acetaminophen has been researched along with Liver Cirrhosis in 57 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we present the case of a cystic fibrosis (CF) patient with preserved pulmonary function who developed acute liver failure requiring liver transplant following an episode of binge drinking and ingestion of a modest amount of acetaminophen." | 8.31 | Acute Liver Failure Triggered by Therapeutic Dose of Acetaminophen in a Patient with Cystic Fibrosis. ( Goodman, A; Grenn, EE; Koller, FL; Petrasek, J, 2023) |
| "A total of 125,505 patients with liver cirrhosis were registered from January 1, 2012 to December 31, 2012." | 5.43 | The Prescription Pattern of Acetaminophen and Non-Steroidal Anti-Inflammatory Drugs in Patients with Liver Cirrhosis. ( An, DS; Cho, M; Han, JH; Heo, J; Hong, YM; Lim, W; Woo, HY; Yoon, KT, 2016) |
| " Our patient presented with intentional acetaminophen overdose, received a transplant from a brain dead donor, and was confirmed brain dead 12 days posttransplant." | 5.12 | A Liver's Iliad: Liver Graft Retransplant to a Second Recipient After Brain Death in a First Recipient. ( Boira, MA; Ferreira, L; Maguire, D; Nair, S; Stafford, A, 2021) |
| "Phenacetin pharmacokinetics and the recovery of its urinary metabolites were studied in 8 normal subjects, 16 patients with chronic hepatitis B and 12 patients with cirrhosis." | 5.12 | Impaired clearance of phenacetin in hepatic cirrhosis and fibrosis. ( He, P; Li, XD; Liu, HL; Qu, ZQ; Wu, MC; Zhang, X, 2007) |
| " This review summarises the evidence for potential therapeutic applications of non-immunosuppressive cyclophilin inhibitors, alone or in combination with other agents, in virus-induced liver diseases like hepatitis C, B or Delta, liver inflammation and fibrosis, acetaminophen-induced liver toxicity and hepatocellular carcinoma." | 4.90 | Cyclophilin inhibition as potential therapy for liver diseases. ( Naoumov, NV, 2014) |
| "Here we present the case of a cystic fibrosis (CF) patient with preserved pulmonary function who developed acute liver failure requiring liver transplant following an episode of binge drinking and ingestion of a modest amount of acetaminophen." | 4.31 | Acute Liver Failure Triggered by Therapeutic Dose of Acetaminophen in a Patient with Cystic Fibrosis. ( Goodman, A; Grenn, EE; Koller, FL; Petrasek, J, 2023) |
| " Inflammation and fibrosis were evaluated by transaminases, myeloperoxidase activity, hydroxyproline, and histological evaluation." | 4.12 | Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease. ( Abrante, B; Abreu-González, P; de la Barreda, R; Díaz-Flores, F; González-Paredes, FJ; Hernández-Bustabad, A; Hernández-Guerra, M; Morales-Arraez, D; Quintero, E, 2022) |
| "Oral acetaminophen (1000 mg) was administered to seven healthy subjects and 14 patients with cirrhosis (nine Child-Pugh A or B and five Child-Pugh C grade), being five without and nine with oesophageal varices." | 3.72 | Pharmacokinetic variations of acetaminophen according to liver dysfunction and portal hypertension status. ( Carnicer, F; Esteban, A; Frances, R; Horga, JF; Lasso de la Vega, MC; Palazòn, JM; Pascual, S; Pérez-Mateo, M; Such, J; Zapater, P, 2004) |
