Page last updated: 2024-10-22

acetaminophen and Fever

acetaminophen has been researched along with Fever in 704 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Research Excerpts

ExcerptRelevanceReference
"Fever after removal of tube drainage is caused by a normal inflammatory response, and a small dose of acetaminophen could significantly reduce the possibility of fever."9.69A Randomized Study on the Prophylactic Use of Acetaminophen to Prevent Fever after the Removal of Drainage Tubes for Lumbar Surgery. ( Li, Y; Liu, K; Tian, Y; Xing, Y; Ye, K; Zhang, Y; Zhou, F, 2023)
"This study aims to evaluate the efficacy and safety of multiple or single-dosage intravenous ibuprofen (IVIB) in managing postoperative pain and fever in adults who are unable to take oral medications."9.41Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta-analysis of randomized controlled trials. ( Chen, L; He, L; Tian, S; Wang, E; Zhai, S; Zhou, P, 2023)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."9.41Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023)
"Intravenous acetaminophen did not demonstrate a higher efficacy than oral acetaminophen in treating intrapartum maternal fever."9.41Randomized control trial of intravenous acetaminophen for reduction of intrapartum maternal fever. ( Cabbad, M; Kanninen, T; Lakhi, N; Mehraban, S; Mehraban, SS; Moretti, M; Nematian, S; Parnas, Z; Petrucci, S; Shats, L; Tricorico, G, 2021)
"In adult age group patients admitted to the emergency department with high fever, the IV forms of 1000 mg paracetamol and 400 mg ibuprofen effectively and equally reduce complaints, such as fever and accompanying pain."9.41Comparison of intravenous ibuprofen and paracetamol in the treatment of fever: A randomized double-blind study. ( Can, Ö; Kıyan, GS; Yalçınlı, S, 2021)
"the overall result showed that ibuprofen had a better fever reducing effect compared to paracetamol."9.34Ibuprofen versus paracetamol for treating fever in preschool children in Nigeria: a randomized clinical trial of effectiveness and safety. ( Akande, PA; Alaje, EO; Meremikwu, MM; Odey, FA; Udoh, EE, 2020)
"This observational single-dose study was conducted at Department of Pedriatrics, Army Hospital (Research and Referral), a multispecialty tertiary care center in New Delhi in fever patients to assess the antipyretic efficacy of IV acetaminophen 15 mg/kg/dose vs."9.27Comparison of Antipyretic Efficacy of Intravenous (IV) Acetaminophen versus Oral (PO) Acetaminophen in the Management of Fever in Children. ( Roy, S; Simalti, AK, 2018)
"No evidence can be found in the medical literature about the efficacy of alternating acetaminophen and ibuprofen treatment in children with refractory fever."9.24Alternating Acetaminophen and Ibuprofen versus Monotherapies in Improvements of Distress and Reducing Refractory Fever in Febrile Children: A Randomized Controlled Trial. ( Guo, Q; Luo, Q; Luo, S; Ran, M; Shu, M; Wan, C; Xie, X; Zhang, C; Zhu, Y, 2017)
"001); in a greater reduction in change from baseline temperature compared to treatment with acetaminophen, and it reduced fever throughout a 24 h dosing period."9.24A multicenter, randomized, open-label, active-comparator trial to determine the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for treatment of fever in hospitalized pediatric patients. ( Chumpitazi, CE; Hahn, BJ; Kaelin, BA; Khalil, SN; Macias, CG; Rock, AD, 2017)
"PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) was a multicenter, randomized, double-blind, placebo-controlled clinical trial."9.24PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial. ( Algra, A; de Ridder, IR; den Hertog, HM; Dippel, DW; Jansen, BP; Kappelle, LJ; Koudstaal, PJ; Maasland, EL; Ruitenberg, A; Saxena, R; Schreuder, AH; Van den Berg-Vos, RM; van der Worp, HB; van Gemert, HM; van Tuijl, JH; Vermeij, F, 2017)
"To evaluate ibuprofen and acetaminophen in the treatment of infectious fever in children."9.22Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis. ( Guo, H; Liu, Y; Yin, F, 2022)
"Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking."9.22Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016)
"The Paracetamol (Acetaminophen) In Stroke 2 trial is a multicenter, randomized, double-blind, placebo-controlled clinical trial."9.20Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 ° ( Algra, A; de Jong, FJ; de Ridder, IR; den Hertog, HM; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Lingsma, HF; Maasland, EL; Oomes, P; Ruitenberg, A; Saxena, R; Schreuder, AH; van der Worp, HB; van Gemert, HM; van Tuijl, J, 2015)
"Acetaminophen is a common therapy for fever in patients in the intensive care unit (ICU) who have probable infection, but its effects are unknown."9.20Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. ( Beasley, R; Bellomo, R; Freebairn, R; Hammond, N; Henderson, S; Holliday, M; Mackle, D; McArthur, C; McGuinness, S; Myburgh, J; Saxena, M; van Haren, F; Weatherall, M; Webb, S; Young, P, 2015)
"The combination of dabrafenib and trametinib (CombiDT) is an effective treatment for BRAF-mutant metastatic melanoma; however, over 70% of patients develop drug-related pyrexia, and little is known about this toxicity."9.19Features and management of pyrexia with combined dabrafenib and trametinib in metastatic melanoma. ( Azer, M; Clements, A; Haydu, LE; Kefford, RF; Lee, CI; Long, GV; Menzies, AM, 2014)
"The purpose of this study was to assess the safety and dynamics of the onset of antipyretic efficacy of intravenous (IV) acetaminophen versus oral (PO) acetaminophen in the treatment of endotoxin-induced fever."9.15A randomized study of the efficacy and safety of intravenous acetaminophen compared to oral acetaminophen for the treatment of fever. ( Breitmeyer, JB; Pan, C; Peacock, WF; Royal, MA; Smith, WB, 2011)
") acetaminophen using an endotoxin-induced fever model."9.15A randomized study of the efficacy and safety of intravenous acetaminophen vs. intravenous placebo for the treatment of fever. ( Ang, R; Breitmeyer, JB; Kett, DH; Royal, MA, 2011)
"The results of this relatively small trial suggest that acetaminophen may reduce the risk of post-vaccination fever and fussiness."9.15A randomized placebo-controlled trial of acetaminophen for prevention of post-vaccination fever in infants. ( Benoit, J; Benson, P; Carste, B; Dominguez-Islas, CP; Dunn, J; Dunstan, M; Hambidge, SJ; Jackson, LA; Nelson, JC; Peterson, D; Starkovich, P; Yu, O, 2011)
