acetaminophen has been researched along with Hepatic Failure in 128 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year." | 8.82 | Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. ( Lee, WM, 2004) |
| "To summarize and compare different prognostic criteria used to determine need for liver transplantation in patients with fulminant hepatic failure secondary to acetaminophen poisoning." | 8.82 | Fulminant hepatic failure secondary to acetaminophen poisoning: a systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation. ( Amre, DK; Bailey, B; Gaudreault, P, 2003) |
| "Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well-publicized guidelines for its early detection and treatment." | 8.31 | Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. ( Alabbas, SY; Begun, J; Davies, J; Florin, TH; Giri, R; Oancea, I; Schreibner, V, 2023) |
| "Patients with acetaminophen (APAP)-induced acute liver failure (ALF) display both hyper- and hypocoagulable changes not necessarily recapitulated by standard hepatotoxic doses of APAP used in mice (eg, 300 mg/kg)." | 8.31 | Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure. ( Bouck, EG; Groeneveld, DJ; Lisman, T; Luyendyk, JP; Poole, LG; Schulte, A; Watson, VE; Wei, Z; Williams, KJ; Wolberg, AS, 2023) |
| "Acetaminophen (Act) overdose is a known inducer of liver failure in both children and adults." | 8.31 | Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study. ( Alavizadeh, SH; Doagooyan, M; Gheybi, F; Hoseinian, A; Houshangi, K; Jaafari, MR; Khoddamipour, Z; Khooei, A; Papi, A; Sahebkar, A, 2023) |
| "Acetaminophen (APAP)-induced acute liver failure (ALF) remains the most common cause of ALF in the Western world." | 8.02 | A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure. ( Agarwal, K; Aluvihare, VR; Heneghan, MA; Karvellas, CJ; Lee, WM; McPhail, MJW; Menon, K; Prachalias, A; Rose, CF; Salehi, S; Speiser, JL; Tavabie, OD, 2021) |
| "The metabolic fate, toxicity, and effects on endogenous metabolism of paracetamol (acetaminophen, APAP) in 22 female Landrace cross large white pigs were evaluated in a model of acute liver failure (ALF)." | 7.96 | Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure. ( Coen, M; Dare, TO; Dargue, R; Jalan, R; Lau, C; Lee, K; Nicholls, AW; Wilson, ID; Zia, R, 2020) |
| "Acetaminophen (APAP) overdose is one of the major etiologies of liver failure." | 7.96 | Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure. ( Chang, LY; Hsu, CY; Huang, CH; Huang, CT; Huang, SK; Lin, CY; Lin, YC; Yang, CK, 2020) |
| "Acetaminophen toxicity is common and is characterized by hepatic failure." | 7.88 | Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( Dib, C; Levine, M; Peak, DA; Pizon, AF; Stellpflug, SJ; Thomas, SH; Villano, J; Wiegand, T, 2018) |
| "In cases of severe acetaminophen-induced acute liver failure and hepatic encephalopathy, liver transplant can be the only real hope for neurologic recovery and indeed survival." | 7.80 | Liver transplant for intentional acetaminophen overdose and hepatic encephalopathy: a conflict between beneficence and justice. ( Tolchin, BD; Willey, JZ, 2014) |
| "Acetaminophen overdose is the most rapidly growing cause of fulminant hepatic failure in Western countries." | 7.79 | Accidental acetaminophen overdose results in liver transplant during second trimester of pregnancy: a case report. ( Franko, KR; Hemming, AW; Khanna, A; Mekeel, KL; Woelkers, D, 2013) |
| "Acetylcysteine is an antidote used to prevent liver failure after acetaminophen overdose." | 7.75 | Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine. ( Hayes, BD; Sarmiento, KF; Schwartz, EA, 2009) |
| "To report the occurrence of fatal acute liver failure following addition of levothyroxine to a regimen of sunitinib and acetaminophen." | 7.75 | Fatal liver failure in a patient on acetaminophen treated with sunitinib malate and levothyroxine. ( Liu, CY; Shields, AF; Weise, AM, 2009) |
| "Paracetamol (acetaminophen) poisoning is the leading cause of acute liver failure in Great Britain and the United States." | 7.74 | Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning. ( Griffiths, C; Majeed, A; Morgan, OW, 2007) |
| "Acute liver failure was induced in SCID mice by intraperitoneal injection of 400 mg/kg acetaminophen." | 7.74 | Effect of intrasplenic transplantation of immortalized human hepatocytes in the treatment of acetaminophen-induced acute liver failure SCID mice. ( Kasai, N; Kiyono, T; Matsumoto, S; Matsushita, M; Takahashi, T; Todo, S; Tsuruga, Y, 2008) |
| "A 28-year-old man with schizophrenia intentionally ingested a lethal dose of acetaminophen and an unknown quantity of ibuprofen." | 7.74 | Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose. ( Dunn, T; Katz, D; Nelson, H; Singh, G; Thomsen, D; Voigt, M; Whitaker, E, 2007) |
| "In conclusion, the Liver Dialysis Unit treatment appeared to benefit patients with acetaminophen-induced fulminant hepatic failure by reverse of the encephalopathy and spontaneous recovery of the damaged liver in selected patients." | 7.72 | Experience with liver dialysis in acetaminophen induced fulminant hepatic failure: a preliminary report. ( Ahmed, U; Akdoğan, M; El-Sahwi, K; Gürakar, A; Nour, B; Rashwan, S; Sebastian, A; Wright, H, 2003) |
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 7.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| " Although her consciousness and hemodynamic status gradually improved after treatment with N-acetylcysteine and other supportive measures, she was found to have pancytopenia, pancreatitis and hepatorenal failure during the hospitalization and eventually died 18 d post-admission." | 7.71 | Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. ( Deng, JF; Lin, TJ; Yang, CC, 2001) |
| "Drug-induced acute liver failure (ALF) is a devastating and often fatal disease mainly caused by poisoning by acetaminophen (APAP)." | 7.71 | Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse. ( Batteux, F; Calmus, Y; Ferret, PJ; Hammoud, R; Jaffray, P; Malassagne, B; Tran, A; Trébéden, H; Tulliez, M; Weill, B, 2001) |
| "The combination of acute fatty liver of pregnancy and acetaminophen toxicity resulted in acute liver failure." | 7.71 | Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report. ( Contos, MJ; Gill, EJ; Peng, TC, 2002) |
| "The model of fulminant hepatic failure induced by acetaminophen was established in dogs to observe the changes of hepatic hemodynamics and plasma histamine levels in portal vein (PV), hepatic vein (HV), abdominal aorta (AA) and inferior vena cava (ICV)." | 7.70 | An experimental study on the disorders of hepatic hemodynamics and changes of plasma histamine in dogs with fulminant hepatic failure. ( Zhang, L; Zhao, Q, 1998) |
| "Sixty-two beagle dogs were given three doses of acetaminophen over a period of 24 hr in a fulminant liver failure model that is 70% lethal in 72 hr." | 7.68 | Administration of hepatic stimulatory substance alone or with other liver growth factors does not ameliorate acetaminophen-induced liver failure. ( Azzarone, A; Carrieri, G; Cillo, U; Francavilla, A; Starzl, TE; Subbottin, V; Van Thiel, D, 1993) |
