acetaminophen has been researched along with Liver Diseases in 462 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigates the involvement of liver dysfunction in the modulation of paracetamol pharmacokinetic profile in genotype-4 HCV patients treated with either paracetamol alone (Para) or in combination with caffeine (Para-Caf)." | 9.22 | Bioavailability of paracetamol with/without caffeine in Egyptian patients with hepatitis C virus. ( Abdel-Aziz, AA; Ashour, AA; Atta, R; Botros, SS; El-Lakkany, NM; Hendawy, AS; Mansour, AM; Seif El-Din, SH, 2016) |
| "The optimal route and duration of administration for N-acetyl-cysteine in the management of acetaminophen (paracetamol) poisoning are controversial." | 8.80 | Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? ( Buckley, NA; Dawson, AH; O'Connell, DL; Whyte, IM, 1999) |
| "Here we present the case of a cystic fibrosis (CF) patient with preserved pulmonary function who developed acute liver failure requiring liver transplant following an episode of binge drinking and ingestion of a modest amount of acetaminophen." | 8.31 | Acute Liver Failure Triggered by Therapeutic Dose of Acetaminophen in a Patient with Cystic Fibrosis. ( Goodman, A; Grenn, EE; Koller, FL; Petrasek, J, 2023) |
| "Acute kidney injury (AKI) occurs in 2-10% of patients with acetaminophen (APAP) overdose." | 7.83 | Incidence and characterization of acute kidney injury after acetaminophen overdose. ( Rice, TW; Stollings, JL; Wheeler, AP, 2016) |
| "During the 10-year interval, 1543 patients were hospitalized for acetaminophen overdose; 34% were alcohol abusers, 3% had liver disease, and 13% overdosed unintentionally." | 7.74 | Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose. ( Dean, S; Li, B; Myers, RP; Quan, H; Shaheen, AA, 2008) |
| "An overdose of acetaminophen (APAP) (N-acetyl-p-aminophenol) leads to hepatocellular necrosis induced by its metabolite N-acetyl-p-benzoquinone-imine, which is generated during the metabolic phase of liver intoxication." | 7.73 | Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. ( Apostolov, EO; Basnakian, AG; Mannherz, HG; Napirei, M, 2006) |
| " Both patients were chronic alcohol abusers and had taken therapeutic doses of acetaminophen for a couple of days." | 7.71 | [Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver]. ( Janssens, AR; van Mil, AH, 2001) |
| "It is often taught that acetaminophen-induced liver dysfunction occurs only after a latent period of 24 to 48 hours." | 7.69 | The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. ( Carracio, TR; Mofenson, HC; Singer, AJ, 1995) |
| "The relationship between serum aminotransferase levels and the acute hepatic necrosis induced by acetaminophen was studied in 24 male Wistar rats (220-265 g)." | 7.69 | Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats. ( Collares, EF; De-Santi-Neto, D; Hessel, G, 1996) |
| "This is the fourth reported case of acute pancreatitis associated with acetaminophen overdose." | 7.68 | Acetaminophen induced pancreatitis. ( Caraccio, TR; Mofenson, HC; Nawaz, H; Steckler, G, 1991) |
| " After 10 days of feeding acetaminophen was administered intraperitoneally in amounts known to induce liver necrosis (500 mg/kg)." | 7.67 | Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice. ( Boroujerdi, M; Carlo, JR; Rosenbaum, SE, 1984) |
| "A 63-year-old man with acute psittacosis had severe hepatic damage after ingesting about 10 g of acetaminophen over a 48 hour period." | 7.66 | Severe hepatic damage after acetaminophen use in psittacosis. ( Davis, AM; Helms, CM; LaBrecque, DR; Mitros, FA; Wong, YW, 1983) |
| "In an attempt to elucidate the biochemical mechanism of acetaminophen-induced hepatic necrosis, the present study in hamsters was undertaken to evaluate the possible changes in lipid peroxidation and microsomal enzyme activities." | 7.66 | Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection. ( Bhakthan, NM; Chiu, S, 1978) |
| "60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 7.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 6.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| " These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 5.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
| "Acetaminophen is generally regarded as a safe antipyretic and analgetic agent and is widely used in cases of pregnancy." | 5.22 | Hepatic failure with fatal outcome during pregnancy following administration of a single therapeutic dose of acetominophen: Case report and literature review. ( Gao, Y; Huang, Y; Liang, H; Zhang, R, 2022) |
| "This study investigates the involvement of liver dysfunction in the modulation of paracetamol pharmacokinetic profile in genotype-4 HCV patients treated with either paracetamol alone (Para) or in combination with caffeine (Para-Caf)." | 5.22 | Bioavailability of paracetamol with/without caffeine in Egyptian patients with hepatitis C virus. ( Abdel-Aziz, AA; Ashour, AA; Atta, R; Botros, SS; El-Lakkany, NM; Hendawy, AS; Mansour, AM; Seif El-Din, SH, 2016) |
| " This review summarises the evidence for potential therapeutic applications of non-immunosuppressive cyclophilin inhibitors, alone or in combination with other agents, in virus-induced liver diseases like hepatitis C, B or Delta, liver inflammation and fibrosis, acetaminophen-induced liver toxicity and hepatocellular carcinoma." | 4.90 | Cyclophilin inhibition as potential therapy for liver diseases. ( Naoumov, NV, 2014) |
| "The optimal route and duration of administration for N-acetyl-cysteine in the management of acetaminophen (paracetamol) poisoning are controversial." | 4.80 | Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? ( Buckley, NA; Dawson, AH; O'Connell, DL; Whyte, IM, 1999) |
| "Here we present the case of a cystic fibrosis (CF) patient with preserved pulmonary function who developed acute liver failure requiring liver transplant following an episode of binge drinking and ingestion of a modest amount of acetaminophen." | 4.31 | Acute Liver Failure Triggered by Therapeutic Dose of Acetaminophen in a Patient with Cystic Fibrosis. ( Goodman, A; Grenn, EE; Koller, FL; Petrasek, J, 2023) |
| " Finally, PiTMaP was applied to two cases: (1) an acetaminophen-induced acute liver injury model and control mice and (2) human meningioma samples with different grades (G1-G3), demonstrating the feasibility of PiTMaP." | 3.96 | PiTMaP: A New Analytical Platform for High-Throughput Direct Metabolome Analysis by Probe Electrospray Ionization/Tandem Mass Spectrometry Using an R Software-Based Data Pipeline. ( Eguchi, S; Iguchi, A; Ishii, A; Kawamata, T; Kondo, K; Ohara, T; Tsuchihashi, H; Zaitsu, K, 2020) |
| "Acute kidney injury (AKI) occurs in 2-10% of patients with acetaminophen (APAP) overdose." | 3.83 | Incidence and characterization of acute kidney injury after acetaminophen overdose. ( Rice, TW; Stollings, JL; Wheeler, AP, 2016) |
| " We utilized acetaminophen (APAP) as a model hepatotoxicant that gives a multifocal pattern of necrosis following toxic doses." | 3.74 | Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations. ( Boorman, GA; Flagler, ND; Foley, JF; Heinloth, AN; Paules, RS, 2007) |
| "To determine if subjects with chronic alcoholism are predisposed to acetaminophen-induced hepatotoxicity, and to determine the contributing factors." | 3.74 | Acetaminophen usage patterns and concentrations of glutathione and gamma-glutamyl transferase in alcoholic subjects. ( Anderson, DC; Seifert, CF, 2007) |
| "During the 10-year interval, 1543 patients were hospitalized for acetaminophen overdose; 34% were alcohol abusers, 3% had liver disease, and 13% overdosed unintentionally." | 3.74 | Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose. ( Dean, S; Li, B; Myers, RP; Quan, H; Shaheen, AA, 2008) |
| "An overdose of acetaminophen (APAP) (N-acetyl-p-aminophenol) leads to hepatocellular necrosis induced by its metabolite N-acetyl-p-benzoquinone-imine, which is generated during the metabolic phase of liver intoxication." | 3.73 | Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. ( Apostolov, EO; Basnakian, AG; Mannherz, HG; Napirei, M, 2006) |
| "To investigate the expression and activity of NAD(P)H quinone oxidoreductase 1 (NQO1) in human liver specimens obtained from patients with liver damage due to acetaminophen (APAP) overdose or primary biliary cirrhosis (PBC)." | 3.73 | Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury. ( Aleksunes, LM; Goedken, M; Manautou, JE, 2006) |
| "Hypophosphatemia is frequently observed in acetaminophen-induced hepatotoxicity and may be involved in the pathogenesis of hepatic failure." | 3.71 | Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity. ( Dalhoff, K; Schmidt, LE, 2002) |
| " Both patients were chronic alcohol abusers and had taken therapeutic doses of acetaminophen for a couple of days." | 3.71 | [Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver]. ( Janssens, AR; van Mil, AH, 2001) |
| "It is often taught that acetaminophen-induced liver dysfunction occurs only after a latent period of 24 to 48 hours." | 3.69 | The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. ( Carracio, TR; Mofenson, HC; Singer, AJ, 1995) |
| "We have analysed Kupffer cell and 'activated' perisinusoidal cell populations in liver biopsies from patients with paracetamol (acetaminophen)-induced hepatic necrosis of varying degrees of severity." | 3.69 | Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. ( Burt, AD; Hines, JE; James, OF; Mathew, J, 1994) |
| "The relationship between serum aminotransferase levels and the acute hepatic necrosis induced by acetaminophen was studied in 24 male Wistar rats (220-265 g)." | 3.69 | Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats. ( Collares, EF; De-Santi-Neto, D; Hessel, G, 1996) |
| "This is the fourth reported case of acute pancreatitis associated with acetaminophen overdose." | 3.68 | Acetaminophen induced pancreatitis. ( Caraccio, TR; Mofenson, HC; Nawaz, H; Steckler, G, 1991) |
| "This is the third case reported of maternal acetaminophen overdose during pregnancy." | 3.68 | Can acetaminophen excess result in maternal and fetal toxicity? ( Kurzel, RB, 1990) |
| " After 10 days of feeding acetaminophen was administered intraperitoneally in amounts known to induce liver necrosis (500 mg/kg)." | 3.67 | Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice. ( Boroujerdi, M; Carlo, JR; Rosenbaum, SE, 1984) |
| " The entire spectrum of alcoholic liver disease, including alcoholic hepatitis, may be perfectly mimicked by severe obesity, diabetes, and perhexiline maleate toxicity." | 3.67 | Problems in the necropsy diagnosis of alcoholic liver disease. ( Pounder, DJ, 1984) |
| "We report a case of fulminant hepatic necrosis occurring in the setting of acetaminophen overdose and chronic alcohol use." | 3.67 | Long-term sequellae of acetaminophen-associated fulminant hepatic failure: relevance of early histology. ( Baeg, NJ; Bodenheimer, HC; Burchard, K, 1988) |
| "A 63-year-old man with acute psittacosis had severe hepatic damage after ingesting about 10 g of acetaminophen over a 48 hour period." | 3.66 | Severe hepatic damage after acetaminophen use in psittacosis. ( Davis, AM; Helms, CM; LaBrecque, DR; Mitros, FA; Wong, YW, 1983) |
| "In an attempt to elucidate the biochemical mechanism of acetaminophen-induced hepatic necrosis, the present study in hamsters was undertaken to evaluate the possible changes in lipid peroxidation and microsomal enzyme activities." | 3.66 | Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection. ( Bhakthan, NM; Chiu, S, 1978) |
| "60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 3.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
| "Experimental hepatic necrosis was induced in phenobarbital pretreated rats by means of the intraperitoneal administration of an acetaminophen-dimethyl sulfixide (DMSO) mixture." | 3.65 | Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen. ( Hart, FE; Willson, RA, 1977) |
| "The plasma half lives of antipyrine, paracetamol, and lignocaine given by mouth were measured in 23 patients with stable chronic liver diseases of varying severity." | 3.65 | Antipyrine, paracetamol, and lignocaine elimination in chronic liver disease. ( Adjepon-Yamoah, KK; Finlayson, ND; Forrest, JA; Prescott, LF, 1977) |
| "As a consequence of the altered hepatic architecture in advanced liver disease, drug metabolism is modified by changes in pharmacokinetic and pharmacodynamic properties, leading to the appearance of adverse effects and drug interactions and increasing the risk of over- or underdosing of medications." | 2.82 | Management of Pharmacologic Adverse Effects in Advanced Liver Disease. ( García-Cortés, M; García-García, A, 2022) |