"Routine prophylactic acetaminophen after DPT vaccination was effective in reducing the frequency of fever and irritability in the initial 6 hours."9.15Immediate versus as-needed acetaminophen for post-immunisation pyrexia. ( Dhingra, B; Mishra, D, 2011)
"To establish the relative clinical effectiveness and cost-effectiveness of paracetamol plus ibuprofen compared with paracetamol and ibuprofen separately for time without fever, and the relief of fever-associated discomfort in young children who can be managed at home."9.14Paracetamol and ibuprofen for the treatment of fever in children: the PITCH randomised controlled trial. ( Costelloe, C; Fletcher, M; Hay, AD; Hollinghurst, S; Montgomery, AA; Peters, TJ; Redmond, NM, 2009)
"To compare three dose levels of ketoprofen with paracetamol (acetaminophen) in the management of fever in children."9.14Dose-finding studies of ketoprofen in the management of fever in children: report on two randomized, single-blind, comparator-controlled, single-dose, multicentre, phase II studies. ( Kokki, H; Kokki, M, 2010)
"Acetaminophen and diphenhydramine are commonly used as pretransfusion medications to prevent transfusion reactions."9.13A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. ( Case, LD; Cruz, JM; Hurd, DD; Kennedy, LD; Pomper, GJ, 2008)
"To investigate whether paracetamol (acetaminophen) plus ibuprofen are superior to either drug alone for increasing time without fever and the relief of fever associated discomfort in febrile children managed at home."9.13Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. ( Costelloe, C; Fletcher, M; Hay, AD; Hollinghurst, S; Montgomery, AA; Peters, TJ; Redmond, NM, 2008)
"The Paracetamol (Acetaminophen) In Stroke (PAIS) study is a phase III multicenter, double blind, randomized, placebo-controlled clinical trial of high-dose acetaminophen in patients with acute stroke."9.13Correction: PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN74418480]. ( Algra, A; den Hertog, HM; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van der Worp, HB; van Gemert, HM; van Gijn, J, 2008)
"According to this study: In children younger than age two, treatment with ibuprofen was associated with reduced fever and less pain within the first 24 hours compared with acetaminophen."9.12Ibuprofen Better than Acetaminophen for Reducing Fever, Pain in Young Children. ( Rosenberg, K, 2021)
"5 mg/kg per dose) and ibuprofen (5 mg/kg per dose) every 4 hours for 3 days, regardless of the initial loading medication, is more effective than monotherapy in lowering fever in infants and children."9.12Antipyretic treatment in young children with fever: acetaminophen, ibuprofen, or both alternating in a randomized, double-blind study. ( Cohen, HA; Sarrell, EM; Wielunsky, E, 2006)
"A randomised open label study of the combined use of paracetamol and ibuprofen to rapidly reduce fever is reported."9.12Randomised controlled trial of combined paracetamol and ibuprofen for fever. ( Benger, JR; Chinnick, PJ; Coppens, K; Davies, P; Erlewyn-Lajeunesse, MD; Higginson, IM; Hunt, LP, 2006)
"An intravenous formulation of paracetamol and an intravenous formulation of propacetamol (prodrug of paracetamol) were compared in children with acute fever due to infection in order to determine the antipyretic efficacy and safety during the 6-hour period after administration."9.12Antipyretic efficacy and safety of a single intravenous administration of 15 mg/kg paracetamol versus 30 mg/kg propacetamol in children with acute fever due to infection. ( Dalphin, ML; Duhamel, JF; Le Gall, E; Payen-Champenois, C, 2007)
"Children from the age of 3 months to 12 years with a fever of non-serious origin were randomized to receive either ibuprofen or paracetamol."9.12Ibuprofen versus paracetamol in pediatric fever: objective and subjective findings from a randomized, blinded study. ( Autret-Leca, E; Gibb, IA; Goulder, MA, 2007)
"In the majority of patients with acute ischemic stroke, ASA and acetaminophen are insufficient for reducing an elevated BT to a state of normothermia."9.11Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke. ( De Keyser, J; Elting, JW; Luijckx, GJ; Luyckx, GJ; Maurits, N; Sulter, G, 2004)
"Acetaminophen prophylaxis prevented neither maternal hyperthermia nor fever secondary to epidural analgesia, suggesting that the mechanism underlying fever does not include centrally mediated perturbations of maternal thermoregulation."9.11Prophylactic acetaminophen does not prevent epidural fever in nulliparous women: a double-blind placebo-controlled trial. ( Citron, DR; Evans, T; Goetzl, L; Lieberman, E; Richardson, BE; Rivers, J; Suresh, MS, 2004)
"Aspirin (acetylsalicylic acid) and acetaminophen (paracetamol) are frequently used to treat fever and other symptoms of upper respiratory tract infection (URTI)."9.11Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging st ( Bachert, C; Chuchalin, AG; Eisebitt, R; Netayzhenko, VZ; Voelker, M, 2005)
" In a previous randomized trial we observed that treatment with high-dose acetaminophen (paracetamol) led to a reduction of body temperature in patients with acute ischemic stroke, even when they had no fever."9.10Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003)
"Early administration of acetaminophen (3900 mg/d) to afebrile patients with acute stroke may result in a small reduction in CBT."9.10Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial. ( Chalela, JA; Grotta, JC; Kasner, SE; Kimmel, SE; Krieger, DW; Morgenstern, LB; Piriyawat, P; Villar-Cordova, CE; Wein, T, 2002)
"Rather than supporting the hypothesis that ibuprofen increases asthma morbidity among children who are not known to be sensitive to aspirin or other nonsteroidal antiinflammatory drugs, these data suggest that compared with acetaminophen, ibuprofen may reduce such risks."9.10Asthma morbidity after the short-term use of ibuprofen in children. ( Lesko, SM; Louik, C; Mitchell, AA; Vezina, RM, 2002)
"Acetaminophen was the superior antipyretic drug in endotoxemia compared with aspirin."9.09Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial. ( Bieglmayer, C; Eichler, HG; Jilma, B; Kapiotis, S; Pernerstorfer, T; Schmid, R, 1999)
"The purpose of this preliminary study was to compare acetaminophen to ketorolac for treating patients with fever in the emergency department (ED)."9.09Ketorolac versus acetaminophen for treatment of acute fever in the emergency department. ( Ernst, A; Houry, D; Ledbetter, M; Weiss, S, 1999)
"The aim of this study was to assess and compare the efficacy and tolerability of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections (URTIs)."9.09Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections. ( Cin, S; Köksal, Y; Ulukol, B, 1999)