| "Liver failure is a serious hepatic dysfunction with high mortality." | 5.62 | Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats. ( Chen, L; Chen, X; Jiang, H; Li, L; Lv, L; Wang, K; Wang, Q; Yan, R, 2021) |
| " In cases of massive acetaminophen overdose, standard acetylcysteine dosing may not be adequate." | 5.37 | Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose. ( Bagdure, D; Heard, K; Monte, A; Wang, GS, 2011) |
| "Taurine treatment was effective in counteracting APAP-induced hepatic damages, oxidative stress and cellular necrosis." | 5.36 | Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. ( Das, J; Ghosh, J; Manna, P; Sil, PC, 2010) |
| "Acetaminophen-treated mice consistently displayed signs characteristic of FHF, including elevated plasma aminotransferase activity." | 5.32 | Decreased factor VIII levels during acetaminophen-induced murine fulminant hepatic failure. ( Doering, CB; Lollar, P; Nichols, CE; Parker, ET, 2003) |
| "Acetaminophen serum levels were rather low compared to cases with ingestion of one single overdose." | 5.30 | Fulminant liver failure in a young child following repeated acetaminophen overdosing. ( Babel, B; Bauer, M; Giesen, H; Patzelt, D, 1999) |
| "Acetaminophen is generally regarded as a safe antipyretic and analgetic agent and is widely used in cases of pregnancy." | 5.22 | Hepatic failure with fatal outcome during pregnancy following administration of a single therapeutic dose of acetominophen: Case report and literature review. ( Gao, Y; Huang, Y; Liang, H; Zhang, R, 2022) |
| "To summarize and compare different prognostic criteria used to determine need for liver transplantation in patients with fulminant hepatic failure secondary to acetaminophen poisoning." | 4.82 | Fulminant hepatic failure secondary to acetaminophen poisoning: a systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation. ( Amre, DK; Bailey, B; Gaudreault, P, 2003) |
| "Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year." | 4.82 | Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. ( Lee, WM, 2004) |
| "Whether accidental or intentional, acetaminophen poisoning is not uncommon; in fact, it is the most common drug-induced cause of liver failure." | 4.80 | When acetaminophen use becomes toxic. Treating acute accidental and intentional overdose. ( Kosnik, SD; Salgia, AD, 1999) |
| "Acetaminophen (Act) overdose is a known inducer of liver failure in both children and adults." | 4.31 | Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study. ( Alavizadeh, SH; Doagooyan, M; Gheybi, F; Hoseinian, A; Houshangi, K; Jaafari, MR; Khoddamipour, Z; Khooei, A; Papi, A; Sahebkar, A, 2023) |
| "Patients with acetaminophen (APAP)-induced acute liver failure (ALF) display both hyper- and hypocoagulable changes not necessarily recapitulated by standard hepatotoxic doses of APAP used in mice (eg, 300 mg/kg)." | 4.31 | Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure. ( Bouck, EG; Groeneveld, DJ; Lisman, T; Luyendyk, JP; Poole, LG; Schulte, A; Watson, VE; Wei, Z; Williams, KJ; Wolberg, AS, 2023) |
| "Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well-publicized guidelines for its early detection and treatment." | 4.31 | Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. ( Alabbas, SY; Begun, J; Davies, J; Florin, TH; Giri, R; Oancea, I; Schreibner, V, 2023) |
| "Acetaminophen (APAP)-induced acute liver failure (ALF) remains the most common cause of ALF in the Western world." | 4.02 | A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure. ( Agarwal, K; Aluvihare, VR; Heneghan, MA; Karvellas, CJ; Lee, WM; McPhail, MJW; Menon, K; Prachalias, A; Rose, CF; Salehi, S; Speiser, JL; Tavabie, OD, 2021) |
| "Acetaminophen (APAP) overdose is one of the major etiologies of liver failure." | 3.96 | Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure. ( Chang, LY; Hsu, CY; Huang, CH; Huang, CT; Huang, SK; Lin, CY; Lin, YC; Yang, CK, 2020) |
| "The metabolic fate, toxicity, and effects on endogenous metabolism of paracetamol (acetaminophen, APAP) in 22 female Landrace cross large white pigs were evaluated in a model of acute liver failure (ALF)." | 3.96 | Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure. ( Coen, M; Dare, TO; Dargue, R; Jalan, R; Lau, C; Lee, K; Nicholls, AW; Wilson, ID; Zia, R, 2020) |
| "Acetaminophen toxicity is common and is characterized by hepatic failure." | 3.88 | Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( Dib, C; Levine, M; Peak, DA; Pizon, AF; Stellpflug, SJ; Thomas, SH; Villano, J; Wiegand, T, 2018) |
| "In cases of severe acetaminophen-induced acute liver failure and hepatic encephalopathy, liver transplant can be the only real hope for neurologic recovery and indeed survival." | 3.80 | Liver transplant for intentional acetaminophen overdose and hepatic encephalopathy: a conflict between beneficence and justice. ( Tolchin, BD; Willey, JZ, 2014) |
| "Acetaminophen overdose is the most rapidly growing cause of fulminant hepatic failure in Western countries." | 3.79 | Accidental acetaminophen overdose results in liver transplant during second trimester of pregnancy: a case report. ( Franko, KR; Hemming, AW; Khanna, A; Mekeel, KL; Woelkers, D, 2013) |
| "Haemodialysis is sometimes used for patients with massive acetaminophen overdose when signs of "mitochondrial paralysis" (lactic acidosis, altered mental status, hypothermia and hyperglycaemia) are present." | 3.79 | Antidote removal during haemodialysis for massive acetaminophen overdose. ( Garland, JS; Hanly, LN; Juurlink, DN; Lenga, I; Poley, R; Sivilotti, ML; Thompson, M, 2013) |
| "The widely used over-the-counter analgesic acetaminophen (APAP) is the leading cause of acute liver failure in the United States and due to this high incidence, a recent FDA Advisory Board recommended lowering the maximum dose of APAP." | 3.77 | Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells. ( Salminen, WF; Yang, X, 2011) |
| "To report the occurrence of fatal acute liver failure following addition of levothyroxine to a regimen of sunitinib and acetaminophen." | 3.75 | Fatal liver failure in a patient on acetaminophen treated with sunitinib malate and levothyroxine. ( Liu, CY; Shields, AF; Weise, AM, 2009) |
| "Acetylcysteine is an antidote used to prevent liver failure after acetaminophen overdose." | 3.75 | Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine. ( Hayes, BD; Sarmiento, KF; Schwartz, EA, 2009) |
| "Acute liver failure was induced in SCID mice by intraperitoneal injection of 400 mg/kg acetaminophen." | 3.74 | Effect of intrasplenic transplantation of immortalized human hepatocytes in the treatment of acetaminophen-induced acute liver failure SCID mice. ( Kasai, N; Kiyono, T; Matsumoto, S; Matsushita, M; Takahashi, T; Todo, S; Tsuruga, Y, 2008) |
