acetaminophen has been researched along with Inflammation in 213 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the present study was to investigate the analgesic and anti-inflammatory effects of dexketoprofen trometamol (DT) and paracetamol on deep acute somatic pain and inflammation in patients undergoing impacted third molar surgery." | 9.19 | Effect of low-dose dexketoprofen trometamol and paracetamol on postoperative complications after impacted third molar surgery on healthy volunteers: A pilot study. ( Durmus, E; Eroglu, CN; Kiresi, D, 2014) |
| "The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever." | 9.07 | A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children. ( Comito, A; Pieragostini, P; Polidori, G; Scaricabarozzi, I; Titti, G, 1993) |
| " The use of acetaminophen in babies and young children may be much more strongly associated with autism than its use during pregnancy, perhaps because of well-known deficiencies in the metabolic breakdown of pharmaceuticals during early development." | 8.95 | The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism. ( Bilbo, S; Gentry, L; Herbert, MR; Holzknecht, ZE; Hornik, CD; Lin, SS; Nevison, CD; Parker, W; Rao, R, 2017) |
| "Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well-publicized guidelines for its early detection and treatment." | 8.31 | Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. ( Alabbas, SY; Begun, J; Davies, J; Florin, TH; Giri, R; Oancea, I; Schreibner, V, 2023) |
| "Acetaminophen (APAP) exposure early in life has been associated with increased risk of neurodevelopmental disorders in epidemiological studies." | 8.12 | Interleukin-1β-induced inflammation and acetaminophen during infancy: Distinct and interactive effects on social-emotional and repetitive behavior in C57BL/6J mice. ( Harshaw, C; Warner, AG, 2022) |
| "Mitochondrial complex I inhibitor rotenone protected kidneys against APAP-induced injury possibly via the inhibition of mitochondrial oxidative stress and inflammation." | 7.88 | Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation. ( Chen, L; Ge, X; Hua, H; Huang, S; Jia, Z; Wu, M; Yang, G; Zhang, A; Zhang, Y; Zhu, C, 2018) |
| "The aim of the present study was to reveal the possible effect of sulforaphane on oxidative stress and inflammation in rats liver with toxic hepatitis induced by acetaminophene." | 7.85 | The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene. ( Aktas, MS; Dokumacioglu, A; Dokumacioglu, E; Hanedan, B; Iskender, H; Musmul, A; Sen, TM, 2017) |
| "During pregnancy, acetaminophen is one of the very few medications recommended by physicians to treat fever or pain." | 7.81 | Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring. ( Arck, P; Barikbin, R; Erhardt, A; Huebener, P; Karimi, K; Keßler, T; Ramisch, K; Thiele, K; Tiegs, G, 2015) |
| " perforatum extract on paracetamol (acetaminophen)-induced hepatotoxicity, lethality, inflammation, and oxidative stress in male swiss mice were investigated." | 7.81 | Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress. ( Arakawa, NS; Cardoso, RD; Casagrande, R; Fattori, V; Hohmann, MS; Lopes, NP; Tomaz, JC; Verri, WA, 2015) |
| "Plasma concentrations and pharmacokinetics of phenacetin, a CYP1A2 substrate were determined in normal and experimentally induced inflamed rats by turpentine oil to know the role of inflammation on the pharmacokinetics of phenacetin and formation of its active metabolite (paracetamol) by CYP1A2 in wistar albino rats, weighing about 200-250 g that were randomly divided into two groups consisting six in each group." | 7.81 | Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats. ( Anand Kumar, P; Prasad, VG; Rao, GS; Ravi Kumar, P; Vivek, Ch, 2015) |
| "The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress." | 7.80 | Association between recent acetaminophen use and asthma: modification by polymorphism at TLR4. ( Hong, K; Hong, SJ; Jung, YH; Kang, MJ; Kim, BJ; Kim, HB; Kim, HJ; Kim, HS; Kim, HY; Kim, YJ; Kwon, JW; Lee, SH; Lee, SY; Park, KS; Seo, JH; Yu, HS, 2014) |
| "Effects of different doses of aspirin, compared to equimolar doses of nitric oxide (NO)-donating aspirin (NCX 4016), and of a single dose of paracetamol, compared to an equimolar dose of NO-donating paracetamol (NCX 701) were investigated in acute zymosan-induced air pouch inflammation in rats." | 7.74 | Effect of aspirin, paracetamol and their nitric oxide donating derivatives on exudate cytokine and PGE2 production in zymosan-induced air pouch inflammation in rats. ( Mamuk, S; Melli, M, 2007) |
| "This study, performed in freely moving rats, evaluates the effects of the two most prescribed analgesics, aspirin and acetaminophen, on carrageenin inflammation and the associated c-Fos expression in the rat lumbar spinal cord." | 7.69 | Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenin inflammation. ( Besson, JM; Buritova, J; Honoré, P, 1995) |
| "Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury after an overdose." | 6.66 | Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. ( Jaeschke, H; Ramachandran, A, 2020) |
| "Inflammation is a critical component of the overall pathophysiology, not only as a potential factor that may aggravate cell damage, but more importantly as a vital response to limit cell injury, remove cell debris and promote regeneration." | 6.43 | Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity. ( Jaeschke, H, 2005) |
| " The literature shows that excessive or long-term use of APAP can lead to increased cardiovascular dysfunction." | 5.91 | Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease. ( Feng, X; Fu, D; Hu, C; Huang, Y; Jiang, X; Li, Y; Wen, J; Wu, S; Xin, J; You, T, 2023) |
| "Abietic acid has been known to exhibit anti-inflammatory activity." | 5.91 | Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis. ( An, Y; Guan, L; Han, D; Luo, Q, 2023) |
| "Acetaminophen (APAP) can cause acute liver failure, but treatment options are still limited." | 5.72 | Kahweol Protects against Acetaminophen-Induced Hepatotoxicity in Mice through Inhibiting Oxidative Stress, Hepatocyte Death, and Inflammation. ( Kim, GM; Kim, JY; Leem, J, 2022) |
| "Acetaminophen (APAP) is a first choice for relieving mild-to-moderate pain." | 5.62 | Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress. ( Alen, R; Boscá, L; Brea, R; Casado, M; Fuertes-Agudo, M; García-Monzón, C; Martín-Sanz, P; Rada, P; Valdecantos, P; Valverde, ÁM, 2021) |
| "Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can induce acute liver failure with lack of effective therapies." | 5.56 | Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. ( Chen, Y; He, Z; Jiang, R; Kuang, G; Wan, J; Ye, D; Zhang, L, 2020) |
| "Shikonin is a natural product with antioxidant and anti-inflammatory activities." | 5.51 | Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation. ( Chen, F; Guo, H; Hu, Y; Hua, H; Jia, Z; Jing, X; Li, D; Sun, J; Xu, J; Yu, X, 2019) |
| "Kaempferol pretreatment (125 mg/kg) before propacetamol injection significantly decreased propacetamol-induced serum ALT and AST activities, and DNA fragmentation." | 5.48 | Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice. ( Ko, JL; Lai, YY; Liou, GG; Tsai, MS; Tsou, HK; Wang, SH; Wang, YH, 2018) |
| "Chlorogenic acid (CGA) has been reported to prevent acetaminophen (AP)-induced hepatotoxicity when mice were pre-administered orally with CGA for consecutive 7days before AP intoxication in our previous study." | 5.42 | The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation. ( Ji, L; Lu, B; Sheng, Y; Zheng, Z, 2015) |
| "Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity and nephrotoxicity." | 5.38 | Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation. ( Ahmad, ST; Ali, N; Arjumand, W; Nafees, S; Rashid, S; Seth, A; Sultana, S, 2012) |
| " LPS co-treatment produced a leftward shift of the dose-response curve for APAP-induced hepatotoxicity and led to significantly greater tumor necrosis factor-alpha (TNF) production than APAP alone." | 5.36 | Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity. ( Amuzie, CJ; Cantor, GH; Cuff, CF; Ganey, PE; Li, M; Maddox, JF; Newport, SW; Pestka, JJ; Roth, RA; Sparkenbaugh, E, 2010) |
| "Inflammation was induced in one hind paw of rats by intraplantar injection of 250 microg lambda-carrageenan (CG) and the contralateral paw injected with saline." | 5.35 | Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. ( Bakhle, YS; dos Reis, WG; França, DS; Francischi, JN; Menezes, GB; Rezende, RM, 2008) |
| "The aim of the present study was to investigate the analgesic and anti-inflammatory effects of dexketoprofen trometamol (DT) and paracetamol on deep acute somatic pain and inflammation in patients undergoing impacted third molar surgery." | 5.19 | Effect of low-dose dexketoprofen trometamol and paracetamol on postoperative complications after impacted third molar surgery on healthy volunteers: A pilot study. ( Durmus, E; Eroglu, CN; Kiresi, D, 2014) |
| " The aim was to explore the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg administered intravenously on experimental pain models in human beings." | 5.15 | A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination. ( Besson, M; Daali, Y; Dayer, P; Desmeules, J; Ing Lorenzini, K; Salomon, D, 2011) |
| "The efficacy and tolerability of nimesulide were assessed and compared with those of paracetamol in the treatment of 35 children with pain and inflammation following adenotonsillectomy." | 5.07 | An assessment of the efficacy and tolerability of nimesulide vs paracetamol in children after adenotonsillectomy. ( D'Agostino, R; Pasquale, G; Scaricabarozzi, I; Taborelli, G; Vallarino, R, 1993) |
| "The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever." | 5.07 | A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children. ( Comito, A; Pieragostini, P; Polidori, G; Scaricabarozzi, I; Titti, G, 1993) |
| " The use of acetaminophen in babies and young children may be much more strongly associated with autism than its use during pregnancy, perhaps because of well-known deficiencies in the metabolic breakdown of pharmaceuticals during early development." | 4.95 | The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism. ( Bilbo, S; Gentry, L; Herbert, MR; Holzknecht, ZE; Hornik, CD; Lin, SS; Nevison, CD; Parker, W; Rao, R, 2017) |
