acetaminophen has been researched along with Hepatocellular Carcinoma in 47 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective of this study was to investigate whether acetaminophen (AAP) can enhance cisplatin (CDDP) cytotoxicity against human hepatocarcinoma and hepatoblastoma cells in vitro and whether this effect can be prevented by N-acetylcysteine (NAC)." | 7.75 | Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines. ( Czauderna, P; Fuchs, J; Knap, N; Losin, M; Neuwelt, AJ; Neuwelt, EA; Pagel, MA; Warmann, S; Wozniak, M; Wu, YJ, 2009) |
| "Phenacetin pharmacokinetics and the recovery of its urinary metabolites were studied in 8 normal subjects, 16 patients with chronic hepatitis B and 12 patients with cirrhosis." | 5.12 | Impaired clearance of phenacetin in hepatic cirrhosis and fibrosis. ( He, P; Li, XD; Liu, HL; Qu, ZQ; Wu, MC; Zhang, X, 2007) |
| " This review summarises the evidence for potential therapeutic applications of non-immunosuppressive cyclophilin inhibitors, alone or in combination with other agents, in virus-induced liver diseases like hepatitis C, B or Delta, liver inflammation and fibrosis, acetaminophen-induced liver toxicity and hepatocellular carcinoma." | 4.90 | Cyclophilin inhibition as potential therapy for liver diseases. ( Naoumov, NV, 2014) |
| " The objective of this study was to investigate whether acetaminophen (AAP) can enhance cisplatin (CDDP) cytotoxicity against human hepatocarcinoma and hepatoblastoma cells in vitro and whether this effect can be prevented by N-acetylcysteine (NAC)." | 3.75 | Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines. ( Czauderna, P; Fuchs, J; Knap, N; Losin, M; Neuwelt, AJ; Neuwelt, EA; Pagel, MA; Warmann, S; Wozniak, M; Wu, YJ, 2009) |
| "The acetaminophen test was performed on 12 normal subjects and 26 HCC patients." | 2.75 | The effect of transcatheter arterial chemoembolization on phase II drug metabolism enzymes in patients with hepatocellular carcinoma. ( Jia, Y; Liu, L; Liu, X; Wang, Q; Wen, A; Zhang, Y, 2010) |
| "HepaRG is a proliferative human hepatoma-derived cell line that can be differentiated into hepatocyte-like and biliary-like cells." | 1.51 | Comparison of HepaRG cells following growth in proliferative and differentiated culture conditions reveals distinct bioenergetic profiles. ( Young, CKJ; Young, MJ, 2019) |
| "Recently, we discovered that the hepatocellular carcinoma reporter (HCR) mice previously generated in our laboratory also expressed luciferase in the spermatids of the testis." | 1.48 | A new bioluminescent imaging technology for studying oxidative stress in the testis and its impacts on fertility. ( Feng, Y; Hu, X; Li, P; Lou, H; Luo, G; Ma, Q; Ma, Z; Shao, H; Zeng, X; Zhang, L, 2018) |
| " Despite being safe at therapeutic doses, an accidental or intentional overdose can result in severe hepatotoxicity; a leading cause of drug-induced liver failure in the U." | 1.42 | Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells. ( Ercal, N; Fan, W; Khayyat, A; Tobwala, S, 2015) |
| "In the present study, using human hepatoma HepG2 cells, we have further demonstrated that macrophages are a more sensitive target for APAP-induced toxicity than HepG2 cells." | 1.42 | Differential Cytotoxicity of Acetaminophen in Mouse Macrophage J774.2 and Human Hepatoma HepG2 Cells: Protection by Diallyl Sulfide. ( John, A; Raza, H, 2015) |
| "Acetaminophen (APAP), is a safe analgesic and antipyretic drug at therapeutic dose, and is widely used in the clinic." | 1.40 | Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation. ( Chang, WJ; Chou, PL; Hung, YT; Lin, PS; Lin, SY; Liu, HC; Tseng, HH; Wei, CW; Wu, TK; Yiang, GT; Yu, YL, 2014) |
