acetaminophen has been researched along with Inflammatory Response Syndrome, Systemic in 17 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The systemic inflammatory response syndrome (SIRS) and sequential organ failure assessment (SOFA) scores are widely used as prognostic markers in critical care settings and could improve triage of high-risk paracetamol (acetaminophen) overdose patients." | 7.77 | The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose. ( Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Reid, TW; Simpson, KJ, 2011) |
| "Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure." | 7.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "Macrophage activation is implicated in the pathogenesis of the systemic inflammatory response syndrome (SIRS) following paracetamol (acetaminophen) overdose (POD)." | 3.79 | Serum neopterin and soluble CD163 as markers of macrophage activation in paracetamol (acetaminophen)-induced human acute liver injury. ( Craig, DG; Hayes, PC; Lee, P; Pryde, EA; Simpson, KJ, 2013) |
| "In acetaminophen-induced acute liver failure (ALF), the hepatic coma grade worsens and mortality rates increase, as the number of systemic inflammatory response syndrome components fulfilled (SIRS score) increases." | 3.78 | SIRS score reflects clinical features of non-acetaminophen-related acute liver failure with hepatic coma. ( Ikeda, F; Miyake, Y; Nouso, K; Takaki, A; Yamamoto, K; Yasunaka, T, 2012) |
| "The systemic inflammatory response syndrome (SIRS) and sequential organ failure assessment (SOFA) scores are widely used as prognostic markers in critical care settings and could improve triage of high-risk paracetamol (acetaminophen) overdose patients." | 3.77 | The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose. ( Craig, DG; Davidson, JS; Hayes, PC; Martin, KG; Reid, TW; Simpson, KJ, 2011) |
| "We performed a retrospective study of medical intensive care unit and surgical intensive care unit patients with systemic inflammatory response syndrome and compared the resolution of fever in the presence and absence of acetaminophen treatment by comparing the absolute reduction in body temperature and the rate of cooling over comparable time frames in fevers that were untreated and those treated with acetaminophen." | 3.76 | Acetaminophen has limited antipyretic activity in critically ill patients. ( Chen, H; Greenberg, RS; Hasday, JD, 2010) |
| "Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure." | 3.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "Significant morbidity associated with acute liver failure (ALF) is from the systemic inflammatory response syndrome (SIRS)." | 1.39 | Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure. ( Brunn, GJ; Fisher, JE; Juskewitch, JE; Lillegard, JB; Malhi, H; McKenzie, TJ; Nedredal, GI; Nyberg, SL; Smyrk, TC; Yi, ES; Yu, Y, 2013) |
| "Acetaminophen (APAP) is a safe analgesic and antipyretic drug." | 1.38 | Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. ( Amaral, SS; Avila, TV; Cara, DC; De Paula, AM; Leite, MF; Lima, BH; Lima, CX; Lopes, GA; Marques, PE; Melgaço, JG; Menezes, GB; Nogueira, LL; Oliveira, AG; Pinto, MA; Pires, DA; Russo, RC; Soriani, FM; Teixeira, MM, 2012) |
| "Progression of hepatic encephalopathy (HE) is a major determinant of outcome in acute liver failure (ALF)." | 1.32 | Infection and the progression of hepatic encephalopathy in acute liver failure. ( Blei, AT; Chung, C; Helenowski, I; Lee, WM; Polson, J; Reisch, J; Schiodt, FV; Vaquero, J, 2003) |
| "In addition to signs of acute liver failure with a systemic inflammatory response syndrome, these three previously healthy young women demonstrated cutaneous vasoconstriction." | 1.32 | Coingestion of cyclooxygenase inhibitors can worsen severe paracetamol poisoning by middle-sized and small arteries vasoconstriction. ( Assemi, P; Castelain, V; Lavigne, T; Meyer, C; Meziani, F; Neuville, A; Schneider, F, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 10 (58.82) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| von Meijenfeldt, FA | 1 |
| Stravitz, RT | 1 |
| Zhang, J | 1 |
| Adelmeijer, J | 1 |
| Zen, Y | 1 |
| Durkalski, V | 1 |
| Lee, WM | 2 |
| Lisman, T | 1 |
| Craig, DG | 4 |
| Lee, P | 2 |
| Pryde, EA | 2 |
| Hayes, PC | 4 |
| Simpson, KJ | 4 |
| Bernsmeier, C | 2 |
| Antoniades, CG | 1 |
| Wendon, J | 2 |
| Kitto, L | 1 |
| Zafar, S | 1 |
| Reid, TW | 2 |
| Martin, KG | 2 |
| Davidson, JS | 2 |
| Manakkat Vijay, GK | 1 |
| Ryan, JM | 1 |
| Abeles, RD | 1 |
| Ramage, S | 1 |