| " Prior studies focused on pharmacokinetics (PK) of APAP in cirrhosis but did not rigorously examine clinical outcomes, sensitive biomarkers of liver damage, or serum APAP-protein adducts, which are a specific marker of toxic bioactivation." | 3.11 | Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis. ( Dranoff, JA; Fleming, DP; James, LP; Kennon-McGill, S; Mathews, SE; McCullough, SS; McGill, MR; Moran, JH; Peterson, EC; Spencer, HJ; Tripod, ME; Vazquez, JH, 2022) |
| "Pain management in patients with liver cirrhosis is a real challenge and is often inadequate due to a lack of therapeutic efficacy or the high incidence of adverse effects." | 2.50 | [Pain management in patients with liver cirrhosis]. ( Moreno, LA; Ojeda, A, 2014) |
| " In general, acetaminophen at reduced dosing is a safe option." | 2.46 | Pain management in the cirrhotic patient: the clinical challenge. ( Chandok, N; Watt, KD, 2010) |
| "Aspirin may cause a transient shedding of renal tubular cells, alterations in urate excretion, inhibition of spironolactone action, and, in certain clinical settings, a reversible decline in renal function manifested as a fall in glomerular filtration that may be accompanied by mild water, sodium, and potassium retention." | 2.36 | Acute effects of aspirin and acetaminophen on renal function. ( Kimberly, RP; Plotz, PH, 1981) |
| "Pain is common among cirrhosis patients, particularly those hospitalized with acute illness." | 1.91 | Cirrhosis Inpatients Receive More Opioids and Fewer Nonopioid Analgesics Than Patients Without Cirrhosis. ( Auerbach, A; Hohmann, SF; Lai, JC; Rubin, JB; Shui, AM, 2023) |
| "Liver fibrosis has been the focus and difficulty of medical research in the world and its concrete pathogenesis remains unclear." | 1.72 | HMGB1 induced endothelial to mesenchymal transition in liver fibrosis: The key regulation of early growth response factor 1. ( Huang, Z; Ji, L; Lu, B; Miao, H; Wei, M; Zhang, H; Zhang, T; Zhang, Y, 2022) |
| "Liver fibrosis is characterized by the accumulation of extracellular matrix (ECM) resulting in the formation of fibrous scars." | 1.62 | Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as Fibrosis-Specific Extracellular Biomarkers and Promoters of HSC Activation. ( Gaiser, C; Krähenbühl, S; Messner, CJ; Özkul, D; Schmidt, S; Suter-Dick, L; Terracciano, L, 2021) |
| " In summary, Nrf2 is critically involved in preventing liver fibrosis induced by long-term administration of APAP in mice, and Andro alleviates APAP-induced liver fibrosis by attenuating liver oxidative stress injury via inducing Nrf2 activation." | 1.48 | Natural product andrographolide alleviated APAP-induced liver fibrosis by activating Nrf2 antioxidant pathway. ( Bai, Q; Hao, Z; Huang, Z; Ji, L; Sheng, Y; Wang, Z; Yan, H, 2018) |
| "Patients with acute liver failure (ALF) have defects in innate immune responses to microbes (immune paresis) and are susceptible to sepsis." | 1.46 | Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure. ( Abeles, RD; Anderson, AE; Antoniades, CG; Auzinger, G; Bernal, W; Bernsmeier, C; El-Masry, A; Hou, TZ; Khamri, W; Kudo, N; Larsen, FS; Lebosse, F; Lombardi, G; Possamai, LA; Singanayagam, A; Thursz, M; Triantafyllou, E; Wendon, J; Weston, CJ; Willars, C, 2017) |
| " However, whether long-term administration of APAP will cause liver fibrosis is still not very clear." | 1.46 | Long-term acetaminophen treatment induced liver fibrosis in mice and the involvement of Egr-1. ( Bai, Q; Ji, L; Jin, Y; Sheng, Y; Shi, L; Wang, Z; Yan, H, 2017) |
