acetaminophen has been researched along with Low Back Pain in 122 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Low Back Pain: Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " 210 eligible patients without trauma who presented with low back pain were recruited for the study and randomized into paracetamol (n = 71), dexketoprofen (n = 70), and ibuprofen (n = 69) groups." | 9.51 | Comparative evaluation of the effectiveness of intravenous paracetamol, dexketoprofen and ibuprofen in acute low back pain. ( Dogan, C; Kemanci, A; Oskay, A; Ozen, M; Seyit, M; Turkcuer, I; Uluturk, M; Yilmaz, A, 2022) |
| "To assess the analgesic efficacy and safety of single-dose oral cannabidiol (CBD) as an adjunct to standard care for patients presenting to an emergency department with acute low back pain." | 9.41 | The CANBACK trial: a randomised, controlled clinical trial of oral cannabidiol for people presenting to the emergency department with acute low back pain. ( Bebee, B; Bourke, E; Ching, M; Foster, L; Pollack, K; Taylor, DM; Wong, A, 2021) |
| "Current worldwide clinical practice guidelines recommend acetaminophen as the first option for the treatment of acute low back pain." | 9.27 | Randomized open-label [corrected] non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain. ( Arai, YC; Hayashi, K; Ikemoto, T; Miki, K; Sekiguchi, M; Shi, K; Ushida, T, 2018) |
| "This paper presents the design of the PACE Plus trial: a multi-center, placebo-blinded, superiority randomized controlled trial in primary care that will assess the effectiveness of advice only, paracetamol, diclofenac and placebo for acute low back pain." | 9.24 | Efficacy of paracetamol, diclofenac and advice for acute low back pain in general practice: design of a randomized controlled trial (PACE Plus). ( Koes, BW; Koopmanschap, MA; Luijsterburg, PA; Maher, CG; Rizopoulos, D; Schreijenberg, M; Van Trier, YD; Voogt, L, 2017) |
| "In this randomized controlled trial, we compared the effect of celecoxib and acetaminophen on pain and magnetic resonance imaging (MRI) scores in patients with chronic nonspecific low back pain." | 9.22 | Clinical Efficacy of Celecoxib Compared to Acetaminophen in Chronic Nonspecific Low Back Pain: Results of a Randomized Controlled Trial. ( Bedaiwi, MK; Haroon, N; Inman, RD; O'shea, FD; Omar, A; Salonen, D; Sari, I; Wallis, D, 2016) |
| "Clinical Question Does the addition of cyclobenzaprine or oxycodone with acetaminophen to naproxen result in improved functional outcomes at one week when compared to placebo in patients with acute low back pain? Article Chosen Friedman B, Dym A, Davitt, M, et al." | 9.22 | Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain. ( Gottlieb, M; Njie, A, 2016) |
| "This investigation found that tramadol-acetaminophen is effective for reducing LBP and provided a prophylactic antidepressant effect in chronic LBP patients with depression." | 9.20 | Efficacy of tramadol-acetaminophen tablets in low back pain patients with depression. ( Ozaki, T; Tanaka, M; Tetsunaga, T, 2015) |
| "The objective of this study was to determine the analgesic efficacy and safety of intravenous, single-dose paracetamol versus dexketoprofen versus morphine in patients presenting with mechanical low back pain (LBP) to the emergency department (ED)." | 9.19 | Intravenous paracetamol versus dexketoprofen versus morphine in acute mechanical low back pain in the emergency department: a randomised double-blind controlled trial. ( Eken, C; Elicabuk, H; Erdal, M; Serinken, M; Uyanik, E, 2014) |
| "To investigate in acute nonspecific low back pain (LBP) the effectiveness of spinal high-velocity low-amplitude (HVLA) manipulation compared with the nonsteroidal anti-inflammatory drug diclofenac and with placebo." | 9.17 | Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo. ( Muehlbauer, B; Schloemer, P; Timm, J; von Heymann, WJ, 2013) |
| "The goal of this study was to evaluate the efficacy and safety of extended-release tramadol hydrochloride 75-mg/acetaminophen 650-mg fixed-dose combination tablets (TA-ER) for the treatment of chronic low back pain." | 9.17 | A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of the extended-release tramadol hydrochloride/acetaminophen fixed-dose combination tablet for the treatment of chronic low back pain. ( Lee, CS; Lee, JH, 2013) |
| " The objective of this study was to investigate the efficacy and safety of an extended-release, twice-daily fixed combination of 75 mg tramadol/650 mg paracetamol (DDS-06C) in the treatment of moderate-to-severe pain, using acute low back pain as a model." | 9.16 | Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain. ( Bouchard, S; Lasko, B; Levitt, RJ; Rainsford, KD; Robertson, S; Rozova, A, 2012) |
| "To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)." | 9.14 | Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009) |
| "240 patients with acute low back pain who had seen their general practitioner and had been given advice and paracetamol were randomly allocated to one of four groups in our community-based study: diclofenac 50 mg twice daily and placebo manipulative therapy (n=60); spinal manipulative therapy and placebo drug (n=60); diclofenac 50 mg twice daily and spinal manipulative therapy (n=60); or double placebo (n=60)." | 9.12 | Assessment of diclofenac or spinal manipulative therapy, or both, in addition to recommended first-line treatment for acute low back pain: a randomised controlled trial. ( Cooper, CW; Day, RO; Hancock, MJ; Latimer, J; Maher, CG; McAuley, JH; McLachlan, AJ; Spindler, MF, 2007) |
| "5 mg/acetaminophen 325 mg (tramadol/APAP) combination tablets for treatment of chronic low back pain (LBP)." | 9.11 | Analgesic efficacy and safety of tramadol/ acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter, outpatient, randomized, double blind, placebo controlled trial. ( Beaulieu, A; Fortin, L; Kamin, M; Peloso, PM; Rosenthal, N, 2004) |
| "Long-term treatment with tramadol LP once daily is generally safe in patients with osteoarthritis or refractory low back pain." | 9.11 | Long-term tolerability of tramadol LP, a new once-daily formulation, in patients with osteoarthritis or low back pain. ( Coffiner, M; Fontaine, D; Malonne, H; Peretz, A; Sereno, A; Sonet, B; Vanderbist, F, 2005) |
| "5- and 10-mg/acetaminophen 325-mg (Percocet) formulations in patients with low back pain (LBP) suboptimally responsive to nonsteroidal anti-inflammatory drugs, muscle relaxants, tramadol, cyclo-oxygenase-2 inhibitors, and/or prn opioids." | 9.10 | Effectiveness and safety of new oxycodone/acetaminophen formulations with reduced acetaminophen for the treatment of low back pain. ( Domingos, J; Galer, BS; Gammaitoni, AR; Lacouture, P; Schlagheck, T, 2003) |
| "Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain." | 9.10 | Continuous low-level heat wrap therapy provides more efficacy than Ibuprofen and acetaminophen for acute low back pain. ( Abeln, SB; Beth Goodale, M; Erasala, GN; Hengehold, DA; Hinkle, RT; Nadler, SF; Steiner, DJ; Weingand, KW, 2002) |
| "5 mg and ibuprofen 200 mg (HC/IB) with those of combination oxycodone 5 mg and acetaminophen 325 mg (OX/AC) in the treatment of moderate or severe acute low back pain." | 9.10 | Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of moderate or severe acute low back pain. ( Dornseif, BE; Doyle, RT; Morris, E; Palangio, M; Valente, TJ, 2002) |
| "Nimesulide has been evaluated in numerous clinical studies in the management of a variety of acute painful conditions." | 8.31 | An Open-label, Prospective, Multicentric, Cohort Study of Nimesulide/Paracetamol Fixed Drug Combination for Acute Pain Management: Sub-group Analysis. ( Gondane, A; Muruganathan, A; Pawar, D; Tiwaskar, M, 2023) |
| "The objective of this study was to compare the analgesic efficacy and tolerability of tramadol hydrochloride compared with codeine phosphate in combination with paracetamol in patients with moderate-to-severe low back pain caused by osteoarthritis." | 7.78 | [Study of codeine-paracetamol combination treatment compared with tramadol-paracetamol in the control of moderate-to-severe low back pain]. ( Cobianchi, MR; Colini Baldeschi, G, 2012) |
