acetaminophen has been researched along with Gastrointestinal Hemorrhage in 67 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Fourteen patients with rheumatoid arthritis received equivalent therapeutic doses of the antinflammatory drugs aspirin, 4 gm/day, and fenoprofen calcium, 2." | 9.04 | Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. ( Craig, RM; Culic, DD; Falk, J; Loebl, DH; Ridolfo, AS; Schmid, FR, 1977) |
| "The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure." | 7.96 | Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 6.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| "To compare the incidence of serious adverse clinical events among children <2 years old given ibuprofen and acetaminophen to control fever." | 5.09 | The safety of acetaminophen and ibuprofen among children younger than two years old. ( Lesko, SM; Mitchell, AA, 1999) |
| " Fourteen patients with rheumatoid arthritis received equivalent therapeutic doses of the antinflammatory drugs aspirin, 4 gm/day, and fenoprofen calcium, 2." | 5.04 | Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. ( Craig, RM; Culic, DD; Falk, J; Loebl, DH; Ridolfo, AS; Schmid, FR, 1977) |
| "The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure." | 3.96 | Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020) |
| "A comparison of aspirin and acetaminophen consumption in 346 matched pairs of patients with hematemesis and melena and general population control subjects has shown associations between intake of both drugs and bleeding." | 3.66 | Analgesic intake and the risk of acute upper gastrointestinal bleeding. ( Coggon, D; Langman, MJ; Spiegelhalter, D, 1983) |
| "Ibuprofen was statistically equivalent to paracetamol and better tolerated than aspirin (p <0." | 2.70 | Comparative tolerability of paracetamol, aspirin and ibuprofen for short-term analgesia in patients with musculoskeletal conditions: results in 4291 patients. ( Le Parc, JM; Moore, N; Schneid, H; Van Ganse, E; Verrière, F; Wall, R, 2002) |
| "(R)- flurbiprofen was not statistically significant." | 2.69 | Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial. ( Caubet, JF; Handley, DA; Jerussi, TP; McCray, JE, 1998) |
| "Aspirin alone was used as a positive control." | 2.66 | Effects of aspirin and an aspirin-acetaminophen combination on the gastric mucosa in normal subjects. A double-blind endoscopic study. ( Graham, DY; Smith, JL, 1985) |
| "We conducted a systematic literature review to assess the adverse event (AE) profile of paracetamol." | 2.53 | Paracetamol: not as safe as we thought? A systematic literature review of observational studies. ( Bernstein, I; Birrell, F; Buckner, S; Conaghan, PG; Constanti, M; Delgado Nunes, V; Doherty, M; Dziedzic, K; Latchem, S; Miller, P; Porcheret, M; Roberts, E; Wise, E; Zhang, W, 2016) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 2.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| "Paracetamol is classically considered as a very safe analgesic/antipyretic compound and, more specifically, as being virtually devoid of any gastrointestinal (GI) ulcerogenic potential." | 2.42 | Gastrointestinal safety of paracetamol: is there any cause for concern? ( Bannwarth, B, 2004) |
