acetaminophen has been researched along with Genetic Predisposition in 29 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress." | 7.80 | Association between recent acetaminophen use and asthma: modification by polymorphism at TLR4. ( Hong, K; Hong, SJ; Jung, YH; Kang, MJ; Kim, BJ; Kim, HB; Kim, HJ; Kim, HS; Kim, HY; Kim, YJ; Kwon, JW; Lee, SH; Lee, SY; Park, KS; Seo, JH; Yu, HS, 2014) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse mucocutaneous reactions to certain drugs." | 5.42 | Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B*4403 allele and lamotrigine. ( Kim, SR; Koh, BS; Lee, JH; Leem, DW; Moon, IJ; Park, HJ; Park, JW; Park, KH, 2015) |
| "The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress." | 3.80 | Association between recent acetaminophen use and asthma: modification by polymorphism at TLR4. ( Hong, K; Hong, SJ; Jung, YH; Kang, MJ; Kim, BJ; Kim, HB; Kim, HJ; Kim, HS; Kim, HY; Kim, YJ; Kwon, JW; Lee, SH; Lee, SY; Park, KS; Seo, JH; Yu, HS, 2014) |
| "Acetaminophen has been associated with asthma and is in part metabolised via the glutathione pathway." | 3.76 | Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort. ( Ali, D; Barr, RG; Chew, GL; Garfinkel, RS; Goldstein, IF; Miller, RL; Perera, FP; Perzanowski, MS; Tang, D, 2010) |
| "Ovarian cancer is the leading cause of death from gynaecological malignancy, especially because of late diagnosis." | 2.44 | [Chemoprevention and prophylactic surgery in ovarian carcinoma]. ( Deffieux, X; Faivre, E; Fernandez, H; Frydman, R; Morice, P; Touboul, C; Uzan, C, 2007) |
| " The results of this study suggest a new toxic mechanism of acetaminophen-induced liver injury in patients with acatalasemia." | 1.62 | Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice. ( Eitoku, M; Matsuura-Harada, Y; Nagaoka, K; Ogino, K; Ogino, N; Suganuma, N; Tomizuka, K, 2021) |
| "Acetaminophen (APAP) is a commonly used over-the-counter drug for its analgesic and antipyretic effects." | 1.56 | Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1 ( Chen, L; Manautou, JE; Wang, P; Zhong, XB, 2020) |
| "Pediatric acute-liver-failure due to acetaminophen (APAP) administration at therapeutic dosage is rare, while viral infections and metabolic defects are the prevalent causes." | 1.46 | NBAS mutations cause acute liver failure: when acetaminophen is not a culprit. ( Brunati, A; Calvo, PL; Haak, TB; Olio, DD; Pinon, M; Romagnoli, R; Spada, M; Tandoi, F, 2017) |
| "Acetaminophen (APAP) is a readily available over-the-counter drug and is one of the most commonly used analgesics/antipyretics worldwide." | 1.43 | Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes. ( Claessen, SM; Coonen, ML; Jetten, MJ; Kleinjans, JC; Lommen, A; Peijnenburg, AA; Ruiz-Aracama, A; van Delft, JH; van Herwijnen, MH, 2016) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse mucocutaneous reactions to certain drugs." | 1.42 | Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B*4403 allele and lamotrigine. ( Kim, SR; Koh, BS; Lee, JH; Leem, DW; Moon, IJ; Park, HJ; Park, JW; Park, KH, 2015) |
