acetaminophen has been researched along with Infections in 30 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Infections: Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen is a common therapy for fever in patients in the intensive care unit (ICU) who have probable infection, but its effects are unknown." | 9.20 | Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. ( Beasley, R; Bellomo, R; Freebairn, R; Hammond, N; Henderson, S; Holliday, M; Mackle, D; McArthur, C; McGuinness, S; Myburgh, J; Saxena, M; van Haren, F; Weatherall, M; Webb, S; Young, P, 2015) |
| "An intravenous formulation of paracetamol and an intravenous formulation of propacetamol (prodrug of paracetamol) were compared in children with acute fever due to infection in order to determine the antipyretic efficacy and safety during the 6-hour period after administration." | 9.12 | Antipyretic efficacy and safety of a single intravenous administration of 15 mg/kg paracetamol versus 30 mg/kg propacetamol in children with acute fever due to infection. ( Dalphin, ML; Duhamel, JF; Le Gall, E; Payen-Champenois, C, 2007) |
| "kg-1 acetaminophen syrup (n = 77) in 154 children (6 months to 5 years) with fever (> or = 38 degrees C) associated with infectious diseases and treated with antibiotic therapy." | 9.07 | Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics. ( Autret, E; Breart, G; Courcier, S; Goehrs, JM; Jonville, AP; Lassale, C, 1994) |
| "The present randomized single-blind trial was performed to study antipyretic effect and tolerability of alpha-methyl-4-(2-thienylcarbonyl)-phenyl acetic acid (suprofen, Suprol) suppositories versus paracetamol (acetaminophen) suppositories in pediatric patients with fever of various etiology." | 9.05 | Clinical experience and results of treatment with suprofen in pediatrics. 2nd communication: Use of suprofen suppositories as an antipyretic in children with fever due to acute infections/A single-blind controlled study of suprofen versus paracetamol. ( Michos, N; Stocker, H; Sundal, EJ; Weippl, G, 1985) |
| "Infections in early life have been linked to type 1 diabetes (T1D) risk, but no previous study has comprehensively analysed exposure to antibiotics, acetaminophen and infections during pregnancy and early childhood in relation to offspring risk of T1D." | 7.88 | Antibiotics, acetaminophen and infections during prenatal and early life in relation to type 1 diabetes. ( Joner, G; Kahrs, CR; Mårild, K; Njølstad, PR; Skrivarhaug, T; Stene, LC; Størdal, K; Tapia, G, 2018) |
| "Children frequently suffer infections accompanied by fever, which is commonly treated with acetaminophen (paracetamol), a use not devoid of risk." | 7.73 | The effects of a complex homeopathic medicine compared with acetaminophen in the symptomatic treatment of acute febrile infections in children: an observational study. ( Derasse, M; Klein, P; Weiser, M, 2005) |
| "Fever and concomitant infection, through an increment of erythrocyte glutathione depletion, sensitized the infant to the haemolytic event." | 5.37 | Acute haemolytic crisis due to concomitant presence of infection and possible altered acetaminophen catabolism in a Philipino child carrying the G6PD-Vanua Lava mutation. ( Capoluongo, E; Concolino, P; De Luca, D; Giardina, B; Maurizi, P; Minucci, A; Torti, E; Zuppi, C, 2011) |
| "No randomized study has been conducted to investigate the use of intravenous paracetamol (acetaminophen, APAP) for the management of fever due to infection." | 5.24 | Randomized, controlled, multicentre clinical trial of the antipyretic effect of intravenous paracetamol in patients admitted to hospital with infection. ( Akinosoglou, K; Giamarellos-Bourboulis, EJ; Gogos, C; Karagiannis, A; Koupetori, M; Pyrpasopoulou, A; Soumelas, GS; Sympardi, S; Tsaganos, T; Tseti, IK; Tsokos, N; Tziolos, N, 2017) |
