acetaminophen has been researched along with Hypotension in 43 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intravenous acetaminophen/paracetamol (APAP) is well documented to cause hypotension." | 7.96 | Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly. ( Abbott, GW; Hayes, K; Jepps, TA; Manville, RW; Thomsen, MB; van der Horst, J, 2020) |
| "All adverse hypotension cases, regardless of suspected drug, and all ADRs associated with paracetamol and propacetamol use were collected from the Korea Adverse Event Reporting System database between 2011 and 2014." | 7.85 | Propacetamol poses a potential harm of adverse hypotension in male and older patients. ( Ban, GY; Jeong, CG; Kim, SH; Lee, HY; Lee, JH; Lee, YH; Park, SH; Ye, YM, 2017) |
| "Prazosin's increase in popularity as a treatment for posttraumatic stress disorder makes it important for emergency physicians to be aware of how to manage potential toxic ingestion because of prazosin overdose." | 6.58 | Refractory Hypotension Caused by Prazosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of the Literature. ( Anderson, C; Gupta, R; Lim, RK; Lynch, T, 2018) |
| "In May and June 2020, an open-date literature search of English publications indexed in ProQuest, PubMed, and EBSCO was conducted with the search terms 'acetaminophen' and 'hypotension' and related search combinations ('paracetamol', 'propacetamol', 'low blood pressure', 'fever', 'sepsis', and 'shock') to identify peer-reviewed publications of blood pressure changes after paracetamol administration in humans." | 5.22 | A narrative review of paracetamol-induced hypotension: Keeping the patient safe. ( Young, TL, 2022) |
| "Intravenous propacetamol is commonly used to control fever and pain in neurocritically ill patients in whom oral administration is often difficult." | 4.12 | Risk Factors for Intravenous Propacetamol-Induced Blood Pressure Drop in the Neurointensive Care Unit: A Retrospective Observational Study. ( Han, MK; Jeon, S; Jeong, HG; Lee, E; Lee, J; Lee, JY; Song, YJ, 2022) |
| "Intravenous acetaminophen/paracetamol (APAP) is well documented to cause hypotension." | 3.96 | Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly. ( Abbott, GW; Hayes, K; Jepps, TA; Manville, RW; Thomsen, MB; van der Horst, J, 2020) |
| "We retrospectively reviewed the medical records of the patients with laboratory-confirmed influenza A who received intravenous propacetamol for the control of fever in the ED during the 2015-16 influenza season." | 3.88 | Hemodynamic changes in patients with influenza A after propacetamol infusion in the emergency department. ( Durey, A; Han, SB; Kim, AJ; Lee, HJ; Suh, YJ, 2018) |
| "Male gender, chorioamnionitis, early sepsis, asphyxia, hemodynamic PDA, persistent hypotension, ibuprofen and paracetamol usage, and orogastric catheter administration were the main risk factors for gastric perforations in VLBW infants." | 3.88 | Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature. ( Babayigit, A; Cetinkaya, M; Ozaydın, S; Sander, S, 2018) |
| "Clinical studies have indicated that transient hypotension can occur after propacetamol administration." | 3.88 | Hemodynamic changes after propacetamol administration in patients with febrile UTI in the ED. ( Durey, A; Kang, S; Kim, AJ; Suh, YJ, 2018) |
| "All adverse hypotension cases, regardless of suspected drug, and all ADRs associated with paracetamol and propacetamol use were collected from the Korea Adverse Event Reporting System database between 2011 and 2014." | 3.85 | Propacetamol poses a potential harm of adverse hypotension in male and older patients. ( Ban, GY; Jeong, CG; Kim, SH; Lee, HY; Lee, JH; Lee, YH; Park, SH; Ye, YM, 2017) |