"The objectives of this prospective non-concurrent cohort study were to confirm the efficacy of vaginal misoprostol for early pregnancy termination and to determine whether the incidence of side effects is lower with prophylactic loperamide and acetaminophen."9.09Early pregnancy termination with vaginal misoprostol combined with loperamide and acetaminophen prophylaxis. ( Harwood, B; Jain, JK; Meckstroth, KR; Mishell, DR, 2001)
"Seventy-five patients with acute ischemic stroke confined to the anterior circulation were randomized to treatment with either 500 mg (low dose) or 1000 mg (high dose) acetaminophen or with placebo, administered as suppositories 6 times daily during 5 days."9.09Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2001)
"5 mg/kg per dose), aspirin (10 mg/kg/dose) and paracetamol (10 mg/kg per dose) on children with fever aged 6-24 months in an open, randomised study with three parallel groups."9.08Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever. ( Autret, E; Courcier, S; Goehrs, JM; Henry-Launois, B; Laborde, C; Languillat, G; Launois, R; Reboul-Marty, J, 1997)
"The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever."9.07A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children. ( Comito, A; Pieragostini, P; Polidori, G; Scaricabarozzi, I; Titti, G, 1993)
"The authors studied the antipyretic effect of three intramuscular doses of ketorolac (15, 30, and 60 mg), acetaminophen 650 mg PO, and placebo in healthy male volunteers using an endotoxin-induced fever model."9.07Evaluation of the antipyretic effect of ketorolac, acetaminophen, and placebo in endotoxin-induced fever. ( Bynum, L; Maneatis, T; McMahon, FG; Peterson, C; Vargas, R, 1994)
"kg-1 acetaminophen syrup (n = 77) in 154 children (6 months to 5 years) with fever (> or = 38 degrees C) associated with infectious diseases and treated with antibiotic therapy."9.07Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics. ( Autret, E; Breart, G; Courcier, S; Goehrs, JM; Jonville, AP; Lassale, C, 1994)
"The effect of acetaminophen on fever in bacterial vs."9.06Fever response to acetaminophen in viral vs. bacterial infections. ( Brien, JH; Miller, G; Weisse, ME, 1987)
"Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children."9.05Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis. ( Braithwaite, I; Dalziel, SR; McKinlay, CJD; Tan, E, 2020)
"The present randomized single-blind trial was performed to study antipyretic effect and tolerability of alpha-methyl-4-(2-thienylcarbonyl)-phenyl acetic acid (suprofen, Suprol) suppositories versus paracetamol (acetaminophen) suppositories in pediatric patients with fever of various etiology."9.05Clinical experience and results of treatment with suprofen in pediatrics. 2nd communication: Use of suprofen suppositories as an antipyretic in children with fever due to acute infections/A single-blind controlled study of suprofen versus paracetamol. ( Michos, N; Stocker, H; Sundal, EJ; Weippl, G, 1985)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."8.93Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016)
"Combination treatment with ibuprofen and acetaminophen is beneficial over either agent alone for sustained fever reduction in children older than 6 months."8.89Does combination treatment with ibuprofen and acetaminophen improve fever control? ( Malya, RR, 2013)
"To analyse major sources of evidence-based information on the efficacy and gastrointestinal tolerability of aspirin, used short-term, in over-the-counter (OTC) doses, to relieve acute pain and cold symptoms, including associated feverishness."8.88Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold. ( McCarthy, DM, 2012)
"Acetylsalicylic acid (ASA [aspirin]) is a commonly used over-the-counter drug for the treatment of pain, fever, or colds, but data on the safety of this use are very limited."8.87Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials. ( Baron, JA; Brueckner, A; Lanas, A; McCarthy, D; Senn, S; Voelker, M, 2011)
"Paracetamol and ibuprofen are safe and effective medications for reducing a fever in children and young people and they are often administered together with a view to reducing a temperature quickly."8.86Fever management: evaluating the use of ibuprofen and paracetamol. ( Crook, J, 2010)
"Schultz et al (2008) raised the question whether regression into autism is triggered, not by the measles-mumps-rubella (MMR) vaccine, but by acetaminophen (Tylenol) given for its fever and pain."8.85Did acetaminophen provoke the autism epidemic? ( Good, P, 2009)
"To characterize clozapine-induced fever and suggest clinically relevant management recommendations."8.84Characterization and clinical management of clozapine-induced fever. ( Grube, RR; Lowe, CM; Scates, AC, 2007)
"Although many studies have investigated the safety and tolerability of ibuprofen or acetaminophen (paracetamol) use in children, few have specifically examined the association of ibuprofen or acetaminophen and the occurrence of asthma in pediatric populations."8.84A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. ( Dale, S; Kanabar, D; Rawat, M, 2007)
"To summarize studies testing the efficacy and safety of single-dose acetaminophen and ibuprofen for treating children's pain or fever."8.82Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis. ( Champion, GD; Goodenough, B; Perrott, DA; Piira, T, 2004)
"This study was undertaken to evaluate the efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen in comparison with as-needed acetaminophen alone for prevention of seizure recurrence during the same fever episode in suspected pediatric simple febrile seizures (SFS)."8.12Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures. ( Fujita, S; Hataya, H; Kishibe, S; Miyama, S; Morikawa, EK; Morikawa, Y; Narita, K; Sammori, H; Suzuki, S; Takehira, K; Tanaka, M; Tsukamoto, J; Wang, Q; Yano, M, 2022)
"The pharmacological specificities of the rectal formulation of acetaminophen led to a debate on its appropriateness for managing fever in children, but few data are available on the formulation's current use and determinants of use."7.83Enduring large use of acetaminophen suppositories for fever management in children: a national survey of French parents and healthcare professionals' practices. ( Bertille, N; Chalumeau, M; Fournier-Charrière, E; Khoshnood, B; Pons, G, 2016)