| "A total of 125,505 patients with liver cirrhosis were registered from January 1, 2012 to December 31, 2012." | 1.43 | The Prescription Pattern of Acetaminophen and Non-Steroidal Anti-Inflammatory Drugs in Patients with Liver Cirrhosis. ( An, DS; Cho, M; Han, JH; Heo, J; Hong, YM; Lim, W; Woo, HY; Yoon, KT, 2016) |
| " Microarray data of rat PCLS exposed to APAP andCCl4was generated using a toxic dose based on decrease in ATP levels." | 1.42 | Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices. ( Elferink, ML; Groothuis, GM; Olinga, P; Schoonen, WG; Vatakuti, S, 2015) |
| "CCl4-induced liver fibrosis protects mice against lethal dose of APAP, Possibly by a mechanism involving inhibition of the cytoplasmic translocation of HMGB1." | 1.42 | [Protective effects and possible mechanisms of hepatic fibrosis against APAP-induced lethal injury]. ( Bai, L; Chen, Y; Duan, Z; Ren, F; Zhang, X; Zheng, S; Zu, K, 2015) |
| " These results will suggest that with repeated dosing of AAP special care must be taken in schistosomal patients since the elimination of AAP from plasma is remarkably reduced." | 1.29 | Acetaminophen plasma level after oral administration in liver cirrhotic patients suffering from schistosomal infection. ( el-Azab, G; Higashi, Y; Murakami, T; Yata, N; Youssef, MK, 1996) |
| " The average biological half-life after oral administration of 1 g paracetamol was significantly prolonged in patients with hepatic cirrhosis compared to the controls (3." | 1.26 | Paracetamol (acetaminophen) clearance in patients with cirrhosis of the liver. ( Andreasen, PB; Hutters, L, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (24.56) | 18.7374 |
| 1990's | 4 (7.02) | 18.2507 |
| 2000's | 11 (19.30) | 29.6817 |
| 2010's | 18 (31.58) | 24.3611 |
| 2020's | 10 (17.54) | 2.80 |
| Authors | Studies |
|---|---|
| McGill, MR | 1 |
| James, LP | 1 |
| McCullough, SS | 1 |
| Moran, JH | 1 |
| Mathews, SE | 1 |
| Peterson, EC | 1 |
| Fleming, DP | 1 |
| Tripod, ME | 1 |
| Vazquez, JH | 1 |
| Kennon-McGill, S | 1 |
| Spencer, HJ | 1 |
| Dranoff, JA | 1 |
| Messner, CJ | 1 |
| Schmidt, S | 1 |
| Özkul, D | 1 |
| Gaiser, C | 1 |
| Terracciano, L | 1 |
| Krähenbühl, S | 1 |
| Suter-Dick, L | 1 |
| Rubin, JB | 1 |
| Lai, JC | 1 |
| Shui, AM | 1 |
| Hohmann, SF | 1 |
| Auerbach, A | 1 |
| Wei, M | 1 |
| Zhang, Y | 1 |
| Zhang, H | 1 |
| Huang, Z | 2 |
| Miao, H | 1 |
| Zhang, T | 1 |
| Lu, B | 1 |
| Ji, L | 3 |
| Hernández-Bustabad, A | 1 |
| Morales-Arraez, D | 1 |
| González-Paredes, FJ | 1 |
| Abrante, B | 1 |
| Díaz-Flores, F | 1 |
| Abreu-González, P | 1 |
| de la Barreda, R | 1 |
| Quintero, E | 1 |
| Hernández-Guerra, M | 1 |
| Li, C | 1 |
| Ru, YJ | 1 |
| Lin, QY | 1 |
| Gao, GC | 1 |
| Yang, YD | 1 |
| Zhang, XQ | 1 |
| Gao, JL | 1 |
| Liu, SH | 1 |
| Zheng, CW | 1 |
| Wang, L | 1 |
| Zheng, YX | 1 |
| Wu, JM | 1 |
| Tropskaya, NS | 1 |
| Kislyakova, EA | 1 |
| Vilkova, IG | 1 |
| Kislitsyna, OS | 1 |
| Gurman, YV | 1 |
| Popova, TS | 1 |
| Baimatov, VN | 1 |
| Ghabril, M | 1 |
| Ma, J | 1 |
| Patidar, KR | 1 |
| Nephew, L | 1 |
| Desai, AP | 1 |
| Orman, ES | 1 |
| Vuppalanchi, R | 1 |
| Kubal, S | 1 |
| Chalasani, N | 1 |
| Boira, MA | 1 |
