM; Barber, BE; Birrell, GW; Cooper, DJ; Dondorp, AM; Edstein, MD; Grigg, MJ; Koleth, G; Menon, J; Patel, A; Piera, KA; Plewes, K; Rajahram, GS; Tarning, J; Wattanakul, T; Wen Yeo, T; William, T, 2022) |
| " Their antimalarial effects have been characterized in parasite assays using chloroquine-sensitive and -resistant strains of Plasmodium, alone or in drug combination, and in the Plasmodium berghei rodent model." | 3.74 | Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. ( Becker, K; Davioud-Charvet, E; Friebolin, W; Furrer, J; Jannack, B; Lanzer, M; Oeser, T; Sanchez, CP; Wenzel, N; Yardley, V, 2008) |
| "As an approach to explain the possible in vivo interaction of paracetamol (acetaminophen) with various chloroquine salts that are often administered during malaria tropica, the effects of these salts (chloroquine sulphate, chloroquine phosphate, chloroquine hydrochloride and ferrous sulphate) were examined in male rats." | 3.70 | The contributions of various chloroquine salts to the biliary and urinary execretion of hepatic paracetamol conjugation metabolites in the rat. ( Anyogo, S; Oforah, E, 2000) |
| " The effect of infection with the rodent malaria parasite Plasmodium berghei on the metabolism of phenacetin has been investigated in a rat isolated perfused liver preparation." | 3.69 | Effect of an experimental malaria infection on the metabolism of phenacetin in the rat isolated perfused liver. ( Edwards, G; Glazier, AP; Ismail, S; Kokwaro, GO, 1994) |
| "We have investigated the effect of malaria infection with the rodent parasite Plasmodium berghei and fever induced by Escherichia coli endotoxin on the metabolism of phenacetin to paracetamol by rat liver microsomes from young (4 weeks old) male Wistar rats (N = 5 in control and fever groups; N = 10 in malaria-infected group)." | 3.68 | Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes. ( Breckenridge, AM; Edwards, G; Glazier, AP; Kokwaro, GO; Ward, SA, 1993) |
| "Paracetamol is widely available and has an excellent safety profile; if a renoprotective effect is demonstrated, this trial will support the administration of regularly dosed paracetamol to all patients with knowlesi malaria." | 2.87 | The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW): study protocol for a randomised controlled trial. ( Anstey, NM; Barber, BE; Chatfield, MD; Cooper, DJ; Dondorp, AM; Grigg, MJ; Piera, KA; Plewes, K; Rajahram, GS; William, T; Yeo, TW, 2018) |
| "Sepsis is a heterogeneous clinical syndrome that is complicated commonly by acute kidney injury (sepsis-AKI)." | 2.66 | The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury. ( Kerchberger, VE; Ware, LB, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Friebolin, W | 1 |
| Jannack, B | 1 |
| Wenzel, N | 1 |
| Furrer, J | 1 |
| Oeser, T | 1 |
| Sanchez, CP | 1 |
| Lanzer, M | 1 |
| Yardley, V | 1 |
| Becker, K | 1 |
| Davioud-Charvet, E | 1 |
| Carballeira, NM | 1 |
| Bwalya, AG | 1 |
| Itoe, MA | 1 |
| Andricopulo, AD | 1 |
| Cordero-Maldonado, ML | 1 |
| Kaiser, M | 1 |
| Mota, MM | 1 |
| Crawford, AD | 1 |
| Guido, RV | 1 |
| Tasdemir, D | 1 |
| Cooper, DJ | 2 |
| Grigg, MJ | 2 |
| Plewes, K | 2 |
| Rajahram, GS | 2 |
| Piera, KA | 2 |
| William, T | 2 |
| Menon, J | 1 |
| Koleth, G | 1 |
| Edstein, MD | 1 |
| Birrell, GW | 1 |
| Wattanakul, T | 1 |
| Tarning, J | 1 |
| Patel, A | 1 |
| Wen Yeo, T | 1 |
| Dondorp, AM | 2 |
| Anstey, NM | 2 |
| Barber, BE | 2 |
| Paasi, G | 1 |
| Okalebo, CB | 1 |
| Ongodia, P | 1 |
| Namayanja, C | 1 |
| Eregu, EEI | 1 |
| Abongo, G | 1 |
| Olupot, M | 1 |
| Amorut, D | 1 |
| Muhindo, R | 1 |
| Okiror, W | 1 |
| Ndila, C | 1 |
| Olupot-Olupot, P | 1 |
| Kerchberger, VE | 1 |
| Ware, LB | 1 |
| Chatfield, MD | 1 |
| Yeo, TW | 1 |
| Abrha, S | 1 |
| Tadesse, E | 1 |
| Atey, TM | 1 |
| Molla, F | 1 |
| Melkam, W | 1 |
| Masresha, B | 1 |
| Gashaw, S | 1 |
| Wondimu, A | 1 |
| Ocan, M | 1 |
| Bbosa, GS | 1 |
| Waako, P | 1 |
| Ogwal-Okeng, J | 1 |
| Obua, C | 1 |
| Deharo, E | 1 |
| Barkan, D | 1 |
| Krugliak, M | 1 |
| Golenser, J | 1 |
| Ginsburg, H | 1 |
| Fasan, PO | 1 |
| Mabadeje, AF | 1 |
| Glazier, AP | 2 |
| Kokwaro, GO | 3 |
| Ismail, S | 3 |
| Edwards, G | 5 |
| Back, DJ | 2 |
| Ward, SA | 2 |
| Breckenridge, AM | 1 |
| Agbolosu, NB | 1 |
| Cuevas, LE | 1 |
| Milligan, P | 1 |
| Broadhead, RL | 1 |
| Brewster, D | 1 |
| Graham, SM | 1 |
| Oforah, E | 1 |
| Anyogo, S | 1 |
| Mansor, SM | 1 |
| Roberts, PJ | 1 |
| Ahmed, I | 1 |
| Olowe, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria: A Randomised Controlled Clinical Trial[NCT03056391] | Phase 3 | 360 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for acetaminophen and Malaria
| Article | Year |
|---|---|
The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury.