| "We sought to assess the incidence of acetaminophen-induced hypotension." | 3.83 | Acetaminophen-Induced Changes in Systemic Blood Pressure in Critically Ill Patients: Results of a Multicenter Cohort Study. ( Abroug, F; Balichard, S; Bornstain, C; Cantais, A; Darmon, M; Hammouda, Z; Meziani, F; Perinel, S; Schnell, D; Vincent, F; Zeni, F, 2016) |
| "To elucidate the mechanism of hypotension following intravenous administration of paracetamol (acetaminophen) to patients on the Intensive Care Unit." | 3.79 | Mechanism of paracetamol-induced hypotension in critically ill patients: a prospective observational cross-over study. ( Duška, F; Krajčová, A; Matoušek, V, 2013) |
| "We did not find any complications associated with the use of acetaminophen or ibuprofen in children with enteric fever." | 3.70 | Reevaluation of antipyretics in children with enteric fever. ( Fernandez, M; Kaplan, SL; Noyola, DE, 1998) |
| "We describe four cases of anaphylaxis to paracetamol without co-existing aspirin intolerance and review the Australian experience in paracetamol anaphylaxis." | 3.68 | Paracetamol anaphylaxis. ( Czarny, D; Leung, R; Plomley, R, 1992) |
| " We compared the physiological effects of intravenous mannitol-containing paracetamol, and an equivalent dosage of mannitol, and normal saline 0." | 2.82 | The haemodynamic effects of intravenous paracetamol (acetaminophen) in healthy volunteers: a double-blind, randomized, triple crossover trial. ( Bailey, M; Bellomo, R; Chiam, E; McNicol, L; Weinberg, L, 2016) |
| "Overall, pharmacokinetic data were roughly comparable with earlier publications, but differences were noted in the subgroup ICU patients." | 2.75 | Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance. ( Brüggemann, RJ; de Maat, MM; Ponssen, HH; Tijssen, TA, 2010) |
| "Prazosin's increase in popularity as a treatment for posttraumatic stress disorder makes it important for emergency physicians to be aware of how to manage potential toxic ingestion because of prazosin overdose." | 2.58 | Refractory Hypotension Caused by Prazosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of the Literature. ( Anderson, C; Gupta, R; Lim, RK; Lynch, T, 2018) |
| "Only hypotension has become less frequent as antidepressants replace barbiturates as the main cause of drug-induced coma." | 1.26 | Changing pattern of drugs used for self-poisoning. ( Park, J; Proudfoot, AT, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (9.30) | 18.7374 |
| 1990's | 4 (9.30) | 18.2507 |
| 2000's | 9 (20.93) | 29.6817 |
| 2010's | 21 (48.84) | 24.3611 |
| 2020's | 5 (11.63) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, E | 3 |
| Song, YJ | 1 |
| Jeon, S | 1 |
| Lee, J | 1 |
| Lee, JY | 1 |
| Han, MK | 1 |
| Jeong, HG | 1 |
| Isbister, GK | 1 |
| Polanski, R | 1 |
| Cooper, JM | 1 |
| Keegan, M | 1 |
| Isoardi, KZ | 1 |
| Masui, R | 1 |
| Komiya, K | 1 |
| Tanaka, A | 1 |
| Matsumoto, H | 1 |
| Yoshikawa, H | 1 |
| Ichihara, S | 1 |
| Yamanaka, M | 1 |
| Yokoyama, A | 1 |
| Hiramatsu, K | 1 |
| Kadota, JI | 1 |
| Kounis, NG | 1 |
| Koniari, I | 1 |
| Velissaris, D | 1 |
| Plotas, P | 1 |
| Tzanis, G | 1 |
| Tsigkas, G | 1 |
| Soufras, GD | 1 |
| Chourdakis, E | 1 |
| Davlouros, P | 1 |
| Hahalis, G | 1 |
| Achuff, BJ | 2 |
| Moffett, BS | 2 |
| Acosta, S | 2 |