| " Some of the newer NSAIDs seem at normal dosage to be far less damaging than traditional ASA or indomethacin." | 2.37 | Gastroduodenal damage due to drugs, alcohol and smoking. ( Domschke, S; Domschke, W, 1984) |
| "Acetaminophen is an effective antipyretic and analgesic with few side effects that is toxic only in massive overdose." | 2.36 | Use of antipyretic analgesics in the pediatric patient. ( Gladtke, E, 1983) |
| "Chronic gastric ulcer is linked to aspirin intake in patients with rheumatic disease, and epidemiologically in all heavy aspirin users; paradoxically, in only one epidemiologic study was a significant association found between acetaminophen intake and chronic gastric ulcer." | 2.36 | Gastrointestinal effects of antipyretic analgesics. ( Ivey, KJ, 1983) |
| "In physical examination features of upper respiratory tract infection were shown." | 1.35 | [Twenty-two months old girl with haemorrhagic gastritis as a complication after the nonsteroid anti-inflammatory drugs application--case report]. ( Jakubczyk, M; Mierzwa, G; Parzecka, M; Popławski, C; Swincow, G, 2008) |
| "Ibuprofen users also were somewhat less likely (31% vs 37%) to report GI pain at admission, but among hospitalized patients with endoscopic examinations were more likely (75% vs 58%) to be diagnosed with ulcer or hematemesis vs normal or gastritis/dyspepsia/reflux." | 1.32 | Outcome of upper gastro-intestinal bleeding and use of ibuprofen versus paracetamol. ( Blot, WJ; DuBois, R; Fischer, T; Friis, S; Lipworth, L; McLaughlin, JK; Mumma, M; Nielsen, GL; Sørensen, HT, 2004) |
| "A patient is described where oesophageal varices developed and bled 13 days after a paracetamol overdose." | 1.28 | Fatal variceal haemorrhage after paracetamol overdose. ( Losowsky, MS; Thornton, JR, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (43.28) | 18.7374 |
| 1990's | 8 (11.94) | 18.2507 |
| 2000's | 19 (28.36) | 29.6817 |
| 2010's | 9 (13.43) | 24.3611 |
| 2020's | 2 (2.99) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, C | 1 |
| Meng, F | 1 |
| Wu, H | 1 |
| Wu, W | 1 |
| Karpińska, G | 1 |
| Dobrowolski, JC | 1 |
| Yinda, CK | 1 |
| Rector, A | 1 |
| Zeller, M | 1 |
| Conceição-Neto, N | 1 |
| Heylen, E | 1 |
| Maes, P | 1 |
| Ghogomu, SM | 1 |
| Van Ranst, M | 1 |
| Matthijnssens, J | 1 |
| Arthanari, SK | 1 |
| Vanitha, J | 1 |
| Ganesh, M | 1 |
| Venkateshwaran, K | 1 |
| de Lama Caro-Patón, G | 1 |
| García-Salido, A | 1 |
| Iglesias-Bouzas, MI | 1 |
| Guillén, M | 1 |
| Cañedo-Villaroya, E | 1 |
| Martínez-Romera, I | 1 |
| Serrano-González, A | 1 |
