acetaminophen has been researched along with Hepatitis B in 23 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Hepatitis B: INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since fever is an important issue with vaccine tolerability, we performed this open-label study on the efficacy and safety of prophylactic use of paracetamol (acetaminophen, Benuron®) in children administered routine 7-valent pneumococcal conjugate vaccine (PCV-7) coadministered with hexavalent vaccine (diphtheria-tetanus-acellular pertussis-hepatitis B, poliovirus, Haemophilus influenzae type b vaccine [DTPa-HBV-IPV/Hib]) in Germany." | 5.17 | An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Hae ( Baker, S; Gruber, WC; Juergens, C; Rose, MA; Schmoele-Thoma, B; Zielen, S, 2013) |
| " Twenty-four patients had seronegative liver failure, 15 had acetaminophen toxicity, 4 had hepatitis B virus (HBV) infection, 3 had drug-induced liver failure, 2 had autoimmune hepatitis, and 1 had mushroom poisoning." | 3.74 | Auxiliary transplantation for acute liver failure: Histopathological study of native liver regeneration. ( Dhawan, A; Hadzic, D; Heaton, N; Heneghan, MA; Knisely, AS; Mieli-Vergani, G; Muiesan, P; O'Grady, JG; Portmann, BC; Quaglia, A; Rela, M; Samyn, M; Srinivasan, P; Wendon, J, 2008) |
| "The most common causes of ALF were indeterminate liver failure (21%), acute hepatitis B (18%), acetaminophen ingestion (16%), and Budd-Chiari syndrome (9%)." | 3.74 | Prognostic implications of lactate, bilirubin, and etiology in German patients with acute liver failure. ( Bahr, MJ; Hadem, J; Klempnauer, J; Manns, MP; Rifai, K; Schneider, AS; Stiefel, P; Tillmann, HL; Wedemeyer, H, 2008) |
| "Acetaminophen overdose and idiosyncratic drug reactions have replaced viral hepatitis as the most frequent apparent causes of acute liver failure." | 3.71 | Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. ( Blei, AT; Crippin, JS; Davern, TJ; Fontana, RJ; Han, SH; Hay, JE; Hynan, L; Larson, A; Lee, WM; McCashland, TM; Ostapowicz, G; Reisch, J; Samuel, G; Schiødt, FV; Shakil, AO, 2002) |
| " To study this, we reviewed serum enzyme patterns early in the course of acute liver injury in patients with acute viral hepatitis A and B (n = 51), ischemic hepatitis (n = 20), and acetaminophen injury (n = 26)." | 3.69 | Serum lactic dehydrogenase in the differential diagnosis of acute hepatocellular injury. ( Cassidy, WM; Reynolds, TB, 1994) |
| "Low grade fever is a known adverse effect of vaccination." | 2.84 | Effect of prophylactic or therapeutic administration of paracetamol on immune response to DTwP-HepB-Hib combination vaccine in Indian infants. ( Bavdekar, SB; Chhatwal, J; D'Cor, NA; Dhaded, SM; Dhingra, MS; Dubey, AP; Dupuy, M; Gandhi, DJ; Gupta, M; Jayanth, MV; Kundu, R; Lalwani, SK; Mangarule, SA; Mathew, LG; Patnaik, BN; Ravi, MD; Ravinuthala, S; Reddy E, J; Rout, SP; Sharma, SD; Sil, A, 2017) |
