acetaminophen has been researched along with Kidney Diseases in 220 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This paper reviews the reported data related to the effects of diabetes and hypertriglyceridemia, common lifestyle-related diseases in a modern society, on acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity in rats and mice." | 8.85 | Diabetes and hypertriglyceridemia modify the mode of acetaminophen-induced hepatotoxicity and nephrotoxicity in rats and mice. ( Doi, K; Ishida, K, 2009) |
| " Acetaminophen treatment decreased renal lipid deposition, ER-stress related signaling, apoptosis and albuminuria." | 7.80 | Acetaminophen attenuates obesity-related renal injury through ER-mediated stress mechanisms. ( Arvapalli, R; Blough, E; Dai, X; Driscoll, H; Mahmood, M; Rice, KM; Wang, C; Wu, M, 2014) |
| "This is the fourth reported case of acute pancreatitis associated with acetaminophen overdose." | 7.68 | Acetaminophen induced pancreatitis. ( Caraccio, TR; Mofenson, HC; Nawaz, H; Steckler, G, 1991) |
| " Children with a febrile illness were enrolled from outpatient pediatric and family medicine practices and randomly assigned to receive either acetaminophen suspension or one of two dosages of ibuprofen suspension (5 mg/kg or 10 mg/kg) for fever control." | 5.08 | Renal function after short-term ibuprofen use in infants and children. ( Lesko, SM; Mitchell, AA, 1997) |
| " This paper reviews the reported data related to the effects of diabetes and hypertriglyceridemia, common lifestyle-related diseases in a modern society, on acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity in rats and mice." | 4.85 | Diabetes and hypertriglyceridemia modify the mode of acetaminophen-induced hepatotoxicity and nephrotoxicity in rats and mice. ( Doi, K; Ishida, K, 2009) |
| "To assess the efficacy of cyclooxygenase-2 selective inhibitors (coxibs) in osteoarthritis (OA) and their gastrointestinal, cardiovascular, renovascular, and hepatic side effects compared with traditional nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen." | 4.84 | COX-2 selective inhibitors in the treatment of osteoarthritis. ( Hochberg, M; Laine, L; Rostom, A; White, WB, 2008) |
| " Acetaminophen treatment decreased renal lipid deposition, ER-stress related signaling, apoptosis and albuminuria." | 3.80 | Acetaminophen attenuates obesity-related renal injury through ER-mediated stress mechanisms. ( Arvapalli, R; Blough, E; Dai, X; Driscoll, H; Mahmood, M; Rice, KM; Wang, C; Wu, M, 2014) |
| " Acetaminophen is a commonly used analgesic and antipyretic agent which, at high doses, causes liver and kidney necrosis in man and animals." | 3.77 | Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis. ( Kumar, BS; Kumar, RP; Palani, S; Raja, S; Selvaraj, R, 2011) |
| "Acetaminophen is an effective mild analgesic and antipyretic agent." | 3.74 | Acetaminophen. ( Ameer, B; Greenblatt, DJ, 1977) |
| "To compare the hepatic and renal safety profiles of two daily dosage regimens of paracetamol (acetaminophen) (3 g versus 4 g) in patients with painful chronic rheumatoid diseases." | 3.71 | [Liver and renal tolerance to paracetamol: 3 g or 4 g per day?]. ( Ganry, H; Pruvot, F; Schmidely, N; Vesque, D, 2001) |
| "To assess the epidemiology of habitual use of analgesics in South-West Germany (i) urine specimens of employees of a factory, of patients seen by a general practitioner (GP) and of patients attending a renal clinic were examined for paracetamol; (ii) mucosa of the left renal pelvis was examined for the presence of capillary sclerosis as an index of habitual use of phenacetin or paracetamol in 258 consecutive autopsies; (iii) in a regional renal clinic, the frequency of analgesic nephropathy was determined amongst outpatients and amongst patients on hemodialysis." | 3.68 | [Epidemiological studies of the frequency of the abuse of analgesics]. ( de Vries, JX; Küster, G; Mohr, T; Rieser, PF; Ritz, E; Waldherr, R; Walter-Sack, J, 1990) |
| "This is the fourth reported case of acute pancreatitis associated with acetaminophen overdose." | 3.68 | Acetaminophen induced pancreatitis. ( Caraccio, TR; Mofenson, HC; Nawaz, H; Steckler, G, 1991) |
| "The nephrotoxicity of paracetamol (acetaminophen) administered to rats in doses of 300 mg/kg/day for periods up to 32 weeks was increased in the presence of experimentally induced pyelonephritis." | 3.66 | Experimental paracetamol nephropathy and pyelonephritis in rats. ( Furman, KI; Kündig, H; Lewin, JR, 1981) |
| " There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis." | 3.65 | Lysozymuria and acute disorders of renal function. ( De Silva, KL; Harrison, JF; Parker, RW, 1973) |
| "Analgesic nephropathy is part of a wider clinical syndrome associated with the abuse of APC compounds, that is, a minimum total intake of 2 kg of aspirin or phenacetin." | 3.65 | Analgesic nephropathy. ( Nanra, RS, 1976) |
| "A survey of 763 patients with rheumatoid arthritis and 145 with osteoarthritis in six clinics in New Zealand showed no association between aspirin intake and a score designed to detect analgesic nephropathy." | 3.65 | Aspirin and the kidney. New Zealand Rheumatism Association Study. ( , 1974) |
| " On the basis of performed investigations it may be assumed that the determination of these parameters in urine will enable early detection of changes in the kidneys occurring under the influence of toxic doses of paracetamol and prevent their further development due to appropriate therapeutic management." | 2.72 | [Selected biochemical parameters of urine in the evaluation of paracetamol nephrotoxicity]. ( Długosz, A; Kochman, K; Lepka, M; Marchewka, Z; Przewłocki, M, 2006) |
| " Although effective, these agents can be associated with adverse effects that may limit their use in some people." | 2.58 | Cardiorenal Safety of OTC Analgesics. ( Angiolillo, DJ; Davidson, MH; Kloner, RA; White, WB, 2018) |
| " However, the dose-response seen for most endpoints suggests a considerable degree of paracetamol toxicity especially at the upper end of standard analgesic doses." | 2.53 | Paracetamol: not as safe as we thought? A systematic literature review of observational studies. ( Bernstein, I; Birrell, F; Buckner, S; Conaghan, PG; Constanti, M; Delgado Nunes, V; Doherty, M; Dziedzic, K; Latchem, S; Miller, P; Porcheret, M; Roberts, E; Wise, E; Zhang, W, 2016) |
| "Acetaminophen is a commonly-used analgesic in the US and, at doses of more than 4 g/day, can lead to serious hepatotoxicity." | 2.50 | A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States. ( Ben-Joseph, R; Blieden, M; Paramore, LC; Shah, D, 2014) |
| " Because NSAIDs are associated with adverse renal effects, they should be used cautiously in patients with advanced renal disease." | 2.43 | Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease. ( Johnson, J; Weinryb, J, 2006) |
| "Approximately 75% of patients with tuberous sclerosis complex develop renal angiomyolipomas." | 2.41 | Reduction of postembolization syndrome after ablation of renal angiomyolipoma. ( Bissler, JJ; Donnelly, LF; Johnson, ND; Racadio, J, 2002) |
| " However, chronic use of high doses of paracetamol should be avoided, probably also consumption of paracetamol in combination with ASA." | 2.39 | [Paracetamol--kidney and urinary tract. A cause of analgetic nephropathy or cancer?]. ( Berg, KJ, 1994) |
