acetaminophen has been researched along with Liver Cirrhosis, Biliary in 10 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Liver Cirrhosis, Biliary: FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cholangitis involves the destruction of small intra-hepatic bile ducts and decreased bile secretion. Secondary biliary cholangitis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The serologic hallmark of primary biliary cirrhosis (PBC) is the presence of antimitochondrial autoantibodies (AMAs) directed against the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2)." | 5.38 | Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? ( Coppel, RL; Gershwin, ME; Kurth, MJ; Lam, K; Leung, PS, 2012) |
| " Importantly, we have demonstrated that murine immunization with one such mimic, 2-octynoic acid coupled to bovine serum albumin (BSA), induces anti-mitochondrial antibodies (AMAs) and cholangitis." | 3.77 | Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity. ( Ansari, AA; Butler, JD; Coppel, RL; Gershwin, ME; Guggenheim, KG; Kenny, TP; Kurth, MJ; Lam, K; Leung, PS; López-Hoyos, M; Meng, L; Naiyanetr, P; Pfeiff, J; Reiger, R, 2011) |
| " The present study was conducted to investigate the expression of hepatobiliary efflux transporters in livers from patients after toxic acetaminophen (APAP) ingestion, with livers from patients with primary biliary cirrhosis (PBC) serving as positive controls." | 3.74 | Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases. ( Aleksunes, LM; Augustine, L; Barnes, SN; Cherrington, NJ; Goedken, MJ; Jakowski, AB; Manautou, JE; Pruimboom-Brees, IM; Scheffer, GL, 2007) |
| "To investigate the expression and activity of NAD(P)H quinone oxidoreductase 1 (NQO1) in human liver specimens obtained from patients with liver damage due to acetaminophen (APAP) overdose or primary biliary cirrhosis (PBC)." | 3.73 | Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury. ( Aleksunes, LM; Goedken, M; Manautou, JE, 2006) |
| "The serologic hallmark of primary biliary cirrhosis (PBC) is the presence of antimitochondrial autoantibodies (AMAs) directed against the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2)." | 1.38 | Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? ( Coppel, RL; Gershwin, ME; Kurth, MJ; Lam, K; Leung, PS, 2012) |
| "We found 26% with primary biliary cirrhosis were poor S-oxidisers, compared with 36% with other liver disease and 25% of healthy controls." | 1.29 | Sulphoxidation and sulphation capacity in patients with primary biliary cirrhosis. ( Davies, MH; Elias, E; Ngong, JM; Pean, A; Vickers, CR; Waring, RH, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naiyanetr, P | 2 |
| Butler, JD | 1 |
| Meng, L | 1 |
| Pfeiff, J | 1 |
| Kenny, TP | 2 |
| Guggenheim, KG | 1 |
| Reiger, R | 1 |
| Lam, K | 2 |
| Kurth, MJ | 3 |
| Ansari, AA | 1 |
| Coppel, RL | 2 |
| López-Hoyos, M | 1 |
| Gershwin, ME | 3 |
| Leung, PS | 3 |
| Wang, J | 1 |
| Lam, KS | 1 |
| Bischoff, A | 1 |
| Aleksunes, LM | 2 |
| Goedken, M | 1 |
| Manautou, JE | 2 |
| Barnes, SN | 1 |
| Augustine, L | 1 |
| Scheffer, GL | 1 |
| Goedken, MJ | 1 |
| Jakowski, AB | 1 |
| Pruimboom-Brees, IM | 1 |
| Cherrington, NJ | 1 |
| Arthurs, Y | 1 |
| Fielding, JF | 1 |
| Davies, MH | 1 |
| Ngong, JM | 1 |
| Pean, A | 1 |
| Vickers, CR | 1 |
| Waring, RH | 1 |
| Elias, E | 1 |
| Ryder, SD | 1 |
| Beckingham, IJ | 1 |
| Kaplowitz, N | 1 |
| Aw, TY | 1 |
| Simon, FR | 1 |
| Stolz, A | 1 |
2 reviews available for acetaminophen and Liver Cirrhosis, Biliary
| Article | Year |
|---|---|
ABC of diseases of liver, pancreas, and biliary system. Other causes of parenchymal liver disease.
Topics: Acetaminophen; Cholangitis, Sclerosing; Cholestasis; Drug Hypersensitivity; Hemochromatosis; Hepatit | 2001 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
8 other studies available for acetaminophen and Liver Cirrhosis, Biliary
| Article | Year |
|---|---|
Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoantibodies; Autoantigens; Autoi | 2011 |
Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis?
Topics: Acetaminophen; Animals; Autoantibodies; Autoimmunity; Humans; Liver Cirrhosis, Biliary; Mice; Mitoch | 2012 |
Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Autoantibodies; Binding Sites; Epitopes; Humans; Liver Cirr | 2013 |
[Increased quality of life--your patient does not tolerate his medication?].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug-Relate | 2004 |
Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Female; Gene Expression Regulation, Enzy | 2006 |
Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; ATP-Binding Cassette Transporters; | 2007 |
Paracetamol and chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Cirrhosis, | 1980 |
Sulphoxidation and sulphation capacity in patients with primary biliary cirrhosis.
Topics: Acetaminophen; Adult; Carbocysteine; Case-Control Studies; Cysteine; Female; Humans; Liver Cirrhosis | 1995 |