| " Toxicity studies with Diclofenac, Paracetamol and Verapamil in both cell lines show dose-response characteristics and EC(50) values similar to hHeps." | 1.38 | Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism. ( Dooley, S; Ehnert, S; Hao, L; Lin, J; Liu, L; Mühl-Benninghaus, R; Neumann, J; Nussler, AK; Nussler, N; Schyschka, L; Stöckle, U, 2012) |
| "Glycoursodeoxycholic acid failed to cause any of the effects observed for GCDCA or paracetamol." | 1.37 | Mitochondrial genome depletion dysregulates bile acid- and paracetamol-induced expression of the transporters Mdr1, Mrp1 and Mrp4 in liver cells. ( Gonzalez-Buitrago, JM; Gonzalez-Loyola, A; Gonzalez-Sanchez, E; Marin, JJ; Perez, MJ, 2011) |
| "The phenacetin test was performed in 56 normal subjects and 92 HCC patients." | 1.35 | The effect of transcatheter arterial chemoembolization on CYP1A2 activity in patients with hepatocellular carcinoma. ( Ding, N; He, P; Huang, W; Li, XD; Qu, ZQ; Wu, MC; Zhang, SL, 2008) |
| "Acetaminophen was given in the diet either alone at 2400 or 4800 p." | 1.34 | Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene. ( Duan, JD; Iatropoulos, MJ; Jeffrey, AM; Perrone, CE; Williams, GM, 2007) |
| "The new human hepatoma cell line HBG BC2 possesses the capacity of being reversibly differentiated in vitro and of maintaining a relatively higher metabolic rate when in the differentiated state (3 weeks) as compared to HepG2 cells, and thus may allow the conduct of repeated toxicity testing on cells in culture." | 1.32 | A new hepatoma cell line for toxicity testing at repeated doses. ( Arrivet, E; Bichet, N; Fabre, N; Prenez, A; Roome, NO; Trancard, J; Vericat, JA, 2003) |
| "The human hepatoma cell line, HepG2, retains many cellular functions often lost by cells in culture." | 1.29 | HepG2 cells: an in vitro model for P450-dependent metabolism of acetaminophen. ( Benson, RW; Casciano, DA; Roberts, DW; Roe, AL; Snawder, JE, 1993) |
| "(3) A human hepatoma cell line (Hep G2) was studied to obtain information on the inducibility of human UDP-GT activities by 3-methylcholanthrene-type inducers." | 1.27 | Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers. ( Bock, KW; Bock-Hennig, BS, 1987) |
| "Cells from a rat hepatoma grown in culture were found to activate methyldopa to intermediates which are bound irreversibly to cellular proteins." | 1.26 | Methyldopa binding to cells in culture. ( Dybing, E, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (8.51) | 18.7374 |
| 1990's | 3 (6.38) | 18.2507 |
| 2000's | 19 (40.43) | 29.6817 |
| 2010's | 19 (40.43) | 24.3611 |
| 2020's | 2 (4.26) | 2.80 |
| Authors | Studies |
|---|---|
| Qutob, HMH | 1 |
| Saad, RA | 1 |
| Bali, H | 1 |
| Osailan, A | 1 |
| Jaber, J | 1 |
| Alzahrani, E | 1 |
| Alyami, J | 1 |
| Elsayed, H | 1 |
| Alserihi, R | 1 |
| Shaikhomar, OA | 1 |
| Divya, KM | 1 |
| Savitha, DP | 1 |
| Krishna, GA | 1 |
| Dhanya, TM | 1 |
| Mohanan, PV | 1 |
| Shah, SF | 1 |
| Jafry, AT | 1 |
| Hussain, G | 1 |
| Kazim, AH | 1 |
| Ali, M | 1 |
| Rivani, E | 1 |
| Endraswari, PD | 1 |
| Widodo, ADW | 1 |
| Khalil, MR | 1 |
| Guldberg, R | 1 |
| Nørgård, BM | 1 |
| Uldbjerg, N | 1 |
| Wehberg, S | 1 |
| Fowobaje, KR | 1 |
| Mashood, LO | 1 |
| Ekholuenetale, M | 1 |
| Ibidoja, OJ | 1 |
| Romagnoli, A | 1 |
| D'Agostino, M | 1 |
| Pavoni, E | 1 |
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| Morel, F | 1 |
| Guguen-Guillouzo, C | 1 |
| Guillouzo, A | 1 |
| Manov, I | 3 |
| Bashenko, Y | 2 |
| Hirsh, M | 2 |
| Iancu, TC | 3 |
| Thedinga, E | 1 |
| Ullrich, A | 1 |
| Drechsler, S | 1 |
| Niendorf, R | 1 |
| Kob, A | 1 |
| Runge, D | 1 |
| Keuer, A | 1 |
| Freund, I | 1 |
| Lehmann, M | 1 |
| Ehret, R | 1 |
| Eliaz-Wolkowicz, A | 1 |
| Mizrahi, M | 1 |
| Liran, O | 1 |
| Williams, GM | 2 |
| Iatropoulos, MJ | 1 |
