acetaminophen has been researched along with MODS in 30 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The systemic inflammatory response syndrome (SIRS) and sequential organ failure assessment (SOFA) scores are widely used as prognostic markers in critical care settings and could improve triage of high-risk paracetamol (acetaminophen) overdose patients." | 7.77 | The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose. ( Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Reid, TW; Simpson, KJ, 2011) |
| "Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure." | 7.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "Admission M30 levels were significantly elevated in acetaminophen-induced acute liver failure and non-acetaminophen induced acute liver failure patients compared with multiple organ failure, chronic liver disease, and healthy controls." | 3.79 | Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*. ( Abeles, RD; Antoniades, CG; Bernal, W; Dharwan, A; Heaton, ND; Hughes, RD; Jassem, W; Karvellas, CJ; Leslie, EM; Ma, Y; McPhail, MJ; Mitry, RR; Possamai, LA; Puthucheary, Z; Quaglia, A; Rawal, J; Shawcross, DL; Thursz, M; Tidswell, R; Wendon, JA; Zingarelli, V, 2013) |
| "The systemic inflammatory response syndrome (SIRS) and sequential organ failure assessment (SOFA) scores are widely used as prognostic markers in critical care settings and could improve triage of high-risk paracetamol (acetaminophen) overdose patients." | 3.77 | The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose. ( Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Reid, TW; Simpson, KJ, 2011) |
| "Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure." | 3.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "High levels of tumor necrosis factor-alpha are associated with an increased risk of severe encephalopathy in acute liver failure, and experimental studies suggest that tumor necrosis factor-alpha plays a role in the development of acetaminophen (paracetamol)-induced liver injury and associated multiple organ failure." | 3.70 | Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. ( Bernal, W; Donaldson, P; Underhill, J; Wendon, J; Williams, R, 1998) |
| "Death commonly involved multiple substance use and abuse behaviours indicative of misuse and dependence." | 1.48 | Unintentional mortality associated with paracetamol and codeine preparations, with and without doxylamine, in Australia. ( Dobbin, M; Hopkins, RE; Pilgrim, JL, 2018) |
| "Irreversible acute liver failure, defined as rise in prothrombin time >3 times normal, occurred 19." | 1.39 | A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival. ( Alibhai, H; Baker, LA; Chang, YM; Davies, NA; Jalan, R; L Priestnall, S; Leckie, PJ; Lee, KC; Mookerjee, RP; Palacios Jimenez, C; Stanzani, G, 2013) |
| "Both delayed presentation and staggered overdose pattern are associated with adverse outcomes following paracetamol overdose." | 1.38 | Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity. ( Bates, CM; Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Simpson, KJ, 2012) |
| "Acetaminophen-induced acute liver failure (ALF) is a complex multiorgan illness." | 1.38 | Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure. ( Agarwal, B; Betrosian, A; Burroughs, AK; Cholongitas, E; O'Beirne, J; Patch, D; Shaw, S; Theocharidou, E; Vasianopoulou, P, 2012) |
| " Physicians should be aware of potential hepatotoxicity and nephrotoxicity of acetaminophen, even if given at therapeutic dosage in acute febrile illness." | 1.34 | Therapeutic dose of acetaminophen with fatal hepatic necrosis and acute renal failure. ( Lohachit, P; Ruamvang, T; Satirapoj, B, 2007) |
