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acetaminophen and Injury, Ischemia-Reperfusion

acetaminophen has been researched along with Injury, Ischemia-Reperfusion in 17 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

ExcerptRelevanceReference
" This permitted studies of whether transplanted KC could affect outcomes in the context of acetaminophen hepatotoxicity or hepatic ischemia-reperfusion injury."3.83Kupffer Cell Transplantation in Mice for Elucidating Monocyte/Macrophage Biology and for Potential in Cell or Gene Therapy. ( Bhargava, KK; Follenzi, A; Gupta, S; Merlin, S; Palestro, CJ; Prat, M; Ranaldo, G; Santambrogio, L; Zanolini, D, 2016)
"Necrosis is typically the consequence of acute metabolic perturbation with ATP depletion as occurs in ischemia/reperfusion and acute drug-induced hepatotoxicity."2.43Apoptosis and necrosis in the liver: a tale of two deaths? ( Gores, GJ; Lemasters, JJ; Malhi, H, 2006)
" However, comprehensive dose-response and time course studies have not yet been done."1.39Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. ( Bajt, ML; Jaeschke, H; Lebofsky, M; McGill, MR; Norris, HR; Rollins, DE; Slawson, MH; Wilkins, DG; Williams, CD; Xie, Y, 2013)
"Only ventricular arrhythmias defined by the Lambeth Conventions were investigated."1.34Antiarrhythmic properties of acetaminophen in the dog. ( Baliga, SS; Golfetti, R; Hadzimichalis, NS; Jaques, KM; Merrill, GF; Merrill, JH; Rork, TH, 2007)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.88)18.2507
2000's4 (23.53)29.6817
2010's12 (70.59)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kleinschmidt, D1
Giannou, AD1
McGee, HM1
Kempski, J1
Steglich, B1
Huber, FJ1
Ernst, TM1
Shiri, AM1
Wegscheid, C1
Tasika, E1
Hübener, P1
Huber, P1
Bedke, T1
Steffens, N1
Agalioti, T1
Fuchs, T1
Noll, J1
Lotter, H1
Tiegs, G1
Lohse, AW1
Axelrod, JH1
Galun, E1
Flavell, RA1
Gagliani, N1
Huber, S1
McGill, MR1
Lebofsky, M1
Norris, HR1
Slawson, MH1
Bajt, ML1
Xie, Y1
Williams, CD1
Wilkins, DG1
Rollins, DE1
Jaeschke, H3
Koşucu, M1
Coşkun, I1
Eroglu, A1
Kutanis, D1
Menteşe, A1
Karahan, SC1
Baki, E1
Kerimoğlu, S1
Topbas, M1
Yang, H1
Wang, H1
Ju, Z1
Ragab, AA1
Lundbäck, P1
Long, W1
Valdes-Ferrer, SI1
He, M1
Pribis, JP1
Li, J1
Lu, B1
Gero, D1
Szabo, C1
Antoine, DJ1
Harris, HE1
Golenbock, DT1
Meng, J1
Roth, J1
Chavan, SS1
Andersson, U1
Billiar, TR1
Tracey, KJ1
Al-Abed, Y1
Szabo, G2
Petrasek, J1
Woolbright, BL1
Richards, JA1
Bucsaiova, M1
Hesketh, EE1
Ventre, C1
Henderson, NC1
Simpson, K1
Bellamy, CO1
Howie, SE1
Anderton, SM1
Hughes, J1
Wigmore, SJ1
Merlin, S1
Bhargava, KK1
Ranaldo, G1
Zanolini, D1
Palestro, CJ1
Santambrogio, L1
Prat, M1
Follenzi, A1
Gupta, S1
Baliga, SS3
Jaques-Robinson, KM1
Hadzimichalis, NM1
Golfetti, R2
Merrill, GF3
Shinohara, ML1
Denhardt, DT1
Nath, B1
Kubes, P1
Mehal, WZ1
Malhi, H1
Gores, GJ1
Lemasters, JJ1
Bilzer, M1
Roggel, F1
Gerbes, AL1
Merrill, JH1
Jaques, KM1
Hadzimichalis, NS1
Rork, TH1
Ramaiah, SK1
Nakamoto, K1
Kamisaki, Y1
Wada, K1
Kawasaki, H1
Itoh, T1

