Page last updated: 2024-10-22

acetaminophen and Hepatitis B

acetaminophen has been researched along with Hepatitis B in 23 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Hepatitis B: INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.

Research Excerpts

ExcerptRelevanceReference
" Since fever is an important issue with vaccine tolerability, we performed this open-label study on the efficacy and safety of prophylactic use of paracetamol (acetaminophen, Benuron®) in children administered routine 7-valent pneumococcal conjugate vaccine (PCV-7) coadministered with hexavalent vaccine (diphtheria-tetanus-acellular pertussis-hepatitis B, poliovirus, Haemophilus influenzae type b vaccine [DTPa-HBV-IPV/Hib]) in Germany."5.17An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Hae ( Baker, S; Gruber, WC; Juergens, C; Rose, MA; Schmoele-Thoma, B; Zielen, S, 2013)
" Twenty-four patients had seronegative liver failure, 15 had acetaminophen toxicity, 4 had hepatitis B virus (HBV) infection, 3 had drug-induced liver failure, 2 had autoimmune hepatitis, and 1 had mushroom poisoning."3.74Auxiliary transplantation for acute liver failure: Histopathological study of native liver regeneration. ( Dhawan, A; Hadzic, D; Heaton, N; Heneghan, MA; Knisely, AS; Mieli-Vergani, G; Muiesan, P; O'Grady, JG; Portmann, BC; Quaglia, A; Rela, M; Samyn, M; Srinivasan, P; Wendon, J, 2008)
"The most common causes of ALF were indeterminate liver failure (21%), acute hepatitis B (18%), acetaminophen ingestion (16%), and Budd-Chiari syndrome (9%)."3.74Prognostic implications of lactate, bilirubin, and etiology in German patients with acute liver failure. ( Bahr, MJ; Hadem, J; Klempnauer, J; Manns, MP; Rifai, K; Schneider, AS; Stiefel, P; Tillmann, HL; Wedemeyer, H, 2008)
"Acetaminophen overdose and idiosyncratic drug reactions have replaced viral hepatitis as the most frequent apparent causes of acute liver failure."3.71Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. ( Blei, AT; Crippin, JS; Davern, TJ; Fontana, RJ; Han, SH; Hay, JE; Hynan, L; Larson, A; Lee, WM; McCashland, TM; Ostapowicz, G; Reisch, J; Samuel, G; Schiødt, FV; Shakil, AO, 2002)
" To study this, we reviewed serum enzyme patterns early in the course of acute liver injury in patients with acute viral hepatitis A and B (n = 51), ischemic hepatitis (n = 20), and acetaminophen injury (n = 26)."3.69Serum lactic dehydrogenase in the differential diagnosis of acute hepatocellular injury. ( Cassidy, WM; Reynolds, TB, 1994)
"Low grade fever is a known adverse effect of vaccination."2.84Effect of prophylactic or therapeutic administration of paracetamol on immune response to DTwP-HepB-Hib combination vaccine in Indian infants. ( Bavdekar, SB; Chhatwal, J; D'Cor, NA; Dhaded, SM; Dhingra, MS; Dubey, AP; Dupuy, M; Gandhi, DJ; Gupta, M; Jayanth, MV; Kundu, R; Lalwani, SK; Mangarule, SA; Mathew, LG; Patnaik, BN; Ravi, MD; Ravinuthala, S; Reddy E, J; Rout, SP; Sharma, SD; Sil, A, 2017)
"Chronic hepatitis C was a frequent complication in patients treated for malignancy until the introduction of anti-HCV screening tests for blood donors."2.69Interferon treatment of chronic hepatitis C in patients cured of pediatric malignancies. ( Bortolotti, F; Brugiolo, A; Cesaro, S; Cusinato, R; Guido, M; Masiero, L; Petris, MG; Rossetti, F; Zanesco, L, 2000)
"Dengue is an acute febrile illness resulting from infection by a flavivirus transmitted by the Aedes mosquito."1.37Dengue causing fulminant hepatitis in a hepatitis B virus carrier. ( Agarwal, MP; Gharsangi, K; Giri, S; Roy, U; Sharma, V, 2011)
