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acetaminophen and Hepatitis C

acetaminophen has been researched along with Hepatitis C in 16 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.

Research Excerpts

ExcerptRelevanceReference
"This study investigates the involvement of liver dysfunction in the modulation of paracetamol pharmacokinetic profile in genotype-4 HCV patients treated with either paracetamol alone (Para) or in combination with caffeine (Para-Caf)."9.22Bioavailability of paracetamol with/without caffeine in Egyptian patients with hepatitis C virus. ( Abdel-Aziz, AA; Ashour, AA; Atta, R; Botros, SS; El-Lakkany, NM; Hendawy, AS; Mansour, AM; Seif El-Din, SH, 2016)
"Chronic hepatitis C virus (HCV) infection predisposes patients to develop liver failure after acetaminophen (APAP) overdose."7.81Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice. ( Jaeschke, H; Lebofsky, M; Ramachandran, A; Weinman, SA; Yan, HM, 2015)
"This study investigates the involvement of liver dysfunction in the modulation of paracetamol pharmacokinetic profile in genotype-4 HCV patients treated with either paracetamol alone (Para) or in combination with caffeine (Para-Caf)."5.22Bioavailability of paracetamol with/without caffeine in Egyptian patients with hepatitis C virus. ( Abdel-Aziz, AA; Ashour, AA; Atta, R; Botros, SS; El-Lakkany, NM; Hendawy, AS; Mansour, AM; Seif El-Din, SH, 2016)
"Chronic hepatitis C virus (HCV) infection predisposes patients to develop liver failure after acetaminophen (APAP) overdose."3.81Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice. ( Jaeschke, H; Lebofsky, M; Ramachandran, A; Weinman, SA; Yan, HM, 2015)
" For example, epidemiological evidence suggests that coexistent hepatitis C virus (HCV) infection increased the risk of acetaminophen-induced acute liver injury, and was associated with an increased risk of progression to acute liver failure."3.79Acetaminophen-induced acute liver injury in HCV transgenic mice. ( Boorman, GA; Bradford, BU; Chatterjee, S; Jeannot, E; Kosyk, O; Macdonald, JM; Mason, RP; Melnyk, SB; Pogribny, IP; Rusyn, I; Tech, K; Tryndyak, VP; Uehara, T, 2013)
"Ultrastructural changes were observed in 23 consecutive patients who died from fulminant hepatic failure due to hepatitis B virus (4 cases), sporadic non-A, non-B (7), or paracetamol (acetaminophen) overdose (12) and in 3 patients with subacute hepatic necrosis of unknown cause."3.67Fulminant hepatitis. An ultrastructural study. ( Fagan, EA; McCaul, TF; Portmann, B; Tovey, G; Williams, R; Zuckerman, AJ, 1986)
"We report here the successful treatment of hepatitis C virus (HCV) transmitted from a nucleic acid testing (NAT)-negative donor to three HCV-negative recipients-two renal transplants and one liver."1.46Successful treatment of donor-derived hepatitis C viral infection in three transplant recipients from a donor at increased risk for bloodborne pathogens. ( Cameron, A; Fenkel, JM; Frank, AM; Shah, AP; Singh, P, 2017)
"Acetaminophen overdose is a frequent cause of acute liver failure."1.33Severe hepatotoxicity after therapeutic doses of acetaminophen. ( Cairon, E; Mian, P; Moling, O; PristerĂ¡, R; Rimenti, G; Rizza, F, 2006)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's3 (18.75)18.2507
2000's6 (37.50)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Edelman, EJ1
Gordon, KS1
Lo Re, V1
Skanderson, M1
Fiellin, DA1
Justice, AC1
Ramachandran, A1
Lebofsky, M1
Yan, HM1
Weinman, SA1
Jaeschke, H1
El-Lakkany, NM1
Hendawy, AS1
Seif El-Din, SH1
Ashour, AA1
Atta, R1
Abdel-Aziz, AA1
Mansour, AM1
Botros, SS1
Shah, AP1
Cameron, A1
Singh, P1
Frank, AM1
Fenkel, JM1
Nguyen, GC1
Sam, J1
Thuluvath, PJ1
Myers, RP1
Shaheen, AA1
Mehta, G1
Rothstein, KD1
Uehara, T1
Kosyk, O1
Jeannot, E1
Bradford, BU1
Tech, K1
Macdonald, JM1
Boorman, GA1
Chatterjee, S1
Mason, RP1
Melnyk, SB1
Tryndyak, VP1
Pogribny, IP1
Rusyn, I1
Wong, F1
Moling, O1
Cairon, E1
Rimenti, G1
Rizza, F1
PristerĂ¡, R1
Mian, P1
Ho, T1
Vrabec, JT1
Burton, AW1
Leen, CL1
Welsby, PD1
Leach, M1
Makris, M1
Gleeson, DC1
Preston, FE1
Williams, R3
Gimson, AE2
Harrison, PM1
Wendon, JA1
Alexander, GJ1
McCaul, TF1
Fagan, EA1
Tovey, G1
Portmann, B1
Zuckerman, AJ1

