Page last updated: 2024-10-22

acetaminophen and Heart Diseases

acetaminophen has been researched along with Heart Diseases in 19 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.

Research Excerpts

ExcerptRelevanceReference
" One from a heart disease study and another from acetaminophen (an analgesic) exposure in rat liver that causes centrilobular necrosis."3.74Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes. ( Bushel, PR; Gibson, G; Wolfinger, RD, 2007)
"The close-to-normal AUC, during low cardiac output, despite lower peak paracetamol, shows absorption was not suppressed, only delayed, because of decreased pyloric motility."2.69Intestinal absorption in patients after cardiac surgery. ( Berger, MM; Berger-Gryllaki, M; Cayeux, C; Chioléro, R; Hurni, M; Revelly, JP; Tappy, L; Wiesel, PH, 2000)
" Although effective, these agents can be associated with adverse effects that may limit their use in some people."2.58Cardiorenal Safety of OTC Analgesics. ( Angiolillo, DJ; Davidson, MH; Kloner, RA; White, WB, 2018)
"In celecoxib-treated zebrafish embryos, the heart failed to undergo normal looping and the heart valve was absent, causing serious blood regurgitation."1.37Celecoxib impairs heart development via inhibiting cyclooxygenase-2 activity in zebrafish embryos. ( Bu, JW; Du, JL; Gu, SY; Wang, YW; Xia, YM; Xu, DJ, 2011)
"To understand the bioavailability and mechanistic pathways of cytoprotection by IH636 grape seed proanthocyanidin extract (GSPE, commercially known as ActiVin) a series of in vitro and in vivo studies were conducted."1.31Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. ( Bagchi, D; Bagchi, M; Preuss, HG; Ray, SD; Stohs, SJ, 2002)
" The results of these studies demonstrated that CS-mediated protection is not selective for a particular species, organ system or toxic chemical."1.30Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine. ( Fariss, MW; Lippman, HR; Mumaw, VR; Ray, SD, 1997)
"Acetaminophen was included in the studies as an example of an analgesic agent which lacks anti-inflammatory efficacy."1.28Effects of ibuprofen on doxorubicin toxicity. ( Inchiosa, MA; Smith, CM, 1990)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19904 (21.05)18.7374
1990's6 (31.58)18.2507
2000's6 (31.58)29.6817
2010's3 (15.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
White, WB1
Kloner, RA1
Angiolillo, DJ1
Davidson, MH1
Contractor, H1
Gauge, V1
Nabi, S1
Titu, H1
Arya, S1
Naqvi, N1
Xu, DJ1
Bu, JW1
Gu, SY1
Xia, YM1
Du, JL1
Wang, YW1
Bagchi, D2
Ray, SD3
Bagchi, M1
Preuss, HG1
Stohs, SJ1
Walker, EM1
Epling, CP1
Parris, C1
Cansino, S1
Ghosh, P1
Desai, DH1
Morrison, RG1
Wright, GL1
Wehner, P1
Mangiarua, EI1
Walker, SM1
Blough, ER1
Bushel, PR1
Wolfinger, RD1
Gibson, G1
Prescott, LF2
Barraclough, CJ1
Lowe, RA1
Lip, GY1
Vale, JA1
Brent, J1
Smilkstein, MJ1
Fariss, MW1
Lippman, HR1
Mumaw, VR1
Jones, AL1
Berger, MM1
Berger-Gryllaki, M1
Wiesel, PH1
Revelly, JP1
Hurni, M1
Cayeux, C1
Tappy, L1
Chioléro, R1
Patel, D1
Wong, V1
Inchiosa, MA1
Smith, CM1
Maclean, D1
Peters, TJ1
Brown, RA1
McCathie, M1
Baines, GF1
Robertson, PG1
Sanerkin, NG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Optimal Method of Pain Control After Minimally Invasive Coronary Artery Bypass Grafting[NCT01770236]Phase 441 participants (Actual)Interventional2013-01-31Terminated (stopped due to Study medication no longer available at institution)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for acetaminophen and Heart Diseases

ArticleYear
Cardiorenal Safety of OTC Analgesics.
    Journal of cardiovascular pharmacology and therapeutics, 2018, Volume: 23, Issue:2