| "Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well-publicized guidelines for its early detection and treatment." | 4.31 | Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. ( Alabbas, SY; Begun, J; Davies, J; Florin, TH; Giri, R; Oancea, I; Schreibner, V, 2023) |
| " Acetaminophen (APAP or paracetamol) overdose is a leading cause of ALF, resulting in hepatocellular necrosis with subsequent inflammation, inflicting further liver damage." | 4.31 | Hepatic C-X-C chemokine receptor type 6-expressing innate lymphocytes limit detrimental myeloid hyperactivation in acute liver injury. ( Araujo David, B; Batista Carneiro, M; Heymann, F; Kohlhepp, MS; Krenkel, O; Kubes, P; Liepelt, A; Mossanen, JC; Niemietz, PM; Peiseler, M; Tacke, F, 2023) |
| "Excessive acetaminophen (APAP) intake causes oxidative stress and inflammation, leading to fatal hepatotoxicity; however, the mechanism remains unclear." | 4.12 | Hepatic SIRT6 Modulates Transcriptional Activities of FXR to Alleviate Acetaminophen-induced Hepatotoxicity. ( Chen, Y; Cui, T; Duan, S; Gao, Y; Guo, J; Lin, S; Liu, C; Pan, Z; Tang, K; Wu, Z; Xiao, X; Yang, Z; Zhong, C; Zhong, G; Zhong, Y, 2022) |
| " Inflammation and fibrosis were evaluated by transaminases, myeloperoxidase activity, hydroxyproline, and histological evaluation." | 4.12 | Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease. ( Abrante, B; Abreu-González, P; de la Barreda, R; Díaz-Flores, F; González-Paredes, FJ; Hernández-Bustabad, A; Hernández-Guerra, M; Morales-Arraez, D; Quintero, E, 2022) |
| "NETs aggravated liver injury in FVH by promoting fibrin deposition and inflammation." | 4.12 | FGL2-MCOLN3-Autophagy Axis-Triggered Neutrophil Extracellular Traps Exacerbate Liver Injury in Fulminant Viral Hepatitis. ( Chen, T; Gao, Q; Hai, S; Han, M; Hu, J; Huang, D; Li, X; Luo, X; Ning, Q; Wang, H; Wang, X; Wu, D; Wu, W; Xi, D; Yan, W; You, J, 2022) |
| "Acetaminophen (APAP) exposure early in life has been associated with increased risk of neurodevelopmental disorders in epidemiological studies." | 4.12 | Interleukin-1β-induced inflammation and acetaminophen during infancy: Distinct and interactive effects on social-emotional and repetitive behavior in C57BL/6J mice. ( Harshaw, C; Warner, AG, 2022) |
| "The aim of this study was to evaluate the therapeutic ability of CA methanol extract (CAM) in protecting mouse brain and astrocytes from oxidative stress and inflammation induced by Paracetamol, and thus to substantiate the allied traditional/ethnomedical claims of CA." | 3.91 | Protection of mouse brain from paracetamol-induced stress by Centella asiatica methanol extract. ( Baby, S; Dan, VM; Nair, AS; Radhakrishnan, N; Rajendran Nair, AP; Viswanathan, G, 2019) |
| "Inflammation is one of the factors that may increase the sensitivity of hepatic cells to acetaminophen (APAP) induced toxicity." | 3.91 | Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. ( de Kok, TM; Jennen, DGJ; Jiang, J; Kelm, JM; Kleinjans, JC; Messner, S; van Herwijnen, M, 2019) |
| "Mitochondrial complex I inhibitor rotenone protected kidneys against APAP-induced injury possibly via the inhibition of mitochondrial oxidative stress and inflammation." | 3.88 | Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation. ( Chen, L; Ge, X; Hua, H; Huang, S; Jia, Z; Wu, M; Yang, G; Zhang, A; Zhang, Y; Zhu, C, 2018) |
| "Coconut water vinegar has helped to attenuate acetaminophen-induced liver damage by restoring antioxidant activity and suppression of inflammation." | 3.88 | Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice. ( Alitheen, NB; Beh, BK; Ho, WY; Ky, H; Lim, KL; Long, K; Mohamad, NE; Sharifuddin, SA; Yeap, SK, 2018) |
| "The aim of the present study was to reveal the possible effect of sulforaphane on oxidative stress and inflammation in rats liver with toxic hepatitis induced by acetaminophene." | 3.85 | The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene. ( Aktas, MS; Dokumacioglu, A; Dokumacioglu, E; Hanedan, B; Iskender, H; Musmul, A; Sen, TM, 2017) |
| "Plasma concentrations and pharmacokinetics of phenacetin, a CYP1A2 substrate were determined in normal and experimentally induced inflamed rats by turpentine oil to know the role of inflammation on the pharmacokinetics of phenacetin and formation of its active metabolite (paracetamol) by CYP1A2 in wistar albino rats, weighing about 200-250 g that were randomly divided into two groups consisting six in each group." | 3.81 | Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats. ( Anand Kumar, P; Prasad, VG; Rao, GS; Ravi Kumar, P; Vivek, Ch, 2015) |
| " perforatum extract on paracetamol (acetaminophen)-induced hepatotoxicity, lethality, inflammation, and oxidative stress in male swiss mice were investigated." | 3.81 | Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress. ( Arakawa, NS; Cardoso, RD; Casagrande, R; Fattori, V; Hohmann, MS; Lopes, NP; Tomaz, JC; Verri, WA, 2015) |
| "During pregnancy, acetaminophen is one of the very few medications recommended by physicians to treat fever or pain." | 3.81 | Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring. ( Arck, P; Barikbin, R; Erhardt, A; Huebener, P; Karimi, K; Keßler, T; Ramisch, K; Thiele, K; Tiegs, G, 2015) |
| "The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress." | 3.80 | Association between recent acetaminophen use and asthma: modification by polymorphism at TLR4. ( Hong, K; Hong, SJ; Jung, YH; Kang, MJ; Kim, BJ; Kim, HB; Kim, HJ; Kim, HS; Kim, HY; Kim, YJ; Kwon, JW; Lee, SH; Lee, SY; Park, KS; Seo, JH; Yu, HS, 2014) |
| " These results suggest that ceftriaxone, particularly in combinations with ibuprofen, celecoxib, paracetamol, or levetiracetam, may provide useful approach to the clinical treatment of inflammation-related pain." | 3.80 | Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents. ( Boškovic, BD; Kovacevic, JM; Micov, AM; Stepanovic-Petrovic, RM; Tomic, MA, 2014) |
| " This study characterized the manner in which levetiracetam interacts with analgesics (ibuprofen, celecoxib, and paracetamol) and caffeine to suppress hyperalgesia in a model of localized inflammation." | 3.79 | Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA, 2013) |
| " Nevertheless, the anti-inflammatory activity was tested in carrageenan induced paw edema and histamine induced inflammatory tests." | 3.78 | Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. ( Khan, H; Muhammad, N; Saeed, M, 2012) |
| "Administration of indomethacin (10mg/kg), paracetamol (150 mg/kg) and/or different doses of earthworm extract (EE) (50, 100 and 200mg/kg) reduced and restored to normal conditions in a dose-dependent manner of histamine and turpentine induced inflammation, and Brewer's yeast induced pyretic in rats." | 3.75 | Anti-inflammatory and anti-pyretic activities of earthworm extract-Lampito mauritii (Kinberg). ( Balamurugan, M; Cooper, EL; Parthasarathi, K; Ranganathan, LS, 2009) |
| " As model toxic compounds lipopolysaccharide (LPS, inducing inflammation), paracetamol (necrosis), carbon tetrachloride (CCl(4), fibrosis and necrosis) and gliotoxin (apoptosis) were used." | 3.74 | Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity. ( Bauerschmidt, S; Draaisma, AL; Elferink, MG; Groothuis, GM; Merema, MT; Olinga, P; Polman, J; Schoonen, WG, 2008) |
| "Effects of different doses of aspirin, compared to equimolar doses of nitric oxide (NO)-donating aspirin (NCX 4016), and of a single dose of paracetamol, compared to an equimolar dose of NO-donating paracetamol (NCX 701) were investigated in acute zymosan-induced air pouch inflammation in rats." | 3.74 | Effect of aspirin, paracetamol and their nitric oxide donating derivatives on exudate cytokine and PGE2 production in zymosan-induced air pouch inflammation in rats. ( Mamuk, S; Melli, M, 2007) |
| "This study, performed in freely moving rats, evaluates the effects of the two most prescribed analgesics, aspirin and acetaminophen, on carrageenin inflammation and the associated c-Fos expression in the rat lumbar spinal cord." | 3.69 | Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenin inflammation. ( Besson, JM; Buritova, J; Honoré, P, 1995) |
| "Paracetamol promotes early closure of patent ductus arteriosus (PDA), and it may affect inflammation after preterm birth." | 3.01 | Inflammatory biomarkers in very preterm infants during early intravenous paracetamol administration. ( Aikio, O; Hallman, M; Härkin, P; Härmä, A; Leskinen, M; Saarela, T; Salminen, A; Valkama, M, 2021) |
| " However, long-term use of these agents will lead to inevitable side effects, even aggravate cartilage loss." | 3.01 | Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis. ( Chu, Y; Fan, Z; Guo, X; Liang, Z; Ren, W; Wang, W; Zhang, P; Zhou, G, 2023) |
| "Naproxen treatment, irrespective of type of operation, did not require rescue analgesics, while two patients after CTS treated with paracetamol did." | 2.70 | Acute postoperative swelling after hand surgery: an exploratory, double-blind, randomised study with paracetamol, naproxen, and placebo. ( Fyllingen, G; Haugstvedt, JR; Husby, T; Skoglund, LA, 2001) |
| "Acetaminophen is a widely used analgesic for pain management, especially useful in chronic diseases, such as rheumatoid arthritis." | 2.66 | Acetaminophen Oxidation and Inflammatory Markers - A Review of Hepatic Molecular Mechanisms and Preclinical Studies. ( Barcelos, RP; de Carvalho, NR; Reis, SB; Soares, FAA; Stefanello, ST, 2020) |
| "Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury after an overdose." | 2.66 | Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. ( Jaeschke, H; Ramachandran, A, 2020) |
| "However, bleeding was minimal, and the occurrence of hematoma/ecchymosis was not increased with indoprofen." | 2.66 | The effects of indoprofen vs paracetamol on swelling, pain and other events after surgery. ( Olstad, OA; Skjelbred, P, 1986) |
| "Acetaminophen (APAP) is a widely used analgesic and antipyretic drug." | 2.58 | Autophagy and acetaminophen-induced hepatotoxicity. ( Shan, S; Shen, Z; Song, F, 2018) |