"Acetaminophen is a commonly used medication to manage fever and pain in children and the drug is generally considered to be safe when used at appropriate therapeutic dosages."7.81Severe intrinsic acute kidney injury associated with therapeutic doses of acetaminophen. ( Aizawa, T; Hirono, K; Ito, E; Ito, T; Joh, K; Tanaka, H; Tsuruga, K; Watanabe, S, 2015)
"Acetaminophen is one of the world's most commonly used drugs to treat fever and pain, yet its mechanism of action has remained unclear."7.79Acetaminophen reduces lipopolysaccharide-induced fever by inhibiting cyclooxygenase-2. ( Blomqvist, A; Elander, L; Engblom, D; Engström Ruud, L; Eskilsson, A; Vasilache, AM; Wilhelms, DB, 2013)
"Children who have unresolved pain despite the use of either ibuprofen or acetaminophen should have their medication regimen reviewed to ensure they are receiving the medication at an adequate dose and interval."7.78Alternating acetaminophen and ibuprofen for pain in children. ( Goldman, RD; Smith, C, 2012)
"Acetaminophen use in children has been associated with increased autism risk."7.76Can autism be triggered by acetaminophen activation of the endocannabinoid system? ( Schultz, ST, 2010)
"Paracetamol (Acetaminophen) In Stroke (PAIS) is a randomized, double-blind clinical trial, comparing high-dose acetaminophen with placebo in 2500 patients."7.73PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial [ISCRTN 74418480]. ( Algra, A; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van Breda, EJ; van der Worp, HB; van Gemert, HM; van Gijn, J, 2005)
"Children frequently suffer infections accompanied by fever, which is commonly treated with acetaminophen (paracetamol), a use not devoid of risk."7.73The effects of a complex homeopathic medicine compared with acetaminophen in the symptomatic treatment of acute febrile infections in children: an observational study. ( Derasse, M; Klein, P; Weiser, M, 2005)
"The present study was designed to determine whether the inhibition of glutamate release in organum vasculosum laminae terminalis (OVLT) of rabbit brain by acetaminophen might be protective in a whole-animal model of staphylococcal enterotoxin A (SEA) fever."7.72Antipyretic effect of acetaminophen by inhibition of glutamate release after staphylococcal enterotoxin A fever in rabbits. ( Huang, WT; Lin, MT; Wang, JJ, 2004)
"Seventy-five (3 x 25) patients with acute ischaemic stroke confined to the anterior circulation will be randomised to treatment with either: 400 mg ibuprofen, 1000 mg acetaminophen, or with placebo 6 times daily during 5 days."7.71PISA. The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: protocol for a phase II double-blind randomised placebo-controlled trial [ISRCTN98608690]. ( Dippel, DW; Kappelle, J; Koudstaal, PJ; Meijer, R; van Breda, EJ; van der Worp, B; van Gemert, M, 2002)
"A cohort of 484 febrile children were examined to (1) assess the utility of temperature response to acetaminophen as a diagnostic test for occult bacteremia (OB) and (2) compare it with the white blood cell (WBC) count."7.69Diagnostic tests for occult bacteremia: temperature response to acetaminophen versus WBC count. ( Kozinetz, CA; Mazur, LJ, 1994)
"We have investigated the effect of malaria infection with the rodent parasite Plasmodium berghei and fever induced by Escherichia coli endotoxin on the metabolism of phenacetin to paracetamol by rat liver microsomes from young (4 weeks old) male Wistar rats (N = 5 in control and fever groups; N = 10 in malaria-infected group)."7.68Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes. ( Breckenridge, AM; Edwards, G; Glazier, AP; Kokwaro, GO; Ward, SA, 1993)
"Fever is a common symptom in children and one of the major concerns of parents of younger and preschool-age children."6.75Ketoprofen versus paracetamol (acetaminophen) or ibuprofen in the management of fever: results of two randomized, double-blind, double-dummy, parallel-group, repeated-dose, multicentre, phase III studies in children. ( Kokki, H; Kokki, M, 2010)
"At physician-directed dosing (acetaminophen 15 mg/kg vs ibuprofen 10 mg/kg), no significant differences in antipyretic effects from 0‒6 h and between 0‒6, ‒12, ‒24, or ‒48 h, with single or multiple-doses, respectively, were observed."6.72Acetaminophen and ibuprofen in the treatment of pediatric fever: a narrative review. ( Paul, IM; Walson, PD, 2021)
"Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects."6.45Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009)
" In summary, all methodologically sound studies available indicate that therapeutic dosing of paracetamol to the alcoholic patient is not associated with hepatic injury."6.41Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. ( Dart, RC; Kuffner, EK; Rumack, BH, 2000)
"Fever after removal of tube drainage is caused by a normal inflammatory response, and a small dose of acetaminophen could significantly reduce the possibility of fever."5.69A Randomized Study on the Prophylactic Use of Acetaminophen to Prevent Fever after the Removal of Drainage Tubes for Lumbar Surgery. ( Li, Y; Liu, K; Tian, Y; Xing, Y; Ye, K; Zhang, Y; Zhou, F, 2023)
"Fever has been reported as a common symptom occurring in COVID-19 illness."5.56The use of ibuprofen to treat fever in COVID-19: A possible indirect association with worse outcome? ( Haryadi, TH; Jamerson, BD, 2020)
" The Paracetamol and Ibuprofen in the Primary Prevention of Asthma in Tamariki (PIPPA Tamariki) trial is an open-label, randomised controlled trial aiming to determine whether paracetamol treatment, compared with ibuprofen treatment, as required for fever and pain in the first year of life, increases the risk of asthma at age six years."5.51Panic or peace - prioritising infant welfare when medicating feverish infants: a grounded theory study of adherence in a paediatric clinical trial. ( Braithwaite, I; Dalziel, SR; Fernando, K; Haskell, L; Hoare, K; McKinlay, CJ; Riley, J; Tan, E, 2022)
" Eligible children will receive treatment allocation randomization either to standard of care for fever management or to prophylactic, scheduled treatment every 6 hours for 72 hours with dual antipyretic therapies using acetaminophen and ibuprofen."5.51Aggressive antipyretics in central nervous system malaria: Study protocol of a randomized-controlled trial assessing antipyretic efficacy and parasite clearance effects (Malaria FEVER study). ( Birbeck, GL; Chilombe, MB; Mathews, M; McDermott, MP; Mwenechanya, M; Seydel, KB, 2022)
