acetaminophen has been researched along with Hemolysis in 30 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen inhibits cell-free hemoglobin-induced lipid peroxidation and improves renal function in severe falciparum malaria but has not been evaluated in other infections with prominent hemolysis, including Plasmodium knowlesi malaria." | 9.51 | The Effect of Regularly Dosed Acetaminophen vs No Acetaminophen on Renal Function in Plasmodium knowlesi Malaria (PACKNOW): A Randomized, Controlled Trial. ( Anstey, NM; Barber, BE; Birrell, GW; Cooper, DJ; Dondorp, AM; Edstein, MD; Grigg, MJ; Koleth, G; Menon, J; Patel, A; Piera, KA; Plewes, K; Rajahram, GS; Tarning, J; Wattanakul, T; Wen Yeo, T; William, T, 2022) |
| "Patients with glucose-6-phosphate dehydrogenase deficiency who overdose with acetaminophen should be monitored for the possible development of subsequent drug-induced hemolysis." | 8.79 | Hemolysis after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency. ( Perry, HE; Shannon, MW; Woolf, AD; Wright, RO, 1996) |
| "We evaluated the effect of hemolysis, icterus and lipemia on 3 acetaminophen assays: namely the Syva® EMIT®, the Microgenics DRI® assay, and the Roche assay on a Roche Cobas® c501 or an Integra 800 analyzer." | 7.88 | Effect of hemolysis, icterus, and lipemia on three acetaminophen assays: Potential medical consequences of false positive results. ( Fan, SL; Kellogg, MD; Zhang, YV, 2018) |
| "Intravenous acetylcysteine (Acetadote™ in the US) is the treatment of choice for acute acetaminophen poisoning in most of the world." | 7.77 | Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose. ( Mullins, ME; Vitkovitsky, IV, 2011) |
| "We compared the COBAS(R) acetaminophen and salicylate assays (Roche Diagnostics) with the Stanbio GDS assays (Stanbio Laboratories) that are currently used in our laboratory with respect to interferences from hemolysis and lipemia." | 7.74 | Effects of hemolysis and lipemia on the COBAS salicylate and acetaminophen assays compared to GDS assays. ( Clarke, W; Meany, D; Schowinsky, J, 2008) |
| "Acetaminophen inhibits cell-free hemoglobin-induced lipid peroxidation and improves renal function in severe falciparum malaria but has not been evaluated in other infections with prominent hemolysis, including Plasmodium knowlesi malaria." | 5.51 | The Effect of Regularly Dosed Acetaminophen vs No Acetaminophen on Renal Function in Plasmodium knowlesi Malaria (PACKNOW): A Randomized, Controlled Trial. ( Anstey, NM; Barber, BE; Birrell, GW; Cooper, DJ; Dondorp, AM; Edstein, MD; Grigg, MJ; Koleth, G; Menon, J; Patel, A; Piera, KA; Plewes, K; Rajahram, GS; Tarning, J; Wattanakul, T; Wen Yeo, T; William, T, 2022) |
| "Fever and concomitant infection, through an increment of erythrocyte glutathione depletion, sensitized the infant to the haemolytic event." | 5.37 | Acute haemolytic crisis due to concomitant presence of infection and possible altered acetaminophen catabolism in a Philipino child carrying the G6PD-Vanua Lava mutation. ( Capoluongo, E; Concolino, P; De Luca, D; Giardina, B; Maurizi, P; Minucci, A; Torti, E; Zuppi, C, 2011) |
| "Acetaminophen was the most likely cause of the hemolysis." | 5.31 | Hemolysis as a potential complication of acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency. ( Sklar, GE, 2002) |
| "Patients with glucose-6-phosphate dehydrogenase deficiency who overdose with acetaminophen should be monitored for the possible development of subsequent drug-induced hemolysis." | 4.79 | Hemolysis after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency. ( Perry, HE; Shannon, MW; Woolf, AD; Wright, RO, 1996) |