| "A careful search for the cause of acute liver failure in each case is of value in determining whether there are specific antidotes available and what the prognosis might be." | 2.44 | Etiologies of acute liver failure. ( Lee, WM; Seremba, E, 2008) |
| "Inflammation is a critical component of the overall pathophysiology, not only as a potential factor that may aggravate cell damage, but more importantly as a vital response to limit cell injury, remove cell debris and promote regeneration." | 2.43 | Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity. ( Jaeschke, H, 2005) |
| "Approximately 75% of patients with tuberous sclerosis complex develop renal angiomyolipomas." | 2.41 | Reduction of postembolization syndrome after ablation of renal angiomyolipoma. ( Bissler, JJ; Donnelly, LF; Johnson, ND; Racadio, J, 2002) |
| "Abietic acid has been known to exhibit anti-inflammatory activity." | 1.91 | Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis. ( An, Y; Guan, L; Han, D; Luo, Q, 2023) |
| " The literature shows that excessive or long-term use of APAP can lead to increased cardiovascular dysfunction." | 1.91 | Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease. ( Feng, X; Fu, D; Hu, C; Huang, Y; Jiang, X; Li, Y; Wen, J; Wu, S; Xin, J; You, T, 2023) |
| " Physical exam parameters were recorded prior to, during, and after the dosing period." | 1.91 | Ocular penetration of oral acetaminophen in horses. ( Hector, RC; Knych, HK; Lee, S; Peraza, J; Terhaar, HM; Wotman, KL, 2023) |
| "Leonurine (Leo) is a natural alkaloid isolated from the herb Leonurus japonicus Houtt." | 1.91 | Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K/AKT signaling pathway in mice. ( Chen, Y; Di, S; Huang, X; Wang, Y; Yu, Y; Zhou, S, 2023) |
| "Acetaminophen (APAP) can cause acute liver failure, but treatment options are still limited." | 1.72 | Kahweol Protects against Acetaminophen-Induced Hepatotoxicity in Mice through Inhibiting Oxidative Stress, Hepatocyte Death, and Inflammation. ( Kim, GM; Kim, JY; Leem, J, 2022) |
| "Acetaminophen (APAP) is a well-known analgesic and antipyretic drug." | 1.62 | Tetrahydroxy stilbene glycoside attenuates acetaminophen-induced hepatotoxicity by UHPLC-Q-TOF/MS-based metabolomics and multivariate data analysis. ( Chen, NH; Gao, Y; Li, JT; Li, L; Li, X; Yang, SW; Zhang, L, 2021) |
| "Acetaminophen (APAP) is a first choice for relieving mild-to-moderate pain." | 1.62 | Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress. ( Alen, R; Boscá, L; Brea, R; Casado, M; Fuertes-Agudo, M; García-Monzón, C; Martín-Sanz, P; Rada, P; Valdecantos, P; Valverde, ÁM, 2021) |
| "Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can induce acute liver failure with lack of effective therapies." | 1.56 | Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. ( Chen, Y; He, Z; Jiang, R; Kuang, G; Wan, J; Ye, D; Zhang, L, 2020) |
| "Shikonin is a natural product with antioxidant and anti-inflammatory activities." | 1.51 | Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation. ( Chen, F; Guo, H; Hu, Y; Hua, H; Jia, Z; Jing, X; Li, D; Sun, J; Xu, J; Yu, X, 2019) |
| "Sterile inflammation is initiated by damage-associated molecular patterns (DAMPs) and a key contributor to acute liver injury (ALI)." | 1.51 | Circulating Peroxiredoxin-1 is a novel damage-associated molecular pattern and aggravates acute liver injury via promoting inflammation. ( Chen, H; Deng, Z; He, Y; Li, S; Liao, X; Meng, J; Peng, S; Peng, Y; Peng, Z; Qiu, S; Tang, D; Tao, L; Tu, S; Yang, H, 2019) |
| "Acetaminophen (APAP)-induced acute liver failure (ALF) is a life-threatening disease with only a few treatment options available." | 1.51 | Liver-specific Bid silencing inhibits APAP-induced cell death in mice. ( Dames, S; Kuhla, A; Maxa, M; Schaeper, U; Vollmar, B, 2019) |
| "Acute liver failure is a serious consequence of acetaminophen (APAP)-induced hepatotoxic liver injury with high rates of morbidity and mortality." | 1.51 | The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice. ( DeMorrow, S; Frampton, G; Grant, S; Jefferson, B; McMillin, M; Petrescu, AD; Williams, E, 2019) |
| "Kaempferol pretreatment (125 mg/kg) before propacetamol injection significantly decreased propacetamol-induced serum ALT and AST activities, and DNA fragmentation." | 1.48 | Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice. ( Ko, JL; Lai, YY; Liou, GG; Tsai, MS; Tsou, HK; Wang, SH; Wang, YH, 2018) |
| "GR consumption improved mechanical and thermal allodynia and mechanical hyperalgesia and improved behavioural changes related to cognitive disturbances, anxiety, and depression." | 1.48 | Ginger rhizome enhances the anti-inflammatory and anti-nociceptive effects of paracetamol in an experimental mouse model of fibromyalgia. ( De la Puerta, R; Fernandez-Arche, A; Garcia-Gimenez, MD; Montserrat-de la Paz, S; Quilez, AM, 2018) |
| "Acetaminophen (APAP) hepatotoxicity remains the leading cause of drug-induced liver injury due to the lack of safe and effective therapeutic agents." | 1.48 | Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice. ( Hua, W; Liu, X; Liu, Y; Wei, Q; Zhao, Z; Zhu, Y, 2018) |
| "We tested whether this parameter and tactile allodynia, the standard pain measure in preclinical studies, show parallels in their response to analgesics and basic mechanisms." | 1.46 | Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia. ( Cañizares, FJ; Cobos, EJ; Entrena, JM; Fernández-Segura, E; Montilla-García, Á; Perazzoli, G; Portillo-Salido, E; Tejada, MÁ, 2017) |
| "Kamebakaurin (KA) is an ent-kaurane diterpenoid known to have anti-inflammatory potential." | 1.46 | Suppressive effect of kamebakaurin on acetaminophen-induced hepatotoxicity by inhibiting lipid peroxidation and inflammatory response in mice. ( Adachi, Y; Aoyagi, Y; Fukuishi, N; Gui, MY; Hitotsuyanagi, Y; Jin, YR; Li, XW; Miura, N; Nonogaki, T; Ohno, N; Takeya, K; Yoshioka, H, 2017) |
| "Chlorogenic acid (CGA) has been reported to prevent acetaminophen (AP)-induced hepatotoxicity when mice were pre-administered orally with CGA for consecutive 7days before AP intoxication in our previous study." | 1.42 | The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation. ( Ji, L; Lu, B; Sheng, Y; Zheng, Z, 2015) |
| "Morin was observed to inhibit APAP-induced increase in PHLPP2 activity ex vivo as well as its association with cellular target Akt1." | 1.42 | Morin mitigates acetaminophen-induced liver injury by potentiating Nrf2 regulated survival mechanism through molecular intervention in PHLPP2-Akt-Gsk3β axis. ( Kakkar, P; Mathur, A; Rizvi, F, 2015) |
| "Acetaminophen is a common analgesic and antipyretic compound which, when administered in high doses, has been associated with significant morbidity and mortality, secondary to hepatic toxicity." | 1.39 | Baccharis trimera improves the antioxidant defense system and inhibits iNOS and NADPH oxidase expression in a rat model of inflammation. ( Araujo, CM; Bianco de Souza, GH; Chaves, MM; Costa, DC; Cruz Padua, Bd; de Brito Magalhaes, CL; Pedrosa, ML; Rossoni Junior, JV; Seiberf, JB; Silva, ME, 2013) |
| "Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity and nephrotoxicity." | 1.38 | Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation. ( Ahmad, ST; Ali, N; Arjumand, W; Nafees, S; Rashid, S; Seth, A; Sultana, S, 2012) |
| "Inflammation is deleterious for organs with reduced capacity of regeneration, such as the brain." | 1.38 | Effects of non-steroidal antiinflammatory drugs on D-serine-induced oxidative stress in vitro. ( Armagan, G; Kanit, L; Yalcin, A, 2012) |
| "In experimental models of acute liver failure SERPINB3 was found significantly increased in microglia, the intrinsic immune cells of the central nervous system." | 1.38 | Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure. ( Amodio, P; Calabrese, F; Campagna, F; Gatta, A; Lunardi, F; Pontisso, P; Schiff, S; Tono, N; Turato, C; Villano, G, 2012) |
| " LPS co-treatment produced a leftward shift of the dose-response curve for APAP-induced hepatotoxicity and led to significantly greater tumor necrosis factor-alpha (TNF) production than APAP alone." | 1.36 | Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity. ( Amuzie, CJ; Cantor, GH; Cuff, CF; Ganey, PE; Li, M; Maddox, JF; Newport, SW; Pestka, JJ; Roth, RA; Sparkenbaugh, E, 2010) |
| "Pretreatment with ketanserin significantly attenuated these effects." | 1.36 | Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache. ( le Grand, SM; Srikiatkhachorn, A; Supornsilpchai, W, 2010) |
| "Inflammation was induced in one hind paw of rats by intraplantar injection of 250 microg lambda-carrageenan (CG) and the contralateral paw injected with saline." | 1.35 | Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. ( Bakhle, YS; dos Reis, WG; França, DS; Francischi, JN; Menezes, GB; Rezende, RM, 2008) |
| " One important example of this type of injury is acetaminophen-induced liver injury, in which the initial toxic injury is followed by innate immune activation." | 1.35 | Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. ( Flavell, RA; Imaeda, AB; Mahmood, S; Mehal, WZ; Mohamadnejad, M; Sohail, MA; Sutterwala, FS; Watanabe, A, 2009) |
| "Colitis was induced in rats by an enema containing 2,4,6-trinitrobenzen sulfonic acid." | 1.32 | Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats. ( Ardid, D; Eschalier, A; Etienne, M; Jourdan, D; Millecamps, M, 2004) |
| " FS 205-397 will offer potent analgesic and antipyretic therapy in man based on an innovative biochemical principle which eliminates the undesirable toxic effects associated with most other non-narcotic analgesics." | 1.27 | FS 205-397: a new antipyretic analgesic with a paracetamol-like profile of activity but lack of acute hepatotoxicity in mice. ( Achini, R; Foote, RW; Römer, D, 1988) |
| " The relative oral/intramuscular bioavailability of amitriptyline was only 13%, and the steady-state concentrations of this drug on four consecutive days were acutely subtherapeutic (i." | 1.27 | Decreased drug absorption in a patient with Behçet's syndrome. ( Atiyeh, M; Chaleby, K; el-Yazigi, A, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (10.80) | 18.7374 |