Reviews

3 reviews available for acetaminophen and Hepatitis C

ArticleYear
Health maintenance issues in cirrhosis.
    The Medical clinics of North America, 2009, Volume: 93, Issue:4

    Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Comorbidity; Disease Progression; Health

2009
Liver and kidney diseases.
    Clinics in liver disease, 2002, Volume: 6, Issue:4

    Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G

2002
Intensive liver care and management of acute hepatic failure.
    Digestive diseases and sciences, 1991, Volume: 36, Issue:6

    Topics: Acetaminophen; Critical Care; Hepatic Encephalopathy; Hepatitis B; Hepatitis C; Humans; Liver Diseas

1991

Trials

2 trials available for acetaminophen and Hepatitis C

ArticleYear
Bioavailability of paracetamol with/without caffeine in Egyptian patients with hepatitis C virus.
    European journal of clinical pharmacology, 2016, Volume: 72, Issue:5

    Topics: Acetaminophen; Adult; Aged; Analgesics; Arabs; Biological Availability; Caffeine; Female; Hepatitis

2016
Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure.
    The New England journal of medicine, 1991, Jun-27, Volume: 324, Issue:26

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Biological Transport; Chemical and Drug Induced Li

1991

Other Studies

11 other studies available for acetaminophen and Hepatitis C

ArticleYear
Acetaminophen receipt among HIV-infected patients with advanced hepatic fibrosis.
    Pharmacoepidemiology and drug safety, 2013, Volume: 22, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Cross-Sectional Studies; Drug Prescriptions; Drug Utilizati

2013
Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice.
    Archives of toxicology, 2015, Volume: 89, Issue:5

    Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Hepatitis C; Mice; Mice,

2015
Successful treatment of donor-derived hepatitis C viral infection in three transplant recipients from a donor at increased risk for bloodborne pathogens.
    Transplant infectious disease : an official journal of the Transplantation Society, 2017, Volume: 19, Issue:2

    Topics: Acetaminophen; Adult; Allografts; Antiviral Agents; Benzimidazoles; Blood-Borne Pathogens; Chemical

2017
Hepatitis C is a predictor of acute liver injury among hospitalizations for acetaminophen overdose in the United States: a nationwide analysis.
    Hepatology (Baltimore, Md.), 2008, Volume: 48, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Health Surveys; Hepatitis C;

2008
Hepatitis C, alcohol abuse, and unintentional overdoses are risk factors for acetaminophen-related hepatotoxicity.
    Hepatology (Baltimore, Md.), 2009, Volume: 49, Issue:4

    Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury;

2009
Acetaminophen-induced acute liver injury in HCV transgenic mice.
    Toxicology and applied pharmacology, 2013, Jan-15, Volume: 266, Issue:2

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Inj

2013
Severe hepatotoxicity after therapeutic doses of acetaminophen.
    Clinical therapeutics, 2006, Volume: 28, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced

2006
Hydrocodone use and sensorineural hearing loss.
    Pain physician, 2007, Volume: 10, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cochlea; Cochlear

2007
Paracetamol overdose as a cause of non-A, non-B hepatitis.
    British medical journal (Clinical research ed.), 1984, Jan-07, Volume: 288, Issue:6410

    Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; F

1984
Acute liver failure induced by alcohol and paracetamol in an HCV-infected haemophiliac.
    British journal of haematology, 1998, Volume: 103, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Alcohol Drinking; Analgesics, Non-Narcotic; Hemophilia B;

1998
Fulminant hepatitis. An ultrastructural study.
    Journal of hepatology, 1986, Volume: 2, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Autopsy; Chemical and Drug Induced Liver Injury; Female; Hepatitis

1986