acetaminophen and HbS Disease studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Research Excerpts

Excerpt	Relevance	Reference
"He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated."	5.34	Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007)
" The mean total cumulative morphine dosing was 0."	3.01	Does Intravenous Acetaminophen Reduce Opioid Requirement in Pediatric Emergency Department Patients With Acute Sickle Cell Crises? ( Dhebaria, T; Sivitz, A; Tejani, C, 2021)
"Sepsis is a heterogeneous clinical syndrome that is complicated commonly by acute kidney injury (sepsis-AKI)."	2.66	The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury. ( Kerchberger, VE; Ware, LB, 2020)
"Evaluate the efficiency of the treatment of pain by analgesic according to World Health Organization (WHO)."	1.35	[Treatment of sickle cell pain]. ( Coulibaly, Y; Dembele, A; Diakite, AA; Dicko-Traore, F; Keita, MM; Sidibe, T; Sylla, M; Togo, B; Traore, B, 2009)
"He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated."	1.34	Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007)
"The gene for sickle cell disease is carried by 8% of the African-American population in the United States."	1.28	Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992)

Research

Studies (17)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Adverse Effects

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (11.76)	18.7374
1990's	3 (17.65)	18.2507
2000's	5 (29.41)	29.6817
2010's	2 (11.76)	24.3611
2020's	5 (29.41)	2.80

Authors	Studies
Kerchberger, VE	1
Ware, LB	1
Dhebaria, T	1
Sivitz, A	1
Tejani, C	1
Panda, PC	1
Mishra, NR	2
Patra, CS	1
Nayak, BK	1
Panda, SK	1
Kumar, R	1
Tripathy, SK	1
Nasr, LA	1
Haydar, AA	1
Adam, AM	1
Maritim, MC	1
Diakite, AA	1
Coulibaly, Y	1
Dicko-Traore, F	1
Traore, B	1
Togo, B	1
Dembele, A	1
Sylla, M	1
Sidibe, T	1
Keita, MM	1
Taha, HM	1
Rehmani, RS	1
Wong, F	1
Erhan, E	1
Inal, MT	1
Aydinok, Y	1
Balkan, C	1
Yegul, I	1
Agble, YM	1
Séguier-Lipszyc, E	1
de Lagausie, P	1
Benkerrou, M	1
Di Napoli, S	1
Aigrain, Y	1
Sanders, DY	1
Severance, HW	1
Pollack, CV	1
Pegelow, CH	1
Haddock, DR	1
Bonotey-Ahulu, FI	1
Janosi, M	1
Ankra-Badu, G	1
Reid, HA	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Emergency Department Patients With Acute Sickle Cell Crises?[NCT03541980]	Phase 4	71 participants (Actual)	Interventional	2018-02-20	Completed
A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887]	Phase 2	150 participants (Actual)	Interventional	2004-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Rate of adverse effects experienced by patients from opioid administration vs acetaminophen administration (NCT03541980)
Timeframe: 120 minutes

Cumulative Opioid Dosing

Intervention	Participants (Count of Participants)
Intervention	0
Placebo	0

Total dosing of opioid given after initial evaluation in mg/kg (NCT03541980)
Timeframe: 120 minutes

Inpatient Admission

Intervention	mg/kg (Mean)
Intervention	.2
Placebo	.2

Percentage of patients admitted to the inpatient unit for parenteral pain management (NCT03541980)
Timeframe: 120 minutes

Pain Scores

Intervention	Participants (Count of Participants)
Intervention	25
Placebo	21

Scale of 1-10 Pain scale, Min value 1, Max value 10, higher score is worse (NCT03541980)
Timeframe: at disposition

Percentage of the Patients Reporting Satisfaction

Intervention	pain intensity measured on scale 1-10 (Mean)
Intervention	5.5
Placebo	5.2

How satisfied were patients with the management of their pain (NCT03541980)
Timeframe: 120 minutes

Length of Hospitalization

Intervention	percent (Mean)
Intervention	84
Placebo	85

Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days

Number of Participants Discharged to Home Within the First 24 Hours

Number of Participants With Acute Chest Syndrome/Pneumonia Requiring Blood Transfusion

Intervention	Days (Median)
Inhaled Nitric Oxide	4.06
Placebo	3.11

Intervention	Participants (Count of Participants)
Inhaled Nitric Oxide	5
Placebo	7

Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days

Time to Vaso-occlusive Pain Crisis (VOC) Resolution

Intervention	Participants (Count of Participants)
Inhaled Nitric Oxide	8
Placebo	7