| "Fluid and electrolyte disturbances, acute renal failure, and acute interstitial nephritis also occur predominantly with NSAIDs." | 2.39 | Renal effects of over-the-counter analgesics. ( Whelton, A, 1995) |
| " Data are presented in 46 patients who took aspirin continuously for 10 or more years (mean total dosage 35 kg) in whom there was no evidence of significant renal dysfunction." | 2.36 | Aspirin and renal disease. ( Emkey, RD, 1983) |
| "Acetaminophen (APAP) is one of the popular and safe pain medications worldwide." | 1.91 | Acetaminophen-Induced Nephrotoxicity: Suppression of Apoptosis and Endoplasmic Reticulum Stress Using Boric Acid. ( Aytuğ, H; Çoban, FK; Demirel, HH; İnce, S; İslam, İ, 2023) |
| " Our results clarified that Paracetamol toxicity caused significant adverse effects on hematological, serum biochemical parameters, and oxidant -antioxidant status as well as histopathological picture of heart, liver, and kidney." | 1.62 | Protective role of Chlorella vulgaris with Thiamine against Paracetamol induced toxic effects on haematological, biochemical, oxidative stress parameters and histopathological changes in Wistar rats. ( Alkhalifah, DHM; Assar, DH; Elkaw, EM; Hamouda, RA; Hamza, HA; Hozzein, WN; Latif, AAE, 2021) |
| " Drug-induced toxicity can be relieved by several natural products, which are preferred due to their dietary nature and less adverse reactions." | 1.56 | Omega-3 fatty acids protect against acetaminophen-induced hepatic and renal toxicity in rats through HO-1-Nrf2-BACH1 pathway. ( Abo El-Magd, NF; Eraky, SM, 2020) |
| "The postnatal end points included patent ductus arteriosus (PDA), primary pulmonary hypertension (PPHT), and impaired renal function." | 1.51 | Negligible risk of prenatal ductus arteriosus closure or fetal renal impairment after third-trimester paracetamol use: evaluation of the German Embryotox cohort. ( Beck, E; Dathe, K; Frank, J; Hultzsch, S; Meister, R; Meixner, K; Padberg, S; Schaefer, C, 2019) |
| "Diallyl disulfide (DADS) is a degradation product of allicin which is contained in garlic." | 1.46 | Protective effects of diallyl disulfide against acetaminophen-induced nephrotoxicity: A possible role of CYP2E1 and NF-κB. ( Kim, JC; Kim, JW; Kim, SH; Ko, JW; Lee, IC; Moon, C; Park, SH; Shin, IS; Shin, JY; Shin, NR, 2017) |
| "Naringin pretreatment significantly decreased (p < 0." | 1.43 | Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1. ( Adil, M; Bodhankar, SL; Ghosh, P; Kandhare, AD; Raygude, KS; Venkata, S, 2016) |
| " Cumulative APAP dosage greater than 1 kg and APAP use for longer than 30 days in the pre-index year were not significantly associated with an increased risk of renal disease (both P values = 0." | 1.38 | Acute and chronic acetaminophen use and renal disease: a case-control study using pharmacy and medical claims. ( Cleves, MA; Foster, HR; Hogan, WR; James, LP; Kelkar, M; Martin, BC, 2012) |
| "High neopterin levels have been accepted as strong indicators for the clinical severity of some diseases." | 1.36 | The association between neopterin and acetaminophen-induced nephrotoxicity. ( Agilli, M; Akgul, OE; Aydin, FN; Aydin, I; Bilgi, C; Bilgic, S; Cakir, E; Cayci, T; Erbil, KM; Ersoz, N; Guven, A; Kurt, YG; Onguru, O; Turker, T; Yaman, H, 2010) |
| "Acetaminophen (APAP), also known as paracetamol, is the commonest cause of toxic ingestion in the world." | 1.36 | Effects of medical ozone therapy on acetaminophen-induced nephrotoxicity in rats. ( Cayci, T; Demirbag, S; Guven, A; Kaldirim, U; Korkmaz, A; Ozcan, A; Ozler, M; Surer, I; Uysal, B, 2010) |
| "Acetaminophen (APAP) is an analgesic-antipyretic drug widely used in children." | 1.36 | Heat shock protein 70 induction and its urinary excretion in a model of acetaminophen nephrotoxicity. ( Molinas, SM; Monasterolo, LA; Pagotto, MA; Pisani, GB; Rosso, M; Trumper, L; Wayllace, NZ, 2010) |
| "Acetaminophen (APAP) can cause life-threatening renal damages and there is no specific treatment for APAP-induced renal damage." | 1.35 | Curcumin prevents oxidative renal damage induced by acetaminophen in rats. ( Cekmen, M; Ersoz, C; Ilbey, YO; Ozbek, E; Simsek, A; Somay, A, 2009) |
| "Erdosteine treated APAP groups showed milder tubular degeneration, epithelial vacuolization in the proximal tubules, lesser cellular desquamation and better morphology when compared with APAP groups." | 1.33 | Erdosteine against acetaminophen induced renal toxicity. ( Akcay, A; Bayrak, R; Isik, B; Sogut, S, 2006) |
| "Propylthiouracil (PTU) has been shown to be protective against acetaminophen (APAP)-induced liver damage in rats; however, the nephroprotective effect of propylthiouracil has not been studied yet." | 1.33 | Propylthiouracil attenuates acetaminophen-induced renal damage in the rat. ( Abraham, P; Dian, BJ; Kanakasabapathy, I, 2005) |
| " Indeed, pretreatment of male CD-1 mice with APAP-CYS before challenge with a threshold toxic dose of APAP resulted in significant enhancement of APAP-induced nephrotoxicity." | 1.33 | Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity in CD-1 mice: I. Enhancement of acetaminophen nephrotoxicity by acetaminophen-cysteine. ( Bruno, MK; Cohen, SD; Hennig, GE; Horton, RA; Roberts, JC; Stern, ST, 2005) |
| " This APAP-CYS-induced renal GSH depletion could interfere with intrarenal detoxification of APAP or its toxic metabolite N-acetyl-p-benzoquinoneimine (NAPQI) and may be the mechanism responsible for the potentiation of APAP nephrotoxicity." | 1.33 | Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity II. Possible involvement of the gamma-glutamyl cycle. ( Bruno, MK; Cohen, SD; Hill, DW; Horton, RA; Roberts, JC; Stern, ST, 2005) |
| "Chloroquine has marked effects on the normal kidney and stimulates an increase in plasma vasopressin via nitric oxide." | 1.32 | Renal function in a rat model of analgesic nephropathy: effect of chloroquine. ( Ahmed, MH; Ashton, N; Balment, RJ, 2003) |
| "To understand the bioavailability and mechanistic pathways of cytoprotection by IH636 grape seed proanthocyanidin extract (GSPE, commercially known as ActiVin) a series of in vitro and in vivo studies were conducted." | 1.31 | Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. ( Bagchi, D; Bagchi, M; Preuss, HG; Ray, SD; Stohs, SJ, 2002) |
| "Probenecid pretreatment promoted an elevation in the urinary 16-hr excretion of APAP and a diminution in the plasma levels attained by APAP." | 1.30 | Probenecid protects against In vivo acetaminophen-induced nephrotoxicity in male Wistar rats. ( Elías, MM; Monasterolo, LA; Trumper, L, 1998) |
| " Plasma concentrations were measured in four additional animals of all high dose groups after the last dosing at seven time points." | 1.29 | Studies on the chronic oral toxicity of an analgesic drug combination consisting of acetylsalicylic acid, paracetamol and caffeine in rats including an electron microscopical evaluation of kidneys. ( Bauer, E; Bauer, M; Greischel, A; Hirsch, U; Lehmann, H; Schmid, J; Schneider, P, 1996) |