| " The level of certainty for dosing recommendations obtainable from reviewing the evidence is low due to a small number of studies meeting search criteria, small samples sizes, inadequate information regarding cirrhosis etiology and compensated versus uncompensated liver disease, and lack of information on patient centered health outcomes." | 2.58 | A Systematic Review of the Evidence Behind Use of Reduced Doses of Acetaminophen in Chronic Liver Disease. ( Juba, KM; Schweighardt, AE, 2018) |
| " Dosage reduction and/or increased dose interval are often required." | 2.52 | [Analgesia in patients with hepatic impairment]. ( Innaurato, G; Piguet, V; Simonet, ML, 2015) |
| "Most anaphylactoid reactions occur at the start of acetylcysteine treatment when concentrations are highest." | 2.45 | Adverse reactions associated with acetylcysteine. ( Bateman, DN; Sandilands, EA, 2009) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 2.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| "Acetaminophen has been widely used for > 50 years in the treatment of pain and fever and provides for the safe and effective relief of these symptoms." | 2.44 | Acetaminophen safety and hepatotoxicity--where do we go from here? ( Amar, PJ; Schiff, ER, 2007) |
| "Acetaminophen poisoning accounts for a disproportionate percentage of all toxic ingestions, and can be life-threatening." | 2.43 | An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children. ( Marzullo, L, 2005) |
| "The currently recommended dosing scheme for treating acetaminophen overdose in the United States consists of a loading dose of oral N-acetylcysteine 140 mg/kg, followed by 70 mg/kg every 4 hours for 17 doses, for a total of 72 hours of oral N-acetylcysteine therapy." | 2.42 | Acetaminophen intoxication and length of treatment: how long is long enough? ( Kociancic, T; Reed, MD, 2003) |
| "Acetaminophen did not cause hepatic lipid peroxidation in wild-type mice but did cause lipid peroxidation in iNOS knockout mice." | 2.42 | Acetaminophen-induced hepatotoxicity. ( Hinson, JA; James, LP; Mayeux, PR, 2003) |
| "Clinical descriptions of fulminant hepatic failure as originally reported, along with the subgroups of subfulminant and late onset hepatic failure identified later, are considered in relation to the proposed new classification of hyperacute, acute, and subacute liver failure." | 2.39 | Classification, etiology, and considerations of outcome in acute liver failure. ( Williams, R, 1996) |
| " It was a prerequisite to establish the bioavailability of oxazepam prior to succeeding studies on the oral disposition of the drug." | 2.38 | Factors and conditions affecting the glucuronidation of oxazepam. ( Sonne, J, 1993) |
| " The possible causes for the injury from ostensibly nontoxic drug levels appear to be either the induction by chronic alcohol intake of the cytochrome P-450 system responsible for converting acetaminophen to a toxic metabolite, or the effect of alcoholism and the associated malnutrition in reducing the glutathione concentration, responsible normally for preventing hepatotoxicity by conjugation with the toxic metabolite." | 2.37 | Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. ( Adler, E; Benjamin, SB; Cuccherini, BA; Seeff, LB; Zimmerman, HJ, 1986) |
| " In a double-blind, two-week, cross-over study, no clinical or laboratory evidence of adverse effects was found." | 2.36 | Hepatotoxicity following the therapeutic use of antipyretic analgesics. ( Benson, GD, 1983) |
| " In mice, acute liver injury induced by orally dosing APAP (500 mg/kg) was severely exacerbated by Gpbar1 gene ablation and attenuated by anti-Cysltr1 small interfering RNA pretreatment." | 1.91 | Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury. ( Bellini, R; Biagioli, M; Bordoni, M; Cassiano, C; Catalanotti, B; di Giorgio, C; Distrutti, E; Fiorillo, B; Fiorucci, S; Marchianò, S; Monti, MC; Roselli, R; Sepe, V; Zampella, A, 2023) |
| "The pandemic of coronavirus disease 2019 (COVID-19) has emerged as a relevant threat for humans worldwide." | 1.56 | Abnormal liver function tests predict transfer to intensive care unit and death in COVID-19. ( Angeli, P; Benfaremo, D; Cattelan, A; Cerruti, L; Dalbeni, A; Framba, V; Gambino, CG; Luchetti, MM; Mantovani, A; Martini, A; Mattioli, M; Piano, S; Serra, R; Vettor, R; Vettore, E, 2020) |
| " (MO) extracts and its curative role in acetaminophen (APAP)-induced toxic liver injury in rats caused by oxidative damage." | 1.38 | Moringa oleifera hydroethanolic extracts effectively alleviate acetaminophen-induced hepatotoxicity in experimental rats through their antioxidant nature. ( Arulselvan, P; Fakurazi, S; Sharifudin, SA, 2012) |
| " For studies of toxic processes, 1H NMR spectroscopy of biofluids allows monitoring of endogenous metabolite profiles that alter characteristically in response to changes in physiological status." | 1.37 | A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity. ( Ando, Y; Fukuhara, K; Ohno, A; Okuda, H; Yamoto, T, 2011) |
| " Toxicity, pharmacokinetics and clinical bioavailability of resveratrol are also reviewed in this article." | 1.36 | Resveratrol and liver disease: from bench to bedside and community. ( Bishayee, A; Darvesh, AS; McGory, R; Politis, T, 2010) |
| " A dose-response study showed that the accumulation of long-chain acylcarnitines in serum contributes to the separation of wild-type mice undergoing APAP-induced hepatotoxicity from other mouse groups in a multivariate model." | 1.35 | Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. ( Chen, C; Gonzalez, FJ; Idle, JR; Krausz, KW; Shah, YM, 2009) |
| "Acetaminophen (APAP) is safe at therapeutic levels but causes hepatotoxicity via N-acetyl-p-benzoquinone imine-induced oxidative stress upon overdose." | 1.35 | Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. ( Cheng, J; Gonzalez, FJ; Idle, JR; Krausz, KW; Ma, X, 2009) |
| "Paracetamol poisoning is a major health problem worldwide." | 1.35 | Limiting paracetamol pack size: has it worked in the UK? ( Bateman, DN, 2009) |
| " Prazosin prevented hepatotoxicity when administered 1 h before a toxic paracetamol insult and importantly, when administered up to 1 h post paracetamol injection." | 1.35 | alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice. ( Kitteringham, NR; Macdonald, I; Park, BK; Randle, LE; Sathish, JG; Williams, DP, 2008) |
| " Mice were administered a diet supplemented with GrTP or vehicle for 5 consecutive days followed by intraperitoneal (IP) injection of a toxic dose of APAP or sham." | 1.35 | Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity. ( Chen, TS; Oz, HS, 2008) |
| " The principal component analysis (PCA) of NMR or UPLC/MS spectra showed that metabolic changes observed in both acute and chronic dosing of acetaminophen were similar." | 1.35 | Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. ( Beger, RD; Cantor, GH; Dragan, YP; Holland, RD; Schmitt, TC; Schnackenberg, LK; Sun, J, 2008) |
| "Acetaminophen (APAP) is a widely-used analgesic and a known hepatotoxic agent." | 1.34 | VEGF isoforms and receptors expression throughout acute acetaminophen-induced liver injury and regeneration. ( Bartsocas, CS; Bozas, E; Garyfallidis, S; Grypioti, A; Mykoniatis, MG; Nicolopoulou-Stamati, P; Papastefanou, VP, 2007) |
| "Although used widely and recognized as a safe drug at therapeutic dose, acetaminophen has a narrow therapeutic margin." | 1.34 | [Acetaminophen: hepatotoxicity at therapeutic doses and risk factors]. ( Hadengue, A; Iten, A; Seirafi, M, 2007) |
| "Acetaminophen injury was followed by periportal oval cell accumulation displaying a moderate degree of morphological homogeneity." | 1.33 | Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury. ( Hussain, M; Kirschenbaum, A; Kofman, AV; Morgan, G; Osbeck, J; Swenson, S; Theise, ND, 2005) |
| " The administration of a toxic dose of acetaminophen (3." | 1.33 | Platelet-activating factor (PAF) involvement in acetaminophen-induced liver toxicity and regeneration. ( Basayiannis, AC; Demopoulos, CA; Grypioti, AD; Mykoniatis, MG; Papadimas, GK; Papadopoulou-Daifoti, Z; Theocharis, SE, 2005) |
| " paludosa pretreatment (100-500 mg kg(-1)) in a dose-response manner." | 1.33 | Protective effect of crude extract from Wedelia paludosa (Asteraceae) on the hepatotoxicity induced by paracetamol in mice. ( Bagio, A; Balz, D; Brocardo, PS; Dafre, AL; Goulart, EC; Meotti, FC; Rodrigues, AL; Rosa, JM; Santos, AR; Waltrick, AP, 2006) |
| "Accidental or incidental paracetamol overdose in children may be associated with toxic liver damage leading to fulminant liver failure." | 1.33 | Paracetamol induced hepatotoxicity. ( Davies, P; Kelly, DA; Mahadevan, SB; McKiernan, PJ, 2006) |
| "The mean Cmax of 11." | 1.33 | The pharmacokinetics of a single rectal dose of paracetamol (40 mg x kg(-1)) in children with liver disease. ( Addison, R; Ashley, EM; Cormack, CR; Howell, T; Keating, J; Sherwood, RA; Sudan, S, 2006) |
| "Severe injury to the liver, such as that induced by toxic doses of acetaminophen, triggers a cascade of events leading to hepatocyte death." | 1.33 | Blockade of the receptor for advanced glycation end products attenuates acetaminophen-induced hepatotoxicity in mice. ( Dun, H; Ekong, U; Emond, JC; Feirt, N; Guarrera, JV; Guo, J; Ippagunta, N; Lu, Y; Qu, W; Ramasamy, R; Schmidt, AM; Weinberg, A; Zeng, S, 2006) |
| " The protection afforded by V-PYRRO/NO does not appear to be caused by a decrease in the formation of toxic acetaminophen metabolites, which consumes glutathione (GSH), because V-PYRRO/NO did not alter acetaminophen-induced hepatic GSH depletion." | 1.32 | The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice. ( Clark, J; Keefer, LK; Li, C; Liu, J; Myers, P; Saavedra, JE; Waalkes, MP, 2003) |
| " To determine the importance of reversible versus toxic events, N-acetylcysteine (NAC) was administered to mice either before APAP or 1, 2, or 4 h after APAP." | 1.32 | Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. ( Hinson, JA; James, LP; Lamps, LW; McCullough, SS, 2003) |
| "Acetaminophen, a safe analgesic when dosed properly but hepatotoxic at overdoses, has been reported to induce DNA strand breaks but it is unclear whether this event preceeds hepatocyte toxicity or is only obvious in case of overt cytotoxicity." | 1.32 | Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity. ( El-Bahay, C; Hanelt, S; Kahl, R; Lewerenz, V; Nastevska, C; Röhrdanz, E, 2003) |
| " The protection offered by arabic gum does not appear to be caused by a decrease in the formation of toxic acetaminophen metabolites, which consumes glutathione, because arabic gum did not alter acetaminophen-induced hepatic glutathione depletion." | 1.32 | Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice. ( Al-Bekairi, AM; Al-Shabanah, OA; Gamal el-din, AM; Mostafa, AM; Nagi, MN, 2003) |
| "Acetaminophen may increase International Normalized Ratio (INR) in patients taking anticoagulation medication, and in patients with acetaminophen poisoning without hepatic injury." | 1.31 | Acetaminophen causes an increased International Normalized Ratio by reducing functional factor VII. ( Buckley, NA; Dawson, AH; Goodhew, I; Reith, DM; Seldon, M; Whyte, IM, 2000) |
| "Taurine (200 mg/kg) was given 12 h before, at the time of, and 1 or 2 h after acetaminophen injection." | 1.31 | Role of taurine in preventing acetaminophen-induced hepatic injury in the rat. ( Bouchier-Hayes, D; Kay, E; Redmond, HP; Wang, JH; Waters, E; Wu, QD, 2001) |
| " The results of these studies demonstrated that CS-mediated protection is not selective for a particular species, organ system or toxic chemical." | 1.30 | Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine. ( Fariss, MW; Lippman, HR; Mumaw, VR; Ray, SD, 1997) |
| " When PEITC (19-150 micromol/kg) was given to mice intragastrically 1 hr before or immediately prior to a toxic dose of APAP, the APAP-induced hepatotoxicity was significantly decreased or was completely prevented." | 1.30 | Effects of phenethyl isothiocyanate on acetaminophen metabolism and hepatotoxicity in mice. ( Chen, L; Li, Y; Reuhl, KR; Stein, AP; Wang, EJ; Yang, CS, 1997) |
| "A higher frequency of chronic alcohol abuse among the patients with accidental overdoses may be one explanation." | 1.30 | Acetaminophen toxicity in an urban county hospital. ( Casey, DL; Lee, WM; Rochling, FA; Schiødt, FV, 1997) |
| "We report a case fatality from chronic acetaminophen (APAP) toxicity in an 18-month-old toddler, born 14 weeks premature, who had been receiving less than the standard toxic threshold of the pediatric suspension of APAP for 4 days prior to presentation." | 1.30 | "The silent killer": chronic acetaminophen toxicity in a toddler. ( King, W; Nichols, M; Pershad, J, 1999) |