"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days

Number of Participants Readmitted to Hospital Within 30 Days After Discharge

Intervention	Hours (Median)
Inhaled Nitric Oxide	61.83
Placebo	55.16

The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up

Total Dose of Opioids Received

Intervention	Participants (Count of Participants)
	during first 24 hours	during 30-day follow-up
Inhaled Nitric Oxide	0	9
Placebo	0	17

The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days

Article	Year
The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury. Seminars in nephrology, 2020, Volume: 40, Issue:2 Topics: Acetaminophen; Acute Kidney Injury; Anemia, Sickle Cell; Animals; Coronary Artery Bypass; Disseminat	2020
Liver and kidney diseases. Clinics in liver disease, 2002, Volume: 6, Issue:4 Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G	2002

Article	Year
Does Intravenous Acetaminophen Reduce Opioid Requirement in Pediatric Emergency Department Patients With Acute Sickle Cell Crises? Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2021, Volume: 28, Issue:6 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Child;	2021
Intravenous Acetaminophen vs Intravenous Diclofenac Sodium in Management of Skeletal Vaso-occlusive Crisis Among Children with Homozygous Sickle Cell Disease: A Randomized Controlled Trial. Indian pediatrics, 2021, 03-15, Volume: 58, Issue:3 Topics: Acetaminophen; Anemia, Sickle Cell; Child; Diclofenac; Double-Blind Method; Humans; Pain Measurement	2021
Thrombosis in sickle-cell pain crises? Controlled trial of ancrod (Arvin) in young adults. The Journal of tropical medicine and hygiene, 1973, Volume: 76, Issue:11 Topics: Acetaminophen; Adolescent; Adult; Ampicillin; Anemia, Sickle Cell; Child; Chloroquine; Female; Fetal	1973

Article	Year
Intravenous Acetaminophen vs Intravenous Diclofenac in the Management of Painful Crisis in Sickle Cell Disease: Authors' Reply. Indian pediatrics, 2021, 05-15, Volume: 58, Issue:5 Topics: Acetaminophen; Administration, Intravenous; Anemia, Sickle Cell; Diclofenac; Humans; Pain	2021
Intravenous Acetaminophen vs Intravenous Diclofenac in the Management of Painful Crisis in Sickle Cell Disease. Indian pediatrics, 2021, 05-15, Volume: 58, Issue:5 Topics: Acetaminophen; Administration, Intravenous; Anemia, Sickle Cell; Diclofenac; Humans; Pain	2021
Plain film signs of sickle β-thalassaemia. Lancet (London, England), 2017, 01-14, Volume: 389, Issue:10065 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anemia, Sickle Cell; beta-Thalassemia; Female; Hemat	2017
Pseudoxanthoma elasticum in a patient with sickle cell disease: case report. East African medical journal, 2008, Volume: 85, Issue:2 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Anti-Bacterial Agents; Cef	2008
[Treatment of sickle cell pain]. Le Mali medical, 2009, Volume: 24, Issue:2 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Child; Female; Humans; Mal	2009
Pain management of children and adolescents with sickle cell disease presenting to the emergency department. Saudi medical journal, 2011, Volume: 32, Issue:2 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Anti-I	2011
Tramadol infusion for the pain management in sickle cell disease: a case report. Paediatric anaesthesia, 2007, Volume: 17, Issue:1 Topics: Abdominal Pain; Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Ch	2007
Management of sickle cell disease. Non-addictive analgesics can be as effective as morphine and pethidine. BMJ (Clinical research ed.), 1998, Mar-21, Volume: 316, Issue:7135 Topics: Acetaminophen; Analgesics, Opioid; Anemia, Sickle Cell; Child; Child, Preschool; Codeine; Drug Combi	1998
Elective laparoscopic cholecystectomy. Surgical endoscopy, 2001, Volume: 15, Issue:3 Topics: Abdominal Pain; Acetaminophen; Acute Disease; Anemia, Sickle Cell; Child; Child, Preschool; Cholecys	2001
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. Southern medical journal, 1992, Volume: 85, Issue:8 Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory	1992
Survey of pain management therapy provided for children with sickle cell disease. Clinical pediatrics, 1992, Volume: 31, Issue:4 Topics: Acetaminophen; Analgesics; Anemia, Sickle Cell; Child; Child, Preschool; Codeine; Drug Administratio	1992
Pain-relief in sickle cell crisis. Lancet (London, England), 1986, Aug-09, Volume: 2, Issue:8502 Topics: Acetaminophen; Analgesics; Anemia, Sickle Cell; Bone and Bones; Child; Humans; Pain; Recurrence	1986

acetaminophen and HbS Disease