" Intravenous acetaminophen, with its increased bioavailability and more rapid onset of action, may have benefit in the intrapartum setting by reducing adverse neonatal and maternal outcomes associated with febrile morbidity."5.46Intravenous acetaminophen for the treatment of intrapartum fever and resolution of fetal tachycardia: a novel use for an old medication. ( Burgess, APH; Lakhi, N; Moretti, M; Ope-Adenuga, S; Reilly, JG, 2017)
"This study aims to evaluate the efficacy and safety of multiple or single-dosage intravenous ibuprofen (IVIB) in managing postoperative pain and fever in adults who are unable to take oral medications."5.41Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta-analysis of randomized controlled trials. ( Chen, L; He, L; Tian, S; Wang, E; Zhai, S; Zhou, P, 2023)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."5.41Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023)
"Intravenous acetaminophen did not demonstrate a higher efficacy than oral acetaminophen in treating intrapartum maternal fever."5.41Randomized control trial of intravenous acetaminophen for reduction of intrapartum maternal fever. ( Cabbad, M; Kanninen, T; Lakhi, N; Mehraban, S; Mehraban, SS; Moretti, M; Nematian, S; Parnas, Z; Petrucci, S; Shats, L; Tricorico, G, 2021)
"In adult age group patients admitted to the emergency department with high fever, the IV forms of 1000 mg paracetamol and 400 mg ibuprofen effectively and equally reduce complaints, such as fever and accompanying pain."5.41Comparison of intravenous ibuprofen and paracetamol in the treatment of fever: A randomized double-blind study. ( Can, Ö; Kıyan, GS; Yalçınlı, S, 2021)
"(1) Renal colic is an acute syndrome involving unilateral flank pain, linked to an obstruction in the upper urinary tract."5.35Renal colic in adults: NSAIDs and morphine are effective for pain relief. ( , 2009)
"the overall result showed that ibuprofen had a better fever reducing effect compared to paracetamol."5.34Ibuprofen versus paracetamol for treating fever in preschool children in Nigeria: a randomized clinical trial of effectiveness and safety. ( Akande, PA; Alaje, EO; Meremikwu, MM; Odey, FA; Udoh, EE, 2020)
"He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated."5.34Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007)
"This observational single-dose study was conducted at Department of Pedriatrics, Army Hospital (Research and Referral), a multispecialty tertiary care center in New Delhi in fever patients to assess the antipyretic efficacy of IV acetaminophen 15 mg/kg/dose vs."5.27Comparison of Antipyretic Efficacy of Intravenous (IV) Acetaminophen versus Oral (PO) Acetaminophen in the Management of Fever in Children. ( Roy, S; Simalti, AK, 2018)
"We aimed to compare the antipyretic efficacy, safety, and tolerability between oral dexibuprofen and intravenous propacetamol in children with upper respiratory tract infection (URTI) presenting with fever."5.27The antipyretic efficacy and safety of propacetamol compared with dexibuprofen in febrile children: a multicenter, randomized, double-blind, comparative, phase 3 clinical trial. ( Choi, SJ; Choi, UY; Chun, YH; Jeong, DC; Kim, HM; Lee, J; Lee, JH; Moon, S; Rhim, JW, 2018)
"Acetaminophen (15 mg/kg) was administered to each child and repeat temperatures were taken one and two hours later."5.27Childhood fever: correlation of diagnosis with temperature response to acetaminophen. ( Baker, MD; Carpenter, RO; Fosarelli, PD, 1987)
"No evidence can be found in the medical literature about the efficacy of alternating acetaminophen and ibuprofen treatment in children with refractory fever."5.24Alternating Acetaminophen and Ibuprofen versus Monotherapies in Improvements of Distress and Reducing Refractory Fever in Febrile Children: A Randomized Controlled Trial. ( Guo, Q; Luo, Q; Luo, S; Ran, M; Shu, M; Wan, C; Xie, X; Zhang, C; Zhu, Y, 2017)
"No randomized study has been conducted to investigate the use of intravenous paracetamol (acetaminophen, APAP) for the management of fever due to infection."5.24Randomized, controlled, multicentre clinical trial of the antipyretic effect of intravenous paracetamol in patients admitted to hospital with infection. ( Akinosoglou, K; Giamarellos-Bourboulis, EJ; Gogos, C; Karagiannis, A; Koupetori, M; Pyrpasopoulou, A; Soumelas, GS; Sympardi, S; Tsaganos, T; Tseti, IK; Tsokos, N; Tziolos, N, 2017)
"Two blinded single-dose studies randomized children 6 months to 11 years old with fever to receive ibuprofen (IBU) pediatric suspension 7."5.24Antipyretic Efficacy and Safety of Ibuprofen Versus Acetaminophen Suspension in Febrile Children: Results of 2 Randomized, Double-Blind, Single-Dose Studies. ( Jayawardena, S; Kellstein, D, 2017)
"001); in a greater reduction in change from baseline temperature compared to treatment with acetaminophen, and it reduced fever throughout a 24 h dosing period."5.24A multicenter, randomized, open-label, active-comparator trial to determine the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for treatment of fever in hospitalized pediatric patients. ( Chumpitazi, CE; Hahn, BJ; Kaelin, BA; Khalil, SN; Macias, CG; Rock, AD, 2017)
"PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) was a multicenter, randomized, double-blind, placebo-controlled clinical trial."5.24PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial. ( Algra, A; de Ridder, IR; den Hertog, HM; Dippel, DW; Jansen, BP; Kappelle, LJ; Koudstaal, PJ; Maasland, EL; Ruitenberg, A; Saxena, R; Schreuder, AH; Van den Berg-Vos, RM; van der Worp, HB; van Gemert, HM; van Tuijl, JH; Vermeij, F, 2017)
"To evaluate ibuprofen and acetaminophen in the treatment of infectious fever in children."5.22Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis. ( Guo, H; Liu, Y; Yin, F, 2022)
"In May and June 2020, an open-date literature search of English publications indexed in ProQuest, PubMed, and EBSCO was conducted with the search terms 'acetaminophen' and 'hypotension' and related search combinations ('paracetamol', 'propacetamol', 'low blood pressure', 'fever', 'sepsis', and 'shock') to identify peer-reviewed publications of blood pressure changes after paracetamol administration in humans."5.22A narrative review of paracetamol-induced hypotension: Keeping the patient safe. ( Young, TL, 2022)
"Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking."5.22Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016)
"The Paracetamol (Acetaminophen) In Stroke 2 trial is a multicenter, randomized, double-blind, placebo-controlled clinical trial."5.20Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 ° ( Algra, A; de Jong, FJ; de Ridder, IR; den Hertog, HM; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Lingsma, HF; Maasland, EL; Oomes, P; Ruitenberg, A; Saxena, R; Schreuder, AH; van der Worp, HB; van Gemert, HM; van Tuijl, J, 2015)
