acetaminophen has been researched along with Hepatoblastoma in 5 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Hepatoblastoma: A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective of this study was to investigate whether acetaminophen (AAP) can enhance cisplatin (CDDP) cytotoxicity against human hepatocarcinoma and hepatoblastoma cells in vitro and whether this effect can be prevented by N-acetylcysteine (NAC)." | 7.75 | Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines. ( Czauderna, P; Fuchs, J; Knap, N; Losin, M; Neuwelt, AJ; Neuwelt, EA; Pagel, MA; Warmann, S; Wozniak, M; Wu, YJ, 2009) |
| " The objective of this study was to investigate whether acetaminophen (AAP) can enhance cisplatin (CDDP) cytotoxicity against human hepatocarcinoma and hepatoblastoma cells in vitro and whether this effect can be prevented by N-acetylcysteine (NAC)." | 3.75 | Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines. ( Czauderna, P; Fuchs, J; Knap, N; Losin, M; Neuwelt, AJ; Neuwelt, EA; Pagel, MA; Warmann, S; Wozniak, M; Wu, YJ, 2009) |
| "We utilize a rabbit model of acute liver failure caused by acetaminophen administration to rabbits pretreated to enhance cytochrome p450 enzyme activity, and demonstrate that encapsulated HepG2 cells, in an extracorporeal chamber, perfused by rabbit plasma separated on-line at a rate of 2-5 mL/min, and perfused over cells at 40-60 mL/min, improve systemic parameters of liver failure (diastolic blood pressure and transjugular venous oxygen saturation)." | 1.32 | Alginate-encapsulated human hepatoblastoma cells in an extracorporeal perfusion system improve some systemic parameters of liver failure in a xenogeneic model. ( Diakanov, I; Hodgson, HJ; Khalil, M; Rahman, TM; Selden, C, 2004) |
| "Acetaminophen treatment of HepG2 cells caused oxidative damage and apoptosis." | 1.32 | N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis. ( Hirsh, M; Iancu, TC; Manov, I, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Neuwelt, AJ | 1 |
| Wu, YJ | 1 |
| Knap, N | 1 |
| Losin, M | 1 |
| Neuwelt, EA | 1 |
| Pagel, MA | 1 |
| Warmann, S | 1 |
| Fuchs, J | 1 |
| Czauderna, P | 1 |
| Wozniak, M | 1 |
| Rahman, TM | 1 |
| Selden, C | 1 |
| Khalil, M | 1 |
| Diakanov, I | 1 |
| Hodgson, HJ | 1 |
| Manov, I | 1 |
| Hirsh, M | 1 |
| Iancu, TC | 1 |
| Kobrinsky, NL | 1 |
| Sjolander, DE | 1 |
| Goldenberg, JA | 1 |
| Ortmeier, TC | 1 |
| Shear, NH | 1 |
| Malkiewicz, IM | 1 |
| Klein, D | 1 |
| Koren, G | 1 |
| Randor, S | 1 |
| Neuman, MG | 1 |
5 other studies available for acetaminophen and Hepatoblastoma
| Article | Year |
|---|---|
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Blotting, W | 2009 |
Alginate-encapsulated human hepatoblastoma cells in an extracorporeal perfusion system improve some systemic parameters of liver failure in a xenogeneic model.
Topics: Acetaminophen; Alginates; Analgesics, Non-Narcotic; Animals; Blood Pressure; Capsules; Cell Line, Tu | 2004 |
N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis.
Topics: Acetaminophen; Acetylcysteine; Antioxidants; Apoptosis; Calcium; Cations, Divalent; Cell Line, Tumor | 2004 |
Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue.
Topics: Acetaminophen; Acetylcysteine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols | 2005 |
Acetaminophen-induced toxicity to human epidermoid cell line A431 and hepatoblastoma cell line Hep G2, in vitro, is diminished by silymarin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Cell Line; Glutathione; Hepatoblastoma; Human | 1995 |