Page last updated: 2024-10-22

acetaminophen and Interstitial Nephritis

acetaminophen has been researched along with Interstitial Nephritis in 32 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
"We report a case of magnesium deficiency associated with acetaminophen abuse."3.68Renal magnesium wasting associated with acetaminophen abuse. ( Nortman, D; Tuso, PJ, 1992)
"Both phenacetin and paracetamol produce acute centrilobular liver necrosis in the homozygous Gunn rat."3.66Hepatotoxicity of phenacetin and paracetamol in the Gunn rat. ( Calder, IC; Hart, SJ; Smail, MC; Tange, JD, 1981)
"Analgesic nephropathy is part of a wider clinical syndrome associated with the abuse of APC compounds, that is, a minimum total intake of 2 kg of aspirin or phenacetin."3.65Analgesic nephropathy. ( Nanra, RS, 1976)
"Fluid and electrolyte disturbances, acute renal failure, and acute interstitial nephritis also occur predominantly with NSAIDs."2.39Renal effects of over-the-counter analgesics. ( Whelton, A, 1995)
"Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose."1.35Acetaminophen toxicity with concomitant use of carbamazepine. ( Ahmed, SN; Heino, A; Jickling, G, 2009)
" In contrast to acute renal insufficiency that may already occur after a single NSAID dose, analgesic nephropathy is a disease caused by long-term intake of NSAID compound analgesics and predominantly affects the middle and old age."1.33[Chronic interstitial nephritis in an 18-year-old due to intake of a compound analgesic]. ( Janssen, U; Jochum, E, 2006)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199017 (53.13)18.7374
1990's8 (25.00)18.2507
2000's4 (12.50)29.6817
2010's2 (6.25)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Higashi, Y1
Baba, N1
Yoshimine, H1
Sakaguchi, I1
Kanekura, T1
Wang, C1
Blough, ER1
Arvapalli, R1
Dai, X1
Paturi, S1
Manne, N1
Addagarla, H1
Triest, WE1
Olajide, O1
Wu, M1
Jickling, G1
Heino, A1
Ahmed, SN1
Fruchter, LL1
Alexopoulou, I1
Lau, KK1
Chow, KM1
Szeto, CC1
Li, P1
Lai, FM1
ANGERVALL, L3
LEHMANN, L3
LINCOLN, K3
Ozçakar, ZB1
Yüksel, S1
Ensari, A1
Ekim, M1
Yalçinkaya, F1
Jochum, E1
Janssen, U1
Pusey, CD1
Saltissi, D1
Bloodworth, L1
Rainford, DJ1
Christie, JL1
Offerhaus, L1
Goldberg, M3
Calder, IC1
Hart, SJ1
Smail, MC1
Tange, JD1
Zollinger, HU1
Kleinknecht, D2
Whelton, A1
Kantachuvesiri, S1
Kaojarern, S1
Kitayaporn, D1
Phanichphant, S1
Sumethkul, V1
Wananukul, W1
Pongskul, C1
Arkaravichien, W1
Jankriengkri, S1
Chanchairujira, T1
Trinn, C2
Szöke, B1
Tóth, T2
Nagy, J2
Szp6e, B1
Brasch, H1
Murray, TG1
Nanra, RS1
Murray, T1
Tuso, PJ1
Nortman, D1
Mathew, TH1
Gallego, N1
Teruel, JL1
Mampaso, F1
Gonzalo, A1
Ortuño, J1
Landais, P1
Goldfarb, B1
Segasothy, M1
Muhaya, HM1
Musa, A1
Rajagopalan, K1
Lim, KJ1
Fatimah, Y1
Kamal, A1
Ahmad, KS1
Burry, HC1
Wigley, RD1
Kincaid-Smith, P1

Reviews

6 reviews available for acetaminophen and Interstitial Nephritis

ArticleYear
Interstitial nephritis, the nephrotic syndrome, and chronic renal failure secondary to nonsteroidal anti-inflammatory drugs.
    Seminars in nephrology, 1995, Volume: 15, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Humans; Kidney Failure, C

