Page last updated: 2024-10-22

acetaminophen and MODS

acetaminophen has been researched along with MODS in 30 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
"The systemic inflammatory response syndrome (SIRS) and sequential organ failure assessment (SOFA) scores are widely used as prognostic markers in critical care settings and could improve triage of high-risk paracetamol (acetaminophen) overdose patients."7.77The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose. ( Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Reid, TW; Simpson, KJ, 2011)
"Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure."7.73Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006)
"Admission M30 levels were significantly elevated in acetaminophen-induced acute liver failure and non-acetaminophen induced acute liver failure patients compared with multiple organ failure, chronic liver disease, and healthy controls."3.79Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*. ( Abeles, RD; Antoniades, CG; Bernal, W; Dharwan, A; Heaton, ND; Hughes, RD; Jassem, W; Karvellas, CJ; Leslie, EM; Ma, Y; McPhail, MJ; Mitry, RR; Possamai, LA; Puthucheary, Z; Quaglia, A; Rawal, J; Shawcross, DL; Thursz, M; Tidswell, R; Wendon, JA; Zingarelli, V, 2013)
"The systemic inflammatory response syndrome (SIRS) and sequential organ failure assessment (SOFA) scores are widely used as prognostic markers in critical care settings and could improve triage of high-risk paracetamol (acetaminophen) overdose patients."3.77The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose. ( Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Reid, TW; Simpson, KJ, 2011)
"Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure."3.73Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006)
"High levels of tumor necrosis factor-alpha are associated with an increased risk of severe encephalopathy in acute liver failure, and experimental studies suggest that tumor necrosis factor-alpha plays a role in the development of acetaminophen (paracetamol)-induced liver injury and associated multiple organ failure."3.70Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. ( Bernal, W; Donaldson, P; Underhill, J; Wendon, J; Williams, R, 1998)
"Death commonly involved multiple substance use and abuse behaviours indicative of misuse and dependence."1.48Unintentional mortality associated with paracetamol and codeine preparations, with and without doxylamine, in Australia. ( Dobbin, M; Hopkins, RE; Pilgrim, JL, 2018)
"Irreversible acute liver failure, defined as rise in prothrombin time >3 times normal, occurred 19."1.39A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival. ( Alibhai, H; Baker, LA; Chang, YM; Davies, NA; Jalan, R; L Priestnall, S; Leckie, PJ; Lee, KC; Mookerjee, RP; Palacios Jimenez, C; Stanzani, G, 2013)
"Both delayed presentation and staggered overdose pattern are associated with adverse outcomes following paracetamol overdose."1.38Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity. ( Bates, CM; Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Simpson, KJ, 2012)
"Acetaminophen-induced acute liver failure (ALF) is a complex multiorgan illness."1.38Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure. ( Agarwal, B; Betrosian, A; Burroughs, AK; Cholongitas, E; O'Beirne, J; Patch, D; Shaw, S; Theocharidou, E; Vasianopoulou, P, 2012)
" Physicians should be aware of potential hepatotoxicity and nephrotoxicity of acetaminophen, even if given at therapeutic dosage in acute febrile illness."1.34Therapeutic dose of acetaminophen with fatal hepatic necrosis and acute renal failure. ( Lohachit, P; Ruamvang, T; Satirapoj, B, 2007)
"Paracetamol-induced acute liver failure is associated with increases in the CO2 gap and decreases in pHi between 4 to 9 days post-paracetamol ingestion."1.31A prospective study of gastric mucosal ischaemia in paracetamol-induced acute liver failure. ( Gabe, SM; Rhodes, A; Wendon, JA, 2000)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.33)18.7374
1990's3 (10.00)18.2507
2000's6 (20.00)29.6817
2010's17 (56.67)24.3611
2020's3 (10.00)2.80