| 1990's | 5 (2.35) | 18.2507 |
| 2000's | 38 (17.84) | 29.6817 |
| 2010's | 96 (45.07) | 24.3611 |
| 2020's | 51 (23.94) | 2.80 |
| Authors | Studies |
|---|---|
| Epifano, F | 1 |
| Genovese, S | 1 |
| Sosa, S | 1 |
| Tubaro, A | 1 |
| Curini, M | 1 |
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Aikio, O | 1 |
| Härmä, A | 1 |
| Härkin, P | 1 |
| Leskinen, M | 1 |
| Valkama, M | 1 |
| Saarela, T | 1 |
| Salminen, A | 1 |
| Hallman, M | 1 |
| Juri, T | 1 |
| Fujimoto, Y | 1 |
| Suehiro, K | 1 |
| Nishikawa, K | 1 |
| Mori, T | 1 |
| Stülb, H | 1 |
| Bachmann, M | 1 |
| Gonther, S | 1 |
| Mühl, H | 1 |
| Hu, S | 1 |
| Yao, Y | 1 |
| Wei, ZY | 1 |
| Wang, SX | 1 |
| Wu, YC | 1 |
| Hu, Y | 2 |
| Yang, CC | 1 |
| Min, JL | 1 |
| Li, LY | 1 |
| Zhou, H | 2 |
| Yang, JF | 1 |
| Li, J | 5 |
| Xu, T | 1 |
| Martínez-Martínez, MDC | 1 |
| Parra-Flores, LI | 1 |
| Baeza-Flores, GDC | 1 |
| Torres-López, JE | 1 |
| Kim, JY | 2 |
| Leem, J | 1 |
| Kim, GM | 1 |
| Rostami, A | 1 |
| Baluchnejadmojarad, T | 1 |
| Roghani, M | 1 |
| Elsayed, HE | 1 |
| Ebrahim, HY | 1 |
| Mady, MS | 1 |
| Khattab, MA | 1 |
| El-Sayed, EK | 1 |
| Moharram, FA | 1 |
| Cai, X | 1 |
| Cai, H | 1 |
| Wang, J | 2 |
| Yang, Q | 1 |
| Guan, J | 1 |
| Deng, J | 1 |
| Chen, Z | 2 |
| Liu, C | 2 |
| Pan, Z | 1 |
| Wu, Z | 1 |
| Tang, K | 1 |
| Zhong, Y | 1 |
| Chen, Y | 4 |
| Xiao, X | 1 |
| Guo, J | 1 |
| Duan, S | 1 |
| Cui, T | 1 |
| Zhong, G | 1 |
| Yang, Z | 1 |
| Zhong, C | 1 |
| Lin, S | 1 |
| Gao, Y | 5 |
| Yu, T | 1 |
| He, Y | 2 |
| Chen, H | 3 |
| Lu, X | 1 |
| Ni, H | 1 |
| Ma, Y | 2 |
| Li, C | 1 |
| Cao, R | 1 |
| Ma, L | 1 |
| Li, Z | 2 |
| Lei, Y | 1 |
| Luo, X | 2 |
| Zheng, C | 1 |
| Hernández-Bustabad, A | 1 |
| Morales-Arraez, D | 1 |
| González-Paredes, FJ | 1 |
| Abrante, B | 1 |
| Díaz-Flores, F | 1 |
| Abreu-González, P | 1 |
| de la Barreda, R | 1 |
| Quintero, E | 1 |
| Hernández-Guerra, M | 1 |
| Li, X | 7 |
| Gao, Q | 1 |
| Wu, W | 1 |
| Hai, S | 1 |
| Hu, J | 1 |
| You, J | 1 |
| Huang, D | 2 |
| Wang, H | 4 |
| Wu, D | 1 |
| Han, M | 2 |
| Xi, D | 1 |
| Yan, W | 1 |
| Chen, T | 1 |
| Ning, Q | 1 |
| Wang, X | 2 |
| Harshaw, C | 1 |
| Warner, AG | 1 |
| Peraza, J | 2 |
| Hector, RC | 2 |
| Lee, S | 3 |
| Terhaar, HM | 2 |
| Knych, HK | 2 |
| Wotman, KL | 2 |
| Fu, D | 1 |
| Wu, S | 1 |
| Jiang, X | 3 |
| You, T | 1 |
| Li, Y | 1 |
| Xin, J | 1 |
| Feng, X | 1 |
| Wen, J | 1 |
| Huang, Y | 3 |
| Hu, C | 1 |
| Alabbas, SY | 1 |
| Giri, R | 1 |
| Oancea, I | 1 |
| Davies, J | 1 |
| Schreibner, V | 1 |
| Florin, TH | 1 |
| Begun, J | 1 |
| Guo, C | 1 |
| Liu, W | 1 |
| Liu, Z | 1 |
| Cai, J | 1 |
| Yu, X | 2 |
| Zuo, D | 1 |
| Zhang, B | 1 |
| Liu, J | 3 |
| Sanyal, AJ | 1 |
| Puri, P | 1 |
| Wang, XY | 1 |
| Ratajczyk-Socha, N | 1 |
| Olszewski, J | 1 |
| Wang, W | 2 |
| Chu, Y | 1 |
| Zhang, P | 1 |
| Liang, Z | 1 |
| Fan, Z | 1 |
| Guo, X | 1 |
| Zhou, G | 1 |
| Ren, W | 1 |
| Zhao, JH | 1 |
| Zhang, XY | 1 |
| Shi, S | 1 |
| Wang, L | 1 |
| Yuan, ML | 1 |
| Liu, YP | 1 |
| Wang, YD | 1 |
| Li, Q | 2 |
| Zhang, W | 2 |
| Cheng, N | 1 |
| Zhu, Y | 2 |
| Li, H | 2 |
| Zhang, S | 3 |
| Guo, W | 1 |
| Ge, G | 1 |
| An, Y | 1 |
| Luo, Q | 1 |
| Han, D | 1 |
| Guan, L | 1 |
| Heymann, F | 1 |
| Mossanen, JC | 2 |
| Peiseler, M | 1 |
| Niemietz, PM | 1 |
| Araujo David, B | 1 |
| Krenkel, O | 2 |
| Liepelt, A | 1 |
| Batista Carneiro, M | 1 |
| Kohlhepp, MS | 1 |
| Kubes, P | 1 |
| Tacke, F | 2 |
| Li, S | 2 |
| Zhuge, A | 1 |
| Xia, J | 2 |
| Wang, S | 1 |
| Lv, L | 1 |
| Wang, K | 1 |
| Jiang, H | 1 |
| Yan, R | 1 |
| Yang, L | 1 |
| Bian, X | 1 |
| Wang, Q | 1 |
| Han, S | 1 |
| Li, L | 3 |
| Xiang, DD | 1 |
| Liu, JT | 1 |
| Zhong, ZB | 1 |
| Xiong, Y | 1 |
| Kong, HY | 1 |
| Yu, HJ | 1 |
| Peng, T | 1 |
| Huang, JQ | 1 |
| Yu, Y | 1 |
| Zhou, S | 1 |
| Wang, Y | 7 |
| Di, S | 1 |
| Huang, X | 2 |
| Liu, M | 2 |
| Wu, H | 3 |
| Liu, H | 2 |
| Chen, C | 2 |
| Yin, F | 1 |
| Zha, Z | 1 |
| Wang, F | 1 |
| Tian, WS | 1 |
| Zhao, J | 3 |
| Kim, MK | 1 |
| Tae, HJ | 1 |
| Kim, IS | 1 |
| Ahn, D | 1 |
| Hwang, HP | 1 |
| Mao, MX | 1 |
| Park, BY | 1 |
| Li, M | 2 |
| Sun, X | 1 |
| Xia, L | 1 |
| Xu, M | 1 |
| Wang, B | 1 |
| Guo, H | 2 |
| Yu, C | 1 |
| Kong, X | 1 |
| Xia, Q | 1 |
| Varrassi, G | 1 |
| Alon, E | 1 |
| Bagnasco, M | 1 |
| Lanata, L | 1 |
| Mayoral-Rojals, V | 1 |
| Paladini, A | 1 |
| Pergolizzi, JV | 1 |
| Perrot, S | 1 |
| Scarpignato, C | 1 |
| Tölle, T | 1 |
| Maxa, M | 1 |
| Schaeper, U | 1 |
| Dames, S | 1 |
| Vollmar, B | 1 |
| Kuhla, A | 1 |
| Chen, Q | 1 |
| Yan, D | 1 |
| Zhang, Q | 1 |
| Zhang, G | 2 |
| Xia, M | 1 |
| Zhan, W | 1 |
| Shen, E | 1 |
| Lin, L | 1 |
| Chen, YH | 1 |
| Wan, X | 2 |
| Qu, H | 1 |
| Gao, X | 1 |
| Wang, ZY | 1 |
| Yi, JJ | 1 |
| Raevens, S | 1 |
| Van Campenhout, S | 1 |
| Debacker, PJ | 1 |
| Lefere, S | 1 |
| Verhelst, X | 1 |
| Geerts, A | 1 |
| Van Vlierberghe, H | 1 |
| Colle, I | 1 |
| Devisscher, L | 1 |
| Song, M | 1 |
| Shen, C | 1 |
| Zhu, C | 2 |
| Lin, C | 1 |
| Mi, S | 1 |
| Bell, CC | 1 |
| Chouhan, B | 1 |
| Andersson, LC | 1 |
| Andersson, H | 1 |
| Dear, JW | 1 |
| Williams, DP | 2 |
| Söderberg, M | 1 |
| Jaeschke, H | 10 |
| Ramachandran, A | 3 |
| Wan, J | 1 |
| Kuang, G | 1 |
| Zhang, L | 3 |
| Jiang, R | 1 |
| He, Z | 1 |
| Ye, D | 1 |
| Shen, Y | 1 |
| Jin, X | 1 |
| Chen, W | 1 |
| Gao, C | 1 |
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| Fan, J | 1 |
| Luan, J | 1 |
| Cao, Z | 1 |
| Guo, Z | 1 |
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| Ju, D | 1 |
| Mei, X | 1 |
| Stefanello, ST | 1 |
| de Carvalho, NR | 1 |
| Reis, SB | 1 |
| Soares, FAA | 1 |
| Barcelos, RP | 1 |
| James, LP | 2 |
| McGill, MR | 2 |
| Roberts, DW | 1 |
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| Jiao, FZ | 1 |
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| Shin, DG | 1 |
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| De la Puerta, R | 1 |
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| Ozturk, O | 1 |
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| Adali, Y | 1 |
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| Tsai, MS | 1 |
| Wang, YH | 1 |
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| Wang, SH | 1 |
| Kim, SY | 1 |
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| Kwak, MS | 1 |
| Lee, HS | 1 |
| Kim, ES | 1 |
| Lee, JE | 1 |
| Choi, JE | 1 |
| Diamond, B | 1 |
| Shin, JS | 1 |
| Zhao, W | 1 |
| Zeng, C | 1 |
| Jia, Q | 1 |
| Yang, X | 1 |
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| Wei, Q | 1 |
| Hua, W | 1 |
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| Shan, S | 1 |
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| Alitheen, NB | 1 |
| Hua, H | 2 |
| Ge, X | 1 |
| Wu, M | 2 |
| Chen, L | 1 |
| Yang, G | 1 |
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| Huang, S | 1 |
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| Jia, Z | 2 |
| Cha, H | 1 |
| Lee, JH | 1 |
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| Fu, CL | 1 |
| Leng, J | 1 |
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| He, YF | 1 |
| Wang, Z | 1 |
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| Xie, Y | 1 |
| Xu, Y | 2 |
| Hu, Z | 1 |
| Huang, H | 1 |
| Cheng, GY | 1 |
| Jiang, Q | 1 |
| Deng, AP | 1 |
| Zhou, Q | 1 |
| Zheng, XH | 1 |
| Li, YY | 1 |
| Sun, J | 1 |
| Li, D | 1 |
| Jing, X | 1 |
| Chen, F | 1 |
| Xu, J | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation: the NEED LESS PAIN Study"[NCT02807623] | 300 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| A Randomized, Double-blind, Placebo-controlled, Multi-site, Phase III Study to Evaluate the Safety and Efficacy of CD24Fc in COVID-19 Treatment[NCT04317040] | Phase 3 | 234 participants (Actual) | Interventional | 2020-04-24 | Completed | ||
| Omega EVAR: Use of Fish Oil to Reduce Inflammation During Endovascular Abdominal Aortic Repair.[NCT03208920] | 2 participants (Actual) | Interventional | 2016-12-31 | Completed | |||
| Randomised Controlled Trial On The Effects Of Parenteral Fish Oil Emulsion In Patients With Severe Acute Pancreatitis[NCT01745861] | Phase 2 | 44 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Oral Versus Intravenous Acetaminophen for Postoperative Pain Management After Oocyte Retrieval Procedure. A Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT04662567] | 42 participants (Actual) | Interventional | 2021-03-12 | Terminated (stopped due to It was determined that the study should not continue as the study drug, Acetaminophen, could only be mixed in a solvent that would not allow the patients to be NPO prior to procedure.) | |||
| Antagonism Research Between Antiemetics Agents (Droperidol, Dexametasone, Ondansetron) and Acetaminophen in Thyroidectomy's Post-operative Analgesia.[NCT01679093] | Phase 3 | 66 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755] | 62 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Swelling at vaccination site (NCT02807623)
Timeframe: baseline, 48-72 hours, and 21- 28 days (3 points)
| Intervention | Participants (Count of Participants) |
|---|---|
| Baseline | 0 |
| 48-72 Hours After Vaccination | 0 |
| 21-28 Days After Vaccination | 0 |
Reddening of the skin at vaccination site reported as the total number of participants with erythema over the duration of the study. (NCT02807623)
Timeframe: baseline, 48- 72 hours, 21-28 days (3 points)
| Intervention | Participants (Count of Participants) |
|---|---|
| Baseline | 0 |
| 48-72 Hours After Vaccination | 0 |
| 21-28 Days After Vaccination | 0 |
A Lactate meter was used to test the exercise group for lactate readings. Two lactate tests was performed for the exercise group at Visit 1, both pre and post Influenza vaccination. The first lactate reading was taken after the blood draw.The second lactate reading was obtained from a fingerstick from the hand opposite to the vaccination arm, ideally within 3-8 minutes after the study subject completes pushups. (NCT02807623)
Timeframe: Immediately prior to Influenza vaccine and 3-8 minutes after Influenza vaccine was administered and after push-ups were completed.