| Lasa, JJ | 2 |
| Checchia, PA | 2 |
| Rusin, CG | 2 |
| van der Horst, J | 1 |
| Manville, RW | 1 |
| Hayes, K | 1 |
| Thomsen, MB | 1 |
| Abbott, GW | 1 |
| Jepps, TA | 1 |
| Young, TL | 1 |
| Yaman, A | 1 |
| Demir, B | 1 |
| Belen, FB | 1 |
| Filik, B | 1 |
| Güneş, N | 1 |
| Barlık, F | 1 |
| Kendirli, T | 1 |
| Lee, HJ | 1 |
| Suh, YJ | 2 |
| Kim, AJ | 2 |
| Han, SB | 1 |
| Durey, A | 2 |
| Babayigit, A | 1 |
| Ozaydın, S | 1 |
| Cetinkaya, M | 1 |
| Sander, S | 1 |
| Kang, S | 1 |
| Anderson, C | 1 |
| Lynch, T | 1 |
| Gupta, R | 1 |
| Lim, RK | 1 |
| Maxwell, EN | 1 |
| Johnson, B | 1 |
| Cammilleri, J | 1 |
| Ferreira, JA | 1 |
| Chiam, E | 1 |
| Weinberg, L | 1 |
| Bailey, M | 1 |
| McNicol, L | 1 |
| Bellomo, R | 1 |
| Bae, JI | 1 |
| Ahn, S | 1 |
| Lee, YS | 1 |
| Kim, WY | 1 |
| Lee, JH | 2 |
| Oh, BJ | 1 |
| Lim, KS | 1 |
| Cantais, A | 1 |
| Schnell, D | 1 |
| Vincent, F | 1 |
| Hammouda, Z | 1 |
| Perinel, S | 1 |
| Balichard, S | 1 |
| Abroug, F | 1 |
| Zeni, F | 1 |
| Meziani, F | 1 |
| Bornstain, C | 1 |
| Darmon, M | 1 |
| Kelly, SJ | 1 |
| Moran, JL | 1 |
| Williams, PJ | 1 |
| Burns, K | 1 |
| Rowland, A | 1 |
| Miners, JO | 1 |
| Peake, SL | 1 |
| Nair, A | 1 |
| Lee, HY | 1 |
| Ban, GY | 1 |
| Jeong, CG | 1 |
| Park, SH | 1 |
| Kim, SH | 1 |
| Lee, YH | 1 |
| Ye, YM | 1 |
| Mrozek, S | 1 |
| Constantin, JM | 1 |
| Futier, E | 1 |
| Zenut, M | 1 |
| Ghardes, G | 1 |
| Cayot-Constantin, S | 1 |
| Bonnard, M | 1 |
| Ait-Bensaid, N | 1 |
| Eschalier, A | 1 |
| Bazin, JE | 1 |
| Chan, TY | 1 |
| Gomersall, CD | 1 |
| Cheng, CA | 1 |
| Woo, J | 1 |
| Baliga, SS | 1 |
| Jaques-Robinson, KM | 1 |
| Hadzimichalis, NM | 1 |
| Golfetti, R | 1 |
| Merrill, GF | 1 |
| Wiegand, TJ | 1 |
| Margaretten, M | 1 |
| Olson, KR | 1 |
| Danguy des Déserts, M | 1 |
| Nguyen, BV | 1 |
| Giacardi, C | 1 |
| Commandeur, D | 1 |
| Paleiron, N | 1 |
| de Maat, MM | 1 |
| Tijssen, TA | 1 |
| Brüggemann, RJ | 1 |
| Ponssen, HH | 1 |
| Allegaert, K | 1 |
| Naulaers, G | 1 |
| Krajčová, A | 1 |
| Matoušek, V | 1 |
| Duška, F | 1 |
| Giles, FJ | 1 |
| Cortes, JE | 1 |
| Halliburton, TA | 1 |
| Mallard, SJ | 1 |
| Estey, EH | 1 |
| Waddelow, TA | 1 |
| Lim, JT | 1 |
| McCormick, PA | 1 |
| Treanor, D | 1 |
| McCormack, G | 1 |
| Farrell, M | 1 |
| Billard, V | 1 |
| Servin, F | 1 |
| Guignard, B | 1 |
| Junke, E | 1 |
| Bouverne, MN | 1 |
| Hédouin, M | 1 |
| Chauvin, M | 1 |
| Domoki, F | 1 |
| Nagy, K | 1 |
| Temesvári, P | 1 |
| Bari, F | 1 |
| MacKenzie, J | 1 |
| Doan, T | 1 |
| Greenberger, PA | 1 |
| Boyle, M | 1 |
| Hundy, S | 1 |
| Torda, TA | 1 |
| Noyola, DE | 1 |
| Fernandez, M | 1 |
| Kaplan, SL | 1 |
| Bendjelid, K | 1 |
| Soubirou, JL | 1 |
| Bohe, J | 1 |
| Mackenzie, I | 1 |
| Forrest, K | 1 |
| Thompson, F | 1 |
| Marsh, R | 1 |
| Briggs, RS | 1 |
| Barrand, KG | 1 |
| Levene, M | 1 |
| Proudfoot, AT | 1 |
| Park, J | 1 |
| Leung, R | 1 |
| Plomley, R | 1 |
| Czarny, D | 1 |
| Wright, RC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Haemodynamic Effects of Paracetamol (Acetaminophen) as Extended Intravenous Infusion Versus Intravenous Bolus in Septic Shock Patients[NCT06076980] | Phase 4 | 61 participants (Actual) | Interventional | 2020-11-01 | Completed | ||
| Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.[NCT02280239] | Phase 4 | 10 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to Only enrolled 10 participants over 9 months which is less then anticipated (75).) | ||
| Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: a Randomized Controlled Trial[NCT01869699] | Phase 4 | 41 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinically significant hypotension is defined as an acute drop in mean arterial pressure requiring treatment. Treatment is defined as either a 500 cc (or greater) fluid bolus and/or an increase in inotrope support of greater than 5 mcg/min over baseline. (NCT02280239)
Timeframe: 4 hours post acetaminophen administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Control Group | 0 |
| Acetaminophen Group | 0 |
systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressures (MAP) will be monitored for 4 hours post intervention (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mmHg (Mean) | |||||
|---|---|---|---|---|---|---|
| SBP: Pre-Intervention (2 hours) | SBP: Post-Intervention (4 hours) | DBP: Pre-Intervention (2 hours) | DBP: Post-Intervention (4 hours) | MAP: Pre-Intervention (2 hours) | MAP: Post-Intervention (4 hours) | |
| Acetaminophen Group | 122.6 | 119.5 | 66.2 | 65.4 | 84.1 | 82.4 |
| Control Group | 141.6 | 141.5 | 57.4 | 51.0 | 80.8 | 75.5 |
"Total dose of all vasoactive medications will be converted to total Equidose value (with the formula 10 mcg/min norepinephrine ≈ 5 mcg/kg/min dopamine ≈ 10 mcg/min epinephrine ≈ 1 mcg/min phenylephrine ≈ 0.02 u/min vasopressin as per Russell et al. (2008)) before comparing the treatment and control groups~Only 2 of the 6 participants were on low-dose vasoactive medications, (i.e., one was on norepinephrine and the other was on milrinone) therefore the pre-planned conversion calculation was not done." (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mcg (Number) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) TOTAL Norepinephrine | Pre-Intervention (2 hours) TOTAL Milrinone | Post-Intervention (4 hours) TOTAL Norepinephrine | Post-Intervention (4 hours) TOTAL Milrinone | |
| Acetaminophen Group | NA | 6000.0 | NA | 7000.0 |
| Control Group | 167.0 | NA | 576.0 | NA |
Total crystalloid and colloid fluid will be converted the the equi-volume dose (with the ratio 1.4:1 (as per Finfer et al.(2004) & Vincent and Weil (2006) before making comparisons between the treatment and control groups. (NCT02280239)
Timeframe: 4 hours post intervention
| Intervention | mL (Mean) | |||
|---|---|---|---|---|
| Pre-Intervention (2 hours) Total fluid INTAKE | Pre-Intervention (2 hours) Total fluid OUTPUT | Post-Intervention (4 hours) Total Fluid INTAKE | Post-Intervention (4 hours) Total Fluid OUTPUT | |
| Acetaminophen Group | 298 | 370 | 612 | 852 |
| Control Group | 235 | 80 | 734 | 245 |
"Continuous measurements of core body temperature will be recorded for 6 hours. Fever burden (FB) is defined as area between the 6 hour temperature curve and 38.3°C cut-off and it is reported in °C-hour.~PRE-INTERVENTION FB: is reported for a 2 hour period. POST-INTERVENTION FB: post-intervention fever burden is reported for a 6 hour period and average hourly fever burden.~Peak Temperature: is the highest recorded temperature for the study period in °C Minimum Temperature: is the lowest recorded temperature for the study period in °C" (NCT02280239)
Timeframe: 6 hours post intervention
| Intervention | °C*hours (Mean) | |
|---|---|---|
| Pre-Intervention FB (2 hours) | Post-Intervention FB (6 hours) | |
| Acetaminophen Group | 2.16 | 5.65 |
| Control Group | 0.97 | 0.74 |
change over time core temperature after study drug administration (adjusted to baseline core temperature) (NCT01869699)