| Jeffrey, AM | 1 |
| Duan, JD | 1 |
| Perrone, CE | 1 |
| Roe, AL | 1 |
| Snawder, JE | 1 |
| Benson, RW | 1 |
| Roberts, DW | 1 |
| Casciano, DA | 1 |
| Nicod, L | 1 |
| Viollon, C | 1 |
| Regnier, A | 1 |
| Jacqueson, A | 1 |
| Richert, L | 1 |
| Boulares, AH | 1 |
| Giardina, C | 1 |
| Inan, MS | 1 |
| Khairallah, EA | 1 |
| Cohen, SD | 1 |
| Nozaki, I | 1 |
| Tsuji, T | 1 |
| Sakaguchi, M | 1 |
| Inoue, Y | 1 |
| Hirai, R | 1 |
| Andou, A | 1 |
| Miyazaki, M | 1 |
| Shimizu, N | 1 |
| Namba, M | 1 |
| Eleftheriou, N | 1 |
| Heathcote, J | 1 |
| Thomas, HC | 1 |
| Sherlock, S | 1 |
| Dybing, E | 1 |
| Leung, NW | 1 |
| Critchley, JA | 1 |
| Bock, KW | 1 |
| Bock-Hennig, BS | 1 |
| Yamamoto, RS | 1 |
| Richardson, HL | 1 |
| Weisburger, EK | 1 |
| Weisburger, JH | 1 |
4 reviews available for acetaminophen and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Disease Progression; Drug Therapy, Combination; Enz | 2014 |
Cyclophilin inhibition as potential therapy for liver diseases.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Cyclophil | 2014 |
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Carcinoma, Hepatocellular; Cell Death; | 2012 |
4 trials available for acetaminophen and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
The effect of transcatheter arterial chemoembolization on phase II drug metabolism enzymes in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Female; Glucuronosyltransf | 2010 |
Postoperative pain relief after hepatic resection in cirrhotic patients: the efficacy of a single small dose of ketamine plus morphine epidurally.
Topics: Acetaminophen; Adult; Aged; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Dissoc | 2003 |
Impaired clearance of phenacetin in hepatic cirrhosis and fibrosis.
Topics: Acetaminophen; Area Under Curve; Biotransformation; Carcinoma, Hepatocellular; Chemoembolization, Th | 2007 |
40 other studies available for acetaminophen and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells.
Topics: Acetaminophen; Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver | 2023 |
Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Gal | 2019 |
Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury.
Topics: Acetaminophen; Acute Lung Injury; Animals; Autophagy; Carbon Tetrachloride; Carcinoma, Hepatocellula | 2017 |
A new bioluminescent imaging technology for studying oxidative stress in the testis and its impacts on fertility.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carcinoma, Hepatocellular; Disease Models, Animal; | 2018 |
Comparison of HepaRG cells following growth in proliferative and differentiated culture conditions reveals distinct bioenergetic profiles.
Topics: Acetaminophen; Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Diff | 2019 |
Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation.
Topics: Acetaminophen; Animals; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase 9; Cell Line; Cell | 2014 |
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA D | 2014 |
Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Carcinoma, Hepatocellular; Cell | 2015 |
Differential Cytotoxicity of Acetaminophen in Mouse Macrophage J774.2 and Human Hepatoma HepG2 Cells: Protection by Diallyl Sulfide.
Topics: Acetaminophen; Adenosine Triphosphate; Allyl Compounds; Apoptosis; Carcinoma, Hepatocellular; Cell R | 2015 |
The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Animals; Benzoquinones; Carcinoma, Hepatocellul | 2008 |
The effect of transcatheter arterial chemoembolization on CYP1A2 activity in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cytochrome P-450 CY | 2008 |
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Blotting, W | 2009 |
Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection.