| "A 28-year-old man with schizophrenia intentionally ingested a lethal dose of acetaminophen and an unknown quantity of ibuprofen." | 3.74 | Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose. ( Dunn, T; Katz, D; Nelson, H; Singh, G; Thomsen, D; Voigt, M; Whitaker, E, 2007) |
| "Paracetamol (acetaminophen) poisoning is the leading cause of acute liver failure in Great Britain and the United States." | 3.74 | Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning. ( Griffiths, C; Majeed, A; Morgan, OW, 2007) |
| "The GEC was strongly associated with development of hepatic encephalopathy and death from acetaminophen-induced fulminant hepatic failure." | 3.72 | Galactose elimination capacity as a prognostic marker in patients with severe acetaminophen-induced hepatotoxicity: 10 years' experience. ( Ott, P; Schmidt, LE; Tygstrup, N, 2004) |
| "In conclusion, the Liver Dialysis Unit treatment appeared to benefit patients with acetaminophen-induced fulminant hepatic failure by reverse of the encephalopathy and spontaneous recovery of the damaged liver in selected patients." | 3.72 | Experience with liver dialysis in acetaminophen induced fulminant hepatic failure: a preliminary report. ( Ahmed, U; Akdoğan, M; El-Sahwi, K; Gürakar, A; Nour, B; Rashwan, S; Sebastian, A; Wright, H, 2003) |
| "Drug-induced acute liver failure (ALF) is a devastating and often fatal disease mainly caused by poisoning by acetaminophen (APAP)." | 3.71 | Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse. ( Batteux, F; Calmus, Y; Ferret, PJ; Hammoud, R; Jaffray, P; Malassagne, B; Tran, A; Trébéden, H; Tulliez, M; Weill, B, 2001) |
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 3.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| " Although her consciousness and hemodynamic status gradually improved after treatment with N-acetylcysteine and other supportive measures, she was found to have pancytopenia, pancreatitis and hepatorenal failure during the hospitalization and eventually died 18 d post-admission." | 3.71 | Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. ( Deng, JF; Lin, TJ; Yang, CC, 2001) |
| "The combination of acute fatty liver of pregnancy and acetaminophen toxicity resulted in acute liver failure." | 3.71 | Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report. ( Contos, MJ; Gill, EJ; Peng, TC, 2002) |
| "The model of fulminant hepatic failure induced by acetaminophen was established in dogs to observe the changes of hepatic hemodynamics and plasma histamine levels in portal vein (PV), hepatic vein (HV), abdominal aorta (AA) and inferior vena cava (ICV)." | 3.70 | An experimental study on the disorders of hepatic hemodynamics and changes of plasma histamine in dogs with fulminant hepatic failure. ( Zhang, L; Zhao, Q, 1998) |
| "Acetaminophen is widely used in human beings for analgesic purposes, but is one of the most frequent causes of poisoning in cats." | 3.69 | Comparison of N-acetylcysteine and methylene blue, alone or in combination, for treatment of acetaminophen toxicosis in cats. ( Lin, YS; Oehme, FW; Rumbeiha, WK, 1995) |
| "Sixty-two beagle dogs were given three doses of acetaminophen over a period of 24 hr in a fulminant liver failure model that is 70% lethal in 72 hr." | 3.68 | Administration of hepatic stimulatory substance alone or with other liver growth factors does not ameliorate acetaminophen-induced liver failure. ( Azzarone, A; Carrieri, G; Cillo, U; Francavilla, A; Starzl, TE; Subbottin, V; Van Thiel, D, 1993) |
| "Hepatoxicity after therapeutic dosing of acetaminophen in children is rarely reported in defined-population studies." | 2.46 | Therapeutic acetaminophen is not associated with liver injury in children: a systematic review. ( Dart, RC; Lavonas, EJ; Reynolds, KM, 2010) |
| "Supratherapeutic dosing of acetaminophen in our patients did not lead to death or liver transplant." | 1.91 | A Retrospective Review of Hospitalized Patients Receiving a Higher than Maximum Dose of Acetaminophen. ( Clark, AT; Clark, RF; Derry, K; Miller, M; Minns, AB; Stevens, C, 2023) |
| "Data from the first quarter (Q1) of 2015 to the fourth quarter (Q4) of 2021 in the US Food and Drug Administration Adverse Event Reporting System (FAERS) database were retrieved for disproportionality and Bayesian analysis." | 1.91 | Hepatic failure associated with immune checkpoint inhibitors: An analysis of the Food and Drug Administration Adverse Event Reporting System database. ( Cui, X; Guo, M; Li, D; Xu, Y; Yan, C; Zhao, Y, 2023) |
| "Sepsis and acute liver failure are associated with severe endogenous intoxication." | 1.72 | Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study. ( Hayden, MR; Shulyatnikova, T; Tumanskyi, V, 2022) |
| "Liver failure is a serious hepatic dysfunction with high mortality." | 1.62 | Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats. ( Chen, L; Chen, X; Jiang, H; Li, L; Lv, L; Wang, K; Wang, Q; Yan, R, 2021) |
| " As herbal preparations may interact with pharmaceutical drugs the following in vitro study was undertaken to determine whether the toxic effects of paracetamol on liver cell growth in culture would be exacerbated by the addition of psoralen, a furanocoumarin compound that is present in Psoralea corylifolia, a common Chinese herb." | 1.56 | Paracetamol (acetaminophen) hepatotoxicity increases in the presence of an added herbal compound. ( Britza, SM; Byard, RW; Musgrave, IF, 2020) |
| "Death commonly involved multiple substance use and abuse behaviours indicative of misuse and dependence." | 1.48 | Unintentional mortality associated with paracetamol and codeine preparations, with and without doxylamine, in Australia. ( Dobbin, M; Hopkins, RE; Pilgrim, JL, 2018) |
| "Chronic kidney disease, end-stage renal failure, and liver diseases are increasing worldwide and constitute a huge burden on health care costs, with attendant high morbidity and debility." | 1.40 | Hepato- and nephroprotective activities of a Nigerian local king tuber oyster mushroom, Pleurotus tuberregium (higher Basidiomycetes), in chemically induced organ toxicities in rats. ( Akah, PA; Ihim, SA; Laiyemo, KA; Nworu, CS; Ugwu, LE, 2014) |
| " In cases of massive acetaminophen overdose, standard acetylcysteine dosing may not be adequate." | 1.37 | Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose. ( Bagdure, D; Heard, K; Monte, A; Wang, GS, 2011) |
| "Taurine treatment was effective in counteracting APAP-induced hepatic damages, oxidative stress and cellular necrosis." | 1.36 | Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. ( Das, J; Ghosh, J; Manna, P; Sil, PC, 2010) |
| "Acetaminophen-treated mice consistently displayed signs characteristic of FHF, including elevated plasma aminotransferase activity." | 1.32 | Decreased factor VIII levels during acetaminophen-induced murine fulminant hepatic failure. ( Doering, CB; Lollar, P; Nichols, CE; Parker, ET, 2003) |
| "It is concluded that acute renal failure during paracetamol poisoning may not necessarily be followed by an evident hepatic failure." | 1.32 | [Acute renal failure after paracetamol (Acetaminophen) poisoning--report of two cases]. ( Bober, J; Ciechanowski, K; Domański, L; Kedzierska, K; Kwiatkowska, E; Myślak, M; Rózański, J, 2003) |