| " We have developed a mouse model to demonstrate the toxic effects of methotrexate: mice were given 50 mg/kg acetaminophen, which itself has no effect on the liver." | 1.30 | Nicotinamide and methionine reduce the liver toxic effect of methotrexate. ( Bache, K; Hauschild, A; Kröger, H; Krüger, D; Ohde, M; Thefeldt, W; Voigt, WP, 1999) |
| " These results suggest that ethanol inhibited not only the microsomal (CYP2E1 mediated) formation of a toxic quinone metabolite from APAP, but also accelerated the conversion of the toxic quinone metabolite produced back to APAP by stimulating cytoplasmic QR activity." | 1.30 | Protective effect of ethanol against acetaminophen-induced hepatotoxicity in mice: role of NADH:quinone reductase. ( Cha, YN; Cho, TS; Kim, DJ; Lee, SM, 1999) |
| "Acetaminophen was administered at a dose of 650 mg/kg body weight (intraperitoneally) to fasted male Long Evans rats." | 1.29 | Acetaminophen-induced microvascular injury in the rat liver: protection with misoprostol. ( Andrews, FJ; Lim, SP; O'Brien, PE, 1995) |
| " stocksianum did not produce any lethality or adverse effects in the livers of treated mice." | 1.29 | Effect of Teucrium stocksianum on paracetamol-induced hepatotoxicity in mice. ( Ali, BH; Bashir, AK; Rasheed, RA, 1995) |
| " PSP did not reverse the depletion of total glutathione (GSH+GSSG) by the toxic dose of paracetamol." | 1.29 | Effect of polysaccharide peptide (PSP) on glutathione and protection against paracetamol-induced hepatotoxicity in the rat. ( Chiu, LC; Ooi, VE; Yeung, JH, 1994) |
| "Caffeine was a competitive inhibitor of APAP bioactivation in microsomes from beta NF- and acetone-treated mice." | 1.29 | Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents. ( Jaw, S; Jeffery, EH, 1993) |
| "Oleanolic acid (OA) is a triterpenoid compound that has been shown to protect against a number of hepatotoxicants, and is used in China to treat hepatitis." | 1.29 | Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice. ( Klaassen, CD; Liu, J; Liu, Y; Madhu, C, 1993) |
| "3 min of half-life of hepatic uptake) when compared with the control group (15." | 1.29 | Plasma-kallikrein clearance by the liver of acetaminophen-intoxicated rats. ( Borges, DR; de Toledo, CF, 1993) |
| " In the initial 3-week dose-response study, as the daily dose of VA increased so did the degree of potentiation of CCl4 hepatotoxicity." | 1.29 | Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury. ( Earnest, DL; elSisi, AE; Hall, P; Sim, WL; Sipes, IG, 1993) |
| "Research into the pathogenesis of acetaminophen (paracetamol)-induced hepatotoxicity has concentrated on the generation of toxic metabolites by the hepatocytes." | 1.29 | Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity. ( Breach, CS; Brown, IN; Goldin, RD; Ratnayaka, ID; Wickramasinghe, SN, 1996) |
| "0 mmol/kg) alone were toxic to mice induced with benzo(a)pyrene but not to control or phenobarbitone-induced mice." | 1.28 | Cysteine isopropylester protects against paracetamol-induced toxicity. ( Butterworth, M; Cohen, GM; Smith, LL; Upshall, DG, 1992) |
| "Buthionine sulfoximine is used to inactivate glutathione synthesis, and small increments of acetaminophen are given intravenously to maintain the plasma level at approximately 200 micrograms/ml for 20 hr." | 1.28 | An improved model of acetaminophen-induced fulminant hepatic failure in dogs. ( Chong, MG; He, DE; Kelly, JH; Koussayer, T; Shang, TA; Sussman, NL; Whisennand, HH, 1992) |
| "Acetaminophen bioactivation was quantified by production of the glutathione-derived cysteine and mercapturic acid conjugates of acetaminophen." | 1.28 | Biphasic modulation of acetaminophen bioactivation and hepatotoxicity by pretreatment with the interferon inducer polyinosinic-polycytidylic acid. ( Kalabis, GM; Wells, PG, 1990) |
| "The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase." | 1.28 | Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis? ( Ben-Zvi, Z; Danon, A; Katz, S; Weissman-Teitellman, B, 1990) |
| " Analysis of the actually reported and the computer-assisted predicted data has shown that the computer-assisted predictive formula may be clinically helpful in determining if the plasma acetaminophen level is in the toxic or nontoxic range." | 1.28 | Computer-assisted predictive mathematical relationship among plasma acetaminophen concentration and time and hepatotoxicity in man. ( Chung, SJ, 1989) |
| " We conclude that, although propranolol may have some influence on drug handling acutely, chronic administration does not interfere with hepatic drug metabolism or renal drug clearance." | 1.28 | Effect of acute and chronic propranolol administration on antipyrine and paracetamol clearance in patients with chronic liver disease. ( Bouchier, IA; Hayes, PC, 1989) |
| "142) were found to protect mice against the hepatotoxicity of paracetamol, which is due to cytochrome P-450 dependent formation of toxic metabolites and radicals." | 1.28 | In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity. ( Delaforge, M; Jaouen, M; Jollès, P; Mansuy, D; Migliore-Samour, D, 1989) |
| "This augmented necrosis is averted by prolonged treatment with hyperbaric oxygen." | 1.27 | Effect of hyperoxia on liver necrosis induced by hepatotoxins. ( Marzella, L; Muhvich, K; Myers, RA, 1986) |
| " While the glutathione conjugating system is enhanced by selenium treatment, amelioration of acetaminophen toxicity is most likely the result of enhanced glucuronidation which effectively diverts the amount of acetaminophen to be converted by the cytochrome P-450 system to the toxic metabolite." | 1.27 | Protective effects of selenium on acetaminophen-induced hepatotoxicity in the rat. ( Davies, MH; Merrick, BA; Park, KS; Schnell, RC; Weir, SW, 1988) |
| " A close correlation between administered dosage of the drug, acetaminophen blood levels and methemoglobinemia was found." | 1.27 | [Paracetamol poisoning in a swine model]. ( Artwohl, J; Dziwisch, L; Henne-Bruns, D; Kremer, B, 1988) |
| " A close correlation between administered dosage of the drug, acetaminophen blood levels, and methemoglobinemia was found." | 1.27 | Acetaminophen-induced acute hepatic failure in pigs: controversical results to other animal models. ( Artwohl, J; Broelsch, C; Henne-Bruns, D; Kremer, B, 1988) |
| " Also, the effect of food deprivation of both the euthyroid and PTU-induced hypothyroid rats for 24 h, as well as forced feeding of the euthyroid rats after a toxic dose of APAP, was determined." | 1.27 | Effect of nutritional status on propylthiouracil-induced protection against acetaminophen hepatotoxicity in the rat. ( Cho, CD; Hirose, N; Raheja, KL, 1987) |
| " Since the major nontoxic pathway (glucuronide) and the toxic pathway (as measured by mercapturate) decreased to a similar extent, the data indicate that the anomalous lack of protection cannot be explained on the basis of altered metabolic disposition of the drug." | 1.27 | Anomalous susceptibility of the fasted hamster to acetaminophen hepatotoxicity. ( Jollow, DJ; Miller, MG; Price, VF, 1986) |
| " These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 1.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
| "Signs of grade 3 hepatic encephalopathy were never found until 72 hours after the overdose, and sudden deterioration in consciousness at an earlier stage was due either to the sedative effects of drugs or to hypoglycaemia, which in one patient went unrecognised for 24 hours." | 1.26 | Factors contributing to mortality in paracetamol-induced hepatic failure. ( Canalese, J; Davis, M; Gimson, AE; Williams, R, 1981) |
| " The hallmark of severe (grade III) damage is centrizonal necrosis, for which there is probably a dosage threshold." | 1.26 | Evaluation of paracetamol-induced damage in liver biopsies. Acute changes and follow-up findings. ( Douglas, AP; Hamlyn, AN; James, OF; Lesna, M; Watson, AJ, 1976) |
| " The plasma half-life of the unchanged drug was significantly prolonged, and the ratio of the plasma concentrations of unchanged to conjugated paracetamol was significantly higher than in the patients without liver damage." | 1.25 | The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. ( Prescott, LF; Wright, N, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 125 (27.06) | 18.7374 |
| 1990's | 108 (23.38) | 18.2507 |
| 2000's | 175 (37.88) | 29.6817 |
| 2010's | 32 (6.93) | 24.3611 |
| 2020's | 22 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Dayasiri, K | 1 |
| Rao, S | 1 |
| Watanabe, T | 1 |
| Takada, S | 1 |
| Onozato, M | 1 |
| Fukushima, T | 1 |
| Mizuta, R | 1 |
| García-Cortés, M | 1 |
| García-García, A | 1 |
| Feki, F | 1 |
| Mahmoudi, A | 1 |
| Denev, P | 1 |
| Feki, I | 1 |
| Ognyanov, M | 1 |
| Georgiev, Y | 1 |
| Choura, S | 1 |
| Chamkha, M | 1 |
| Trendafilova, A | 1 |
| Sayadi, S | 1 |
| Kang, S | 1 |
| Bo, Y | 1 |
| Yang, D | 1 |
| Wu, G | 2 |
| Yang, X | 1 |
| Wei, J | 1 |
| Zhao, G | 1 |
| An, M | 1 |
| Zhao, L | 1 |
| Biagioli, M | 1 |
| Marchianò, S | 1 |
| di Giorgio, C | 1 |
| Roselli, R | 1 |
| Bordoni, M | 1 |
| Bellini, R | 1 |
| Fiorillo, B | 1 |
| Sepe, V | 1 |
| Catalanotti, B | 1 |
| Cassiano, C | 1 |
| Monti, MC | 1 |
| Distrutti, E | 1 |
| Zampella, A | 1 |
| Fiorucci, S | 1 |
| Gao, Y | 2 |
| Zhang, R | 1 |
| Liang, H | 1 |
| Huang, Y | 1 |
| Hassan, R | 1 |
| González, D | 1 |
| Hobloss, Z | 1 |
| Brackhagen, L | 1 |
| Myllys, M | 1 |
| Friebel, A | 1 |
| Seddek, AL | 1 |
| Marchan, R | 1 |
| Cramer, B | 1 |
| Humpf, HU | 1 |
| Hoehme, S | 1 |
| Degen, GH | 1 |
| Hengstler, JG | 1 |
| Ghallab, A | 1 |
| Oğuz Cumaoğlu, M | 1 |
| Cumaoğlu, B | 1 |
| Tekin, Y | 1 |
| Günay, N | 1 |
| González-Recio, I | 3 |
| Simón, J | 3 |
| Goikoetxea-Usandizaga, N | 3 |
| Serrano-Maciá, M | 3 |
| Mercado-Gómez, M | 3 |
| Rodríguez-Agudo, R | 3 |
| Lachiondo-Ortega, S | 3 |
| Gil-Pitarch, C | 3 |
| Fernández-Rodríguez, C | 3 |
| Castellana, D | 3 |
| Latasa, MU | 3 |
| Abecia, L | 3 |
| Anguita, J | 3 |
| Delgado, TC | 3 |
| Iruzubieta, P | 3 |
| Crespo, J | 3 |
| Hardy, S | 3 |
| Petrov, PD | 3 |
| Jover, R | 3 |
| Avila, MA | 3 |
| Martín, C | 3 |
| Schaeper, U | 3 |
| Tremblay, ML | 3 |
| Dear, JW | 3 |
| Masson, S | 3 |
| McCain, MV | 3 |
| Reeves, HL | 3 |
| Andrade, RJ | 3 |
| Lucena, MI | 3 |
| Buccella, D | 3 |
| Martínez-Cruz, LA | 3 |
| Martínez-Chantar, ML | 3 |
| Hwang, KA | 2 |
| Hwang, Y | 2 |
| Hwang, HJ | 2 |
| Park, N | 2 |
| Guo, F | 1 |
| Li, X | 2 |
| Lei, X | 1 |
| Zheng, J | 1 |
| Yang, N | 1 |
| Wan, Y | 1 |
| Cheng, W | 1 |
| Zhang, G | 1 |
| Yu, S | 1 |
| Yang, B | 1 |
| Liu, X | 1 |
| Chen, X | 1 |
| Ding, X | 1 |
| Wu, L | 1 |
| Yu, X | 1 |
| Ishida, Y | 4 |
| Zhang, S | 2 |
| Kuninaka, Y | 1 |
| Ishigami, A | 1 |
| Nosaka, M | 1 |
| Harie, I | 1 |
| Kimura, A | 3 |
| Mukaida, N | 4 |
| Kondo, T | 4 |
| Holzhütter, HG | 1 |
| Wuensch, T | 1 |
| Gajowski, R | 1 |
| Berndt, N | 1 |
| Bulik, S | 1 |
| Meierhofer, D | 1 |
| Stockmann, M | 1 |
| Zaitsu, K | 1 |
| Eguchi, S | 1 |
| Ohara, T | 1 |
| Kondo, K | 1 |
| Ishii, A | 1 |
| Tsuchihashi, H | 1 |
| Kawamata, T | 1 |
| Iguchi, A | 1 |
| Piano, S | 1 |
| Dalbeni, A | 1 |
| Vettore, E | 1 |
| Benfaremo, D | 1 |
| Mattioli, M | 1 |
| Gambino, CG | 1 |
| Framba, V | 1 |
| Cerruti, L | 1 |
| Mantovani, A | 1 |
| Martini, A | 1 |
| Luchetti, MM | 1 |
| Serra, R | 1 |
| Cattelan, A | 1 |
| Vettor, R | 1 |
| Angeli, P | 1 |
| Lajtai, A | 1 |
| Lakatos, Á | 1 |
| Kuzma, M | 1 |
| Mayer, M | 1 |
| Miseta, A | 1 |
| Jiwa, A | 1 |
| Jakes, AD | 1 |
| Banerjee, A | 1 |
| Kresnamurti, A | 1 |
| Rakhma, DN | 1 |
| Damayanti, A | 1 |
| Santoso, SD | 1 |
| Restryarto, E | 1 |
| Hadinata, W | 1 |
| Hamid, IS | 1 |
| Weinberg, L | 1 |
| Chiam, E | 1 |
| Karp, J | 1 |
| Churilov, L | 1 |
| Bellomo, R | 1 |
| Goodman, A | 1 |
| Grenn, EE | 1 |
| Koller, FL | 1 |
| Petrasek, J | 1 |
| Wong, A | 1 |
| Sivilotti, MLA | 1 |
| Gunja, N | 1 |
| McNulty, R | 1 |
| Graudins, A | 2 |
| Atteya, M | 1 |
| Ahmed, AM | 1 |
| AlRabiah, A | 1 |
| Al-Matrafi, TA | 1 |
| Arafah, MM | 1 |
| Al-Saggaf, S | 1 |
| Shereef, SH | 1 |
| Ahmed, AAH | 1 |
| Alqahtani, HM | 1 |
| Mohammad, RAT | 1 |
| Gebreselassie, A | 1 |
| Aduli, F | 1 |
| Howell, CD | 1 |
| Park, MJ | 1 |
| D'Alecy, LG | 1 |
| Anderson, MA | 1 |
| Basrur, V | 1 |
| Feng, Y | 1 |
| Brady, GF | 1 |
| Kim, DI | 1 |
| Wu, J | 1 |
| Nesvizhskii, AI | 1 |
| Lahann, J | 1 |
| Lukacs, NW | 2 |
| Fontana, RJ | 1 |
| Omary, MB | 1 |
| Andersen, PE | 1 |
| Svart, M | 1 |
| Schweighardt, AE | 1 |
| Juba, KM | 1 |
| Tan, J | 1 |
| Li, J | 2 |
| Ma, J | 1 |
| Qiao, F | 1 |
| Liu, LY | 1 |
| Fox, CS | 1 |
| North, TE | 1 |
| Goessling, W | 1 |
| Hong, H | 1 |
| Tong, W | 1 |
| Naoumov, NV | 1 |
| Ioannides, SJ | 1 |
| Siebers, R | 1 |
| Perrin, K | 1 |
| Weatherall, M | 1 |
| Crane, J | 1 |
| Travers, J | 1 |
| Shirtcliffe, P | 1 |
| Beasley, R | 1 |
