acetaminophen has been researched along with Hypothermia, Accidental in 28 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This preliminary trial suggests that acetaminophen-induced hypothermia is exacerbated during cold stress." | 9.24 | Acetaminophen (Paracetamol) Induces Hypothermia During Acute Cold Stress. ( Foster, J; Govus, A; Hewson, D; Mauger, AR; Taylor, L, 2017) |
| "Early administration of acetaminophen (3900 mg/d) to afebrile patients with acute stroke may result in a small reduction in CBT." | 9.10 | Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial. ( Chalela, JA; Grotta, JC; Kasner, SE; Kimmel, SE; Krieger, DW; Morgenstern, LB; Piriyawat, P; Villar-Cordova, CE; Wein, T, 2002) |
| "We report the case of a 4-month-old baby boy who presented hypothermia (rectal temperature 36°C) after acetaminophen intake for post-vaccination fever." | 9.01 | Transient major hypothermia associated with acetaminophen: A pediatric case report and literature review. ( Agier, MS; Bediou, E; Boyer Gervoise, M; Chollet, N; Jonville-Bera, AP, 2019) |
| "As an effective antipyretic with a yet-unknown mechanism-of-action, intravenous (IV) acetaminophen use for total hip arthroplasties (THA) may worsen perioperative hypothermia when combined with the known hypothermia-inducing effects of general anesthesia (GA), affecting wound healing, recovery times, and patient satisfaction." | 7.80 | Medication safety: does intravenous acetaminophen promote perioperative hypothermia for total hip arthroplasty? ( Annam, SK; Kocz, R; Toufexis, G; Visnjevac, O; Visnjevac, T, 2014) |
| "There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia." | 7.79 | Acetaminophen/diphenhydramine overdose in profound hypothermia. ( Rollstin, AD; Seifert, SA, 2013) |
| "Hypothermia is an uncommon side effect of acetaminophen." | 7.71 | [Acetaminophen-induced hypothermia, an AIDS related side-effect? About 4 cases]. ( Amaniou, M; Denes, E; Merle, L; Rogez, JP; Weinbreck, P, 2002) |
| "Pretreatment of mice with phenobarbital, an inducer of oxidative drug metabolism, had no effect on the early hypothermic effect of a toxic dose of acetaminophen, while pretreatment with metyrapone, SKF-525A, or piperonyl butoxide (inhibitors of mixed-function oxidase) enhanced the hypothermia." | 7.66 | Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound. ( Massey, TE; McElligott, TF; Racz, WJ; Walker, RM, 1982) |
| "Acetaminophen is a widely used antipyretic analgesic, reducing fever caused by bacterial and viral infections and by clinical trauma such as cancer or stroke." | 5.32 | Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein. ( Ayoub, SS; Ballou, LR; Botting, RM; Colville-Nash, PR; Goorha, S; Willoughby, DA, 2004) |
| "This preliminary trial suggests that acetaminophen-induced hypothermia is exacerbated during cold stress." | 5.24 | Acetaminophen (Paracetamol) Induces Hypothermia During Acute Cold Stress. ( Foster, J; Govus, A; Hewson, D; Mauger, AR; Taylor, L, 2017) |
| "Early administration of acetaminophen (3900 mg/d) to afebrile patients with acute stroke may result in a small reduction in CBT." | 5.10 | Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial. ( Chalela, JA; Grotta, JC; Kasner, SE; Kimmel, SE; Krieger, DW; Morgenstern, LB; Piriyawat, P; Villar-Cordova, CE; Wein, T, 2002) |
| "We report the case of a 4-month-old baby boy who presented hypothermia (rectal temperature 36°C) after acetaminophen intake for post-vaccination fever." | 5.01 | Transient major hypothermia associated with acetaminophen: A pediatric case report and literature review. ( Agier, MS; Bediou, E; Boyer Gervoise, M; Chollet, N; Jonville-Bera, AP, 2019) |
| "These studies demonstrate the direct inhibition of mitochondrial function by acetaminophen at concentrations which have been shown to reduce fever and hypothermia in mammals." | 4.31 | Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen. ( Bashir, S; Morgan, WA, 2023) |
