acetaminophen has been researched along with Malaria, Falciparum in 22 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Congo is facing frequent failures of treatment of Plasmodium falciparum malaria with chloroquine (CQ), which is still recommended and used as a first-line drug." | 6.71 | Efficacy of sulfadoxine/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Republic of Congo. ( Ebata-Mongo, S; Kiori, J; Le Bras, J; Louya, F; Malanda, M; Malonga, DA; Mouata, AM; Nsimba, B; Oko-Ossho, J; Yocka, D, 2004) |
| " Eligible children will receive treatment allocation randomization either to standard of care for fever management or to prophylactic, scheduled treatment every 6 hours for 72 hours with dual antipyretic therapies using acetaminophen and ibuprofen." | 5.51 | Aggressive antipyretics in central nervous system malaria: Study protocol of a randomized-controlled trial assessing antipyretic efficacy and parasite clearance effects (Malaria FEVER study). ( Birbeck, GL; Chilombe, MB; Mathews, M; McDermott, MP; Mwenechanya, M; Seydel, KB, 2022) |
| "We have previously shown that both chloroquine and paracetamol (acetaminophen) have antipyretic activity during treatment of acute uncomplicated Plasmodium falciparum malaria in children 1-4 years old." | 3.73 | Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes. ( Björkman, A; Hugosson, E; Montgomery, SM; Premji, Z; Troye-Blomberg, M, 2006) |
| "A randomized, open-label, two-treatment, crossover, pharmacokinetic study of paracetamol dosed orally and intramuscularly was conducted." | 2.82 | Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria. ( Chierakul, W; Chotivanich, K; Dondorp, AM; Newton, PN; Plewes, K; Ruengweerayut, R; Silamut, K; Tarning, J; Teerapong, P; Wattanakul, T; White, NJ, 2016) |
| "Congo is facing frequent failures of treatment of Plasmodium falciparum malaria with chloroquine (CQ), which is still recommended and used as a first-line drug." | 2.71 | Efficacy of sulfadoxine/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Republic of Congo. ( Ebata-Mongo, S; Kiori, J; Le Bras, J; Louya, F; Malanda, M; Malonga, DA; Mouata, AM; Nsimba, B; Oko-Ossho, J; Yocka, D, 2004) |
| "Pentoxifylline (POF) may suppress overproduction of tumor necrosis factor alpha (TNF alpha), which is thought to contribute to complications of human falciparum malaria." | 2.68 | Supportive pentoxifylline in falciparum malaria: no effect on tumor necrosis factor alpha levels or clinical outcome: a prospective, randomized, placebo-controlled study. ( Chiwakata, CB; Dietrich, M; Egbring, R; Gaus, W; Hassemer, M; Hemmer, CJ; Hogel, J; Hort, G; Kern, P; Nawroth, PP; Seitz, R, 1997) |
| "falciparum malaria were treated with intravenous quinine and received either mechanical antipyresis alone (electric fanning, tepid sponging, and cool blankets) or in combination with paracetamol." | 2.68 | Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria. ( Brandts, CH; Graninger, W; Kremsner, PG; Ndjavé, M, 1997) |
| "Indomethacin was significantly quicker at clearing fever than acetaminophen (P < 0." | 2.67 | Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria. ( Looareesuwan, S; Wilairatana, P, 1994) |
| "Chloroquine effectiveness was associated with age and ethnicity." | 1.32 | Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso. ( Kouyate, B; Mueller, O; Razum, O; Traore, C, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Chilombe, MB | 1 |
| McDermott, MP | 1 |
| Seydel, KB | 1 |
| Mathews, M | 1 |
| Mwenechanya, M | 1 |
| Birbeck, GL | 1 |
| Paasi, G | 1 |
| Okalebo, CB | 1 |
| Ongodia, P | 1 |