| "Fulminant hepatic failure is a common indication for liver transplantation." | 1.31 | Fulminant hepatic failure: outcome after listing for highly urgent liver transplantation-12 years experience in the nordic countries. ( Bjøro, K; Brandsaeter, B; Broome, U; Ericzon, BG; Foss, A; Friman, S; Höckerstedt, K; Isoniemi, H; Kirkegaard, P; Olausson, M; Schmidt, L, 2002) |
| "Fulminant hepatic failure is one of the most dramatic entities in clinical medicine, but experimental studies of its pathogenesis, evolution and treatment have, so far been limited by the lack of satisfactory animal models for testing new supportive treatment options." | 1.31 | Animal models of fulminant hepatic failure: need to test liver support devices. ( Filipponi, F; Mosca, F, 2001) |
| " immediately after paracetamol overdose (T0) and 6 h after dosing (T6) and those administered S-adenosyl-L-methionine at doses of 20 mg/kg (0." | 1.31 | Effect of different doses of S-adenosyl-L-methionine on paracetamol hepatotoxicity in a mouse model. ( Carrasco, R; Caturla, J; Esteban, A; Gutiérrez, A; Mayol, MJ; Ortiz, P; Pérez-Mateo, M, 2000) |
| "We report a case fatality from chronic acetaminophen (APAP) toxicity in an 18-month-old toddler, born 14 weeks premature, who had been receiving less than the standard toxic threshold of the pediatric suspension of APAP for 4 days prior to presentation." | 1.30 | "The silent killer": chronic acetaminophen toxicity in a toddler. ( King, W; Nichols, M; Pershad, J, 1999) |
| "Acetaminophen serum levels were rather low compared to cases with ingestion of one single overdose." | 1.30 | Fulminant liver failure in a young child following repeated acetaminophen overdosing. ( Babel, B; Bauer, M; Giesen, H; Patzelt, D, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (17.97) | 18.2507 |
| 2000's | 61 (47.66) | 29.6817 |
| 2010's | 24 (18.75) | 24.3611 |
| 2020's | 20 (15.63) | 2.80 |
| Authors | Studies |
|---|---|
| Izadi, Z | 1 |
| Gianfrancesco, MA | 1 |
| Schmajuk, G | 1 |
| Jacobsohn, L | 1 |
| Katz, P | 1 |
| Rush, S | 1 |
| Ja, C | 1 |
| Taylor, T | 1 |
| Shidara, K | 1 |
| Danila, MI | 1 |
| Wysham, KD | 1 |
| Strangfeld, A | 1 |
| Mateus, EF | 1 |
| Hyrich, KL | 1 |
| Gossec, L | 1 |
| Carmona, L | 1 |
| Lawson-Tovey, S | 1 |
| Kearsley-Fleet, L | 1 |
| Schaefer, M | 1 |
| Al-Emadi, S | 1 |
| Sparks, JA | 1 |
| Hsu, TY | 1 |
| Patel, NJ | 1 |
| Wise, L | 1 |
| Gilbert, E | 1 |
| Duarte-García, A | 1 |
| Valenzuela-Almada, MO | 1 |
| Ugarte-Gil, MF | 1 |
| Ljung, L | 1 |
| Scirè, CA | 1 |
| Carrara, G | 1 |
| Hachulla, E | 1 |
| Richez, C | 1 |
| Cacoub, P | 1 |
| Thomas, T | 1 |
| Santos, MJ | 1 |
| Bernardes, M | 1 |
| Hasseli, R | 1 |
| Regierer, A | 1 |
| Schulze-Koops, H | 1 |
| Müller-Ladner, U | 1 |
| Pons-Estel, G | 1 |
| Tanten, R | 1 |
| Nieto, RE | 1 |
| Pisoni, CN | 1 |
| Tissera, YS | 1 |
| Xavier, R | 1 |
| Lopes Marques, CD | 1 |
| Pileggi, GCS | 1 |
| Robinson, PC | 1 |
| Machado, PM | 1 |
| Sirotich, E | 1 |
| Liew, JW | 1 |
| Hausmann, JS | 1 |
| Sufka, P | 1 |
| Grainger, R | 1 |
| Bhana, S | 1 |
| Gore-Massy, M | 1 |
| Wallace, ZS | 1 |
| Yazdany, J | 1 |
| Wijers, CDM | 1 |
| Pham, L | 1 |
| Douglass, MV | 1 |
| Skaar, EP | 1 |
| Palmer, LD | 1 |
| Noto, MJ | 1 |
| Macêdo, NS | 1 |
| de Sousa Silveira, Z | 1 |
| Cordeiro, PPM | 1 |
| Coutinho, HDM | 1 |
| Júnior, JPS | 1 |
| Júnior, LJQ | 1 |
| Siyadatpanah, A | 1 |
| Kim, B | 1 |
| da Cunha, FAB | 1 |
| da Silva, MV | 1 |
| Ji, X | 1 |
| Cheng, K | 1 |
| Gao, C | 1 |
| Xie, H | 1 |
| Zhu, R | 1 |
| Luo, J | 1 |
| Baponwa, O | 1 |
| Amang, AP | 1 |
| Mezui, C | 1 |
| Koubala, BB | 1 |
| Siwe, GT | 1 |
| Vandi, VL | 1 |
| Tan, PV | 1 |
| Gao, Y | 1 |
| Zhang, R | 1 |
| Liang, H | 1 |
| Huang, Y | 1 |
| Shulyatnikova, T | 3 |
| Tumanskyi, V | 3 |
| Hayden, MR | 3 |
| Alabbas, SY | 1 |
| Giri, R | 1 |
| Oancea, I | 1 |
| Davies, J | 1 |
| Schreibner, V | 1 |
| Florin, TH | 1 |
| Begun, J | 1 |
| Xu, Y | 1 |
| Yan, C | 1 |
| Zhao, Y | 1 |
| Li, D | 1 |
| Guo, M | 1 |
| Cui, X | 1 |
| Groeneveld, DJ | 1 |
| Poole, LG | 1 |
| Bouck, EG | 1 |
| Schulte, A | 1 |
| Wei, Z | 1 |
| Williams, KJ | 1 |
| Watson, VE | 1 |
| Lisman, T | 1 |
| Wolberg, AS | 1 |
| Luyendyk, JP | 1 |
| Gheybi, F | 1 |
| Khooei, A | 1 |
| Hoseinian, A | 1 |
| Doagooyan, M | 1 |
| Houshangi, K | 1 |
| Jaafari, MR | 1 |
| Papi, A | 1 |
| Khoddamipour, Z | 1 |
| Sahebkar, A | 1 |
| Alavizadeh, SH | 1 |
| Boster, JM | 1 |
| Adams, MA | 1 |
| Moore, HB | 1 |
| Chen, Q | 1 |
| Yan, D | 1 |
| Zhang, Q | 1 |
| Zhang, G | 1 |
| Xia, M | 1 |
| Li, J | 1 |
| Zhan, W | 1 |
| Shen, E | 1 |
| Li, Z | 1 |
| Lin, L | 1 |
| Chen, YH | 1 |
| Wan, X | 1 |
| Lao, YE | 1 |
| Molden, E | 1 |
| Kringen, MK | 1 |
| Annexstad, EJ | 1 |
| Saeverud, HA | 1 |
| Jacobsen, D | 1 |
| Hovda, KE | 1 |
| Dargue, R | 1 |
| Zia, R | 1 |
| Lau, C | 1 |
| Nicholls, AW | 1 |
| Dare, TO | 1 |
| Lee, K | 1 |
| Jalan, R | 1 |
| Coen, M | 1 |
| Wilson, ID | 1 |
| James, J | 1 |
| Stauss, M | 1 |
| Ponnusamy, A | 1 |
| Myers, M | 1 |
| Britza, SM | 1 |
| Musgrave, IF | 1 |
| Byard, RW | 1 |
| Jiang, H | 1 |
| Yan, R | 1 |
| Wang, K | 1 |
| Wang, Q | 1 |
| Chen, X | 1 |
| Chen, L | 1 |
| Li, L | 1 |
| Lv, L | 1 |
| Hsu, CY | 1 |
| Lin, YC | 1 |
| Chang, LY | 1 |
| Huang, SK | 1 |
| Huang, CH | 1 |
| Yang, CK | 1 |
| Huang, CT | 1 |
| Lin, CY | 1 |
| Tavabie, OD | 1 |
| Karvellas, CJ | 1 |
| Salehi, S | 1 |
| Speiser, JL | 1 |
| Rose, CF | 1 |
| Menon, K | 1 |
| Prachalias, A | 1 |
| Heneghan, MA | 1 |
| Agarwal, K | 1 |
| Lee, WM | 3 |
| McPhail, MJW | 1 |
| Aluvihare, VR | 1 |
| Clark, AT | 1 |
| Miller, M | 1 |
| Minns, AB | 1 |
| Derry, K | 1 |
| Stevens, C | 1 |
| Clark, RF | 1 |
| Govindarajan, R | 1 |
| Ramamoorthy, G | 1 |
| Shanmugam, RM | 1 |
| Bavanandam, S | 1 |
| Murugesan, M | 1 |
| Shanmugam, C | 1 |
| Arumugam, A | 1 |
| Chellamuthu, VP | 1 |
| Venkatraj, RK | 1 |
| Sampathkumar, K | 1 |
| Rejoice, P | 1 |
| Kumar, KA | 1 |
| Adamali, S | 1 |
| Mariappan, K | 1 |
| Rathnavel, R | 1 |
| Manivasagam, VSC | 1 |
| Velusamy, A | 1 |
| Arumugam, S | 1 |
| Elikkottil, TT | 1 |
| Dev, AV | 1 |
| Sen, M | 1 |
| Palaniappan, A | 1 |
| Dorairaj, AJ | 1 |
| Kedarisetty, CK | 1 |
| Venkataraman, J | 1 |
| Karthikeyan, M | 1 |
| Somasundaram, A | 1 |
| Ramakrishnan, A | 1 |
| Madesh, VP | 1 |
| Varghese, J | 1 |
| Anupa, DK | 1 |
| Leelakrishnan, V | 1 |
| Swaminathan, M | 1 |
| Kantamaneni, R | 1 |
| Dhus, JU | 1 |
| Murugan, N | 1 |
| Natarajan, K | 1 |
| Selvi, C | 1 |
| Saithanyamurthi, HV | 1 |
| Nadaraj, A | 1 |
| Jeyaseelan, L | 1 |
| Eapen, CE | 1 |
| Wu, HY | 1 |
| Zhang, XC | 1 |
| Jia, BB | 1 |
| Cao, Y | 1 |
| Yan, K | 1 |
| Li, JY | 1 |
| Tao, L | 1 |
| Jie, ZG | 1 |
| Liu, QW | 1 |
| Hopkins, RE | 1 |
| Dobbin, M | 1 |
| Pilgrim, JL | 1 |
| Levine, M | 1 |
| Stellpflug, SJ | 1 |
| Pizon, AF | 1 |
| Peak, DA | 1 |
| Villano, J | 1 |