| "The mode of action of paracetamol (acetaminophen), which is widely used for treating pain and fever, has remained obscure, but may involve several distinct mechanisms, including cyclooxygenase inhibition and transient receptor potential ankyrin 1 (TRPA1) channel activation, the latter being recently associated with paracetamol's propensity to elicit hypothermia at higher doses." | 3.88 | The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1-mediated hypothermia and is associated with prostaglandin inhibition in the brain. ( Blomgren, A; Blomqvist, A; Engblom, D; Högestätt, ED; Mirrasekhian, E; Nilsson, JLÅ; Shionoya, K; Zygmunt, PM, 2018) |
| "As an effective antipyretic with a yet-unknown mechanism-of-action, intravenous (IV) acetaminophen use for total hip arthroplasties (THA) may worsen perioperative hypothermia when combined with the known hypothermia-inducing effects of general anesthesia (GA), affecting wound healing, recovery times, and patient satisfaction." | 3.80 | Medication safety: does intravenous acetaminophen promote perioperative hypothermia for total hip arthroplasty? ( Annam, SK; Kocz, R; Toufexis, G; Visnjevac, O; Visnjevac, T, 2014) |
| "There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia." | 3.79 | Acetaminophen/diphenhydramine overdose in profound hypothermia. ( Rollstin, AD; Seifert, SA, 2013) |
| "In patients with FHF and cerebral edema from acetaminophen overdose, prolonged therapeutic hypothermia could potentially be used as a life saving therapy and a bridge to hepatic and neurological recovery." | 3.75 | Prolonged hypothermia as a bridge to recovery for cerebral edema and intracranial hypertension associated with fulminant hepatic failure. ( Jacob, S; Jacobs, ER; Kandiah, P; Khan, A; Nanchal, R, 2009) |
| "Hypothermia is an uncommon side effect of acetaminophen." | 3.71 | [Acetaminophen-induced hypothermia, an AIDS related side-effect? About 4 cases]. ( Amaniou, M; Denes, E; Merle, L; Rogez, JP; Weinbreck, P, 2002) |
| "A 1-year-old child with severe acetaminophen (APAP) poisoning after ingestion of 10 gm APAP demonstrated central nervous system depression, shock, hypothermia, and metabolic acidosis." | 3.67 | Metabolism and pharmacokinetics of acetaminophen in a severely poisoned young child. ( Fleischmann, LE; Hook, JB; Kauffman, RE; Lieh-Lai, MW; Miceli, JN; Newton, JF; Sarnaik, AP, 1984) |
| "Pretreatment of mice with phenobarbital, an inducer of oxidative drug metabolism, had no effect on the early hypothermic effect of a toxic dose of acetaminophen, while pretreatment with metyrapone, SKF-525A, or piperonyl butoxide (inhibitors of mixed-function oxidase) enhanced the hypothermia." | 3.66 | Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound. ( Massey, TE; McElligott, TF; Racz, WJ; Walker, RM, 1982) |
| "Acetaminophen (APAP) is an effective antipyretic and one of the most commonly used analgesic drugs." | 1.42 | TRPA1 mediates the hypothermic action of acetaminophen. ( Andersson, DA; Bevan, S; Gentry, C, 2015) |
| "Although fever and hypothermia are common abnormal physical signs observed in patients admitted to intensive care units (ICU), little data exist on their optimal management." | 1.39 | Diagnosis and management of temperature abnormality in ICUs: a EUROBACT investigators' survey. ( de Waele, J; Dimopoulos, G; Koulenti, D; Laupland, KB; Niven, DJ; Rello, J; Tabah, A; Timsit, JF; Vesin, A, 2013) |
| "Acetaminophen is a widely used antipyretic analgesic, reducing fever caused by bacterial and viral infections and by clinical trauma such as cancer or stroke." | 1.32 | Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein. ( Ayoub, SS; Ballou, LR; Botting, RM; Colville-Nash, PR; Goorha, S; Willoughby, DA, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (32.14) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 6 (21.43) | 29.6817 |
| 2010's | 9 (32.14) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Bashir, S | 3 |
| Morgan, WA | 3 |
| Tan, YL | 1 |
| Ho, HK | 1 |
| Foster, J | 1 |
| Mauger, AR | 1 |
| Govus, A | 1 |
| Hewson, D | 1 |