| Casado-Flores, J | 1 |
| Gale, P | 2 |
| Chen, X | 2 |
| Li, H | 1 |
| Lucero-Prisno, DE | 1 |
| Abdullah, AS | 1 |
| Huang, J | 1 |
| Laurence, C | 1 |
| Liang, X | 1 |
| Ma, Z | 1 |
| Mao, Z | 1 |
| Ren, R | 1 |
| Wu, S | 1 |
| Wang, N | 1 |
| Wang, P | 2 |
| Wang, T | 1 |
| Yan, H | 1 |
| Zou, Y | 1 |
| Olsen, KM | 1 |
| Gabler, NK | 1 |
| Rademacher, CJ | 1 |
| Schwartz, KJ | 1 |
| Schweer, WP | 1 |
| Gourley, GG | 1 |
| Patience, JF | 1 |
| Rauch, JC | 1 |
| Stokes, RS | 1 |
| Shike, DW | 1 |
| Luebbe, KM | 1 |
| Stalker, LA | 1 |
| Klopfenstein, TJ | 1 |
| Funston, RN | 1 |
| Unger, PA | 1 |
| Lighaam, LC | 1 |
| Vermeulen, E | 1 |
| Kruithof, S | 1 |
| Makuch, M | 1 |
| Culver, EL | 1 |
| van Bruggen, R | 1 |
| Remmerswaal, EBM | 1 |
| Ten Berge, IJM | 1 |
| Emmens, RW | 1 |
| Niessen, HWM | 1 |
| Barnes, E | 1 |
| Wolbink, GJ | 1 |
| van Ham, SM | 1 |
| Rispens, T | 1 |
| Liang, JX | 1 |
| Lin, J | 1 |
| Liu, J | 1 |
| Wang, X | 1 |
| Zhang, T | 1 |
| Li, J | 1 |
| Wu, Y | 2 |
| Venier, M | 1 |
| Salamova, A | 1 |
| Gonçales, VR | 1 |
| Lian, J | 1 |
| Gautam, S | 1 |
| Tilley, RD | 1 |
| Gooding, JJ | 1 |
| Kandel, YR | 1 |
| Bradley, CA | 1 |
| Chilvers, MI | 1 |
| Mathew, FM | 1 |
| Tenuta, AU | 1 |
| Smith, DL | 1 |
| Wise, KA | 1 |
| Mueller, DS | 1 |
| Lu, N | 1 |
| Lu, M | 1 |
| Liu, P | 1 |
| Xu, H | 1 |
| Qiu, X | 1 |
| Hu, S | 1 |
| Bai, S | 1 |
| Wu, J | 1 |
| Xue, S | 1 |
| Dai, X | 1 |
| Dharmage, SC | 1 |
| Abramson, MJ | 1 |
| Erbas, B | 1 |
| Bennett, CM | 1 |
| Svanes, C | 1 |
| Hui, J | 1 |
| Axelrad, C | 1 |
| Lowe, AJ | 1 |
| Lodge, CJ | 1 |
| Hoshi, M | 1 |
| Osawa, Y | 1 |
| Nakamoto, K | 1 |
| Morita, N | 1 |
| Yamamoto, Y | 1 |
| Ando, T | 1 |
| Tashita, C | 1 |
| Nabeshima, T | 1 |
| Saito, K | 1 |
| Gianesello, L | 1 |
| Del Prete, D | 1 |
| Ceol, M | 1 |
| Priante, G | 1 |
| Calò, LA | 1 |
| Anglani, F | 1 |
| Vekaria, HJ | 1 |
| Hubbard, WB | 1 |
| Scholpa, NE | 1 |
| Spry, ML | 1 |
| Gooch, JL | 1 |
| Prince, SJ | 1 |
| Schnellmann, RG | 1 |
| Sullivan, PG | 1 |
| Zhang, Q | 1 |
| Hu, R | 1 |
| Gu, Z | 1 |
| Zhang, M | 1 |
| Zhang, Z | 1 |
| Peng, Y | 1 |
| Feng, L | 1 |
| Li, X | 3 |
| Zhao, C | 1 |
| Sarfaraz, K | 1 |
| Gao, L | 1 |
| Wang, H | 1 |
| Wan, C | 1 |
| Leng, J | 1 |
| Yang, P | 1 |
| Gao, X | 1 |
| Gao, J | 1 |
| Emam, HE | 1 |
| Saad, NM | 1 |
| Abdallah, AEM | 1 |
| Ahmed, HB | 1 |
| Palombo, M | 1 |
| Ianus, A | 1 |
| Guerreri, M | 1 |
| Nunes, D | 1 |
| Alexander, DC | 1 |
| Shemesh, N | 1 |
| Zhang, H | 1 |
| Xiong, Q | 1 |
| Liu, YS | 1 |
| Hu, LX | 1 |
| Shi, ZQ | 1 |
| Ying, GG | 1 |
| Chen, R | 1 |
| Hong, X | 1 |
| Yan, S | 1 |
| Zha, J | 1 |
| Gu, H | 1 |
| Zhong, Q | 1 |
| Zeng, Y | 1 |
| Zhang, S | 1 |
| Bu, Y | 1 |
| Farghali, M | 1 |
| Mayumi, M | 1 |
| Syo, K | 1 |
| Satoshi, A | 1 |
| Seiichi, Y | 1 |
| Takashima, S | 1 |
| Ono, H | 1 |
| Ap, Y | 1 |
| Yamashiro, T | 1 |