| "Chronic hepatitis C was a frequent complication in patients treated for malignancy until the introduction of anti-HCV screening tests for blood donors." | 2.69 | Interferon treatment of chronic hepatitis C in patients cured of pediatric malignancies. ( Bortolotti, F; Brugiolo, A; Cesaro, S; Cusinato, R; Guido, M; Masiero, L; Petris, MG; Rossetti, F; Zanesco, L, 2000) |
| "Dengue is an acute febrile illness resulting from infection by a flavivirus transmitted by the Aedes mosquito." | 1.37 | Dengue causing fulminant hepatitis in a hepatitis B virus carrier. ( Agarwal, MP; Gharsangi, K; Giri, S; Roy, U; Sharma, V, 2011) |
| "Acetaminophen overdose is a frequent cause of acute liver failure." | 1.33 | Severe hepatotoxicity after therapeutic doses of acetaminophen. ( Cairon, E; Mian, P; Moling, O; Pristerá, R; Rimenti, G; Rizza, F, 2006) |
| "Vidarabine was studied because we use it for the treatment of patients with polyarteritis nodosa related to hepatitis B virus." | 1.27 | Pharmacokinetics of paracetamol, diclofenac and vidarabine during plasma exchange. ( Fauvelle, F; Guillevin, L; Leon, A; Niakate, MT; Petitjean, O, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Fontana, RJ | 2 |
| Engle, RE | 1 |
| Gottfried, M | 1 |
| Hammed, B | 1 |
| Hanje, J | 1 |
| Durkalski, V | 1 |
| Kleiner, DE | 1 |
| Nguyen, H | 1 |
| Nishimura, N | 1 |
| Lee, WM | 2 |
| Farci, P | 1 |
| Sil, A | 1 |
| Ravi, MD | 1 |
| Patnaik, BN | 1 |
| Dhingra, MS | 1 |
| Dupuy, M | 1 |
| Gandhi, DJ | 1 |
| Dhaded, SM | 1 |
| Dubey, AP | 1 |
| Kundu, R | 1 |
| Lalwani, SK | 1 |
| Chhatwal, J | 1 |
| Mathew, LG | 1 |
| Gupta, M | 1 |
| Sharma, SD | 1 |
| Bavdekar, SB | 1 |
| Rout, SP | 1 |
| Jayanth, MV | 1 |
| D'Cor, NA | 1 |
| Mangarule, SA | 1 |
| Ravinuthala, S | 1 |
| Reddy E, J | 1 |
| Rose, MA | 1 |
| Juergens, C | 1 |
| Schmoele-Thoma, B | 1 |
| Gruber, WC | 1 |
| Baker, S | 1 |
| Zielen, S | 1 |
| Doedée, AM | 1 |
| Boland, GJ | 1 |
| Pennings, JL | 1 |
| de Klerk, A | 1 |
| Berbers, GA | 1 |
| van der Klis, FR | 1 |
| de Melker, HE | 1 |
| van Loveren, H | 1 |
| Janssen, R | 1 |
| Rodrigues, RM | 1 |
| Sachinidis, A | 1 |
| De Boe, V | 1 |
| Rogiers, V | 1 |
| Vanhaecke, T | 1 |
| De Kock, J | 1 |
| Quaglia, A | 1 |
| Portmann, BC | 1 |
| Knisely, AS | 2 |
| Srinivasan, P | 1 |
| Muiesan, P | 1 |
| Wendon, J | 1 |
| Heneghan, MA | 1 |
| O'Grady, JG | 1 |
| Samyn, M | 1 |
| Hadzic, D | 1 |
| Dhawan, A | 1 |
| Mieli-Vergani, G | 1 |
| Heaton, N | 1 |
| Rela, M | 1 |
| Mehta, G | 1 |
| Rothstein, KD | 1 |
| Agarwal, MP | 1 |
| Giri, S | 1 |
| Sharma, V | 1 |
| Roy, U | 1 |
| Gharsangi, K | 1 |
| Ostapowicz, G | 1 |
| Schiødt, FV | 1 |
| Larson, A | 1 |
| Davern, TJ | 1 |
| Han, SH | 1 |
| McCashland, TM | 1 |
| Shakil, AO | 1 |
| Hay, JE | 1 |
| Hynan, L | 1 |
| Crippin, JS | 1 |
| Blei, AT | 1 |
| Samuel, G | 1 |
| Reisch, J | 1 |
| Wong, F | 1 |
| Schmidt, LE | 1 |
| Wang, LP | 1 |
| Hansen, BA | 1 |
| Larsen, FS | 1 |
| Rosmawati, M | 1 |
| Moling, O | 1 |
| Cairon, E | 1 |
| Rimenti, G | 1 |