"Acetaminophen overdose is a frequent cause of acute liver failure."1.33Severe hepatotoxicity after therapeutic doses of acetaminophen. ( Cairon, E; Mian, P; Moling, O; Pristerá, R; Rimenti, G; Rizza, F, 2006)
"Vidarabine was studied because we use it for the treatment of patients with polyarteritis nodosa related to hepatitis B virus."1.27Pharmacokinetics of paracetamol, diclofenac and vidarabine during plasma exchange. ( Fauvelle, F; Guillevin, L; Leon, A; Niakate, MT; Petitjean, O, 1988)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19903 (13.04)18.7374
1990's3 (13.04)18.2507
2000's11 (47.83)29.6817
2010's5 (21.74)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Fontana, RJ2
Engle, RE1
Gottfried, M1
Hammed, B1
Hanje, J1
Durkalski, V1
Kleiner, DE1
Nguyen, H1
Nishimura, N1
Lee, WM2
Farci, P1
Sil, A1
Ravi, MD1
Patnaik, BN1
Dhingra, MS1
Dupuy, M1
Gandhi, DJ1
Dhaded, SM1
Dubey, AP1
Kundu, R1
Lalwani, SK1
Chhatwal, J1
Mathew, LG1
Gupta, M1
Sharma, SD1
Bavdekar, SB1
Rout, SP1
Jayanth, MV1
D'Cor, NA1
Mangarule, SA1
Ravinuthala, S1
Reddy E, J1
Rose, MA1
Juergens, C1
Schmoele-Thoma, B1
Gruber, WC1
Baker, S1
Zielen, S1
Doedée, AM1
Boland, GJ1
Pennings, JL1
de Klerk, A1
Berbers, GA1
van der Klis, FR1
de Melker, HE1
van Loveren, H1
Janssen, R1
Rodrigues, RM1
Sachinidis, A1
De Boe, V1
Rogiers, V1
Vanhaecke, T1
De Kock, J1
Quaglia, A1
Portmann, BC1
Knisely, AS2
Srinivasan, P1
Muiesan, P1
Wendon, J1
Heneghan, MA1
O'Grady, JG1
Samyn, M1
Hadzic, D1
Dhawan, A1
Mieli-Vergani, G1
Heaton, N1
Rela, M1
Mehta, G1
Rothstein, KD1
Agarwal, MP1
Giri, S1
Sharma, V1
Roy, U1
Gharsangi, K1
Ostapowicz, G1
Schiødt, FV1
Larson, A1
Davern, TJ1
Han, SH1
McCashland, TM1
Shakil, AO1
Hay, JE1
Hynan, L1
Crippin, JS1
Blei, AT1
Samuel, G1
Reisch, J1
Wong, F1
Schmidt, LE1
Wang, LP1
Hansen, BA1
Larsen, FS1
Rosmawati, M1
Moling, O1
Cairon, E1
Rimenti, G1
Rizza, F1
Pristerá, R1
Mian, P1
Hadem, J1
Stiefel, P1
Bahr, MJ1
Tillmann, HL1
Rifai, K1
Klempnauer, J1
Wedemeyer, H1
Manns, MP1
Schneider, AS1
Cassidy, WM1
Reynolds, TB1
Cesaro, S1
Bortolotti, F1
Petris, MG1
Brugiolo, A1
Cusinato, R1
Guido, M1
Rossetti, F1
Masiero, L1
Zanesco, L1
Aoki, M1
Saito, T1
Watanabe, H1
Matsuo, T1
Saito, K1
Togashi, H1
Kawata, S1
Ishikawa, K1
Aoyama, M1
Kamada, H1
Shinzawa, H1
Leung, NW1
Critchley, JA1
Williams, R2
Gimson, AE1
Fauvelle, F1
Leon, A1
Niakate, MT1
Petitjean, O1
Guillevin, L1
Wilkinson, SP1
Blendis, LM1
Parbhoo, SP1
Chalstrey, LJ1
Adjukiewicz, AB1
James, IM1
Hillenbrand, P1
Kennedy, J1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation: the NEED LESS PAIN Study"[NCT02807623]300 participants (Actual)Interventional2016-09-30Completed
A Randomized Controlled Open-Label Phase IV Multi Center Study to Assess the Effect of Antipyretic Prophylactic Treatment on the Rate of Febrile Reactions Following Concomitant Contralateral Administration of a 7-Valent Pneumococcal Conjugate Vaccine (Pre[NCT00294294]Phase 4300 participants Interventional2005-05-31Completed
A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440]3,488 participants (Actual)Observational1998-01-31Completed
Consumer Understanding and Use of Non-Prescription Analgesics, Investigation of Efficacy of Improved Acetaminophen Labeling[NCT01592448]662 participants (Actual)Observational2012-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Participants With Edema