| "We evaluated the effect of hemolysis, icterus and lipemia on 3 acetaminophen assays: namely the Syva® EMIT®, the Microgenics DRI® assay, and the Roche assay on a Roche Cobas® c501 or an Integra 800 analyzer." | 3.88 | Effect of hemolysis, icterus, and lipemia on three acetaminophen assays: Potential medical consequences of false positive results. ( Fan, SL; Kellogg, MD; Zhang, YV, 2018) |
| "Intravenous acetylcysteine (Acetadote™ in the US) is the treatment of choice for acute acetaminophen poisoning in most of the world." | 3.77 | Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose. ( Mullins, ME; Vitkovitsky, IV, 2011) |
| "We compared the COBAS(R) acetaminophen and salicylate assays (Roche Diagnostics) with the Stanbio GDS assays (Stanbio Laboratories) that are currently used in our laboratory with respect to interferences from hemolysis and lipemia." | 3.74 | Effects of hemolysis and lipemia on the COBAS salicylate and acetaminophen assays compared to GDS assays. ( Clarke, W; Meany, D; Schowinsky, J, 2008) |
| " Hemolysis, urate, ascorbate, and acetaminophen interfered by > 5%." | 3.68 | Laboratory evaluation of the Glucocard blood glucose test meter. ( Lewis, BD, 1992) |
| "Paracetamol is widely available and has an excellent safety profile; if a renoprotective effect is demonstrated, this trial will support the administration of regularly dosed paracetamol to all patients with knowlesi malaria." | 2.87 | The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW): study protocol for a randomised controlled trial. ( Anstey, NM; Barber, BE; Chatfield, MD; Cooper, DJ; Dondorp, AM; Grigg, MJ; Piera, KA; Plewes, K; Rajahram, GS; William, T; Yeo, TW, 2018) |
| "Sepsis is a heterogeneous clinical syndrome that is complicated commonly by acute kidney injury (sepsis-AKI)." | 2.66 | The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury. ( Kerchberger, VE; Ware, LB, 2020) |
| "Fever and concomitant infection, through an increment of erythrocyte glutathione depletion, sensitized the infant to the haemolytic event." | 1.37 | Acute haemolytic crisis due to concomitant presence of infection and possible altered acetaminophen catabolism in a Philipino child carrying the G6PD-Vanua Lava mutation. ( Capoluongo, E; Concolino, P; De Luca, D; Giardina, B; Maurizi, P; Minucci, A; Torti, E; Zuppi, C, 2011) |
| "Increased hemolysis was observed by Na-salicylate, naproxen and ketorolac at therapeutic and higher concentrations, and by diclofenac and tiaprofenic acid at high concentrations, while the others seemed to stabilize the membrane at the same conditions." | 1.31 | In vitro effects of NSAIDS and paracetamol on oxidative stress-related parameters of human erythrocytes. ( Orhan, H; Sahin, G, 2001) |
| "Acetaminophen was the most likely cause of the hemolysis." | 1.31 | Hemolysis as a potential complication of acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency. ( Sklar, GE, 2002) |
| "No haemolysis was caused by the given dose of the drug." | 1.29 | [Effect of paracetamol on the acid hemolysis of erythrocytes, with special reference to the intracellular glutathione level]. ( Altorjay, I; Balla, G; Dalmi, L; Imre, S; Sári, B, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (23.33) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 5 (16.67) | 29.6817 |
| 2010's | 9 (30.00) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Cooper, DJ | 2 |
| Grigg, MJ | 2 |
| Plewes, K | 2 |
| Rajahram, GS | 2 |
| Piera, KA | 2 |
| William, T | 2 |
| Menon, J | 1 |
| Koleth, G | 1 |
| Edstein, MD | 1 |
| Birrell, GW | 1 |
| Wattanakul, T | 1 |
| Tarning, J | 1 |
| Patel, A | 1 |
| Wen Yeo, T | 1 |
| Dondorp, AM | 2 |
| Anstey, NM | 2 |
| Barber, BE | 2 |
| Bauer-Rusek, S | 1 |
| Samra, N | 1 |
| Moore, SS | 1 |
| Arnon, S | 1 |
| Kerchberger, VE | 1 |
