acetaminophen has been researched along with Liver Steatosis in 34 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The degree of liver inflammation and hepatocellular necrosis were significantly higher in HFGD fed animals after acetaminophen administration." | 7.78 | Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. ( Cervinková, Z; Haňáčková, L; Kučera, O; Lotková, H; Podhola, M; Roušar, T; Staňková, P, 2012) |
| ": The aim of the study was to evaluate UDP-glucuronyltransferase activity and the pharmacokinetics of a single oral dose of acetaminophen (APAP) in children with nonalcoholic fatty liver disease (NAFLD)." | 7.77 | Acetaminophen pharmacokinetics in children with nonalcoholic fatty liver disease. ( Barshop, NJ; Capparelli, EV; Lavine, JE; Schwimmer, JB; Sirlin, CB, 2011) |
| " Despite abundant experimental data showing that fatty liver is more susceptible to liver injury, drug-induced liver disease seems no more frequent in NAFLD patients, except, possibly, a higher incidence but not severity of acetaminophen hepatotoxicity." | 4.90 | The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease. ( Pais, R; Ratziu, V; Rusu, E, 2014) |
| "The degree of liver inflammation and hepatocellular necrosis were significantly higher in HFGD fed animals after acetaminophen administration." | 3.78 | Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. ( Cervinková, Z; Haňáčková, L; Kučera, O; Lotková, H; Podhola, M; Roušar, T; Staňková, P, 2012) |
| "Clinical investigations suggest that hepatotoxicity after acetaminophen (APAP) overdose could be more severe in the context of obesity and nonalcoholic fatty liver disease." | 3.78 | Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. ( Aubert, J; Begriche, K; Delannoy, M; Fromenty, B; Jaeschke, H; Lepage, S; Lucas-Clerc, C; McGill, MR; Morel, I; Pajaud, J; Ribault, C; Robin, MA; Turlin, B, 2012) |
| ": The aim of the study was to evaluate UDP-glucuronyltransferase activity and the pharmacokinetics of a single oral dose of acetaminophen (APAP) in children with nonalcoholic fatty liver disease (NAFLD)." | 3.77 | Acetaminophen pharmacokinetics in children with nonalcoholic fatty liver disease. ( Barshop, NJ; Capparelli, EV; Lavine, JE; Schwimmer, JB; Sirlin, CB, 2011) |
| "Acute liver failure is a rare but life-threatening medical emergency in pregnancy whose true incidence remains unknown." | 2.53 | Liver Failure in Pregnancy. ( Bacak, SJ; Thornburg, LL, 2016) |
| "Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, representing a spectrum of liver pathologies that include simple hepatic steatosis and the more advanced nonalcoholic steatohepatitis (NASH)." | 1.42 | Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis. ( A-Kader, HH; Bataille, AM; Campion, SN; Canet, MJ; Cherrington, NJ; Erickson, RP; Ferreira, DW; Hardwick, RN; Manautou, JE; Merrell, MD; Xanthakos, SA, 2015) |
| "Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of liver damage ranging from steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis." | 1.39 | Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease. ( Cherrington, NJ; Ferreira, DW; Hardwick, RN; Lake, AD; Lu, Z; Manautou, JE; More, VR; Slitt, AL, 2013) |
| "All clofibrate pretreated steatohepatitic mice receiving APAP exhibited lower liver injury, which did not progress and the mice survived." | 1.35 | Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate. ( Bhave, VS; Donthamsetty, S; Latendresse, JR; Mehendale, HM; Mitra, MS, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (23.53) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 18 (52.94) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Morales-Romero, J | 1 |
| Ortíz-León, MC | 1 |
| Hernández-Gutiérrez, H | 1 |
| Bahena-Cerón, RA | 1 |