| " These studies indicate that glutathione conjugation of PAP generates a metabolite that is more toxic to the kidney than the parent compound." | 1.28 | Nephrotoxicity of 4-aminophenol glutathione conjugate. ( Foster, JR; Fowler, LM; Lock, EA; Moore, RB, 1991) |
| " Pharmacokinetic variables were evaluated following i." | 1.28 | Strain differences in acetaminophen nephrotoxicity in rats: role of pharmacokinetics. ( Goldstein, RS; Hook, JB; Tarloff, JB, 1989) |
| "Eighteen patients in hepatic coma grade III-IV were entered in the study and were divided into two groups in accordance with their renal function (serum creatinine above/below 180 mumol/l)." | 1.28 | Fractional excretion of beta-2-microglobulin in the urine of patients with normal or reduced renal function and hepatic coma. ( Dalhoff, K; Hansen, PB; Joffe, P; Olesen, B, 1991) |
| "Acetaminophen was administered in the food at an average dose of 900 mg/kg and Cd in drinking water at the concentration of 200 ppm." | 1.27 | Potentiation of cadmium nephrotoxicity by acetaminophen. ( Amor, AO; Bernard, AM; de Russis, R; Lauwerys, RR, 1988) |
| "Since all these patients were alcohol abusers, and the reported paracetamol intake was not remarkably high, it seems reasonable to recommend that paracetamol should be prescribed with great caution to alcoholics, and absolutely not for continuous use." | 1.27 | Paracetamol medication and alcohol abuse: a dangerous combination for the liver and the kidney. ( Denison, H; Kaczynski, J; Wallerstedt, S, 1987) |
| "In patients with preeclampsia the renal excretion of beta 2-microglobulin allows to differentiate between a primary preeclampsia and a preeclampsia superimposed upon chronic pyelonephritis." | 1.26 | Beta 2-microglobulin and other proteins as parameter for tubular function. ( Jaques, G; Keller, M; Mondorf, AW; Prüfer, D; Weise, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 89 (40.45) | 18.7374 |
| 1990's | 40 (18.18) | 18.2507 |
| 2000's | 50 (22.73) | 29.6817 |
| 2010's | 33 (15.00) | 24.3611 |
| 2020's | 8 (3.64) | 2.80 |
| Authors | Studies |
|---|---|
| Fernando, CR | 1 |
| Calder, IC | 2 |
| Ham, KN | 2 |
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Sridharan, K | 1 |
| Al Jufairi, M | 1 |
| Al Segai, O | 1 |
| Al Ansari, E | 1 |
| Hashem Ahmed, H | 1 |
| Husain Shaban, G | 1 |
| Malalla, Z | 1 |
| Al Marzooq, R | 1 |
| Al Madhoob, A | 1 |
| Saeed Tabbara, K | 1 |
| Çoban, FK | 1 |
| İnce, S | 1 |
| Demirel, HH | 1 |
| İslam, İ | 1 |
| Aytuğ, H | 1 |
| Zhang, X | 1 |
| Long, F | 1 |
| Li, R | 1 |
| Yang, Y | 1 |
| Wang, T | 1 |
| He, Q | 1 |
| Xu, M | 1 |
| Wang, L | 1 |
| Jiang, X | 1 |
| Eraky, SM | 1 |
| Abo El-Magd, NF | 1 |
| Koyuncuoğlu, T | 1 |
| Yıldırım, A | 1 |
| Dertsiz, EK | 1 |
| Yüksel, M | 1 |
| Ercan, F | 1 |
| Yeğen, BÇ | 1 |
| Ihedioha, JI | 1 |
| Anyogu, DC | 1 |
| Ogbonna, ME | 1 |
| Rawls, KD | 1 |
| Dougherty, BV | 1 |
| Vinnakota, KC | 1 |
| Pannala, VR | 1 |
| Wallqvist, A | 1 |
| Kolling, GL | 1 |
| Papin, JA | 1 |
| Latif, AAE | 1 |
| Assar, DH | 1 |
| Elkaw, EM | 1 |
| Hamza, HA | 1 |
| Alkhalifah, DHM | 1 |
| Hozzein, WN | 1 |
| Hamouda, RA | 1 |
| Hadzi-Petrushev, N | 1 |
| Mitrov, D | 1 |
| Kostovski, V | 1 |
| Mladenov, M | 1 |
| Al-Rasheed, N | 2 |
| Faddah, LM | 1 |
| Hasan, IH | 1 |
| Ali, HM | 1 |
| El Oraby, NF | 1 |
| Mohamed, MH | 1 |
| White, WB | 2 |
| Kloner, RA | 1 |
| Angiolillo, DJ | 1 |
| Davidson, MH | 1 |
| Wu, Y | 1 |
| Huang, X | 1 |
| Yang, M | 2 |
| Xu, J | 1 |
| Chen, Z | 1 |
| Yu, Z | 1 |
| Liu, J | 2 |
| Hirata, S | 1 |
| Kadowaki, D | 1 |
| Narita, Y | 1 |
| Hegazy, MGA | 1 |
| Emam, MA | 1 |
| Khattab, HI | 1 |
| Helal, NM | 1 |
| Dathe, K | 1 |
| Frank, J | 1 |
| Padberg, S | 1 |
| Hultzsch, S | 1 |
| Meixner, K | 1 |
| Beck, E | 1 |
| Meister, R | 1 |
| Schaefer, C | 1 |
| Blieden, M | 1 |
| Paramore, LC | 1 |
| Shah, D | 1 |
| Ben-Joseph, R | 1 |
| Wang, C | 1 |
| Wu, M | 1 |
| Arvapalli, R | 1 |
| Dai, X | 1 |
| Mahmood, M | 1 |
| Driscoll, H | 1 |
| Rice, KM | 1 |
| Blough, E | 1 |
| Dhibi, S | 1 |
| Mbarki, S | 1 |
| Elfeki, A | 1 |
| Hfaiedh, N | 1 |
| Ściskalska, M | 1 |
| Śliwińska-Mossoń, M | 1 |
| Podawacz, M | 1 |
| Sajewicz, W | 1 |
| Milnerowicz, H | 1 |
| Naguib, YM | 1 |
| Azmy, RM | 1 |
| Samaka, RM | 1 |
| Salem, MF | 1 |
| Roberts, E | 1 |
| Delgado Nunes, V | 1 |
| Buckner, S | 1 |
| Latchem, S | 1 |
| Constanti, M | 1 |
| Miller, P | 1 |
| Doherty, M | 1 |
| Zhang, W | 1 |
| Birrell, F | 1 |
| Porcheret, M | 1 |
| Dziedzic, K | 1 |
| Bernstein, I | 1 |
| Wise, E | 1 |
| Conaghan, PG | 1 |
| Wise, J | 1 |
| Bellei, E | 1 |
| Monari, E | 1 |
| Bergamini, S | 1 |
| Cuoghi, A | 1 |
| Tomasi, A | 1 |
| Guerzoni, S | 1 |
| Ciccarese, M | 1 |
| Pini, LA | 1 |
| Canayakin, D | 1 |
| Bayir, Y | 1 |
| Kilic Baygutalp, N | 1 |
| Sezen Karaoglan, E | 1 |
| Atmaca, HT | 1 |
| Kocak Ozgeris, FB | 1 |
| Keles, MS | 1 |
| Halici, Z | 1 |
| Adil, M | 1 |
| Kandhare, AD | 1 |
| Ghosh, P | 1 |
| Venkata, S | 1 |
| Raygude, KS | 1 |
| Bodhankar, SL | 1 |
| Wolenski, FS | 1 |
| Shah, P | 1 |
| Sano, T | 1 |
| Shinozawa, T | 1 |
| Bernard, H | 1 |
| Gallacher, MJ | 1 |
| Wyllie, SD | 1 |
| Varrone, G | 1 |
| Cicia, LA | 1 |
| Carsillo, ME | 1 |
| Fisher, CD | 1 |
| Ottinger, SE | 1 |
| Koenig, E | 1 |
| Kirby, PJ | 1 |
| Onaolapo, OJ | 1 |
| Adekola, MA | 1 |
| Azeez, TO | 1 |
| Salami, K | 1 |
| Onaolapo, AY | 1 |
| Reshi, MS | 1 |
| Shrivastava, S | 1 |
| Jaswal, A | 1 |
| Sinha, N | 1 |
| Uthra, C | 1 |
| Shukla, S | 1 |
| Ko, JW | 1 |
| Shin, JY | 1 |
| Kim, JW | 1 |
| Park, SH | 1 |
| Shin, NR | 1 |
| Lee, IC | 1 |
| Shin, IS | 1 |
| Moon, C | 1 |
| Kim, SH | 2 |
| Kim, JC | 1 |
| Jamshidzadeh, A | 1 |
| Baghban, M | 1 |
| Azarpira, N | 1 |
| Mohammadi Bardbori, A | 1 |
| Niknahad, H | 1 |
| Pakravan, N | 1 |
| Simpson, KJ | 1 |
| Waring, WS | 1 |
| Bates, CM | 1 |
| Bateman, DN | 1 |
| Ilbey, YO | 2 |
| Ozbek, E | 2 |
| Cekmen, M | 2 |
| Somay, A | 2 |
| Ozcan, L | 1 |
| Otünctemur, A | 1 |
| Simsek, A | 2 |
| Mete, F | 1 |
| Doi, K | 2 |
| Ishida, K | 2 |
| Ersoz, C | 1 |
| Bektas, F | 1 |
| Eken, C | 1 |
| Karadeniz, O | 1 |
| Goksu, E | 1 |
| Cubuk, M | 1 |
| Cete, Y | 1 |
| Kheradpezhouh, E | 1 |
| Panjehshahin, MR | 1 |
| Miri, R | 1 |
| Javidnia, K | 1 |
| Noorafshan, A | 1 |
| Monabati, A | 1 |
| Dehpour, AR | 1 |
| Molinas, SM | 1 |
| Rosso, M | 1 |
| Wayllace, NZ | 1 |
| Pagotto, MA | 1 |
| Pisani, GB | 1 |
| Monasterolo, LA | 2 |
| Trumper, L | 3 |
| Palani, S | 2 |
| Raja, S | 2 |
| Naresh, R | 1 |
| Kumar, BS | 2 |
| Demirbag, S | 1 |
| Uysal, B | 1 |
| Guven, A | 2 |
| Cayci, T | 2 |
| Ozler, M | 1 |
| Ozcan, A | 1 |
| Kaldirim, U | 1 |
| Surer, I | 1 |
| Korkmaz, A | 1 |
| Cakir, E | 1 |
| Akgul, OE | 1 |
| Aydin, I | 1 |
| Kurt, YG | 1 |
| Onguru, O | 1 |
| Aydin, FN | 1 |
| Agilli, M | 1 |
| Yaman, H | 1 |
| Ersoz, N | 1 |
| Bilgic, S | 1 |
| Turker, T | 1 |
| Bilgi, C | 1 |
| Erbil, KM | 1 |
| Zhao, YL | 1 |
| Zhou, GD | 1 |
| Yang, HB | 1 |
| Wang, JB | 1 |
| Shan, LM | 1 |
| Li, RS | 1 |
| Xiao, XH | 1 |
| Kumar, RP | 1 |
| Selvaraj, R | 1 |
| Roth, SH | 1 |
| Anderson, S | 1 |
| Parameshappa, B | 1 |
| Ali Basha, MS | 1 |
| Sen, S | 1 |
| Chakraborty, R | 1 |
| Kumar, GV | 1 |
| Sagar, GV | 1 |
| Sowmya, L | 1 |
| Raju, KK | 1 |
| Sesh Kumar, PK | 1 |
| Lakshmi, AV | 1 |
| Zhang, Y | 1 |
| Jia, Y | 1 |
| Yang, P | 1 |
| Tian, Y | 1 |
| Xiao, A | 1 |