Swelling at vaccination site (NCT02807623)
Timeframe: baseline, 48-72 hours, and 21- 28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Participants With Erythema

Reddening of the skin at vaccination site reported as the total number of participants with erythema over the duration of the study. (NCT02807623)
Timeframe: baseline, 48- 72 hours, 21-28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Lactate

A Lactate meter was used to test the exercise group for lactate readings. Two lactate tests was performed for the exercise group at Visit 1, both pre and post Influenza vaccination. The first lactate reading was taken after the blood draw.The second lactate reading was obtained from a fingerstick from the hand opposite to the vaccination arm, ideally within 3-8 minutes after the study subject completes pushups. (NCT02807623)
Timeframe: Immediately prior to Influenza vaccine and 3-8 minutes after Influenza vaccine was administered and after push-ups were completed.

Interventionmmol/L (Mean)
Lactate before pushupsLactate after pushups
Compound Exercise of Push-ups1.517.69

Level of Pain

Level of Pain will be measured by validated pain scale, using a scale of 0 ( best, no pain) to 10 (worst, as bad as imaginable, completely interferes). (NCT02807623)
Timeframe: baseline, 48-72 hours and at 21-28 days ( 3 points )

,,
Interventionunits on a scale (Mean)
Visit 1Visit 2Visit 3
Compound Exercise of Push-ups.14.19.13
Ibuprofen.39.56.28
Placebo.19.22.06

Serologic Response - A/California/7/2009

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups214.80345.09
Ibuprofen171.00239.25
Placebo216.75343.03

Serologic Response - A/Hong Kong / 4801/2014

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups149.22232.58
Ibuprofen177.78243.13
Placebo221.09296.66

Serologic Response - B/Brisbane/60/2008

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups26.0041.02
Ibuprofen17.4125.47
Placebo26.0934.09

Serologic Response - B/Phuket/3073/2013

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups32.8949.07
Ibuprofen40.1647.34
Placebo36.6944.78

Reviews

3 reviews available for acetaminophen and Hepatitis B

ArticleYear
Health maintenance issues in cirrhosis.
    The Medical clinics of North America, 2009, Volume: 93, Issue:4

    Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Comorbidity; Disease Progression; Health

2009
Liver and kidney diseases.
    Clinics in liver disease, 2002, Volume: 6, Issue:4

    Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G

2002
Intensive liver care and management of acute hepatic failure.
    Digestive diseases and sciences, 1991, Volume: 36, Issue:6

    Topics: Acetaminophen; Critical Care; Hepatic Encephalopathy; Hepatitis B; Hepatitis C; Humans; Liver Diseas

1991

Trials

5 trials available for acetaminophen and Hepatitis B

ArticleYear
Effect of prophylactic or therapeutic administration of paracetamol on immune response to DTwP-HepB-Hib combination vaccine in Indian infants.
    Vaccine, 2017, 05-19, Volume: 35, Issue:22

    Topics: Acetaminophen; Antibodies, Bacterial; Diphtheria; Diphtheria-Tetanus-Pertussis Vaccine; Female; Feve

2017
An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Hae
    BMC pediatrics, 2013, Jun-21, Volume: 13

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Bacterial Capsules; Child, Preschool; Diphtheria; Diphtheri

2013
An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Hae
    BMC pediatrics, 2013, Jun-21, Volume: 13

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Bacterial Capsules; Child, Preschool; Diphtheria; Diphtheri

2013
An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Hae
    BMC pediatrics, 2013, Jun-21, Volume: 13

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Bacterial Capsules; Child, Preschool; Diphtheria; Diphtheri

2013
An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Hae
    BMC pediatrics, 2013, Jun-21, Volume: 13

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Bacterial Capsules; Child, Preschool; Diphtheria; Diphtheri

2013
Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Female; Fever; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Va

2014
Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2003, Volume: 9, Issue:3