| Ahmed, MM | 1 |
| Kotb, S | 1 |
| Iwasaki, M | 1 |
| Ihara, I | 1 |
| Umetsu, K | 1 |
| Hu, B | 1 |
| Wang, Y | 2 |
| Quan, J | 1 |
| Huang, K | 1 |
| Gu, X | 1 |
| Zhu, J | 1 |
| Yan, Y | 1 |
| Wu, P | 1 |
| Yang, L | 1 |
| Zhao, J | 1 |
| Koók, L | 1 |
| Nemestóthy, N | 1 |
| Bélafi-Bakó, K | 1 |
| Bakonyi, P | 1 |
| Luo, X | 1 |
| Zhang, F | 1 |
| Li, Q | 1 |
| Xia, Q | 1 |
| Li, Z | 1 |
| Ye, W | 1 |
| Li, S | 1 |
| Ge, C | 1 |
| Zakkula, A | 1 |
| Pulipati, S | 1 |
| Dittakavi, S | 1 |
| Bestha, RM | 1 |
| Zainuddin, M | 1 |
| Trivedi, RK | 1 |
| Mullangi, R | 1 |
| Lo, GH | 1 |
| Lin, CW | 1 |
| Tai, CM | 1 |
| Perng, DS | 1 |
| Chen, IL | 1 |
| Yeh, JH | 1 |
| Lin, HC | 1 |
| Rocha, GS | 1 |
| Silva, MKL | 1 |
| Cesarino, I | 1 |
| Hazzaa, SM | 1 |
| Abdelaziz, SAM | 1 |
| Abd Eldaim, MA | 1 |
| Abdel-Daim, MM | 1 |
| Elgarawany, GE | 1 |
| Larsson, P | 1 |
| Ljuslinder, I | 1 |
| Öhlund, D | 1 |
| Myte, R | 1 |
| Löfgren-Burström, A | 1 |
| Zingmark, C | 1 |
| Ling, A | 1 |
| Edin, S | 1 |
| Palmqvist, R | 1 |
| Murthi, P | 1 |
| Rajaraman, G | 1 |
| Erwich, JJHM | 1 |
| Dimitriadis, E | 1 |
| Yoon, HG | 1 |
| Oh, D | 1 |
| Ahn, YC | 1 |
| Noh, JM | 1 |
| Pyo, H | 1 |
| Cho, WK | 1 |
| Song, YM | 1 |
| Park, M | 1 |
| Hwang, NY | 1 |
| Sun, JM | 1 |
| Kim, HK | 1 |
| Zo, JI | 1 |
| Shim, YM | 1 |
| Persano, A | 1 |
| Quaranta, F | 1 |
| Taurino, A | 1 |
| Siciliano, PA | 1 |
| Iannacci, J | 1 |
| Malekbala, MR | 1 |
| Soltani, S | 1 |
| Abdul Rashid, S | 1 |
| Abdullah, LC | 1 |
| Rashid, U | 1 |
| Nehdi, IA | 1 |
| Choong, TSY | 1 |
| Teo, SH | 1 |
| Xu, P | 1 |
| Yan, F | 1 |
| Zhao, Y | 1 |
| Sun, S | 1 |
| Ying, L | 1 |
| Quinzi, V | 1 |
| Caruso, S | 1 |
| Mummolo, S | 1 |
| Nota, A | 1 |
| Angelone, AM | 1 |
| Mattei, A | 1 |
| Gatto, R | 1 |
| Marzo, G | 1 |
| Xin, W | 1 |
| Severino, J | 1 |
| Venkert, A | 1 |
| Yu, H | 1 |
| Knorr, D | 1 |
| Yang, JM | 1 |
| Carlson, L | 1 |
| Hicks, R | 1 |
| De Rosa, I | 1 |
| Beckmann, NA | 1 |
| Bitsch, RG | 1 |
| Schonhoff, M | 1 |
| Siebenrock, KA | 1 |
| Schwarze, M | 1 |
| Jaeger, S | 1 |
| Weinstein, RB | 2 |
| Ryan, PB | 1 |
| Berlin, JA | 2 |
| Schuemie, MJ | 1 |
| Swerdel, J | 2 |
| Fife, D | 2 |
| Ryan, P | 1 |
| Matcho, A | 1 |
| Schuemie, M | 1 |
| Patel, K | 1 |
| Cock, V | 1 |
| Edmonds, C | 1 |
| Cock, C | 1 |
| Fogleman, CD | 1 |
| Pellicano, R | 1 |
| Hernández Martínez, A | 1 |
| Lázaro Sáez, M | 1 |
| Bendezú García, RA | 1 |
| Patrón Román, GO | 1 |
| Roberts, E | 1 |
| Delgado Nunes, V | 1 |
| Buckner, S | 1 |
| Latchem, S | 1 |
| Constanti, M | 1 |
| Miller, P | 1 |
| Doherty, M | 1 |
| Zhang, W | 1 |
| Birrell, F | 1 |
| Porcheret, M | 1 |
| Dziedzic, K | 1 |
| Bernstein, I | 1 |
| Wise, E | 1 |
| Conaghan, PG | 1 |
| Wise, J | 1 |
| Mierzwa, G | 1 |
| Jakubczyk, M | 1 |
| Parzecka, M | 1 |
| Swincow, G | 1 |
| Popławski, C | 1 |
| Southey, ER | 1 |
| Soares-Weiser, K | 1 |