| " In this situation, newborns might be exposed to toxic levels of morphine when breastfeeding." | 1.34 | Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine. ( Aleksa, K; Cairns, J; Chitayat, D; Gaedigk, A; Karaskov, T; Koren, G; Leeder, JS; Madadi, P; Teitelbaum, R, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 14 (48.28) | 24.3611 |
| 2020's | 6 (20.69) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L | 1 |
| Wang, P | 1 |
| Manautou, JE | 1 |
| Zhong, XB | 1 |
| Monte, AA | 1 |
| Sonn, B | 1 |
| Saben, J | 1 |
| Rumack, BH | 1 |
| Reynolds, KM | 1 |
| Dart, RC | 1 |
| Heard, KJ | 1 |
| Jongkhajornpong, P | 1 |
| Ueta, M | 1 |
| Lekhanont, K | 1 |
| Puangsricharern, V | 1 |
| Prabhasawat, P | 1 |
| Chantaren, P | 1 |
| Pisuchpen, P | 1 |
| Kinoshita, S | 1 |
| Zarubin, A | 1 |
| Stepanov, V | 1 |
| Markov, A | 1 |
| Kolesnikov, N | 1 |
| Marusin, A | 1 |
| Khitrinskaya, I | 1 |
| Swarovskaya, M | 1 |
| Litvinov, S | 1 |
| Ekomasova, N | 1 |
| Dzhaubermezov, M | 1 |
| Maksimova, N | 1 |
| Sukhomyasova, A | 1 |
| Shtygasheva, O | 1 |
| Khusnutdinova, E | 1 |
| Radzhabov, M | 1 |
| Kharkov, V | 1 |
| Naim, S | 1 |
| Fernandez-Marrero, Y | 1 |
| de Brot, S | 1 |
| Bachmann, D | 1 |
| Kaufmann, T | 1 |
| Ogino, N | 1 |
| Nagaoka, K | 1 |
| Tomizuka, K | 1 |
| Matsuura-Harada, Y | 1 |
| Eitoku, M | 1 |
| Suganuma, N | 1 |
| Ogino, K | 1 |
| Calvo, PL | 1 |
| Tandoi, F | 1 |
| Haak, TB | 1 |
| Brunati, A | 1 |
| Pinon, M | 1 |
| Olio, DD | 1 |
| Romagnoli, R | 1 |
| Spada, M | 1 |
| Lewis, TR | 1 |
| Shelton, EL | 1 |
| Van Driest, SL | 1 |
| Kannankeril, PJ | 1 |
| Reese, J | 1 |
| Lee, HC | 1 |
| Liao, CC | 1 |
| Day, YJ | 1 |
| Liou, JT | 1 |
| Li, AH | 1 |
| Liu, FC | 1 |
| Kang, SH | 1 |
| Jung, YH | 2 |
| Kim, HY | 2 |
| Seo, JH | 2 |
| Lee, JY | 1 |
| Kwon, JW | 2 |
| Kim, BJ | 2 |
| Kim, HB | 2 |
| Lee, SY | 2 |
| Jang, GC | 1 |
| Song, DJ | 1 |
| Kim, WK | 1 |
| Shim, JY | 1 |
| Kim, JH | 1 |
| Kang, MJ | 2 |
| Yu, HS | 2 |
| Yu, J | 1 |
| Hong, SJ | 2 |
| Liu, LY | 1 |
| Fox, CS | 1 |
| North, TE | 1 |
| Goessling, W | 1 |
| Lee, SH | 1 |
| Hong, K | 1 |
| Kim, HJ | 1 |
| Kim, YJ | 1 |
| Kim, HS | 1 |
| Park, KS | 1 |
| Park, HJ | 1 |
| Kim, SR | 1 |
| Leem, DW | 1 |
| Moon, IJ | 1 |
| Koh, BS | 1 |
| Park, KH | 1 |
| Park, JW | 1 |
| Lee, JH | 1 |
| Jetten, MJ | 1 |
| Ruiz-Aracama, A | 1 |
| Coonen, ML | 1 |
| Claessen, SM | 1 |
| van Herwijnen, MH | 1 |
| Lommen, A | 1 |
| van Delft, JH | 1 |
| Peijnenburg, AA | 1 |
| Kleinjans, JC | 1 |
| Lu, X | 1 |
| Hu, B | 1 |
| Zheng, J | 1 |
| Ji, C | 1 |
| Fan, X | 1 |
| Gao, Y | 1 |
| Gallo, V | 1 |
| Dijk, FN | 1 |
| Holloway, JW | 1 |
| Ring, SM | 1 |
| Koppelman, GH | 1 |
| Postma, DS | 1 |
| Strachan, DP | 1 |
| Granell, R | 1 |
| de Jongste, JC | 1 |
| Jaddoe, VW | 1 |