Authors

AuthorsStudies
Dong, V1
Nanchal, R1
Karvellas, CJ3
Speiser, JL1
Tremblay, M1
Lee, WM1
Rose, CF1
Cavazza, A1
McPhail, MJ2
Hopkins, RE1
Dobbin, M1
Pilgrim, JL1
Shah, N1
Montes de Oca, M1
Jover-Cobos, M1
Tanamoto, K1
Muroi, M1
Sugiyama, K1
Davies, NA2
Mookerjee, RP2
Dhar, DK1
Jalan, R2
Moore, JK1
Craig, DG6
Pryde, EA1
Walker, SW1
Beckett, GJ1
Hayes, PC5
Simpson, KJ6
Possamai, LA1
Quaglia, A1
Zingarelli, V1
Abeles, RD1
Tidswell, R1
Puthucheary, Z1
Rawal, J1
Leslie, EM1
Hughes, RD1
Ma, Y1
Jassem, W1
Shawcross, DL1
Bernal, W2
Dharwan, A1
Heaton, ND1
Thursz, M1
Wendon, JA3
Mitry, RR1
Antoniades, CG1
Cullis, PS1
Watson, D1
Cameron, A1
McKee, RF1
Hadzik, B1
Grass, H1
Mayatepek, E1
Daldrup, T1
Hoehn, T1
Reid, TW2
Martin, KG3
Davidson, JS3
Hydzik, P1
Gawlikowski, T1
Groszek, B1
Bates, CM1
Cholongitas, E1
Theocharidou, E1
Vasianopoulou, P1
Betrosian, A1
Shaw, S1
Patch, D1
O'Beirne, J1
Agarwal, B1
Burroughs, AK1
Voigt, MD1
Zafar, S1
Reiter, C1
Elsharkawy, AM1
Mutimer, DJ1
Lee, KC1
Palacios Jimenez, C1
Alibhai, H1
Chang, YM1
Leckie, PJ1
Baker, LA1
Stanzani, G1
L Priestnall, S1
Schmidt, LE1
Larsen, FS2
Bourdeaux, C1
Bewley, J1
Satirapoj, B1
Lohachit, P1
Ruamvang, T1
Evans, PJ1
Evans, RW1
Bomford, A1
Williams, R2
Halliwell, B1
Kirkegaard, P1
Rasmussen, A1
Hansen, BA1
Donaldson, P1
Underhill, J1
Wendon, J1
Rhodes, A1
Gabe, SM1
Clark, SJ1
Shojaee-Moradie, F1
Croos, P1
Seed, PT1
Umpleby, AM1
Miell, J1
Köster, M1
Wege, T1
Ganzemüller, C1
Lengfelder, W1
Fudin, R1
Prego, J1
Schwartz, M1
Shostak, A1
Jaichenko, J1
Gotloib, L1

Reviews

2 reviews available for acetaminophen and MODS

ArticleYear
Pathophysiology of Acute Liver Failure.
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2020, Volume: 35, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema

2020
Dipyridamole and paracetamol overdose resulting in multi-organ failure.
    Scottish medical journal, 2013, Volume: 58, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Depression; Dipyridamole; Drug Overdose; Female; Hospitaliz

2013

Other Studies

28 other studies available for acetaminophen and MODS

ArticleYear
Elevated Serum Liver-Type Fatty Acid Binding Protein Levels in Non-acetaminophen Acute Liver Failure Patients with Organ Dysfunction.
    Digestive diseases and sciences, 2021, Volume: 66, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Biomarkers; Case-Control Studies; Fatty Acid-Binding

2021
Absolutely FABulous? FABP-1 in Non-acetaminophen-related Acute Liver Failure.
    Digestive diseases and sciences, 2021, Volume: 66, Issue:1

    Topics: Acetaminophen; Fatty Acid-Binding Proteins; Humans; Liver Failure, Acute; Multiple Organ Failure

2021
Unintentional mortality associated with paracetamol and codeine preparations, with and without doxylamine, in Australia.
    Forensic science international, 2018, Volume: 282

    Topics: Accidents; Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Antiemetics; Austr

2018
Role of toll-like receptor 4 in mediating multiorgan dysfunction in mice with acetaminophen induced acute liver failure.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2013, Volume: 19, Issue:7

    Topics: Acetaminophen; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Cytokines; D

2013
Persistently elevated troponin I in paracetamol hepatotoxicity: association with liver injury, organ failure, and outcome.
    Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:7

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; APACHE; Biomarkers; Chemical and D

2013
Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*.
    Critical care medicine, 2013, Volume: 41, Issue:11

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; APACHE; Apoptosis; Chemical and Drug Induced L

2013
Fatal non-accidental alpha-lipoic acid intoxication in an adolescent girl.
    Klinische Padiatrie, 2014, Volume: 226, Issue:5