"Acetaminophen is a common therapy for fever in patients in the intensive care unit (ICU) who have probable infection, but its effects are unknown."5.20Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. ( Beasley, R; Bellomo, R; Freebairn, R; Hammond, N; Henderson, S; Holliday, M; Mackle, D; McArthur, C; McGuinness, S; Myburgh, J; Saxena, M; van Haren, F; Weatherall, M; Webb, S; Young, P, 2015)
"The combination of dabrafenib and trametinib (CombiDT) is an effective treatment for BRAF-mutant metastatic melanoma; however, over 70% of patients develop drug-related pyrexia, and little is known about this toxicity."5.19Features and management of pyrexia with combined dabrafenib and trametinib in metastatic melanoma. ( Azer, M; Clements, A; Haydu, LE; Kefford, RF; Lee, CI; Long, GV; Menzies, AM, 2014)
"316 patients (6 months-12 years) with fever were randomly assigned to receive a single dose of acetaminophen or ketoprofen orally."5.16Comparison of acetaminophen and ketoprofen in febrile children: a single dose randomized clinical trial. ( Erkek, N; Karacan, CD; Senel, S, 2012)
"The purpose of this study was to assess the safety and dynamics of the onset of antipyretic efficacy of intravenous (IV) acetaminophen versus oral (PO) acetaminophen in the treatment of endotoxin-induced fever."5.15A randomized study of the efficacy and safety of intravenous acetaminophen compared to oral acetaminophen for the treatment of fever. ( Breitmeyer, JB; Pan, C; Peacock, WF; Royal, MA; Smith, WB, 2011)
") acetaminophen using an endotoxin-induced fever model."5.15A randomized study of the efficacy and safety of intravenous acetaminophen vs. intravenous placebo for the treatment of fever. ( Ang, R; Breitmeyer, JB; Kett, DH; Royal, MA, 2011)
"The results of this relatively small trial suggest that acetaminophen may reduce the risk of post-vaccination fever and fussiness."5.15A randomized placebo-controlled trial of acetaminophen for prevention of post-vaccination fever in infants. ( Benoit, J; Benson, P; Carste, B; Dominguez-Islas, CP; Dunn, J; Dunstan, M; Hambidge, SJ; Jackson, LA; Nelson, JC; Peterson, D; Starkovich, P; Yu, O, 2011)
"Routine prophylactic acetaminophen after DPT vaccination was effective in reducing the frequency of fever and irritability in the initial 6 hours."5.15Immediate versus as-needed acetaminophen for post-immunisation pyrexia. ( Dhingra, B; Mishra, D, 2011)
"To establish the relative clinical effectiveness and cost-effectiveness of paracetamol plus ibuprofen compared with paracetamol and ibuprofen separately for time without fever, and the relief of fever-associated discomfort in young children who can be managed at home."5.14Paracetamol and ibuprofen for the treatment of fever in children: the PITCH randomised controlled trial. ( Costelloe, C; Fletcher, M; Hay, AD; Hollinghurst, S; Montgomery, AA; Peters, TJ; Redmond, NM, 2009)
"To compare three dose levels of ketoprofen with paracetamol (acetaminophen) in the management of fever in children."5.14Dose-finding studies of ketoprofen in the management of fever in children: report on two randomized, single-blind, comparator-controlled, single-dose, multicentre, phase II studies. ( Kokki, H; Kokki, M, 2010)
"Subjects were randomized (3:3:1) to receive IV acetaminophen (1,000mg q6h or 650mg q4h) or standard-of-care treatment for pain or fever."5.14Safety of multiple-dose intravenous acetaminophen in adult inpatients. ( Bergese, SD; Candiotti, KA; Royal, MA; Singla, NK; Singla, SK; Viscusi, ER, 2010)
"Many pediatricians recommend, and many parents administer, alternating or combined doses of ibuprofen and acetaminophen for fever."5.14Efficacy of standard doses of Ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children. ( Berlin, CM; Engle, L; Paul, IM; Sturgis, SA; Watts, H; Yang, C, 2010)
"Methods A prospective, randomized double-blind placebo control study comparing the efficacy of acetaminophen to acetaminophen alternated with ibuprofen in 38 healthy outpatient children 6 months to 6 years presenting to the outpatient clinic with fever >38 degrees C was conducted."5.13Alternating antipyretics: antipyretic efficacy of acetaminophen versus acetaminophen alternated with ibuprofen in children. ( Fairchok, MP; Harper, DP; Kramer, LC; Richards, PA; Thompson, AM, 2008)
"Acetaminophen and diphenhydramine are commonly used as pretransfusion medications to prevent transfusion reactions."5.13A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. ( Case, LD; Cruz, JM; Hurd, DD; Kennedy, LD; Pomper, GJ, 2008)
"To investigate whether paracetamol (acetaminophen) plus ibuprofen are superior to either drug alone for increasing time without fever and the relief of fever associated discomfort in febrile children managed at home."5.13Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. ( Costelloe, C; Fletcher, M; Hay, AD; Hollinghurst, S; Montgomery, AA; Peters, TJ; Redmond, NM, 2008)
"The Paracetamol (Acetaminophen) In Stroke (PAIS) study is a phase III multicenter, double blind, randomized, placebo-controlled clinical trial of high-dose acetaminophen in patients with acute stroke."5.13Correction: PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN74418480]. ( Algra, A; den Hertog, HM; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van der Worp, HB; van Gemert, HM; van Gijn, J, 2008)
"According to this study: In children younger than age two, treatment with ibuprofen was associated with reduced fever and less pain within the first 24 hours compared with acetaminophen."5.12Ibuprofen Better than Acetaminophen for Reducing Fever, Pain in Young Children. ( Rosenberg, K, 2021)
"Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever."5.12Paracetamol: unconventional uses of a well-known drug. ( Bloukh, S; Matheson, C; Wazaify, M, 2021)
"5 mg/kg per dose) and ibuprofen (5 mg/kg per dose) every 4 hours for 3 days, regardless of the initial loading medication, is more effective than monotherapy in lowering fever in infants and children."5.12Antipyretic treatment in young children with fever: acetaminophen, ibuprofen, or both alternating in a randomized, double-blind study. ( Cohen, HA; Sarrell, EM; Wielunsky, E, 2006)
"A randomised open label study of the combined use of paracetamol and ibuprofen to rapidly reduce fever is reported."5.12Randomised controlled trial of combined paracetamol and ibuprofen for fever. ( Benger, JR; Chinnick, PJ; Coppens, K; Davies, P; Erlewyn-Lajeunesse, MD; Higginson, IM; Hunt, LP, 2006)