| Miranda-Reza, A | 1 |
| Marín-Carmona, JA | 1 |
| Rodríguez-Romero, E | 1 |
| Mora, SI | 1 |
| García-Román, J | 1 |
| Peréz-Carreón, JI | 1 |
| Rivadeneyra-Domínguez, E | 1 |
| Riande-Juárez, G | 1 |
| García-Román, R | 1 |
| Lee-Montiel, FT | 1 |
| George, SM | 1 |
| Gough, AH | 1 |
| Sharma, AD | 1 |
| Wu, J | 1 |
| DeBiasio, R | 1 |
| Vernetti, LA | 1 |
| Taylor, DL | 1 |
| Kushner, T | 1 |
| Tholey, D | 1 |
| Dodge, J | 1 |
| Saberi, B | 1 |
| Schiano, T | 1 |
| Terrault, N | 1 |
| Mun, SJ | 1 |
| Ryu, JS | 1 |
| Lee, MO | 1 |
| Son, YS | 1 |
| Oh, SJ | 1 |
| Cho, HS | 1 |
| Son, MY | 1 |
| Kim, DS | 1 |
| Kim, SJ | 1 |
| Yoo, HJ | 1 |
| Lee, HJ | 2 |
| Kim, J | 1 |
| Jung, CR | 1 |
| Chung, KS | 1 |
| Son, MJ | 1 |
| Chen, Y | 1 |
| Dong, H | 1 |
| Thompson, DC | 1 |
| Shertzer, HG | 1 |
| Nebert, DW | 1 |
| Vasiliou, V | 1 |
| Pais, R | 1 |
| Rusu, E | 1 |
| Ratziu, V | 1 |
| Canet, MJ | 1 |
| Merrell, MD | 1 |
| Hardwick, RN | 2 |
| Bataille, AM | 1 |
| Campion, SN | 1 |
| Ferreira, DW | 2 |
| Xanthakos, SA | 1 |
| Manautou, JE | 3 |
| A-Kader, HH | 1 |
| Erickson, RP | 1 |
| Cherrington, NJ | 3 |
| Previs, SF | 1 |
| Kelley, DE | 1 |
| Bacak, SJ | 1 |
| Thornburg, LL | 1 |
| Adukauskiene, D | 1 |
| Dockiene, I | 1 |
| Naginiene, R | 1 |
| Kevelaitis, E | 1 |
| Pundzius, J | 1 |
| Kupcinskas, L | 1 |
| Barshop, NJ | 1 |
| Capparelli, EV | 1 |
| Sirlin, CB | 1 |
| Schwimmer, JB | 1 |
| Lavine, JE | 1 |
| Kučera, O | 2 |
| Roušar, T | 2 |
| Staňková, P | 1 |
| Haňáčková, L | 1 |
| Lotková, H | 2 |
| Podhola, M | 1 |
| Cervinková, Z | 2 |
| Xu, J | 1 |
| Kulkarni, SR | 1 |
| Li, L | 1 |
| Slitt, AL | 3 |
| Lee, CH | 1 |
| Kuo, CY | 1 |
| Wang, CJ | 1 |
| Wang, CP | 1 |
| Lee, YR | 1 |
| Hung, CN | 1 |
| Aubert, J | 2 |
| Begriche, K | 1 |
| Delannoy, M | 1 |
| Morel, I | 2 |
| Pajaud, J | 1 |
| Ribault, C | 1 |
| Lepage, S | 2 |
| McGill, MR | 1 |
| Lucas-Clerc, C | 1 |
| Turlin, B | 1 |
| Robin, MA | 1 |
| Jaeschke, H | 1 |
| Fromenty, B | 2 |
| Seki, E | 1 |
| Brenner, DA | 1 |
| Karin, M | 1 |
| Kubes, P | 1 |
| Mehal, WZ | 1 |
| Al-Dury, S | 1 |
| Rychtrmoc, D | 1 |
| More, VR | 1 |
| Lake, AD | 1 |
| Lu, Z | 1 |
| Gicquel, T | 1 |
| Ito, Y | 1 |
| Abril, ER | 1 |
| Bethea, NW | 1 |
| McCuskey, MK | 1 |
| McCuskey, RS | 1 |
| Yohe, HC | 1 |
| O'Hara, KA | 1 |
| Hunt, JA | 1 |
| Kitzmiller, TJ | 1 |
| Wood, SG | 1 |
| Bement, JL | 1 |
| Bement, WJ | 1 |
| Szakacs, JG | 1 |
| Wrighton, SA | 1 |
| Jacobs, JM | 1 |
| Kostrubsky, V | 1 |
| Sinclair, PR | 1 |
| Sinclair, JF | 1 |
| Bilzer, M | 1 |
| Roggel, F | 1 |
| Gerbes, AL | 1 |
| Lickteig, AJ | 1 |
| Fisher, CD | 1 |
| Augustine, LM | 1 |
| Aleksunes, LM | 1 |
| Besselsen, DG | 1 |
| Donthamsetty, S | 1 |
| Bhave, VS | 1 |
| Mitra, MS | 1 |
| Latendresse, JR | 1 |
| Mehendale, HM | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
| Poulsen, HE | 1 |
| Petersen, P | 1 |
| Vilstrup, H | 1 |
| Shavila, J | 1 |
| Ioannides, C | 1 |
| King, LJ | 1 |
| Parke, DV | 1 |
| Olsson, R | 1 |
| Gazzard, BG | 1 |
| Portmann, B | 1 |
| Murray-Lyon, IM | 1 |
| Williams, R | 1 |
| Knoblauch, M | 1 |
| Lämmli, J | 1 |
| Funk, C | 1 |
| Hathcock, JN | 1 |
| Chalstrey, LJ | 2 |
| Parbhoo, SP | 2 |
| Adjukiewicz, AB | 1 |
| James, IM | 1 |
| Hillenbrand, P | 1 |
| Kennedy, J | 1 |
7 reviews available for acetaminophen and Liver Steatosis
| Article | Year |
|---|---|
Glutathione defense mechanism in liver injury: insights from animal models.
Topics: Acetaminophen; Animals; Disease Models, Animal; Fatty Liver; Gene Deletion; Glutamate-Cysteine Ligas | 2013 |
The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease.
Topics: Acetaminophen; Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; He | 2014 |
Liver Failure in Pregnancy.