| Innaurato, G | 1 |
| Piguet, V | 1 |
| Simonet, ML | 1 |
| Murray, TV | 1 |
| Dong, X | 1 |
| Sawyer, GJ | 1 |
| Caldwell, A | 1 |
| Halket, J | 1 |
| Sherwood, R | 1 |
| Quaglia, A | 1 |
| Dew, T | 1 |
| Anilkumar, N | 1 |
| Burr, S | 1 |
| Mistry, RK | 1 |
| Martin, D | 1 |
| Schröder, K | 1 |
| Brandes, RP | 1 |
| Hughes, RD | 5 |
| Shah, AM | 1 |
| Brewer, AC | 1 |
| El-Lakkany, NM | 1 |
| Hendawy, AS | 1 |
| Seif El-Din, SH | 1 |
| Ashour, AA | 1 |
| Atta, R | 1 |
| Abdel-Aziz, AA | 1 |
| Mansour, AM | 1 |
| Botros, SS | 1 |
| Fan, X | 1 |
| Li, D | 1 |
| Zeng, X | 1 |
| Zeng, H | 1 |
| Wang, Y | 1 |
| Zhou, Y | 1 |
| Chen, Y | 1 |
| Huang, M | 1 |
| Bi, H | 1 |
| Siemionow, K | 1 |
| Teul, J | 1 |
| Drągowski, P | 1 |
| Pałka, J | 1 |
| Miltyk, W | 1 |
| Stollings, JL | 1 |
| Wheeler, AP | 1 |
| Rice, TW | 1 |
| Pang, C | 1 |
| Shi, L | 1 |
| Sheng, Y | 1 |
| Zheng, Z | 1 |
| Wei, H | 1 |
| Wang, Z | 1 |
| Ji, L | 1 |
| Olson, KR | 1 |
| Davarpanah, AH | 1 |
| Schaefer, EA | 1 |
| Elias, N | 1 |
| Misdraji, J | 1 |
| Shanmugam, S | 1 |
| Sivaraj, D | 1 |
| Dos Santos Lima, B | 1 |
| Dos Passos Menezes, P | 1 |
| de Carvalho, YMBG | 1 |
| de Souza Araújo, AA | 1 |
| Narain, N | 1 |
| Serafini, MR | 1 |
| Quintans Júnior, LJ | 1 |
| Scotti, L | 1 |
| Scotti, MT | 1 |
| Parimelazhagan, T | 1 |
| Botta, D | 1 |
| White, CC | 1 |
| Vliet-Gregg, P | 1 |
| Mohar, I | 1 |
| Shi, S | 1 |
| McGrath, MB | 1 |
| McConnachie, LA | 1 |
| Kavanagh, TJ | 1 |
| Masson, MJ | 1 |
| Carpenter, LD | 1 |
| Graf, ML | 2 |
| Pohl, LR | 6 |
| Jaeschke, H | 4 |
| Sabir, SM | 1 |
| Rocha, JB | 1 |
| Lai, JT | 1 |
| Fang, HL | 1 |
| Hsieh, WT | 1 |
| Lin, WC | 2 |
| Krishnakumar, NM | 1 |
| Latha, PG | 2 |
| Suja, SR | 1 |
| Shine, VJ | 2 |
| Shyamal, S | 2 |
| Anuja, GI | 1 |
| Sini, S | 1 |
| Pradeep, S | 1 |
| Shikha, P | 1 |
| Unni, PK | 1 |
| Rajasekharan, S | 1 |
| Pakravan, N | 1 |
| Simpson, KJ | 2 |
| Waring, WS | 1 |
| Bates, CM | 1 |
| Bateman, DN | 3 |
| Leiner, S | 1 |
| Ishibe, T | 1 |
| Takayasu, T | 2 |
| Hayashi, T | 1 |
| Tsuneyama, K | 2 |
| Matsushima, K | 1 |
| Sakata, I | 1 |
| Savransky, V | 1 |
| Reinke, C | 1 |
| Jun, J | 1 |
| Bevans-Fonti, S | 1 |
| Nanayakkara, A | 1 |
| Myers, AC | 1 |
| Torbenson, MS | 1 |
| Polotsky, VY | 1 |
| Mottino, AD | 1 |
| Catania, VA | 1 |
| Lavie, L | 1 |
| Rajesh, SV | 1 |
| Rajkapoor, B | 1 |
| Kumar, RS | 1 |
| Raju, K | 1 |
| Wang, K | 1 |
| Marzolf, B | 1 |
| Troisch, P | 1 |
| Brightman, A | 1 |
| Hu, Z | 1 |
| Hood, LE | 1 |
| Galas, DJ | 1 |
| Chen, C | 1 |
| Krausz, KW | 2 |
| Shah, YM | 1 |
| Idle, JR | 2 |
| Gonzalez, FJ | 5 |
| Sandilands, EA | 1 |
| Suzuki, A | 1 |
| Yuen, N | 1 |
| Walsh, J | 1 |
| Papay, J | 1 |
| Hunt, CM | 1 |
| Diehl, AM | 1 |
| Reisman, SA | 1 |
| Buckley, DB | 1 |
| Tanaka, Y | 1 |
| Klaassen, CD | 7 |
| Fernando, WK | 1 |
| Ariyananda, PL | 1 |
| Castanyer, B | 1 |
| Barceló, B | 1 |
| Puiguriguer, J | 1 |
| Nogué, S | 1 |
| Choi, JH | 1 |
| Choi, CY | 1 |
| Lee, KJ | 2 |
| Hwang, YP | 1 |
| Chung, YC | 2 |
| Jeong, HG | 2 |
| Cheng, J | 1 |
| Ma, X | 2 |
| Southey, ER | 1 |
| Soares-Weiser, K | 1 |
| Kleijnen, J | 1 |
| Zanobbio, L | 1 |
| Palazzo, M | 1 |
| Gariboldi, S | 1 |
| Dusio, GF | 1 |
| Cardani, D | 1 |
| Mauro, V | 1 |
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| Balsari, A | 1 |
| Rumio, C | 1 |
| Lopez, DP | 1 |
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| Baravalia, Y | 1 |
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| Laskin, DL | 2 |
| Habdous, M | 1 |
| Vincent-Viry, M | 1 |
| Visvikis, S | 1 |
| Siest, G | 1 |
| Ju, C | 1 |
| Reilly, TP | 5 |
| Bourdi, M | 4 |
| Radonovich, MF | 2 |
| Brady, JN | 2 |
| George, JW | 3 |
| Janbaz, KH | 4 |
| Saeed, SA | 1 |
| Gilani, AH | 4 |
| Wong, F | 1 |
| Greabu, M | 1 |
| Olinescu, R | 1 |
| Li, C | 1 |
| Waalkes, MP | 2 |
| Clark, J | 1 |
| Myers, P | 1 |
| Saavedra, JE | 1 |
| Keefer, LK | 1 |
| Vitols, S | 1 |
| Ghanem, C | 2 |
| Gomez, PC | 1 |
| Arana, C | 1 |
| Bengochea, L | 3 |
| Hori, Y | 1 |
| Iwasaki, Y | 1 |
| Kuroki, Y | 1 |
| Komiyayama, Y | 1 |
| Nakatani, H | 1 |
| Namera, A | 1 |
| Saseen, JJ | 1 |
| Isbister, GK | 1 |
| Downes, F | 1 |
| Whyte, IM | 4 |
| Masubuchi, Y | 2 |
| Gomes, A | 1 |
| Das, M | 1 |
| Sur, P | 1 |
| Besra, SE | 1 |
| Chakravorty, AK | 1 |
| Das, B | 1 |
| Ganguly, DK | 1 |
| Vedasiromoni, JR | 1 |
| Yip, L | 1 |
| Dart, RC | 2 |
| Yanpallewar, SU | 1 |
| Sen, S | 1 |
| Tapas, S | 1 |
| Kumar, M | 1 |
| Raju, SS | 1 |
| Acharya, SB | 1 |
| James, LP | 3 |
| McCullough, SS | 1 |
| Lamps, LW | 1 |
| Hinson, JA | 2 |
| Kociancic, T | 1 |
| Reed, MD | 1 |
| Lipworth, L | 1 |
| Friis, S | 1 |
| Mellemkjaer, L | 1 |
| Signorello, LB | 1 |
| Johnsen, SP | 1 |
| Nielsen, GL | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of IV Acetaminophen Intraoperatively in Obese Patients at Risk for Obstructive Sleep Apnea Undergoing Laparoscopic Cholecystectomy[NCT02056678] | Phase 4 | 0 participants (Actual) | Interventional | 2014-02-28 | Withdrawn (stopped due to Investigator left institution) | ||
| Evaluation of MicroRNA Expression in Blood and Cytology Specimens as a Novel Method for Detecting Barrett's Esophagus[NCT02464930] | 220 participants (Anticipated) | Observational | 2015-04-30 | Recruiting | |||
| A Feasibility Study of Circulating microRNAs as Disease Markers in Pediatric Cancers[NCT01541800] | 20 participants (Anticipated) | Observational | 2010-03-31 | Recruiting | |||
| Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke[NCT04918719] | Phase 2 | 118 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
| A Pilot Trial to Determine the Effective Dose of N-acetylcysteine for Opioid Reduction in Patients Undergoing Spine Surgery.[NCT04562597] | Phase 1/Phase 2 | 50 participants (Actual) | Interventional | 2021-01-20 | Completed | ||
| Liver Injury by Statins in Coronary Heart Disease (CHD) Patients With History of Hepatitis B Virus (HBV) Infection[NCT02808299] | 600 participants (Anticipated) | Observational | 2016-12-31 | Not yet recruiting | |||
| Cells of Monocytic Origin as Surrogate Markers for Individual Drug Effects and Hepatotoxicity[NCT02353455] | 300 participants (Anticipated) | Observational | 2013-03-31 | Recruiting | |||
| A Multi-center, Randomized, Double-blind, Active Control Phase II Study to Investigate Multiple Dosage and Treatments of Magnesium Isoglycyrrhizinate Injection to Cure the Acute Drug-induced Liver Injury[NCT02734966] | Phase 2 | 174 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| Collection of Blood and Stool Samples in Patients With Acute Hepatitis[NCT00001879] | 200 participants | Observational | 1999-03-31 | Completed | |||
| 13C-Methacetin Breath Test for the Prediction of Outcome in in Acute Liver Injury or Acute Liver Failure[NCT02786836] | Phase 2/Phase 3 | 76 participants (Actual) | Interventional | 2016-06-10 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Post operative opioid consumption in the 12 hours that occur post-operatively. (NCT04562597)
Timeframe: 12 hours
| Intervention | IV morphine mg equivalents (Mean) |
|---|---|
| Placebo | 19.4 |
| N-acetylcysteine (NAC) | 15.6 |
Post operative opioid consumption ry 6 hours post operative. Data are reported as mean (95% CI) or mean difference (95% CI) estimated from a linear mixed model of opioid consumption over time including main effects for treatment group, postoperative time, and the interaction between treatment group and postoperative time and a random subject effect. (NCT04562597)
Timeframe: 6-48 hours
| Intervention | IV morphine mg equivalents (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| 6 hours | 18 hours | 24 hours | 30 hours | 36 hours | 42 | 48 | |
| N-acetylcysteine (NAC) | 12.0 | 19.9 | 24.7 | 27.2 | 29.7 | 33.1 | 34.9 |
| Placebo | 14.6 | 25.0 | 29.6 | 34.0 | 37.9 | 40.9 | 43.3 |
The relationship between the cPDR (cumulative PDR of metabolized 13C-Methacetin 20 minutes after ingestion) in single time points of MBT measurements and TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT/transplant free survival at Day 21 | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 1.4 | 0.2 |
Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 (normal carbon dioxide) ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS (transplant free survival) and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: Days 1 and 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Mean Peak PDR for TFS subjects at Day 21 | Mean Peak PDR for non-TFS subjects at Day 21 | |
| 13C-Methacetin Breath Test (MBT) | 10.2 | 1.9 |
This outcome is similar to the peak PDR defined in the primary outcome but as a secondary we are looking at Day 1 or Day 2 peak PDR values. Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT & Day 21 TFS | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 9.1 | 2.3 |
61 reviews available for acetaminophen and Liver Diseases
| Article | Year |
|---|---|
Management of Pharmacologic Adverse Effects in Advanced Liver Disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Liver; Liver Disea | 2022 |
Hepatic failure with fatal outcome during pregnancy following administration of a single therapeutic dose of acetominophen: Case report and literature review.
Topics: Acetaminophen; Antipyretics; Drug Overdose; Fatal Outcome; Female; Humans; Liver Diseases; Liver Fai | 2022 |
Rheumatologic Diseases and the Liver.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthralgia; Biological | 2019 |
A Systematic Review of the Evidence Behind Use of Reduced Doses of Acetaminophen in Chronic Liver Disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Humans; Liver Diseases; Pain | 2018 |
Cyclophilin inhibition as potential therapy for liver diseases.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Cyclophil | 2014 |
[Analgesia in patients with hepatic impairment].
Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; H | 2015 |
New potential biomarkers of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Biomarkers; Blood Proteins; DNA, Mitochondrial; Humans; Liver Diseases; Micr | 2016 |
Modulating GSH synthesis using glutamate cysteine ligase transgenic and gene-targeted mice.
Topics: Acetaminophen; Animals; Antioxidants; Disease Models, Animal; Gene Targeting; Genotype; Glutamate-Cy | 2008 |
Hepatic drug transporters and nuclear receptors: regulation by therapeutic agents.
Topics: Acetaminophen; ATP Binding Cassette Transporter, Subfamily B; Glucocorticoids; Humans; Liver Disease | 2008 |
Adverse reactions associated with acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Anaphylaxis; Antidote | 2009 |
Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Anaphylaxis; Child; Fever; Gastrointestinal Hem | 2009 |
Emergency: acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Charcoal; Chemical and Drug Induced Liver Inju | 2009 |
Hypoxia and hypoxia inducible factors: diverse roles in liver diseases.
Topics: Acetaminophen; Animals; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunity, Innate; Lipid Metabol | 2012 |
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Death; | 2012 |
[Treatment of paracetamol intoxication. Correctly given antidote treatment will prevent liver damage].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2002 |
Liver and kidney diseases.
Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G | 2002 |
[Practical analysis of toxic substances useful for clinical toxicology--4--Acetaminophen].
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Chromatography, High P | 2002 |
Acetaminophen intoxication and length of treatment: how long is long enough?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Chemical a | 2003 |
Role of nitric oxide in liver injury.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Liver; Liver Diseases; N | 2003 |
Acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2003 |
[Clinical application of N-acetylcysteine in liver disease].
Topics: Acetaminophen; Acetylcysteine; Humans; Liver Diseases | 2004 |
An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Chemic | 2005 |
Mechanistic classification of liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Autoimmunity; Calcium; Chemical and Dru | 2005 |
Drug-induced liver disease 2004.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Retroviral Agents; Antitubercular Agents; Chemical and | 2005 |
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Ster | 2006 |
Sinusoidal endothelial cells as an early target for hepatic toxicants.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Advers | 2006 |
[Is there a risk to prescribe paracetamol at therapeutic doses in patients with acute or chronic liver disease?].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chro | 2006 |
Mitochondrial involvement in drug-induced hepatic injury.