| Wen, A | 1 |
| Kelkar, M | 1 |
| Cleves, MA | 1 |
| Foster, HR | 1 |
| Hogan, WR | 1 |
| James, LP | 1 |
| Martin, BC | 1 |
| Wong, F | 1 |
| Bagchi, D | 2 |
| Ray, SD | 2 |
| Bagchi, M | 1 |
| Preuss, HG | 1 |
| Stohs, SJ | 1 |
| Ahmed, MH | 1 |
| Ashton, N | 1 |
| Balment, RJ | 1 |
| Li, C | 1 |
| Saavedra, JE | 1 |
| Keefer, LK | 1 |
| Waalkes, MP | 1 |
| Lipworth, L | 1 |
| Friis, S | 1 |
| Mellemkjaer, L | 1 |
| Signorello, LB | 1 |
| Johnsen, SP | 1 |
| Nielsen, GL | 1 |
| McLaughlin, JK | 1 |
| Blot, WJ | 1 |
| Olsen, JH | 1 |
| Lorz, C | 2 |
| Justo, P | 2 |
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| Slitt, AL | 2 |
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| Cohen, SD | 7 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Synergistic Effect Of Parenteral Diclofenac And Paracetamol In The Pain Management Of Acute Limb Injuries[NCT04199572] | Phase 4 | 162 participants (Actual) | Interventional | 2022-10-16 | Completed | ||
| Intravenous Paracetamol or Morphine for the Treatment of Acute Flank Pain : a Randomized, Double Blind, Controlled Clinical Trial[NCT01318187] | Phase 4 | 73 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Treatment of Acetaminophen Toxicity With Intravenous vs Oral N-acetylcysteine: A Retrospective Review[NCT00725179] | 130 participants (Anticipated) | Observational | 2008-08-31 | Completed | |||
| A Full-Factorial, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose Efficacy and Safety Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen, and Naproxen Sodium in Postoperative Dental Pain[NCT05761574] | Phase 3 | 440 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | ||
| Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke[NCT04918719] | Phase 2 | 118 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
38 reviews available for acetaminophen and Kidney Diseases
| Article | Year |
|---|---|
Cardiorenal Safety of OTC Analgesics.
Topics: Acetaminophen; Analgesics; Drug Labeling; Heart Diseases; Humans; Ibuprofen; Kidney Diseases; Naprox | 2018 |
A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2014 |
Mechanisms of interaction of the N-acetyl-p-aminophenol metabolites in terms of nephrotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Epithelial Cells; Humans; Kidney; Kidne | 2015 |
Paracetamol: not as safe as we thought? A systematic literature review of observational studies.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Dose-Response Relationship, Drug; | 2016 |
Diabetes and hypertriglyceridemia modify the mode of acetaminophen-induced hepatotoxicity and nephrotoxicity in rats and mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Diabetes M | 2009 |
The NSAID dilemma: managing osteoarthritis in high-risk patients.
Topics: Acetaminophen; Administration, Oral; Adrenal Cortex Hormones; Aged; Analgesics, Non-Narcotic; Analge | 2011 |
Liver and kidney diseases.
Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G | 2002 |
[Paracetamol in the treatment of osteoarthritis pain].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg | 2003 |
[Tolerability of paracetamol].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Bias; Case-Control Studies; Chemical and Drug Induced Liver | 2003 |
[New molecular mechanisms of nephrotoxicity].
Topics: Acetaminophen; Apoptosis; bcl-X Protein; Caspase 8; Caspases; Cyclosporine; Cysteine Proteinase Inhi | 2004 |
Recent advances in postoperative pain therapy.
Topics: Acetaminophen; Acute Disease; Analgesia; Cyclooxygenase Inhibitors; Gastrointestinal Diseases; Human | 2005 |
A clinical and pharmacoeconomic justification for intravenous acetylcysteine: a US perspective.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Contrast Media; Humans; Injections, Intr | 2005 |
The use of NSAIDs in rheumatic disorders 2005: a global perspective.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Cyclooxyge | 2005 |
Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Black or African A | 2006 |
COX-2 selective inhibitors in the treatment of osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cycl | 2008 |
Management of chronic musculoskeletal pain in the elderly: opinions on oral medication use.
Topics: Acetaminophen; Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antipain; Chroni | 2008 |
Aspirin and renal disease.
Topics: Acetaminophen; Aspirin; Drug Synergism; Humans; Kidney Diseases; Time Factors | 1983 |
Nonprescription analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj | 1983 |
Chemically induced nephrotoxicity: role of metabolic activation.
Topics: Acetaminophen; Animals; Antifungal Agents; Antinematodal Agents; Biotransformation; Bromobenzenes; B | 1984 |
Paracetamol.
Topics: Acetaminophen; Acetylcysteine; Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Cystea | 1980 |
Mechanisms in the development of analgesic nephropathy.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Synergism; Humans; Ki | 1980 |
Environmental factors in renal disease.
Topics: Acetaminophen; Anti-Inflammatory Agents; Cadmium Poisoning; Cisplatin; Environmental Exposure; Gold; | 1981 |
Renal effects of over-the-counter analgesics.
Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Kid | 1995 |
[Paracetamol--kidney and urinary tract. A cause of analgetic nephropathy or cancer?].
Topics: Acetaminophen; Drug Utilization; Humans; Kidney; Kidney Diseases; Kidney Neoplasms; Scandinavian and | 1994 |
Nonnarcotic analgesics: prevalence and estimated economic impact of toxicities.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical | 1997 |
Ibuprofen, aspirin and acetaminophen toxicosis and treatment in dogs and cats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1998 |
[Analgesics and kidney].
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibito | 1998 |
Reduction of postembolization syndrome after ablation of renal angiomyolipoma.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Angiography; Angiomyolipoma; Catheter Ablation; Drug | 2002 |
Acetaminophen.
Topics: Acetaminophen; Analgesia; Animals; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; | 1977 |
[Tumors of the efferent parts of the urinary tract and abuse of analgesics].
Topics: Acetaminophen; Adult; Analgesics; Carcinoma, Squamous Cell; Choriocarcinoma; Female; Humans; Kidney | 1978 |
The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj | 1979 |
Drug-induced renal disease.
Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Angiotensin-Converting Enzyme Inhibitors; Anti-Infla | 1992 |
Paracetamol, nonsteroidal antiinflammatory drugs and nephrotoxicity.
Topics: Acetaminophen; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Humans; Kidney; Kidney Diseases | 1991 |
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen | 1986 |
Biochemical mechanisms of nephrotoxicity.
Topics: Acetaminophen; Aminoglycosides; Animals; Biotransformation; Bromobenzenes; Cephaloridine; Chloroform | 1985 |
Acute hepatic necrosis and fulminant hepatic failure.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Blood Coagulation Disorders; Brain Dise | 1973 |
Renal disorders in rheumatoid arthritis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Amyloidosis; Arthritis, Rheumatoid; Bacteriuria; Biopsy; End | 1971 |
Aspirin and the kidney.