1995
Renal effects of over-the-counter analgesics.
    Journal of clinical pharmacology, 1995, Volume: 35, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Kid

1995
Analgesic abuse and renal disease.
    Annual review of medicine, 1975, Volume: 26

    Topics: Acetaminophen; Adult; Aged; Animals; Aspirin; Creatinine; Drug Combinations; Humans; Inactivation, M

1975
Drug-induced renal disease.
    The Medical journal of Australia, 1992, May-18, Volume: 156, Issue:10

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Angiotensin-Converting Enzyme Inhibitors; Anti-Infla

1992
Renal disorders in rheumatoid arthritis.
    Rheumatology and physical medicine, 1971, Volume: 11, Issue:1

    Topics: Acetaminophen; Adrenal Cortex Hormones; Amyloidosis; Arthritis, Rheumatoid; Bacteriuria; Biopsy; End

1971
Aspirin and the kidney.
    The New Zealand medical journal, 1971, Volume: 74, Issue:474

    Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Humans; Kidney; Kidney Diseases; Kidney Papillary Nec

1971

Other Studies

26 other studies available for acetaminophen and Interstitial Nephritis

ArticleYear
Late-onset interstitial nephritis in a patient with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms.
    The Journal of dermatology, 2020, Volume: 47, Issue:2

    Topics: Acetaminophen; Biopsy; Carbocysteine; Clarithromycin; Creatinine; Drug Hypersensitivity Syndrome; Dr

2020
Metabolic syndrome-induced tubulointerstitial injury: role of oxidative stress and preventive effects of acetaminophen.
    Free radical biology & medicine, 2013, Volume: 65

    Topics: Acetaminophen; Actins; Analgesics, Non-Narcotic; Animals; Apoptosis; bcl-2-Associated X Protein; Cas

2013
Acetaminophen toxicity with concomitant use of carbamazepine.
    Epileptic disorders : international epilepsy journal with videotape, 2009, Volume: 11, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anticonvulsants; Back Pain; Carbamazepine; Chemical

2009
Acute interstitial nephritis with acetaminophen and alcohol intoxication.
    Italian journal of pediatrics, 2011, Apr-15, Volume: 37

    Topics: Acetaminophen; Acute Disease; Adolescent; Alcoholic Intoxication; Analgesics, Non-Narcotic; Ethanol;

2011
Acute interstitial nephritis and COX-2 inhibition.
    Hospital medicine (London, England : 1998), 2003, Volume: 64, Issue:7

    Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase

2003
Induction of interstitial nephritis in rats fed phenacetin and NAPA (N-acetyl-p-aminophenol).
    Acta pathologica et microbiologica Scandinavica, 1962, Volume: 54

    Topics: Acetaminophen; Animals; Nephritis; Nephritis, Interstitial; Phenacetin; Rats

1962
On action of Napa (n-acetyl-p-aminophenol) on the induction of interstitial nephritis in rats.
    Acta pathologica et microbiologica Scandinavica, 1962, Volume: 54

    Topics: Acetaminophen; Acetanilides; Animals; Nephritis, Interstitial; Phenacetin; Rats

1962
On the effect of phenacetin and Napa (n-acetyl-p-aminophenol) on the development of bacterial interstitial nephritis in the rat.
    Acta pathologica et microbiologica Scandinavica. Supplement, 1962, Volume: Suppl 154

    Topics: Acetaminophen; Animals; Nephritis; Nephritis, Interstitial; Phenacetin; Rats

1962
Acute renal failure in a patient with familial Mediterranean fever.
    Rheumatology international, 2007, Volume: 27, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Amyloidosis; Anti-Inflammatory Agents, Non-Steroidal

2007
[Chronic interstitial nephritis in an 18-year-old due to intake of a compound analgesic].
    Medizinische Klinik (Munich, Germany : 1983), 2006, Oct-15, Volume: 101, Issue:10

    Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Caffeine; Creat

2006
Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy.
    The Quarterly journal of medicine, 1983,Spring, Volume: 52, Issue:206