| " IR/ER HB/APAP tablets deliver 25% of the HB dose and 50% of the APAP dose by IR and the remainder by ER over a 12-hour dosing interval." | 6.80 | Tolerability of Biphasic-Release Hydrocodone Bitartrate/Acetaminophen Tablets (MNK-155): A Phase III, Multicenter, Open-Label Study in Patients With Osteoarthritis or Chronic Low Back Pain. ( Barrett, T; Chen, Y; Giuliani, MJ; Hisaw, E; Kostenbader, K; Young, JL; Zheng, Y, 2015) |
| " 210 eligible patients without trauma who presented with low back pain were recruited for the study and randomized into paracetamol (n = 71), dexketoprofen (n = 70), and ibuprofen (n = 69) groups." | 5.51 | Comparative evaluation of the effectiveness of intravenous paracetamol, dexketoprofen and ibuprofen in acute low back pain. ( Dogan, C; Kemanci, A; Oskay, A; Ozen, M; Seyit, M; Turkcuer, I; Uluturk, M; Yilmaz, A, 2022) |
| "Tramadol-acetaminophen was effective at reducing chronic LBP and conferred a prophylactic motivational effect in patients with chronic LBP." | 5.43 | Effect of Tramadol/Acetaminophen on Motivation in Patients with Chronic Low Back Pain. ( Nishida, K; Ozaki, T; Takei, Y; Tanaka, M; Tetsunaga, T, 2016) |
| "To assess the analgesic efficacy and safety of single-dose oral cannabidiol (CBD) as an adjunct to standard care for patients presenting to an emergency department with acute low back pain." | 5.41 | The CANBACK trial: a randomised, controlled clinical trial of oral cannabidiol for people presenting to the emergency department with acute low back pain. ( Bebee, B; Bourke, E; Ching, M; Foster, L; Pollack, K; Taylor, DM; Wong, A, 2021) |
| "Low back pain is very common complaint in all age groups." | 5.38 | To evaluate efficacy and safety of fixed dose combination of aceclofenac + paracetamol + thiocolchicoside (acenac-MR) in the treatment of acute low back pain. ( Lahoti, G, 2012) |
| "Current worldwide clinical practice guidelines recommend acetaminophen as the first option for the treatment of acute low back pain." | 5.27 | Randomized open-label [corrected] non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain. ( Arai, YC; Hayashi, K; Ikemoto, T; Miki, K; Sekiguchi, M; Shi, K; Ushida, T, 2018) |
| "This paper presents the design of the PACE Plus trial: a multi-center, placebo-blinded, superiority randomized controlled trial in primary care that will assess the effectiveness of advice only, paracetamol, diclofenac and placebo for acute low back pain." | 5.24 | Efficacy of paracetamol, diclofenac and advice for acute low back pain in general practice: design of a randomized controlled trial (PACE Plus). ( Koes, BW; Koopmanschap, MA; Luijsterburg, PA; Maher, CG; Rizopoulos, D; Schreijenberg, M; Van Trier, YD; Voogt, L, 2017) |
| "In this randomized controlled trial, we compared the effect of celecoxib and acetaminophen on pain and magnetic resonance imaging (MRI) scores in patients with chronic nonspecific low back pain." | 5.22 | Clinical Efficacy of Celecoxib Compared to Acetaminophen in Chronic Nonspecific Low Back Pain: Results of a Randomized Controlled Trial. ( Bedaiwi, MK; Haroon, N; Inman, RD; O'shea, FD; Omar, A; Salonen, D; Sari, I; Wallis, D, 2016) |
| "Clinical Question Does the addition of cyclobenzaprine or oxycodone with acetaminophen to naproxen result in improved functional outcomes at one week when compared to placebo in patients with acute low back pain? Article Chosen Friedman B, Dym A, Davitt, M, et al." | 5.22 | Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain. ( Gottlieb, M; Njie, A, 2016) |
| "This investigation found that tramadol-acetaminophen is effective for reducing LBP and provided a prophylactic antidepressant effect in chronic LBP patients with depression." | 5.20 | Efficacy of tramadol-acetaminophen tablets in low back pain patients with depression. ( Ozaki, T; Tanaka, M; Tetsunaga, T, 2015) |
| "The objective of this study was to determine the analgesic efficacy and safety of intravenous, single-dose paracetamol versus dexketoprofen versus morphine in patients presenting with mechanical low back pain (LBP) to the emergency department (ED)." | 5.19 | Intravenous paracetamol versus dexketoprofen versus morphine in acute mechanical low back pain in the emergency department: a randomised double-blind controlled trial. ( Eken, C; Elicabuk, H; Erdal, M; Serinken, M; Uyanik, E, 2014) |
| "Paracetamol (acetaminophen) is recommended in most clinical practice guidelines as the first choice of treatment for low back pain, however there is limited evidence to support this recommendation." | 5.17 | PACE--the first placebo controlled trial of paracetamol for acute low back pain: statistical analysis plan. ( Billot, L; Day, RO; Hancock, MJ; Latimer, J; Lin, CW; Maher, CG; McLachlan, AJ; Williams, CM, 2013) |
| "The goal of this study was to evaluate the efficacy and safety of extended-release tramadol hydrochloride 75-mg/acetaminophen 650-mg fixed-dose combination tablets (TA-ER) for the treatment of chronic low back pain." | 5.17 | A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of the extended-release tramadol hydrochloride/acetaminophen fixed-dose combination tablet for the treatment of chronic low back pain. ( Lee, CS; Lee, JH, 2013) |
| "To investigate in acute nonspecific low back pain (LBP) the effectiveness of spinal high-velocity low-amplitude (HVLA) manipulation compared with the nonsteroidal anti-inflammatory drug diclofenac and with placebo." | 5.17 | Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo. ( Muehlbauer, B; Schloemer, P; Timm, J; von Heymann, WJ, 2013) |
| "To compare the efficiency of transcutaneous electrical nerve stimulation (TENS) with those of exercise and acetaminophen for the treatment of pregnancy-related low back pain (LBP) during the third trimester of pregnancy." | 5.16 | Transcutaneous electrical nerve stimulation improves low back pain during pregnancy. ( Gumus, II; Kafali, H; Keskin, EA; Keskin, HL; Onur, O; Turhan, N, 2012) |
| " The objective of this study was to investigate the efficacy and safety of an extended-release, twice-daily fixed combination of 75 mg tramadol/650 mg paracetamol (DDS-06C) in the treatment of moderate-to-severe pain, using acute low back pain as a model." | 5.16 | Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain. ( Bouchard, S; Lasko, B; Levitt, RJ; Rainsford, KD; Robertson, S; Rozova, A, 2012) |
| "To evaluate the adequacy of a low-dose combination of oxycodone and paracetamol (acetaminophen) in patients with multimodal, chronic, non-malignant pain using the Pain Management Index (PMI)." | 5.14 | Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study. ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009) |
| " After Institutional Review Board approval and informed consent, citrated whole blood from 40 patients with chronic unspecific low back pain was investigated before and 30 min after intravenous infusion of the study medication consisting of diclofenac 75 mg (plus orphenadrin 30 mg; Neodolpasse; Fresenius Kabi Austria GmbH, Austria), parecoxib 40 mg (Dynastat; Pharmacia Europe EEIG, UK), paracetamol 1 g (Perfalgan; Bieffe Medital S." | 5.12 | Point-of-care platelet function tests: detection of platelet inhibition induced by nonopioid analgesic drugs. ( Deusch, E; Duris, M; Gebhardt, K; Kozek-Langenecker, S; Scharbert, G; Sow, Z, 2007) |
| "240 patients with acute low back pain who had seen their general practitioner and had been given advice and paracetamol were randomly allocated to one of four groups in our community-based study: diclofenac 50 mg twice daily and placebo manipulative therapy (n=60); spinal manipulative therapy and placebo drug (n=60); diclofenac 50 mg twice daily and spinal manipulative therapy (n=60); or double placebo (n=60)." | 5.12 | Assessment of diclofenac or spinal manipulative therapy, or both, in addition to recommended first-line treatment for acute low back pain: a randomised controlled trial. ( Cooper, CW; Day, RO; Hancock, MJ; Latimer, J; Maher, CG; McAuley, JH; McLachlan, AJ; Spindler, MF, 2007) |
| "Long-term treatment with tramadol LP once daily is generally safe in patients with osteoarthritis or refractory low back pain." | 5.11 | Long-term tolerability of tramadol LP, a new once-daily formulation, in patients with osteoarthritis or low back pain. ( Coffiner, M; Fontaine, D; Malonne, H; Peretz, A; Sereno, A; Sonet, B; Vanderbist, F, 2005) |