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Humans; Kidney; Kidney Diseases; Kidney Papillary Nec | 1971 |
6 trials available for acetaminophen and Kidney Diseases
| Article | Year |
|---|---|
The Effects of Silymarin on Acetaminophen-Induced Acute Hepatic and Renal Toxicities in Domestic Pigeons (
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Bird Diseases; Chemic | 2020 |
Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial.
Topics: Acetaminophen; Adult; Analgesics; Colic; Emergency Service, Hospital; Female; Humans; Infusions, Int | 2009 |
Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial.
Topics: Acetaminophen; Adult; Analgesics; Colic; Emergency Service, Hospital; Female; Humans; Infusions, Int | 2009 |
Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial.
Topics: Acetaminophen; Adult; Analgesics; Colic; Emergency Service, Hospital; Female; Humans; Infusions, Int | 2009 |
Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial.
Topics: Acetaminophen; Adult; Analgesics; Colic; Emergency Service, Hospital; Female; Humans; Infusions, Int | 2009 |
[Selected biochemical parameters of urine in the evaluation of paracetamol nephrotoxicity].
Topics: Acetaminophen; Acetylglucosaminidase; Adolescent; Adult; beta 2-Microglobulin; Biomarkers; Dose-Resp | 2006 |
Renal function after short-term ibuprofen use in infants and children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Urea Nitroge | 1997 |
Acetaminophen.
Topics: Acetaminophen; Analgesia; Animals; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; | 1977 |
Analgesic use and chronic renal disease.
Topics: Acetaminophen; Adult; Aged; Analgesics; Arthritis; Aspirin; Chronic Disease; Dose-Response Relations | 1989 |
177 other studies available for acetaminophen and Kidney Diseases
| Article | Year |
|---|---|
Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Femal | 1980 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Biomarkers in neonates receiving potential nephrotoxic drugs.
Topics: Acetaminophen; Adult; Amikacin; Biomarkers; Cystatins; Female; Furosemide; Gentamicins; Hepatitis A | 2021 |
Acetaminophen-Induced Nephrotoxicity: Suppression of Apoptosis and Endoplasmic Reticulum Stress Using Boric Acid.
Topics: Acetaminophen; Acetylcysteine; Animals; Apoptosis; Boron; Endoplasmic Reticulum Stress; Kidney Disea | 2023 |
Tanshinone IIA prevents acetaminophen-induced nephrotoxicity through the activation of the Nrf2-Mrp2/4 pathway in mice.
Topics: Abietanes; Acetaminophen; Animals; Kidney Diseases; Mice; Mice, Inbred C57BL; Multidrug Resistance-A | 2022 |
Omega-3 fatty acids protect against acetaminophen-induced hepatic and renal toxicity in rats through HO-1-Nrf2-BACH1 pathway.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Basic-Leucine Zipper Transcription Factors; Cell N | 2020 |
Estrogen receptor agonists protect against acetaminophen-induced hepatorenal toxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2020 |
Predicting changes in renal metabolism after compound exposure with a genome-scale metabolic model.
Topics: Acetaminophen; Animals; Cells, Cultured; Databases, Genetic; Energy Metabolism; Epithelial Cells; Fe | 2021 |
Protective role of Chlorella vulgaris with Thiamine against Paracetamol induced toxic effects on haematological, biochemical, oxidative stress parameters and histopathological changes in Wistar rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cardiotoxicity; Chemical and Drug Induced Liver In | 2021 |
The impact of vitamin C on the relationship among inflammation, lipid peroxidation and platelet activation during analgesic nephropathy in rats.
Topics: Acetaminophen; Analgesics; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Cytokines; Dinoprost; I | 2017 |
Amelioration of panadol-induced nephrotoxicity via down-regulation of Bax/Bcl2 ratio with some antioxidants.
Topics: Acetaminophen; Animals; Antioxidants; bcl-2-Associated X Protein; Biological Products; Dose-Response | 2017 |
Ameliorative effect of berberine coated bio-active nanoparticles in acetaminophen induced hepato-renal damage in diabetic rats.
Topics: Acetaminophen; Animals; Antioxidants; Berberine; Diabetes Mellitus, Experimental; Drug Carriers; Kid | 2018 |
[Drug-induced kidney injury by non-steroidal anti-inflammatory drugs: Do COX-2 selective inhibitors and acetaminophen induce kidney injury?].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2016 |
Biological activity of Echinops spinosus on inhibition of paracetamol-induced renal inflammation.
Topics: Acetaminophen; Animals; Echinops Plant; Inflammation; Kidney; Kidney Diseases; Male; Plant Extracts; | 2019 |
Negligible risk of prenatal ductus arteriosus closure or fetal renal impairment after third-trimester paracetamol use: evaluation of the German Embryotox cohort.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Female; Humans; Infant, N | 2019 |
Acetaminophen attenuates obesity-related renal injury through ER-mediated stress mechanisms.
Topics: Acetaminophen; Activating Transcription Factor 4; Albuminuria; Analgesics, Non-Narcotic; Animals; Ap | 2014 |
Eucalyptus globulus extract protects upon acetaminophen-induced kidney damages in male rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Eucalyptus; Kidney Diseases; Male; Oxidative Stres | 2014 |
Pleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress in acetaminophen-induced hepato-renal injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biological | 2014 |
True risks of paracetamol may be underestimated, say researchers.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Dose-Response Relationship, Drug; | 2015 |
Validation of potential candidate biomarkers of drug-induced nephrotoxicity and allodynia in medication-overuse headache.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chronic Disea | 2015 |
Paracetamol-induced nephrotoxicity and oxidative stress in rats: the protective role of Nigella sativa.
Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Creatini | 2016 |
Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2016 |
Identification of microRNA biomarker candidates in urine and plasma from rats with kidney or liver damage.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cisplatin; Disease Model | 2017 |
l-Methionine and silymarin: A comparison of prophylactic protective capabilities in acetaminophen-induced injuries of the liver, kidney and cerebral cortex.
Topics: Acetaminophen; Animals; Antioxidants; Anxiety; Behavior, Animal; Biomarkers; Brain Diseases; Cerebra | 2017 |
Gold nanoparticles ameliorate acetaminophen induced hepato-renal injury in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Disease Mo | 2017 |
Protective effects of diallyl disulfide against acetaminophen-induced nephrotoxicity: A possible role of CYP2E1 and NF-κB.
Topics: Acetaminophen; Allyl Compounds; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspas | 2017 |
Effects of tomato extract on oxidative stress induced toxicity in different organs of rats.
Topics: Acetaminophen; Amiodarone; Analgesics, Non-Narcotic; Animals; Anti-Arrhythmia Agents; Chemical and D | 2008 |
Renal injury at first presentation as a predictor for poor outcome in severe paracetamol poisoning referred to a liver transplant unit.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cohort Studies; Creatinine; Databases, Factual; Fema | 2009 |
Melatonin prevents acetaminophen-induced nephrotoxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Kidney; Kidney Diseases; Male; Melatonin; Rats; Ra | 2009 |
Curcumin prevents oxidative renal damage induced by acetaminophen in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; | 2009 |
Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Biomarkers; Catalase; Curcumin; Drug Synergism; Glutathione | 2010 |
Heat shock protein 70 induction and its urinary excretion in a model of acetaminophen nephrotoxicity.
Topics: Acetaminophen; Acetylglucosaminidase; Analgesics, Non-Narcotic; Animals; Creatinine; Disease Models, | 2010 |
Evaluation of nephroprotective, diuretic, and antioxidant activities of plectranthus amboinicus on acetaminophen-induced nephrotoxic rats.
Topics: Acetaminophen; Animals; Kidney; Kidney Diseases; Male; Plant Extracts; Rats; Rats, Wistar | 2010 |
Effects of medical ozone therapy on acetaminophen-induced nephrotoxicity in rats.
Topics: Acetaminophen; Animals; Kidney; Kidney Diseases; Kidney Function Tests; Male; Oxidative Stress; Ozon | 2010 |
The association between neopterin and acetaminophen-induced nephrotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Kidney; Kidney Diseases; Male; Neopter | 2010 |
Rhein protects against acetaminophen-induced hepatic and renal toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anthraquinones; Antioxidants; Bilirubin; Chemical and | 2011 |
Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis.
Topics: Acetaminophen; Animals; Antioxidants; Creatine; Disease Models, Animal; Ethanol; Kidney Diseases; Ma | 2011 |
Acetaminophen-induced nephrotoxicity in rats: protective role of Cardiospermum halicacabum.
Topics: Acetaminophen; Alkanes; Analgesics, Non-Narcotic; Animals; Blood Urea Nitrogen; Kidney Diseases; Kid | 2012 |
The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl(4)-model rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arylsulfotransferase; Carbon Tetrachloride Poisoni | 2012 |
Acute and chronic acetaminophen use and renal disease: a case-control study using pharmacy and medical claims.
