acetaminophen has been researched along with Heart Diseases in 19 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One from a heart disease study and another from acetaminophen (an analgesic) exposure in rat liver that causes centrilobular necrosis." | 3.74 | Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes. ( Bushel, PR; Gibson, G; Wolfinger, RD, 2007) |
| "The close-to-normal AUC, during low cardiac output, despite lower peak paracetamol, shows absorption was not suppressed, only delayed, because of decreased pyloric motility." | 2.69 | Intestinal absorption in patients after cardiac surgery. ( Berger, MM; Berger-Gryllaki, M; Cayeux, C; Chioléro, R; Hurni, M; Revelly, JP; Tappy, L; Wiesel, PH, 2000) |
| " Although effective, these agents can be associated with adverse effects that may limit their use in some people." | 2.58 | Cardiorenal Safety of OTC Analgesics. ( Angiolillo, DJ; Davidson, MH; Kloner, RA; White, WB, 2018) |
| "In celecoxib-treated zebrafish embryos, the heart failed to undergo normal looping and the heart valve was absent, causing serious blood regurgitation." | 1.37 | Celecoxib impairs heart development via inhibiting cyclooxygenase-2 activity in zebrafish embryos. ( Bu, JW; Du, JL; Gu, SY; Wang, YW; Xia, YM; Xu, DJ, 2011) |
| "To understand the bioavailability and mechanistic pathways of cytoprotection by IH636 grape seed proanthocyanidin extract (GSPE, commercially known as ActiVin) a series of in vitro and in vivo studies were conducted." | 1.31 | Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. ( Bagchi, D; Bagchi, M; Preuss, HG; Ray, SD; Stohs, SJ, 2002) |
| " The results of these studies demonstrated that CS-mediated protection is not selective for a particular species, organ system or toxic chemical." | 1.30 | Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine. ( Fariss, MW; Lippman, HR; Mumaw, VR; Ray, SD, 1997) |
| "Acetaminophen was included in the studies as an example of an analgesic agent which lacks anti-inflammatory efficacy." | 1.28 | Effects of ibuprofen on doxorubicin toxicity. ( Inchiosa, MA; Smith, CM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| White, WB | 1 |
| Kloner, RA | 1 |
| Angiolillo, DJ | 1 |
| Davidson, MH | 1 |
| Contractor, H | 1 |
| Gauge, V | 1 |
| Nabi, S | 1 |
| Titu, H | 1 |
| Arya, S | 1 |
| Naqvi, N | 1 |
| Xu, DJ | 1 |
| Bu, JW | 1 |
| Gu, SY | 1 |
| Xia, YM | 1 |
| Du, JL | 1 |
| Wang, YW | 1 |
| Bagchi, D | 2 |
| Ray, SD | 3 |
| Bagchi, M | 1 |
| Preuss, HG | 1 |
| Stohs, SJ | 1 |
| Walker, EM | 1 |
| Epling, CP | 1 |
| Parris, C | 1 |
| Cansino, S | 1 |
| Ghosh, P | 1 |
| Desai, DH | 1 |
| Morrison, RG | 1 |
| Wright, GL | 1 |
| Wehner, P | 1 |
| Mangiarua, EI | 1 |
| Walker, SM | 1 |
| Blough, ER | 1 |
| Bushel, PR | 1 |
| Wolfinger, RD | 1 |
| Gibson, G | 1 |
| Prescott, LF | 2 |
| Barraclough, CJ | 1 |
| Lowe, RA | 1 |
| Lip, GY | 1 |
| Vale, JA | 1 |
| Brent, J | 1 |
| Smilkstein, MJ | 1 |
| Fariss, MW | 1 |
| Lippman, HR | 1 |
| Mumaw, VR | 1 |
| Jones, AL | 1 |
| Berger, MM | 1 |
| Berger-Gryllaki, M | 1 |
| Wiesel, PH | 1 |
| Revelly, JP | 1 |
| Hurni, M | 1 |
| Cayeux, C | 1 |
| Tappy, L | 1 |
| Chioléro, R | 1 |
| Patel, D | 1 |
| Wong, V | 1 |
| Inchiosa, MA | 1 |
| Smith, CM | 1 |
| Maclean, D | 1 |
| Peters, TJ | 1 |
| Brown, RA | 1 |
| McCathie, M | 1 |
| Baines, GF | 1 |
| Robertson, PG | 1 |
| Sanerkin, NG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Optimal Method of Pain Control After Minimally Invasive Coronary Artery Bypass Grafting[NCT01770236] | Phase 4 | 41 participants (Actual) | Interventional | 2013-01-31 | Terminated (stopped due to Study medication no longer available at institution) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for acetaminophen and Heart Diseases
| Article | Year |
|---|---|
Cardiorenal Safety of OTC Analgesics.
Topics: Acetaminophen; Analgesics; Drug Labeling; Heart Diseases; Humans; Ibuprofen; Kidney Diseases; Naprox | 2018 |
Paracetamol overdosage. Pharmacological considerations and clinical management.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Interactions; Glutathione; Hear | 1983 |
Does acetaminophen damage the heart?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Electrocardiography; Heart; Heart Diseases; | 1996 |
Unusual complications of paracetamol poisoning.
Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Animals; Esophageal and Gastric Varice | 1997 |
1 trial available for acetaminophen and Heart Diseases
| Article | Year |
|---|---|
Intestinal absorption in patients after cardiac surgery.
Topics: Acetaminophen; Aged; Analysis of Variance; APACHE; Body Mass Index; Cardiac Output, Low; Critical Ca | 2000 |
14 other studies available for acetaminophen and Heart Diseases
| Article | Year |
|---|---|
ST segment elevation secondary to paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Aged; Analgesics, Non-Narcotic; Antidotes; Coronary Angiography; Drug | 2011 |
Celecoxib impairs heart development via inhibiting cyclooxygenase-2 activity in zebrafish embryos.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Celecoxib; Cyclooxygenase 2; | 2011 |
Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Analgesics, Non-Narcotic; Ani | 2002 |
Acetaminophen protects against iron-induced cardiac damage in gerbils.
Topics: Acetaminophen; Administration, Oral; Analysis of Variance; Animals; Body Weight; Echocardiography; G | 2007 |
Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes.
Topics: Acetaminophen; Algorithms; Animals; Clinical Chemistry Tests; Cluster Analysis; Data Interpretation, | 2007 |
Failure of naloxone to reverse the cardiotoxocity of Distalgesic overdose.
Topics: Acetaminophen; Adolescent; Dextropropoxyphene; Drug Combinations; Heart Diseases; Humans; Male; Nalo | 1982 |
New ways of looking at an old molecule.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Overdose; Electrocardiography; Heart; Heart Diseases; | 1996 |
APAP-induced heart injury? Maybe yes, maybe no. Next question?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Electrocardiography; Heart; Heart Diseases; Humans | 1996 |
Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Ch | 1997 |
N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Expectorants; Heart Diseases; Humans; Neoplasms; Respirato | 2000 |
In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Animals; Antioxidants; Apopto | 2000 |
Effects of ibuprofen on doxorubicin toxicity.
Topics: Acetaminophen; Actomyosin; Adenosine Triphosphatases; Animals; Anti-Inflammatory Agents, Non-Steroid | 1990 |
Treatment of acute paracetamol poisoning.
Topics: Acetaminophen; Adult; Blood Protein Disorders; Brain Edema; Chemical and Drug Induced Liver Injury; | 1968 |
Acute myocardial necrosis in paracetamol poisoning.
Topics: Acetaminophen; Adolescent; Female; Heart Diseases; Humans; Necrosis | 1971 |