| "5 mg/acetaminophen 325 mg (tramadol/APAP) combination tablets for treatment of chronic low back pain (LBP)." | 5.11 | Analgesic efficacy and safety of tramadol/ acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter, outpatient, randomized, double blind, placebo controlled trial. ( Beaulieu, A; Fortin, L; Kamin, M; Peloso, PM; Rosenthal, N, 2004) |
| "5- and 10-mg/acetaminophen 325-mg (Percocet) formulations in patients with low back pain (LBP) suboptimally responsive to nonsteroidal anti-inflammatory drugs, muscle relaxants, tramadol, cyclo-oxygenase-2 inhibitors, and/or prn opioids." | 5.10 | Effectiveness and safety of new oxycodone/acetaminophen formulations with reduced acetaminophen for the treatment of low back pain. ( Domingos, J; Galer, BS; Gammaitoni, AR; Lacouture, P; Schlagheck, T, 2003) |
| "5 mg and ibuprofen 200 mg (HC/IB) with those of combination oxycodone 5 mg and acetaminophen 325 mg (OX/AC) in the treatment of moderate or severe acute low back pain." | 5.10 | Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of moderate or severe acute low back pain. ( Dornseif, BE; Doyle, RT; Morris, E; Palangio, M; Valente, TJ, 2002) |
| "Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain." | 5.10 | Continuous low-level heat wrap therapy provides more efficacy than Ibuprofen and acetaminophen for acute low back pain. ( Abeln, SB; Beth Goodale, M; Erasala, GN; Hengehold, DA; Hinkle, RT; Nadler, SF; Steiner, DJ; Weingand, KW, 2002) |
| " New evidence found that acetaminophen was ineffective for acute low back pain, nonsteroidal anti-inflammatory drugs had smaller benefits for chronic low back pain than previously observed, duloxetine was effective for chronic low back pain, and benzodiazepines were ineffective for radiculopathy." | 4.95 | Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline. ( Chou, R; Dana, T; Deyo, R; Friedly, J; Fu, R; Griffin, J; Grusing, S; Kraegel, P; Skelly, A; Weimer, M, 2017) |
| "Analgesic medication is the most frequently prescribed treatment for low back pain (LBP), of which paracetamol (acetaminophen) is recommended as the first choice medication." | 4.93 | Paracetamol for low back pain. ( Abdel Shaheed, C; Ferreira, ML; Machado, GC; Maher, CG; Pinheiro, MB; Saragiotto, BT, 2016) |
| "The objective of this study was to assess the efficacy of paracetamol (acetaminophen) in the treatment of pain and disability in patients with non-specific low back pain." | 4.84 | A systematic review of paracetamol for non-specific low back pain. ( Davies, RA; Hancock, MJ; Maher, CG, 2008) |
| "Medications with good evidence of short-term effectiveness for low back pain are NSAIDs, acetaminophen, skeletal muscle relaxants (for acute low back pain), and tricyclic antidepressants (for chronic low back pain)." | 4.84 | Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. ( Chou, R; Huffman, LH, 2007) |
| "Nimesulide has been evaluated in numerous clinical studies in the management of a variety of acute painful conditions." | 4.31 | An Open-label, Prospective, Multicentric, Cohort Study of Nimesulide/Paracetamol Fixed Drug Combination for Acute Pain Management: Sub-group Analysis. ( Gondane, A; Muruganathan, A; Pawar, D; Tiwaskar, M, 2023) |
| "Adding cyclobenzaprine or oxycodone/acetaminophen to naproxen for the treatment of acute low back pain does nothing more than increase adverse effects." | 3.83 | PURLs: More isn't better with acute low back pain treatment. ( Frazer, K; Stevermer, JJ, 2016) |
| "The objective of this study was to compare the analgesic efficacy and tolerability of tramadol hydrochloride compared with codeine phosphate in combination with paracetamol in patients with moderate-to-severe low back pain caused by osteoarthritis." | 3.78 | [Study of codeine-paracetamol combination treatment compared with tramadol-paracetamol in the control of moderate-to-severe low back pain]. ( Cobianchi, MR; Colini Baldeschi, G, 2012) |
| "Primary outcomes were low back pain intensity (0-100 scale) at end of treatment and safety (number of participants who reported any adverse event during treatment)." | 3.01 | Comparative effectiveness and safety of analgesic medicines for adults with acute non-specific low back pain: systematic review and network meta-analysis. ( Bagg, MK; Cashin, AG; Day, R; Ferraro, MC; Gustin, SM; Hagstrom, AD; Jones, MD; Leake, HB; Maher, CG; McAuley, JH; McLachlan, AJ; Nikolakopolou, A; O'Connell, NE; Rizzo, RR; Schabrun, S; Sharma, S; Wand, BM; Wewege, MA, 2023) |
| "Acetaminophen and SMRs were inconsistently recommended for acute LBP." | 2.82 | Systematic review of guideline-recommended medications prescribed for treatment of low back pain. ( Bednarz, EM; Cupler, ZA; Daniels, CJ; Hawk, C; Price, MR; Walters, SA, 2022) |
| " IR/ER HB/APAP tablets deliver 25% of the HB dose and 50% of the APAP dose by IR and the remainder by ER over a 12-hour dosing interval." | 2.80 | Tolerability of Biphasic-Release Hydrocodone Bitartrate/Acetaminophen Tablets (MNK-155): A Phase III, Multicenter, Open-Label Study in Patients With Osteoarthritis or Chronic Low Back Pain. ( Barrett, T; Chen, Y; Giuliani, MJ; Hisaw, E; Kostenbader, K; Young, JL; Zheng, Y, 2015) |
| "Our findings suggest that regular or as-needed dosing with paracetamol does not affect recovery time compared with placebo in low-back pain, and question the universal endorsement of paracetamol in this patient group." | 2.79 | Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial. ( Day, RO; Hancock, MJ; Latimer, J; Lin, CW; Maher, CG; McLachlan, AJ; Williams, CM, 2014) |
| "Low back pain is a highly common problem and causes much morbidity and socioeconomic loss in the community." | 2.73 | Caudal epidural injection versus non-steroidal anti-inflammatory drugs in the treatment of low back pain accompanied with radicular pain. ( Cakar, E; Dincer, U; Dursan, H; Kiralp, MZ; Yasar, E, 2007) |
| " Investigations that evaluate more typical dosing regimens are required." | 2.72 | The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews. ( Abdel Shaheed, C; Ahedi, H; Day, RO; Dmitritchenko, A; Ferreira, GE; Kamper, S; Langendyk, V; Latimer, J; Lin, C; Maher, CG; McLachlan, AJ; McLachlan, H; Saragiotto, B; Stanaway, F, 2021) |
| "Patients with at least moderate lower back pain (pain visual analog [PVA] score >/=40 mm on a 100-mm scale) were randomized to receive up to 8 tablets of tramadol/APAP per day or placebo for 91 days." | 2.71 | Tramadol/acetaminophen combination tablets for the treatment of chronic lower back pain: a multicenter, randomized, double-blind, placebo-controlled outpatient study. ( Jordan, D; Kamin, M; Karim, R; Rosenthal, N; Ruoff, GE, 2003) |
| "Acetaminophen has been commonly used as the fi rst-line treatment for OA pain and cLBP, but its long-term use is not recommended based on recent evidence." | 2.61 | Evidence-Based Recommendations on the Pharmacological Management of Osteoarthritis and Chronic Low Back Pain: An Asian Consensus ( Ip, AKK; Murakami, T; Shin, HK; Sun, WZ; Tam, CK; Ushida, T; Wang, JH; Williamson, OD; Yabuki, S, 2019) |
| " The number of patients reporting any adverse event (risk ratio 1." | 2.52 | Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials. ( Day, RO; Ferreira, ML; Ferreira, PH; Lin, CW; Machado, GC; Maher, CG; McLachlan, AJ; Pinheiro, MB, 2015) |
| "Low back pain is a common condition, responsible for significant morbidity and major occupational and economic impact on society." | 2.46 | Low back pain: an approach to diagnosis and management. ( Duffy, RL, 2010) |
| " At the time of intervention, her opioid dosage was between 50-90 MME (Morphine milligram equivalent) (Norco 8 × 7." | 1.56 | Physician-Delivered Pain Neuroscience Education for Opioid Tapering: A Case Report. ( Agarwal, V; Louw, A; Puentedura, EJ, 2020) |
| "Tramadol-acetaminophen was effective at reducing chronic LBP and conferred a prophylactic motivational effect in patients with chronic LBP." | 1.43 | Effect of Tramadol/Acetaminophen on Motivation in Patients with Chronic Low Back Pain. ( Nishida, K; Ozaki, T; Takei, Y; Tanaka, M; Tetsunaga, T, 2016) |