Timeframe: 2 hours
| Intervention | degrees Celsius (Mean) |
|---|---|
| Normal Saline Placebo | -0.01 |
| Acetaminophen | -0.8 |
2-hour change over time heart rate from time of study drug administration (means adjusted to baseline HR) (NCT01869699)
Timeframe: Baseline to 2 hours
| Intervention | BPM (Mean) |
|---|---|
| Normal Saline Placebo | 2 |
| Acetaminophen | -6 |
2-hour change over time SBP from study drug administration (means adjusted to baseline SBP) (NCT01869699)
Timeframe: Baseline to 2 hours
| Intervention | mm Hg (Mean) |
|---|---|
| Normal Saline Placebo | -0.1 |
| Acetaminophen | -24 |
time-weighted average core body temperature over 4 hours. Core temperature was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the core temperature values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | degrees Celsius (Mean) |
|---|---|
| Normal Saline Placebo | 38.4 |
| Acetaminophen | 37.9 |
time-weighted average heart rate over 4 hours. Heart rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the heart rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | beats per minute (Mean) |
|---|---|
| Normal Saline Placebo | 92 |
| Acetaminophen | 87 |
time weighted average for respiratory rate over 4 hours. Respiratory rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the respiratory rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | breaths per minute (Mean) |
|---|---|
| Normal Saline Placebo | 22 |
| Acetaminophen | 21 |
time-weighted average systolic blood pressure over 4 hours. Systolic blood pressure was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the systolic blood pressure values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration
| Intervention | mm Hg (Mean) |
|---|---|
| Normal Saline Placebo | 143 |
| Acetaminophen | 127 |
4 reviews available for acetaminophen and Hypotension
| Article | Year |
|---|---|
A narrative review of paracetamol-induced hypotension: Keeping the patient safe.
Topics: Acetaminophen; Critical Illness; Fever; Humans; Hypotension; Hypotension, Controlled | 2022 |
Refractory Hypotension Caused by Prazosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of the Literature.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antihy | 2018 |
Intravenous Acetaminophen-Induced Hypotension: A Review of the Current Literature.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Blood Pressure; Critical Illne | 2019 |
Haemodynamics of intravenous paracetamol in neonates.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Pressure; Female; Heart Rate; Humans; Hypotension; In | 2010 |
5 trials available for acetaminophen and Hypotension
| Article | Year |
|---|---|
The haemodynamic effects of intravenous paracetamol (acetaminophen) in healthy volunteers: a double-blind, randomized, triple crossover trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Pressure; Cross-Over Studies; Double-Blind Met | 2016 |
Haemodynamic effects of parenteral vs. enteral paracetamol in critically ill patients: a randomised controlled trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Critical Care; Critical Illness; Drug Administration | 2016 |
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote | 2010 |
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote | 2010 |
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote | 2010 |
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Care; Female; Humans; Hypote | 2010 |
Intravenous corticosteroids to reduce gemtuzumab ozogamicin infusion reactions.