Topics: Acetaminophen; Animals; Cell Death; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; | 2006 |
[Alcohol abuse case of severe liver dysfunction induced by acetaminophen poisoning which was diagnosed as non-hepatic toxicity on admission].
Topics: Acetaminophen; Acetylcysteine; Administration, Rectal; Adult; Alcoholism; Analgesics, Non-Narcotic; | 2006 |
Selection of new chemical entities with decreased potential for adverse drug reactions.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Design; Drug-R | 2006 |
The 2006 Bernard B. Brodie Award Lecture. Cyp2e1.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2007 |
Role of Kupffer cells in host defense and liver disease.
Topics: Acetaminophen; Animals; Cell Communication; Fatty Liver; Hemoglobins; Humans; Immune Tolerance; Immu | 2006 |
Drug-induced liver disease in 2006.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Chemical and Drug Induced L | 2007 |
Acetaminophen safety and hepatotoxicity--where do we go from here?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Liver Failur | 2007 |
[Heme oxygenase as a potential therapeutic target for hepatoprotection].
Topics: Acetaminophen; Animals; Biliverdine; Carbon Monoxide; Catalysis; Cells, Cultured; Chemical and Drug | 2007 |
[Abnormality of liver functional test in patients with drug-induced liver injury].
Topics: Acetaminophen; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cardiovas | 2007 |
Hepatotoxicity following the therapeutic use of antipyretic analgesics.
Topics: Acetaminophen; Alcohol Drinking; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug | 1983 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Aged; Alcoholism; Chemical and Drug Induced Liver Injury; Chemical Phenomena; | 1984 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; | 1984 |
Hepatotoxicity: newer aspects of pathogenesis and treatment.
Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages; | 1995 |
Factors and conditions affecting the glucuronidation of oxazepam.
Topics: Acetaminophen; Age Factors; Aged; Aged, 80 and over; Biological Availability; Biotransformation; Die | 1993 |
Paracetamol hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatic Enceph | 1993 |
Classification, etiology, and considerations of outcome in acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepa | 1996 |
Hepatotoxicity of non-narcotic analgesics.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 1998 |
Update in hepatology.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Hepatitis; Hepatitis, Viral, Human; Humans; Liver Cirrhosis | 1999 |
Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Cha | 1999 |
As compared to Paracetamol, does the Paracetamol and Methionine combinations have better efficacy and safety and can it be used safely in the management of pyrexia associated with liver diseases?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Therapy, Combination; Female; Fever; Humans; Liver Dis | 1999 |
Drug-induced liver disease.
Topics: Acetaminophen; Alanine Transaminase; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2000 |
ABC of diseases of liver, pancreas, and biliary system. Other causes of parenchymal liver disease.
Topics: Acetaminophen; Cholangitis, Sclerosing; Cholestasis; Drug Hypersensitivity; Hemochromatosis; Hepatit | 2001 |
Role of macrophages and inflammatory mediators in chemically induced toxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation Mediators; Liver Diseas | 2001 |
Management of paracetamol overdose: current controversies.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chi | 2001 |
Drug metabolism in liver disease.
Topics: Acetaminophen; Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Chronic Disease; H | 1975 |
Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases | 1992 |
Hepatobiliary disease: medical emergencies.
Topics: Acetaminophen; Biliary Tract Diseases; Emergencies; Halothane; Hepatic Encephalopathy; Hepatitis, Vi | 1991 |
Intensive liver care and management of acute hepatic failure.
Topics: Acetaminophen; Critical Care; Hepatic Encephalopathy; Hepatitis B; Hepatitis C; Humans; Liver Diseas | 1991 |
Animal models of fulminant hepatic failure.
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Disease Models, Animal; Galactosamine; Hepat | 1991 |
Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Blood Coagulati | 1986 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
Hepatic effects of acetaminophen. Enhanced toxicity in alcoholics.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Ethanol; Humans; Liver; Liver Dis | 1987 |
[Recent findings on the hepatotoxicity of drugs].
Topics: Acetaminophen; Alcoholism; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytoc | 1985 |
Acute hepatic necrosis and fulminant hepatic failure.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Blood Coagulation Disorders; Brain Dise | 1973 |
11 trials available for acetaminophen and Liver Diseases
| Article | Year |
|---|---|
The hemodynamic effects of intravenous paracetamol (acetaminophen) in patients with chronic liver disease undergoing liver transplantation: a pilot study.
Topics: Acetaminophen; Hemodynamics; Humans; Liver Diseases; Liver Transplantation; Pilot Projects | 2021 |
The effect of 1g of acetaminophen twice daily for 12 weeks on alanine transaminase levels--A randomized placebo-controlled trial.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alanine Transaminase; Double-Blind Method; Drug Administrati | 2015 |
Bioavailability of paracetamol with/without caffeine in Egyptian patients with hepatitis C virus.
Topics: Acetaminophen; Adult; Aged; Analgesics; Arabs; Biological Availability; Caffeine; Female; Hepatitis | 2016 |
Does acetaminophen affect liver function in alcoholic patients?
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Double- | 2003 |
A 20-hour treatment for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Adolescent; Adult; Drug Administ | 2003 |
The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Anaphylaxis; Aspartate Aminotransferases | 2005 |
Reduction of paracetamol metabolism after hepatic resection.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Chromatography, High Pressure Liquid; Drug Administra | 2006 |
Clinical safety of high oral doses of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases | 1983 |
Assay of paracetamol and its metabolites in urine, plasma and saliva of children with chronic liver disease.
Topics: Acetaminophen; Adult; Child; Child, Preschool; Chromatography, High Pressure Liquid; Chronic Disease | 1995 |
Metabolism of paracetamol in children with chronic liver disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biotransformation; Child; Child, Preschool; Chromatography, | 1996 |
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Drug Overd | 1991 |
390 other studies available for acetaminophen and Liver Diseases
| Article | Year |
|---|---|
Fifteen-minute update: International normalised ratio as the treatment end point in children with acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Child; Humans; International Normalized Ratio; Liver Diseases; Vitami | 2023 |
The difference of chows affects mouse physiological conditions.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Li | 2022 |
A jojoba (Simmondsia chinensis) seed cake extracts express hepatoprotective activity against paracetamol-induced toxicity in rats.
Topics: Acetaminophen; Animals; Antioxidants; bcl-2-Associated X Protein; Chemical and Drug Induced Liver In | 2022 |
Tandem mass tag-based proteomics analysis reveals the effects of Guri Gumu-13 pill on drug-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Medicine, Chi | 2022 |
Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury.
Topics: Acetaminophen; Animals; Arachidonate 5-Lipoxygenase; Bile Acids and Salts; Chemical and Drug Induced | 2023 |
Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrac | 2022 |
Therapeutic effect of 6-shogaol on acetaminophen-induced hepatotoxicity in mice: an experimental study.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Cation Transport Proteins; Chemical and Drug Induced Liver Injury; Cyclins; | 2022 |
Hepatoprotective Effects of Radish (
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2022 |
Hepatoprotective Effects of Radish (
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2022 |
Hepatoprotective Effects of Radish (
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2022 |
Hepatoprotective Effects of Radish (
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2022 |
Natural Product 2-Oxokolavenol Is a Novel FXR Agonist.
Topics: Acetaminophen; Humans; Liver; Liver Diseases; Receptors, Cytoplasmic and Nuclear | 2022 |
Celastrol-loaded biomimetic nanodrug ameliorates APAP-induced liver injury through modulating macrophage polarization.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Biomimetics; Chemical and Drug Induced Liver Injur | 2023 |
Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Leukocyte Elastase; Liver Diseases; | 2023 |
A novel variant of the
Topics: Acetamides; Acetaminophen; Administration, Oral; Adult; Age Factors; Breath Tests; Carbon Dioxide; C | 2020 |
PiTMaP: A New Analytical Platform for High-Throughput Direct Metabolome Analysis by Probe Electrospray Ionization/Tandem Mass Spectrometry Using an R Software-Based Data Pipeline.
Topics: Acetaminophen; Animals; Brain; Chemical and Drug Induced Liver Injury; Discriminant Analysis; High-T | 2020 |
Abnormal liver function tests predict transfer to intensive care unit and death in COVID-19.
Topics: Acetaminophen; Antibodies, Monoclonal, Humanized; Antipyretics; Antiviral Agents; COVID-19; Critical | 2020 |
Tragic consequences of paracetamol therapy in chronic liver disease
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Liver; Liver Diseases | 2020 |
Deranged liver function in pregnancy.
Topics: Acetaminophen; Adult; Aftercare; Analgesics, Non-Narcotic; Antiemetics; Diagnosis, Differential; Fem | 2021 |
AST/ALT levels, MDA, and liver histopathology of
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; | 2021 |
Acute Liver Failure Triggered by Therapeutic Dose of Acetaminophen in a Patient with Cystic Fibrosis.
Topics: Acetaminophen; Cystic Fibrosis; Humans; Liver Cirrhosis; Liver Diseases; Liver Failure, Acute; Lung; | 2023 |
Accuracy of the paracetamol-aminotransferase product to predict hepatotoxicity in paracetamol overdose treated with a 2-bag acetylcysteine regimen.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose | 2018 |
Thymoquinone and curcumin modify inducible nitric oxide synthase, caspase 3, and thioredoxin immunohistochemical expression in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzoquinones; Bilirubin; | 2019 |
Constitutive release of CPS1 in bile and its role as a protective cytokine during acute liver injury.
Topics: Acetaminophen; Acute Lung Injury; Adult; Animals; Bile; Bile Acids and Salts; Carbamoyl-Phosphate Sy | 2019 |
[Acute renal failure in a healthy 19-year-old woman after intake of 7 g of paracetamol].
Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Drug Overdose; Female; Hospitalization | 2019 |
Hepatoprotective effect of essential oils of
Topics: Acetaminophen; Animals; Female; Liver; Liver Diseases; Male; Mice; Nepeta; Oils, Volatile; Protectiv | 2019 |
Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development.
Topics: Acetaminophen; Animals; Ethanol; Gene Expression Regulation, Developmental; Gene Knockdown Technique | 2013 |
Emerging efforts for discovering new biomarkers of liver disease and hepatotoxicity.
Topics: Acetaminophen; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Metabolom | 2014 |
NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Betaine; Blotting, Western; Cells, Cultured; Cyste | 2015 |
Schisandra sphenanthera Extract Facilitates Liver Regeneration after Partial Hepatectomy in Mice.
Topics: Acetaminophen; Animals; Cell Proliferation; Drugs, Chinese Herbal; Hepatectomy; Hepatocytes; Liver; | 2016 |
Incidence and characterization of acute kidney injury after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Biomarkers; Cre | 2016 |
Caffeic acid attenuated acetaminophen-induced hepatotoxicity by inhibiting ERK1/2-mediated early growth response-1 transcriptional activation.
Topics: Acetaminophen; Animals; Caffeic Acids; Cell Nucleus; Early Growth Response Protein 1; Extracellular | 2016 |
Case 2-2017. An 18-Year-Old Woman with Acute Liver Failure.
Topics: Abdomen; Acetaminophen; Adolescent; Diagnosis, Differential; Female; Hepatolenticular Degeneration; | 2017 |
Polyphenols rich Passiflora leschenaultii leaves modulating Farnesoid X Receptor and Pregnane X Receptor against paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Antioxidants; Biomarkers; Body Weight; Liver Diseases; Male; Molecular Docki | 2017 |
Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Culture Techniques; Chemical and D | 2008 |
Innate immunity and acetaminophen-induced liver injury: why so many controversies?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; | 2008 |
Antioxidant and hepatoprotective activity of aqueous extract of Solanum fastigiatum (false "Jurubeba") against paracetamol-induced liver damage in mice.
Topics: Acetaminophen; Animals; Antioxidants; Brazil; Chemical and Drug Induced Liver Injury; Dose-Response | 2008 |
Protective effect of a fermented substance from Saccharomyces cerevisiae on liver injury in mice caused by acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2008 |
Hepatoprotective effect of Hibiscus hispidissimus Griffith, ethanolic extract in paracetamol and CCl4 induced hepatotoxicity in Wistar rats.
Topics: Acetaminophen; Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver In | 2008 |
Renal injury at first presentation as a predictor for poor outcome in severe paracetamol poisoning referred to a liver transplant unit.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cohort Studies; Creatinine; Databases, Factual; Fema | 2009 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Hum | 2008 |
Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Chemical and Drug Induced Liver I | 2009 |
Chronic intermittent hypoxia and acetaminophen induce synergistic liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; As | 2009 |
Obstructive sleep apnoea and acetaminophen safety - is the liver at risk?
Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and | 2009 |
Effect of Clausena dentata (Willd.) M. Roem. against paracetamol induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Circulating microRNAs, potential biomarkers for drug-induced liver injury.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Rela | 2009 |
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; C | 2009 |
Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury.
Topics: Acetaminophen; Adrenergic Agonists; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensi | 2009 |
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; | 2009 |
Paracetamol poisoning below toxic level causing liver damage in a fasting adult.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dru | 2009 |
[Paracetamol use in patients with liver disease].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Liver Disea | 2009 |
Hepatoprotective effects of an anthocyanin fraction from purple-fleshed sweet potato against acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Alanine Transaminase; Aniline Compounds; Animals; Anthocyanins; Aspartate Aminotransf | 2009 |
Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Aspar | 2009 |
Limiting paracetamol pack size: has it worked in the UK?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Canada; Commerce; Dose-Response Relationship, Drug; Drug Ov | 2009 |
Intestinal glucose uptake protects liver from lipopolysaccharide and D-galactosamine, acetaminophen, and alpha-amanitin in mice.