| "The usual treatment of venous ulcers may be associated with statins intake." | 1.42 | [2014 literature findings in internal general medicine]. ( Arnold, C; Barras, D; Bodenmann, P; Chiarini, B; Guinand, S; Pasche, O; Ronga, A; Vu, F; Zürcher, S, 2015) |
| "Low back pain is very common complaint in all age groups." | 1.38 | To evaluate efficacy and safety of fixed dose combination of aceclofenac + paracetamol + thiocolchicoside (acenac-MR) in the treatment of acute low back pain. ( Lahoti, G, 2012) |
| "Recommended pain treatments for osteoarthritis (OA) and chronic low back pain (CLBP) are suboptimal, and limited information is available regarding patterns of pharmacotherapy among patients with these conditions." | 1.38 | Therapy switching, augmentation, and discontinuation in patients with osteoarthritis and chronic low back pain. ( Emery, P; Gore, M; Leslie, DL; Sadosky, AB; Tai, KS, 2012) |
| "Chronic low back pain is a common problem in primary care." | 1.35 | Chronic low back pain: evaluation and management. ( Hulbert, K; Last, AR, 2009) |
| " The risk factors for the development of liver cell necrosis following ingestion of paracetamol in therapeutic dosage are discussed." | 1.30 | [Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage]. ( Krähenbühl, S; Kronenberg, A; Streuli, R; Zimmermann, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (4.92) | 18.2507 |
| 2000's | 28 (22.95) | 29.6817 |
| 2010's | 67 (54.92) | 24.3611 |
| 2020's | 21 (17.21) | 2.80 |
| Authors | Studies |
|---|---|
| Gorfinkel, LR | 1 |
| Hasin, D | 1 |
| Saxon, AJ | 1 |
| Wall, M | 1 |
| Martins, SS | 1 |
| Cerdá, M | 1 |
| Keyes, K | 1 |
| Fink, DS | 1 |
| Keyhani, S | 1 |
| Maynard, CC | 1 |
| Olfson, M | 1 |
| Dogan, C | 1 |
| Yilmaz, A | 1 |
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| Wiener, M | 1 |
| Floman, Y | 1 |
| Vornovskaia, OV | 1 |
| Danilov, AB | 1 |
| Müller, FO | 1 |
| Odendaal, CL | 1 |
| Müller, FR | 1 |
| Raubenheimer, J | 1 |
| Middle, MV | 1 |
| Kummer, M | 1 |
| Orr, KG | 1 |
| Mostert, J | 1 |
| Castle, DJ | 1 |
| Kronenberg, A | 1 |
| Krähenbühl, S | 1 |
| Zimmermann, A | 1 |
| Streuli, R | 1 |
| Antonini Revaz, S | 1 |
| Morabia, A | 1 |
| Goehring, C | 1 |
| Stalder, H | 1 |
| Palangio, M | 1 |
| Morris, E | 1 |
| Doyle, RT | 1 |
| Dornseif, BE | 1 |
| Valente, TJ | 1 |
| Harwood, MI | 1 |
| Chang, SI | 1 |
| Nadler, SF | 1 |
| Steiner, DJ | 1 |
| Erasala, GN | 1 |
| Hengehold, DA | 1 |
| Hinkle, RT | 1 |
| Beth Goodale, M | 1 |
| Abeln, SB | 1 |
| Weingand, KW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Randomized Double-Blind Comparison of Analgesic Efficacy Between Intravenous Forms of Ibuprofen 400 and Ibuprofen 800 mg in Acute Mechanical Low Back Pain in the Emergency Department[NCT06064175] | Phase 4 | 144 participants (Actual) | Interventional | 2022-01-01 | Completed | ||
| A Randomized, Placebo-Controlled, Parallel Group, Double-Blind Clinical Study to Evaluate the Efficacy and Safety of Tramadol HCl/Acetaminophen Extended Release Tablet in Subjects With Chronic Low Back Pain[NCT01112267] | Phase 3 | 248 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| Evaluating Change in Back Pain From Access to a Sit-stand Workstation[NCT02146482] | 57 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| Examination of Palonosetron and Hydroxyzine Pre-treatment as a Possible Method to Reduce the Objective Signs of Experimentally-induced Acute Opioid Withdrawal in Humans: a Double-blind, Randomized, Placebo-controlled Crossover Study[NCT00661674] | 10 participants (Actual) | Interventional | 2008-04-30 | Completed | |||
| An Open Label Safety Study of COV155 in Subjects With Osteoarthritis or Chronic Low Back Pain[NCT01722864] | Phase 3 | 153 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| Short-term Effectiveness of Additional Electrical Stimulation to Exercise Versus Kinesio Taping in Patients With Chronic Low Back Pain: A Randomized Controlled Trial[NCT02812459] | 62 participants (Actual) | Interventional | 2016-06-30 | Completed | |||
| The Effect of Kinesio Taping and Breathing Exercises on Pain Management Applied After Benign Gynecological Abdominal Operation: A Randomized Controlled Study[NCT04412122] | 132 participants (Actual) | Interventional | 2017-06-01 | Completed | |||
| Comparison of Ketoprofen Gel to Placebo in Patients Presented With Mechanical Low Back Pain to the Emergency Department: A Randomized Placebo Controlled Trial[NCT02619695] | Phase 4 | 160 participants (Anticipated) | Interventional | 2015-06-30 | Recruiting | ||
| "Interest of the Return to Primary Care of the Low Back Booklet of Health Insurance in the Recovery of Common Acute Low Back Pain"[NCT03953625] | 33 participants (Actual) | Interventional | 2018-11-29 | Completed | |||
| A Randomized Three-armed Comparative Effectiveness Study of Various Medications for Musculoskeletal Low Back Pain: Defining the Added Benefit of Muscle Relaxants and Opioids.[NCT01587274] | Phase 4 | 323 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| Achieving Peri-Operative Pain Control Without Opioids[NCT04813991] | Phase 3 | 0 participants (Actual) | Interventional | 2022-03-15 | Withdrawn (stopped due to Enrollment was never initiated and the PI is leaving the institution so the study is closing.) | ||
| Aromatherapy for Management of Back Pain in the Emergency Department[NCT03377088] | 60 participants (Anticipated) | Interventional | 2017-12-11 | Recruiting | |||
| Trigger Point Injection for Myofascial Pain Syndrome in the Low Back (T-PIMPS): A Randomized Controlled Trial.[NCT04704297] | Phase 4 | 180 participants (Anticipated) | Interventional | 2020-12-28 | Recruiting | ||
| Electroacupuncture Frequency-related Effects on Chronic Low Back Pain in Older Adults: Triple-blind, 12-month Protocol for a Randomized Controlled Trial.[NCT03802045] | 125 participants (Anticipated) | Interventional | 2019-05-01 | Recruiting | |||
| Can Patient Expectations Influence Pain Reduction After Epidural Injections in Patients With Low Back Pain? An Observational Cohort Study[NCT05402631] | 80 participants (Anticipated) | Observational | 2022-04-20 | Recruiting | |||
| The Effectiveness of Wet Cupping on Persistent Non-specific Low Back Pain: A Randomized, Waiting-list Controlled, Open-label, Parallel-group Pilot Study[NCT00925951] | 37 participants (Anticipated) | Interventional | 2009-06-30 | Completed | |||
| Prospective Randomized Controlled Multicentre Trial for Patients With Chronic Low Back Pain Comparing Disci/Rhus Toxicodendron Comp.®, Placebo and Waiting List Group[NCT00567736] | Phase 3 | 150 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| [NCT00643383] | Phase 3 | 277 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| The Efficacy of Transcutaneous Electrical Nerve Stimulation Versus Local Anaesthetic Cream in Alleviating the Pain of Local Anaesthetic Injections in Adults - A Randomised Controlled Trial[NCT03992820] | 8 participants (Actual) | Interventional | 2019-07-01 | Terminated (stopped due to Stopped early due to COVID19 restrictions) | |||
| The Effects of Spinal Manipulative Therapy on Postactivation Potentiation[NCT02848456] | 20 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| The Influence of the Sacroiliac Joint Manipulation on Changes in the Values of the Center of Pressure in the Process of Maintaining Static Body Balance[NCT04387032] | 59 participants (Actual) | Interventional | 2019-06-15 | Completed | |||
| The Safety and Efficacy of 5% Lidocaine Patch and Flurbiprofen Patch for Relieving Acute Low Back Pain[NCT03171987] | Phase 4 | 120 participants (Anticipated) | Interventional | 2017-06-14 | Recruiting | ||
| A Phase III, Multicenter, Randomized Study to Assess the Efficacy and Safety of 0,5 mg Tizaspray® Administered Intranasally Versus Sirdalud® 2 mg Tablets, in Patients With Acute Low Back Pain[NCT02934061] | Phase 3 | 117 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Tolerability, Safety and Activity of IDN5243, 4 mg Bid Intramuscularly in the Treatment of Low Back Pain. A Prospective, Open Label, Single-center, Uncontrolled Study[NCT02568826] | Phase 2 | 0 participants (Actual) | Interventional | 2016-04-30 | Withdrawn (stopped due to No patients enrolled in the study.) | ||