Topics: Acetaminophen; Case-Control Studies; Female; Humans; Insurance, Health, Reimbursement; Kidney Diseas | 2012 |
Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Analgesics, Non-Narcotic; Ani | 2002 |
Renal function in a rat model of analgesic nephropathy: effect of chloroquine.
Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Chloroquine; Dise | 2003 |
The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced nephrotoxicity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Urea Nitrogen; Dose-Response Relationship, D | 2003 |
A population-based cohort study of mortality among adults prescribed paracetamol in Denmark.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Cardiovascular Diseases; Cause of Death; Cerebrovascu | 2003 |
Paracetamol-induced renal tubular injury: a role for ER stress.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Caspase 12; Caspases; Cell Death; Cells | 2004 |
Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 2: toxicological evaluation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animal Testing Alternatives; Animals; Cell Culture Techniqu | 2004 |
The shark bile salt 5 beta-scymnol abates acetaminophen toxicity, but not covalent binding.
Topics: Acetaminophen; Animals; Antioxidants; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; | 2004 |
Standard of care may not protect against acetaminophen-induced nephrotoxicity.
Topics: Acetaminophen; Animals; Antidotes; Delivery of Health Care; Disease Models, Animal; Kidney Diseases; | 2004 |
Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity II. Possible involvement of the gamma-glutamyl cycle.
Topics: Acetaminophen; Animals; Cell Membrane; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; D | 2005 |
Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity in CD-1 mice: I. Enhancement of acetaminophen nephrotoxicity by acetaminophen-cysteine.
Topics: Acetaminophen; Animals; Cysteine; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Inj | 2005 |
Vitamin C may be beneficial in the prevention of paracetamol-induced renal damage.
Topics: Acetaminophen; Animals; Antioxidants; Ascorbic Acid; Creatinine; Dose-Response Relationship, Drug; F | 2005 |
Effect of ribose cysteine pretreatment on hepatic and renal acetaminophen metabolite formation and glutathione depletion.
Topics: Acetaminophen; Animals; Blood Urea Nitrogen; Buthionine Sulfoximine; Chemical and Drug Induced Liver | 2005 |
Parenteral iron therapy: a single institution's experience over a 5-year period.
Topics: Acetaminophen; Anemia, Iron-Deficiency; Diphenhydramine; Female; Ferric Compounds; Ferric Oxide, Sac | 2005 |
Propylthiouracil attenuates acetaminophen-induced renal damage in the rat.
Topics: Acetaminophen; Animals; Creatinine; Dose-Response Relationship, Drug; Kidney; Kidney Diseases; Lipid | 2005 |
Mega dose of vitamin C augments the nephrotoxicity of paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Ascorbic Acid; Drug Interactions; Ki | 2005 |
Erdosteine against acetaminophen induced renal toxicity.
Topics: Acetaminophen; Animals; Drug Evaluation, Preclinical; Female; Kidney; Kidney Cortex; Kidney Diseases | 2006 |
Evaluation of renal enzymuria and cellular excretion as an marker of acute nephrotoxicity due to an overdose of paracetamol in Wistar rats.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Anim | 2006 |
In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney.
Topics: Acetaminophen; Aristolochic Acids; Cadmium Chloride; Cell Line; Cell Survival; Chemical and Drug Ind | 2007 |
Role of nitric oxide and reduced glutathione in the protective effects of aminoguanidine, gadolinium chloride and oleanolic acid against acetaminophen-induced hepatic and renal damage.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Nar | 2007 |
Analgesic nephropathy.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Aspirin; Drug Combinations; Headache; Humans; Kidney | 2007 |
The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidan | 2008 |
Association of analgesic use with prevalence of albuminuria and reduced GFR in US adults.
Topics: Acetaminophen; Adult; Aged; Albuminuria; Analgesics; Aspirin; Cross-Sectional Studies; Female; Glome | 2008 |
Propolis reverses acetaminophen induced acute hepatorenal alterations: a biochemical and histopathological approach.
Topics: Acetaminophen; Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Antioxida | 2008 |
Beta 2-microglobulin and other proteins as parameter for tubular function.
Topics: Acetaminophen; Amino Acid Sequence; Aspirin; beta 2-Microglobulin; Beta-Globulins; Female; Graft Rej | 1981 |
Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine.
Topics: Acetaminophen; Adult; Alcohols; Animals; Chemical Phenomena; Chemistry; Diabetes Mellitus; Fasting; | 1984 |
Clinical assessment of the renal toxicity of antirheumatic drugs.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dinoprostone | 1984 |
Enzyme systems involved in the formation of reactive metabolites in the renal medulla: cooxidation via prostaglandin H synthase.
Topics: Acetaminophen; Animals; Benzidines; Biotransformation; Kidney Diseases; Kidney Medulla; Mixed Functi | 1984 |
Analgesic nephropathy associated with paracetamol.
Topics: Acetaminophen; Adult; Aged; Female; Humans; Kidney Diseases; Kidney Failure, Chronic; Kidney Functio | 1984 |
Nephrotoxicity of mild analgesics in the Gunn strain of rat.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Glucuronosyltransferase; Kidney Diseases; Kidney Medull | 1980 |
Evaluation of an enzymic procedure for the measurement of acetaminophen.
Topics: Acetaminophen; Amidohydrolases; Aminophenols; Chromatography, High Pressure Liquid; Colorimetry; Eme | 1983 |
Epidemiologic study of abuse of analgesics containing phenacetin. Renal morbidity and mortality (1968-1979).
Topics: Acetaminophen; Adult; Analgesics; Bacteriuria; Creatinine; Female; Humans; Kidney Diseases; Longitud | 1983 |
A new reproducible experimental model of analgesic nephropathy.
Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Aspirin; Disease Models, Animal; Female; Kidney; Kid | 1983 |
Acetaminophen nephrotoxicity in the rat. I. Strain differences in nephrotoxicity and metabolism.
Topics: Acetaminophen; Animals; Biotransformation; Drug Resistance; In Vitro Techniques; Kidney; Kidney Dise | 1983 |
Acetaminophen nephrotoxicity in the rat. II. Strain differences in nephrotoxicity and metabolism of p-aminophenol, a metabolite of acetaminophen.
Topics: Acetaminophen; Aminophenols; Animals; Drug Resistance; In Vitro Techniques; Kidney Cortex; Kidney Di | 1983 |
Analgesic nephropathy in 1981: which drug is responsible?
Topics: Acetaminophen; Analgesics; Humans; Kidney; Kidney Diseases; Nephritis, Interstitial; Phenacetin | 1982 |
Epidemiology of analgesic nephropathy in Belgium.
Topics: Acetaminophen; Analgesics; Antipyrine; Aspirin; Belgium; Caffeine; Drug Combinations; Humans; Kidney | 1982 |
The influence of metabolic variation on analgesic nephrotoxicity. Experiments with the Gunn rat.
Topics: Acetaminophen; Aminophenols; Aminosalicylic Acids; Analgesics; Animals; Aspirin; Genetic Carrier Scr | 1982 |
Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the fischer 344 rat.
Topics: Acetaminophen; Alanine Transaminase; Aminophenols; Animals; Blood Urea Nitrogen; Isomerism; Kidney D | 1982 |
Acetaminophen as an aspirin substitute: is it safer?
Topics: Acetaminophen; Aspirin; Biotransformation; Cardiomyopathies; Chemical and Drug Induced Liver Injury; | 1980 |
Acetaminophen nephrotoxicity: studies on renal acetylation and deacetylation.
Topics: Acetaminophen; Acetylation; Acetyltransferases; Aminophenols; Animals; In Vitro Techniques; Kidney; | 1981 |
Experimental paracetamol nephropathy and pyelonephritis in rats.
Topics: Acetaminophen; Animals; Female; Kidney Diseases; Kidney Papillary Necrosis; Pyelonephritis; Rats; Ra | 1981 |
Effect of analgesic nephropathy in women on the metabolism and excretion of 14C-acetaminophen.
Topics: Acetaminophen; Adult; Analgesics; Creatinine; Female; Humans; Kidney Diseases; Kinetics; Middle Aged | 1980 |
[H. U. Zollinger: 25 years of phenacetin abuse].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Legislation, Drug; P | 1980 |
Contribution of oxidation and deacetylation to the bioactivation of acetaminophen in vitro in liver and kidney from male and female Sprague-Dawley rats.