| Ware, LB | 1 |
| Alpaslan, D | 1 |
| Dudu, TE | 1 |
| Aktaş, N | 1 |
| Tahernejad-Javazmi, F | 1 |
| Shabani-Nooshabadi, M | 1 |
| Karimi-Maleh, H | 1 |
| Chatfield, MD | 1 |
| Yeo, TW | 1 |
| Chan, BY | 1 |
| Tsang, HM | 1 |
| Ng, CW | 1 |
| Ling, WH | 1 |
| Leung, DC | 1 |
| Lee, HH | 1 |
| Mak, CM | 1 |
| Zhang, YV | 1 |
| Fan, SL | 1 |
| Kellogg, MD | 1 |
| Simpson, SA | 1 |
| Zaccagni, H | 1 |
| Bichell, DP | 1 |
| Christian, KG | 1 |
| Mettler, BA | 1 |
| Donahue, BS | 1 |
| Roberts, LJ | 1 |
| Pretorius, M | 1 |
| Rickner, SS | 1 |
| Cao, D | 1 |
| Simpson, SE | 1 |
| Amzal, H | 1 |
| Alaoui, K | 1 |
| Tok, S | 1 |
| Errachidi, A | 1 |
| Charof, R | 1 |
| Cherrah, Y | 1 |
| Benjouad, A | 1 |
| Meany, D | 1 |
| Schowinsky, J | 1 |
| Clarke, W | 1 |
| Minucci, A | 1 |
| De Luca, D | 1 |
| Torti, E | 1 |
| Concolino, P | 1 |
| Maurizi, P | 1 |
| Giardina, B | 1 |
| Zuppi, C | 1 |
| Capoluongo, E | 1 |
| Mullins, ME | 1 |
| Vitkovitsky, IV | 1 |
| Ghassabian, S | 1 |
| Wright, LA | 1 |
| Dejager, AD | 1 |
| Smith, MT | 1 |
| SILVERBERG, M | 1 |
| DESFORGES, J | 1 |
| GELLIS, S | 1 |
| Beutler, E | 1 |
| Bartsocas, CS | 1 |
| Schulman, JD | 1 |
| Corash, L | 1 |
| Altorjay, I | 2 |
| Sári, B | 2 |
| Imre, S | 2 |
| Balla, G | 2 |
| Dalmi, L | 2 |
| Wright, RO | 1 |
| Perry, HE | 1 |
| Woolf, AD | 1 |
| Shannon, MW | 1 |
| Orhan, H | 1 |
| Sahin, G | 1 |
| Oliver, M | 1 |
| Coton, T | 1 |
| Badens, C | 1 |
| Dehan, C | 1 |
| Lena-Russo, D | 1 |
| Moalic, JL | 1 |
| Sklar, GE | 1 |
| Manor, E | 1 |
| Marmor, A | 1 |
| Kaufman, S | 1 |
| Leiba, H | 1 |
| Mitchell, JR | 1 |
| Jollows, DJ | 1 |
| Lewis, BD | 1 |
| Campbell, RS | 1 |
| Price, CP | 1 |
| Hennigar, GR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria: A Randomised Controlled Clinical Trial[NCT03056391] | Phase 3 | 360 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Effect of Acetaminophen on the Incidence of Acute Kidney Injury in Patients Undergoing Aortic Surgery With Moderate Hypothermic Circulatory Arrest[NCT04882202] | 136 participants (Anticipated) | Interventional | 2021-09-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for acetaminophen and Hemolysis
| Article | Year |
|---|---|
The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury.
Topics: Acetaminophen; Acute Kidney Injury; Anemia, Sickle Cell; Animals; Coronary Artery Bypass; Disseminat | 2020 |
Hemolysis after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; H | 1996 |
3 trials available for acetaminophen and Hemolysis
| Article | Year |
|---|---|
The Effect of Regularly Dosed Acetaminophen vs No Acetaminophen on Renal Function in Plasmodium knowlesi Malaria (PACKNOW): A Randomized, Controlled Trial.
Topics: Acetaminophen; Acute Kidney Injury; Creatinine; Hemoglobins; Hemolysis; Humans; Kidney; Malaria; Mal | 2022 |
The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW): study protocol for a randomised controlled trial.
Topics: Acetaminophen; Acute Kidney Injury; Antioxidants; Biomarkers; Hemolysis; Humans; Malaria; Malaysia; | 2018 |
Acetaminophen attenuates lipid peroxidation in children undergoing cardiopulmonary bypass.
Topics: Acetaminophen; Acute Kidney Injury; Acute-Phase Proteins; Analgesics, Non-Narcotic; Biomarkers; Card | 2014 |
25 other studies available for acetaminophen and Hemolysis
| Article | Year |
|---|---|
Paracetamol Treatment for Patent Ductus Arteriosus, an Apparent Association with Acute Hemolysis in Three Preterm Infants: Case Series.
Topics: Acetaminophen; Ductus Arteriosus, Patent; Hemolysis; Humans; Ibuprofen; Infant, Newborn; Infant, Pre | 2022 |
Synthesis and characterization of novel organo-hydrogel based agar, glycerol and peppermint oil as a natural drug carrier/release material.