| "Paracetamol-induced acute liver failure is associated with increases in the CO2 gap and decreases in pHi between 4 to 9 days post-paracetamol ingestion." | 1.31 | A prospective study of gastric mucosal ischaemia in paracetamol-induced acute liver failure. ( Gabe, SM; Rhodes, A; Wendon, JA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 17 (56.67) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, V | 1 |
| Nanchal, R | 1 |
| Karvellas, CJ | 3 |
| Speiser, JL | 1 |
| Tremblay, M | 1 |
| Lee, WM | 1 |
| Rose, CF | 1 |
| Cavazza, A | 1 |
| McPhail, MJ | 2 |
| Hopkins, RE | 1 |
| Dobbin, M | 1 |
| Pilgrim, JL | 1 |
| Shah, N | 1 |
| Montes de Oca, M | 1 |
| Jover-Cobos, M | 1 |
| Tanamoto, K | 1 |
| Muroi, M | 1 |
| Sugiyama, K | 1 |
| Davies, NA | 2 |
| Mookerjee, RP | 2 |
| Dhar, DK | 1 |
| Jalan, R | 2 |
| Moore, JK | 1 |
| Craig, DG | 6 |
| Pryde, EA | 1 |
| Walker, SW | 1 |
| Beckett, GJ | 1 |
| Hayes, PC | 5 |
| Simpson, KJ | 6 |
| Possamai, LA | 1 |
| Quaglia, A | 1 |
| Zingarelli, V | 1 |
| Abeles, RD | 1 |
| Tidswell, R | 1 |
| Puthucheary, Z | 1 |
| Rawal, J | 1 |
| Leslie, EM | 1 |
| Hughes, RD | 1 |
| Ma, Y | 1 |
| Jassem, W | 1 |
| Shawcross, DL | 1 |
| Bernal, W | 2 |
| Dharwan, A | 1 |
| Heaton, ND | 1 |
| Thursz, M | 1 |
| Wendon, JA | 3 |
| Mitry, RR | 1 |
| Antoniades, CG | 1 |
| Cullis, PS | 1 |
| Watson, D | 1 |
| Cameron, A | 1 |
| McKee, RF | 1 |
| Hadzik, B | 1 |
| Grass, H | 1 |
| Mayatepek, E | 1 |
| Daldrup, T | 1 |
| Hoehn, T | 1 |
| Reid, TW | 2 |
| Martin, KG | 3 |
| Davidson, JS | 3 |
| Hydzik, P | 1 |
| Gawlikowski, T | 1 |
| Groszek, B | 1 |
| Bates, CM | 1 |
| Cholongitas, E | 1 |
| Theocharidou, E | 1 |
| Vasianopoulou, P | 1 |
| Betrosian, A | 1 |
| Shaw, S | 1 |
| Patch, D | 1 |
| O'Beirne, J | 1 |
| Agarwal, B | 1 |
| Burroughs, AK | 1 |
| Voigt, MD | 1 |
| Zafar, S | 1 |
| Reiter, C | 1 |
| Elsharkawy, AM | 1 |
| Mutimer, DJ | 1 |
| Lee, KC | 1 |
| Palacios Jimenez, C | 1 |
| Alibhai, H | 1 |
| Chang, YM | 1 |
| Leckie, PJ | 1 |
| Baker, LA | 1 |
| Stanzani, G | 1 |
| L Priestnall, S | 1 |
| Schmidt, LE | 1 |
| Larsen, FS | 2 |
| Bourdeaux, C | 1 |
| Bewley, J | 1 |
| Satirapoj, B | 1 |
| Lohachit, P | 1 |
| Ruamvang, T | 1 |
| Evans, PJ | 1 |
| Evans, RW | 1 |
| Bomford, A | 1 |
| Williams, R | 2 |
| Halliwell, B | 1 |
| Kirkegaard, P | 1 |
| Rasmussen, A | 1 |
| Hansen, BA | 1 |
| Donaldson, P | 1 |
| Underhill, J | 1 |
| Wendon, J | 1 |
| Rhodes, A | 1 |
| Gabe, SM | 1 |
| Clark, SJ | 1 |
| Shojaee-Moradie, F | 1 |
| Croos, P | 1 |
| Seed, PT | 1 |
| Umpleby, AM | 1 |
| Miell, J | 1 |
| Köster, M | 1 |
| Wege, T | 1 |
| Ganzemüller, C | 1 |
| Lengfelder, W | 1 |
| Fudin, R | 1 |
| Prego, J | 1 |
| Schwartz, M | 1 |
| Shostak, A | 1 |
| Jaichenko, J | 1 |
| Gotloib, L | 1 |
2 reviews available for acetaminophen and MODS
| Article | Year |
|---|---|
Pathophysiology of Acute Liver Failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2020 |
Dipyridamole and paracetamol overdose resulting in multi-organ failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Depression; Dipyridamole; Drug Overdose; Female; Hospitaliz | 2013 |
28 other studies available for acetaminophen and MODS
| Article | Year |
|---|---|
Elevated Serum Liver-Type Fatty Acid Binding Protein Levels in Non-acetaminophen Acute Liver Failure Patients with Organ Dysfunction.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Biomarkers; Case-Control Studies; Fatty Acid-Binding | 2021 |
Absolutely FABulous? FABP-1 in Non-acetaminophen-related Acute Liver Failure.