| Wiegand, T | 1 |
| Dib, C | 1 |
| Thomas, SH | 2 |
| Di Giorgio, A | 1 |
| Nicastro, E | 1 |
| Dalla Rosa, D | 1 |
| Nebbia, G | 1 |
| Sonzogni, A | 1 |
| D'Antiga, L | 1 |
| Franko, KR | 1 |
| Mekeel, KL | 1 |
| Woelkers, D | 1 |
| Khanna, A | 1 |
| Hemming, AW | 1 |
| Sivilotti, ML | 1 |
| Juurlink, DN | 1 |
| Garland, JS | 1 |
| Lenga, I | 1 |
| Poley, R | 1 |
| Hanly, LN | 1 |
| Thompson, M | 1 |
| Doudier, B | 1 |
| Vencatassin, H | 1 |
| Aherfi, S | 1 |
| Colson, P | 1 |
| Larsen, FS | 1 |
| Wendon, J | 3 |
| Mahmood, ND | 1 |
| Mamat, SS | 1 |
| Kamisan, FH | 1 |
| Yahya, F | 1 |
| Kamarolzaman, MF | 1 |
| Nasir, N | 1 |
| Mohtarrudin, N | 1 |
| Tohid, SF | 1 |
| Zakaria, ZA | 1 |
| Willey, JZ | 1 |
| Tolchin, BD | 1 |
| Nworu, CS | 1 |
| Ihim, SA | 1 |
| Ugwu, LE | 1 |
| Laiyemo, KA | 1 |
| Akah, PA | 1 |
| Harimoto, N | 1 |
| Wang, H | 1 |
| Ikegami, T | 1 |
| Takeishi, K | 1 |
| Itoh, S | 1 |
| Yamashita, YI | 1 |
| Yoshizumi, T | 1 |
| Aishima, S | 1 |
| Shirabe, K | 1 |
| Oda, Y | 1 |
| Maehara, Y | 1 |
| Khubutiya, MSh | 1 |
| Temnov, AA | 1 |
| Vagabov, VA | 1 |
| Sklifas, AN | 1 |
| Rogov, KA | 1 |
| Zhgutov, YA | 1 |
| Tong, HY | 1 |
| Medrano, N | 1 |
| Borobia, AM | 1 |
| Ruiz, JA | 1 |
| Martínez, AM | 1 |
| Martín, J | 1 |
| Quintana, M | 1 |
| García, S | 1 |
| Carcas, AJ | 1 |
| Ramírez, E | 1 |
| Ding, GK | 1 |
| Buckley, NA | 1 |
| Schwartz, EA | 1 |
| Hayes, BD | 1 |
| Sarmiento, KF | 1 |
| Tan, HH | 1 |
| Chang, CY | 1 |
| Martin, P | 1 |
| Weise, AM | 1 |
| Liu, CY | 1 |
| Shields, AF | 1 |
| Kittisupamongkol, W | 1 |
| Gupta, AK | 1 |
| Chan, GM | 1 |
| Greller, HA | 1 |
| Su, MK | 1 |
| Apte, U | 1 |
| Singh, S | 1 |
| Zeng, G | 1 |
| Cieply, B | 1 |
| Virji, MA | 1 |
| Wu, T | 1 |
| Monga, SP | 1 |
| Pacheco, GS | 1 |
| Panatto, JP | 2 |
| Fagundes, DA | 1 |
| Scaini, G | 2 |
| Bassani, C | 1 |
| Jeremias, IC | 2 |
| Rezin, GT | 2 |
| Constantino, L | 1 |
| Dal-Pizzol, F | 1 |
| Streck, EL | 2 |
| Das, J | 1 |
| Ghosh, J | 1 |
| Manna, P | 1 |
| Sil, PC | 1 |
| Vega, AB | 1 |
| Andreu, V | 1 |
| Perelló, A | 1 |
| Chahri, N | 1 |
| Córdova, H | 1 |
| Abad, A | 1 |
| Barenys, M | 1 |
| Lavonas, EJ | 1 |
| Reynolds, KM | 1 |
| Dart, RC | 2 |
| Ferreira, GK | 1 |
| Ramos, AC | 1 |
| Rochi, N | 1 |
| Gonçalves, CL | 1 |
| Daufenbach, JF | 1 |
| Jeremias, GC | 1 |
| Carvalho-Silva, M | 1 |
| Yang, X | 1 |
| Salminen, WF | 1 |
| Wang, GS | 1 |
| Monte, A | 1 |
| Bagdure, D | 1 |
| Heard, K | 1 |
| Wittebole, X | 1 |
| Hantson, P | 1 |
| Moniaux, N | 1 |
| Darnaud, M | 1 |
| Dos Santos, A | 1 |
| Jamot, L | 1 |
| Samuel, D | 1 |
| Amouyal, P | 1 |
| Amouyal, G | 1 |
| Bréchot, C | 1 |
| Faivre, J | 1 |
| de Meijer, VE | 1 |
| Kalish, BT | 1 |
| Meisel, JA | 1 |
| Le, HD | 1 |
| Puder, M | 1 |
| Pagano, MB | 1 |
| Hobbs, W | 1 |
| Linenberger, M | 1 |
| Delaney, M | 1 |
| Gill, EJ | 1 |
| Contos, MJ | 1 |
| Peng, TC | 1 |
| Rahman, TM | 1 |
| Selden, AC | 1 |
| Hodgson, HJ | 1 |
| Pol, S | 1 |
| Lebray, P | 1 |
| Schmidt, LE | 5 |
| Knudsen, TT | 2 |
| Dalhoff, K | 2 |
| Bendtsen, F | 2 |
| Brandsaeter, B | 2 |
| Höckerstedt, K | 2 |
| Friman, S | 2 |
| Ericzon, BG | 2 |
| Kirkegaard, P | 2 |
| Isoniemi, H | 2 |
| Olausson, M | 2 |
| Broome, U | 1 |
| Schmidt, L | 1 |
| Foss, A | 2 |
| Bjøro, K | 2 |
| Bailey, B | 1 |
| Amre, DK | 1 |
| Gaudreault, P | 1 |
| Söderdahl, G | 1 |
| Gow, PJ | 1 |
| Sood, S | 1 |
| Angus, PW | 1 |
| Doering, CB | 1 |
| Parker, ET | 1 |
| Nichols, CE | 1 |
| Lollar, P | 1 |
| McCormick, PA | 2 |
| Treanor, D | 1 |
| McCormack, G | 1 |
| Farrell, M | 1 |
| Kerr, R | 1 |
| Akdoğan, M | 1 |
| El-Sahwi, K | 1 |
| Ahmed, U | 1 |
| Rashwan, S | 1 |
| Sebastian, A | 1 |
| Wright, H | 1 |
| Nour, B | 1 |
| Gürakar, A | 1 |
| Payen, C | 1 |
| Dachraoui, A | 1 |
| Pulce, C | 1 |
| Descotes, J | 1 |
| van de Kerkhove, MP | 1 |
| Hoekstra, R | 1 |
| van Gulik, TM | 1 |
| Chamuleau, RA | 1 |
| Pruvot, FR | 1 |
| Roumilhac, D | 1 |
| Dharancy, S | 1 |
| Lambotte, P | 1 |
| Auboiron, A | 1 |
| Gambiez, L | 1 |
| Jegaden, O | 1 |
| Declerck, N | 1 |
| Ng, KL | 1 |
| Davidson, JS | 1 |
| Bathgate, AJ | 1 |
| Hyvernat, H | 1 |
| Vandenbos, F | 1 |
| Anty, R | 1 |
| Barel, R | 1 |
| Demarquay, JF | 1 |
| Saint-Paul, MC | 1 |
| Bernardin, G | 1 |
| Sumioka, I | 1 |
| Matsura, T | 1 |
| Kai, M | 1 |
| Yamada, K | 1 |
| Kedzierska, K | 1 |
| Myślak, M | 1 |
| Kwiatkowska, E | 1 |
| Bober, J | 1 |
| Rózański, J | 1 |
| Domański, L | 1 |
| Ciechanowski, K | 1 |
| Pawa, S | 1 |
| Ali, S | 1 |
| Ott, P | 1 |
| Tygstrup, N | 1 |
| Sarkar, ML | 1 |
| Fiorucci, S | 1 |
| Antonelli, E | 1 |
| Distrutti, E | 1 |
| Mencarelli, A | 1 |
| Farneti, S | 1 |
| Del Soldato, P | 1 |
| Morelli, A | 1 |
| Dalhoff, KP | 1 |
| Gandhi, H | 1 |
| Davies, N | 1 |
| Marx, M | 1 |
| Lei, XG | 1 |
| Zhu, JH | 1 |
| McClung, JP | 1 |
| Aregullin, M | 1 |
| Roneker, CA | 1 |
| Beer, C | 1 |
| Pakravan, N | 1 |
| Hudson, M | 1 |
| Smith, LT | 1 |
| Simpson, K | 1 |
| Bateman, DN | 1 |
| Nelson, H | 1 |
| Katz, D | 1 |
| Dunn, T | 1 |
| Singh, G | 1 |
| Voigt, M | 1 |
| Whitaker, E | 1 |
| Thomsen, D | 1 |
| Morgan, OW | 1 |
| Griffiths, C | 1 |
| Majeed, A | 1 |
| Ringe, B | 1 |
| Petrucci, RJ | 1 |
| Soriano, HE | 1 |
| Reynolds, JC | 1 |
| Meyers, WC | 1 |
| Tsuruga, Y | 1 |
| Kiyono, T | 1 |
| Matsushita, M | 1 |
| Takahashi, T | 1 |
| Kasai, N | 1 |
| Matsumoto, S | 1 |
| Todo, S | 1 |
| Makin, AJ | 1 |
| Williams, R | 2 |
| Oldhafer, KJ | 1 |
| Gubernatis, G | 1 |
| Schlitt, HJ | 1 |
| Rodeck, B | 1 |
| Böker, K | 1 |
| Pichlmayr, R | 1 |
| Schueler, L | 1 |
| Harper, JL | 1 |
| Devlin, J | 1 |
| Heaton, N | 1 |
| Tan, KC | 1 |
| Buckley, N | 1 |
| Whyte, I | 1 |
| Dawson, A | 1 |
| Mutimer, DJ | 1 |
| Ayres, RC | 1 |
| Neuberger, JM | 1 |
| Davies, MH | 1 |
| Holguin, J | 1 |
| Buckels, JA | 1 |
| Mayer, AD | 1 |
| McMaster, P | 1 |
| Elias, E | 1 |
| Evans, J | 1 |
| Waldron, G | 1 |
| Friedman, S | 1 |
| Gatti, M | 1 |
| Baker, T | 1 |
| Francavilla, A | 1 |
| Azzarone, A | 1 |
| Carrieri, G | 1 |
| Cillo, U | 1 |
| Van Thiel, D | 1 |
| Subbottin, V | 1 |
| Starzl, TE | 1 |
| Rumbeiha, WK | 1 |
| Lin, YS | 1 |
| Oehme, FW | 1 |
| De Roos, FJ | 1 |
| Hoffman, RS | 1 |
| Webster, PA | 1 |
| Roberts, DW | 1 |
| Benson, RW | 1 |
| Kearns, GL | 1 |
| Falk, JL | 1 |
| Washio, M | 1 |
| Inoue, N | 1 |
| Porterfield, LM | 1 |
| Young, CR | 1 |
| Mazure, CM | 1 |
| Pershad, J | 1 |
| Nichols, M | 1 |
| King, W | 1 |
| Salgia, AD | 1 |
| Kosnik, SD | 1 |
| Bauer, M | 1 |
| Babel, B | 1 |
| Giesen, H | 1 |
| Patzelt, D | 1 |
| Miles, FK | 1 |
| Kamath, R | 1 |
| Dorney, SF | 1 |
| Gaskin, KJ | 1 |
| O'Loughlin, EV | 1 |
| Newsome, PN | 1 |
| Plevris, JN | 1 |
| Nelson, LJ | 1 |
| Hayes, PC | 1 |
| Howell, TK | 1 |
| Zhang, L | 1 |
| Zhao, Q | 1 |
| Nyberg, SL | 1 |
| Pfeifer, EA | 1 |
| Casey, P | 1 |
| Barry, P | 1 |
| Laffoy, M | 1 |
| Treacy, J | 1 |
| Robinson, D | 1 |
| Smith, AM | 1 |
| Johnston, GD | 1 |
| Marino, G | 1 |
| Zimmerman, HJ | 1 |
| Lewis, JH | 1 |
| Daly, FF | 1 |