Reviews

7 reviews available for acetaminophen and Injury, Ischemia-Reperfusion

ArticleYear
Inflammasome activation and function in liver disease.
    Nature reviews. Gastroenterology & hepatology, 2015, Volume: 12, Issue:7

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Disease Prog

2015
Sterile inflammation in acute liver injury: myth or mystery?
    Expert review of gastroenterology & hepatology, 2015, Volume: 9, Issue:8

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Hepatitis; HMGB1 Protei

2015
Hypoxia and hypoxia inducible factors: diverse roles in liver diseases.
    Hepatology (Baltimore, Md.), 2012, Volume: 55, Issue:2

    Topics: Acetaminophen; Animals; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunity, Innate; Lipid Metabol

2012
Sterile inflammation in the liver.
    Gastroenterology, 2012, Volume: 143, Issue:5

    Topics: Acetaminophen; Adenosine Triphosphate; Caspase 1; Chemical and Drug Induced Liver Injury; Chemotaxis

2012
Apoptosis and necrosis in the liver: a tale of two deaths?
    Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:2 Suppl 1

    Topics: Acetaminophen; Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cholestasis, Intrahepati

2006
Role of Kupffer cells in host defense and liver disease.
    Liver international : official journal of the International Association for the Study of the Liver, 2006, Volume: 26, Issue:10

    Topics: Acetaminophen; Animals; Cell Communication; Fatty Liver; Hemoglobins; Humans; Immune Tolerance; Immu

2006
Role of neutrophils in the pathogenesis of acute inflammatory liver injury.
    Toxicologic pathology, 2007, Volume: 35, Issue:6

    Topics: Acetaminophen; Acute Disease; Animals; Cell Adhesion; Cell Movement; Hepatitis, Alcoholic; Humans; I

2007

Trials

1 trial available for acetaminophen and Injury, Ischemia-Reperfusion

ArticleYear
The effects of spinal, inhalation, and total intravenous anesthetic techniques on ischemia-reperfusion injury in arthroscopic knee surgery.
    BioMed research international, 2014, Volume: 2014

    Topics: Acetaminophen; Adolescent; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Spina

2014

Other Studies

9 other studies available for acetaminophen and Injury, Ischemia-Reperfusion

ArticleYear
A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury.
    Journal of immunology (Baltimore, Md. : 1950), 2017, 12-15, Volume: 199, Issue:12

    Topics: Acetaminophen; Animals; Cell Movement; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chem

2017
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.
    Toxicology and applied pharmacology, 2013, Jun-15, Volume: 269, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Respo

2013
MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.
    The Journal of experimental medicine, 2015, Jan-12, Volume: 212, Issue:1

    Topics: Acetaminophen; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cells, Cultured; Chemical an

2015
Acute Liver Injury Is Independent of B Cells or Immunoglobulin M.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Acetaminophen; Acute Lung Injury; Animals; B-Lymphocytes; Chemical and Drug Induced Liver Injury; Di

2015
Kupffer Cell Transplantation in Mice for Elucidating Monocyte/Macrophage Biology and for Potential in Cell or Gene Therapy.
    The American journal of pathology, 2016, Volume: 186, Issue:3

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; G

2016
Acetaminophen reduces mitochondrial dysfunction during early cerebral postischemic reperfusion in rats.
    Brain research, 2010, Mar-10, Volume: 1319

    Topics: Acetaminophen; Animals; Apoptosis; Brain; Brain Ischemia; Carotid Artery Diseases; Caspase 9; Cytoch

2010
Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen.
    PloS one, 2011, Jan-21, Volume: 6, Issue:1

    Topics: Acetaminophen; Animals; Brain Ischemia; Cerebral Cortex; Gene Expression; Osteopontin; Rats; Reperfu

2011
Antiarrhythmic properties of acetaminophen in the dog.
    Experimental biology and medicine (Maywood, N.J.), 2007, Volume: 232, Issue:9

    Topics: Acetaminophen; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Drug Administration Rout

2007
Protective effect of acetaminophen against acute gastric mucosal lesions induced by ischemia-reperfusion in the rat.
    Pharmacology, 1997, Volume: 54, Issue:4

    Topics: Acetaminophen; Acute Disease; Animals; Antioxidants; Dinoprostone; Free Radicals; Gastric Mucosa; Li

1997