| Taylor, L | 1 |
| Mirrasekhian, E | 1 |
| Nilsson, JLÅ | 1 |
| Shionoya, K | 1 |
| Blomgren, A | 1 |
| Zygmunt, PM | 1 |
| Engblom, D | 1 |
| Högestätt, ED | 1 |
| Blomqvist, A | 1 |
| Agier, MS | 1 |
| Chollet, N | 1 |
| Bediou, E | 1 |
| Boyer Gervoise, M | 1 |
| Jonville-Bera, AP | 1 |
| Niven, DJ | 1 |
| Laupland, KB | 1 |
| Tabah, A | 1 |
| Vesin, A | 1 |
| Rello, J | 1 |
| Koulenti, D | 1 |
| Dimopoulos, G | 1 |
| de Waele, J | 1 |
| Timsit, JF | 1 |
| Visnjevac, O | 1 |
| Kocz, R | 1 |
| Visnjevac, T | 1 |
| Annam, SK | 1 |
| Toufexis, G | 1 |
| Gentry, C | 1 |
| Andersson, DA | 1 |
| Bevan, S | 1 |
| Fukushima, A | 1 |
| Sekiguchi, W | 1 |
| Mamada, K | 1 |
| Tohma, Y | 1 |
| Ono, H | 1 |
| Jacob, S | 1 |
| Khan, A | 1 |
| Jacobs, ER | 1 |
| Kandiah, P | 1 |
| Nanchal, R | 1 |
| Ayoub, SS | 2 |
| Pryce, G | 1 |
| Seed, MP | 1 |
| Bolton, C | 1 |
| Flower, RJ | 1 |
| Baker, D | 1 |
| Rollstin, AD | 1 |
| Seifert, SA | 1 |
| Denes, E | 1 |
| Amaniou, M | 1 |
| Rogez, JP | 1 |
| Weinbreck, P | 1 |
| Merle, L | 1 |
| Botting, RM | 1 |
| Goorha, S | 1 |
| Colville-Nash, PR | 1 |
| Willoughby, DA | 1 |
| Ballou, LR | 1 |
| Richardson, J | 1 |
| Sills, J | 1 |
| Lieh-Lai, MW | 1 |
| Sarnaik, AP | 1 |
| Newton, JF | 1 |
| Miceli, JN | 1 |
| Fleischmann, LE | 1 |
| Hook, JB | 1 |
| Kauffman, RE | 1 |
| MacKenzie, J | 1 |
| Lacouture, PG | 1 |
| Lovejoy, FH | 1 |
| Mitchell, AA | 1 |
| Massey, TE | 1 |
| Walker, RM | 1 |
| McElligott, TF | 1 |
| Racz, WJ | 1 |
| Block, R | 2 |
| Kasner, SE | 1 |
| Wein, T | 1 |
| Piriyawat, P | 1 |
| Villar-Cordova, CE | 1 |
| Chalela, JA | 1 |
| Krieger, DW | 1 |
| Morgenstern, LB | 1 |
| Kimmel, SE | 1 |
| Grotta, JC | 1 |
| Koennecke, HC | 1 |
| Dascombe, MJ | 1 |
| Milton, AS | 1 |
| Myers, RD | 1 |
| Jankowski, JA | 1 |
| Lacoux, P | 1 |
| Pennington, CR | 1 |
| Van Tittelboom, T | 1 |
| Govaerts-Lepicard, M | 1 |
| Wright, RC | 1 |
| Boyd, EM | 1 |
| Hogan, SE | 1 |
2 reviews available for acetaminophen and Hypothermia, Accidental
| Article | Year |
|---|---|
Transient major hypothermia associated with acetaminophen: A pediatric case report and literature review.
Topics: Acetaminophen; Antipyretics; Humans; Hypothermia; Infant; Male | 2019 |
Hypothermia: an unusual side effect of paracetamol.
Topics: Acetaminophen; Child, Preschool; Female; Humans; Hypothermia; Infant; Male | 1989 |
2 trials available for acetaminophen and Hypothermia, Accidental
| Article | Year |
|---|---|
Acetaminophen (Paracetamol) Induces Hypothermia During Acute Cold Stress.
Topics: Acetaminophen; Cold Temperature; Double-Blind Method; Heart Rate; Humans; Hypothermia; Male; Young A | 2017 |
Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial.
Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Double-Blind Method; Female; Fever; Humans; Hy | 2002 |
24 other studies available for acetaminophen and Hypothermia, Accidental
| Article | Year |
|---|---|
Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen.
Topics: Acetaminophen; Adrenergic Agents; Animals; Antipyretics; Benzoquinones; Fatty Acids; Hypothermia; Ma | 2023 |
Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen.
Topics: Acetaminophen; Adrenergic Agents; Animals; Antipyretics; Benzoquinones; Fatty Acids; Hypothermia; Ma | 2023 |
Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen.
Topics: Acetaminophen; Adrenergic Agents; Animals; Antipyretics; Benzoquinones; Fatty Acids; Hypothermia; Ma | 2023 |
Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen.
Topics: Acetaminophen; Adrenergic Agents; Animals; Antipyretics; Benzoquinones; Fatty Acids; Hypothermia; Ma | 2023 |
Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen.
Topics: Acetaminophen; Adrenergic Agents; Animals; Antipyretics; Benzoquinones; Fatty Acids; Hypothermia; Ma | 2023 |
Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen.
Topics: Acetaminophen; Adrenergic Agents; Animals; Antipyretics; Benzoquinones; Fatty Acids; Hypothermia; Ma | 2023 |
Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen.