| Prescott, LF | 1 |
| Smith, IK | 1 |
| Ferret, PJ | 1 |
| Hammoud, R | 1 |
| Tulliez, M | 1 |
| Tran, A | 1 |
| Trébéden, H | 1 |
| Jaffray, P | 1 |
| Malassagne, B | 1 |
| Calmus, Y | 1 |
| Weill, B | 1 |
| Batteux, F | 1 |
| Carrasco, R | 1 |
| Pérez-Mateo, M | 1 |
| Gutiérrez, A | 1 |
| Esteban, A | 1 |
| Mayol, MJ | 1 |
| Caturla, J | 1 |
| Ortiz, P | 1 |
| Bruun, LS | 1 |
| Elkjaer, S | 1 |
| Bitsch-Larsen, D | 1 |
| Andersen, O | 1 |
| Chan, TY | 1 |
| Datta, S | 1 |
| Bhattacharyya, P | 1 |
| Ranganathan, SS | 1 |
| Fernandopulle, BM | 1 |
| de Silva, MV | 1 |
| Fernandopulle, M | 1 |
| Yang, CC | 1 |
| Deng, JF | 1 |
| Lin, TJ | 1 |
| Reddy, MS | 1 |
| Srinivas, P | 1 |
| Filipponi, F | 1 |
| Mosca, F | 1 |
| Ahola, T | 1 |
| Lapatto, R | 1 |
| Hamm, J | 1 |
| Ash, SR | 1 |
| Caldwell, CA | 1 |
| Singer, GG | 1 |
| Lowell, JA | 1 |
| Howard, TK | 1 |
| Rustgi, VK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients With Acute Liver Failure/Severe Acute Liver Injury[NCT01548690] | Phase 2 | 47 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To evaluate the effect of OCR-002 on ammonia levels in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: Baseline and 72 Hours
| Intervention | Percent Change (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 41.2 |
| Maximum Dose Level 6.65 g/24h | 16.6 |
| Maximum Dose Level 10 g/24h | 41.8 |
| Maximum Dose Level 20g/24h | 38.4 |
To evaluate the steady state pharmacokinetic and pharmacodynamic profile of OCR-002 in patients with impaired and intact renal function using urinary phenylacetylglutamine (PAGN) as a surrogate marker (NCT01548690)
Timeframe: 24 Hours after last infusion
| Intervention | micrograms per millileter (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 65.6 |
| Maximum Dose Level 6.65 g/24h | 32.2 |
| Maximum Dose Level 10 g/24h | 33.4 |
| Maximum Dose Level 20g/24h | 104.9 |
The orientation log focuses on orientation to place, time, and circumstance. There are 10 items on the orientation log, which are scored 0-3. A spontaneous correct response is awarded 3 points. A spontaneous response that is lacking or incorrect, but a correct response is provided following a logical cue is awarded 2 points. A score of 1 is given if spontaneous and cued responses are lacking or incorrect, but a correct response is provided in a recognition format. A score of 0 is given if the spontaneous, cued, or recognition format does not generate a correct answer. Scores from the 10 items are summed and the final score ranges from 0 to 30. (NCT01548690)
Timeframe: 30 Days
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 23.8 |
| Maximum Dose Level 6.65 g/24h | 24.0 |
| Maximum Dose Level 10 g/24h | 24.0 |
| Maximum Dose Level 20g/24h | 24.0 |
The West Haven Criteria (WHC) for Hepatic Encephalopathy measures the severity of encephalopathy and patient's level of consciousness. The scale ranges from 0 to 4; a minimum score of 0 represents a better outcome, and a maximum total score of 4 represents a worse outcome. A score of 0 corresponds to normal consciousness and behavior and normal neurological examination. A score of 1 corresponds to mild lack of awareness, shortened attention span, and impaired addition or subtraction; mild asterixis or tremor. A score of 2 corresponds to lethargy, disorientated or inappropriate behavior, obvious asterixis; slurred speech. A score of 3 corresponds to somnolent but arousable, gross disorientation or bizarre behavior, muscle rigidity and clonus; hyperreflexia. A score of 4 corresponds to coma and decerebrate posturing. (NCT01548690)
Timeframe: 120 hours from start of infusion
| Intervention | units on a scale (Mean) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 2.4 |
| Maximum Dose Level 6.65 g/24h | 3.2 |
| Maximum Dose Level 10 g/24h | 1.6 |
| Maximum Dose Level 20g/24h | 1.8 |
To evaluate the safety and tolerability of OCR-002 in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: 30 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Maximum Dose Level 3.33 g/24h | 0 |
| Maximum Dose Level 6.65 g/24h | 0 |
| Maximum Dose Level 10 g/24h | 0 |
| Maximum Dose Level 20g/24h | 0 |
17 reviews available for acetaminophen and Hepatic Failure
| Article | Year |
|---|---|
Hepatic failure with fatal outcome during pregnancy following administration of a single therapeutic dose of acetominophen: Case report and literature review.
Topics: Acetaminophen; Antipyretics; Drug Overdose; Fatal Outcome; Female; Humans; Liver Diseases; Liver Fai | 2022 |
Evidence and consequences of spectrum bias in studies of criteria for liver transplant in paracetamol hepatotoxicity.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Evidence-Based Medicine; Humans; Liver Failure; Live | 2008 |
[Prolonged fever and jaundice in a patient with alcoholic liver disease].
Topics: Acetaminophen; Adult; Animals; Animals, Domestic; Antibodies, Bacterial; Antipyretics; Ascites; Chem | 2010 |
Therapeutic acetaminophen is not associated with liver injury in children: a systematic review.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Child; Dose-Response Relationship, Dr | 2010 |
Use of the molecular adsorbent recirculating system (MARS™) for the management of acute poisoning with or without liver failure.
Topics: Acetaminophen; Acute Disease; Albumins; Amanita; Amphetamine; Calcium Channel Blockers; Cocaine; Hea | 2011 |
Fulminant hepatic failure secondary to acetaminophen poisoning: a systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation.
Topics: Acetaminophen; Health Status Indicators; Humans; Liver Failure; Liver Transplantation; Patient Selec | 2003 |
New insights into haemostasis in liver failure.
Topics: Acetaminophen; Acute Disease; Antithrombins; Blood Coagulation Disorders; Blood Coagulation Factors; | 2003 |
Large animal models of fulminant hepatic failure in artificial and bioartificial liver support research.
Topics: Acetaminophen; Animals; Disease Models, Animal; Dogs; Galactosamine; Guidelines as Topic; Hepatectom | 2004 |
Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Hepatitis, Viral, Human; Humans; Liver Failu | 2004 |
Acetaminophen toxicity: report of case and review of the literature.
Topics: Acetaminophen; Adult; Alcoholism; Analgesics, Non-Narcotic; Blood Coagulation; Chemical and Drug Ind | 1995 |
When acetaminophen use becomes toxic. Treating acute accidental and intentional overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Humans; Liver Failure; Poisoning | 1999 |
Animal models of fulminant hepatic failure: a critical evaluation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Dogs; Galactosamine; Human | 2000 |
Management of drug-induced liver disease.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cholestasis; Drug O | 2001 |
Fulminant hepatic failure due to acetaminophen poisoning may be less common in Hong Kong.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Drug Overdose; Female; Hong Kong; | 2001 |
[N-Acetylcysteine: new possibilities to use an old substance].