| den Dekker, HT | 1 |
| Duijts, L | 1 |
| Henderson, AJ | 1 |
| Shaheen, SO | 1 |
| Harrill, AH | 1 |
| Watkins, PB | 2 |
| Su, S | 1 |
| Ross, PK | 1 |
| Harbourt, DE | 1 |
| Stylianou, IM | 1 |
| Boorman, GA | 1 |
| Russo, MW | 1 |
| Sackler, RS | 1 |
| Harris, SC | 1 |
| Smith, PC | 1 |
| Tennant, R | 1 |
| Bogue, M | 1 |
| Paigen, K | 1 |
| Harris, C | 1 |
| Contractor, T | 1 |
| Wiltshire, T | 1 |
| Rusyn, I | 1 |
| Threadgill, DW | 1 |
| Perzanowski, MS | 1 |
| Miller, RL | 1 |
| Tang, D | 1 |
| Ali, D | 1 |
| Garfinkel, RS | 1 |
| Chew, GL | 1 |
| Goldstein, IF | 1 |
| Perera, FP | 1 |
| Barr, RG | 1 |
| Leeder, JS | 2 |
| Strnad, P | 1 |
| Zhou, Q | 1 |
| Hanada, S | 1 |
| Lazzeroni, LC | 1 |
| Zhong, BH | 1 |
| So, P | 1 |
| Davern, TJ | 1 |
| Lee, WM | 1 |
| Omary, MB | 1 |
| Liss, G | 1 |
| Rattan, S | 1 |
| Lewis, JH | 1 |
| Stirnimann, G | 1 |
| Kessebohm, K | 1 |
| Lauterburg, B | 1 |
| Welch, KD | 2 |
| Reilly, TP | 3 |
| Bourdi, M | 3 |
| Hays, T | 1 |
| Pise-Masison, CA | 1 |
| Radonovich, MF | 1 |
| Brady, JN | 1 |
| Dix, DJ | 1 |
| Pohl, LR | 3 |
| Seeff, LB | 1 |
| Ikeda, T | 1 |
| Eiras, DP | 1 |
| Holt, MP | 1 |
| Webster, MR | 1 |
| Deffieux, X | 1 |
| Touboul, C | 1 |
| Uzan, C | 1 |
| Faivre, E | 1 |
| Frydman, R | 1 |
| Fernandez, H | 1 |
| Morice, P | 1 |
| Madadi, P | 1 |
| Koren, G | 1 |
| Cairns, J | 1 |
| Chitayat, D | 1 |
| Gaedigk, A | 1 |
| Teitelbaum, R | 1 |
| Karaskov, T | 1 |
| Aleksa, K | 1 |
| Elkahloun, AG | 1 |
| George, JW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacogenomics of APAP Induced DILI in Chinese Population.[NCT04964310] | 339 participants (Anticipated) | Observational | 2020-08-31 | Recruiting | |||
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| Liver Injury by Statins in Coronary Heart Disease (CHD) Patients With History of Hepatitis B Virus (HBV) Infection[NCT02808299] | 600 participants (Anticipated) | Observational | 2016-12-31 | Not yet recruiting | |||
| Cells of Monocytic Origin as Surrogate Markers for Individual Drug Effects and Hepatotoxicity[NCT02353455] | 300 participants (Anticipated) | Observational | 2013-03-31 | Recruiting | |||
| A Multi-center, Randomized, Double-blind, Active Control Phase II Study to Investigate Multiple Dosage and Treatments of Magnesium Isoglycyrrhizinate Injection to Cure the Acute Drug-induced Liver Injury[NCT02734966] | Phase 2 | 174 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for acetaminophen and Genetic Predisposition
| Article | Year |
|---|---|
Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment.
Topics: Acetaminophen; Animals; Disease Models, Animal; Ductus Arteriosus, Patent; Genetic Predisposition to | 2018 |
Predicting and preventing acute drug-induced liver injury: what's new in 2010?
Topics: Acetaminophen; Adult; Aged; Aging; Alanine Transaminase; Amoxicillin-Potassium Clavulanate Combinati | 2010 |
Liver injury caused by drugs: an update.