| Ferreira, L | 1 |
| Nair, S | 1 |
| Stafford, A | 1 |
| Maguire, D | 1 |
| Goodman, A | 1 |
| Grenn, EE | 1 |
| Koller, FL | 1 |
| Petrasek, J | 1 |
| Khamri, W | 1 |
| Abeles, RD | 1 |
| Hou, TZ | 1 |
| Anderson, AE | 1 |
| El-Masry, A | 1 |
| Triantafyllou, E | 1 |
| Bernsmeier, C | 1 |
| Larsen, FS | 1 |
| Singanayagam, A | 1 |
| Kudo, N | 1 |
| Possamai, LA | 1 |
| Lebosse, F | 1 |
| Auzinger, G | 1 |
| Bernal, W | 1 |
| Willars, C | 1 |
| Weston, CJ | 1 |
| Lombardi, G | 1 |
| Wendon, J | 1 |
| Thursz, M | 1 |
| Antoniades, CG | 1 |
| Yan, H | 2 |
| Bai, Q | 2 |
| Sheng, Y | 2 |
| Hao, Z | 1 |
| Wang, Z | 2 |
| Perugorria, MJ | 1 |
| Esparza-Baquer, A | 1 |
| Oakley, F | 1 |
| Labiano, I | 1 |
| Korosec, A | 1 |
| Jais, A | 1 |
| Mann, J | 1 |
| Tiniakos, D | 1 |
| Santos-Laso, A | 1 |
| Arbelaiz, A | 1 |
| Gawish, R | 1 |
| Sampedro, A | 1 |
| Fontanellas, A | 1 |
| Hijona, E | 1 |
| Jimenez-Agüero, R | 1 |
| Esterbauer, H | 1 |
| Stoiber, D | 1 |
| Bujanda, L | 1 |
| Banales, JM | 1 |
| Knapp, S | 1 |
| Sharif, O | 1 |
| Mann, DA | 1 |
| Hasenfuss, SC | 1 |
| Bakiri, L | 1 |
| Thomsen, MK | 1 |
| Hamacher, R | 1 |
| Wagner, EF | 1 |
| Edelman, EJ | 1 |
| Gordon, KS | 1 |
| Lo Re, V | 1 |
| Skanderson, M | 1 |
| Fiellin, DA | 1 |
| Justice, AC | 1 |
| Ojeda, A | 1 |
| Moreno, LA | 1 |
| Dwyer, JP | 1 |
| Jayasekera, C | 1 |
| Nicoll, A | 1 |
| Zheng, XY | 1 |
| Yang, YF | 1 |
| Li, W | 1 |
| Zhao, X | 1 |
| Sun, Y | 1 |
| Sun, H | 1 |
| Wang, YH | 1 |
| Pu, XP | 1 |
| Naoumov, NV | 1 |
| Zapater, P | 2 |
| Llanos, L | 1 |
| Barquero, C | 1 |
| Bellot, P | 1 |
| Pascual, S | 2 |
| Carnicer, F | 2 |
| Palazón, JM | 2 |
| Gimenez, P | 1 |
| Esteban, A | 2 |
| Llorca, L | 1 |
| Francés, R | 2 |
| Horga, JF | 2 |
| Such, J | 2 |
| Vatakuti, S | 1 |
| Schoonen, WG | 1 |
| Elferink, ML | 1 |
| Groothuis, GM | 1 |
| Olinga, P | 1 |
| Bai, L | 1 |
| Zu, K | 1 |
| Zhang, X | 2 |
| Ren, F | 1 |
| Zheng, S | 1 |
| Chen, Y | 1 |
| Duan, Z | 1 |
| Hong, YM | 1 |
| Yoon, KT | 1 |
| Heo, J | 1 |
| Woo, HY | 1 |
| Lim, W | 1 |
| An, DS | 1 |
| Han, JH | 1 |
| Cho, M | 1 |
| Stine, JG | 1 |
| Chalasani, NP | 1 |
| Yamamotoya, T | 1 |
| Nakatsu, Y | 1 |
| Matsunaga, Y | 1 |
| Fukushima, T | 1 |
| Yamazaki, H | 1 |
| Kaneko, S | 1 |
| Fujishiro, M | 1 |
| Kikuchi, T | 1 |
| Kushiyama, A | 1 |
| Tokunaga, F | 1 |
| Asano, T | 1 |
| Sakoda, H | 1 |
| Jin, Y | 1 |
| Shi, L | 1 |
| Khalid, SK | 1 |
| Lane, J | 1 |
| Navarro, V | 1 |
| Garcia-Tsao, G | 1 |
| Mehta, G | 1 |
| Rothstein, KD | 1 |
| Wang, XR | 1 |
| Qu, ZQ | 2 |
| Li, XD | 2 |
| Liu, HL | 2 |
| He, P | 2 |
| Fang, BX | 1 |
| Xiao, J | 1 |
| Huang, W | 1 |
| Wu, MC | 2 |
| Chandok, N | 1 |
| Watt, KD | 1 |
| Taurá, P | 1 |
| Fuster, J | 1 |
| Blasi, A | 1 |
| Martinez-Ocon, J | 1 |
| Anglada, T | 1 |
| Beltran, J | 1 |
| Balust, J | 1 |
| Tercero, J | 1 |
| Garcia-Valdecasas, JC | 1 |
| Kerr, R | 2 |
| Newsome, P | 1 |
| Germain, L | 1 |
| Thomson, E | 1 |
| Dawson, P | 1 |
| Stirling, D | 1 |
| Ludlam, CA | 1 |
| Lasso de la Vega, MC | 1 |
| Pérez-Mateo, M | 1 |
| Ford-Dunn, S | 1 |
| Guyot, C | 1 |
| Combe, C | 1 |
| Clouzeau-Girard, H | 1 |
| Moronvalle-Halley, V | 1 |
| Desmoulière, A | 1 |
| Watelet, J | 1 |
| Laurent, V | 1 |
| Bressenot, A | 1 |
| Bronowicki, JP | 1 |
| Larrey, D | 1 |
| Peyrin-Biroulet, L | 1 |