Topics: Acetaminophen; Animals; Biotransformation; Carbon Radioisotopes; Female; Kidney; Kidney Diseases; Li | 1995 |
Retinol binding proteinuria and phosphaturia: markers of paracetamol-induced nephrotoxicity.
Topics: Acetaminophen; Adult; Biomarkers; Creatinine; Drug Overdose; Female; Fluorescence Polarization; Huma | 1994 |
Analgesics and the kidney: summary and recommendations to the Scientific Advisory Board of the National Kidney Foundation from an Ad Hoc Committee of the National Kidney Foundation.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Kidney Diseases | 1996 |
Evaluation of an enzyme-immunometric assay for serum alpha-glutathione S-transferase.
Topics: Acetaminophen; Alkaline Phosphatase; Analgesics, Non-Narcotic; Analysis of Variance; Arthritis, Rheu | 1995 |
Over-the-counter analgesics and kidney disease.
Topics: Acetaminophen; Analgesics; Aspirin; Drug Combinations; Headache; Humans; Kidney Diseases; Nonprescri | 1996 |
Analgesic nephropathy. Proceedings of a symposium. June 1995.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1996 |
Is activation of lysosomal enzymes responsible for paracetamol-induced hepatotoxicity and nephrotoxicity?
Topics: 4-Nitrophenylphosphatase; Acetaminophen; Amino Acids; Analgesics, Non-Narcotic; Animals; Cathepsin D | 1996 |
Sex- and age-dependent acetaminophen hepato- and nephrotoxicity in Sprague-Dawley rats: role of tissue accumulation, nonprotein sulfhydryl depletion, and covalent binding.
Topics: Acetaminophen; Age Factors; Animals; Chemical and Drug Induced Liver Injury; Female; Kidney; Kidney | 1996 |
Studies on the chronic oral toxicity of an analgesic drug combination consisting of acetylsalicylic acid, paracetamol and caffeine in rats including an electron microscopical evaluation of kidneys.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Blood Cell Count; Body Weight; Caffeine; Central Nervou | 1996 |
Clinical consequences of nonnarcotic analgesic use.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
Commentary on the National Kidney Foundation position paper on analgesics and the kidney.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; C | 1996 |
Analgesics and the kidney: recommendations of the National Kidney Foundation for the use of analgesics.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 1996 |
Effects of fructose-induced hypertriglyceridemia on hepatorenal toxicity of acetaminophen in rats: role of pharmacokinetics and metabolism of acetaminophen.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dose | 1997 |
The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats.
Topics: Acetaminophen; Acetylation; Analgesics, Non-Narcotic; Animals; Blood Urea Nitrogen; Female; Glutathi | 1997 |
Probenecid protects against In vivo acetaminophen-induced nephrotoxicity in male Wistar rats.
Topics: Acetaminophen; Acute Disease; Animals; Biological Transport; Creatinine; Diuresis; Glomerular Filtra | 1998 |
Analgesic nephropathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Drug Combinations; Drug Interactions; Hu | 1998 |
Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells.
Topics: Acetaminophen; Animals; Cell Division; Cells, Cultured; Chlorocebus aethiops; Cisplatin; DNA; Kidney | 1999 |
Acute effects of acetaminophen on renal function and urinary excretion of some proteins and enzymes in patients with kidney disease.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Enzymes; Glomerular Filtration Rate; Humans; | 1999 |
[Does TNF-alpha contribute to liver disease physiopathology?].
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2000 |
In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Animals; Antioxidants; Apopto | 2000 |
[Liver and renal tolerance to paracetamol: 3 g or 4 g per day?].
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Arthritis, Rheumatoid; Chemical and Drug Induced Live | 2001 |
Pain medicine. The dangers of acetaminophen.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; D | 2001 |
Nephrotoxicity after acute severe acetaminophen poisoning in adolescents.
Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics, Non-Narcotic; Child; Female; Humans; Kidney Di | 2001 |
Use of albumin dialysis in the treatment of hepatic and renal dysfunction due to paracetamol intoxication.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Humans; Kidn | 2002 |
Concomitant overdosing of other drugs in patients with paracetamol poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Dr | 2002 |
Acetaminophen, aspirin, and renal failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; K | 2002 |
Effects of "Chinese yam" on hepato-nephrotoxicity of acetaminophen in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dioscorea; | 2002 |
Relation between regular intake of phenacetin-containing analgesics and laboratory evidence for urorenal disorders in a working female population of Switzerland.
Topics: Acetaminophen; Adult; Age Factors; Bacteriuria; Creatinine; Female; Hematuria; Humans; Kidney Diseas | 1975 |
Salicylate-induced enzymuria: comparison with other anti-inflammatory agents.
Topics: Acetaminophen; Acetylglucosaminidase; Adult; Anti-Inflammatory Agents; Aspirin; Gold; Hexosaminidase | 1978 |
Analgesic nephropathy. Epidemiological studies and pharmacological investigations.
Topics: Acetaminophen; Adult; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Humans; Kidney | 1979 |
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cyst | 1979 |
[Demonstration of phenacetin].
Topics: Acetaminophen; Humans; Kidney Diseases; Methods; Phenacetin | 1978 |
Nephropathies due to analgesics.
Topics: Acetaminophen; Analgesics; Humans; Kidney; Kidney Diseases; Kidney Medulla; Phenacetin; Salicylates | 1978 |
Liver and kidney damage induced by N-hydroxyparacetamol.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Stability; Glutathione; Hydroxy | 1978 |
Analgesic-associated nephropathy in the U.S.A.: epidemiologic, clinical and pathogenetic features.
Topics: Acetaminophen; Adult; Aged; Analgesics; Animals; Aspirin; Creatinine; Drug Combinations; Female; Fol | 1978 |
Acetaminophen overdoses at a county hospital: a year's experience.
Topics: Acetaminophen; Acidosis; Adult; Amylases; Chemical and Drug Induced Liver Injury; Female; Hospitals, | 1978 |
Molecular basis for several drug-induced nephropathies.
Topics: Acetaminophen; Analgesics; Animals; Carbon Tetrachloride Poisoning; Cephaloridine; Chloroform; Cytoc | 1977 |
[Paracetamol --a harmless analgesic?].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Liver; Nonprescripti | 1977 |
[Kidney damage following paracetamol?].
Topics: Acetaminophen; Humans; Kidney Diseases; Time Factors | 1977 |
Analgesic nephropathy: renal distribution of acetaminophen and its conjugates.
Topics: Acetaminophen; Animals; Dogs; Female; Inulin; Kidney Cortex; Kidney Diseases; Urination | 1976 |
Analgesic nephropathy.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Co | 1976 |
Diseases causing end-stage renal failure in New South Wales.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Australia; Caffeine; Codeine; Cystoscopy; Female; Glomeru | 1975 |
Progress in hepatology. Metabolic activation of drugs to toxic substances.
Topics: Acetaminophen; Animals; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Chemical Pheno | 1975 |
Acetaminophen nephrotoxicity in male Wistar rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Glucose; Glutathione; Kidney; Kidney Diseases; Kidney | 1992 |
Acetaminophen induced pancreatitis.
Topics: Acetaminophen; Acute Disease; Adult; Ascites; Charcoal; Female; Humans; Ipecac; Kidney Diseases; Liv | 1991 |
Nephrotoxicity of paracetamol in the rat--mechanistic and therapeutic aspects.
Topics: Acetaminophen; Acetylcysteine; Acetylglucosaminidase; Animals; Antidotes; Ditiocarb; gamma-Glutamylt | 1991 |
Nephrotoxicity of 4-aminophenol glutathione conjugate.
Topics: Acetaminophen; Aminophenols; Animals; Glutathione; Kidney; Kidney Diseases; Liver; Male; Rats; Rats, | 1991 |
Analgesic nephropathy in Fischer 344 rats: comparative effects of chronic treatment with either aspirin or paracetamol.
Topics: Acetaminophen; Animals; Aspirin; Female; Incidence; Kidney Concentrating Ability; Kidney Diseases; K | 1991 |
[Paracetamol in therapeutic dosages can cause severe hepatic and renal damage in alcoholics].
Topics: Acetaminophen; Adult; Aged; Alcoholism; Chemical and Drug Induced Liver Injury; Female; Humans; Kidn | 1991 |
The risks of phenacetin use.
Topics: Acetaminophen; Child; Cohort Studies; Female; Follow-Up Studies; Humans; Kidney Diseases; Phenacetin | 1991 |
Evidence against deacetylation and for cytochrome P450-mediated activation in acetaminophen-induced nephrotoxicity in the CD-1 mouse.