| Patel, V | 1 |
| Riva, A | 1 |
| McPhail, MJ | 1 |
| Tranah, TH | 1 |
| Markwick, LJ | 1 |
| Taylor, NJ | 1 |
| Bernal, W | 1 |
| Auzinger, G | 1 |
| Willars, C | 1 |
| Chokshi, S | 1 |
| Wendon, JA | 1 |
| Ma, Y | 1 |
| Shawcross, DL | 1 |
| Greenberg, RS | 1 |
| Chen, H | 1 |
| Hasday, JD | 1 |
| Miyake, Y | 1 |
| Yasunaka, T | 1 |
| Ikeda, F | 1 |
| Takaki, A | 1 |
| Nouso, K | 1 |
| Yamamoto, K | 1 |
| Marques, PE | 1 |
| Amaral, SS | 1 |
| Pires, DA | 1 |
| Nogueira, LL | 1 |
| Soriani, FM | 1 |
| Lima, BH | 1 |
| Lopes, GA | 1 |
| Russo, RC | 1 |
| Avila, TV | 1 |
| Melgaço, JG | 1 |
| Oliveira, AG | 1 |
| Pinto, MA | 1 |
| Lima, CX | 1 |
| De Paula, AM | 1 |
| Cara, DC | 1 |
| Leite, MF | 1 |
| Teixeira, MM | 1 |
| Menezes, GB | 1 |
| Walker, SW | 1 |
| Beckett, GJ | 1 |
| Fisher, JE | 1 |
| McKenzie, TJ | 1 |
| Lillegard, JB | 1 |
| Yu, Y | 1 |
| Juskewitch, JE | 1 |
| Nedredal, GI | 1 |
| Brunn, GJ | 1 |
| Yi, ES | 1 |
| Malhi, H | 1 |
| Smyrk, TC | 1 |
| Nyberg, SL | 1 |
| Vaquero, J | 1 |
| Polson, J | 1 |
| Chung, C | 1 |
| Helenowski, I | 1 |
| Schiodt, FV | 1 |
| Reisch, J | 1 |
| Blei, AT | 1 |
| Schneider, F | 1 |
| Neuville, A | 1 |
| Meziani, F | 1 |
| Meyer, C | 1 |
| Assemi, P | 1 |
| Lavigne, T | 1 |
| Castelain, V | 1 |
| Gozzoli, V | 1 |
| Treggiari, MM | 1 |
| Kleger, GR | 1 |
| Roux-Lombard, P | 1 |
| Fathi, M | 1 |
| Pichard, C | 1 |
| Romand, JA | 1 |
| Humphreys, BD | 1 |
| Forman, JP | 1 |
| Zandi-Nejad, K | 1 |
| Bazari, H | 1 |
| Seifter, J | 1 |
| Magee, CC | 1 |
| Schmidt, LE | 1 |
| Larsen, FS | 1 |
| Rolando, N | 1 |
| Wade, J | 1 |
| Davalos, M | 1 |
| Philpott-Howard, J | 1 |
| Williams, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.[NCT02280239] | Phase 4 | 10 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to Only enrolled 10 participants over 9 months which is less then anticipated (75).) | ||
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| Early Lactate-Directed Therapy on the ICU: A Randomized Controlled Trial[NCT00270673] | Phase 3 | 350 participants (Anticipated) | Interventional | 2006-02-28 | Completed | ||
| Use of HA 330-II for Hemofiltration in Patients With Acute Liver Failure as a Bridge to Liver Transplantation: Clinical Evaluation Protocol.[NCT04243655] | Phase 4 | 10 participants (Anticipated) | Interventional | 2019-12-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinically significant hypotension is defined as an acute drop in mean arterial pressure requiring treatment. Treatment is defined as either a 500 cc (or greater) fluid bolus and/or an increase in inotrope support of greater than 5 mcg/min over baseline. (NCT02280239)
Timeframe: 4 hours post acetaminophen administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Control Group | 0 |
| Acetaminophen Group | 0 |
systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressures (MAP) will be monitored for 4 hours post intervention (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mmHg (Mean) | |||||
|---|---|---|---|---|---|---|
| SBP: Pre-Intervention (2 hours) | SBP: Post-Intervention (4 hours) | DBP: Pre-Intervention (2 hours) | DBP: Post-Intervention (4 hours) | MAP: Pre-Intervention (2 hours) | MAP: Post-Intervention (4 hours) | |
| Acetaminophen Group | 122.6 | 119.5 | 66.2 | 65.4 | 84.1 | 82.4 |
| Control Group | 141.6 | 141.5 | 57.4 | 51.0 | 80.8 | 75.5 |
"Total dose of all vasoactive medications will be converted to total Equidose value (with the formula 10 mcg/min norepinephrine ≈ 5 mcg/kg/min dopamine ≈ 10 mcg/min epinephrine ≈ 1 mcg/min phenylephrine ≈ 0.02 u/min vasopressin as per Russell et al. (2008)) before comparing the treatment and control groups~Only 2 of the 6 participants were on low-dose vasoactive medications, (i.e., one was on norepinephrine and the other was on milrinone) therefore the pre-planned conversion calculation was not done." (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mcg (Number) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) TOTAL Norepinephrine | Pre-Intervention (2 hours) TOTAL Milrinone | Post-Intervention (4 hours) TOTAL Norepinephrine | Post-Intervention (4 hours) TOTAL Milrinone | |
| Acetaminophen Group | NA | 6000.0 | NA | 7000.0 |
| Control Group | 167.0 | NA | 576.0 | NA |
Total crystalloid and colloid fluid will be converted the the equi-volume dose (with the ratio 1.4:1 (as per Finfer et al.(2004) & Vincent and Weil (2006) before making comparisons between the treatment and control groups. (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mL (Mean) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) Total fluid INTAKE | Pre-Intervention (2 hours) Total fluid OUTPUT | Post-Intervention (4 hours) Total Fluid INTAKE | Post-Intervention (4 hours) Total Fluid OUTPUT | |