Topics: Acetaminophen; Acetylcysteine; Antioxidants; Free Radical Scavengers; Glutathione; Humans; Liver Fai | 1999 |
Acute acetaminophen overdose in adolescents and adults.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Age Factors; Antidotes; Critical Ca | 2000 |
Treatment of acetaminophen-induced hepatitis and fulminant hepatic failure with extracorporeal sorbent-based devices.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Charcoal; Hemoperfusion; Hepatitis; Humans; Liver Failure; | 2002 |
111 other studies available for acetaminophen and Hepatic Failure
| Article | Year |
|---|---|
Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Antioxidants; Bacterial Proteins; Carcinoma, Non-Smal | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study.
Topics: Acetaminophen; Animals; Delirium; Hepatic Encephalopathy; Hypertrophy; Liver Failure; Neurotoxicity | 2022 |
Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Homeodomain Proteins; Inflammation; | 2023 |
Hepatic failure associated with immune checkpoint inhibitors: An analysis of the Food and Drug Administration Adverse Event Reporting System database.
Topics: Acetaminophen; Antineoplastic Agents, Immunological; Bayes Theorem; Humans; Immune Checkpoint Inhibi | 2023 |
Liver failure cases fall after US clampdown on paracetamol.
Topics: Accidental Falls; Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; D | 2023 |
Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure.
Topics: Acetaminophen; Animals; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Fibrin; | 2023 |
Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Lipids; Liposomes; Liver; Liver Fail | 2023 |
Commentary on "Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure".
Topics: Acetaminophen; Animals; Blood Coagulation; Blood Coagulation Disorders; Liver Failure; Mice | 2023 |
Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL.
Topics: Acetaminophen; Acetylcysteine; Animals; Apoptosis; Cell Line; Chemical and Drug Induced Liver Injury | 2020 |
Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes.
Topics: Acetaminophen; Adult; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2 | 2020 |
Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chromatography, L | 2020 |
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Colitis, Ischemic; Colorimetry; Dimensional | 2020 |
Paracetamol (acetaminophen) hepatotoxicity increases in the presence of an added herbal compound.
Topics: Acetaminophen; Cell Death; Chemical and Drug Induced Liver Injury; Drug Synergism; Ficusin; Hep G2 C | 2020 |
Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; D | 2021 |
Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.
Topics: Acetaminophen; Adoptive Transfer; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liv | 2020 |
A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Biomarkers; Case-Control Studies; Chemical and Drug | 2021 |
A Retrospective Review of Hospitalized Patients Receiving a Higher than Maximum Dose of Acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Humans; Liver Failure; Patients; Retrospecti | 2023 |
Rodenticide ingestion is an important cause of acute hepatotoxicity in Tamil Nadu, southern India.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hum | 2021 |
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acetaminophen-induced acute liver failure through activating ERK and IGF-1R/PI3K/AKT signaling pathway.
Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Exosomes; Hepatocytes; H | 2021 |
Unintentional mortality associated with paracetamol and codeine preparations, with and without doxylamine, in Australia.
Topics: Accidents; Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Antiemetics; Austr | 2018 |
Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients.
Topics: Acetaminophen; Acidosis, Lactic; Adult; Blood Coagulation Disorders; Chemical and Drug Induced Liver | 2018 |
Transplant-free Survival in Chronic Liver Disease Presenting as Acute Liver Failure in Childhood.
Topics: Acetaminophen; Child; Child, Preschool; End Stage Liver Disease; Female; Graft Survival; Hepatic Enc | 2019 |
Accidental acetaminophen overdose results in liver transplant during second trimester of pregnancy: a case report.
Topics: Acetaminophen; Adult; Drug Overdose; Female; Humans; Liver Failure; Liver Transplantation; Pregnancy | 2013 |
Antidote removal during haemodialysis for massive acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; C | 2013 |
Fatal fulminant hepatitis E associated with autoimmune hepatitis and excessive paracetamol intake in Southeastern France.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Cluster Analysis; Fatal Outcome; Female; France; Hepa | 2014 |
Understanding paracetamol-induced liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Chemical and Drug Induced Liver Injury; Human | 2014 |
Amelioration of paracetamol-induced hepatotoxicity in rat by the administration of methanol extract of Muntingia calabura L. leaves.
Topics: Acetaminophen; Active Transport, Cell Nucleus; AMP-Activated Protein Kinases; Animals; Cell Nucleus; | 2014 |
Liver transplant for intentional acetaminophen overdose and hepatic encephalopathy: a conflict between beneficence and justice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Beneficence; Drug Overdose; Hepatic Encephalopathy; Humans; | 2014 |
Hepato- and nephroprotective activities of a Nigerian local king tuber oyster mushroom, Pleurotus tuberregium (higher Basidiomycetes), in chemically induced organ toxicities in rats.
Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Carbon Tetrachloride; Complex Mixtures; Disease Model | 2014 |
Education and imaging. Hepatology: Rare Stevens-Johnson syndrome and vanishing bile duct syndrome induced by acetaminophen, requiring liver transplantation.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Bile Ducts, Intrahepatic; Cholestasis; Dilat | 2015 |
Effect of Conditioned Medium and Bone Marrow Stem Cell Lysate on the Course of Acetaminophen-Induced Liver Failure.
Topics: Acetaminophen; Animals; Bone Marrow Cells; Cell Extracts; Culture Media, Conditioned; Inflammation; | 2015 |
Hepatotoxicity induced by acute and chronic paracetamol overdose in children: Where do we stand?
Topics: Acetaminophen; Acute Disease; Adolescent; Age Distribution; Analgesics, Non-Narcotic; Chemical and D | 2017 |
Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate | 2009 |
Acetaminophen hepatotoxicity: current management.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Cimetidi | 2009 |
Fatal liver failure in a patient on acetaminophen treated with sunitinib malate and levothyroxine.
Topics: Acetaminophen; Drug Therapy, Combination; Fatal Outcome; Female; Humans; Indoles; Liver Failure; Mid | 2009 |
Liver injury from diclofenac or acetaminophen?
Topics: Acetaminophen; Diclofenac; Humans; Liver; Liver Failure; Risk Assessment; Sensitivity and Specificit | 2009 |
NAC: still the way to go.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Drug-Related Side Effec | 2009 |
Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; beta Catenin; Cell Proliferation; Cytochrom | 2009 |
Brain creatine kinase activity is inhibited after hepatic failure induced by carbon tetrachloride or acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Brain; Carbon | 2009 |
Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Separation; Cytochrome P-450 CYP2E1; DNA Frag | 2010 |
The case for limiting acetaminophen-related deaths: smaller doses and unbundling the opioid-acetaminophen compounds.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; | 2010 |
Inhibition of mitochondrial respiratory chain in the brain of rats after hepatic failure induced by acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Brain; Deferoxamine; | 2011 |
Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Cell Survival; Cells, Culture | 2011 |
Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Child; Cholinergic An | 2011 |
[HIP/PAP, a new drug for acute liver failure].
Topics: Acetaminophen; Acute Disease; Animals; Antigens, Neoplasm; Biomarkers, Tumor; Chemical and Drug Indu | 2012 |
Dietary fish oil aggravates paracetamol-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2013 |
Plasma and red cell exchange transfusions for erythropoietic protoporphyria: a case report and review of the literature.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthroplasty, Replacement, Knee; Cholestasis, Intrahepatic; | 2012 |
Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Diagnos | 2002 |
A novel model of acetaminophen-induced acute hepatic failure in rabbits.
Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Anim | 2002 |
N-acetylcysteine for paracetamol poisoning: effect on prothrombin.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Diagnosis, Differe | 2002 |
Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Chemical and D | 2002 |
Fulminant hepatic failure: outcome after listing for highly urgent liver transplantation-12 years experience in the nordic countries.
Topics: ABO Blood-Group System; Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Child; Child, Pr | 2002 |
Highly urgent liver transplantation: possible impact of donor-recipient ABO matching on the outcome after transplantation.
Topics: ABO Blood-Group System; Acetaminophen; Adult; Analgesics, Non-Narcotic; Cause of Death; Child; Child | 2003 |
Serum phosphate as a predictor of outcome in acetaminophen-induced fulminant hepatic failure.
