acetaminophen has been researched along with Lipidoses in 4 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phospholipidosis (PLD), an abnormal accumulation of phospholipids within tissues, is observed during the preclinical testing of many pharmaceutical drugs." | 1.38 | Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats. ( Colatsky, T; Mans, D; Rosenzweig, BA; Shea, K; Stewart, S; Thompson, KL; Zhang, J, 2012) |
| "Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types." | 1.36 | Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010) |
| " Thus, the protection against APAP toxicity afforded by deletion of both CYP2E1 and CYP1A2 likely reflects greatly diminished production of the toxic electrophile, NAPQI." | 1.30 | Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. ( Bruno, MK; Buters, JT; Cohen, SD; Gonzalez, FJ; Lucas, AM; Stern, ST; Ward, JM; Zaher, H, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lowe, R | 1 |
| Glen, RC | 1 |
| Mitchell, JB | 1 |
| Lu, J | 1 |
| Einhorn, S | 1 |
| Venkatarangan, L | 1 |
| Miller, M | 1 |
| Mann, DA | 1 |
| Watkins, PB | 1 |
| LeCluyse, E | 1 |
| Thompson, KL | 1 |
| Zhang, J | 1 |
| Stewart, S | 1 |
| Rosenzweig, BA | 1 |
| Shea, K | 1 |
| Mans, D | 1 |
| Colatsky, T | 1 |
| Zaher, H | 1 |
| Buters, JT | 1 |
| Ward, JM | 1 |
| Bruno, MK | 1 |
| Lucas, AM | 1 |
| Stern, ST | 1 |
| Cohen, SD | 1 |
| Gonzalez, FJ | 1 |
4 other studies available for acetaminophen and Lipidoses
| Article | Year |
|---|---|
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio | 2010 |
Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing.
Topics: Acetaminophen; Adult; Bile; Cells, Cultured; Chemical and Drug Induced Liver Injury; Female; Fluoroq | 2015 |
Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats.
Topics: Acetaminophen; Amiodarone; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Histocytoche | 2012 |
Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Cytochrome P-450 CYP1A2; Cyt | 1998 |