    Topics: Acetaminophen; Adolescent; Anti-Obesity Agents; Antioxidants; Critical Care; Drug Overdose; Fatal Ou

2014
The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose.
    Alimentary pharmacology & therapeutics, 2011, Volume: 34, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Liver Failure, Acute;

2011
[Drug-induced erythrodermia complicated by multiorgan failure--case report].
    Przeglad lekarski, 2011, Volume: 68, Issue:8

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clarithromycin; Dermatitis, Exfoliati

2011
Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity.
    British journal of clinical pharmacology, 2012, Volume: 73, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studi

2012
Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2012, Volume: 18, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Biomarkers; Chemical and Drug Induced Liver

2012
Predicting death in patients with acetaminophen-induced acute liver failure: the King's College Hospital model is on the SOFA, not the mat.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2012, Volume: 18, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Health Stat

2012
SOFA score and acetaminophen-induced acute liver failure.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2012, Volume: 18, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Health Stat

2012
The sequential organ failure assessment (SOFA) score is an effective triage marker following staggered paracetamol (acetaminophen) overdose.
    Alimentary pharmacology & therapeutics, 2012, Volume: 35, Issue:12

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Chemical and Drug Induced Liver Injury; Drug

2012
RE: Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity.
    British journal of clinical pharmacology, 2013, Volume: 75, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema

2013
Authors' response to Dr Reiter.
    British journal of clinical pharmacology, 2013, Volume: 75, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema

2013
Commentary: SOFA scores and staggered paracetamol overdose prognostication.
    Alimentary pharmacology & therapeutics, 2012, Volume: 36, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; APACHE; Chemical and Drug Induced Liver Injury; Female; Hum

2012
A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival.
    Liver international : official journal of the International Association for the Study of the Liver, 2013, Volume: 33, Issue:4

    Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Animals; Biomarkers; Cardiovascular Diseases; Chemic

2013
Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure.
    Critical care medicine, 2006, Volume: 34, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Female; Hepatic Encephalopa

2006
Death from paracetamol overdose despite appropriate treatment with N-acetylcysteine.
    Emergency medicine journal : EMJ, 2007, Volume: 24, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Fatal Outcome; Free Radical

2007
Therapeutic dose of acetaminophen with fatal hepatic necrosis and acute renal failure.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Autopsy; Fatal Outcome; Female;

2007
Metal ions catalytic for free radical reactions in the plasma of patients with fulminant hepatic failure.
    Free radical research, 1994, Volume: 20, Issue:3

    Topics: Acetaminophen; Adult; Aged; Antioxidants; Chelating Agents; Copper; Female; Free Radicals; Hepatic E

1994
The Danish liver transplantation program and patients with serious acetaminophen intoxication.
    Transplantation proceedings, 1995, Volume: 27, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Aged; Child; Denmark; Drug Overdose; Female; Hepatic Encephalopath

1995
Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.
    Journal of hepatology, 1998, Volume: 29, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Alleles; Analgesics, Non-Narcotic; APACHE; Chemical and Drug Induc

1998
A prospective study of gastric mucosal ischaemia in paracetamol-induced acute liver failure.
    Intensive care medicine, 2000, Volume: 26, Issue:9

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Carbon Dioxide; Female;

2000
Temporal changes in insulin sensitivity following the development of acute liver failure secondary to acetaminophen.
    Hepatology (Baltimore, Md.), 2001, Volume: 34, Issue:1

    Topics: Acetaminophen; Adult; Blood Glucose; C-Peptide; Fatal Outcome; Fatty Acids, Nonesterified; Female; G

2001
[44-year-old patient with thrombocytopenia, multiple organ failure and disseminated intravascular coagulation caused by drug poisoning with paracetamol, metamizole, benzodiazepines and alcohol in attempted suicide].
    Der Internist, 2001, Volume: 42, Issue:6

    Topics: Acetaminophen; Adult; Alcoholic Intoxication; Bromazepam; Critical Care; Dipyrone; Disseminated Intr

2001
Sequential hemofiltration in MOF associated with paracetamol intoxication and gram-negative sepsis.
    Intensive care medicine, 1989, Volume: 15, Issue:5

    Topics: Acetaminophen; Child; Hemofiltration; Humans; Klebsiella Infections; Male; Multiple Organ Failure; S

1989