acetaminophen has been researched along with Hallux Valgus in 5 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Hallux Valgus: Lateral displacement of the great toe (HALLUX), producing deformity of the first METATARSOPHALANGEAL JOINT with callous, bursa, or BUNION formation over the bony prominence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the safety and satisfaction of patients treated ≤ 14 days after unilateral bunionectomy with extended-release oxycodone/acetaminophen (ER OC/APAP), a biphasic (ER and immediate release) fixed-dose combination analgesic being developed for moderate to severe acute pain." | 5.19 | Assessment of the safety and efficacy of extended-release oxycodone/acetaminophen, for 14 days postsurgery. ( Barrett, T; Kostenbader, K; Singla, N; Sisk, L; Young, J, 2014) |
| " We hypothesized that dexamethasone would reduce the need for oxycodone after surgical correction of hallux valgus." | 5.14 | Dexamethasone decreases oxycodone consumption following osteotomy of the first metatarsal bone: a randomized controlled trial in day surgery. ( Hynynen, MJ; Kalso, E; Kontinen, VK; Mattila, K, 2010) |
| "The surgical treatment of hallux valgus deformity is connected with significant postoperative pain." | 2.80 | [Preemptive local anesthetic infiltration in hallux valgus one-day surgery]. ( Gądek, A; Liszka, H, 2015) |
| " Additional measures included NPRS scores at predefined times over 48 hours, the summed pain intensity difference over 48 hours (SPID48), the time-weighted sum of pain relief scores over the first 8 hours, the mean dosing interval (the time from dosing to the time rescue medication or the next dose of study medication was administered, whichever was less), the proportion of patients requiring rescue medication, and the onset of perceptible and meaningful pain relief (2-stopwatch method)." | 2.74 | Diclofenac potassium liquid-filled soft gelatin capsules in the management of patients with postbunionectomy pain: a Phase III, multicenter, randomized, double-blind, placebo-controlled study conducted over 5 days. ( Boesing, SE; Diamond, E; Duckor, S; Gottlieb, I; Raymond, G; Riff, DS; Soulier, S, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singla, N | 1 |
| Barrett, T | 1 |
| Sisk, L | 1 |
| Kostenbader, K | 1 |
| Young, J | 1 |
| Gądek, A | 1 |
| Liszka, H | 1 |
| Mattila, K | 1 |
| Kontinen, VK | 1 |
| Kalso, E | 1 |
| Hynynen, MJ | 1 |
| Turan, I | 1 |
| Assareh, H | 1 |
| Rolf, C | 1 |
| Jakobsson, JG | 1 |
| Riff, DS | 1 |
| Duckor, S | 1 |
| Gottlieb, I | 1 |
| Diamond, E | 1 |
| Soulier, S | 1 |
| Raymond, G | 1 |
| Boesing, SE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Evaluation of the Safety and Analgesic Efficacy of COV795 in Moderate to Severe Post-Operative Bunionectomy Pain Followed by an Open-Label Extension[NCT01484652] | Phase 3 | 329 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery[NCT00366444] | Phase 3 | 201 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Pain intensity (PI) is measured using the 11-point (0-10) Numeric Pain Rating Scale (NPRS) score. PID is the arithmetic difference in NPRS score at the time point of interest from the baseline score. SPID48 is the sum of time-weighted PID scores measured 22 times over the 48 hour assessment period, with a total score ranging from -480 (worst) to 480 (best). A higher SPID value indicates greater pain relief. (NCT01484652)
Timeframe: 48 hours
| Intervention | scores on a scale (Mean) |
|---|---|
| COV795 | 114.9 |
| Placebo | 66.9 |
Pain intensity scores were measured using an 11-point numerical pain rating scale (NPRS) with 0=no pain to 10=worst possible pain (NCT00366444)
Timeframe: Over 48 hours after bunionectomy
| Intervention | units on a scale (Mean) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 2.5 |
| Placebo | 5.6 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 70.2 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 26.0 |
| Placebo | 22.2 |
(NCT00366444)
Timeframe: Day 1
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 40 |
| Placebo | 87 |
(NCT00366444)
Timeframe: Day 2
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 22 |
| Placebo | 64 |
Day 3 data reflect the use of rescue medication only up to the time of discharge (NCT00366444)
Timeframe: Day 3
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 5 |
| Placebo | 29 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 62 |
| Placebo | 40 |
Times to onset of Perceptible and Meaningful Relief were determined using the double-stopwatch method. (NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 58 |
| Placebo | 35 |
Times to onset of Perceptible and Meaningful Relief were determined using the double-stopwatch method. (NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | participants (Number) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 84 |
| Placebo | 69 |
(NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | minutes (Median) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 60 |
Pain relief was rated using a 5-point categorial scale (0=none, 1=a little, 2=some, 3=a lot, and 4=complete) at time of dose (time=0) and over 15 time points afterwards (10, 15, 20, 30, 45, and 60 minutes and at 1.5, 2, 2.5, 3, 4, 5, 6, 7, and 8 hours after the initial dose on Day 1 or until time of re-medication). A score of 0 across all time points would be the lowest (worst) and a score of 60 (4 X 15 time points) would be the highest (best) possible score. (NCT00366444)
Timeframe: 8 hours post single dose
| Intervention | units on a scale (Mean) |
|---|---|
| Zipsor (Diclofenac Potassium) Liquid Filled Capsule | 8.2 |
| Placebo | 2.6 |
4 trials available for acetaminophen and Hallux Valgus
| Article | Year |
|---|---|
Assessment of the safety and efficacy of extended-release oxycodone/acetaminophen, for 14 days postsurgery.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics, Opioid; Delayed-Action Preparations; | 2014 |
[Preemptive local anesthetic infiltration in hallux valgus one-day surgery].
Topics: Acetaminophen; Ambulatory Surgical Procedures; Anesthesia, Local; Anesthetics, Local; Bupivacaine; H | 2015 |
Dexamethasone decreases oxycodone consumption following osteotomy of the first metatarsal bone: a randomized controlled trial in day surgery.
Topics: Acetaminophen; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Opioid; | 2010 |
Diclofenac potassium liquid-filled soft gelatin capsules in the management of patients with postbunionectomy pain: a Phase III, multicenter, randomized, double-blind, placebo-controlled study conducted over 5 days.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; An | 2009 |
1 other study available for acetaminophen and Hallux Valgus
| Article | Year |
|---|---|
Etoricoxib, paracetamol, and dextropropoxyphene for postoperative pain management: a questionnaire survey of consumption of take-home medication after elective hallux valgus surgery.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Analgesics; Data Collection; Dextropropoxyphene | 2008 |