Topics: Acetaminophen; Adult; Aminoglycosides; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflamm | 2003 |
Desflurane-remifentanil-nitrous oxide anaesthesia for abdominal surgery: optimal concentrations and recovery features.
Topics: Abdomen; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Inhal | 2004 |
34 other studies available for acetaminophen and Hypotension
| Article | Year |
|---|---|
Risk Factors for Intravenous Propacetamol-Induced Blood Pressure Drop in the Neurointensive Care Unit: A Retrospective Observational Study.
Topics: Acetaminophen; Blood Pressure; Fever; Humans; Hypotension; Retrospective Studies; Risk Factors | 2022 |
Duloxetine overdose causes sympathomimetic and serotonin toxicity without major complications.
Topics: Acetaminophen; Adult; Antidepressive Agents; Arrhythmias, Cardiac; Coma; Diazepam; Droperidol; Drug | 2022 |
Intravenous acetaminophen-induced non-anaphylactic shock in an older patient with COVID-19.
Topics: Acetaminophen; Administration, Intravenous; COVID-19; Humans; Hypotension | 2022 |
Hypotension Associated With IV Acetaminophen Administration in Pediatric Cardiac Patients.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Humans; Hypotension | 2019 |
The authors reply.
Topics: Acetaminophen; Child; Humans; Hypotension | 2019 |
Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly.
Topics: Acetaminophen; Animals; Benzoquinones; Blood Pressure; Hypotension; Imines; KCNQ Potassium Channels; | 2020 |
Paracetamol infusion-related severe hypotension and cardiac arrest in a child.
Topics: Acetaminophen; Antipyretics; Child, Preschool; Female; Heart Arrest; Humans; Hypotension; Infusions, | 2016 |
Hemodynamic changes in patients with influenza A after propacetamol infusion in the emergency department.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Pressure; Emergency Service, Hospital; Female; | 2018 |
Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Asphyxia Neonatorum; Chorioamnionitis; Ductus Arteriosus, P | 2018 |
Hemodynamic changes after propacetamol administration in patients with febrile UTI in the ED.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Emergency | 2018 |
Hypotensive Response to IV Acetaminophen in Pediatric Cardiac Patients.
Topics: Acetaminophen; Administration, Intravenous; Age Factors; Analgesics, Non-Narcotic; Blood Pressure; C | 2019 |
Clinically significant hemodynamic alterations after propacetamol injection in the emergency department: prevalence and risk factors.
Topics: Acetaminophen; Adult; Aged; Emergency Service, Hospital; Female; Fever; Hemodynamics; Humans; Hypote | 2017 |
Acetaminophen-Induced Changes in Systemic Blood Pressure in Critically Ill Patients: Results of a Multicenter Cohort Study.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Critical Illness; Female; Humans; Hyp | 2016 |
Does mannitol contribute to hypotension after parenteral paracetamol administration in critical care?
Topics: Acetaminophen; Critical Care; Critical Illness; Hemodynamics; Humans; Hypotension; Mannitol | 2017 |
Propacetamol poses a potential harm of adverse hypotension in male and older patients.
Topics: Acetaminophen; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over; | 2017 |
[Acetaminophene-induced hypotension in intensive care unit: a prospective study].
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Blood Pressure; Brain Injuries; Endpoint Determinatio | 2009 |
Overdose of methyldopa, indapamide and theophylline resulting in prolonged hypotension, marked diuresis and hypokalaemia in an elderly patient.
Topics: Acetaminophen; Aged, 80 and over; Analgesics, Non-Narcotic; Antihypertensive Agents; Combined Modali | 2009 |
Intravenous paracetamol and arterial hypotension. Especially in cases of infection or brain damage.