| Huet, PM | 1 |
| Giroux, L | 1 |
| Laurens, M | 1 |
| Crenesse, D | 1 |
| Misra, PK | 1 |
| Jain, MK | 1 |
| Kaul, R | 1 |
| Ali, B | 1 |
| Kaur, S | 1 |
| Bhargava, KP | 1 |
| Langley, PG | 1 |
| Hughes, RD | 1 |
| Williams, R | 1 |
| Benson, GD | 1 |
| Plotz, PH | 1 |
| Kimberly, RP | 1 |
| el-Azab, G | 1 |
| Youssef, MK | 1 |
| Higashi, Y | 1 |
| Murakami, T | 1 |
| Yata, N | 1 |
| Bernard, PH | 1 |
| Le Bail, B | 1 |
| Carles, J | 1 |
| Fawaz, R | 1 |
| Balabaud, C | 1 |
| Rosenbaum, J | 1 |
| Bioulac-Sage, P | 1 |
| Schiff, ER | 1 |
| Froomes, PR | 1 |
| Morgan, DJ | 1 |
| Smallwood, RA | 1 |
| Angus, PW | 1 |
| Eleftheriou, N | 1 |
| Heathcote, J | 1 |
| Thomas, HC | 1 |
| Sherlock, S | 2 |
| Andreasen, PB | 1 |
| Hutters, L | 1 |
| Ware, AJ | 1 |
| Upchurch, KS | 1 |
| Eigenbrodt, EH | 1 |
| Norman, DA | 1 |
| Arnman, R | 1 |
| Olsson, R | 1 |
| Prieto, J | 1 |
| Barry, M | 1 |
| Goranov, I | 1 |
| Avramova, K | 1 |
| Kaplowitz, N | 1 |
| Aw, TY | 1 |
| Simon, FR | 1 |
| Stolz, A | 1 |
| Wardle, EN | 1 |
| Walker, BE | 1 |
| Kelleher, J | 1 |
| Dixon, MF | 1 |
| Losowsky, MS | 1 |
| Hammar, CH | 1 |
| Prellwitz, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy and Safety of 36 Weeks Short-Term Optimization Treatment of Glucocorticosteroid in the Patients With Chronic Recurrent Drug-Induced Liver Injury[NCT03266146] | Phase 1/Phase 2 | 90 participants (Actual) | Interventional | 2017-09-02 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for acetaminophen and Liver Cirrhosis
| Article | Year |
|---|---|
A Liver's Iliad: Liver Graft Retransplant to a Second Recipient After Brain Death in a First Recipient.
Topics: Acetaminophen; Brain Death; Fibrosis; Graft Survival; Humans; Liver Cirrhosis; Liver Neoplasms; Live | 2021 |
[Pain management in patients with liver cirrhosis].
Topics: Acetaminophen; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Combined Modality Therap | 2014 |
Analgesia for the cirrhotic patient: a literature review and recommendations.
Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2014 |
Cyclophilin inhibition as potential therapy for liver diseases.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Cyclophil | 2014 |
Drug Hepatotoxicity: Environmental Factors.
Topics: Acetaminophen; Alcohol Drinking; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Envi | 2017 |
Health maintenance issues in cirrhosis.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Comorbidity; Disease Progression; Health | 2009 |
Pain management in the cirrhotic patient: the clinical challenge.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2010 |
New insights into haemostasis in liver failure.
Topics: Acetaminophen; Acute Disease; Antithrombins; Blood Coagulation Disorders; Blood Coagulation Factors; | 2003 |
Acute effects of aspirin and acetaminophen on renal function.
Topics: Acetaminophen; Aspirin; Humans; Indomethacin; Kidney; Kidney Failure, Chronic; Liver Cirrhosis; Lupu | 1981 |
Update in hepatology.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Hepatitis; Hepatitis, Viral, Human; Humans; Liver Cirrhosis | 1999 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
6 trials available for acetaminophen and Liver Cirrhosis
| Article | Year |
|---|---|
Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis.
Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Drug Administratio | 2022 |
Acute effects of dipyrone on renal function in patients with cirrhosis: a randomized controlled trial.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Ascit | 2015 |
Postoperative pain relief after hepatic resection in cirrhotic patients: the efficacy of a single small dose of ketamine plus morphine epidurally.
Topics: Acetaminophen; Adult; Aged; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Dissoc | 2003 |
Impaired clearance of phenacetin in hepatic cirrhosis and fibrosis.
Topics: Acetaminophen; Area Under Curve; Biotransformation; Carcinoma, Hepatocellular; Chemoembolization, Th | 2007 |
Comparative effects of oxygen supplementation on theophylline and acetaminophen clearance in human cirrhosis.
Topics: Acetaminophen; Adult; Female; Humans; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; | 1999 |
[The glucuronide pattern after peroral dosage with acetanilide in chronic hepatitis and liver cirrhosis].
Topics: Acetaminophen; Acetanilides; Glucosyltransferases; Glucuronates; Hepatitis; Humans; Liver; Liver Cir | 1966 |
40 other studies available for acetaminophen and Liver Cirrhosis
| Article | Year |
|---|---|
Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as Fibrosis-Specific Extracellular Biomarkers and Promoters of HSC Activation.
Topics: Acetaminophen; Actins; Caveolin 1; Cell Line; Extracellular Matrix; Gene Expression Regulation; Hepa | 2021 |
Cirrhosis Inpatients Receive More Opioids and Fewer Nonopioid Analgesics Than Patients Without Cirrhosis.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2023 |
HMGB1 induced endothelial to mesenchymal transition in liver fibrosis: The key regulation of early growth response factor 1.
Topics: Acetaminophen; Animals; Early Growth Response Protein 1; Endothelial Cells; Hepatic Stellate Cells; | 2022 |
Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease.
Topics: Acetaminophen; Acetylcholine; Animals; Hydroxyproline; Hypoxia; Inflammation; Intercellular Adhesion | 2022 |
Schisantherin D from Schisandra chinensis (Turcz.) Baill. exhibits anti-liver fibrosis capacity via modulating ETBR involved signaling, an in vitro and in vivo study.
Topics: Acetaminophen; Aflatoxin B1; Animals; Dioxoles; Humans; Lignans; Liver Cirrhosis; Mice; Molecular St | 2022 |
Experimental Model of Cirrhosis of the Liver.
Topics: Acetaminophen; Animals; Corn Oil; Dietary Fats; Female; Liver; Liver Cirrhosis; Models, Theoretical; | 2020 |
Eight-Fold Increase in Dietary Supplement-Related Liver Failure Leading to Transplant Waitlisting Over the Last Quarter Century in the United States.
Topics: Acetaminophen; Acute-On-Chronic Liver Failure; Chemical and Drug Induced Liver Injury; Child; Dietar | 2022 |
Acute Liver Failure Triggered by Therapeutic Dose of Acetaminophen in a Patient with Cystic Fibrosis.
Topics: Acetaminophen; Cystic Fibrosis; Humans; Liver Cirrhosis; Liver Diseases; Liver Failure, Acute; Lung; | 2023 |
Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure.
Topics: Acetaminophen; Acute-On-Chronic Liver Failure; Adaptive Immunity; Adult; Animals; Antibodies; B7-1 A | 2017 |
Natural product andrographolide alleviated APAP-induced liver fibrosis by activating Nrf2 antioxidant pathway.
Topics: Acetaminophen; Animals; Antioxidants; Collagen; Diterpenes; Hepatic Stellate Cells; Hydroxyproline; | 2018 |
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage.
Topics: Acetaminophen; Aged; Animals; Carbon Tetrachloride; Case-Control Studies; Female; Hematopoietic Stem | 2019 |
Activator Protein 1 transcription factor Fos-related antigen 1 (Fra-1) is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism.