Topics: Acetaminophen; Adult; Aged; Arylsulfotransferase; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A2 | 2010 |
Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers, Pharmacological; Carcinoma, Hepatocell | 2010 |
Mitochondrial genome depletion dysregulates bile acid- and paracetamol-induced expression of the transporters Mdr1, Mrp1 and Mrp4 in liver cells.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfa | 2011 |
Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism.
Topics: Acetaminophen; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Cytochrome P-450 Enzyme | 2012 |
ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis.
Topics: Acetaminophen; Animals; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Disease Models, An | 2013 |
Pharmacogenetic selection of transplanted human hepatocytes in immunocompetent rats.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Carcinoma, Hepatocellular; C | 2012 |
Notch2 signaling and undifferentiated liver cancers: evidence of hepatic stem/progenitor cell origin.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylni | 2013 |
A new hepatoma cell line for toxicity testing at repeated doses.
Topics: Acetaminophen; Aspirin; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Dru | 2003 |
Mangafodipir prevents liver injury induced by acetaminophen in the mouse.
Topics: Acetaminophen; Animals; Antibodies, Monoclonal; Antioxidants; Carcinoma, Hepatocellular; Caspase 3; | 2003 |
The role of apoptosis in acetaminophen-induced injury.
Topics: Acetaminophen; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Humans; Liver; | 2003 |
Adenovirus mediated overexpression of CYP2E1 increases sensitivity of HepG2 cells to acetaminophen induced cytotoxicity.
Topics: Acetaminophen; Adenoviridae; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-45 | 2004 |
Glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells.
Topics: Acetaminophen; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Glycogen Synthase Kinase 3; H | 2005 |
Comments on "glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells".
Topics: Acetaminophen; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; fas Receptor; Glycogen Syntha | 2005 |
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells.
Topics: Acetaminophen; Aflatoxin B1; Amiodarone; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; | 2006 |
Involvement of the multidrug resistance P-glycoprotein in acetaminophen-induced toxicity in hepatoma-derived HepG2 and Hep3B cells.
Topics: Acetaminophen; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carci | 2006 |
In vitro system for the prediction of hepatotoxic effects in primary hepatocytes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animal Testing Alternatives; Animals; Carcinoma, Hepatocell | 2007 |
High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells: the role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway.
Topics: Acetaminophen; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; C | 2007 |
Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Antineoplastic Agents; Body Weight; Carcinoma, Hepato | 2007 |
HepG2 cells: an in vitro model for P450-dependent metabolism of acetaminophen.
Topics: Acetaminophen; Acetone; Biotransformation; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A1; Cytoc | 1993 |
Rifampicin and isoniazid increase acetaminophen and isoniazid cytotoxicity in human HepG2 hepatoma cells.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antitubercular Agents; Carcinoma, Hepatocellular; Cell Surv | 1997 |
Acetaminophen inhibits NF-kappaB activation by interfering with the oxidant signal in murine Hepa 1-6 cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Blotting, Western; C | 2000 |
Establishment of a human hepatoma cell line, HLE/2E1, suitable for detection of p450 2E1-related cytotoxicity.
Topics: Acetaminophen; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Division; Cell Line, Transfor | 2000 |
Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Apoptosis; Carcinoma, Hepatocellular; Cell | 2002 |
Serum alpha-fetoprotein levels in patients with acute and chronic liver disease. Relation to hepatocellular regeneration and development of primary liver cell carcinoma.
Topics: Acetaminophen; Acute Disease; Adult; alpha-Fetoproteins; Carcinoma, Hepatocellular; Chronic Disease; | 1977 |
Methyldopa binding to cells in culture.
Topics: Acetaminophen; Allopurinol; Animals; Ascorbic Acid; Carcinoma, Hepatocellular; Cells, Cultured; Defe | 1977 |
Increased oxidative metabolism of paracetamol in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Acetylcysteine; Adult; Carcinoma, Hepatocellular; Chromatography, High Pressure Liqui | 1991 |
Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers.
Topics: Acetaminophen; Adolescent; Adult; Benzopyrenes; Bilirubin; Carcinoma, Hepatocellular; Enzyme Inducti | 1987 |
Effect of p-hydroxyacetanilide on liver cancer induction by N hydroxy-N-2-fluorenylacetamide.
Topics: Acetaminophen; Administration, Oral; Animals; Carcinoma, Hepatocellular; Esters; Fluorenes; Hydroxam | 1973 |