| Intervention | mmol/L (Mean) | |
|---|---|---|
| Lactate before pushups | Lactate after pushups | |
| Compound Exercise of Push-ups | 1.51 | 7.69 |
Level of Pain will be measured by validated pain scale, using a scale of 0 ( best, no pain) to 10 (worst, as bad as imaginable, completely interferes). (NCT02807623)
Timeframe: baseline, 48-72 hours and at 21-28 days ( 3 points )
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Visit 1 | Visit 2 | Visit 3 | |
| Compound Exercise of Push-ups | .14 | .19 | .13 |
| Ibuprofen | .39 | .56 | .28 |
| Placebo | .19 | .22 | .06 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 214.80 | 345.09 |
| Ibuprofen | 171.00 | 239.25 |
| Placebo | 216.75 | 343.03 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 149.22 | 232.58 |
| Ibuprofen | 177.78 | 243.13 |
| Placebo | 221.09 | 296.66 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 26.00 | 41.02 |
| Ibuprofen | 17.41 | 25.47 |
| Placebo | 26.09 | 34.09 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 32.89 | 49.07 |
| Ibuprofen | 40.16 | 47.34 |
| Placebo | 36.69 | 44.78 |
Duration of ECMO treatment (days) was calculated as: End Date of ECMO Treatment - Start Date of ECMO Treatment + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29
| Intervention | Days (Mean) |
|---|---|
| Placebo | 11.0 |
Duration of oxygen therapy (oxygen inhalation by high flow nasal cannula or mask) (days) was calculated as: End Date of high flow oxygen therapy - Start Date of high flow oxygen therapy + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29
| Intervention | Days (Mean) |
|---|---|
| CD24Fc | 13.8 |
| Placebo | 13.0 |
MV included IMV and NIV. Duration of MV (days) was calculated as: End Date of MV - Start Date of MV + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29
| Intervention | Days (Mean) |
|---|---|
| CD24Fc | 14.3 |
| Placebo | 14.3 |
Pressor administration included norepinephrine, epinephrine, vasopressin, dopamine and phenylephrine. Duration of pressor (days) was defined as: End Date of Pressor - Start Date of Pressor + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29
| Intervention | Days (Mean) |
|---|---|
| CD24Fc | 6.3 |
| Placebo | 7.9 |
Length of Hospital Stay (Days) was defined as date of discharge - date of admission + 1 and reported. Data presented below include hospitalization time prior to enrollment in the study with total duration of up to 90 days. (NCT04317040)
Timeframe: Up to 90 days
| Intervention | Days (Mean) |
|---|---|
| CD24Fc | 16.6 |
| Placebo | 18.2 |
An AE was defined as any unfavorable and unintended sign including an abnormal laboratory finding, symptom or disease associated with the use of a medical treatment or procedure, regardless of whether it is considered related to the medical treatment or procedure, that occurs during the course of the study. Per protocol, only AEs with Common Terminology Criteria for AE (CTACAE) grade ≥3 were included. The number of participants who experienced an AE were reported. (NCT04317040)
Timeframe: Up to 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| CD24Fc | 32 |
| Placebo | 35 |
RF was defined as the need for any of the following: 1) mechanical ventilation (MV), 2) ECMO, 3) NIV, or 4) high flow oxygen devices. Percentage of participants who died or had respiratory failure by Day 29 were reported. (NCT04317040)
Timeframe: Up to Day 29
| Intervention | Percentage of Participants (Number) |
|---|---|
| CD24Fc | 22.4 |
| Placebo | 28.0 |
Rate of clinical relapse was defined as the percentage of participants who had initially reached score 5 on NIAID ordinal scale for more than one day but subsequently became dependent on oxygen support for more than 1 day within 28 days from randomization after initial recovery with a total follow-up period of 29 days (Day 1 of randomization plus 28 days of follow-up). NIAID ordinal scale graded as: 1=Death; 2=Hospitalized, on IMV/ECMO; 3=Hospitalized, on NIV/high flow oxygen devices; 4= Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, do not require medical care; 7=Not hospitalized, limitation on activities and/or require home oxygen; 8=Not hospitalized, no limitations on activities. Clopper-Pearson method was used to report the 95% CI. (NCT04317040)
Timeframe: Up to Day 29
| Intervention | Percentage of Participants (Number) |
|---|---|
| CD24Fc | 4.3 |
| Placebo | 6.8 |
Time to disease progression in clinical status is defined as the time (days) for progression from NIAID score (3 or 4) to (2 or 1) or from 2 to 1 within 28 days from randomization, total follow-up period 29 days (Randomization Day 1 + 28 days follow up). NIAID ordinal scale graded as: 1=Death; 2=Hospitalized, on IMV/ECMO; 3=Hospitalized, on NIV/high flow oxygen devices; 4= Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, do not require medical care; 7=Not Hospitalized, limitation on activities and/or require home oxygen; 8=Not hospitalized, no limitations on activities. (NCT04317040)
Timeframe: Up to Day 29
| Intervention | Days (Median) |
|---|---|
| CD24Fc | NA |
| Placebo | NA |
The hospital discharge time was defined as the time from randomization to discharge from the hospital and reported. Time to Hospital Discharge (days) from randomization is calculated as: Time to hospital discharge = Date of hospital discharge - Date of randomization. (NCT04317040)
Timeframe: Up to Day 29
| Intervention | Days (Median) |
|---|---|
| CD24Fc | 7.0 |
| Placebo | 10.5 |
Time to improvement in COVID-19 clinical status: defined as time (days) required from start of treatment to improvement of clinical status severe - moderate/mild or improvement from score 2-4 to ≥5 sustained without drop below 5 within 28 days from randomization, total follow-up period 29 days (Randomization Day 1 + 28 days follow up) per National Institute of Allergy & Infectious Diseases (NIAID) ordinal scale graded: 1=Death; 2=Hospitalized, on invasive mechanical ventilation (IMV)/extracorporeal membrane oxygenation (ECMO); 3=Hospitalized, on non-invasive ventilation (NIV)/high flow oxygen devices; 4=Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, don't require medical care; 7=Not hospitalized, limitation on activities &/or require home oxygen; 8=Not hospitalized, no limitations on activities. Median time & 95% confidence intervals (CIs) were reported using Brookmeyer-Crowley method. (NCT04317040)
Timeframe: Up to Day 29
| Intervention | Days (Median) |
|---|---|
| CD24Fc | 6.0 |
| Placebo | 10.5 |
Blood samples were collected to present the change from baseline in the absolute lymphocyte count on days 1, 4, 8, and 15 in peripheral blood. To calculate the change from baseline in absolute lymphocyte count at specific timepoints (Days 1, 4, 8 and 15), only the participants who had both, a baseline, and a post baseline value at the specific timepoint (Days 1, 4, 8 and 15) were included in the analysis. (NCT04317040)
Timeframe: Baseline and up to Day 15
| Intervention | 10^9 Cells/Liter (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | Day 1 | Day 4 | Day 8 | Day 15 | Change from Baseline to Day 1 | Change from Baseline to Day 4 | Change from Baseline to Day 8 | Change from Baseline to Day 15 | |
| CD24Fc | 2.357 | 5.317 | 2.373 | 2.557 | 1.965 | 0.374 | 0.219 | 0.575 | 0.558 |
| Placebo | 2.437 | 5.125 | 2.461 | 1.839 | 2.378 | -0.148 | 0.053 | -0.491 | -0.280 |
Blood samples were collected to present the change from baseline in the D-dimer concentration on days 4, 8 and 15 in peripheral blood. To calculate change from baseline in D-dimer concentration at specific timepoints (Days 4, 8 and 15), only the participants who had both, a baseline, and a post baseline value at the specific timepoint (Days 4, 8 and 15) were included in the analysis. (NCT04317040)
Timeframe: Baseline and up to Day 15
| Intervention | nmol/Liter (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| Baseline | Day 4 | Day 8 | Day 15 | Change from Baseline to Day 4 | Change from Baseline to Day 8 | Change from Baseline to Day 15 | |
| CD24Fc | 153.717 | 10.451 | 13.224 | 11.700 | -0.427 | -397.547 | 3.076 |
| Placebo | 9.767 | 13.885 | 13.349 | 13.892 | 3.971 | 0.703 | -3.591 |
Conversion rate of COVID-19 clinical status on days 8 and 15 was defined as the percentage of participants who changed from NIAID ordinal score 2, 3, 4 to score 5 or higher and reported. NIAID ordinal scale graded as: 1=Death; 2=Hospitalized, on IMV/ECMO; 3=Hospitalized, on NIV/high flow oxygen devices; 4= Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, do not require medical care; 7=Not hospitalized, limitation on activities and/or require home oxygen; 8=Not hospitalized, no limitations on activities. (NCT04317040)
Timeframe: Up to Day 15
| Intervention | Percentage of participants (Number) | |
|---|---|---|
| Day 8 | Day 15 | |
| CD24Fc | 55.2 | 71.6 |
| Placebo | 42.4 | 55.9 |
Number of participants who died due to any cause were assessed per protocol on Day 15 and Day 29. (NCT04317040)
Timeframe: Up to Day 29
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Day 15 | Day 29 | |
| CD24Fc | 11 | 16 |
| Placebo | 8 | 18 |
27 reviews available for acetaminophen and Inflammation
| Article | Year |
|---|---|
Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chemical a | 2022 |
Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis.