Topics: Acetaminophen; Agar; Antioxidants; Blood Coagulation; Carboplatin; Drug Carriers; Drug Liberation; G | 2021 |
Analysis of glutathione in the presence of acetaminophen and tyrosine via an amplified electrode with MgO/SWCNTs as a sensor in the hemolyzed erythrocyte.
Topics: Acetaminophen; Aniline Compounds; Electrochemical Techniques; Electrodes; Erythrocytes; Glutathione; | 2018 |
Performance evaluation of five commercial assays for detection of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Bilirubin; Hemolysis; Humans; Immunoenzyme Techniques; Linear Models; | 2019 |
Effect of hemolysis, icterus, and lipemia on three acetaminophen assays: Potential medical consequences of false positive results.
Topics: Acetaminophen; False Positive Reactions; Hemolysis; Humans; Hyperlipidemias; Jaundice | 2018 |
Hemolytic crisis following acetaminophen overdose in a patient with G6PD deficiency.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anemia, Hemolytic; Drug Overdose; Female; Glucosepho | 2017 |
Protective effect of saponins from Argania spinosa against free radical-induced oxidative haemolysis.
Topics: Acetaminophen; Animals; Aspirin; Cells, Cultured; Erythrocytes; Free Radicals; Hemoglobins; Hemolysi | 2008 |
Effects of hemolysis and lipemia on the COBAS salicylate and acetaminophen assays compared to GDS assays.
Topics: Acetaminophen; Biological Assay; Hemolysis; Humans; Hyperlipidemias; Reproducibility of Results; Sal | 2008 |
Acute haemolytic crisis due to concomitant presence of infection and possible altered acetaminophen catabolism in a Philipino child carrying the G6PD-Vanua Lava mutation.
Topics: Acetaminophen; Child, Preschool; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Defi | 2011 |
Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Female; Hemolysis; Hemolytic-Uremic Syndr | 2011 |
Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Diazomethane; Drug Stability; Etidronic Acid; H | 2012 |
MECHANISMS UNDERLYING VITAMIN K INDUCED HYPERBILIRUBINEMIA IN PREMATURE INFANTS.
Topics: Acetaminophen; Acetanilides; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Bilirubin; Erythroc | 1963 |
Acetamonophen and G-6-PD deficiency.
Topics: Acetaminophen; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans | 1984 |
Can acetaminophen cause hemolysis in G6PD deficiency?
Topics: Acetaminophen; Adult; Anemia, Hemolytic; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Human | 1982 |
[Effect of paracetamol on the acid hemolysis of erythrocytes, with special reference to the intracellular glutathione level].
Topics: Acetaminophen; Acids; Erythrocytes; Glutathione; Hemolysis; Humans | 1993 |
In vitro effects of NSAIDS and paracetamol on oxidative stress-related parameters of human erythrocytes.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Catalase; Erythrocyte Membrane | 2001 |
Homozygous G6PD deficiency and propacetamol induced hemolysis.
Topics: Acetaminophen; Adult; Anemia, Hemolytic; Anti-Inflammatory Agents, Non-Steroidal; Female; Glucosepho | 2001 |
Hemolysis as a potential complication of acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Cell Count; Glucosephosphate Dehydrogenase Def | 2002 |
Massive hemolysis caused by acetaminophen. Positive determination by direct Coombs test.
Topics: Acetaminophen; Adult; Anemia, Hemolytic; Coombs Test; Hemolysis; Humans; Male | 1976 |
Progress in hepatology. Metabolic activation of drugs to toxic substances.
Topics: Acetaminophen; Animals; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Chemical Pheno | 1975 |
The effect of silibinin (Legalon) on the the free radical scavenger mechanisms of human erythrocytes in vitro.
Topics: Acetaminophen; Adult; Doxorubicin; Erythrocytes; Free Radical Scavengers; Glutathione; Glutathione P | 1992 |
Laboratory evaluation of the Glucocard blood glucose test meter.
Topics: Acetaminophen; Ascorbic Acid; Blood Glucose; Blood Glucose Self-Monitoring; Capillaries; Electrochem | 1992 |
Glucose-6-phosphate dehydrogenase deficiency.
Topics: Acetaminophen; Dapsone; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans | 1991 |
Experience with an homogeneous immunoassay for paracetamol (acetaminophen).
Topics: Acetaminophen; Antidotes; Hemolysis; Humans; Immunoenzyme Techniques; Indicators and Reagents; Kidne | 1986 |
Iatrogenic drug toxicity.
Topics: Acetaminophen; Age Factors; Amphotericin B; Chemical and Drug Induced Liver Injury; Drug Interaction | 1985 |