Topics: Acetaminophen; Administration, Oral; Alpha-Amanitin; Animals; Chemical and Drug Induced Liver Injury | 2009 |
Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Biomarkers; Catalase; Curcumin; Drug Synergism; Glutathione | 2010 |
Liver damage from chronic acetaminophen dosing is dangerous, but not the only risk.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Autistic Disorder; Chemical and Drug Induced Liver I | 2009 |
Hepatoprotective effects of ethanolic extract of Cnidoscolus aconitifolius on paracetamol-induced hepatic damage in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Ethanol; Euphorbiaceae; Liver; Liver Diseases; Mal | 2010 |
Resveratrol and liver disease: from bench to bedside and community.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carbon Tetrachloride; Cytokine | 2010 |
Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug In | 2010 |
17β-Estradiol protects against acetaminophen-overdose-induced acute oxidative hepatic damage and increases the survival rate in mice.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Animals; Dose-Response Relationship, Drug; Estra | 2011 |
Protective effect of Woodfordia fruticosa flowers against acetaminophen-induced hepatic toxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2011 |
A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Chemical and Drug Induced Liver Inj | 2011 |
Liver tumours, toxic hepatitis, intestinal failure-associated liver disease in children.
Topics: Acetaminophen; Amoxicillin-Potassium Clavulanate Combination; Analgesics, Non-Narcotic; Anti-Bacteri | 2012 |
Moringa oleifera hydroethanolic extracts effectively alleviate acetaminophen-induced hepatotoxicity in experimental rats through their antioxidant nature.
Topics: Acetaminophen; Aldehydes; Animals; Antioxidants; Biomarkers; Biphenyl Compounds; Ethanol; Flowers; F | 2012 |
Diurnal variation of hepatic antioxidant gene expression in mice.
Topics: Acetaminophen; Aging; Animals; Antioxidants; Circadian Rhythm; CLOCK Proteins; Female; Gene Expressi | 2012 |
Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Central Nervous System Depressants; | 2002 |
A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Acute Disease; Animals; Apoptosis; Cell Adhesion Molecules; Chemical and Drug Induced | 2002 |
Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced | 2002 |
Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Connective Tissue Growth Factor; Gen | 2002 |
Rapid spectrophotometric method for serum glutathione S-transferases activity.
Topics: Acetaminophen; Adolescent; Adult; Aged; Child; Child, Preschool; Dinitrochlorobenzene; Enzyme Inhibi | 2002 |
Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Clodronic Acid | 2002 |
Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2002 |
The formation of oxidative stress condition in the experimental chemically induced hepatotoxicity.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2002 |
The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Blotting, Western; Chelating Agents; Chemical and Drug Induced Liver Injury; | 2003 |
Paracetamol hepatotoxicity at therapeutic doses.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cytochrome P | 2003 |
[Paracetamol overdose and experimental cholestasis induced gene expression regulation that codified P-Glycoprotein type 1 in rats].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; ATP Binding Cassette Transporter, S | 2002 |
Regular medication and paracetamol overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Data Collection; Dr | 2003 |
Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytoprotection; Gene Expression; Hea | 2003 |
Glycosmis arborea extract as a hepatoprotective agent.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Body Weight; Carbon Tetrachlorid | 2003 |
Effect of Azadirachta indica on paracetamol-induced hepatic damage in albino rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Aza | 2003 |
Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Chemi | 2003 |
A population-based cohort study of mortality among adults prescribed paracetamol in Denmark.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Cardiovascular Diseases; Cause of Death; Cerebrovascu | 2003 |
Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.
Topics: Acetaminophen; Animals; Cell Division; Chemical and Drug Induced Liver Injury; Colchicine; Cytochrom | 2003 |
Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity.
Topics: Acetaminophen; Acetylcysteine; alpha-Tocopherol; Analgesics, Non-Narcotic; Animals; Antioxidants; Bl | 2003 |
Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants.
Topics: Acetaminophen; Animals; Blotting, Western; Calpain; Carbon Tetrachloride; Carrier Proteins; Chemical | 2003 |
Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspart | 2003 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver | 2003 |
Decreased glutathione in patients with anorexia nervosa. Risk factor for toxic liver injury?
Topics: Acetaminophen; Adolescent; Adult; Amino Acids; Anorexia Nervosa; Body Mass Index; Female; Glutathion | 2004 |
Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in mice.
Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Bromobenzenes; Caspase 3; | 2004 |
Assessment of the protective potential of Premna tomentosa (L. Verbenaceae) extract on lipid profile and lipid-metabolizing enzymes in acetaminophen-intoxicated rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Li | 2004 |
Hepatoprotective effect of Himoliv, a polyherbal formulation in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Car | 2003 |
Preventive effect of Thea sinensis melanin against acetaminophen-induced hepatic injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Camellia sinensis; Chemical and Drug Induced Liver Inj | 2004 |
Evaluation of the protective efficacy of Asteracantha longifolia on acetaminophen-induced liver damage in rats.
Topics: Acanthaceae; Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotran | 2004 |
Intravenous administration of N-acetylcysteine: interference with coagulopathy testing.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Child; Female; Humans; | 2004 |
Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Acute-Phase Proteins; Adenoviridae; Animals; Carrier Proteins; Chemical and Drug Indu | 2005 |
Alpha-fetoprotein is a predictor of outcome in acetaminophen-induced liver injury.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; alpha-Fetoproteins; | 2005 |
Hepatoprotective effects of the water extract from adzuki bean hulls on acetaminophen-induced damage in rat liver.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injur | 2004 |
Acetaminophen toxicity revisited: is drug-induced hepatotoxity immune mediated?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Humans; Ki | 2005 |
Oral or intravenous N-acetylcysteine for acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Chemical and Drug Induced Liver Injury; Humans; | 2005 |
Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Fe | 2005 |
Effect of ribose cysteine pretreatment on hepatic and renal acetaminophen metabolite formation and glutathione depletion.
Topics: Acetaminophen; Animals; Blood Urea Nitrogen; Buthionine Sulfoximine; Chemical and Drug Induced Liver | 2005 |
Proteomic identification of potential susceptibility factors in drug-induced liver disease.
Topics: Acetaminophen; Affinity Labels; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Aff | 2005 |
Platelet-activating factor (PAF) involvement in acetaminophen-induced liver toxicity and regeneration.
Topics: Acetaminophen; Acetyltransferases; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug I | 2005 |
Protective effect of Premna tomentosa extract (L. verbanacae) on acetaminophen-induced mitochondrial dysfunction in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Lamiaceae; Liver Diseases; Male; Mit | 2005 |
Protection against paracetamol-induced hepatic injury by prazosin pre-treatment in CD-1 mice.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alanine Transaminase; Analge | 2005 |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2005 |
A new acetaminophen nomogram with a different purpose.
Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced | 2005 |
A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Alcohol Drinking; Analgesics, Non-N | 2005 |
Effect of Cistus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2006 |
Role of caspases in acetaminophen-induced liver injury.
Topics: Acetaminophen; Amino Acid Chloromethyl Ketones; Analgesics, Non-Narcotic; Animals; Caspase Inhibitor | 2006 |
Protective effect of crude extract from Wedelia paludosa (Asteraceae) on the hepatotoxicity induced by paracetamol in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2006 |
Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice.
Topics: Acetaminophen; Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Deoxyribonuc | 2006 |
Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Genetic | 2006 |
Hepatoprotective studies on Hedyotis corymbosa (L.) Lam.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Paracetamol induced hepatotoxicity.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Bilirubin; Blood Glucose; Chemical and Drug Ind | 2006 |
Endothelially derived nitric oxide affects the severity of early acetaminophen-induced hepatic injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Disease Models | 2006 |
Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Fluorescen | 2006 |
Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Female; Gene Expression Regulation, Enzy | 2006 |
The pharmacokinetics of a single rectal dose of paracetamol (40 mg x kg(-1)) in children with liver disease.
Topics: Acetaminophen; Administration, Rectal; Adolescent; Analgesics, Non-Narcotic; Anesthesia, General; Bi | 2006 |
Hepatoprotective activity of Psidium guajava Linn. leaf extract.
Topics: Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2006 |
Blockade of the receptor for advanced glycation end products attenuates acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glycation End Products, Advanced; In | 2006 |
The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Catalase; CD13 Antigens; Glutathione | 2006 |
Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Boswellia; Carbon Tetrachloride; Chemical and Drug | 2006 |
Osteoarthritis of the knee.
Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Humans; Liver Diseases; Osteoarthritis, Knee | 2006 |
Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Acids, M | 2006 |
Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response | 2006 |
Comment on "endothelially derived nitric oxide affects the severity of early acetaminophen-induced hepatic injury in mice".
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Liver Diseas | 2006 |
Acute liver failure in children: they really are not just small adults.
Topics: Acetaminophen; Adolescent; Autoimmune Diseases; Child; Child, Preschool; Hepatic Encephalopathy; Hum | 2006 |
Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Biomarkers; Catalase; Chemical and Drug | 2007 |
Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotra | 2006 |
Acetaminophen induces ER dependent signaling in mouse liver.
Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Ove | 2007 |
Hepatoprotective effects of Chai-Hu-Ching-Kan-Tang on acetaminophen-induced acute liver injury in rats.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2007 |
Safety of recommended doses of paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Huma | 2007 |
Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biopsy; Cytochrome P-450 Enzyme System; Dose-Respo | 2007 |
Role of nitric oxide and reduced glutathione in the protective effects of aminoguanidine, gadolinium chloride and oleanolic acid against acetaminophen-induced hepatic and renal damage.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Nar | 2007 |
Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; | 2007 |
VEGF isoforms and receptors expression throughout acute acetaminophen-induced liver injury and regeneration.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Ge | 2007 |
Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate.
Topics: Acetaminophen; Acyl-CoA Oxidase; Amidohydrolases; Animals; Anticholesteremic Agents; Cell Adhesion M | 2007 |
Protective role of Raphanus sativus root extract on paracetamol-induced hepatotoxicity in albino rats.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2007 |
Impact of activated charcoal after acute acetaminophen overdoses treated with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Indu | 2007 |
Comparison of rocket and crossed immuno-electrophoresis assays for determination of the level of actin complexing of Gc globulin.
Topics: Acetaminophen; Actins; Calibration; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorb | 2007 |
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; bcl-2-Associated X Protein; Chemical and Drug Indu | 2008 |
Efficacy of Raphanus sativus in the treatment of paracetamol-induced hepatotoxicity in albino rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Catalase; Chemical and Drug Induced Liver Injury; | 2007 |
Platelet activating factor (PAF) antagonism with ginkgolide B protects the liver against acute injury. importance of controlling the receptor of PAF.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2008 |
Acetaminophen usage patterns and concentrations of glutathione and gamma-glutamyl transferase in alcoholic subjects.
Topics: Acetaminophen; Adult; Alcohol Drinking; Alcoholism; Analgesics, Non-Narcotic; Biomarkers, Pharmacolo | 2007 |
[Acetaminophen: hepatotoxicity at therapeutic doses and risk factors].
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; D | 2007 |
Acetaminophen-induced liver damage in mice: effects of some medicinal plants on the oxidative defense system.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2008 |
The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidan | 2008 |
alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Catec | 2008 |
Effect of sesame oil against acetaminophen-induced acute oxidative hepatic damage in rats.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Animals; Chemical and | 2008 |
Use of over-the-counter analgesics in patients with chronic liver disease: physicians' recommendations.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2008 |
AASLD public policy statement should be evidence-based.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Evidence-Based Medicine; Gastroenterology; Humans; Liver Di | 2008 |
A 2-year-old boy with fever and altered mental status.
Topics: Acetaminophen; Child, Preschool; Contraindications; Diagnosis, Differential; Fever; Humans; Intensiv | 2008 |
Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and | 2008 |
Propolis reverses acetaminophen induced acute hepatorenal alterations: a biochemical and histopathological approach.
Topics: Acetaminophen; Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Antioxida | 2008 |
Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 2008 |
Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholism; Child; Child, Preschool; Drug | 2008 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Ulcer, back pain, and jaundice in an alcoholic.
Topics: Acetaminophen; Adult; Alcoholism; Back Pain; Chemical and Drug Induced Liver Injury; Dextropropoxyph | 1983 |
Role of microsomal drug detoxifying enzyme systems in paracetamol induced liver injury in rats.
Topics: Acetaminophen; Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Glucose-6-Phosphat | 1983 |
Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters.
Topics: Acetaminophen; Alanine Transaminase; Animals; Blood Proteins; Chemical and Drug Induced Liver Injury | 1983 |
Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice.
Topics: Acetaminophen; Animals; Anisoles; Butylated Hydroxyanisole; Chemical and Drug Induced Liver Injury; | 1984 |
Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice.
Topics: Acetaminophen; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Erythrocytes; Liver; | 1983 |
[The significance of lipid peroxidation in drug-induced liver damage].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Humans; Lipid Peroxides | 1984 |
Problems in the necropsy diagnosis of alcoholic liver disease.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; D | 1984 |
Factors contributing to mortality in paracetamol-induced hepatic failure.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Critical Care; Female; Hepatic Encepha | 1981 |
Platelet adhesiveness to glass beads in liver disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chronic Disease; Glass; Hemoperfusion; Hepati | 1982 |
Evaluation of an enzymic procedure for the measurement of acetaminophen.
Topics: Acetaminophen; Amidohydrolases; Aminophenols; Chromatography, High Pressure Liquid; Colorimetry; Eme | 1983 |
Severe hepatic damage after acetaminophen use in psittacosis.
Topics: Acetaminophen; Humans; Liver; Liver Diseases; Male; Middle Aged; Necrosis; Psittacosis | 1983 |
Late presentation of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Middle | 1982 |
Paracetamol self-poisoning: diagnosis, management, and outcome.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Australia; Chemical and Drug | 1982 |
Anti-LSP antibodies in acute liver disease.
Topics: Acetaminophen; Acute Disease; Autoantibodies; Chemical and Drug Induced Liver Injury; Hepatitis, Alc | 1982 |
Cimetidine and acetylcysteine as antidote for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Cimetidine; Cytoch | 1982 |
Bacteraemia in patients with fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; H | 1982 |
Disturbances of lactate metabolism in patients with liver damage due to paracetamol overdose.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatitis, Viral, Human; Human | 1981 |
Liver failure in an infant.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Humans; Infa | 1980 |
Cimetidine protects against acetaminophen hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Chemical and | 1981 |
Raised serum biliverdin in hepatic necrosis.
Topics: Acetaminophen; Animals; Bile Acids and Salts; Bilirubin; Biliverdine; Chemical and Drug Induced Live | 1981 |
Cimetidine protects against acetaminophen hepatoxicity.
Topics: Acetaminophen; Adolescent; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Female; Guan | 1981 |
Massive cerebral edema associated with fulminant hepatic failure in acetaminophen overdose: possible role of cranial decompression.