    Topics: Acetaminophen; Adult; Alcohol Deterrents; Analgesics, Non-Narcotic; Blood Pressure; Chemical and Dru

2003
Interferon treatment of chronic hepatitis C in patients cured of pediatric malignancies.
    Haematologica, 2000, Volume: 85, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Alopecia; Asthenia; Chlorpheniramine; DNA, V

2000

Other Studies

15 other studies available for acetaminophen and Hepatitis B

ArticleYear
Role of Hepatitis E Virus Infection in North American Patients With Severe Acute Liver Injury.
    Clinical and translational gastroenterology, 2020, Volume: 11, Issue:11

    Topics: Acetaminophen; Adult; Age Factors; Antibodies, Viral; Biopsy; Chemical and Drug Induced Liver Injury

2020
Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors.
    Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:6

    Topics: Acetaminophen; Biomarkers; Cell Differentiation; Chemical and Drug Induced Liver Injury; Child; Chil

2015
Auxiliary transplantation for acute liver failure: Histopathological study of native liver regeneration.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2008, Volume: 14, Issue:10

    Topics: Acetaminophen; Adolescent; Adult; Biopsy; Cell Proliferation; Child; Child, Preschool; Female; Hepat

2008
Dengue causing fulminant hepatitis in a hepatitis B virus carrier.
    Bioscience trends, 2011, Volume: 5, Issue:1

    Topics: Acetaminophen; Adult; Carrier State; Dengue; Enzyme-Linked Immunosorbent Assay; Hepatitis B; Humans;

2011
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
    Annals of internal medicine, 2002, Dec-17, Volume: 137, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy;

2002
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
    Annals of internal medicine, 2002, Dec-17, Volume: 137, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy;

2002
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
    Annals of internal medicine, 2002, Dec-17, Volume: 137, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy;

2002
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
    Annals of internal medicine, 2002, Dec-17, Volume: 137, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy;

2002
Summaries for patients. Acute liver failure in the United States.
    Annals of internal medicine, 2002, Dec-17, Volume: 137, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy;

2002
Aetiology and classification of acute liver failure.
    The Medical journal of Malaysia, 2005, Volume: 60 Suppl B

    Topics: Acetaminophen; Disease Progression; Hepatitis A; Hepatitis B; Humans; Liver Failure, Acute; Risk Fac

2005
Severe hepatotoxicity after therapeutic doses of acetaminophen.
    Clinical therapeutics, 2006, Volume: 28, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced

2006
Prognostic implications of lactate, bilirubin, and etiology in German patients with acute liver failure.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2008, Volume: 6, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bilirubin; Biomarkers; Budd-Chiari

2008
Serum lactic dehydrogenase in the differential diagnosis of acute hepatocellular injury.
    Journal of clinical gastroenterology, 1994, Volume: 19, Issue:2

    Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug I

1994
Clinical significance of a highly sensitive enzyme immunoassay of hepatitis B surface antigen using a novel electron spin resonance technique.
    Journal of medical virology, 2002, Volume: 66, Issue:2

    Topics: Acetaminophen; Adult; Aged; Cyclic N-Oxides; DNA, Viral; Electron Spin Resonance Spectroscopy; Femal

2002
Increased oxidative metabolism of paracetamol in patients with hepatocellular carcinoma.
    Cancer letters, 1991, Volume: 57, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Adult; Carcinoma, Hepatocellular; Chromatography, High Pressure Liqui

1991
Pharmacokinetics of paracetamol, diclofenac and vidarabine during plasma exchange.
    The International journal of artificial organs, 1988, Volume: 11, Issue:3

    Topics: Acetaminophen; Diclofenac; Hepatitis B; Humans; Plasma Exchange; Polyarteritis Nodosa; Vidarabine

1988
Frequency and type of renal and electrolyte disorders in fulminant hepatic failure.
    British medical journal, 1974, Feb-02, Volume: 1, Issue:5900

    Topics: Acetaminophen; Acute Kidney Injury; Blood Glucose; Chemical and Drug Induced Liver Injury; Creatinin

1974
Extracorporeal perfusion of pig liver in the treatment of acute liver failure.
    The British journal of surgery, 1971, Volume: 58, Issue:10

    Topics: Acetaminophen; Adult; Animals; Bilirubin; Brain; Chemical and Drug Induced Liver Injury; Electroence

1971