Topics: Acetaminophen; Acetylation; Aminophenols; Animals; Blood Urea Nitrogen; Cytochrome P-450 Enzyme Inhi | 1991 |
Tell your kidneys to take a powder.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Humans; Kidney Diseases; Nonprescription Dru | 1991 |
Fractional excretion of beta-2-microglobulin in the urine of patients with normal or reduced renal function and hepatic coma.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Aged; beta 2-Microglobulin; Diagnosis, Differential; Fema | 1991 |
[Epidemiological studies of the frequency of the abuse of analgesics].
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Capillaries; Child; Child, Preschool; Fem | 1990 |
Ibuprofen-associated renal impairment in a large general internal medicine practice.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Age Factors; Aged; Analysis of Variance; Fema | 1990 |
Intrinsic susceptibility of the kidney to acetaminophen toxicity in middle-aged rats.
Topics: Acetaminophen; Aging; Animals; Glutathione; Kidney; Kidney Diseases; Male; p-Aminohippuric Acid; Rat | 1990 |
Experimental analgesic nephropathy: changes in renal structure and urinary concentrating ability in Fischer 344 rats given continuous low doses of aspirin and paracetamol.
Topics: Acetaminophen; Animals; Aspirin; Body Weight; Disease Models, Animal; Female; Kidney Concentrating A | 1990 |
Strain differences in acetaminophen nephrotoxicity in rats: role of pharmacokinetics.
Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Half-Life; Kidney Cortex; Kidney Diseases; | 1989 |
Analgesic use and chronic renal disease.
Topics: Acetaminophen; Analgesics; Aspirin; Chronic Disease; Data Collection; Humans; Kidney Diseases; Phena | 1989 |
Progression of renal failure in analgesic-associated nephropathy.
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Creatinine; Female; Humans; Kidney; Kidney Diseases | 1989 |
Colchicine toxicity: a case report.
Topics: Acetaminophen; Alcoholic Intoxication; Cardiovascular System; Colchicine; Digestive System; Hematopo | 1989 |
Analgesic nephropathy in West Germany.
Topics: Acetaminophen; Drug Therapy, Combination; Female; Germany, West; Humans; Kidney Diseases; Kidney Fai | 1986 |
Paracetamol: a cause for analgesic nephropathy and end-stage renal disease.
Topics: Acetaminophen; Adult; Aged; Calcinosis; Female; Humans; Kidney Diseases; Kidney Failure, Chronic; Ma | 1988 |
Potentiation of cadmium nephrotoxicity by acetaminophen.
Topics: Acetaminophen; Acetylglucosaminidase; Albuminuria; Animals; beta 2-Microglobulin; Cadmium; Drug Syne | 1988 |
Characteristics and clinical course of hemodialysis patients with analgesic-associated nephropathy.
Topics: Acetaminophen; Adaptation, Psychological; Age Factors; Female; Humans; Kidney Diseases; Male; Middle | 1988 |
Paracetamol medication and alcohol abuse: a dangerous combination for the liver and the kidney.
Topics: Acetaminophen; Adolescent; Adult; Alcoholism; Aspartate Aminotransferases; Chemical and Drug Induced | 1987 |
Further evidence of analgesic nephropathy in Malaysia.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; | 1986 |
Hemorrhagic pancreatitis associated with acetaminophen overdose.
Topics: Abdomen, Acute; Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Hemorrhage; Humans; Ki | 1986 |
The development of acetaminophen-induced nephrotoxicity in male Fischer 344 rats of different ages.
Topics: Acetaminophen; Aging; Animals; Blood Urea Nitrogen; Glomerulonephritis; Kidney Diseases; Kidney Tubu | 1986 |
Acetaminophen nephrotoxicity in the rat: quantitation of renal metabolic activation in vivo.
Topics: Acetaminophen; Amidohydrolases; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Kidney; | 1985 |
Iatrogenic drug toxicity.
Topics: Acetaminophen; Age Factors; Amphotericin B; Chemical and Drug Induced Liver Injury; Drug Interaction | 1985 |
Haemodialysis in paracetamol self-poisoning.
Topics: Acetaminophen; Adult; Autoanalysis; Chemical and Drug Induced Liver Injury; Female; Half-Life; Human | 1972 |
Treatment of acute paracetamol poisoning.
Topics: Acetaminophen; Adult; Blood Protein Disorders; Brain Edema; Chemical and Drug Induced Liver Injury; | 1968 |
Phenacetin.
Topics: Acetaminophen; Antipyrine; Denmark; Humans; Kidney Diseases; Kidney Neoplasms; Kidney Papillary Necr | 1969 |
[Kidney toxicity of analgesics].
Topics: Acetaminophen; Administration, Oral; Aspirin; Humans; Kidney Diseases; Long-Term Care; Phenacetin | 1973 |
Lysozymuria and acute disorders of renal function.
Topics: Acetaminophen; Acute Disease; Aspirin; Electroshock; Glomerulonephritis; Heart Failure; Humans; Hypo | 1973 |
Renal tubular reabsorption of acetaminophen after vasopressin administration in man.
Topics: Acetaminophen; Creatinine; Glomerular Filtration Rate; Humans; Kidney Diseases; Kidney Tubules; Vaso | 1973 |
Acute acetaminophen poisoning.
Topics: Acetaminophen; Bilirubin; Blood Coagulation Disorders; Cardiomyopathies; Diuresis; Humans; Hypoglyce | 1973 |
[Risks in long-term treatment with analgesics].
Topics: Acetaminophen; Analgesics; Antipyrine; Aspirin; Caffeine; Diuresis; Drug Combinations; Humans; Kidne | 1973 |
Analgesic nephropathy associated with paracetamol.
Topics: Acetaminophen; Codeine; Female; Headache; Humans; Kidney Diseases; Middle Aged; Nausea; Phenacetin; | 1973 |
Frequency and type of renal and electrolyte disorders in fulminant hepatic failure.
Topics: Acetaminophen; Acute Kidney Injury; Blood Glucose; Chemical and Drug Induced Liver Injury; Creatinin | 1974 |
Aspirin and the kidney. New Zealand Rheumatism Association Study.
Topics: Acetaminophen; Adult; Arthritis, Rheumatoid; Aspirin; Caffeine; Codeine; Drug Synergism; Female; Hum | 1974 |
Editorial: Choice of a mild analgesic.
Topics: Acetaminophen; Aspirin; Drug Combinations; Humans; Kidney Diseases; Phenacetin; Substance-Related Di | 1974 |
Effect of chronic administration of analgesics on resistance to experimental infection of the urinary tract in rats.
Topics: Acetaminophen; Animals; Aspirin; Bacteriuria; Escherichia coli Infections; Female; Foreign Bodies; K | 1968 |
Acetaminophen, valadol, and analgesic renal injury.
Topics: Acetaminophen; Analgesics; Aspirin; Humans; Kidney Diseases; Kidney Papillary Necrosis; Nephritis, I | 1971 |
["Phenacetin-kidney" or "analgetic-nephropathy"].
Topics: Acetaminophen; Aspirin; Humans; Kidney Diseases; Phenacetin | 1971 |
[The hazards of phenacetin and other analgesics].
Topics: Acetaminophen; Analgesics; Humans; Kidney Diseases; Phenacetin; Self Medication; Substance-Related D | 1969 |
[New aspects on the question of phenacetin nephrotoxicity].
Topics: Acetaminophen; Aniline Compounds; Animals; Humans; Kidney; Kidney Diseases; Phenacetin; Rats | 1969 |
Phenacetin nephropathy.
Topics: Acetaminophen; Adult; Humans; Kidney Diseases; Male; Middle Aged; Phenacetin | 1970 |
Phenacetin nephropathy, with particular reference to the effect of surgery.
Topics: Acetaminophen; Adult; Creatinine; England; Female; Hematuria; Humans; Hypertension, Renal; Kidney Di | 1970 |
Phenacetin nephropathy.
Topics: Acetaminophen; Animals; Aspirin; Caffeine; Humans; Kidney Diseases; Phenacetin; Rats | 1970 |
Paracetamol and renal damage.
Topics: Acetaminophen; Aged; Bacteriuria; Bicarbonates; Creatinine; Female; Hemoglobinometry; Humans; Kidney | 1971 |
[Detection and excretion of N-acetyl-p-aminophenol in relation to kidney function after phenacetin ingestion].
Topics: Acetaminophen; Creatinine; Glomerular Filtration Rate; Humans; Kidney Diseases; Metabolic Clearance | 1967 |
Hepatic and renal damage with paractamol overdosage.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Liver; Liver Disease | 1968 |