Topics: Acetaminophen; Brain Injuries; France; Humans; Hypotension; Infections; Injections, Intravenous; Pro | 2009 |
Acetaminophen reduces mitochondrial dysfunction during early cerebral postischemic reperfusion in rats.
Topics: Acetaminophen; Animals; Apoptosis; Brain; Brain Ischemia; Carotid Artery Diseases; Caspase 9; Cytoch | 2010 |
Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with IV NAC and continuous venovenous hemodiafiltration.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Antidotes; Coma; Combined Modalit | 2010 |
[Acetaminophen-induced hypotension after intravenous and oral administration].
Topics: Acetaminophen; Administration, Oral; Aged; Analgesics, Non-Narcotic; Anesthesia; Critical Care; Huma | 2010 |
Mechanism of paracetamol-induced hypotension in critically ill patients: a prospective observational cross-over study.
Topics: Acetaminophen; Aged; Antipyretics; Body Temperature; Critical Illness; Cross-Over Studies; Female; H | 2013 |
Early death from paracetamol (acetaminophen) induced fulminant hepatic failure without cerebral oedema.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Cardiovascular Diseases; Cause of Death | 2003 |
Selective inhibitors differentially affect cyclooxygenase-dependent pial arteriolar responses in newborn pigs.
Topics: Acetaminophen; Animals; Animals, Newborn; Arterioles; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge | 2005 |
Hypothermia and hypotension in Hodgkin's disease.
Topics: Acetaminophen; Female; Hodgkin Disease; Humans; Hypotension; Hypothermia; Middle Aged | 1981 |
Nearly fatal episodes of hypotension, flushing, and dyspnea in a 47-year-old woman.
Topics: Acetaminophen; Anaphylaxis; Diagnosis, Differential; Drug Hypersensitivity; Dyspnea; Female; Flushin | 1993 |
Paracetamol administration is associated with hypotension in the critically ill.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Critical Care; Critical Illness; Drug Monitoring; Fem | 1997 |
Paracetamol administration is associated with hypotension in the critically ill.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Critical Care; Critical Illness; Drug Monitoring; Fem | 1997 |
Paracetamol administration is associated with hypotension in the critically ill.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Critical Care; Critical Illness; Drug Monitoring; Fem | 1997 |
Paracetamol administration is associated with hypotension in the critically ill.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Critical Care; Critical Illness; Drug Monitoring; Fem | 1997 |
Reevaluation of antipyretics in children with enteric fever.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Blood Pressure; Child; Child, Preschool; Female | 1998 |
[Systemic arterial hypotension induced by paracetamol administration: nurse's anecdotes or facts from the intensive care unit?].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Hypotension; Intensive Care Units; Nurses | 2000 |
Effects of acetaminophen administration to patients in intensive care.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Critical Illness; Female; Heart Rate; Hum | 2000 |
Effects of acetaminophen administration to patients in intensive care.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Critical Illness; Female; Heart Rate; Hum | 2000 |
Effects of acetaminophen administration to patients in intensive care.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Critical Illness; Female; Heart Rate; Hum | 2000 |
Effects of acetaminophen administration to patients in intensive care.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Critical Illness; Female; Heart Rate; Hum | 2000 |
Ischaemic colitis and drug abuse.
Topics: Acetaminophen; Adult; Colitis; Colon; Dextropropoxyphene; Drug Combinations; Female; Humans; Hypoten | 1977 |
Changing pattern of drugs used for self-poisoning.
Topics: Acetaminophen; Antidepressive Agents, Tricyclic; Barbiturates; Benzodiazepines; Humans; Hypotension; | 1978 |
Paracetamol anaphylaxis.
Topics: Acetaminophen; Anaphylaxis; Angioedema; Aspirin; Bronchial Spasm; Cross Reactions; Humans; Hypotensi | 1992 |
A simple plan for the management of drug overdosage.
Topics: Absorption; Acetaminophen; Antidepressive Agents; Barbiturates; Body Fluids; Charcoal; Coma; Female; | 1974 |