| Randomized Controlled Trial on the Effectiveness of Immediate Versus Delayed Access to Hospital-based Addiction Services[NCT01934751] | 124 participants (Anticipated) | Interventional | 2013-09-30 | Recruiting | |||
| Comparison of the Effectiveness of 2 Manual Therapies on Functional Outcome in Sub-acute and Chronic Non-specific Low Back Pain at 3 Months : a Randomised Controlled Trial[NCT02034864] | 400 participants (Actual) | Interventional | 2014-02-17 | Completed | |||
| Safety and Efficacy of Nonsteroidal Antiinflammatory Drug and Glucocorticoids in Acute Sciatica[NCT01816334] | Phase 4 | 50 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Global assessment on investigational product was done by investigator on how well the investigational product controlled chronic (lasting a long time) low back pain. Assessment was done by categories 'Very bad (-2)' 'Bad (-1)' 'Not changed (0) 'Good (1)' and 'Very good (2)'. Assessment better than Good was considered as pain improvement success. Percentage of participants with pain improvement success is reported here." (NCT01112267)
Timeframe: Day 29
| Intervention | Percentage of participants (Number) |
|---|---|
| Tramadol HCl/Acetaminophen | 81.25 |
| Placebo | 69.88 |
"Global assessment on investigational product was done by participants on how well the investigational product controlled chronic (lasting a long time) low back pain. Assessment was done by categories 'Very bad (-2)' 'Bad (-1)' 'Not changed (0) 'Good (1)' and 'Very good (2)'. Assessment better than Good was considered as pain improvement success. Percentage of participants with pain improvement success is reported here." (NCT01112267)
Timeframe: Day 29
| Intervention | Percentage of participants (Number) |
|---|---|
| Tramadol HCl/Acetaminophen | 76.25 |
| Placebo | 72.29 |
The percentage of participants with extent of reduction in pain intensity greater than or equal to 30 percent was reported. Pain intensity change rate was calculated by Visual Analog Scale (VAS) score at baseline minus VAS score at Day 29 divided by VAS score at Baseline. VAS is a 10 centimeter (cm) scale. Intensity of pain range: 0 cm=no pain to 10 cm=worst possible pain. (NCT01112267)
Timeframe: Baseline up to Day 29
| Intervention | Percentage of Participants (Number) |
|---|---|
| Tramadol HCl/Acetaminophen | 57.65 |
| Placebo | 41.11 |
The ODI Korean version was used to assess the participant's functionality. The ODI is a low back pain-specific, validated instrument that consists of questions related to limitations in performing specific activities of daily living and 1 question related to pain intensity. The ODI is a self-administered questionnaire consists of 10 sections. Each section consists of 6 statements ranked from 0 to 5 (0=good to 5=worse). Total score is the sum of score obtained in each section and ranges from 0 to 50. A higher score represents greater disability. (NCT01112267)
Timeframe: Baseline and Day 29
| Intervention | Unit on a scale (Mean) | |
|---|---|---|
| Baseline | Change at Day 29 (n=87,83) | |
| Placebo | 38.126 | 7.178 |
| Tramadol HCl/Acetaminophen | 39.626 | 11.216 |
Change in pain intensity experienced by participants over the last 48 hours was measured on Day 29 against Baseline with VAS. VAS is a 10 cm scale. Intensity of pain range: 0 cm=no pain to 10 cm=worst possible pain. (NCT01112267)
Timeframe: Baseline and Day 29
| Intervention | Unit on a scale (Mean) | |
|---|---|---|
| Baseline | Change at Day 29 | |
| Placebo | 6.000 | 1.549 |
| Tramadol HCl/Acetaminophen | 6.334 | 2.299 |
"The quality of life of participants was evaluated by SF-36 Korean version questionnaire. It is composed of 8 domains: physical and social functioning, physical and emotional role limitations, bodily pain, general health, vitality, mental health. Participants answered to the questionnaire of 36 questions; and physical, social, and psychological health status were assessed. It ranges 0 to 100, and higher score indicates better quality of life, But in Reported (Rptd.) Health Transition domain higher score indicates worse quality of life." (NCT01112267)
Timeframe: Baseline and Day 29
| Intervention | Unit on a scale (Mean) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline: Physical functioning | Change at Day 29: Physical functioning (n=83,87) | Baseline: Role physical | Change at Day 29: Role Physical (n=83,87) | Baseline: Bodily pain | Change at Day 29: Bodily pain (n=83,87) | Baseline: General health | Change at Day 29: General health (n=83,87) | Baseline: Vitality | Change at Day 29: Vitality (n=83,87) | Baseline: Social functioning | Change at Day 29: Social functioning (n=83,87) | Baseline: Role emotional | Change at Day 29: Role emotional (n=83,87) | Baseline: Mental Health | Change at Day 29: Mental Health (n=83,87) | Baseline: Rptd. health transition | Change at Day 29: Rptd. health transition(n=83,87) | |
| Placebo | 47.94 | 6.67 | 49.51 | 8.69 | 35.99 | 17.69 | 48.11 | 2.77 | 42.71 | 5.82 | 64.58 | 6.61 | 61.57 | 7.47 | 60.56 | 18.39 | 63.61 | -6.90 |
| Tramadol HCl/Acetaminophen | 46.71 | 9.82 | 44.93 | 16.04 | 34.66 | 19.39 | 43.56 | 7.36 | 38.82 | 11.14 | 64.26 | 11.75 | 61.76 | 8.13 | 61.06 | 20.48 | 65.00 | -18.07 |
Pain relief was measured in 6 stages to assess the participant's pain relief. Extent of pain relief was measured on a scale ranging from 4 to -1, where 4=complete disappearance, 3=fair relief, 2=moderate relief, 1=slight relief, 0=no change and -1=pain worsening. Relief more than 'slight relief (1)' was considered as pain relief success. (NCT01112267)
Timeframe: Day 8, Day 15 and Day 29
| Intervention | Percentage of participants (Number) | ||
|---|---|---|---|
| Day 8: Slight relief (n=82,88) | Day 15: Slight relief (n=85,89) | Day 29, Slight relief (85,89) | |
| Placebo | 53.41 | 65.17 | 77.53 |
| Tramadol HCl/Acetaminophen | 70.73 | 82.35 | 81.18 |
The Roland-Morris Disability Questionnaire is designed to assess self-rated physical disability caused by low back pain. The patient is asked to agree or disagree with 24 different statements related to their back pain. The end score is the sum of the agreed statements. The score ranges from 0 (no disability) to 24 (maximum disability). (NCT02146482)
Timeframe: Baseline (Week 1) and Follow-Up (Week 18)
| Intervention | units on a scale (Median) | |
|---|---|---|
| Baseline | Follow Up | |
| Control | 6 | 4 |
| Sit-stand Computer Workstation | 8.5 | 1.5 |
"The OOWS is a 13-item instrument documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score possible = 13, minimum score possible = 0. T=15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~OOWS scores at T=180 is the primary outcome measure of the study compared with baseline OOWS scores at T=-30 (30 minutes prior to study medication administration). Reported time frames are in relation to time past since administration of study medications.~Mean post-Naloxone OOWS scores (+/- SEM) were determined for pretreatment groups" (NCT00661674)
Timeframe: Change from baseline in OOWS score at 180 minutes (15 minutes post naloxone administration)
| Intervention | units on a scale (OOWS Scale) (Mean) |
|---|---|
| Placebo | 3.5 |
| Palonosetron | 1.0 |
| Palonosetron + Hydroxyzine | 0 |
"The SOWS score is composed of 16 subjective symptoms rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. 15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~The highest score possible (64) would indicate that the individual was experiencing every symptom of opioid withdrawal to the fullest extent possible while the lowest score (0) would indicate that the individual was not experiencing any symptoms of opioid withdrawal.~Mean post-naloxone SOWS scores (+/- SEM) were computed for pretreatment groups: Placebo, palonosetron, and palonosetron with hydroxyzine" (NCT00661674)
Timeframe: Change from baseline in SOWS score at 180 minutes (15 minutes post naloxone administration)
| Intervention | units on a scale (SOWS Scale) (Mean) |
|---|---|
| Placebo | 6.0 |
| Palonosetron | 4.0 |
| Palonosetron + Hydroxyzine | 3.5 |