| Rizza, F | 1 |
| Pristerá, R | 1 |
| Mian, P | 1 |
| Hadem, J | 1 |
| Stiefel, P | 1 |
| Bahr, MJ | 1 |
| Tillmann, HL | 1 |
| Rifai, K | 1 |
| Klempnauer, J | 1 |
| Wedemeyer, H | 1 |
| Manns, MP | 1 |
| Schneider, AS | 1 |
| Cassidy, WM | 1 |
| Reynolds, TB | 1 |
| Cesaro, S | 1 |
| Bortolotti, F | 1 |
| Petris, MG | 1 |
| Brugiolo, A | 1 |
| Cusinato, R | 1 |
| Guido, M | 1 |
| Rossetti, F | 1 |
| Masiero, L | 1 |
| Zanesco, L | 1 |
| Aoki, M | 1 |
| Saito, T | 1 |
| Watanabe, H | 1 |
| Matsuo, T | 1 |
| Saito, K | 1 |
| Togashi, H | 1 |
| Kawata, S | 1 |
| Ishikawa, K | 1 |
| Aoyama, M | 1 |
| Kamada, H | 1 |
| Shinzawa, H | 1 |
| Leung, NW | 1 |
| Critchley, JA | 1 |
| Williams, R | 2 |
| Gimson, AE | 1 |
| Fauvelle, F | 1 |
| Leon, A | 1 |
| Niakate, MT | 1 |
| Petitjean, O | 1 |
| Guillevin, L | 1 |
| Wilkinson, SP | 1 |
| Blendis, LM | 1 |
| Parbhoo, SP | 1 |
| Chalstrey, LJ | 1 |
| Adjukiewicz, AB | 1 |
| James, IM | 1 |
| Hillenbrand, P | 1 |
| Kennedy, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation: the NEED LESS PAIN Study"[NCT02807623] | 300 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| A Randomized Controlled Open-Label Phase IV Multi Center Study to Assess the Effect of Antipyretic Prophylactic Treatment on the Rate of Febrile Reactions Following Concomitant Contralateral Administration of a 7-Valent Pneumococcal Conjugate Vaccine (Pre[NCT00294294] | Phase 4 | 300 participants | Interventional | 2005-05-31 | Completed | ||
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| Consumer Understanding and Use of Non-Prescription Analgesics, Investigation of Efficacy of Improved Acetaminophen Labeling[NCT01592448] | 662 participants (Actual) | Observational | 2012-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Swelling at vaccination site (NCT02807623)
Timeframe: baseline, 48-72 hours, and 21- 28 days (3 points)
| Intervention | Participants (Count of Participants) |
|---|---|
| Baseline | 0 |
| 48-72 Hours After Vaccination | 0 |
| 21-28 Days After Vaccination | 0 |
Reddening of the skin at vaccination site reported as the total number of participants with erythema over the duration of the study. (NCT02807623)
Timeframe: baseline, 48- 72 hours, 21-28 days (3 points)
| Intervention | Participants (Count of Participants) |
|---|---|
| Baseline | 0 |
| 48-72 Hours After Vaccination | 0 |
| 21-28 Days After Vaccination | 0 |
A Lactate meter was used to test the exercise group for lactate readings. Two lactate tests was performed for the exercise group at Visit 1, both pre and post Influenza vaccination. The first lactate reading was taken after the blood draw.The second lactate reading was obtained from a fingerstick from the hand opposite to the vaccination arm, ideally within 3-8 minutes after the study subject completes pushups. (NCT02807623)
Timeframe: Immediately prior to Influenza vaccine and 3-8 minutes after Influenza vaccine was administered and after push-ups were completed.