Topics: Acetaminophen; Cartilage, Articular; Humans; Inflammation; Macrophages; Osteoarthritis | 2023 |
Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemokines; Cytokines; DNA Fragmenta | 2020 |
Acetaminophen Oxidation and Inflammatory Markers - A Review of Hepatic Molecular Mechanisms and Preclinical Studies.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; Inflammation; Ox | 2020 |
Advances in biomarker development in acetaminophen toxicity.
Topics: Acetaminophen; Animals; Biomarkers; Cell Death; Humans; Inflammation; Liver; Mitochondria | 2020 |
The Role of Hypoxia-Induced Mitogenic Factor in Organ-Specific Inflammation in the Lung and Liver: Key Concepts and Gaps in Knowledge Regarding Molecular Mechanisms of Acute or Immune-Mediated Liver Injury.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; Humans; Inflamm | 2021 |
The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspartame; Autistic Disorder; Child; Child, Preschool; Fema | 2017 |
Autophagy and acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Autophagy; Chemical and Drug Induced Liver Injury; | 2018 |
The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxyg | 2013 |
Paracetamol (acetaminophen): a blessing or a hidden curse?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Humans; Inflammation | 2014 |
[Paracetamol-codeine, an always actual choice for the treatment of pain].
Topics: Acetaminophen; Activation, Metabolic; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; | 2014 |
Acute Nonspecific Mesenteric Lymphadenitis: More Than "No Need for Surgery".
Topics: Abdomen; Acetaminophen; Acute Disease; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Appendic | 2017 |
Inflammation and shoulder pain--a perspective on rotator cuff disease, adhesive capsulitis, and osteoarthritis: conservative treatment.
Topics: Acetaminophen; Administration, Oral; Adrenal Cortex Hormones; Analgesics, Opioid; Animals; Anti-Infl | 2009 |
Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity.
Topics: Acetaminophen; Animals; Autoimmunity; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; I | 2012 |
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Apoptosis; Cell Death; Chemical and Drug Indu | 2012 |
[Paracetamol in the treatment of osteoarthritis pain].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg | 2003 |
[Treatment for inflammation related pain--COX-2 inhibitors knocking on the door].
Topics: Acetaminophen; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; Ibupr | 2004 |
NF-kappaB, macrophage migration inhibitory factor and cyclooxygenase-inhibitions as likely mechanisms behind the acetaminophen- and NSAID-prevention of the ovarian cancer.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Cyclooxygenase 2; C | 2004 |
Nitric oxide and inflammation.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Drug Evaluation | 2006 |
Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; DNA Fragme | 2005 |
Chronic recurrent multifocal osteomyelitis presenting as acute scoliosis: a case report and review of literature.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Biopsy; Child; Chronic Disease; F | 2008 |
Role of neutrophils in the pathogenesis of acute inflammatory liver injury.
Topics: Acetaminophen; Acute Disease; Animals; Cell Adhesion; Cell Movement; Hepatitis, Alcoholic; Humans; I | 2007 |
Cyclic nitroxides inhibit the toxicity of nitric oxide-derived oxidants: mechanisms and implications.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2008 |
Etiologies of acute liver failure.
Topics: Acetaminophen; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroi | 2008 |
Evolution of ideas on the role of prostaglandins in inflammation.
Topics: Acetaminophen; Animals; Arachidonic Acids; Biological Evolution; Butylated Hydroxytoluene; Chlorprom | 1980 |
Clinical evidence for osteoarthritis as an inflammatory disease.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Combinations; Humans | 2001 |
Reduction of postembolization syndrome after ablation of renal angiomyolipoma.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Angiography; Angiomyolipoma; Catheter Ablation; Drug | 2002 |
15 trials available for acetaminophen and Inflammation
| Article | Year |
|---|---|
Inflammatory biomarkers in very preterm infants during early intravenous paracetamol administration.
Topics: Acetaminophen; Administration, Intravenous; Biomarkers; Ductus Arteriosus, Patent; Humans; Infant, N | 2021 |
Effect of low-dose dexketoprofen trometamol and paracetamol on postoperative complications after impacted third molar surgery on healthy volunteers: A pilot study.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2014 |
Periapical Microsurgery: The Effects of Locally Injected Dexamethasone on Pain, Swelling, Bruising, and Wound Healing.
Topics: Acetaminophen; Adrenal Cortex Hormones; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthe | 2016 |
Prophylactic use of acetaminophen in children vaccinated with diphtheria-tetanus-pertussis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anorexia; Chemoprevention; Diphtheria-Tetanus-Pertussis Vac | 2008 |
A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cross-Over | 2011 |
Ibuprofen and acetaminophen: effect on muscle inflammation after eccentric exercise.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non- | 2003 |
Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Cyclooxygenase 2; Dinoprostone; Female; | 2007 |
Comparative analgesic efficacies of aspirin and acetaminophen.
Topics: Acetaminophen; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Inflamma | 1981 |
A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Fever; Huma | 1993 |
An assessment of the efficacy and tolerability of nimesulide vs paracetamol in children after adenotonsillectomy.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Humans; Inf | 1993 |
Acute postoperative swelling after hand surgery: an exploratory, double-blind, randomised study with paracetamol, naproxen, and placebo.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N | 2001 |
Paracetamol versus placebo: effects on post-operative course.
Topics: Acetaminophen; Adult; Body Temperature; Clinical Trials as Topic; Double-Blind Method; Female; Human | 1979 |
[Clinical efficiency of the anti-inflammatory anesthetic combination suxibuzone-N.A.P.A].
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents; Arthritis; Capsules; Clinical Trials as Topic; | 1976 |
The effects of indoprofen vs paracetamol on swelling, pain and other events after surgery.
Topics: Acetaminophen; Adolescent; Adult; Clinical Trials as Topic; Female; Hemorrhage; Humans; Indoprofen; | 1986 |
Isotopic indices as a measure of inflammation in rheumatoid arthritis.
Topics: Acetaminophen; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Indium; | 1974 |
171 other studies available for acetaminophen and Inflammation
| Article | Year |
|---|---|
Synthesis and anti-inflammatory activity of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its ester derivatives.
Topics: Animals; Anti-Inflammatory Agents; Diterpenes; Esters; Inflammation; Magnetic Resonance Spectroscopy | 2007 |
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Participation of the descending noradrenergic inhibitory system in the anti-hyperalgesic effect of acetaminophen in a rat model of inflammation.
Topics: Acetaminophen; Animals; Carrageenan; Disease Models, Animal; Hyperalgesia; Inflammation; Locus Coeru | 2021 |
Acetaminophen-Induced Liver Injury Exposes Murine IL-22 as Sex-Related Gene Product.
Topics: Acetaminophen; Adaptive Immunity; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line, | 2021 |
Deletion of p38γ attenuates ethanol consumption- and acetaminophen-induced liver injury in mice through promoting Dlg1.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2022 |
Isobolographic analysis of antinociceptive effect of ketorolac, indomethacin, and paracetamol after simultaneous peripheral local and systemic administration.
Topics: Acetaminophen; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Dr | 2022 |
Kahweol Protects against Acetaminophen-Induced Hepatotoxicity in Mice through Inhibiting Oxidative Stress, Hepatocyte Death, and Inflammation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Hepatocytes; Inflammatio | 2022 |
Sinapic acid ameliorates paracetamol-induced acute liver injury through targeting oxidative stress and inflammation.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Inju | 2022 |
Ethnopharmacological impact of Melaleuca rugulosa (Link) Craven leaves extract on liver inflammation.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Inju | 2022 |
Hepatic SIRT6 Modulates Transcriptional Activities of FXR to Alleviate Acetaminophen-induced Hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Inflammation; Mice; Mic | 2022 |
Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury by promoting Parkin-dependent autophagy.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease.
Topics: Acetaminophen; Acetylcholine; Animals; Hydroxyproline; Hypoxia; Inflammation; Intercellular Adhesion | 2022 |
FGL2-MCOLN3-Autophagy Axis-Triggered Neutrophil Extracellular Traps Exacerbate Liver Injury in Fulminant Viral Hepatitis.
Topics: Acetaminophen; Animals; Autophagy; Calcium; Deoxyribonucleases; Disease Models, Animal; Extracellula | 2022 |
Interleukin-1β-induced inflammation and acetaminophen during infancy: Distinct and interactive effects on social-emotional and repetitive behavior in C57BL/6J mice.
Topics: Acetaminophen; Animals; Cytokines; Female; Inflammation; Interleukin-1beta; Liver; Male; Mice; Mice, | 2022 |
Ocular penetration of oral acetaminophen in horses.
Topics: Acetaminophen; Animals; Horse Diseases; Horses; Inflammation | 2023 |
Ocular penetration of oral acetaminophen in horses.
Topics: Acetaminophen; Animals; Horse Diseases; Horses; Inflammation | 2023 |
Ocular penetration of oral acetaminophen in horses.
Topics: Acetaminophen; Animals; Horse Diseases; Horses; Inflammation | 2023 |
Ocular penetration of oral acetaminophen in horses.
Topics: Acetaminophen; Animals; Horse Diseases; Horses; Inflammation | 2023 |
Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease.
Topics: Acetaminophen; Animals; Caveolin 1; Chemical and Drug Induced Liver Injury; Inflammation; Liver; Mal | 2023 |
Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Homeodomain Proteins; Inflammation; | 2023 |
Scavenger receptor a is a major homeostatic regulator that restrains drug-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Halothane; Hepatocytes; Homeostasis; | 2023 |
The analysis of reason for the presence and treatment of chronic inflammation of the paranasal sinuses in own material.