"The Roland Morris Disability Questionnaire (RMDQ) is a 24 item instrument that evaluates the impact of low back pain on one's daily life. It is most sensitive for patients with mild to moderate disability due to acute, sub-acute or chronic low back pain. Each question can be answered as either a yes or no. The score ranges from 0 to 24 where a higher score reflects greater impairment and, therefore, worsening in the quality of life. The change in RMDQ is obtained by subtracting the RMDQ score at one week after discharge from the baseline score." (NCT01587274)
Timeframe: Baseline and one week after discharge from emergency department
| Intervention | units on a scale (Median) |
|---|---|
| Opioid | 5 |
| Skeletal Muscle Relaxant | 4 |
| Naproxen Alone | 7 |
25 reviews available for acetaminophen and Low Back Pain
| Article | Year |
|---|---|
Systematic review of guideline-recommended medications prescribed for treatment of low back pain.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Opioid; Anti-Bacterial Agents; Anti-Inflammatory | 2022 |
Medications for Treating Low Back Pain in Adults. Evidence for the Use of Paracetamol, Opioids, Nonsteroidal Anti-inflammatories, Muscle Relaxants, Antibiotics, and Antidepressants: An Overview for Musculoskeletal Clinicians.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Opioid; Anti-Bacterial Agents; Anti-Inflammatory Agent | 2022 |
Evidence-based and adverse-effects analyses of cupping therapy in musculoskeletal and sports rehabilitation: A systematic and evidence-based review.
Topics: Acetaminophen; Cupping Therapy; Humans; Low Back Pain; Physical Therapy Modalities; Sports | 2023 |
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Nonopioid pharmacological management of acute low back pain: A level I of evidence systematic review.
Topics: Acetaminophen; Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Humans; Low Back Pain | 2023 |
Comparative effectiveness and safety of analgesic medicines for adults with acute non-specific low back pain: systematic review and network meta-analysis.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics; Female; Humans; Low Back Pain; Male; Network Meta-Anal | 2023 |
Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Bupre | 2023 |
Paracetamol for low back pain: the state of the research field.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Chronic Pain; Humans; Low Back Pain; Randomized | 2020 |
The pharmacological management of chronic lower back pain.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; C | 2021 |
The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Case-Control Studies; Craniotomy; Data Management; Humans; | 2021 |
Which pain medications are effective for sciatica (radicular leg pain)?
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidep | 2017 |
Avoid routinely prescribing medicines for non-specific low back pain.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; An | 2019 |
Evidence-Based Recommendations on the Pharmacological Management of Osteoarthritis and Chronic Low Back Pain: An Asian Consensus
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidep | 2019 |
How to set boundaries with chronic pain patients.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Pain; Decision Support Techniqu | 2014 |
Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Neck Pain; Osteoarthritis, Hip; Oste | 2015 |
A 46-year-old man with acute low-back pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Analgesics, Non-Narcotic; Dose-Response Relationshi | 2016 |
Paracetamol for low back pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Middle Aged; Randomized Controlled T | 2016 |
Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline.
Topics: Acetaminophen; Acute Pain; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; An | 2017 |
Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline.
Topics: Acetaminophen; Acute Pain; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; An | 2017 |
Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline.
Topics: Acetaminophen; Acute Pain; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; An | 2017 |
Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline.
Topics: Acetaminophen; Acute Pain; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; An | 2017 |
A systematic review of paracetamol for non-specific low back pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Data Interpretation, Statistical; Humans; | 2008 |
Pharmacologic treatment for low back pain: one component of pain care.
Topics: Acetaminophen; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-S | 2010 |
Low back pain: an approach to diagnosis and management.
Topics: Acetaminophen; Algorithms; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agent | 2010 |
Pharmacotherapy of low back pain: targeting nociceptive and neuropathic pain components.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antidepressi | 2011 |
Use of medications in the treatment of acute low back pain.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analgesics, O | 2006 |
Use of medications in the treatment of acute low back pain.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analgesics, O | 2006 |
Use of medications in the treatment of acute low back pain.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analgesics, O | 2006 |
Use of medications in the treatment of acute low back pain.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analgesics, O | 2006 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline.
Topics: Acetaminophen; Acute Disease; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2007 |
Clinical inquiries. What is the most effective treatment for acute low back pain?
Topics: Acetaminophen; Adrenal Cortex Hormones; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Bed | 2002 |
47 trials available for acetaminophen and Low Back Pain
| Article | Year |
|---|---|
Comparative evaluation of the effectiveness of intravenous paracetamol, dexketoprofen and ibuprofen in acute low back pain.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double | 2022 |
(C)onsumer focused (E)ducation on p(A)racetamol (S)ide (E)ffects, i(N)adequate (O)utcomes and (W)eaning (CEASE NOW) for individuals with low back pain: results of a feasibility study.
Topics: Acetaminophen; Adult; Feasibility Studies; Humans; Low Back Pain; Outcome Assessment, Health Care; P | 2022 |
(C)onsumer focused (E)ducation on p(A)racetamol (S)ide (E)ffects, i(N)adequate (O)utcomes and (W)eaning (CEASE NOW) for individuals with low back pain: results of a feasibility study.
Topics: Acetaminophen; Adult; Feasibility Studies; Humans; Low Back Pain; Outcome Assessment, Health Care; P | 2022 |
(C)onsumer focused (E)ducation on p(A)racetamol (S)ide (E)ffects, i(N)adequate (O)utcomes and (W)eaning (CEASE NOW) for individuals with low back pain: results of a feasibility study.
Topics: Acetaminophen; Adult; Feasibility Studies; Humans; Low Back Pain; Outcome Assessment, Health Care; P | 2022 |
(C)onsumer focused (E)ducation on p(A)racetamol (S)ide (E)ffects, i(N)adequate (O)utcomes and (W)eaning (CEASE NOW) for individuals with low back pain: results of a feasibility study.
Topics: Acetaminophen; Adult; Feasibility Studies; Humans; Low Back Pain; Outcome Assessment, Health Care; P | 2022 |
(C)onsumer focused (E)ducation on p(A)racetamol (S)ide (E)ffects, i(N)adequate (O)utcomes and (W)eaning (CEASE NOW) for individuals with low back pain: results of a feasibility study.
Topics: Acetaminophen; Adult; Feasibility Studies; Humans; Low Back Pain; Outcome Assessment, Health Care; P | 2022 |
(C)onsumer focused (E)ducation on p(A)racetamol (S)ide (E)ffects, i(N)adequate (O)utcomes and (W)eaning (CEASE NOW) for individuals with low back pain: results of a feasibility study.
Topics: Acetaminophen; Adult; Feasibility Studies; Humans; Low Back Pain; Outcome Assessment, Health Care; P | 2022 |
(C)onsumer focused (E)ducation on p(A)racetamol (S)ide (E)ffects, i(N)adequate (O)utcomes and (W)eaning (CEASE NOW) for individuals with low back pain: results of a feasibility study.
Topics: Acetaminophen; Adult; Feasibility Studies; Humans; Low Back Pain; Outcome Assessment, Health Care; P | 2022 |
(C)onsumer focused (E)ducation on p(A)racetamol (S)ide (E)ffects, i(N)adequate (O)utcomes and (W)eaning (CEASE NOW) for individuals with low back pain: results of a feasibility study.