Topics: Acetaminophen; Adaptive Immunity; Analgesics, Non-Narcotic; Antitubercular Agents; Apoptosis; Chemic | 2010 |
[Drug-induced liver injury].
Topics: Acetaminophen; Anesthetics, General; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; | 2006 |
[Chemoprevention and prophylactic surgery in ovarian carcinoma].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Carcinoma; Chemoprevention; Contraceptives, Oral; Evidence- | 2007 |
24 other studies available for acetaminophen and Genetic Predisposition
| Article | Year |
|---|---|
Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1
Topics: Acetaminophen; Cell Line; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Ge | 2020 |
The Genomics of Elevated ALT and Adducts in Therapeutic Acetaminophen Treatment: a Pilot Study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Gene | 2021 |
Association of HLA polymorphisms and acetaminophen-related Steven-Johnson syndrome with severe ocular complications in Thai population.
Topics: Acetaminophen; Case-Control Studies; Genetic Predisposition to Disease; HLA-A Antigens; HLA-B Antige | 2022 |
Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy.
Topics: Acetaminophen; Angiotensin-Converting Enzyme 2; Asia; Basigin; COVID-19; COVID-19 Drug Treatment; Cu | 2020 |
Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; | 2021 |
Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice.
Topics: Acatalasia; Acetaminophen; Animals; Catalase; Chemical and Drug Induced Liver Injury; Gene Expressio | 2021 |
NBAS mutations cause acute liver failure: when acetaminophen is not a culprit.
Topics: Acetaminophen; Diagnosis, Differential; Disease Progression; Fever; Genetic Predisposition to Diseas | 2017 |
IL-17 deficiency attenuates acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Chemotaxis, Leukocyte; C | 2018 |
Effect of paracetamol use on the modification of the development of asthma by reactive oxygen species genes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arylamine N-Acetyltransferase; Asthma; Child; Child, Presch | 2013 |
Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development.
Topics: Acetaminophen; Animals; Ethanol; Gene Expression Regulation, Developmental; Gene Knockdown Technique | 2013 |
Association between recent acetaminophen use and asthma: modification by polymorphism at TLR4.
Topics: Acetaminophen; Adolescent; Asthma; Bronchial Hyperreactivity; Child; Cross-Sectional Studies; Eosino | 2014 |
Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B*4403 allele and lamotrigine.
Topics: Acetaminophen; Acetazolamide; Adult; Aged; Aged, 80 and over; Alleles; Allopurinol; Anti-Bacterial A | 2015 |
Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.
Topics: Acetaminophen; Activation, Metabolic; Analgesics, Non-Narcotic; Cells, Cultured; Chemical and Drug I | 2016 |
Predose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in Rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2015 |
TRPA1 gene polymorphisms and childhood asthma.
Topics: Acetaminophen; Asthma; Child, Preschool; Cohort Studies; Female; Follow-Up Studies; Genetic Associat | 2017 |
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cohort Studies | 2009 |
Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort.
Topics: Acetaminophen; Allergens; Analgesics, Non-Narcotic; Asthma; Child, Preschool; Female; Genetic Predis | 2010 |
Developmental pharmacogenetics: a general paradigm for application to neonatal pharmacology and toxicology.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Benzhydryl Compounds; Environmental Pollutants; Female; Gas | 2009 |
Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asian; Black or African American; Chemical and Drug | 2010 |
Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Genetic | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Drug-induced liver injury: summary of a single topic clinical research conference.
Topics: Acetaminophen; Adult; Analgesics; Chemical and Drug Induced Liver Injury; Child; Genetic Predisposit | 2006 |
Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Antibodies; Arginase; Biomarkers; Chemical and Drug Induced Liver Injury; Di | 2007 |
Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine.
Topics: Acetaminophen; Analgesics, Opioid; Breast Feeding; Codeine; Cytochrome P-450 CYP2D6; Fatal Outcome; | 2007 |
Macrophage migration inhibitory factor in drug-induced liver injury: a role in susceptibility and stress responsiveness.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Biotransformation; Chemical and Drug Induc | 2002 |