Topics: Acetaminophen; Animals; Cats; Dipyrone; Dogs; Female; Humans; Ibuprofen; Inflammation; Paranasal Sin | 2023 |
Confusoside from
Topics: Acetaminophen; Caspase 3; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Humans; Inflammation | 2023 |
Pectolinarigenin ameliorates acetaminophen-induced acute liver injury via attenuating oxidative stress and inflammatory response in Nrf2 and PPARa dependent manners.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Glutathione; Humans; Inflammation; Liver; NF- | 2023 |
Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Hepatic C-X-C chemokine receptor type 6-expressing innate lymphocytes limit detrimental myeloid hyperactivation in acute liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation; Interleukin-17; Killer | 2023 |
Bifidobacterium longum R0175 protects mice against APAP-induced liver injury by modulating the Nrf2 pathway.
Topics: Acetaminophen; Animals; Bifidobacterium longum; Chemical and Drug Induced Liver Injury; Chemical and | 2023 |
MicroRNA-29a-3p Prevents Drug-Induced Acute Liver Failure through Inflammation-Related Pyroptosis Inhibition.
Topics: Acetaminophen; Animals; Humans; Inflammation; Leukocytes, Mononuclear; Liver Failure, Acute; Mice; M | 2023 |
Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K/AKT signaling pathway in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation; Liver; Mice; Molecular | 2023 |
Mn
Topics: Acetaminophen; Animals; Antioxidants; Inflammation; Liver; Mice; Mice, Inbred C57BL; Oxidative Stres | 2024 |
Veronica persica ameliorates acetaminophen-induced murine hepatotoxicity via attenuating oxidative stress and inflammation.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Antioxidants; Chemical and Drug Induced Liver | 2023 |
CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization.
Topics: Acetaminophen; Animals; Cell Polarity; Chemical and Drug Induced Liver Injury; Chemokine CCL5; Disea | 2020 |
Towards an Effective and Safe Treatment of Inflammatory Pain: A Delphi-Guided Expert Consensus.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Consensus; Health Knowledge, Att | 2019 |
Liver-specific Bid silencing inhibits APAP-induced cell death in mice.
Topics: Acetaminophen; Animals; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist | 2019 |
Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL.
Topics: Acetaminophen; Acetylcysteine; Animals; Apoptosis; Cell Line; Chemical and Drug Induced Liver Injury | 2020 |
Comparative study on hepatoprotection of pine nut (Pinus koraiensis Sieb. et Zucc.) polysaccharide against different types of chemical-induced liver injury models in vivo.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Infective Agents, Local | 2020 |
Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver In | 2020 |
Activation of Farnesoid X Receptor by Schaftoside Ameliorates Acetaminophen-Induced Hepatotoxicity by Modulating Oxidative Stress and Inflammation.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glycosides; Inflammati | 2020 |
Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Coculture | 2020 |
Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression.
Topics: Acetaminophen; Animals; Apoptosis; Cell Death; Cell Line; Chemical and Drug Induced Liver Injury; Do | 2020 |
Interleukin-22 ameliorated acetaminophen-induced kidney injury by inhibiting mitochondrial dysfunction and inflammatory responses.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Cell Line; Cell Survival; Cytokines; Humans; Inflammaso | 2020 |
Sinomenine Attenuates Acetaminophen-Induced Acute Liver Injury by Decreasing Oxidative Stress and Inflammatory Response via Regulating TGF-β/Smad Pathway in vitro and in vivo.
Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dose-Res | 2020 |
Synergistic Antinociceptive Activity of Tramadol/Acetaminophen Combination Mediated by μ-Opioid Receptors.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Drug Synergism; Drug Therapy, | 2020 |
Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain.
Topics: Acetaminophen; Animals; Blood-Brain Barrier; Brain; Female; Gene Expression; Inflammation; Permeabil | 2020 |
Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain.
Topics: Acetaminophen; Animals; Blood-Brain Barrier; Brain; Female; Gene Expression; Inflammation; Permeabil | 2020 |
Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain.
Topics: Acetaminophen; Animals; Blood-Brain Barrier; Brain; Female; Gene Expression; Inflammation; Permeabil | 2020 |
Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain.
Topics: Acetaminophen; Animals; Blood-Brain Barrier; Brain; Female; Gene Expression; Inflammation; Permeabil | 2020 |
Orostachys japonicus ameliorates acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Crassulaceae; Dose-Response Relation | 2021 |
Tetrahydroxy stilbene glycoside attenuates acetaminophen-induced hepatotoxicity by UHPLC-Q-TOF/MS-based metabolomics and multivariate data analysis.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cytokines; Data Analysis; Discriminant | 2021 |
Protective effect of Que Zui tea hot-water and aqueous ethanol extract against acetaminophen-induced liver injury in mice via inhibition of oxidative stress, inflammation, and apoptosis.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; In | 2021 |
Acute liver injury following acetaminophen administration does not activate atrophic pathways in the mouse diaphragm.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2021 |
Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress.
Topics: Acetaminophen; Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Inflammation; L-La | 2021 |
Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Chemical and Drug Induced | 2021 |
Hepatoprotective potential of Phyllanthus muellarianus leaf extract: studies on hepatic, oxidative stress and inflammatory biomarkers.
Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Li | 2017 |
CXCL16 deficiency attenuates acetaminophen-induced hepatotoxicity through decreasing hepatic oxidative stress and inflammation in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chemokine | 2017 |
Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Inflammation | 2018 |
Suppressive effect of kamebakaurin on acetaminophen-induced hepatotoxicity by inhibiting lipid peroxidation and inflammatory response in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2017 |
Mechanisms of sterile inflammation in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation; Macrophages; Mice | 2018 |
Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia.
Topics: Acetaminophen; Analgesics; Animals; Arthritis; Celecoxib; Disease Models, Animal; Diterpenes; Female | 2017 |
The impact of vitamin C on the relationship among inflammation, lipid peroxidation and platelet activation during analgesic nephropathy in rats.
Topics: Acetaminophen; Analgesics; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Cytokines; Dinoprost; I | 2017 |
IL-33 signalling in liver immune cells enhances drug-induced liver injury and inflammation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bone Marrow Transplantation; Chemical and Drug Ind | 2018 |
NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.
Topics: Acetaminophen; Alarmins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cytokines; Huma | 2017 |
The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Amin | 2017 |
SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress.
Topics: Acetaminophen; Animals; Cell Death; Cells, Cultured; Humans; Inflammation; Liver; Macrophages; Male; | 2018 |
IL-1α in acetaminophen toxicity: a sterile danger signal.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation; Interleukin-1alpha; Ma | 2018 |
Effect of early natal supplementation of paracetamol on attenuation of exotoxin/endotoxin induced pyrexia and precipitation of autistic like features in albino rats.
Topics: Acetaminophen; Animals; Animals, Newborn; Antipyretics; Autistic Disorder; Behavior, Animal; Diphthe | 2018 |
Ginger rhizome enhances the anti-inflammatory and anti-nociceptive effects of paracetamol in an experimental mouse model of fibromyalgia.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Chronic Pain; Disease Models, Animal; Drug Synergi | 2018 |
The beneficial effects of ozone therapy in acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2018 |
Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice.
Topics: Acetaminophen; Acetylcysteine; Acute Lung Injury; Animals; Apoptosis; Cytochrome P-450 CYP2E1; DNA D | 2018 |
High-Mobility Group Box 1-Induced Complement Activation Causes Sterile Inflammation.
Topics: Acetaminophen; Animals; Antibodies, Neutralizing; Biomarkers; Cell Line; Chemical and Drug Induced L | 2018 |
Effects of the Kunlun snow chrysanthemum polysaccharides on acetaminophen-induced oxidative stress, inflammation and apoptosis using animal model.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Chrysanthemum; Dose-Respo | 2018 |
Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Berberine; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Inflam | 2018 |
Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.
Topics: Acetaminophen; Acetic Acid; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cocos; In | 2018 |
Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation.
Topics: Acetaminophen; Acute Kidney Injury; Animals; Electron Transport Complex I; Inflammation; Mice; Oxida | 2018 |
Protective effects of p-coumaric acid against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; | 2018 |
Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; | 2018 |
Protective effect of
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Catechin; Chemical and Drug Induced Liver Injury; I | 2020 |
CD31 induces inflammatory response by promoting hepatic inflammatory response and cell apoptosis.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Inflammation; | 2018 |
Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical | 2019 |
Protection of mouse brain from paracetamol-induced stress by Centella asiatica methanol extract.
Topics: Acetaminophen; Animals; Astrocytes; Behavior, Animal; Brain; Cells, Cultured; Centella; Disease Mode | 2019 |
Biological activity of Echinops spinosus on inhibition of paracetamol-induced renal inflammation.
Topics: Acetaminophen; Animals; Echinops Plant; Inflammation; Kidney; Kidney Diseases; Male; Plant Extracts; | 2019 |
HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced | 2019 |
Circulating Peroxiredoxin-1 is a novel damage-associated molecular pattern and aggravates acute liver injury via promoting inflammation.
Topics: Acetaminophen; Adult; Alarmins; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cy | 2019 |
Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, | 2019 |
Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Coculture Techniques; Cytokines; Gene Expression Regulation | 2019 |
The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Benzamides; Cell Death; Chemical and Drug Induced L | 2019 |
Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling.
Topics: Acetaminophen; Alkenes; Animals; Anti-Inflammatory Agents; Apoptosis; Chemical and Drug Induced Live | 2019 |
Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids.
Topics: Acetaminophen; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Drug Evaluation, Prec | 2019 |
Role of toll-like receptor 4 in mediating multiorgan dysfunction in mice with acetaminophen induced acute liver failure.
Topics: Acetaminophen; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Cytokines; D | 2013 |
The relationship between N-acetylcysteine, hyperbaric oxygen, and inflammation in a rat model of acetaminophen-induced nephrotoxicity.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Creatinine; F | 2013 |
Roles of lipoxin A4 in preventing paracetamol-induced acute hepatic injury in a rabbit model.
Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Chemical | 2013 |
Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Celecoxib; Dr | 2013 |
Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Ceftriaxone; Ce | 2014 |
Interleukin-4 deficiency protects mice from acetaminophen-induced liver injury and inflammation by prevention of glutathione depletion.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemokine CXCL1; Glutathione; Inflam | 2014 |
Metabolic syndrome-induced tubulointerstitial injury: role of oxidative stress and preventive effects of acetaminophen.
Topics: Acetaminophen; Actins; Analgesics, Non-Narcotic; Animals; Apoptosis; bcl-2-Associated X Protein; Cas | 2013 |
The impact of nonsteroidal anti-inflammatory drugs on inflammatory response after aneurysmal subarachnoid hemorrhage.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; C-Rea | 2014 |
Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Case-Cont | 2014 |
5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Arachidonate 5-Lipoxygenase; | 2013 |
Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chromatography, High Pressure L | 2015 |
Baccharis trimera improves the antioxidant defense system and inhibits iNOS and NADPH oxidase expression in a rat model of inflammation.