    Topics: Acetaminophen; Analgesics; Drug Labeling; Heart Diseases; Humans; Ibuprofen; Kidney Diseases; Naprox

2018
Paracetamol overdosage. Pharmacological considerations and clinical management.
    Drugs, 1983, Volume: 25, Issue:3

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Interactions; Glutathione; Hear

1983
Does acetaminophen damage the heart?
    Journal of toxicology. Clinical toxicology, 1996, Volume: 34, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Electrocardiography; Heart; Heart Diseases;

1996
Unusual complications of paracetamol poisoning.
    QJM : monthly journal of the Association of Physicians, 1997, Volume: 90, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Animals; Esophageal and Gastric Varice

1997

Trials

1 trial available for acetaminophen and Heart Diseases

ArticleYear
Intestinal absorption in patients after cardiac surgery.
    Critical care medicine, 2000, Volume: 28, Issue:7

    Topics: Acetaminophen; Aged; Analysis of Variance; APACHE; Body Mass Index; Cardiac Output, Low; Critical Ca

2000

Other Studies

14 other studies available for acetaminophen and Heart Diseases

ArticleYear
ST segment elevation secondary to paracetamol overdose.
    Therapeutic advances in cardiovascular disease, 2011, Volume: 5, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Aged; Analgesics, Non-Narcotic; Antidotes; Coronary Angiography; Drug

2011
Celecoxib impairs heart development via inhibiting cyclooxygenase-2 activity in zebrafish embryos.
    Anesthesiology, 2011, Volume: 114, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Celecoxib; Cyclooxygenase 2;

2011
Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract.
    Indian journal of experimental biology, 2002, Volume: 40, Issue:6

    Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Analgesics, Non-Narcotic; Ani

2002
Acetaminophen protects against iron-induced cardiac damage in gerbils.
    Annals of clinical and laboratory science, 2007,Winter, Volume: 37, Issue:1

    Topics: Acetaminophen; Administration, Oral; Analysis of Variance; Animals; Body Weight; Echocardiography; G

2007
Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes.
    BMC systems biology, 2007, Feb-23, Volume: 1

    Topics: Acetaminophen; Algorithms; Animals; Clinical Chemistry Tests; Cluster Analysis; Data Interpretation,

2007
Failure of naloxone to reverse the cardiotoxocity of Distalgesic overdose.
    Postgraduate medical journal, 1982, Volume: 58, Issue:684

    Topics: Acetaminophen; Adolescent; Dextropropoxyphene; Drug Combinations; Heart Diseases; Humans; Male; Nalo

1982
New ways of looking at an old molecule.
    Journal of toxicology. Clinical toxicology, 1996, Volume: 34, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Electrocardiography; Heart; Heart Diseases;

1996
APAP-induced heart injury? Maybe yes, maybe no. Next question?
    Journal of toxicology. Clinical toxicology, 1996, Volume: 34, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Electrocardiography; Heart; Heart Diseases; Humans

1996
Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.
    Toxicology letters, 1997, Feb-07, Volume: 90, Issue:2-3

    Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Ch

1997
N-acetylcysteine.
    Alternative medicine review : a journal of clinical therapeutic, 2000, Volume: 5, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Antidotes; Expectorants; Heart Diseases; Humans; Neoplasms; Respirato

2000
In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract.
    Research communications in molecular pathology and pharmacology, 2000, Volume: 107, Issue:1-2

    Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Animals; Antioxidants; Apopto

2000
Effects of ibuprofen on doxorubicin toxicity.
    Research communications in chemical pathology and pharmacology, 1990, Volume: 67, Issue:1

    Topics: Acetaminophen; Actomyosin; Adenosine Triphosphatases; Animals; Anti-Inflammatory Agents, Non-Steroid

1990
Treatment of acute paracetamol poisoning.
    Lancet (London, England), 1968, Oct-19, Volume: 2, Issue:7573

    Topics: Acetaminophen; Adult; Blood Protein Disorders; Brain Edema; Chemical and Drug Induced Liver Injury;

1968
Acute myocardial necrosis in paracetamol poisoning.
    British medical journal, 1971, Volume: 3, Issue:5772

    Topics: Acetaminophen; Adolescent; Female; Heart Diseases; Humans; Necrosis

1971