Topics: Abortion, Therapeutic; Acetaminophen; Critical Care; Drug Overdose; Fatty Liver; Female; HELLP Syndr | 2016 |
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Death; | 2012 |
Sterile inflammation in the liver.
Topics: Acetaminophen; Adenosine Triphosphate; Caspase 1; Chemical and Drug Induced Liver Injury; Chemotaxis | 2012 |
Role of Kupffer cells in host defense and liver disease.
Topics: Acetaminophen; Animals; Cell Communication; Fatty Liver; Hemoglobins; Humans; Immune Tolerance; Immu | 2006 |
Nutrient and non-nutrient effects on drug metabolism.
Topics: Acetaminophen; Aged; Antioxidants; Biological Transport; Biotransformation; Carbohydrate Metabolism; | 1985 |
27 other studies available for acetaminophen and Liver Steatosis
| Article | Year |
|---|---|
[Risk factors for metabolic dysfunction-associated fatty liver disease in the Hispanic-Mexican population.]
Topics: Acetaminophen; Fatty Liver; Hispanic or Latino; Humans; Mexico; Obesity; Risk Factors; Spain | 2023 |
Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems.
Topics: Acetaminophen; Cell Line; Fatty Liver; Glucose; Glycolysis; Hepatocytes; Humans; Interleukin-6; Lab- | 2017 |
Outcomes of liver transplantation for acute fatty liver disease of pregnancy.
Topics: Acetaminophen; Adolescent; Adult; Case-Control Studies; Fatty Liver; Female; Follow-Up Studies; Graf | 2019 |
Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids.
Topics: Acetaminophen; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Drug Evaluation, Prec | 2019 |
Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Bile Canaliculi; Biotransformation; Child; Coho | 2015 |
Tracer-based assessments of hepatic anaplerotic and TCA cycle flux: practicality, stoichiometry, and hidden assumptions.
Topics: Acetaminophen; Acetates; Blood Glucose; Carbon Isotopes; Citric Acid Cycle; Fatty Liver; Glutamic Ac | 2015 |
Acute liver failure in Lithuania.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Bilirubin; Chemical and Drug Induced Liver Injury; Co | 2008 |
Acetaminophen pharmacokinetics in children with nonalcoholic fatty liver disease.
Topics: Acetaminophen; Adolescent; Case-Control Studies; Child; Fatty Liver; Glucuronosyltransferase; Humans | 2011 |
Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen.
Topics: Acetaminophen; Animals; Biomarkers; Caspase 3; Chemical and Drug Induced Liver Injury; Cholesterol; | 2012 |
UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Enzyme Induction; Fasting; Fatty | 2012 |
A polyphenol extract of Hibiscus sabdariffa L. ameliorates acetaminophen-induced hepatic steatosis by attenuating the mitochondrial dysfunction in vivo and in vitro.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis Regulatory Proteins; Catalase; Cell Death; Fatty Liv | 2012 |
Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.
Topics: 3-Hydroxybutyric Acid; Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P- | 2012 |
Steatotic rat hepatocytes in primary culture are more susceptible to the acute toxic effect of acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Fatty Liver; Glutathione; | 2012 |
Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease.
Topics: Acetaminophen; Biotransformation; Disease Progression; Fatty Liver; Gene Expression Regulation, Enzy | 2013 |
Quantitative analysis of acetaminophen and its primary metabolites in small plasma volumes by liquid chromatography-tandem mass spectrometry.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Calibration; Chromatography, High Pressure Liquid; | 2013 |
Dietary steatotic liver attenuates acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2006 |
Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Synergism; Ethanol; Fatty Liver; Female; Live | 2006 |
Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; ATP-Binding Cassette Transporters; Bile; Diet; Dis | 2007 |
Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Animals; Clofibrate; Cytochrome P-450 C | 2008 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Quantitative liver function and morphology after paracetamol administration to rats.
Topics: Acetaminophen; Animals; Fatty Liver; Female; Galactose; Lethal Dose 50; Liver; Necrosis; Prothrombin | 1981 |
Effect of high fat diet on liver microsomal oxygenations in ferret.
Topics: Acetaminophen; Animal Feed; Animals; Blotting, Western; Cytochrome P-450 Enzyme System; Dietary Fats | 1994 |
Increased hepatic sensitivity to paracetamol.
Topics: Acetaminophen; Back Pain; Fatty Liver; Humans; Male; Middle Aged | 1978 |
Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Amanita; Autopsy; Brain Edema; Drug Hypersensit | 1975 |
[Drug-induced liver diseases].
Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; C | 1975 |
Circuitry and technique of extracorporeal porcine liver perfusion for the treatment of hepatic coma.
Topics: Acetaminophen; Acute Disease; Animals; Extracorporeal Circulation; Fatty Liver; Hepatic Encephalopat | 1971 |
Extracorporeal perfusion of pig liver in the treatment of acute liver failure.
Topics: Acetaminophen; Adult; Animals; Bilirubin; Brain; Chemical and Drug Induced Liver Injury; Electroence | 1971 |