| Kleijnen, J | 1 |
| Loke, YK | 1 |
| Werner, MU | 2 |
| Nielsen, PR | 1 |
| Rømsing, J | 2 |
| García Rodríguez, LA | 2 |
| Hernández-Díaz, S | 2 |
| GOULSTON, K | 2 |
| FISHLER, JJ | 1 |
| SKYRING, A | 1 |
| JENNINGS, GH | 1 |
| Bannwarth, B | 1 |
| Neafsey, PJ | 1 |
| Blot, WJ | 2 |
| Fischer, T | 1 |
| Nielsen, GL | 2 |
| Friis, S | 1 |
| Mumma, M | 1 |
| Lipworth, L | 1 |
| DuBois, R | 1 |
| McLaughlin, JK | 2 |
| Sørensen, HT | 2 |
| Laman, CA | 1 |
| Silverstein, SB | 1 |
| Rodgers, GM | 1 |
| González-Pérez, A | 1 |
| Rodríguez, LA | 1 |
| Wilcox, CM | 1 |
| Rahme, E | 1 |
| Nedjar, H | 1 |
| Man, CY | 1 |
| Cheung, IT | 1 |
| Cameron, PA | 1 |
| Rainer, TH | 1 |
| Leeling, JL | 1 |
| Johnson, N | 1 |
| Helms, RJ | 1 |
| Gladtke, E | 1 |
| Ivey, KJ | 1 |
| Domschke, S | 1 |
| Domschke, W | 1 |
| Langman, MJ | 2 |
| Coggon, D | 1 |
| Spiegelhalter, D | 1 |
| Jick, H | 1 |
| Garnett, WR | 1 |
| Peterson, GM | 1 |
| Bergin, JK | 1 |
| Nelson, BJ | 1 |
| Stanton, LA | 1 |
| Jerussi, TP | 1 |
| Caubet, JF | 1 |
| McCray, JE | 1 |
| Handley, DA | 1 |
| Lesko, SM | 1 |
| Mitchell, AA | 1 |
| See, IO | 1 |
| Johnsen, SP | 1 |
| Mellemkjoer, L | 1 |
| Olsen, JH | 1 |
| MacLean, CH | 1 |
| Nielsen, OH | 1 |
| Madsen, JR | 1 |
| Schmidt, VM | 1 |
| Nielsen, HR | 1 |
| Le Parc, JM | 1 |
| Van Ganse, E | 1 |
| Moore, N | 1 |
| Wall, R | 1 |
| Schneid, H | 1 |
| Verrière, F | 1 |
| Hollister, LE | 1 |
| Tringham, VM | 1 |
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| Gazzard, BG | 1 |
| Portmann, B | 1 |
| Murray-Lyon, IM | 1 |
| Williams, R | 1 |
| Loebl, DH | 1 |
| Craig, RM | 1 |
| Culic, DD | 1 |
| Ridolfo, AS | 1 |
| Falk, J | 1 |
| Schmid, FR | 1 |
| Goodall, J | 1 |
| Day, R | 1 |
| Seideman, P | 1 |
| Langslow, A | 1 |
| Elliott, DP | 1 |
| Thornton, JR | 1 |
| Losowsky, MS | 1 |
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| Kaufman, DW | 1 |
| Siskind, V | 1 |
| Schwingl, P | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Channeling in the Use of Nonprescription Paracetamol and Ibuprofen in an Electronic Medical Records Database: Evidence and Implications[NCT02830178] | 144,337 participants (Actual) | Observational | 2016-01-31 | Completed | |||
| Does Acetaminophen Potentiate the Gastroduodenal Mucosal Injury of Aspirin? A Prospective, Randomized, Pilot Study.[NCT00594867] | Phase 4 | 94 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for acetaminophen and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Gastrointestinal damage by non-steroidal anti-inflammatory drugs: updated clinical considerations.
Topics: Acetaminophen; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cyclooxygenase 2 | 2014 |
Paracetamol: not as safe as we thought? A systematic literature review of observational studies.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Dose-Response Relationship, Drug; | 2016 |
Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Anaphylaxis; Child; Fever; Gastrointestinal Hem | 2009 |
Gastrointestinal safety of paracetamol: is there any cause for concern?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal D | 2004 |
Upper gastrointestinal complications among users of paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studi | 2006 |
Gastrointestinal Considerations in Patients with Cardiovascular Disease Using Nonopioid Analgesics for Mild-to-Moderate Pain or Cardioprotection.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cardiovascular Diseases; Cyclooxygenase 2 Inhibito | 2006 |
Use of antipyretic analgesics in the pediatric patient.
Topics: Acetaminophen; Adolescent; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemic | 1983 |
Gastrointestinal effects of antipyretic analgesics.
Topics: Acetaminophen; Adenosine Triphosphate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bicarbonate | 1983 |
Gastroduodenal damage due to drugs, alcohol and smoking.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Ethanol; Gastric Mucosa; Gastrointestinal | 1984 |
Effective use of analgesic drugs.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ast | 1976 |
Preventing upper gastrointestinal bleeding in patients receiving nonsteroidal antiinflammatory drugs.
Topics: Acetaminophen; Aged; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Contra | 1990 |
11 trials available for acetaminophen and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Effect of fetal lung maturation on the efficacy of acetaminophen for premature infants with patent ductus arteriosus.
Topics: Acetaminophen; Bronchopulmonary Dysplasia; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Enterocol | 2023 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Comparison of oral prednisolone/paracetamol and oral indomethacin/paracetamol combination therapy in the treatment of acute goutlike arthritis: a double-blind, randomized, controlled trial.
Topics: Abdominal Pain; Acetaminophen; Acute Disease; Administration, Oral; Aged; Aged, 80 and over; Analges | 2007 |
Improving drug use in rheumatic disorders.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Family Practice; G | 1996 |
Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Duodenal Dise | 1998 |
The safety of acetaminophen and ibuprofen among children younger than two years old.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Asthma; Bronchiolitis; Double-Blind Method; | 1999 |
Comparative tolerability of paracetamol, aspirin and ibuprofen for short-term analgesia in patients with musculoskeletal conditions: results in 4291 patients.
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Female; Ga | 2002 |
Aspirin, paracetamol, diflunisal, and gastrointestinal blood-loss.
Topics: Acetaminophen; Aspirin; Gastrointestinal Hemorrhage; Humans; Salicylates | 1979 |
Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers.