Topics: Acetaminophen; Adolescent; Brain Edema; Chemical and Drug Induced Liver Injury; Female; Humans; Live | 1981 |
Overview of alkylation and peroxidation mechanisms in acute lethal hepatocellular injury by chemically reactive metabolites.
Topics: Acetaminophen; Alkylation; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chem | 1981 |
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Injections, Intraveno | 1980 |
Predicting outcome of paracetamol poisoning by use 14C-aminopyrine breath test.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aminopyrine; Breath Tests; Carbon Radioisotopes; Chemical an | 1980 |
Acetaminophen-induced microvascular injury in the rat liver: protection with misoprostol.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Kinetics; Liver; Liver Diseases; Mal | 1995 |
A protective effect of glutathione-dextran macromolecular conjugates on acetaminophen-induced hepatotoxicity dependent on molecular size.
Topics: Acetaminophen; Animals; Antimetabolites; Aspartate Aminotransferases; Buthionine Sulfoximine; Chemic | 1994 |
Evaluation of the protective potential of Artemisia maritima extract on acetaminophen- and CCl4-induced liver damage.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Liv | 1995 |
Effect of Teucrium stocksianum on paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Li | 1995 |
Preventive and curative effects of Artemisia absinthium on acetaminophen and CCl4-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Che | 1995 |
Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice.
Topics: Acetaminophen; Animals; Cadmium Poisoning; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 1995 |
Acetaminophen-induced hepatic injury in mice: the role of lipid peroxidation and effects of pretreatment with coenzyme Q10 and alpha-tocopherol.
Topics: Acetaminophen; Alanine Transaminase; Animals; Coenzymes; Glutathione; Lipid Peroxidation; Liver; Liv | 1995 |
[Protective effect of the fulvotomentosides on paracetamol-induced hepatotoxicity in mice].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Glutathione; | 1995 |
Effect of polysaccharide peptide (PSP) on glutathione and protection against paracetamol-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Adjuvants, Immunologic; Animals; Chemical and Drug Induced Liver Injury; Glutathione; | 1994 |
The evaluation of hepatoprotective effects of Taiwan folk medicine 'teng-khia-u'.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Division; Chemical a | 1995 |
Cimetidine as adjunctive treatment for acetaminophen overdose.
Topics: Acetaminophen; Adult; Cimetidine; Drug Overdose; Female; Humans; Liver Diseases; Male | 1995 |
The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction.
Topics: Acetaminophen; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Human | 1995 |
[Does hyperthyroidism promote drug hepatotoxicity].
Topics: Acetaminophen; Adolescent; Aged; Estrogens; Female; Genital Diseases, Female; Headache; Humans; Hype | 1994 |
An experimental study on the disturbance of liver circulation and the change of hemorrheology in dogs with acute liver damage.
Topics: Acetaminophen; Animals; Blood Viscosity; Chemical and Drug Induced Liver Injury; Dogs; Female; Hemor | 1994 |
Effect of ursodeoxycholic acid on in vivo and in vitro toxic liver injury in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Car | 1994 |
Acetaminophen ingestion in childhood--cost and relative risk of alternative referral strategies.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child, Preschool; Cost-Benefit Analysis; Drug | 1994 |
The effect of Chinese hepatoprotective medicines on experimental liver injury in mice.
Topics: 1-Propanol; Acetaminophen; Animals; Cadmium; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 1994 |
Baseline liver function tests following acetaminophen ingestion. What is the utility?
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Li | 1994 |
Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury.
Topics: Acetaminophen; Biopsy; Cell Count; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hu | 1994 |
Effect of hepatotoxic doses of paracetamol and carbon tetrachloride on the serum and hepatic carboxylesterase activity in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Carboxylic Es | 1993 |
Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury | 1994 |
Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1993 |
Effect of thiola on acetaminophen induced hepatic necrosis in mice.
Topics: Acetaminophen; Animals; Behavior, Animal; Chemical and Drug Induced Liver Injury; Drug Interactions; | 1993 |
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflav | 1993 |
Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Biliary Tract; Chemical and Drug Induced Liver Injury; Dose-Response Relatio | 1993 |
Role of lipid peroxidation in acetaminophen-induced hepatotoxicity: comparison with carbon tetrachloride.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Interacti | 1993 |
Development of an in vitro hepatotoxicity assay for assessing the effects of chronic drug exposure.
Topics: Acetaminophen; Amitriptyline; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; Hu | 1993 |
Plasma-kallikrein clearance by the liver of acetaminophen-intoxicated rats.
Topics: Acetaminophen; Animals; Biological Transport; Fasting; Kallikreins; Liver; Liver Diseases; Male; Met | 1993 |
Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury.
Topics: 1-Propanol; Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug In | 1993 |
[Plasma levels of alanine aminotransferase in experimental liver necrosis induced by overdosage of paracetamol in mice].
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Female; Liver; | 1995 |
Cholestasis as a liver protective factor in paracetamol acute overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cholestasi | 1995 |
Effects of phenobarbital on aniline metabolism in primary liver cell culture of rats with ethionine-induced liver disorder.
Topics: Acetaminophen; Aminophenols; Aniline Compounds; Animals; Cells, Cultured; Chemical and Drug Induced | 1996 |
Sex- and age-dependent acetaminophen hepato- and nephrotoxicity in Sprague-Dawley rats: role of tissue accumulation, nonprotein sulfhydryl depletion, and covalent binding.
Topics: Acetaminophen; Age Factors; Animals; Chemical and Drug Induced Liver Injury; Female; Kidney; Kidney | 1996 |
Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bile Acids and Salts; Chemical and Dru | 1996 |
Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; India; Li | 1995 |
Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity.
Topics: Acetaminophen; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Dru | 1996 |
Factors responsible for continuing morbidity after paracetamol poisoning in Chinese patients in Hong Kong.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Asian People; C | 1996 |
Increased resistance to acetaminophen-induced hepatotoxicity in retrovirus-infected mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver | 1996 |
Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Ch | 1997 |
Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical a | 1996 |
Survival, proliferation, and functions of porcine hepatocytes encapsulated in coated alginate beads: a step toward a reliable bioartificial liver.
Topics: Acetaminophen; Alginates; Animals; Biotransformation; Capsules; Cell Division; Cell Survival; Cells, | 1997 |
Effects of phenethyl isothiocyanate on acetaminophen metabolism and hepatotoxicity in mice.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Cytochrome P-450 CYP2E1 Inhibito | 1997 |
Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic; | 1997 |
Should methionine be added to every paracetamol tablet?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Res | 1997 |
Effects of fructose-induced hypertriglyceridemia on hepatorenal toxicity of acetaminophen in rats: role of pharmacokinetics and metabolism of acetaminophen.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dose | 1997 |
Acetaminophen toxicity in an urban county hospital.
Topics: Accidents; Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholism; Chemical and Drug | 1997 |
2-Methyl-thiazolidine-2,4-dicarboxylic acid as prodrug of L-cysteine. Protection against paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Liver | 1997 |
Paracetamol hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Liver Disea | 1997 |
Acetaminophen toxicity in an urban county hospital.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Dise | 1998 |
Acetaminophen toxicity in an urban county hospital.
Topics: Acetaminophen; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug | 1998 |
Esculetin prevents liver damage induced by paracetamol and CCL4.
Topics: Acetaminophen; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1998 |
Emergency! Acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anorexia Nervosa; Chemical and Drug Induced Liv | 1998 |
Role of cimetidine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Overdose; Humans; L | 1998 |
Protective effect of the mold Monascus anka against acetaminophen-induced liver toxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aniline Hydroxylase; Animals; Ascomycota; Aspartate Aminotr | 1998 |
Mechanisms of protection by S-allylmercaptocysteine against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Coenzymes; Cys | 1998 |
Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 1998 |
Late-presenting acute acetaminophen toxicity and the role of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical a | 1998 |
Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; Cell Division; Chemical and Drug Induced Li | 1999 |
Effect of orally administered reduced- and oxidized-glutathione against acetaminophen-induced liver injury in rats.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Che | 1998 |
"The silent killer": chronic acetaminophen toxicity in a toddler.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Fatal Outcome; Humans; Infant; Infant, New | 1999 |
Antihepatotoxic activity of Swertia chirata on paracetamol and galactosamine induced hepatotoxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 1999 |
Effects of Corylus avellana in acetaminophen and CCl4 induced toxicosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Li | 1999 |
Ameliorative effect of an urinary preparation on acetaminophen and D-galactosamine induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Humans; | 1999 |
[Benzodiazepines metabolism in various models of experimental liver diseases].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Benzodiazepines; Chemical and Drug | 1999 |
Nicotinamide and methionine reduce the liver toxic effect of methotrexate.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Aspart | 1999 |
Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxication in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Beh | 1999 |
Transformation of an acetaminophen toxicity nomogram to an artificial neural network.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Computer Simulation; Gastroin | 1999 |
Protective effect of ethanol against acetaminophen-induced hepatotoxicity in mice: role of NADH:quinone reductase.
Topics: Acetaminophen; Alcohol Dehydrogenase; Aminopyrine N-Demethylase; Analgesics, Non-Narcotic; Animals; | 1999 |
Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug I | 2000 |
Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2.
Topics: Acetaminophen; Animals; Antibodies; Apoptosis; Chemical and Drug Induced Liver Injury; Chemokine CCL | 2000 |
Paracetamol hepatotoxicity and alcohol consumption in deliberate and accidental overdose.
Topics: Acetaminophen; Adolescent; Adult; Aged; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Dru | 2000 |
Reduction in incidence of severe paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2000 |
Endotoxin pretreatment protects against the hepatotoxicity of acetaminophen and carbon tetrachloride: role of cytochrome P450 suppression.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemic | 2000 |
Protective effect of leaf extract of Ficus hispida Linn. against paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2000 |
Yang-Gan-Wan protects mice against experimental liver damage.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2000 |
Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Antioxidants; Asteraceae; Carbon Tetrachloride; Chemical and Drug Induced Li | 2000 |
Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Biotransformation; Chemical and Dru | 2000 |
Hepatotoxicity of acetaminophen and N-acetyl-p-benzoquinone imine and enhancement by fructose.
Topics: Acetaminophen; Alanine Transaminase; Allopurinol; Animals; Benzoquinones; Chemical and Drug Induced | 2000 |
Acetaminophen causes an increased International Normalized Ratio by reducing functional factor VII.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anticoagulants; Blood Coagulation; | 2000 |
Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)-carboxylic acid in mice.
Topics: Acetaminophen; Aldehydes; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; | 2001 |
Antioxidant and hepatoprotective effects of punicalagin and punicalin on acetaminophen-induced liver damage in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2001 |
Role of taurine in preventing acetaminophen-induced hepatic injury in the rat.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Apopto | 2001 |
Evaluation of hepatoprotective activity of legumes.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2001 |
Hepatoprotective activity of Cassia fistula leaf extract.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2001 |
Temporal profile of total, bound, and free Gc-globulin after acetaminophen overdose.
Topics: Acetaminophen; Actins; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug | 2001 |
[Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver].
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspartate Am | 2001 |
Use of acetaminophen in the treatment of osteoarthritis in patients with liver disease: comment on the 2000 update of the American College of Rheumatology recommendations for management of hip and knee osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Liver Diseases; Osteoarthritis, Hip; Osteoarthritis | 2001 |
Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Campanulaceae; Chemical a | 2001 |
Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Drug Resistance; Inflamma | 2002 |
Acetaminophen hepatotoxicity: the first 35 years.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Anticonvulsants; Aspa | 2002 |
Concomitant overdosing of other drugs in patients with paracetamol poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Dr | 2002 |
Acetaminophen poisoning in children: treat early and long enough.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver | 2002 |
Predictors of outcome after acetaminophen poisoning in children and adolescents.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Arkansas; | 2002 |
Paracetamol metabolism following overdosage: application of high performance liquid chromatography.
Topics: Acetaminophen; Adult; Biotransformation; Chemical and Drug Induced Liver Injury; Chromatography, Hig | 1977 |
Letter: cysteamine treatment in paracetamol overdose.
Topics: Acetaminophen; Adult; Alcohol Drinking; Aspartate Aminotransferases; Chemical and Drug Induced Liver | 1975 |
Letter: Breathing control in liver disease.
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Diseases; L | 1976 |
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; | 1976 |
Serum alpha-fetoprotein levels in patients with acute and chronic liver disease. Relation to hepatocellular regeneration and development of primary liver cell carcinoma.
Topics: Acetaminophen; Acute Disease; Adult; alpha-Fetoproteins; Carcinoma, Hepatocellular; Chronic Disease; | 1977 |
Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Cysteamine; Electron Tra | 1978 |
Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Amanita; Autopsy; Brain Edema; Drug Hypersensit | 1975 |
Prevention of paracetamol-induced liver damage in mice with glutathione.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Gl | 1975 |
Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen.
Topics: Acetaminophen; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical and Drug Induced Li | 1977 |
Comparison of in vivo and in vitro drug metabolism in experimental hepatic injury in the rat.
Topics: Acetaminophen; Aminopyrine; Aminopyrine N-Demethylase; Animals; Breath Tests; Carbon Dioxide; Carbon | 1979 |
Acetaminophen overdose: a growing health care hazard.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Ga | 1979 |
Paracetamol metabolism in chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Chronic Disease; Female; Half-Life; Humans; Liver Diseases; Male; Middle | 1979 |
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cyst | 1979 |
Late treatment of paracetamol poisoning with mercaptamine.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; | 1978 |
The chief scientist reports ... prevention of hepatic necrosis following paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cyst | 1978 |
Evaluation of paracetamol-induced damage in liver biopsies. Acute changes and follow-up findings.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Dose-Response Relationship | 1976 |
Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans | 1977 |
Acetaminophen toxity.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Li | 1977 |
Antipyrine, paracetamol, and lignocaine elimination in chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Antipyrine; Chronic Disease; Female; Half-Life; Humans; Kinetics; Lidoca | 1977 |
Early prediction of the outcome of a paracetamol overdose based on an analysis of 163 patients.
Topics: Acetaminophen; Bilirubin; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver Diseases | 1977 |
The clinical significance of increased plasma levels of liver-synthesized coagulation factors in liver disease.