Topics: Acetaminophen; Animals; Baccharis; Cells, Cultured; Enzyme Activation; Immunity, Innate; Inflammatio | 2013 |
Association between recent acetaminophen use and asthma: modification by polymorphism at TLR4.
Topics: Acetaminophen; Adolescent; Asthma; Bronchial Hyperreactivity; Child; Cross-Sectional Studies; Eosino | 2014 |
Amelioration of paracetamol-induced hepatotoxicity in rat by the administration of methanol extract of Muntingia calabura L. leaves.
Topics: Acetaminophen; Active Transport, Cell Nucleus; AMP-Activated Protein Kinases; Animals; Cell Nucleus; | 2014 |
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Topics: Acetaminophen; Animals; Apoptosis; Autophagy; Chemical and Drug Induced Liver Injury; Fruit; Inflamm | 2014 |
Pharmacology: inflammatory definitions.
Topics: Acetaminophen; Anti-Inflammatory Agents; Humans; Inflammation; Terminology as Topic; Toothache | 2014 |
Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses.
Topics: Acetaminophen; Adenosine Triphosphate; Animals; Cell Death; Cells, Cultured; Chemical and Drug Induc | 2014 |
Bazhen decoction protects against acetaminophen induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice.
Topics: Acetaminophen; Animals; Apoptosis; Drugs, Chinese Herbal; Inflammation; Liver; Male; Mice; Oxidative | 2014 |
Supra-spinal FAAH is required for the analgesic action of paracetamol in an inflammatory context.
Topics: Acetaminophen; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Brain; Carrageenan; Hyperalgesia; | 2015 |
Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring.
Topics: Acetaminophen; Adult; Adult Children; Analgesics, Non-Narcotic; Animals; Asthma; Chemical and Drug I | 2015 |
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; fas Recept | 2015 |
Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; A | 2015 |
Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine.
Topics: Acetaminophen; Alanine Transaminase; Animals; Cannabidiol; Cocaine; Inflammation; Liver; Male; Mice; | 2015 |
Effect of Conditioned Medium and Bone Marrow Stem Cell Lysate on the Course of Acetaminophen-Induced Liver Failure.
Topics: Acetaminophen; Animals; Bone Marrow Cells; Cell Extracts; Culture Media, Conditioned; Inflammation; | 2015 |
The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Che | 2015 |
Morin mitigates acetaminophen-induced liver injury by potentiating Nrf2 regulated survival mechanism through molecular intervention in PHLPP2-Akt-Gsk3β axis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2015 |
Inflammation and depression: combined use of selective serotonin reuptake inhibitors and NSAIDs or paracetamol and psychiatric outcomes.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Ap | 2016 |
PGE2 induced in and released by dying cells functions as an inhibitory DAMP.
Topics: Acetaminophen; Alarmins; Animals; Cell Death; Cell Line, Tumor; Chemical and Drug Induced Liver Inju | 2016 |
Time-course changes in the expression levels of miR-122, -155, and -21 as markers of liver cell damage, inflammation, and regeneration in acetaminophen-induced liver injury in rats.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Gene Expression Profilin | 2016 |
A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antibodies, Neutralizing; Antipyretics; Chemical a | 2016 |
Development of microparticles for oral administration of the non-conventional radical scavenger IAC and testing in an inflammatory rat model.
Topics: Acetaminophen; Administration, Oral; Animals; Disease Models, Animal; Free Radical Scavengers; Glyce | 2016 |
Therapeutic potential of carfilzomib, an irreversible proteasome inhibitor, against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Cyclooxygenase 2; Gene Expression Regulation; Glutathione; Inflammation; Inj | 2017 |
Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Carrier Proteins; Cell Line, Tumor; Disease | 2017 |
Focal inflammatory myositis of the paraspinal neck muscles.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, | 2008 |
Anti-inflammatory and anti-pyretic activities of earthworm extract-Lampito mauritii (Kinberg).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Disease Models, Animal; | 2009 |
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Aspirin; Carrier Proteins; Caspase Inhi | 2009 |
DAMPs ramp up drug toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Immunity, Innate; Inflammation; Liver; Mice; Signa | 2009 |
CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.
Topics: Acetaminophen; Animals; CD24 Antigen; Cytokines; Dendritic Cells; HMGB1 Protein; HSP70 Heat-Shock Pr | 2009 |
Dietary catechol causes increased oxidative DNA damage in the livers of mice treated with acetaminophen.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetaminophen; Alanine Transaminase; Animals; Catechols; Chemical and D | 2009 |
Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Cucurbitacea | 2009 |
Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Cytokines; Dose-Response Relationship, Drug; Female; Glutathione; Inflammati | 2010 |
Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cerebral Cortex; Cerebrovascular Circulation; Dise | 2010 |
Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Antioxidants; Caveolin 1; Cell Proliferation; Chemokine CCL2; Inflammation; | 2010 |
CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.
Topics: Acetaminophen; Animals; Cell Differentiation; Cell Lineage; Cell Movement; Cell Proliferation; Hemat | 2010 |
N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Azoxymethane; Brain Edema; Carcinogens; Cytoki | 2010 |
Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Carrier Proteins; Caspase 1; Chemical and Drug Induced | 2011 |
Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.
Topics: Acetaminophen; Animals; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; Endotoxins; Fa | 2011 |
Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Catalase; Electrophoresis, Agar Gel; Gl | 2012 |
Effects of non-steroidal antiinflammatory drugs on D-serine-induced oxidative stress in vitro.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Inflammation; Lipid Peroxida | 2012 |
Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Behavior, A | 2012 |
Fully biodegradable and cationic poly(amino oxalate) particles for the treatment of acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Acute Disease; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cytosol; D | 2012 |
Paracetamol does not compromise early wound repair in the intestine or abdominal wall in the rat.
Topics: Abdominal Injuries; Acetaminophen; Analgesics, Non-Narcotic; Anastomosis, Surgical; Animals; Biomech | 2012 |
Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli.
Topics: Acetaminophen; Animals; Arginase; beta Catenin; Cells, Cultured; Coculture Techniques; Endothelial C | 2013 |
Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Brain; Cell Proliferation; Cytokines; G | 2012 |
A BIOCHEMICAL DISTINCTION BETWEEN NON-STEROID ANTI-INFLAMMATORY AND ANALGESIC DRUGS.
Topics: Acetaminophen; Acetanilides; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Ag | 1963 |
Pain reliever gets buff.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Inflammation; Pain Manag | 2003 |
Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Attention; Behavior, Animal; | 2004 |
Nonsteroidal anti-inflammatory drugs and acetaminophen in the treatment of an acute muscle injury.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Stero | 2004 |
Transcriptional profiling of the left and median liver lobes of male f344/n rats following exposure to acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Gene Expression | 2005 |
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and | 2006 |
Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipsychotic Agents; Carcinogens; Cell Separation | 2006 |
Effect of aspirin, paracetamol and their nitric oxide donating derivatives on exudate cytokine and PGE2 production in zymosan-induced air pouch inflammation in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 2007 |
Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs.
Topics: Acetaminophen; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anima | 2007 |
4'-Acetamidochalcone derivatives as potential antinociceptive agents.
Topics: Acetamides; Acetaminophen; Analgesics; Animals; Aspirin; Chalcone; Chalcones; Chromatography, Thin L | 2007 |
Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carrageenan; Dipyrone; Disease Models, Animal; Hyp | 2008 |
Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Down-Regulation; Fibrosis; Forecasting; Gli | 2008 |
Aspirin or paracetamol?
Topics: Acetaminophen; Aspirin; Humans; Inflammation | 1981 |
Aspirin or paracetamol?
Topics: Acetaminophen; Aspirin; Humans; Inflammation | 1981 |
Pharmacology of free radicals; recent views on their relation to inflammatory mechanisms.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Butylated Hydroxytoluene; Free Radic | 1984 |
[Hepatic lesion caused by acetaminophen. Apropos of a case with unusual portal involvement].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Inflammation; Male; Middle Aged; Necr | 1983 |
Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenin inflammation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1995 |
The dose-related effects of paracetamol on hyperalgesia and nociception in the rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Hindlimb; Inflam | 1996 |
Role of caffeine in combined analgesic drugs from the point of view of experimental pharmacology.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Edema; Indoles; | 2002 |
Effects of dipyrone on inflammatory infiltration and oxidative metabolism in gastric mucosa: comparison with acetaminophen and diclofenac.
Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, | 2002 |
Inflammation and the role of endogenous pain-producing substances.
Topics: Acetaminophen; Anti-Inflammatory Agents; Bradykinin; Histamine; Humans; Inflammation; Kallikreins; K | 1978 |
Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Carrageenan; Cyclooxygen | 1977 |
Current modalities in arthritic diseases.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Arthrit | 1987 |
Effects of paracetamol and acetylsalicylic acid on the post-operative course after experimental orthopaedic surgery in dogs.
Topics: Acetaminophen; Animals; Aspirin; Dogs; Edema; Female; Forelimb; Inflammation; Male; Pain, Postoperat | 1988 |
FS 205-397: a new antipyretic analgesic with a paracetamol-like profile of activity but lack of acute hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Infectious; Disease Mode | 1988 |
Neutrophilic eccrine hidradenitis in the absence of an underlying malignancy.
Topics: Acetaminophen; Eccrine Glands; Epithelium; Humans; Inflammation; Male; Middle Aged; Necrosis; Neutro | 1988 |
Decreased drug absorption in a patient with Behçet's syndrome.
Topics: Acetaminophen; Adult; Amitriptyline; Behcet Syndrome; Biological Availability; Diazepam; Female; Hum | 1987 |
Glycoconjugates as noninvasive probes of intrahepatic metabolism: II. Application to measurement of plasma alpha 1-acid glycoprotein turnover during inflammation.
Topics: Acetaminophen; Animals; Galactose; Glycoconjugates; Inflammation; Kinetics; Liver; Male; Orosomucoid | 1987 |
Platelet aggregation induced by arachidonic acid is accompanied by release of potential inflammatory mediators distinct from PGE2 and PGF2.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aorta; Arachidonic Acids; Aspirin; Biological Assay; Blood | 1973 |
Starch and talc emboli in drug addicts' lungs.
Topics: Acetaminophen; Adult; Alcohols; Amobarbital; Animals; Barbiturates; Female; Foreign-Body Reaction; H | 1972 |
Effects of caffeine on the absorption and analgesic efficacy of paracetamol in rats.
Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Caffeine; Depression, Chemical; Dose-Respo | 1973 |
The experimental modification of lysosomal dysfunction by anti-inflammatory drugs acting in vitro.
Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Cells, Cultured; Histamine; | 1972 |