Topics: Acetaminophen; Aged; Arthritis, Rheumatoid; Aspirin; Autoradiography; Blood Specimen Collection; Fem | 1977 |
Effects of aspirin and an aspirin-acetaminophen combination on the gastric mucosa in normal subjects. A double-blind endoscopic study.
Topics: Acetaminophen; Adult; Aspirin; Double-Blind Method; Drug Administration Schedule; Drug Combinations; | 1985 |
Studies of gastrointestinal blood loss during ibuprofen therapy.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Benzyl Compounds; Calcium; Chromium Isotopes; Dige | 1970 |
45 other studies available for acetaminophen and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Ag | 2020 |
Channeling in the Use of Nonprescription Paracetamol and Ibuprofen in an Electronic Medical Records Database: Evidence and Implications.
Topics: Acetaminophen; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; | 2017 |
Complications related to chronic supratherapeutic use of codeine containing compound analgesics in a cohort of patients presenting for codeine withdrawal.
Topics: Acetaminophen; Acidosis, Renal Tubular; Adult; Analgesics; Anemia; Codeine; Drug Combinations; Femal | 2018 |
Analgesics for osteoarthritis.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Gastroi | 2013 |
[Chemical proctitis due to ergotamine: «not always an ulcerative colitis»].
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Diagnosis, Differ | 2015 |
True risks of paracetamol may be underestimated, say researchers.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cardiovascular Diseases; Dose-Response Relationship, Drug; | 2015 |
[Twenty-two months old girl with haemorrhagic gastritis as a complication after the nonsteroid anti-inflammatory drugs application--case report].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Female; Gastritis; Gastrointestinal Hemorrha | 2008 |
Aspirin or paracetamol - what's good for you?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical | 2009 |
Basic pain relievers. It's wise to use caution.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induc | 2012 |
Acetaminophen and upper gastrointestinal complications.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal H | 2002 |
GASTRO-INTESTINAL BLEEDING.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Chromium Isotopes; Gastr | 1964 |
EFFECTS OF ASPIRIN, ACETAMINOPHEN, AND SALICYLAMIDE ON GASTRIC MUCOSA OF DOGS.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Dogs; Gastric Mucosa; Ga | 1964 |
EFFECT OF PARACETAMOL (N-ACETYL-P-AMINOPHENOL) ON GASTROINTESTINAL BLEEDING.
Topics: Acetaminophen; Aspirin; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Occult Blood; Pharmacology; | 1964 |
PARACETAMOL OR ASPIRIN?
Topics: Acetaminophen; Aspirin; Gastrointestinal Hemorrhage; Hemorrhage; Toxicology | 1965 |
Double trouble: acetaminophen increases the risk of upper GI complications for people taking NSAIDs.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug | 2004 |
Outcome of upper gastro-intestinal bleeding and use of ibuprofen versus paracetamol.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2004 |
Parenteral iron therapy: a single institution's experience over a 5-year period.
Topics: Acetaminophen; Anemia, Iron-Deficiency; Diphenhydramine; Female; Ferric Compounds; Ferric Oxide, Sac | 2005 |
Risks and benefits of COX-2 inhibitors vs non-selective NSAIDs: does their cardiovascular risk exceed their gastrointestinal benefit? A retrospective cohort study.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 I | 2007 |
Effect of paracetamol coadministration on aspirin-induced gastrointestinal bleeding in dogs.
Topics: Acetaminophen; Animals; Aspirin; Dogs; Gastrointestinal Hemorrhage; Male | 1981 |
Analgesic intake and the risk of acute upper gastrointestinal bleeding.
Topics: Acetaminophen; Analgesics; Aspirin; Female; Gastrointestinal Hemorrhage; Hematemesis; Humans; Male; | 1983 |
Effects of aspirin and acetaminophen in gastrointestinal hemorrhage. Results from the Boston Collaborative Drug Surveillance Program.