"Propacetamol is an acetaminophen prodrug that was available in Europe as an IV formu lation for the treatment of pain and fever for some time."5.12Antipyretic efficacy and tolerability of a single intravenous dose of the acetaminophen prodrug propacetamol in children: a randomized, double-blind, placebo-controlled trial. ( Chesney, R; Jones, J; Rodarte, A; Walson, PD, 2006)
"An intravenous formulation of paracetamol and an intravenous formulation of propacetamol (prodrug of paracetamol) were compared in children with acute fever due to infection in order to determine the antipyretic efficacy and safety during the 6-hour period after administration."5.12Antipyretic efficacy and safety of a single intravenous administration of 15 mg/kg paracetamol versus 30 mg/kg propacetamol in children with acute fever due to infection. ( Dalphin, ML; Duhamel, JF; Le Gall, E; Payen-Champenois, C, 2007)
"Children from the age of 3 months to 12 years with a fever of non-serious origin were randomized to receive either ibuprofen or paracetamol."5.12Ibuprofen versus paracetamol in pediatric fever: objective and subjective findings from a randomized, blinded study. ( Autret-Leca, E; Gibb, IA; Goulder, MA, 2007)
"In the majority of patients with acute ischemic stroke, ASA and acetaminophen are insufficient for reducing an elevated BT to a state of normothermia."5.11Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke. ( De Keyser, J; Elting, JW; Luijckx, GJ; Luyckx, GJ; Maurits, N; Sulter, G, 2004)
"To determine whether evidence in the medical literature supports ibuprofen or acetaminophen for reducing fever in children."5.11The antipyretic effect of ibuprofen and acetaminophen in children. ( Wahba, H, 2004)
"Acetaminophen prophylaxis prevented neither maternal hyperthermia nor fever secondary to epidural analgesia, suggesting that the mechanism underlying fever does not include centrally mediated perturbations of maternal thermoregulation."5.11Prophylactic acetaminophen does not prevent epidural fever in nulliparous women: a double-blind placebo-controlled trial. ( Citron, DR; Evans, T; Goetzl, L; Lieberman, E; Richardson, BE; Rivers, J; Suresh, MS, 2004)
"Aspirin (acetylsalicylic acid) and acetaminophen (paracetamol) are frequently used to treat fever and other symptoms of upper respiratory tract infection (URTI)."5.11Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging st ( Bachert, C; Chuchalin, AG; Eisebitt, R; Netayzhenko, VZ; Voelker, M, 2005)
"To compare the antipyretic and hemodynamic effects of metamizol and propacetamol in critically ill patients with fever."5.10[Metamizol versus propacetamol: comparative study of the hemodynamic and antipyretic effects in critically ill patients]. ( Cruz, P; Díaz, S; Fernández-Quero, L; Garutti, I, 2002)
" In a previous randomized trial we observed that treatment with high-dose acetaminophen (paracetamol) led to a reduction of body temperature in patients with acute ischemic stroke, even when they had no fever."5.10Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2003)
"Early administration of acetaminophen (3900 mg/d) to afebrile patients with acute stroke may result in a small reduction in CBT."5.10Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial. ( Chalela, JA; Grotta, JC; Kasner, SE; Kimmel, SE; Krieger, DW; Morgenstern, LB; Piriyawat, P; Villar-Cordova, CE; Wein, T, 2002)
"Rather than supporting the hypothesis that ibuprofen increases asthma morbidity among children who are not known to be sensitive to aspirin or other nonsteroidal antiinflammatory drugs, these data suggest that compared with acetaminophen, ibuprofen may reduce such risks."5.10Asthma morbidity after the short-term use of ibuprofen in children. ( Lesko, SM; Louik, C; Mitchell, AA; Vezina, RM, 2002)
"Acetaminophen was the superior antipyretic drug in endotoxemia compared with aspirin."5.09Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial. ( Bieglmayer, C; Eichler, HG; Jilma, B; Kapiotis, S; Pernerstorfer, T; Schmid, R, 1999)
"To compare the incidence of serious adverse clinical events among children <2 years old given ibuprofen and acetaminophen to control fever."5.09The safety of acetaminophen and ibuprofen among children younger than two years old. ( Lesko, SM; Mitchell, AA, 1999)
"The purpose of this preliminary study was to compare acetaminophen to ketorolac for treating patients with fever in the emergency department (ED)."5.09Ketorolac versus acetaminophen for treatment of acute fever in the emergency department. ( Ernst, A; Houry, D; Ledbetter, M; Weiss, S, 1999)
"The aim of this study was to assess and compare the efficacy and tolerability of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections (URTIs)."5.09Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections. ( Cin, S; Köksal, Y; Ulukol, B, 1999)
"Current acetaminophen (APAP) formulations approved for antipyretic use in children require up to five doses/day, which compromise compliance and risk breakthrough fever over 4 hours after dosing."5.09Acetaminophen controlled-release sprinkles versus acetaminophen immediate-release elixir in febrile children. ( Brown, RD; Donahue, L; Helms, R; Pickering, BD; Wilson, JT, 2000)
"The objectives of this prospective non-concurrent cohort study were to confirm the efficacy of vaginal misoprostol for early pregnancy termination and to determine whether the incidence of side effects is lower with prophylactic loperamide and acetaminophen."5.09Early pregnancy termination with vaginal misoprostol combined with loperamide and acetaminophen prophylaxis. ( Harwood, B; Jain, JK; Meckstroth, KR; Mishell, DR, 2001)
"Seventy-five patients with acute ischemic stroke confined to the anterior circulation were randomized to treatment with either 500 mg (low dose) or 1000 mg (high dose) acetaminophen or with placebo, administered as suppositories 6 times daily during 5 days."5.09Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial. ( Dippel, DW; Kappelle, LJ; Koudstaal, PJ; Meijer, RJ; van Breda, EJ; van der Worp, HB; van Gemert, HM, 2001)
"An initial 30-mg/kg acetaminophen loading dose seemed to be more effective in reducing fever than a 15-mg/kg maintenance dose."5.09Antipyretic efficacy of an initial 30-mg/kg loading dose of acetaminophen versus a 15-mg/kg maintenance dose. ( d'Athis, P; Jolivet-Landreau, I; Leclerc, B; Pons, G; Tonnelier, S; Tréluyer, JM, 2001)