    Topics: Acetaminophen; Acute Disease; Adult; Ampicillin; Anti-Infective Agents, Urinary; Bendroflumethiazide

1983
[How safe is paracetamol?].
    Nederlands tijdschrift voor geneeskunde, 1983, Jun-11, Volume: 127, Issue:24

    Topics: Acetaminophen; Animals; Drug Combinations; Humans; Kidney Papillary Necrosis; Nephritis, Interstitia

1983
Analgesic nephropathy in 1981: which drug is responsible?
    JAMA, 1982, Jan-01, Volume: 247, Issue:1

    Topics: Acetaminophen; Analgesics; Humans; Kidney; Kidney Diseases; Nephritis, Interstitial; Phenacetin

1982
Hepatotoxicity of phenacetin and paracetamol in the Gunn rat.
    Pathology, 1981, Volume: 13, Issue:4

    Topics: Acetaminophen; Animals; Female; Liver; Necrosis; Nephritis, Interstitial; Phenacetin; Rats; Rats, Gu

1981
[25 years of phenacetin abuse].
    Schweizerische medizinische Wochenschrift, 1980, Jan-28, Volume: 110, Issue:4

    Topics: Acetaminophen; Humans; Kidney Papillary Necrosis; Legislation, Drug; Nephritis, Interstitial; Phenac

1980
Risk factors between analgesic use and chronic nephropathy in Thailand.
    The Southeast Asian journal of tropical medicine and public health, 1996, Volume: 27, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ca

1996
Paracetamol induced acute interstitial nephritis superimposed on mesangiocapillary glomerulonephritis.
    Acta physiologica Hungarica, 1996, Volume: 84, Issue:4

    Topics: Acetaminophen; Adult; Alcoholism; Anti-Inflammatory Agents, Non-Steroidal; Glomerulonephritis, Membr

1996
[Paracetamol-induced tubulointerstitial nephritis in a chronic alcoholic patient].
    Orvosi hetilap, 1998, Oct-04, Volume: 139, Issue:40

    Topics: Acetaminophen; Acute Disease; Adult; Alcoholism; Biopsy; Chemical and Drug Induced Liver Injury; Chr

1998
Analgesic-associated nephropathy in the U.S.A.: epidemiologic, clinical and pathogenetic features.
    Kidney international, 1978, Volume: 13, Issue:1

    Topics: Acetaminophen; Adult; Aged; Analgesics; Animals; Aspirin; Creatinine; Drug Combinations; Female; Fol

1978
Analgesic nephropathy.
    The Medical journal of Australia, 1976, May-15, Volume: 1, Issue:20

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Co

1976
Renal magnesium wasting associated with acetaminophen abuse.
    Connecticut medicine, 1992, Volume: 56, Issue:8

    Topics: Acetaminophen; Aged; Female; Humans; Injections, Intravenous; Magnesium; Magnesium Deficiency; Nephr

1992
Acute interstitial nephritis superimposed on glomerulonephritis: report of a case.
    Pediatric nephrology (Berlin, Germany), 1991, Volume: 5, Issue:2

    Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Child; Glomerulonephritis; Hematuria; Humans; Mal

1991
Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: a prospective collaborative study.
    Clinical nephrology, 1986, Volume: 25, Issue:6

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Anti-Inflammatory Agents; Biopsy; Female; Glafenine;

1986
Analgesic use by leprosy patients.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1986, Volume: 54, Issue:3

    Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Female; Humans; Kidney Papillary Necrosis; Leprosy;

1986
Acetaminophen, valadol, and analgesic renal injury.
    The Medical letter on drugs and therapeutics, 1971, Volume: 13, Issue:18

    Topics: Acetaminophen; Analgesics; Aspirin; Humans; Kidney Diseases; Kidney Papillary Necrosis; Nephritis, I

1971
Analgesic nephropathy. A common form of renal disease in Australia.
    The Medical journal of Australia, 1969, Dec-06, Volume: 2, Issue:23

    Topics: Acetaminophen; Analgesics; Anemia; Animals; Aspirin; Australia; Caffeine; Diagnosis, Differential; D

1969