acetaminophen has been researched along with Kidney Papillary Necrosis in 32 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Kidney Papillary Necrosis: A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The nephrotoxicity of paracetamol (acetaminophen) administered to rats in doses of 300 mg/kg/day for periods up to 32 weeks was increased in the presence of experimentally induced pyelonephritis." | 3.66 | Experimental paracetamol nephropathy and pyelonephritis in rats. ( Furman, KI; Kündig, H; Lewin, JR, 1981) |
| "Analgesic nephropathy is part of a wider clinical syndrome associated with the abuse of APC compounds, that is, a minimum total intake of 2 kg of aspirin or phenacetin." | 3.65 | Analgesic nephropathy. ( Nanra, RS, 1976) |
| " In contrast, non-NSAID analgesics, such as paracetamol or tramadol, have essentially no renal or related cardiovascular side effects when used at recommended dosing schedules." | 2.41 | Renal and related cardiovascular effects of conventional and COX-2-specific NSAIDs and non-NSAID analgesics. ( Whelton, A, 2000) |
| " Groups of homozygotes were dosed by gavage with aspirin, phenacetin and paracetamol for 4 weeks." | 1.25 | The induction of renal papillary necrosis in Gunn rats by analgesics and analgesic mixtures. ( Axelsen, RA, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (84.38) | 18.7374 |
| 1990's | 3 (9.38) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nasr, LA | 1 |
| Haydar, AA | 1 |
| Krikler, DM | 1 |
| Hoffnung, JM | 1 |
| Parker, MD | 1 |
| Hartz, JW | 1 |
| Segasothy, M | 2 |
| Tong, BK | 1 |
| Kamal, A | 2 |
| Murad, Z | 1 |
| Suleiman, AB | 1 |
| Henry, MA | 2 |
| Sweet, RS | 1 |
| Tange, JD | 2 |
| Offerhaus, L | 2 |
| Duggin, GG | 1 |
| Furman, KI | 1 |
| Kündig, H | 1 |
| Lewin, JR | 1 |
| Zollinger, HU | 1 |
| Nanra, RS | 2 |
| Daniel, V | 1 |
| Howard, M | 1 |
| Whelton, A | 1 |
| Molland, EA | 1 |
| Murray, T | 1 |
| Goldberg, M | 1 |
| Rumack, BH | 1 |
| Matthew, H | 1 |
| Axelsen, RA | 1 |
| Burrell, JH | 2 |
| Yong, JL | 2 |
| Macdonald, GJ | 2 |
| Gregg, NJ | 1 |
| Robbins, ME | 1 |
| Hopewell, JW | 1 |
| Bach, PH | 2 |
| Carlton, WW | 1 |
| Engelhardt, JA | 1 |
| McCredie, M | 1 |
| Stewart, JH | 1 |
| Muhaya, HM | 1 |
| Musa, A | 1 |
| Rajagopalan, K | 1 |
| Lim, KJ | 1 |
| Fatimah, Y | 1 |
| Ahmad, KS | 1 |
| Bridges, JW | 1 |
| Allen, RC | 1 |
| Petty, RE | 1 |
| Lirenman, DS | 1 |
| Malleson, PN | 1 |
| Laxer, RM | 1 |
| Bengtsson, V | 1 |
| Wigley, RD | 1 |
| Barraclough, MA | 1 |
| Kincaid-Smith, P | 1 |
6 reviews available for acetaminophen and Kidney Papillary Necrosis
| Article | Year |
|---|---|
Mechanisms in the development of analgesic nephropathy.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Synergism; Humans; Ki | 1980 |
Renal and related cardiovascular effects of conventional and COX-2-specific NSAIDs and non-NSAID analgesics.
Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antihyperte | 2000 |
Analgesic abuse and renal disease.
Topics: Acetaminophen; Adult; Aged; Animals; Aspirin; Creatinine; Drug Combinations; Humans; Inactivation, M | 1975 |
Chemically induced renal papillary necrosis and upper urothelial carcinoma. Part 1.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Carbohy | 1985 |
Unravelling analgesic nephropathy.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Carcinoma, Transitional Cell; Female; Humans; Kidney Ne | 1972 |
Aspirin and the kidney.
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Humans; Kidney; Kidney Diseases; Kidney Papillary Nec | 1971 |
1 trial available for acetaminophen and Kidney Papillary Necrosis
| Article | Year |
|---|---|
Effect of vasopressin on the reabsorption of phenacetin and its metabolites from the tubular fluid in man.
