acetaminophen has been researched along with Fissure in Ano in 2 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Fissure in Ano: A painful linear tear at the margin of the anus. It appears as a crack or slit in the mucous membrane of the anus and is very painful and difficult to heal.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application." | 9.17 | Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013) |
| " To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application." | 5.17 | Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013) |
| "Postoperative pain is a frequent cause for delayed discharge following outpatient procedures, including anorectal surgery." | 2.87 | Preemptive Analgesia Decreases Pain Following Anorectal Surgery: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial. ( Callas, P; Cataldo, PA; Dominick, T; Jordan, MR; Leahy, DT; Moore, JS; Van Backer, JT, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Backer, JT | 1 |
| Jordan, MR | 1 |
| Leahy, DT | 1 |
| Moore, JS | 1 |
| Callas, P | 1 |
| Dominick, T | 1 |
| Cataldo, PA | 1 |
| Berry, SM | 1 |
| Barish, CF | 1 |
| Bhandari, R | 1 |
| Clark, G | 1 |
| Collins, GV | 1 |
| Howell, J | 1 |
| Pappas, JE | 1 |
| Riff, DS | 1 |
| Safdi, M | 1 |
| Yellowlees, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single Institutional Randomized Controlled Trial for A Multimodal Enhanced Recovery Program in Anorectal Surgery[NCT03992079] | 60 participants (Actual) | Interventional | 2019-06-20 | Terminated (stopped due to PI is no longer at institution) | |||
| A Randomized. Double-blind, Placebo-controlled, Multi-national Study to Determine the Effect of Cellegesic Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With a Chronic Anal Fissure[NCT00522041] | Phase 3 | 248 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated and used to determine the change from Baseline. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A negative change score indicated improvement." (NCT00522041)
Timeframe: Baseline to Day 18
| Intervention | Units on a scale (Mean) |
|---|---|
| Cellegesic (Nitroglycerin 0.4%) | -40.4 |
| Placebo | -34.9 |
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A responder was defined as a participant with either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in the 24 hour average pain intensity averaged over Days 14 to 18." (NCT00522041)
Timeframe: Baseline to Day 18
| Intervention | Percentage of responders (Number) | |
|---|---|---|
| ≥ 50% decrease | ≥ 10 mm decrease | |
| Cellegisic (Nitroglycerin 0.4%) | 72.4 | 88.6 |
| Placebo | 64.5 | 85.5 |
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale (VAS) at Baseline and on each of the 21 treatment days of the study. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. Improvement was defined as either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in rated pain intensity." (NCT00522041)
Timeframe: Baseline to Day 21
| Intervention | Days (Mean) | |
|---|---|---|
| ≥ 50% decrease | ≥ 10 mm decrease | |
| Cellegisic (Nitroglycerin 0.4%) | 10.7 | 6.1 |
| Placebo | 13.2 | 7.2 |
2 trials available for acetaminophen and Fissure in Ano
| Article | Year |
|---|---|
Preemptive Analgesia Decreases Pain Following Anorectal Surgery: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial.
Topics: Acetaminophen; Adult; Ambulatory Surgical Procedures; Amines; Anal Canal; Analgesics; Analgesics, Op | 2018 |
Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Fissu | 2013 |