| Namayanja, C | 1 |
| Eregu, EEI | 1 |
| Abongo, G | 1 |
| Olupot, M | 1 |
| Amorut, D | 1 |
| Muhindo, R | 1 |
| Okiror, W | 1 |
| Ndila, C | 1 |
| Olupot-Olupot, P | 1 |
| Plewes, K | 3 |
| Turner, GDH | 2 |
| Dondorp, AM | 3 |
| Kingston, HWF | 1 |
| Ghose, A | 1 |
| Wattanakul, T | 2 |
| Hassan, MMU | 1 |
| Haider, MS | 1 |
| Dutta, PK | 1 |
| Islam, MA | 1 |
| Alam, S | 1 |
| Jahangir, SM | 1 |
| Zahed, ASM | 1 |
| Sattar, MA | 1 |
| Chowdhury, MAH | 1 |
| Herdman, MT | 1 |
| Leopold, SJ | 1 |
| Ishioka, H | 1 |
| Piera, KA | 1 |
| Charunwatthana, P | 1 |
| Silamut, K | 2 |
| Yeo, TW | 1 |
| Lee, SJ | 1 |
| Mukaka, M | 1 |
| Maude, RJ | 1 |
| Faiz, MA | 1 |
| Tarning, J | 2 |
| Oates, JA | 1 |
| Anstey, NM | 1 |
| White, NJ | 2 |
| Day, NPJ | 1 |
| Hossain, MA | 1 |
| Roberts Ii, LJ | 1 |
| Teerapong, P | 1 |
| Newton, PN | 1 |
| Chierakul, W | 1 |
| Chotivanich, K | 1 |
| Ruengweerayut, R | 1 |
| Kofoed, PE | 1 |
| Ursing, J | 1 |
| Rodrigues, A | 1 |
| Rombo, L | 2 |
| Hugosson, E | 2 |
| Tarimo, D | 1 |
| Troye-Blomberg, M | 2 |
| Montgomery, SM | 2 |
| Premji, Z | 2 |
| Björkman, A | 2 |
| Nsimba, B | 1 |
| Malonga, DA | 1 |
| Mouata, AM | 1 |
| Louya, F | 1 |
| Kiori, J | 1 |
| Malanda, M | 1 |
| Yocka, D | 1 |
| Oko-Ossho, J | 1 |
| Ebata-Mongo, S | 1 |
| Le Bras, J | 1 |
| Perch, M | 1 |
| Kofoed, P | 1 |
| Fischer, TK | 1 |
| Có, F | 1 |
| Aaby, P | 1 |
| Eugen-Olsen, J | 1 |
| Mueller, O | 1 |
| Razum, O | 1 |
| Traore, C | 1 |
| Kouyate, B | 1 |
| Ismail, S | 1 |
| Na Bangchang, K | 1 |
| Karbwang, J | 1 |
| Back, DJ | 1 |
| Edwards, G | 1 |
| Wilairatana, P | 2 |
| Looareesuwan, S | 2 |
| Kaojarern, S | 1 |
| Vanijanonta, S | 1 |
| Charoenlarp, P | 1 |
| Berclaz, PY | 1 |
| Benedek, C | 1 |
| Jequier, E | 1 |
| Schutz, Y | 1 |
| Hemmer, CJ | 1 |
| Hort, G | 1 |
| Chiwakata, CB | 1 |
| Seitz, R | 1 |
| Egbring, R | 1 |
| Gaus, W | 1 |
| Hogel, J | 1 |
| Hassemer, M | 1 |
| Nawroth, PP | 1 |
| Kern, P | 1 |
| Dietrich, M | 1 |
| Brandts, CH | 1 |
| Ndjavé, M | 1 |
| Graninger, W | 1 |
| Kremsner, PG | 1 |
| Kazembe, PN | 1 |
| Anderson, BJ | 1 |
| Monteleone, J | 1 |
| Holford, NH | 1 |
| Robert, V | 1 |
| Awono-Ambene, HP | 1 |
| Le Hesran, JY | 1 |
| Trape, JF | 1 |
| Yeboah-Antwi, K | 1 |
| Gyapong, JO | 1 |
| Asare, IK | 1 |
| Barnish, G | 1 |
| Evans, DB | 1 |
| Adjei, S | 1 |
| Tarimo, DS | 1 |
| Minjas, JN | 1 |
| Bygbjerg, IC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819] | 256 participants (Anticipated) | Observational | 2021-01-02 | Enrolling by invitation | |||
| Paracetamol Effect on Oxidative Stress and Renal Function in Severe Falciparum Malaria With Intravascular Haemolysis: A Randomised Controlled Clinical Trial[NCT01641289] | 62 participants (Actual) | Interventional | 2012-07-10 | Completed | |||
| The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau[NCT00137566] | Phase 4 | 0 participants | Interventional | 2004-05-31 | Active, not recruiting | ||
| Randomised, Double-Blind, Placebo Controlled Study of the Antipyretic Effect of Ibuprofen in Children With Uncomplicated Malaria[NCT00167713] | Phase 4 | 50 participants | Interventional | 2003-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for acetaminophen and Malaria, Falciparum
| Article | Year |
|---|---|
Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Coma; De | 2018 |
13 trials available for acetaminophen and Malaria, Falciparum
| Article | Year |
|---|---|
Aggressive antipyretics in central nervous system malaria: Study protocol of a randomized-controlled trial assessing antipyretic efficacy and parasite clearance effects (Malaria FEVER study).