Topics: Acetaminophen; Aniline Compounds; Creatinine; Diuresis; Humans; Kidney Papillary Necrosis; Kidney Tu | 1972 |
25 other studies available for acetaminophen and Kidney Papillary Necrosis
| Article | Year |
|---|---|
Plain film signs of sickle β-thalassaemia.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anemia, Sickle Cell; beta-Thalassemia; Female; Hemat | 2017 |
Paracetamol and the kidney.
Topics: Acetaminophen; Adult; Cystoscopy; Humans; Kidney Papillary Necrosis; Male; Phenacetin; Urography | 1967 |
Papillary necrosis mimicking staghorn calculi.
Topics: Acetaminophen; Calcinosis; Dextropropoxyphene; Diagnosis, Differential; Female; Humans; Kidney Calcu | 1982 |
Analgesic nephropathy associated with paracetamol.
Topics: Acetaminophen; Adult; Aged; Female; Humans; Kidney Diseases; Kidney Failure, Chronic; Kidney Functio | 1984 |
A new reproducible experimental model of analgesic nephropathy.
Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Aspirin; Disease Models, Animal; Female; Kidney; Kid | 1983 |
[How safe is paracetamol?].
Topics: Acetaminophen; Animals; Drug Combinations; Humans; Kidney Papillary Necrosis; Nephritis, Interstitia | 1983 |
Experimental paracetamol nephropathy and pyelonephritis in rats.
Topics: Acetaminophen; Animals; Female; Kidney Diseases; Kidney Papillary Necrosis; Pyelonephritis; Rats; Ra | 1981 |
[25 years of phenacetin abuse].
Topics: Acetaminophen; Humans; Kidney Papillary Necrosis; Legislation, Drug; Nephritis, Interstitial; Phenac | 1980 |
[Phenacetin or paracetamol?].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Prescriptions; Humans; Kidney Papillary | 1980 |
Analgesic nephropathy induced by common proprietary mixtures.
Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Caffeine; Drug Combinations; Female; Humans; Kidney | 1980 |
Experimental renal papillary necrosis.
Topics: Acetaminophen; Animals; Aspirin; Body Weight; Drug Combinations; Female; Kidney Cortex; Kidney Medul | 1978 |
Analgesic nephropathy.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Co | 1976 |
Acetaminophen poisoning and toxicity.
Topics: Acetaminophen; Agranulocytosis; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Hypoglyc | 1975 |
The induction of renal papillary necrosis in Gunn rats by analgesics and analgesic mixtures.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Caffeine; Female; Heterozygote; Homozygote; Kidney Papi | 1975 |
Analgesic nephropathy in Fischer 344 rats: comparative effects of chronic treatment with either aspirin or paracetamol.
Topics: Acetaminophen; Animals; Aspirin; Female; Incidence; Kidney Concentrating Ability; Kidney Diseases; K | 1991 |
Irreversible damage to the medullary interstitium in experimental analgesic nephropathy in F344 rats.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Disease Models, Animal; Female; Kidney Concentrating Ab | 1991 |
The effect of acetaminophen on pig kidneys with a 2-bromoethanamine-induced papillary necrosis.
Topics: Acetaminophen; Age Factors; Animals; Disease Models, Animal; Ethylamines; Female; Glomerular Filtrat | 1990 |
Experimental renal papillary necrosis in the Syrian hamster.
Topics: Acetaminophen; Animals; Cricetinae; Disease Models, Animal; Ethylamines; Indomethacin; Kidney Medull | 1989 |
Does paracetamol cause urothelial cancer or renal papillary necrosis?
Topics: Acetaminophen; Carcinoma, Transitional Cell; Female; Humans; Kidney Neoplasms; Kidney Papillary Necr | 1988 |
Lesions of the renal papilla induced by paracetamol.
Topics: Acetaminophen; Animals; Aspirin; Drug Synergism; Female; Kidney Cortex; Kidney Medulla; Kidney Papil | 1987 |
Analgesic use by leprosy patients.
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Female; Humans; Kidney Papillary Necrosis; Leprosy; | 1986 |
Renal papillary necrosis in children with chronic arthritis.
Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents; Arthritis, Juvenile; Child; Child, Preschool; F | 1986 |
Phenacetin.
Topics: Acetaminophen; Antipyrine; Denmark; Humans; Kidney Diseases; Kidney Neoplasms; Kidney Papillary Necr | 1969 |
Acetaminophen, valadol, and analgesic renal injury.
Topics: Acetaminophen; Analgesics; Aspirin; Humans; Kidney Diseases; Kidney Papillary Necrosis; Nephritis, I | 1971 |
Analgesic nephropathy. A common form of renal disease in Australia.
Topics: Acetaminophen; Analgesics; Anemia; Animals; Aspirin; Australia; Caffeine; Diagnosis, Differential; D | 1969 |