| "Acetaminophen is a common therapy for fever in patients in the intensive care unit (ICU) who have probable infection, but its effects are unknown." | 5.20 | Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. ( Beasley, R; Bellomo, R; Freebairn, R; Hammond, N; Henderson, S; Holliday, M; Mackle, D; McArthur, C; McGuinness, S; Myburgh, J; Saxena, M; van Haren, F; Weatherall, M; Webb, S; Young, P, 2015) |
| "An intravenous formulation of paracetamol and an intravenous formulation of propacetamol (prodrug of paracetamol) were compared in children with acute fever due to infection in order to determine the antipyretic efficacy and safety during the 6-hour period after administration." | 5.12 | Antipyretic efficacy and safety of a single intravenous administration of 15 mg/kg paracetamol versus 30 mg/kg propacetamol in children with acute fever due to infection. ( Dalphin, ML; Duhamel, JF; Le Gall, E; Payen-Champenois, C, 2007) |
| "kg-1 acetaminophen syrup (n = 77) in 154 children (6 months to 5 years) with fever (> or = 38 degrees C) associated with infectious diseases and treated with antibiotic therapy." | 5.07 | Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics. ( Autret, E; Breart, G; Courcier, S; Goehrs, JM; Jonville, AP; Lassale, C, 1994) |
| "The present randomized single-blind trial was performed to study antipyretic effect and tolerability of alpha-methyl-4-(2-thienylcarbonyl)-phenyl acetic acid (suprofen, Suprol) suppositories versus paracetamol (acetaminophen) suppositories in pediatric patients with fever of various etiology." | 5.05 | Clinical experience and results of treatment with suprofen in pediatrics. 2nd communication: Use of suprofen suppositories as an antipyretic in children with fever due to acute infections/A single-blind controlled study of suprofen versus paracetamol. ( Michos, N; Stocker, H; Sundal, EJ; Weippl, G, 1985) |
| " In paediatric populations, ibuprofen and paracetamol (acetaminophen) are both commonly used over-the-counter medicines for the management of fever or mild-to-moderate pain associated with sore throat, otitis media, toothache, earache and headache." | 4.89 | Optimising the management of fever and pain in children. ( van den Anker, JN, 2013) |
| "Infections in early life have been linked to type 1 diabetes (T1D) risk, but no previous study has comprehensively analysed exposure to antibiotics, acetaminophen and infections during pregnancy and early childhood in relation to offspring risk of T1D." | 3.88 | Antibiotics, acetaminophen and infections during prenatal and early life in relation to type 1 diabetes. ( Joner, G; Kahrs, CR; Mårild, K; Njølstad, PR; Skrivarhaug, T; Stene, LC; Størdal, K; Tapia, G, 2018) |
| "Children frequently suffer infections accompanied by fever, which is commonly treated with acetaminophen (paracetamol), a use not devoid of risk." | 3.73 | The effects of a complex homeopathic medicine compared with acetaminophen in the symptomatic treatment of acute febrile infections in children: an observational study. ( Derasse, M; Klein, P; Weiser, M, 2005) |
| "Fever and concomitant infection, through an increment of erythrocyte glutathione depletion, sensitized the infant to the haemolytic event." | 1.37 | Acute haemolytic crisis due to concomitant presence of infection and possible altered acetaminophen catabolism in a Philipino child carrying the G6PD-Vanua Lava mutation. ( Capoluongo, E; Concolino, P; De Luca, D; Giardina, B; Maurizi, P; Minucci, A; Torti, E; Zuppi, C, 2011) |