| Acetaminophen Group | 298 | 370 | 612 | 852 |
| Control Group | 235 | 80 | 734 | 245 |
"Continuous measurements of core body temperature will be recorded for 6 hours. Fever burden (FB) is defined as area between the 6 hour temperature curve and 38.3°C cut-off and it is reported in °C-hour.~PRE-INTERVENTION FB: is reported for a 2 hour period. POST-INTERVENTION FB: post-intervention fever burden is reported for a 6 hour period and average hourly fever burden.~Peak Temperature: is the highest recorded temperature for the study period in °C Minimum Temperature: is the lowest recorded temperature for the study period in °C" (NCT02280239)
Timeframe: 6 hours post intervention
| Intervention | °C*hours (Mean) | |
|---|---|---|
| Pre-Intervention FB (2 hours) | Post-Intervention FB (6 hours) | |
| Acetaminophen Group | 2.16 | 5.65 |
| Control Group | 0.97 | 0.74 |
1 trial available for acetaminophen and Inflammatory Response Syndrome, Systemic
| Article | Year |
|---|---|
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Body Temperature; Cryotherapy; Cytoki | 2004 |
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Body Temperature; Cryotherapy; Cytoki | 2004 |
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Body Temperature; Cryotherapy; Cytoki | 2004 |
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Body Temperature; Cryotherapy; Cytoki | 2004 |
16 other studies available for acetaminophen and Inflammatory Response Syndrome, Systemic
| Article | Year |
|---|---|
Generation of neutrophil extracellular traps in patients with acute liver failure is associated with poor outcome.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cell-Free Nucleic Acids; Disease Progression; Extrac | 2022 |
Serum neopterin and soluble CD163 as markers of macrophage activation in paracetamol (acetaminophen)-induced human acute liver injury.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Antigens, CD; Antigens, Differentiation, Myelo | 2013 |
What's new in acute liver failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bi | 2014 |
An elevated neutrophil-lymphocyte ratio is associated with adverse outcomes following single time-point paracetamol (acetaminophen) overdose: a time-course analysis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdos | 2014 |
Neutrophil Toll-Like Receptor 9 Expression and the Systemic Inflammatory Response in Acetaminophen-Induced Acute Liver Failure.
Topics: Acetaminophen; Adult; Cohort Studies; Female; Humans; Liver Failure, Acute; Male; Middle Aged; Neutr | 2016 |
Acetaminophen has limited antipyretic activity in critically ill patients.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Critical Care; Critical Illness; Female; | 2010 |
The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Liver Failure, Acute; | 2011 |
SIRS score reflects clinical features of non-acetaminophen-related acute liver failure with hepatic coma.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Female; Hepatic Encephalopathy; Humans; L | 2012 |
Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure.
Topics: Acetaminophen; Acute Lung Injury; Acute-Phase Reaction; Adolescent; Adult; Analysis of Variance; Ani | 2012 |
Elevated levels of the long pentraxin 3 in paracetamol-induced human acute liver injury.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Area Under Curve; Bacterial Infections; Biomar | 2013 |
Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; HEK293 Cells; Humans; Kupffer Cells; Lipopolysacch | 2013 |
Infection and the progression of hepatic encephalopathy in acute liver failure.
Topics: Acetaminophen; Adult; Disease Progression; Female; Hepatic Encephalopathy; Humans; Infections; Liver | 2003 |
Coingestion of cyclooxygenase inhibitors can worsen severe paracetamol poisoning by middle-sized and small arteries vasoconstriction.
Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Angiography; Anti-Inflammatory | 2003 |
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Analgesics, Non-Narcotic; Antineoplastic Comb | 2005 |
Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Female; Hepatic Encephalopa | 2006 |
The systemic inflammatory response syndrome in acute liver failure.
Topics: Acetaminophen; Anti-Bacterial Agents; Hepatic Encephalopathy; Humans; Liver Failure, Acute; Liver Tr | 2000 |