Topics: Acetaminophen; Adaptation, Physiological; Animals; Bile Acids and Salts; Chemical and Drug Induced L | 2014 |
Acetaminophen receipt among HIV-infected patients with advanced hepatic fibrosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cross-Sectional Studies; Drug Prescriptions; Drug Utilizati | 2013 |
Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Cell Survival; | 2014 |
Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Gene Expression Profiling; Liver; Liver Cirrhosis; Mal | 2015 |
[Protective effects and possible mechanisms of hepatic fibrosis against APAP-induced lethal injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2015 |
The Prescription Pattern of Acetaminophen and Non-Steroidal Anti-Inflammatory Drugs in Patients with Liver Cirrhosis.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced | 2016 |
Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Carrier Proteins; Cell Line, Tumor; Disease | 2017 |
Long-term acetaminophen treatment induced liver fibrosis in mice and the involvement of Egr-1.
Topics: Acetaminophen; Actins; Alanine Transaminase; Analgesics; Animals; Aspartate Aminotransferases; Cell | 2017 |
Use of over-the-counter analgesics is not associated with acute decompensation in patients with cirrhosis.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Analgesics, Non-Narcotic; Anti-Infl | 2009 |
Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection.
Topics: Acetaminophen; Adult; Aged; Arylsulfotransferase; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A2 | 2010 |
Effects of acute liver injury on blood coagulation.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Antithrombin III; Blood Coagulation; Bloo | 2003 |
Pharmacokinetic variations of acetaminophen according to liver dysfunction and portal hypertension status.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Area Under Curve; Chromatography, Hig | 2004 |
Managing patients with cancer and advanced liver disease.
Topics: Acetaminophen; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma; Contraindicatio | 2005 |
Specific activation of the different fibrogenic cells in rat cultured liver slices mimicking in vivo situations.
Topics: Acetaminophen; Acetylcysteine; Animal Use Alternatives; Animals; Antioxidants; Bile Ducts, Intrahepa | 2007 |
Toxicity of chronic paracetamol ingestion.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Liver Cirrhosis; Male; Middle Aged | 2007 |
Effect of cold ischemia-warm reperfusion on the cirrhotic rat liver.
Topics: Acetaminophen; Animals; Bile; Disease Models, Animal; Endothelial Cells; Ischemia; L-Lactate Dehydro | 2008 |
Drug metabolism in Indian childhood cirrhosis.
Topics: Acetaminophen; Child, Preschool; Humans; Infant; Kinetics; Liver Cirrhosis; Phenacetin | 1984 |
Platelet adhesiveness to glass beads in liver disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chronic Disease; Glass; Hemoperfusion; Hepati | 1982 |
Acetaminophen in chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Double-Blind Method; Humans; Kinetics; Liver Cirrhosis; Male; Middle Age | 1983 |
Acetaminophen plasma level after oral administration in liver cirrhotic patients suffering from schistosomal infection.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aging; Analgesics, Non-Narcotic; Biological Availability; Bi | 1996 |
Morphology of hepatic stellate cells in patients with fulminant or subfulminant hepatitis requiring liver transplantation.
Topics: Acetaminophen; Actins; Adult; Aged; Amanita; Autoimmune Diseases; Biomarkers; Cell Differentiation; | 1996 |
Serum alpha-fetoprotein levels in patients with acute and chronic liver disease. Relation to hepatocellular regeneration and development of primary liver cell carcinoma.
Topics: Acetaminophen; Acute Disease; Adult; alpha-Fetoproteins; Carcinoma, Hepatocellular; Chronic Disease; | 1977 |
Paracetamol (acetaminophen) clearance in patients with cirrhosis of the liver.
Topics: Acetaminophen; Adult; Aged; Antipyrine; Female; Half-Life; Humans; Kinetics; Liver Cirrhosis; Liver | 1979 |
Acetaminophen and the liver.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Humans; Liver Cirrhosis; Male; Necrosi | 1978 |
Elimination of paracetamol in chronic liver disease.
Topics: Acetaminophen; Adolescent; Adult; Aged; Bilirubin; Humans; Liver Cirrhosis; Liver Neoplasms; Middle | 1978 |
Serum ferritin in patients with iron overload and with acute and chronic liver diseases.
Topics: Acetaminophen; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug | 1975 |
[Study of liver glucuronidase function in indirect hyperbilirubinemia and liver cirrhosis].
Topics: Acetaminophen; Bilirubin; Biological Transport; Free Radicals; Glucuronidase; Humans; Hyperbilirubin | 1975 |
Fibrinogen in liver disease.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cholangitis; Cholestasis; Contusions; Endotox | 1974 |
Vitamin E protection of the liver from paracetamol in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Female; Liver; Liver Cirr | 1974 |