| "Fever is an important mechanism of intrinsic resistance against infectious disease." | 1.37 | Fever and antipyresis in infection. ( Beasley, RW; Saxena, MK; Young, PJ, 2011) |
| "Progression of hepatic encephalopathy (HE) is a major determinant of outcome in acute liver failure (ALF)." | 1.32 | Infection and the progression of hepatic encephalopathy in acute liver failure. ( Blei, AT; Chung, C; Helenowski, I; Lee, WM; Polson, J; Reisch, J; Schiodt, FV; Vaquero, J, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.67) | 18.7374 |
| 1990's | 4 (13.33) | 18.2507 |
| 2000's | 10 (33.33) | 29.6817 |
| 2010's | 14 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tapia, G | 1 |
| Størdal, K | 1 |
| Mårild, K | 1 |
| Kahrs, CR | 1 |
| Skrivarhaug, T | 1 |
| Njølstad, PR | 1 |
| Joner, G | 1 |
| Stene, LC | 1 |
| Young, PJ | 3 |
| Weatherall, M | 3 |
| Saxena, MK | 3 |
| Bellomo, R | 3 |
| Freebairn, RC | 2 |
| Hammond, NE | 2 |
| Haren, FM | 1 |
| Henderson, SJ | 2 |
| McArthur, CJ | 2 |
| McGuinness, SP | 2 |
| Mackle, D | 3 |
| Myburgh, JA | 2 |
| Webb, SA | 2 |
| Beasley, RW | 3 |
| Giamarellos-Bourboulis, EJ | 2 |
| Spyridaki, A | 1 |
| Savva, A | 1 |
| Georgitsi, M | 1 |
| Tsaganos, T | 2 |
| Mouktaroudi, M | 1 |
| Raftogiannis, M | 1 |
| Antonopoulou, A | 1 |
| Papaziogas, V | 1 |
| Baziaka, F | 1 |
| Sereti, K | 1 |
| Christopoulos, P | 1 |
| Marioli, A | 1 |
| Kanni, T | 1 |
| Maravitsa, P | 1 |
| Pantelidou, I | 1 |
| Leventogiannis, K | 1 |
| Tsiaoussis, P | 1 |
| Lymberopoulou, K | 1 |
| Koutelidakis, IM | 1 |
| Bernsmeier, C | 1 |
| Antoniades, CG | 1 |
| Wendon, J | 1 |
| Young, P | 2 |
| Saxena, M | 2 |
| Freebairn, R | 1 |
| Hammond, N | 1 |
| van Haren, F | 1 |
| Holliday, M | 1 |
| Henderson, S | 1 |
| McArthur, C | 1 |
| McGuinness, S | 1 |
| Myburgh, J | 1 |
| Webb, S | 1 |
| Beasley, R | 2 |
| Patel, J | 1 |
| Arik, G | 1 |
| Şengül Ayçiçek, G | 1 |
| Ulger, Z | 1 |
| Leiner, S | 1 |
| Tseti, IK | 1 |
| Tziolos, N | 1 |
| Soumelas, GS | 1 |
| Koupetori, M | 1 |
| Pyrpasopoulou, A | 1 |
| Akinosoglou, K | 1 |
| Gogos, C | 1 |
| Tsokos, N | 1 |
| Karagiannis, A | 1 |
| Sympardi, S | 1 |
| Bach, SM | 1 |
| Holten, KB | 1 |
| Minucci, A | 1 |
| De Luca, D | 1 |
| Torti, E | 1 |
| Concolino, P | 1 |
| Maurizi, P | 1 |
| Giardina, B | 1 |
| Zuppi, C | 1 |
| Capoluongo, E | 1 |
| van den Anker, JN | 1 |
| van Haren, FM | 1 |
| Vaquero, J | 1 |
| Polson, J | 1 |
| Chung, C | 1 |
| Helenowski, I | 1 |
| Schiodt, FV | 1 |
| Reisch, J | 1 |
| Lee, WM | 1 |
| Blei, AT | 1 |
| Cohet, C | 1 |
| Cheng, S | 1 |
| MacDonald, C | 1 |
| Baker, M | 1 |
| Foliaki, S | 1 |
| Huntington, N | 1 |
| Douwes, J | 1 |
| Pearce, N | 1 |
| Rallis, E | 1 |
| Balatsouras, DG | 1 |
| Kouskoukis, C | 1 |
| Verros, C | 1 |
| Homsioglou, E | 1 |
| Derasse, M | 1 |
| Klein, P | 1 |
| Weiser, M | 1 |
| Perkins, JD | 1 |
| Baysoy, G | 1 |
| Duhamel, JF | 2 |
| Le Gall, E | 1 |
| Dalphin, ML | 1 |
| Payen-Champenois, C | 1 |
| Squires, RH | 1 |
| Guillot, M | 1 |
| Brouard, J | 1 |
| Debosque, S | 1 |
| Consten, L | 1 |
| Dresco, I | 1 |
| Perret, M | 1 |
| Rezvani, Y | 1 |
| Autret, E | 1 |
| Breart, G | 1 |
| Jonville, AP | 1 |
| Courcier, S | 1 |
| Lassale, C | 1 |
| Goehrs, JM | 1 |
| Ambühl, PM | 1 |
| Ballmer, PE | 1 |
| Krähenbühl, S | 1 |
| Bonadio, WA | 1 |
| Bellomo, T | 1 |
| Brady, W | 1 |
| Smith, D | 1 |
| Weippl, G | 1 |
| Michos, N | 1 |
| Sundal, EJ | 1 |
| Stocker, H | 1 |
| Steele, RW | 1 |
| Young, FS | 1 |
| Bass, JW | 1 |