Topics: Acetaminophen; Acute Kidney Injury; Anemia, Sickle Cell; Animals; Coronary Artery Bypass; Disseminat | 2020 |
5 trials available for acetaminophen and Malaria
| Article | Year |
|---|---|
The Effect of Regularly Dosed Acetaminophen vs No Acetaminophen on Renal Function in Plasmodium knowlesi Malaria (PACKNOW): A Randomized, Controlled Trial.
Topics: Acetaminophen; Acute Kidney Injury; Creatinine; Hemoglobins; Hemolysis; Humans; Kidney; Malaria; Mal | 2022 |
PARIST study protocol: a phase I/II randomised, controlled clinical trial to assess the feasibility, safety and effectiveness of paracetamol in resolving acute kidney injury in children with severe malaria.
Topics: Acetaminophen; Acute Kidney Injury; Child; Clinical Trials, Phase I as Topic; Clinical Trials, Phase | 2023 |
The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW): study protocol for a randomised controlled trial.
Topics: Acetaminophen; Acute Kidney Injury; Antioxidants; Biomarkers; Hemolysis; Humans; Malaria; Malaysia; | 2018 |
A controlled trial of a combination of chloroquine with paracetamol in the treatment of acute malaria in a semi-immune population.
Topics: Acetaminophen; Adolescent; Adult; Child; Chloroquine; Clinical Trials as Topic; Female; Humans; Mala | 1980 |
Efficacy of tepid sponging versus paracetamol in reducing temperature in febrile children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature Regulation; Child, Preschool; Female; Feve | 1997 |
12 other studies available for acetaminophen and Malaria
| Article | Year |
|---|---|
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.
Topics: Animals; Antimalarials; Biological Transport; Cell Line, Tumor; Chloroquine; Drug Resistance; Drug T | 2008 |
2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes.
Topics: Animals; Antimalarials; Cell Line, Tumor; Dose-Response Relationship, Drug; Fatty Acid Synthase, Typ | 2014 |
Availability and affordability of priority life-saving medicines for under-five children in health facilities of Tigray region, northern Ethiopia.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Bacterial Agents; Antimalarials; Antipyretics; Child, Presch | 2018 |
Factors predicting home storage of medicines in Northern Uganda.
Topics: Acetaminophen; Adolescent; Adult; Anti-Infective Agents; Artemether, Lumefantrine Drug Combination; | 2014 |
Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.
Topics: Acetaminophen; Acetylcysteine; Aminoquinolines; Animals; Antimalarials; Chloroquine; Disulfiram; Dru | 2003 |
Effect of an experimental malaria infection on the metabolism of phenacetin in the rat isolated perfused liver.
Topics: Acetaminophen; Animals; Bile; In Vitro Techniques; Liver; Malaria; Male; Models, Biological; Perfusi | 1994 |
Effect of malaria infection on the pharmacokinetics of paracetamol in rat.
Topics: Acetaminophen; Animals; Glucuronates; Malaria; Male; Plasmodium berghei; Rats; Rats, Wistar; Sulfate | 1994 |
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
Topics: Acetaminophen; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Disease Models, Ani | 1993 |
The contributions of various chloroquine salts to the biliary and urinary execretion of hepatic paracetamol conjugation metabolites in the rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antimalarials; Bile; Chloroquine; Drug Interaction | 2000 |
The effect of malaria infection on 3'-azido-3'-deoxythymidine and paracetamol glucuronidation in rat liver microsomes.
Topics: Acetaminophen; Animals; Glucuronates; Glucuronosyltransferase; Isoenzymes; Kinetics; Malaria; Male; | 1992 |
The effect of malaria infection on paracetamol disposition in the rat.
Topics: Acetaminophen; Animals; Bile; Half-Life; Inactivation, Metabolic; Liver; Malaria; Male; Mice; Rats | 1991 |
Haemoglobinuria in Nigerian children.
Topics: Acetaminophen; Aspirin; Autopsy; Brain; Caffeine; Child; Child, Preschool; Coombs Test; Diagnosis, D | 1971 |