Topics: Acetaminophen; Adrenergic Agents; Animals; Antipyretics; Benzoquinones; Fatty Acids; Hypothermia; Ma | 2023 |
Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen.
Topics: Acetaminophen; Adrenergic Agents; Animals; Antipyretics; Benzoquinones; Fatty Acids; Hypothermia; Ma | 2023 |
Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen.
Topics: Acetaminophen; Adrenergic Agents; Animals; Antipyretics; Benzoquinones; Fatty Acids; Hypothermia; Ma | 2023 |
Hypothermia Advocates Functional Mitochondria and Alleviates Oxidative Stress to Combat Acetaminophen-Induced Hepatotoxicity.
Topics: Acetaminophen; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Chemical and Drug Induced Li | 2020 |
The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1-mediated hypothermia and is associated with prostaglandin inhibition in the brain.
Topics: Acetaminophen; Animals; Antipyretics; Brain; Dinoprostone; Hypothermia; Mice; Mice, Knockout; TRPA1 | 2018 |
Diagnosis and management of temperature abnormality in ICUs: a EUROBACT investigators' survey.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Bacteremia; Clinical Protocols | 2013 |
Medication safety: does intravenous acetaminophen promote perioperative hypothermia for total hip arthroplasty?
Topics: Acetaminophen; Administration, Intravenous; Aged; Anesthesia, General; Arthroplasty, Replacement, Hi | 2014 |
TRPA1 mediates the hypothermic action of acetaminophen.
Topics: Acetaminophen; Acrolein; Animals; Antipyretics; Benzoquinones; Diterpenes; Female; Hypothermia; Hypo | 2015 |
Serotonergic System Does Not Contribute to the Hypothermic Action of Acetaminophen.
Topics: Acetaminophen; Animals; Brain; Hypothermia; Hypothermia, Induced; Male; Mice; Receptors, Serotonin; | 2017 |
Prolonged hypothermia as a bridge to recovery for cerebral edema and intracranial hypertension associated with fulminant hepatic failure.
Topics: Acetaminophen; Adult; Brain; Brain Edema; Female; Humans; Hypothermia; Hypothermia, Induced; Intracr | 2009 |
Paracetamol-induced hypothermia is independent of cannabinoids and transient receptor potential vanilloid-1 and is not mediated by AM404.
Topics: Acetaminophen; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Cannabinoids; Cinnamates; Hypo | 2011 |
Acetaminophen/diphenhydramine overdose in profound hypothermia.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2013 |
[Acetaminophen-induced hypothermia, an AIDS related side-effect? About 4 cases].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Female; HIV Infections; Humans; Hypothermia; Injecti | 2002 |
Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein.
Topics: Acetaminophen; Aminopyrine; Animals; Antipyrine; Brain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxy | 2004 |
Hypothermia following fever.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Fever; Humans; Hypothermia; Ibuprofen; Infant | 2004 |
Metabolism and pharmacokinetics of acetaminophen in a severely poisoned young child.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cystine | 1984 |
Hypothermia and hypotension in Hodgkin's disease.
Topics: Acetaminophen; Female; Hodgkin Disease; Humans; Hypotension; Hypothermia; Middle Aged | 1981 |
Acute hypothermia associated with atropine.
Topics: Acetaminophen; Adolescent; Atropine; Humans; Hypothermia; Male | 1983 |
Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound.
Topics: Acetaminophen; Animals; Hypothermia; Male; Mice; Phenobarbital; Piperonyl Butoxide; Proadifen; Time | 1982 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Adult; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Hypothermia | 1993 |
Modification of body temperature after acute stroke: a new concept needed?
Topics: Acetaminophen; Acute Disease; Body Temperature; Double-Blind Method; Fever; Humans; Hypothermia; Str | 2002 |
The effects of cyclic adenosine 3',5'-monophosphate and other adenine nucleotides on body temperature.
Topics: Acetaminophen; Acetylcholine; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; A | 1975 |
Diencephalic efflux of 22Na+ and 45Ca2+ ions in the febrile cat: effect of an antipyretic.
Topics: Acetaminophen; Animals; Calcium; Cats; Diencephalon; Female; Fever; Hypothermia; Male; Pyrogens; Sal | 1976 |
Does hypothermia protect against the development of hepatitis in paracetamol overdose?
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hypoth | 1992 |
A simple plan for the management of drug overdosage.
Topics: Absorption; Acetaminophen; Antidepressive Agents; Barbiturates; Body Fluids; Charcoal; Coma; Female; | 1974 |
The chronic oral toxicity of paracetamol at the range of the LD50 (100 days) in albino rats.
Topics: Acetaminophen; Animals; Anorexia Nervosa; Body Weight; Brain; Diuresis; Dyspnea; Growth; Humans; Hyp | 1968 |