| Shirkey, HC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Randomized, Placebo-controlled Phase IV Clinical Study of the Efficacy and Safety of a New Formulation of Paracetamol for the Management of Fever of Infectious Origin[NCT02283203] | Phase 4 | 80 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Efficacy of Bromocriptine to Reduce Body Temperature in Febrile Critically-ill Adults With Acute Neurologic Disease: an Open-label, Blinded Endpoint, Randomized Controlled Trial[NCT03496545] | Phase 1/Phase 2 | 47 participants (Actual) | Interventional | 2018-11-30 | Completed | ||
| Control of Fever in Septic Patients[NCT04227652] | 140 participants (Actual) | Interventional | 2013-09-03 | Completed | |||
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mean total body temperature burden above 37°C over 48 hours during which patient receives either control or intervention medication. (NCT03496545)
Timeframe: over 48 hours
| Intervention | Temperature in degrees Celsius (Mean) |
|---|---|
| Acetaminophen | 37.8 |
| Bromocriptine and Acetaminophen | 37.7 |
Time in minutes where the temperature is ≥ 38.3ºC during the 48 hours of control versus intervention administration. (NCT03496545)
Timeframe: 48 hours
| Intervention | Minutes (Mean) |
|---|---|
| Acetaminophen | 216 |
| Bromocriptine and Acetaminophen | 300 |
Time in minutes it took after medication administration for the temperature to reach < 37.5ºC. (NCT03496545)
Timeframe: 48 hours
| Intervention | Minutes (Mean) |
|---|---|
| Acetaminophen | 253.5 |
| Bromocriptine and Acetaminophen | 556 |
Episodes of symptomatic hypotension, including decrease in supine systolic and diastolic pressures of greater than 20mm and 10mm Hg respectively with patient reported accompanying symptoms of light headedness or dizziness and incidence of nausea and headache. (NCT03496545)
Timeframe: Nursing assessment at every shift during 48 hour study period after first drug administration
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Decrease in blood pressure | Nausea | Headache | |
| Acetaminophen | 12 | 2 | 8 |
| Bromocriptine and Acetaminophen | 17 | 3 | 12 |
3 reviews available for acetaminophen and Infections
| Article | Year |
|---|---|
Optimising the management of fever and pain in children.
Topics: Acetaminophen; Analgesics; Child; Comparative Effectiveness Research; Dose-Response Relationship, Dr | 2013 |
Acute liver failure in children.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Child; Drug-Related Side Effects a | 2008 |
[Fulminant hepatitis: pathogenesis, clinical aspects and management].
Topics: Acetaminophen; Adult; Brain Edema; Chemical and Drug Induced Liver Injury; Hemorrhage; Hepatic Encep | 1994 |
8 trials available for acetaminophen and Infections
| Article | Year |
|---|---|
Statistical analysis plan for the HEAT trial: a multicentre randomised placebo-controlled trial of intravenous paracetamol in intensive care unit patients with fever and infection.
Topics: Acetaminophen; Administration, Intravenous; Antipyretics; Clinical Trials, Phase II as Topic; Critic | 2013 |
Intravenous paracetamol as an antipyretic and analgesic medication: the significance of drug metabolism.
Topics: Abdominal Pain; Acetaminophen; Adolescent; Adult; Aged; Female; Fever; Humans; Infections; Infusions | 2014 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans; | 2015 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans; | 2015 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans; | 2015 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans; | 2015 |
Randomized, controlled, multicentre clinical trial of the antipyretic effect of intravenous paracetamol in patients admitted to hospital with infection.