Topics: Acetaminophen; Animals; Antipyretics; Central Nervous System; Child; Fever; Histidine; Humans; Ibupr | 2022 |
PARIST study protocol: a phase I/II randomised, controlled clinical trial to assess the feasibility, safety and effectiveness of paracetamol in resolving acute kidney injury in children with severe malaria.
Topics: Acetaminophen; Acute Kidney Injury; Child; Clinical Trials, Phase I as Topic; Clinical Trials, Phase | 2023 |
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area | 2018 |
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area | 2018 |
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area | 2018 |
Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Antimalarials; Area | 2018 |
Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Antimalarials; Antipyretics; Biological Avai | 2016 |
Paracetamol versus placebo in treatment of non-severe malaria in children in Guinea-Bissau: a randomized controlled trial.
Topics: Acetaminophen; Adolescent; Antipyretics; Body Temperature; Child; Child, Preschool; Female; Fever; G | 2011 |
Antipyretic, parasitologic, and immunologic effects of combining sulfadoxine/pyrimethamine with chloroquine or paracetamol for treating uncomplicated Plasmodium falciparum malaria.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antimalarials; Body Temperature; Child, Preschool; | 2003 |
Efficacy of sulfadoxine/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Republic of Congo.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antimalarials; Child, Preschool; Congo; Drug Combinations; | 2004 |
Paracetamol disposition in Thai patients during and after treatment of falciparum malaria.
Topics: Acetaminophen; Adult; Biotransformation; Half-Life; Humans; Malaria, Falciparum; Male | 1995 |
Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Female; Fever; Humans; Indomethacin; Malaria | 1994 |
Supportive pentoxifylline in falciparum malaria: no effect on tumor necrosis factor alpha levels or clinical outcome: a prospective, randomized, placebo-controlled study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Antimalarials; Biopterins; Drug Therapy, Combi | 1997 |
Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Child; Child, Preschool; Female; Fever; Humans; In | 1997 |
Impact of prepackaging antimalarial drugs on cost to patients and compliance with treatment.
Topics: Acetaminophen; Adult; Antimalarials; Child; Chloroquine; Dosage Forms; Drug Costs; Drug Packaging; G | 2001 |
Sulfadoxine-pyrimethamine monotherapy in Tanzanian children gives rapid parasite clearance but slow fever clearance that is improved by chloroquine in combination therapy.
Topics: Acetaminophen; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Dru | 2002 |
8 other studies available for acetaminophen and Malaria, Falciparum
| Article | Year |
|---|---|
Serum levels of soluble urokinase plasminogen activator receptor is associated with parasitemia in children with acute Plasmodium falciparum malaria infection.
Topics: Acetaminophen; Acute Disease; Amoxicillin; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; | 2004 |
Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antimalarials; Burkina Faso; Caregivers; Child, Preschool; | 2004 |
Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antimalarials; Child, Preschool; Chloroquine; Cyto | 2006 |
Gastric emptying in acute uncomplicated falciparum malaria.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Convalescence; Gastric Emptying; Humans; Intestinal | 1995 |
Changes in protein turnover and resting energy expenditure after treatment of malaria in Gambian children.
Topics: Acetaminophen; Adolescent; Body Mass Index; Body Temperature; Body Weight; Child; Chloroquine; Energ | 1996 |
Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antimalarials; Child; Cross Infection; Ethics, Medical; Hum | 1997 |
Variability of concentrations after rectal paracetamol.
Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Adult; Analgesics, Non-Narcotic; Child; | 1998 |
Gametocytemia and infectivity to mosquitoes of patients with uncomplicated Plasmodium falciparum malaria attacks treated with chloroquine or sulfadoxine plus pyrimethamine.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Animals; Anopheles; Antimalarials; Child | 2000 |