| Intervention | mmol/L (Mean) | |
|---|---|---|
| Lactate before pushups | Lactate after pushups | |
| Compound Exercise of Push-ups | 1.51 | 7.69 |
Level of Pain will be measured by validated pain scale, using a scale of 0 ( best, no pain) to 10 (worst, as bad as imaginable, completely interferes). (NCT02807623)
Timeframe: baseline, 48-72 hours and at 21-28 days ( 3 points )
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Visit 1 | Visit 2 | Visit 3 | |
| Compound Exercise of Push-ups | .14 | .19 | .13 |
| Ibuprofen | .39 | .56 | .28 |
| Placebo | .19 | .22 | .06 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 214.80 | 345.09 |
| Ibuprofen | 171.00 | 239.25 |
| Placebo | 216.75 | 343.03 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 149.22 | 232.58 |
| Ibuprofen | 177.78 | 243.13 |
| Placebo | 221.09 | 296.66 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 26.00 | 41.02 |
| Ibuprofen | 17.41 | 25.47 |
| Placebo | 26.09 | 34.09 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 32.89 | 49.07 |
| Ibuprofen | 40.16 | 47.34 |
| Placebo | 36.69 | 44.78 |
3 reviews available for acetaminophen and Hepatitis B
| Article | Year |
|---|---|
Health maintenance issues in cirrhosis.
Topics: Acetaminophen; Alcohol Drinking; Analgesics, Non-Narcotic; Comorbidity; Disease Progression; Health | 2009 |
Liver and kidney diseases.
Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G | 2002 |
Intensive liver care and management of acute hepatic failure.
Topics: Acetaminophen; Critical Care; Hepatic Encephalopathy; Hepatitis B; Hepatitis C; Humans; Liver Diseas | 1991 |
5 trials available for acetaminophen and Hepatitis B
15 other studies available for acetaminophen and Hepatitis B
| Article | Year |
|---|---|
Role of Hepatitis E Virus Infection in North American Patients With Severe Acute Liver Injury.
Topics: Acetaminophen; Adult; Age Factors; Antibodies, Viral; Biopsy; Chemical and Drug Induced Liver Injury | 2020 |
Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors.
Topics: Acetaminophen; Biomarkers; Cell Differentiation; Chemical and Drug Induced Liver Injury; Child; Chil | 2015 |
Auxiliary transplantation for acute liver failure: Histopathological study of native liver regeneration.
Topics: Acetaminophen; Adolescent; Adult; Biopsy; Cell Proliferation; Child; Child, Preschool; Female; Hepat | 2008 |
Dengue causing fulminant hepatitis in a hepatitis B virus carrier.
Topics: Acetaminophen; Adult; Carrier State; Dengue; Enzyme-Linked Immunosorbent Assay; Hepatitis B; Humans; | 2011 |
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy; | 2002 |
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy; | 2002 |
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy; | 2002 |
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy; | 2002 |
Summaries for patients. Acute liver failure in the United States.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Drug Overdose; Female; Hepatic Encephalopathy; | 2002 |
Aetiology and classification of acute liver failure.
Topics: Acetaminophen; Disease Progression; Hepatitis A; Hepatitis B; Humans; Liver Failure, Acute; Risk Fac | 2005 |
Severe hepatotoxicity after therapeutic doses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced | 2006 |
Prognostic implications of lactate, bilirubin, and etiology in German patients with acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bilirubin; Biomarkers; Budd-Chiari | 2008 |
Serum lactic dehydrogenase in the differential diagnosis of acute hepatocellular injury.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug I | 1994 |
Clinical significance of a highly sensitive enzyme immunoassay of hepatitis B surface antigen using a novel electron spin resonance technique.
Topics: Acetaminophen; Adult; Aged; Cyclic N-Oxides; DNA, Viral; Electron Spin Resonance Spectroscopy; Femal | 2002 |
Increased oxidative metabolism of paracetamol in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Acetylcysteine; Adult; Carcinoma, Hepatocellular; Chromatography, High Pressure Liqui | 1991 |
Pharmacokinetics of paracetamol, diclofenac and vidarabine during plasma exchange.
Topics: Acetaminophen; Diclofenac; Hepatitis B; Humans; Plasma Exchange; Polyarteritis Nodosa; Vidarabine | 1988 |
Frequency and type of renal and electrolyte disorders in fulminant hepatic failure.
Topics: Acetaminophen; Acute Kidney Injury; Blood Glucose; Chemical and Drug Induced Liver Injury; Creatinin | 1974 |
Extracorporeal perfusion of pig liver in the treatment of acute liver failure.
Topics: Acetaminophen; Adult; Animals; Bilirubin; Brain; Chemical and Drug Induced Liver Injury; Electroence | 1971 |