Topics: Acetaminophen; Fatty Acid-Binding Proteins; Humans; Liver Failure, Acute; Multiple Organ Failure | 2021 |
Unintentional mortality associated with paracetamol and codeine preparations, with and without doxylamine, in Australia.
Topics: Accidents; Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Antiemetics; Austr | 2018 |
Role of toll-like receptor 4 in mediating multiorgan dysfunction in mice with acetaminophen induced acute liver failure.
Topics: Acetaminophen; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Cytokines; D | 2013 |
Persistently elevated troponin I in paracetamol hepatotoxicity: association with liver injury, organ failure, and outcome.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; APACHE; Biomarkers; Chemical and D | 2013 |
Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; APACHE; Apoptosis; Chemical and Drug Induced L | 2013 |
Fatal non-accidental alpha-lipoic acid intoxication in an adolescent girl.
Topics: Acetaminophen; Adolescent; Anti-Obesity Agents; Antioxidants; Critical Care; Drug Overdose; Fatal Ou | 2014 |
The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Liver Failure, Acute; | 2011 |
[Drug-induced erythrodermia complicated by multiorgan failure--case report].
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clarithromycin; Dermatitis, Exfoliati | 2011 |
Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studi | 2012 |
Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Biomarkers; Chemical and Drug Induced Liver | 2012 |
Predicting death in patients with acetaminophen-induced acute liver failure: the King's College Hospital model is on the SOFA, not the mat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Health Stat | 2012 |
SOFA score and acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Health Stat | 2012 |
The sequential organ failure assessment (SOFA) score is an effective triage marker following staggered paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Chemical and Drug Induced Liver Injury; Drug | 2012 |
RE: Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2013 |
Authors' response to Dr Reiter.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fema | 2013 |
Commentary: SOFA scores and staggered paracetamol overdose prognostication.
Topics: Acetaminophen; Analgesics, Non-Narcotic; APACHE; Chemical and Drug Induced Liver Injury; Female; Hum | 2012 |
A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Animals; Biomarkers; Cardiovascular Diseases; Chemic | 2013 |
Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Female; Hepatic Encephalopa | 2006 |
Death from paracetamol overdose despite appropriate treatment with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Fatal Outcome; Free Radical | 2007 |
Therapeutic dose of acetaminophen with fatal hepatic necrosis and acute renal failure.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Autopsy; Fatal Outcome; Female; | 2007 |
Metal ions catalytic for free radical reactions in the plasma of patients with fulminant hepatic failure.
Topics: Acetaminophen; Adult; Aged; Antioxidants; Chelating Agents; Copper; Female; Free Radicals; Hepatic E | 1994 |
The Danish liver transplantation program and patients with serious acetaminophen intoxication.
Topics: Acetaminophen; Adolescent; Adult; Aged; Child; Denmark; Drug Overdose; Female; Hepatic Encephalopath | 1995 |
Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Alleles; Analgesics, Non-Narcotic; APACHE; Chemical and Drug Induc | 1998 |
A prospective study of gastric mucosal ischaemia in paracetamol-induced acute liver failure.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Carbon Dioxide; Female; | 2000 |
Temporal changes in insulin sensitivity following the development of acute liver failure secondary to acetaminophen.
Topics: Acetaminophen; Adult; Blood Glucose; C-Peptide; Fatal Outcome; Fatty Acids, Nonesterified; Female; G | 2001 |
[44-year-old patient with thrombocytopenia, multiple organ failure and disseminated intravascular coagulation caused by drug poisoning with paracetamol, metamizole, benzodiazepines and alcohol in attempted suicide].
Topics: Acetaminophen; Adult; Alcoholic Intoxication; Bromazepam; Critical Care; Dipyrone; Disseminated Intr | 2001 |
Sequential hemofiltration in MOF associated with paracetamol intoxication and gram-negative sepsis.
Topics: Acetaminophen; Child; Hemofiltration; Humans; Klebsiella Infections; Male; Multiple Organ Failure; S | 1989 |