acetaminophen has been researched along with Hypothyroidism in 10 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effect of severe hypothyroidism on the pharmacokinetics and pharmacodynamics of oxazepam 15 mg given orally (n = 10) and the metabolism of paracetamol 750 mg given intravenously (n = 8) was investigated before and after treatment with levothyroxine." | 7.68 | Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism. ( Andreasen, F; Boesgaard, S; Døssing, M; Hansen, JM; Loft, S; Poulsen, HE; Sonne, J, 1990) |
| "Hypothyroidism was induced by methimazole, propylthiouracil, or surgical thyroidectomy and confirmed by elevated serum levels of TSH." | 5.30 | Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. ( Aeed, H; Avni, Y; Bruck, R; Frenkel, D; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1999) |
| " The effect of severe hypothyroidism on the pharmacokinetics and pharmacodynamics of oxazepam 15 mg given orally (n = 10) and the metabolism of paracetamol 750 mg given intravenously (n = 8) was investigated before and after treatment with levothyroxine." | 3.68 | Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism. ( Andreasen, F; Boesgaard, S; Døssing, M; Hansen, JM; Loft, S; Poulsen, HE; Sonne, J, 1990) |
| " It was a prerequisite to establish the bioavailability of oxazepam prior to succeeding studies on the oral disposition of the drug." | 2.38 | Factors and conditions affecting the glucuronidation of oxazepam. ( Sonne, J, 1993) |
| "Hypothyroidism was induced by methimazole, propylthiouracil, or surgical thyroidectomy and confirmed by elevated serum levels of TSH." | 1.30 | Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. ( Aeed, H; Avni, Y; Bruck, R; Frenkel, D; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1999) |
| " Whereas a toxic dose of acetaminophen administration did not effect SGOT and SGPT levels after 30 hr in PTU pretreated rats given either a single or multiple injections of DEM, the same dose of acetaminophen in the control rats raised these transaminases to a very high level." | 1.27 | Prevention of acetaminophen hepatotoxicity by propylthiouracil in the glutathione depleted rat. ( Cho, C; Linscheer, WG; Raheja, KL, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thynne, TR | 1 |
| Doogue, MP | 1 |
| Raheja, KL | 3 |
| Linscheer, WG | 3 |
| Cho, C | 3 |
| Mahany, D | 1 |
| Smith, NJ | 1 |
| Szabo, S | 1 |
| Forfar, JC | 1 |
| Pottage, A | 1 |
| Toft, AD | 1 |
| Irvine, WJ | 1 |
| Clements, JA | 1 |
| Prescott, LF | 1 |
| Sonne, J | 2 |
| Bruck, R | 1 |
| Frenkel, D | 1 |
| Shirin, H | 1 |
| Aeed, H | 1 |
| Matas, Z | 1 |
| Papa, M | 1 |
| Zaidel, L | 1 |
| Avni, Y | 1 |
| Oren, R | 1 |
| Halpern, Z | 1 |
| Mosby, EL | 1 |
| Hiatt, WR | 1 |
| Boesgaard, S | 1 |
| Poulsen, HE | 1 |
| Loft, S | 1 |
| Hansen, JM | 1 |
| Døssing, M | 1 |
| Andreasen, F | 1 |
1 review available for acetaminophen and Hypothyroidism
| Article | Year |
|---|---|
Factors and conditions affecting the glucuronidation of oxazepam.
Topics: Acetaminophen; Age Factors; Aged; Aged, 80 and over; Biological Availability; Biotransformation; Die | 1993 |
9 other studies available for acetaminophen and Hypothyroidism
| Article | Year |
|---|---|
A dose of paracetamol for the levothyroxine absorption test.
Topics: Absorption; Acetaminophen; Adult; Female; Humans; Hypothyroidism; Malabsorption Syndromes; Patient C | 2013 |
Prevention of acetaminophen hepatotoxicity by propylthiouracil in the glutathione depleted rat.
Topics: Acetaminophen; Animals; Free Radicals; Glutathione; Hypothyroidism; Liver; Male; Maleates; Propylthi | 1983 |
Protective effect of propylthiouracil independent of its hypothyroid effect on acetaminophen toxicity in the rat.
Topics: Acetaminophen; Animals; Glutathione; Hyperthyroidism; Hypothyroidism; Liver; Liver Glycogen; Male; P | 1982 |
Mechanism of the protective effect of propylthiouracil against acetaminophen (Tylenol) toxicity in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1980 |
Role of glutathione in the protective effect of hypothyroidism against chemically induced hepatic injury: new or old associations?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Hypothyroidism; Rats; T | 1980 |
Paracetamol pharmacokinetics in thyroid disease.
Topics: Acetaminophen; Adult; Aged; Female; Humans; Hyperthyroidism; Hypothyroidism; Kinetics; Male; Middle | 1980 |
Hypothyroidism protects rat liver from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Chemical and Drug Induced Li | 1999 |
Diagnosis of hypothyroidism after a surgical complication.
Topics: Acetaminophen; Adult; Humans; Hypothyroidism; Male; Oral Hemorrhage; Pain; Postoperative Complicatio | 1975 |
Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Female; Humans; Hypothyroidism; Infusions, Intrave | 1990 |