Topics: Acetaminophen; Adult; Feasibility Studies; Humans; Low Back Pain; Outcome Assessment, Health Care; P | 2022 |
(C)onsumer focused (E)ducation on p(A)racetamol (S)ide (E)ffects, i(N)adequate (O)utcomes and (W)eaning (CEASE NOW) for individuals with low back pain: results of a feasibility study.
Topics: Acetaminophen; Adult; Feasibility Studies; Humans; Low Back Pain; Outcome Assessment, Health Care; P | 2022 |
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Paracetamol is ineffective for acute low back pain even for patients who comply with treatment: complier average causal effect analysis of a randomized controlled trial.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Humans; Low Back Pa | 2019 |
Ibuprofen Plus Acetaminophen Versus Ibuprofen Alone for Acute Low Back Pain: An Emergency Department-based Randomized Study.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Inferential reproduction analysis demonstrated that "paracetamol for acute low back pain" trial conclusions were reproducible.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Confidence Intervals; Early Termination | 2020 |
The CANBACK trial: a randomised, controlled clinical trial of oral cannabidiol for people presenting to the emergency department with acute low back pain.
Topics: Acetaminophen; Acute Pain; Administration, Oral; Adult; Australia; Cannabidiol; Double-Blind Method; | 2021 |
Patient Nonadherence to Guideline-Recommended Care in Acute Low Back Pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Insurance Coverage; Insurance, Health; Low | 2017 |
Randomized open-label [corrected] non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2018 |
Intravenous paracetamol versus dexketoprofen versus morphine in acute mechanical low back pain in the emergency department: a randomised double-blind controlled trial.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Analysis of Variance; Anti-Inflammatory Agents, Non | 2014 |
PACE--the first placebo controlled trial of paracetamol for acute low back pain: statistical analysis plan.
Topics: Acetaminophen; Acute Pain; Analgesics; Data Interpretation, Statistical; Disability Evaluation; Doub | 2013 |
A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of the extended-release tramadol hydrochloride/acetaminophen fixed-dose combination tablet for the treatment of chronic low back pain.
Topics: Acetaminophen; Adult; Aged; Analgesics; Chronic Pain; Delayed-Action Preparations; Double-Blind Meth | 2013 |
Do analgesics improve functioning in patients with chronic low back pain? An explorative triple-blinded RCT.
Topics: Acetaminophen; Adult; Analgesics; Chronic Pain; Disability Evaluation; Double-Blind Method; Drug Adm | 2014 |
Predicting rapid recovery from acute low back pain based on the intensity, duration and history of pain: a validation study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Female; Humans; Low Back Pain; Male; Middle Aged; Pa | 2014 |
Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial.
Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Drug Administration | 2014 |
Efficacy of tramadol-acetaminophen tablets in low back pain patients with depression.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-In | 2015 |
Tolerability of Biphasic-Release Hydrocodone Bitartrate/Acetaminophen Tablets (MNK-155): A Phase III, Multicenter, Open-Label Study in Patients With Osteoarthritis or Chronic Low Back Pain.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Pain; Delayed-Acti | 2015 |
The effect of Kinesio taping application for acute non-specific low back pain: a randomized controlled clinical trial.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Athletic Tape; Combined Modality T | 2016 |
The effect of Kinesio taping application for acute non-specific low back pain: a randomized controlled clinical trial.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Athletic Tape; Combined Modality T | 2016 |
The effect of Kinesio taping application for acute non-specific low back pain: a randomized controlled clinical trial.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Athletic Tape; Combined Modality T | 2016 |
The effect of Kinesio taping application for acute non-specific low back pain: a randomized controlled clinical trial.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Athletic Tape; Combined Modality T | 2016 |
Clinical Efficacy of Celecoxib Compared to Acetaminophen in Chronic Nonspecific Low Back Pain: Results of a Randomized Controlled Trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Celecoxib; Female; Humans; Low Back Pain; Magnetic R | 2016 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Evaluation of Efficacy of Bone Scan With SPECT/CT in the Management of Low Back Pain: A Study Supported by Differential Diagnostic Local Anesthetic Blocks.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Bone and Bones; Disease Man | 2015 |
Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Amitriptyline; Dose-Response Relationship | 2016 |
The economic burden of guideline-recommended first line care for acute low back pain.
Topics: Acetaminophen; Acute Pain; Adult; Australia; Cost of Illness; Costs and Cost Analysis; Female; Healt | 2018 |
Efficacy of paracetamol, diclofenac and advice for acute low back pain in general practice: design of a randomized controlled trial (PACE Plus).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Direct | 2017 |
O-demethylation of codeine to morphine inhibited by low-dose levomepromazine.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Code | 2009 |
Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain : a prospective observational study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2009 |
Can predictors of response to NSAIDs be identified in patients with acute low back pain?
Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida | 2009 |
PACE--the first placebo controlled trial of paracetamol for acute low back pain: design of a randomised controlled trial.
Topics: Acetaminophen; Activities of Daily Living; Acute Disease; Analgesia; Analgesics, Non-Narcotic; Clini | 2010 |
Evaluation of wet-cupping therapy for persistent non-specific low back pain: a randomised, waiting-list controlled, open-label, parallel-group pilot trial.
Topics: Acetaminophen; Acupuncture Points; Acupuncture Therapy; Adult; Analgesics, Non-Narcotic; Disability | 2011 |
Balneotherapy for chronic low back pain: a randomized, controlled study.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Balneology; Chi-Square Distribu | 2012 |
Efficacy of injections with Disci/Rhus toxicodendron compositum for chronic low back pain--a randomized placebo-controlled trial.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chron | 2011 |
Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Dizziness; Double-Blind Method; Drug Admi | 2012 |
Transcutaneous electrical nerve stimulation improves low back pain during pregnancy.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Exercise Therapy; Female; Humans; Low Back Pain; Pai | 2012 |
Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo.
Topics: Absenteeism; Acetaminophen; Acute Pain; Adolescent; Adult; Ambulatory Care; Anti-Inflammatory Agents | 2013 |
Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo.
Topics: Absenteeism; Acetaminophen; Acute Pain; Adolescent; Adult; Ambulatory Care; Anti-Inflammatory Agents | 2013 |
Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo.
Topics: Absenteeism; Acetaminophen; Acute Pain; Adolescent; Adult; Ambulatory Care; Anti-Inflammatory Agents | 2013 |
Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo.
Topics: Absenteeism; Acetaminophen; Acute Pain; Adolescent; Adult; Ambulatory Care; Anti-Inflammatory Agents | 2013 |
Tramadol/acetaminophen combination tablets for the treatment of chronic lower back pain: a multicenter, randomized, double-blind, placebo-controlled outpatient study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Dose-Resp | 2003 |
Effectiveness and safety of new oxycodone/acetaminophen formulations with reduced acetaminophen for the treatment of low back pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Humans; Low Back Pain; M | 2003 |
Acupuncture for low back pain in pregnancy--a prospective, quasi-randomised, controlled study.
Topics: Acetaminophen; Acupuncture Therapy; Adult; Analgesics, Non-Narcotic; Female; Humans; Low Back Pain; | 2004 |
Analgesic efficacy and safety of tramadol/ acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter, outpatient, randomized, double blind, placebo controlled trial.
Topics: Acetaminophen; Adult; Aged; Ambulatory Care; Analgesics, Non-Narcotic; Chronic Disease; Dose-Respons | 2004 |
Long-term tolerability of tramadol LP, a new once-daily formulation, in patients with osteoarthritis or low back pain.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Drug Administration Sche | 2005 |
Efficacy and tolerability of paracetamol/tramadol (325 mg/37.5 mg) combination treatment compared with tramadol (50 mg) monotherapy in patients with subacute low back pain: a multicenter, randomized, double-blind, parallel-group, 10-day treatment study.
Topics: Acetaminophen; Double-Blind Method; Drug Therapy, Combination; Humans; Low Back Pain; Tramadol; Trea | 2006 |
Caudal epidural injection versus non-steroidal anti-inflammatory drugs in the treatment of low back pain accompanied with radicular pain.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid | 2007 |
Point-of-care platelet function tests: detection of platelet inhibition induced by nonopioid analgesic drugs.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Blood Platelets; Cyclooxygenase Inhibitors; Di | 2007 |
Assessment of diclofenac or spinal manipulative therapy, or both, in addition to recommended first-line treatment for acute low back pain: a randomised controlled trial.