Topics: Acetaminophen; Humans; Liver Failure; Phosphates; Prognosis | 2003 |
Decreased factor VIII levels during acetaminophen-induced murine fulminant hepatic failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Factor VIII; Humans; Liver | 2003 |
Early death from paracetamol (acetaminophen) induced fulminant hepatic failure without cerebral oedema.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Cardiovascular Diseases; Cause of Death | 2003 |
The impact of current tobacco use on the outcome of paracetamol poisoning.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Liver Failure; Male; Midd | 2003 |
Experience with liver dialysis in acetaminophen induced fulminant hepatic failure: a preliminary report.
Topics: Acetaminophen; Adolescent; Adult; Female; Follow-Up Studies; Humans; Liver Failure; Liver Function T | 2003 |
Prothrombin time prolongation in paracetamol poisoning: a relevant marker of hepatic failure?
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Biomarkers; Drug Overdose; Endpoint Dete | 2003 |
Re-use of a liver graft and multi-organ procurement from a liver transplant patient.
Topics: Acetaminophen; Adult; Brain Death; Female; Heart; Humans; Liver; Liver Failure; Liver Transplantatio | 2004 |
Serum phosphate is not a reliable early predictor of outcome in paracetamol induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Liver Failure; Phosphates; Prognosis; Recovery of F | 2004 |
[Fulminant hepatitis after a therapeutic dose of acetaminophen in a chronic alcoholic patient].
Topics: Acetaminophen; Adult; Alcoholism; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; | 2004 |
Potential roles of hepatic heat shock protein 25 and 70i in protection of mice against acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chaperonin 60; Glutathione; | 2004 |
[Acute renal failure after paracetamol (Acetaminophen) poisoning--report of two cases].
Topics: Acetaminophen; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Female; Humans; Liver Failure; | 2003 |
Liver necrosis and fulminant hepatic failure in rats: protection by oxyanionic form of tungsten.
Topics: Acetaminophen; Alkaline Phosphatase; Allopurinol; Animals; Bromobenzenes; Carbon Tetrachloride Poiso | 2004 |
Galactose elimination capacity as a prognostic marker in patients with severe acetaminophen-induced hepatotoxicity: 10 years' experience.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Clinical Enzyme Tests; Female; Galactose; Humans; Li | 2004 |
Pain--the enigmatic entity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; | 2004 |
Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Caspases; Cell Separation; Cells, Cultu | 2004 |
[Effect of N-acetylcysteine on prothrombin index in patients with uncomplicated paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Chemical and Drug Induced Liver I | 2004 |
Liver transplant and obstetrics.
Topics: Acetaminophen; Adult; Congenital Abnormalities; Drug Overdose; Female; Hepatolenticular Degeneration | 2004 |
[Preventive measures against kidney damage].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Diabetic Nephropathies; Dose-Response Relati | 2005 |
Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Biotransformation; Body Weight; Cytochr | 2006 |
Liver unit admission following paracetamol overdose with concentrations below current UK treatment thresholds.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose | 2007 |
Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Chemical Analysis; Drug Overdose; Humans; Ibup | 2007 |
Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Antidepressive Agents; Aspirin; Causality; Death Certific | 2007 |
Death of a living liver donor from illicit drugs.
Topics: Acetaminophen; Adult; Child, Preschool; Drug Overdose; Ethics, Medical; Fatal Outcome; Female; Human | 2007 |
Effect of intrasplenic transplantation of immortalized human hepatocytes in the treatment of acetaminophen-induced acute liver failure SCID mice.
Topics: Acetaminophen; Acute Disease; Animals; Cell Transplantation; Graft Survival; Hepatocytes; Humans; Li | 2008 |
A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993).
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Brain Edema; Chi-S | 1995 |
Auxiliary partial orthotopic liver transplantation for acute liver failure: the Hannover experience.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Child; Female; Germany; Hepatitis A; Humans; Liver | 1994 |
Pretransplantation clinical status and outcome of emergency transplantation for acute liver failure.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Child; Emergencies; Female; Humans; Liver Failure; | 1995 |
Long term anticonvulsant therapy worsens outcome in paracetamol induced fulminant hepatic failure.
Topics: Acetaminophen; Anticonvulsants; Humans; Liver Failure | 1993 |
Serious paracetamol poisoning and the results of liver transplantation.
Topics: Acetaminophen; Acidosis; Adolescent; Adult; Aged; Female; Hepatic Encephalopathy; Humans; Liver Fail | 1994 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Adolescent; Drug Overdose; Humans; Liver Failure; Suicide, Attempted | 1993 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Drug Overdose; Humans; Liver Failure; Suicide, Attempted | 1993 |
Cesarean section after maternal acetaminophen overdose.
Topics: Acetaminophen; Adult; Anesthesia, General; Anesthesia, Obstetrical; Cesarean Section; Drug Overdose; | 1993 |
Administration of hepatic stimulatory substance alone or with other liver growth factors does not ameliorate acetaminophen-induced liver failure.
Topics: Acetaminophen; Animals; Cell Division; Dogs; Growth Substances; Intercellular Signaling Peptides and | 1993 |
Comparison of N-acetylcysteine and methylene blue, alone or in combination, for treatment of acetaminophen toxicosis in cats.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Cat Diseases; Cats; Drug Therapy, Combination; Fe | 1995 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Drug Administration Schedule; Humans; Liver Failure; Poisoning | 1996 |
Acetaminophen toxicity in children: diagnostic confirmation using a specific antigenic biomarker.
Topics: Acetaminophen; Antigens; Biomarkers; Blood Proteins; Child; Child, Preschool; Enzyme-Linked Immunoso | 1996 |
Oral N-acetylcysteine given intravenously for acetaminophen overdose: we shouldn't have to, but we must.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Free Radical Scavengers; Hum | 1998 |
The risk factors of death from the acetaminophen poisoning with antipyretic-analgesic drugs in Japan.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Disseminated In | 1997 |
Right upper quadrant tenderness in a drinker.
Topics: Abdominal Pain; Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Humans; Liver Failure; Male; Mi | 1998 |
Fulminant hepatic failure from acetaminophen in an anorexic patient treated with carbamazepine.
Topics: Acetaminophen; Adolescent; Anorexia Nervosa; Carbamazepine; Drug Overdose; Drug Synergism; Drug Ther | 1998 |
"The silent killer": chronic acetaminophen toxicity in a toddler.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chronic Disease; Fatal Outcome; Humans; Infant; Infant, New | 1999 |
Fulminant liver failure in a young child following repeated acetaminophen overdosing.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cause of Death; Child, Preschool; Drug Overdose; Female; Hu | 1999 |
Accidental paracetamol overdosing and fulminant hepatic failure in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Drug Overdose; Humans; Infant; Liv | 1999 |
Paracetamol-induced fulminant hepatic failure in a child after 5 days of therapeutic doses.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Humans; Liver Failure; Time Factor | 2000 |
An experimental study on the disorders of hepatic hemodynamics and changes of plasma histamine in dogs with fulminant hepatic failure.
Topics: Acetaminophen; Animals; Dogs; Female; Hemodynamics; Histamine; Liver Circulation; Liver Failure; Mal | 1998 |
Cerebral edema with herniation during acetaminophen-induced fulminant hepatic failure.
Topics: Acetaminophen; Adult; Anticonvulsants; Brain; Brain Edema; Drug Synergism; Encephalocele; Fatal Outc | 2000 |
Delays in administration of acetylcysteine in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Drug Overdose; Humans; Ireland; Liver Failur | 2000 |
Severity of overdose after restriction of paracetamol availability: retrospective study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chi-Square Distribution; Drug Overdose; Humans; Liver Failu | 2000 |
Accidental paracetamol overdosing and fulminant hepatic failure in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Overdose; Humans; Liver Failure | 2000 |
The Tylenol scare.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Liver Failure; United States | 2001 |
Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse.
Topics: Acetaminophen; Acute Disease; Animals; Caspases; Cytochrome c Group; Enzyme Activation; Female; Free | 2001 |
Effect of different doses of S-adenosyl-L-methionine on paracetamol hepatotoxicity in a mouse model.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Female; Free Radical Scavengers; L | 2000 |
Hepatic failure in a child after acetaminophen and sevoflurane exposure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Child, Preschool; Female; Humans; | 2001 |
Effect of a herbal protein CI-1, purified from Cajanus indicus on the ultrastructural study of hepatocytes, in models of liver failure in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Central Nervous System Depre | 2001 |
Fulminant heptic failure in a child following paracetamol overdosing.
Topics: Acetaminophen; Child; Drug Overdose; Fatal Outcome; Humans; Liver Failure; Male | 2001 |
Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Coma; Diagnosis, Diff | 2001 |
Hepatic failure after rectal acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Humans; Liver Failure; Suppositories | 2002 |
Animal models of fulminant hepatic failure: need to test liver support devices.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Dogs; Galactosamine; Hepat | 2001 |