Topics: Acetaminophen; Administration, Intravenous; Adult; Aged; Antipyretics; Double-Blind Method; Female; | 2017 |
Antipyretic efficacy and safety of a single intravenous administration of 15 mg/kg paracetamol versus 30 mg/kg propacetamol in children with acute fever due to infection.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Child; Child, Preschool; Double-Blind Method | 2007 |
[Antipyretic effect of tiaprofenic acid in children. Comparative study with paracetamol].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Humans; Inf | 1993 |
Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics.
Topics: Acetaminophen; Anti-Bacterial Agents; Child, Preschool; Double-Blind Method; Female; Fever; Humans; | 1994 |
Clinical experience and results of treatment with suprofen in pediatrics. 2nd communication: Use of suprofen suppositories as an antipyretic in children with fever due to acute infections/A single-blind controlled study of suprofen versus paracetamol.
Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Child; Chil | 1985 |
19 other studies available for acetaminophen and Infections
| Article | Year |
|---|---|
Antibiotics, acetaminophen and infections during prenatal and early life in relation to type 1 diabetes.
Topics: Acetaminophen; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Cohort Studies; Diabetes | 2018 |
What's new in acute liver failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bi | 2014 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Female; Fever; Humans; Infections; Male | 2016 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Female; Fever; Humans; Infections; Male | 2016 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Female; Fever; Humans; Infections; Male | 2016 |
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
Topics: Acetaminophen; Female; Fever; Humans; Infections; Male | 2016 |
Intravenous paracetamol and arterial hypotension. Especially in cases of infection or brain damage.
Topics: Acetaminophen; Brain Injuries; France; Humans; Hypotension; Infections; Injections, Intravenous; Pro | 2009 |
Guideline update: what's the best approach to acute low back pain?
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cry | 2009 |
Acute haemolytic crisis due to concomitant presence of infection and possible altered acetaminophen catabolism in a Philipino child carrying the G6PD-Vanua Lava mutation.
Topics: Acetaminophen; Child, Preschool; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Defi | 2011 |
Fever and antipyresis in infection.
Topics: Acetaminophen; Antipyretics; Fever; Humans; Immunity, Innate; Infections | 2011 |
The HEAT trial: a protocol for a multicentre randomised placebo-controlled trial of IV paracetamol in ICU patients with fever and infection.
Topics: Acetaminophen; Administration, Intravenous; Adult; Antipyretics; Clinical Trials, Phase II as Topic; | 2012 |
Infection and the progression of hepatic encephalopathy in acute liver failure.
Topics: Acetaminophen; Adult; Disease Progression; Female; Hepatic Encephalopathy; Humans; Infections; Liver | 2003 |
Infections, medication use, and the prevalence of symptoms of asthma, rhinitis, and eczema in childhood.
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Asthma; Child; Child, P | 2004 |
Drug eruptions in children with ENT infections.
Topics: Acetaminophen; Adolescent; Amoxicillin-Potassium Clavulanate Combination; Cephalosporins; Child; Chi | 2006 |
The effects of a complex homeopathic medicine compared with acetaminophen in the symptomatic treatment of acute febrile infections in children: an observational study.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analysis of Variance; Body Temperature; Chil | 2005 |
Acute liver failure in children: they really are not just small adults.
Topics: Acetaminophen; Adolescent; Autoimmune Diseases; Child; Child, Preschool; Hepatic Encephalopathy; Hum | 2006 |
Epidemiological study of constipation and other gastrointestinal symptoms in 8000 children (Acta Paediatr 2006; 95: 573-580).
Topics: Abdominal Pain; Acetaminophen; Anorexia; Child; Constipation; Humans; Infections | 2007 |
Correlating changes in body temperature with infectious outcome in febrile children who receive acetaminophen.
Topics: Acetaminophen; Administration, Oral; Age Factors; Bacteremia; Body Temperature; Child, Preschool; Fe | 1993 |
ORAL ANTIPYRETIC THERAPY. Evaluation of aspirin-acetaminophen combination.
Topics: Acetaminophen; Administration, Oral; Aspirin; Child, Preschool; Drug Combinations; Female; Fever; Hu | 1972 |