Topics: Acetaminophen; Acute Disease; Biliary Tract Diseases; Blood Coagulation Factors; Chemical and Drug I | 1977 |
Treatment of acute paracetamol poisoning.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver Diseases | 1977 |
In vitro spectral alteration of hepatic cytochrome P-450 by experimental drug injury.
Topics: Acetaminophen; Animals; Buffers; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Cytoc | 1977 |
Paracetamol overdose in man: relationship between pattern of urinary metabolites and severity of liver damage.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cysteine; Female; Glucuronate | 1976 |
Fatal massive hepatic necrosis following acetaminophen overdose.
Topics: Acetaminophen; Adult; Autopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney; Kidne | 1976 |
The role of biotransformation in chemical-induced liver injury.
Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cr | 1976 |
Editorial: Paracetamol and the liver.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver; Liver Dis | 1976 |
Serum ferritin in patients with iron overload and with acute and chronic liver diseases.
Topics: Acetaminophen; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug | 1975 |
Experimental paracetamol-induced hepatic necrosis: a light- and electron-microscope, and histochemical study.
Topics: Acetaminophen; Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticu | 1975 |
Disturbances in glucose metabolism in patients with liver damage due to paracetamol overdose.
Topics: Acetaminophen; Adolescent; Adult; Aspartate Aminotransferases; Blood Glucose; Chemical and Drug Indu | 1975 |
Effect of liposomal entrapment on the protective action of glutathione against paracetamol-induced liver necrosis.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Glutathione; Liposomes; L | 1975 |
Serum transaminase levels after experimental paracetamol-induced hepatic necrosis.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1975 |
Proceedings: Antipyrine, lingocaine and paracetamol metabolism in chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Antipyrine; Chronic Disease; Female; Humans; Lidocaine; Liver Diseases; | 1975 |
Histopathological changes in the liver following a paracetamol overdose: correlation with clinical and biochemical parameters.
Topics: Acetaminophen; Adolescent; Adult; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Follow- | 1975 |
Immunolocalization of regenerating cells after submassive liver necrosis using PCNA staining.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Immunoh | 1992 |
31P magnetic resonance spectroscopy detects a functional abnormality in liver metabolism after acetaminophen poisoning.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Magnet | 1992 |
Hepatoprotective effects of lobenzarit disodium on acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dose-Response | 1992 |
Cysteine isopropylester protects against paracetamol-induced toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzo(a)pyrene; Chemical | 1992 |
Acetylcysteine and fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Biological Transport; Chemical and Drug Induced Liver Injury; Hemodyn | 1992 |
Recognizing acetaminophen hepatotoxicity in chronic alcoholics.
Topics: Acetaminophen; Alcoholism; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Ove | 1992 |
Glutamine preserves liver glutathione after lethal hepatic injury.
Topics: Acetaminophen; Analysis of Variance; Animals; Chemical and Drug Induced Liver Injury; Glutamine; Glu | 1992 |
Delayed calcium channel blockade with diltiazem reduces paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diltiaz | 1991 |
Acetaminophen induced pancreatitis.
Topics: Acetaminophen; Acute Disease; Adult; Ascites; Charcoal; Female; Humans; Ipecac; Kidney Diseases; Liv | 1991 |
The effect of chronic alcohol intake on prognosis and outcome in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alcoholism; Aspartate Aminotransferases; Brain Edema; Chemical | 1991 |
An improved model of acetaminophen-induced fulminant hepatic failure in dogs.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biopsy; Blood Glucose; Buthionine Sulfoximine; Chemica | 1992 |
Increased elastase-alpha 1-antitrypsin complex in fulminant hepatic failure: relationship to bacterial infection and activation of coagulation.
Topics: Acetaminophen; alpha 1-Antitrypsin; Aspartate Aminotransferases; Bacterial Infections; Bilirubin; Bl | 1991 |
[The protective effect of (4R)-hexahydro-7, 7-dimethyl-6-oxo-1, 2, 5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on acetaminophen-induced liver injury].
Topics: Acetaminophen; Animals; Azocines; Chemical and Drug Induced Liver Injury; Disulfides; Liver; Liver D | 1991 |
Liver transplantation after paracetamol overdose.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Decision Making; Drug Overdose; Female | 1991 |
Serum hyaluronate as a marker of hepatic derangement in acute liver damage.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Alanine Transaminase; Biomarkers; Child; Female; Hu | 1991 |
Failure of physicians to recognize acetaminophen hepatotoxicity in chronic alcoholics.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chemical | 1991 |
Tumour necrosis factor production in fulminant hepatic failure: relation to aetiology and superimposed microbial infection.
Topics: Acetaminophen; Adolescent; Adult; Bacterial Infections; Child; Female; Hepatitis, Viral, Human; Huma | 1990 |
Determination of the ketone body ratio in fulminant hepatic failure.
Topics: Acetaminophen; Energy Metabolism; Hepatitis, Viral, Human; Humans; Ketone Bodies; Liver; Liver Disea | 1990 |
Serial prothrombin time as prognostic indicator in paracetamol induced fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Live | 1990 |
Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Calcium; Cell Nucleus; Cell Survival; Chemical and Dru | 1990 |
Biphasic modulation of acetaminophen bioactivation and hepatotoxicity by pretreatment with the interferon inducer polyinosinic-polycytidylic acid.
Topics: Acetaminophen; Aging; Alanine Transaminase; Animals; Biotransformation; Chemical and Drug Induced Li | 1990 |
Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Allopurinol; Animals; Chemical and Drug | 1990 |
Can acetaminophen excess result in maternal and fetal toxicity?
Topics: Acetaminophen; Adult; Blood Coagulation Disorders; Cerebral Hemorrhage; Chemical and Drug Induced Li | 1990 |
Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?
Topics: Acetaminophen; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Glutathione; Hexobarbital; | 1990 |
Acetaminophen hepatotoxicity in the alcoholic.
Topics: Acetaminophen; Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Chemical and Dr | 1990 |
Early inhibition of the Na+/K+-ATPase ion pump during acetaminophen-induced hepatotoxicity in rat.
Topics: 5'-Nucleotidase; Acetaminophen; Alkylation; Animals; Cell Membrane; Chemical and Drug Induced Liver | 1987 |
Intrahepatic delivery of glutathione by conjugation to dextran.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Gel; Chromatography, | 1989 |
Early indicators of prognosis in fulminant hepatic failure.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Halothan | 1989 |
Plasma glutathione S-transferase and F protein are more sensitive than alanine aminotransferase as markers of paracetamol (acetaminophen)-induced liver damage.
Topics: Acetaminophen; Adult; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Glutathione Tran | 1989 |
Hepatoxicity evaluation in rats given a single overdose of Acetaminophen (Paracetamol).
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Liv | 1989 |
Computer-assisted predictive mathematical relationship among plasma acetaminophen concentration and time and hepatotoxicity in man.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Computer- | 1989 |
Effect of hepatic failure toxins on regenerative enzymes in the liver after injury with galactosamine in the rat.
Topics: Acetaminophen; Ammonium Chloride; Animals; Caprylates; Chemical and Drug Induced Liver Injury; Disul | 1989 |
Effect of acute and chronic propranolol administration on antipyrine and paracetamol clearance in patients with chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Antipyrine; Chronic Disease; Drug Administration Schedule; Female; Human | 1989 |
In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity.
Topics: Acetaminophen; Adjuvants, Immunologic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Live | 1989 |
Effect of hyperoxia on liver necrosis induced by hepatotoxins.
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cric | 1986 |
Protective effects of selenium on acetaminophen-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1988 |
A dog model for acetaminophen-induced fulminant hepatic failure.
Topics: Acetaminophen; Animals; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; Disease Mod | 1989 |
Does hypophosphatemia play a role in acute liver failure?
Topics: Acetaminophen; Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Fructose; Hepatic Enc | 1989 |
Effects of butylated hydroxyanisole on acetaminophen hepatotoxicity and glucuronidation in vivo.
Topics: Acetaminophen; Alanine; Animals; Anisoles; Aspartate Aminotransferases; Biotransformation; Butylated | 1986 |
Acetaminophen hepatotoxicity in rats is attenuated by silybin dihemisuccinate.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Flavonoids; Glutathione; Liver Disea | 1988 |
[Paracetamol poisoning in a swine model].
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotr | 1988 |
Hepatotoxicity after prolonged use of acetaminophen: a case report.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Diseases; Middle Aged | 1988 |
Acetaminophen-induced acute hepatic failure in pigs: controversical results to other animal models.
Topics: Acetaminophen; Acute Disease; Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Disease M | 1988 |
A 31P nuclear magnetic resonance study in vivo of metabolic abnormalities in rats with acute liver failure.
Topics: Acetaminophen; Acute Disease; Adenosine Triphosphate; Animals; Carbon Tetrachloride Poisoning; Chemi | 1988 |
Long-term sequellae of acetaminophen-associated fulminant hepatic failure: relevance of early histology.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Hep | 1988 |
Immediate rise in intracellular calcium and glycogen phosphorylase a activities upon acetaminophen covalent binding leading to hepatotoxicity in mice.
Topics: Acetaminophen; Administration, Oral; Animals; Buthionine Sulfoximine; Calcium; Chemical and Drug Ind | 1988 |
Severe liver damage caused by therapeutic doses of acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Alcohol Drinking; Aspartate Aminotransferases; Chemical and Dru | 1987 |
Effect of nutritional status on propylthiouracil-induced protection against acetaminophen hepatotoxicity in the rat.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Food; Food Deprivation; Liver Diseas | 1987 |
The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress.
Topics: Acetaminophen; Animals; Benzoquinones; Carmustine; Chemical and Drug Induced Liver Injury; Glutathio | 1987 |
[Extracorporeal hemoperfusion in acute fulminant hepatic failure associated with paracetamol poisoning].
Topics: Acetaminophen; Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Female; Hemoperfusion; | 1987 |
Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Cirrhosis | 1986 |
Alcohol, acetaminophen, and hepatic necrosis.
Topics: Acetaminophen; Adult; Alcoholism; Humans; Liver Diseases; Male; Necrosis | 1986 |
Anomalous susceptibility of the fasted hamster to acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Criceti | 1986 |
Effect of H2-receptor antagonists on acetaminophen-induced hepatic injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Famotidine; Glutathione; | 1986 |
[Paracetamol poisoning with fatal necrosis of the liver].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney Tubular Necrosis, Acut | 1986 |
Zinc abnormalities in fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Female; Hepatic Encephalopathy; Humans; Leukocytes; Liver Di | 1985 |
Plasma glutathione S-transferase measurements after paracetamol overdose: evidence for early hepatocellular damage.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Clinica | 1985 |
Increased hepatotoxicity of acetaminophen by concomitant administration of caffeine in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Dr | 1985 |
Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 1985 |
Effect of hepatic failure toxins on liver thymidine kinase activity and ornithine decarboxylase activity after massive necrosis with acetaminophen in the rat.
Topics: Acetaminophen; Animals; Caprylates; Chemical and Drug Induced Liver Injury; Disulfides; Hepatectomy; | 1985 |
Hepatic damage and death from overdose of paracetamol.
Topics: Acetaminophen; Adolescent; Adult; Aspartate Aminotransferases; Bilirubin; Biopsy; Blood Coagulation | 1973 |
Rapid removal of paracetamol by haemoperfusion through coated charcoal. In vivo and in-vitro studies in the pig.
Topics: Acetaminophen; Acrylic Resins; Adsorption; Animals; Charcoal; Liver Diseases; Methods; Perfusion; Sw | 1973 |
Successful treatment of severe paracetamol overdosage with cysteamine.
Topics: Acetaminophen; Adolescent; Adult; Bilirubin; Blood Cell Count; Blood Urea Nitrogen; Chemical and Dru | 1974 |
Effects of mepyramine, promethazine, and hydrocortisone on paracetamol-induced hepatic necrosis in the rat.
Topics: Acetaminophen; Animals; Benzyl Compounds; Chemical and Drug Induced Liver Injury; Ethylenediamines; | 1973 |
Fibrinogen in liver disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cholangitis; Cholestasis; Contusions; Endotox | 1974 |
Editorial: Towards an artificial liver.
Topics: Acetaminophen; Aspartic Acid; Brain Chemistry; Charcoal; Glutamates; Hepatic Encephalopathy; Hepatit | 1974 |
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; E | 1974 |
Coagulation abnormalities in acute liver failure; pathogenetic and therapeutic implications.
Topics: Acetaminophen; Acute Disease; Bilirubin; Biopsy; Blood Coagulation Disorders; Blood Coagulation Test | 1973 |
Hepatic encephalopathy.
Topics: Acetaminophen; Ammonia; Animals; Brain; Brain Edema; Diet Therapy; Dopamine; Female; Humans; Lactulo | 1973 |
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage.
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and | 1973 |
Acute acetaminophen poisoning.
Topics: Acetaminophen; Bilirubin; Blood Coagulation Disorders; Cardiomyopathies; Diuresis; Humans; Hypoglyce | 1973 |
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.
Topics: Acetaminophen; Animals; Carbon Radioisotopes; Cell Nucleus; Chemical and Drug Induced Liver Injury; | 1973 |
Disorderd hemostasis in liver damage from paracetamol overdose.
Topics: Acetaminophen; Adult; Bilirubin; Blood Cell Count; Blood Coagulation Tests; Blood Platelets; Chemica | 1973 |
Histological appearances in fulminant hepatic failure with reference to aetiology, time of survival and role of immunological processes.
Topics: Acetaminophen; Adolescent; Adult; Aged; Cell Nucleus; Chemical and Drug Induced Liver Injury; Haloth | 1973 |
The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Alanine Transaminase; Aspartate Aminotr | 1973 |
Frequency and type of renal and electrolyte disorders in fulminant hepatic failure.
Topics: Acetaminophen; Acute Kidney Injury; Blood Glucose; Chemical and Drug Induced Liver Injury; Creatinin | 1974 |
Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen.
Topics: Acetaminophen; Animals; Binding Sites; Chemical and Drug Induced Liver Injury; Cricetinae; Glutathio | 1974 |
Acetaminophen-induced hepatic necrosis and renal failure.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; H | 1971 |
Experimental paracetamol-induced hepatic necrosis: a histopathological study.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytoplasmic Granules; Liver; Liver D | 1971 |
Hepatic and renal damage with paractamol overdosage.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Liver; Liver Disease | 1968 |