Topics: Acetaminophen; Adult; Age Factors; Aged; Aspirin; Female; Gastrointestinal Hemorrhage; Hospitalizati | 1981 |
GI effects of OTC analgesics: implications for product selection.
Topics: Acetaminophen; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Dyspepsia; Gastrointestinal Hem | 1996 |
"Chap Kaki Tiga" a possible cause of upper gastrointestinal haemorrhage.
Topics: Acetaminophen; Analgesics; Aspirin; Caffeine; Drug Combinations; Gastrointestinal Hemorrhage; Humans | 1996 |
Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Case- | 2001 |
Hospitalisation for upper gastrointestinal bleeding associated with use of oral anticoagulants.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Inflamma | 2001 |
Quality indicators for the management of osteoarthritis in vulnerable elders.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Ste | 2001 |
[Paracetamol increases the risk of upper gastrointestinal hemorrhage and perforation].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Comb | 2001 |
[Does paracetamol increase the risk of gastric hemorrhage and perforation?].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Gastrointestinal Hemorrhage; Humans; Risk Factors | 2002 |
[Paracetamol increases the risk of upper gastrointestinal hemorrhage and perforation].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Gastrointestinal Hemorrhage; Humans; Risk Factors | 2002 |
Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Amanita; Autopsy; Brain Edema; Drug Hypersensit | 1975 |
Analgesics--the choice.
Topics: Acetaminophen; Aspirin; Gastrointestinal Hemorrhage; Humans; Pain | 1976 |
NSAIDs, musculoskeletal disorders and gastrointestinal adverse effects.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bone Diseases; Gastrointestinal Hemorr | 1991 |
Nurse and the law. Beware the vagaries of telephone orders.
Topics: Acetaminophen; Australia; Death; Dextropropoxyphene; Drug Combinations; Emergency Service, Hospital; | 1991 |
Fatal variceal haemorrhage after paracetamol overdose.
Topics: Acetaminophen; Adult; Drug Overdose; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hu | 1989 |
Major upper gastrointestinal tract bleeding. Relation to the use of aspirin and other nonnarcotic analgesics.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Aspirin; Drug Administration Schedule; Female; G | 1988 |
Smoking, nonsteroidal anti-inflammatory drugs, and acetaminophen in gastric ulcer. A study of associations and of the effects of previous diagnosis on exposure patterns.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Duodenal Ulc | 1988 |
Anti-inflammatory drug intake and the risk of ulcer complications.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastrointestinal Hemorrhage; | 1986 |
Gastrointestinal bleeding: a possible association with ibuprofen.
Topics: Acetaminophen; Aminopyrine; Analgesics; Anti-Inflammatory Agents; Aspirin; Benzyl Compounds; Child; | 1972 |
Pain in haemophilia.
Topics: Acetaminophen; Analgesics; Aspirin; Codeine; Cryotherapy; Gastrointestinal Hemorrhage; Headache; Hem | 1973 |
Bleeding gastritis induced by long-term release aspirin.
Topics: Acetaminophen; Adult; Aspirin; Delayed-Action Preparations; Drug Evaluation; Female; Gastric Mucosa; | 1974 |
Aspirin and gastric bleeding.
Topics: Acetaminophen; Aspirin; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer | 1967 |
Comparison of flufenamic acid with aspirin and paracetamol in terms of gastrointestinal blood loss.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chromium Isotopes; Fe | 1966 |
Aspirin gastritis examined with intragastric photography.
Topics: Acetaminophen; Adult; Antacids; Aspirin; Buffers; Drug Hypersensitivity; Drug Synergism; Female; Gas | 1969 |
Acute paracetamol poisoning.
Topics: Acetaminophen; Acidosis; Acute Disease; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and D | 1970 |
A safe aspirin preparation.
Topics: Acetaminophen; Aged; Arthritis; Aspirin; Female; Gastrointestinal Hemorrhage; Hemoglobinometry; Huma | 1970 |