Topics: Acetaminophen; Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Hu | 2007 |
Overexertional lumbar and thoracic back pain among recruits: a prospective study of risk factors and treatment regimens.
Topics: Acetaminophen; Adolescent; Anthropometry; Back Pain; Body Mass Index; Cumulative Trauma Disorders; H | 1993 |
Comparison of the efficacy and tolerability of a paracetamol/codeine fixed-dose combination with tramadol in patients with refractory chronic back pain.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Cross-Over Studie | 1998 |
Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of moderate or severe acute low back pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2002 |
Continuous low-level heat wrap therapy provides more efficacy than Ibuprofen and acetaminophen for acute low back pain.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Female; Follow-Up Studies | 2002 |
51 other studies available for acetaminophen and Low Back Pain
| Article | Year |
|---|---|
Trends in Prescriptions for Non-opioid Pain Medications Among U.S. Adults With Moderate or Severe Pain, 2014-2018.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Anti-Inflammatory Agents; Antidepressive Agents; Drug Pres | 2022 |
OTC Analgesics vs Opioids for Pain Management.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2022 |
Paracetamol Use in Patients With Osteoarthritis and Lower Back Pain: Infodemiology Study and Observational Analysis of Electronic Medical Record Data.
Topics: Acetaminophen; Adult; Electronic Health Records; Female; Humans; Infodemiology; Low Back Pain; Male; | 2022 |
An Open-label, Prospective, Multicentric, Cohort Study of Nimesulide/Paracetamol Fixed Drug Combination for Acute Pain Management: Sub-group Analysis.
Topics: Acetaminophen; Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Drug Combination | 2023 |
Barriers and facilitators to reducing paracetamol use in low back pain: A qualitative study.
Topics: Acetaminophen; Health Personnel; Humans; Low Back Pain; Qualitative Research; Self Report | 2023 |
Physician-Delivered Pain Neuroscience Education for Opioid Tapering: A Case Report.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Chronic Pain; Female; Fentanyl; Humans; Hydrocodone; Low Ba | 2020 |
Comment on Miki et al.: Randomized open-label non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Phenylpropionates | 2019 |
Clinical inquiry. How can pregnant women safely relieve low-back pain?
Topics: Acetaminophen; Evidence-Based Medicine; Female; Humans; Low Back Pain; Physical Therapy Modalities; | 2013 |
Trial registration: must take place before or at the onset of enrolment.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female | 2014 |
Poor sleep quality is strongly associated with subsequent pain intensity in patients with acute low back pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Female; Follow-Up Studies; Humans; Longitudinal Stud | 2014 |
Do patients with acute low-back pain need paracetamol?
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Female; Humans; Low Back Pain; Male | 2014 |
Pain: Paracetamol is not superior to placebo for acute low back pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Placebos; Randomized Controlled Tria | 2014 |
[Signalled off-side play against paracetamol in treating low back pain].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Australia; Female; Humans; Low Back Pain; Male; Middle Aged | 2014 |
Ergonomics: The only way.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Dentists; Ergonomics; Humans; Low Back Pain; Occupational D | 2014 |
[Not Available].
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Female; Humans; Low Back Pain; Male | 2014 |
Up to 4000 mg of paracetamol a day is ineffective for acute low back pain.
Topics: Acetaminophen; Acute Pain; Analgesics, Non-Narcotic; Female; Humans; Low Back Pain; Male | 2015 |
[2014 literature findings in internal general medicine].
Topics: Acetaminophen; Adolescent; Aged; Analgesics, Non-Narcotic; Bronchitis; Bullying; Colorectal Neoplasm | 2015 |
The effects of educational interventions on pharmacists' knowledge, attitudes and beliefs towards low back pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Education; Education, Pharmacy, Continuing; Female; | 2015 |
Danger of generalising findings on paracetamol for low back pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Neck Pain; Osteoarthritis, Hip; Oste | 2015 |
Paracetamol should remain the first line option for persistent pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Neck Pain; Osteoarthritis, Hip; Oste | 2015 |
Authors' reply to Adam and to Veal and Thompson.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Neck Pain; Osteoarthritis, Hip; Oste | 2015 |
Study findings on acetaminophen at odds with clinical guidelines.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Osteoarthritis; Practice Guidelines | 2015 |
[My Back is Still Hurting!].
Topics: Acetaminophen; Adult; Biopsy; Bone and Bones; Diagnosis, Differential; Diagnostic Imaging; Eunuchism | 2015 |
[Paracetamol is ineffective for back pain and only minimally effective for osteoarthritis].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Neck Pain; Osteoarthritis, Hip; Oste | 2015 |
ACP Journal Club. Review: Acetaminophen reduces pain in hip or knee osteoarthritis by a small amount, but not low back pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Neck Pain; Osteoarthritis, Hip; Oste | 2015 |
Paracetamol is ineffective for spinal pain and knee and hip osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Low Back Pain; Neck Pain; Osteoarthritis, Hip; Oste | 2015 |
The ineffectiveness of paracetamol for spinal pain provides opportunities to better manage low back pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Back Pain; Exercise Therapy; Humans; Low Back Pain; Patient | 2016 |
ACP Journal Club. In acute low back pain, adding oxycodone/acetaminophen or cyclobenzaprine to naproxen did not improve pain or function.
Topics: Acetaminophen; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; H | 2016 |
Effect of Tramadol/Acetaminophen on Motivation in Patients with Chronic Low Back Pain.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Apathy; | 2016 |
PURLs: More isn't better with acute low back pain treatment.
Topics: Acetaminophen; Amitriptyline; Drug Combinations; Female; Humans; Low Back Pain; Male; Muscle Relaxan | 2016 |
Second-Order Peer Reviews of Clinically Relevant Articles for the Physiatrist: Naproxen with Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo to Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Amitriptyline; Humans; Low Back Pain; Naproxen; Oxycodone; Peer Review; Physiatrists | 2017 |
Chronic low back pain: evaluation and management.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Exerci | 2009 |
Guideline update: what's the best approach to acute low back pain?
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cry | 2009 |
[44 year old gardener with lower back pain, myalgia and fever].
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Analgesics, Non-Narcotic; Child; Clinical Trials as T | 2010 |
[Drug therapy of acute low back pain].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Hum | 2010 |
Therapy switching, augmentation, and discontinuation in patients with osteoarthritis and chronic low back pain.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-In | 2012 |
Is spinal manipulation an effective treatment for low back pain? No: evidence shows no clinically significant benefit over watchful waiting.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Low Back P | 2012 |
[Study of codeine-paracetamol combination treatment compared with tramadol-paracetamol in the control of moderate-to-severe low back pain].
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Therapy, Combinatio | 2012 |
To evaluate efficacy and safety of fixed dose combination of aceclofenac + paracetamol + thiocolchicoside (acenac-MR) in the treatment of acute low back pain.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diclofe | 2012 |
[Acute pancreatitis induced by codeine-acetaminophen association: report of two cases].
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Em | 2003 |
Prognosis and quality of life in patients with acute low back pain: insights from a comprehensive inception cohort study.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Cohort Studies; Disability Evaluation | 2004 |
Chronic back pain: searching for causes and cures.
Topics: Acetaminophen; Chronic Disease; Drug Therapy, Combination; Humans; Low Back Pain; Pain Measurement; | 2004 |
Photodynamic therapy.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Female; Humans; Low Back Pain; Male; Pain Measurement | 2005 |
Efficacy and safety of acupuncture for the treatment of non-specific acute low back pain: a randomised controlled multicentre trial protocol [ISRCTN65814467].
Topics: Acetaminophen; Acupuncture; Acute Disease; Adult; Amitriptyline; Analgesics; Bayes Theorem; Clinical | 2006 |
Acute renal failure in a patient with familial Mediterranean fever.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Amyloidosis; Anti-Inflammatory Agents, Non-Steroidal | 2007 |
Evidence-based management of acute low back pain.
Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Evidence-Based Me | 2007 |
Overviews and systematic reviews on low back pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Low Back P | 2008 |
[Caffetin in the treatment of neck pain and lumbago-sciatica].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Caffeine; Codeine; Drug Combinat | 1997 |
Mania associated with codeine and paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Bipolar Disorder; Codeine; Drug Combina | 1998 |
[Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Drug | 1998 |
[Evaluation of drug prescription in the primary care clinic in Geneva in 1997].
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Community He | 1999 |