"This study compared the antipyretic effectiveness of acetaminophen, ibuprofen, and dipyrone in young children with fever."5.09Antipyretic effects of dipyrone versus ibuprofen versus acetaminophen in children: results of a multinational, randomized, modified double-blind study. ( Barragán, S; Campos, S; De León González, M; Escobar, AM; Ferrero, F; Kesselring, GL; Plager, M; Santolaya, ME; Sibbald, A; Wong, A, 2001)
"Infusion-related adverse events (IRAEs) such as nausea, vomiting, fever, chills, and thrombophlebitis that are associated with amphotericin B therapy often lead clinicians to prescribe a number of adjunctive pretreatment medications in an attempt to reduce the incidence and severity of these events."5.08Pretreatment regimens for adverse events related to infusion of amphotericin B. ( Cleary, JD; Goodwin, SD; Grasela, TH; Taylor, JW; Walawander, CA, 1995)
"5 mg/kg per dose), aspirin (10 mg/kg/dose) and paracetamol (10 mg/kg per dose) on children with fever aged 6-24 months in an open, randomised study with three parallel groups."5.08Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever. ( Autret, E; Courcier, S; Goehrs, JM; Henry-Launois, B; Laborde, C; Languillat, G; Launois, R; Reboul-Marty, J, 1997)
" Children with a febrile illness were enrolled from outpatient pediatric and family medicine practices and randomly assigned to receive either acetaminophen suspension or one of two dosages of ibuprofen suspension (5 mg/kg or 10 mg/kg) for fever control."5.08Renal function after short-term ibuprofen use in infants and children. ( Lesko, SM; Mitchell, AA, 1997)
"The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever."5.07A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children. ( Comito, A; Pieragostini, P; Polidori, G; Scaricabarozzi, I; Titti, G, 1993)
"This study defines what degree of respiratory rate (RR) elevation can be attributed to fever using a double blind randomized pre- and post-acetaminophen comparison of vital signs of febrile children presenting to an outpatient clinic."5.07Correcting respiratory rate for the presence of fever. ( Gadomski, AM; Permutt, T; Stanton, B, 1994)
"The objective of this study was to determine whether paracetamol (acetaminophen) affects the outcome of children with fever due to bacterial infectious disease."5.07Risks of antipyretics in young children with fever due to infectious disease. ( Asakuno, Y; Fujimoto, T; Hayakawa, H; Korematu, S; Maruoka, T; Motoyama, H; Sugimura, T, 1994)
"The authors studied the antipyretic effect of three intramuscular doses of ketorolac (15, 30, and 60 mg), acetaminophen 650 mg PO, and placebo in healthy male volunteers using an endotoxin-induced fever model."5.07Evaluation of the antipyretic effect of ketorolac, acetaminophen, and placebo in endotoxin-induced fever. ( Bynum, L; Maneatis, T; McMahon, FG; Peterson, C; Vargas, R, 1994)
" All patients had evaluations performed for fever reduction, use of acetaminophen for temperature > or = 38."5.07Efficacy and safety of aerosolized ribavirin in young children hospitalized with influenza: a double-blind, multicenter, placebo-controlled trial. ( Arrobio, J; Groothuis, JR; Hall, CB; Johnson, G; Rodriguez, WJ; Ryan, ME; Simoes, EA; Stutman, H; Van Dyke, R; Welliver, R, 1994)
"kg-1 acetaminophen syrup (n = 77) in 154 children (6 months to 5 years) with fever (> or = 38 degrees C) associated with infectious diseases and treated with antibiotic therapy."5.07Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics. ( Autret, E; Breart, G; Courcier, S; Goehrs, JM; Jonville, AP; Lassale, C, 1994)
"5-, 5-, or 10-mg/kg ibuprofen therapy via a liquid or 15-mg/kg acetaminophen therapy via an elixir every 6 hours for 24 to 48 hours show equivalent fever reduction or suffer adverse effects of the drug administered."5.07Comparison of multidose ibuprofen and acetaminophen therapy in febrile children. ( Braden, NJ; Chomilo, F; Galletta, G; Sawyer, LA; Scheinbaum, ML; Walson, PD, 1992)
"A double-blind, parallel-group, triple-dummy-designed, single-oral-dose study compared the efficacy, tolerability, safety, and dose-response of 5 mg/kg (n = 32) and 10 mg/kg (n = 28) ibuprofen suspension, 10 mg/kg acetaminophen elixir (n = 33), and placebo liquids (n = 34) in 127 children (2 to 11 years of age) with fever (101 degrees to 104 degrees F)."5.06Ibuprofen, acetaminophen, and placebo treatment of febrile children. ( Alexander, L; Braden, NJ; Galletta, G; Walson, PD, 1989)
"The effectiveness of acetaminophen in preventing post-vaccination fever was studied in a double-blind randomized manner."5.06Effect of prophylactic acetaminophen administration on reaction to DTP vaccination. ( Hietala, J; Uhari, M; Viljanen, MK, 1988)
"The effect of acetaminophen on fever in bacterial vs."5.06Fever response to acetaminophen in viral vs. bacterial infections. ( Brien, JH; Miller, G; Weisse, ME, 1987)
"Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children."5.05Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis. ( Braithwaite, I; Dalziel, SR; McKinlay, CJD; Tan, E, 2020)
"Acetaminophen serum concentrations were studied in 21 infants and children with fever."5.05Acetaminophen accumulation in pediatric patients after repeated therapeutic doses. ( Durrell, DE; Miller, MA; Nahata, MC; Powell, DA, 1984)
"The present randomized single-blind trial was performed to study antipyretic effect and tolerability of alpha-methyl-4-(2-thienylcarbonyl)-phenyl acetic acid (suprofen, Suprol) suppositories versus paracetamol (acetaminophen) suppositories in pediatric patients with fever of various etiology."5.05Clinical experience and results of treatment with suprofen in pediatrics. 2nd communication: Use of suprofen suppositories as an antipyretic in children with fever due to acute infections/A single-blind controlled study of suprofen versus paracetamol. ( Michos, N; Stocker, H; Sundal, EJ; Weippl, G, 1985)
"- Paracetamol or ibuprofen should only be given when there is a combination of fever and pain."4.95[Revision of the Dutch College of General Practitioners practice guideline 'Children with fever']. ( Eizenga, WE; Opstelten, W, 2017)
" Paracetamol and ibuprofen are the most commonly used interventions to manage fever in children; however, there have been no comparative analyses."4.95Effectiveness of paracetamol versus ibuprofen administration in febrile children: A systematic literature review. ( Cooper, S; Innes, K; Morphet, J; Narayan, K, 2017)
" The aim of this review is to determine if there are any clinically relevant differences in safety between ibuprofen and paracetamol that may recommend one agent over the other in the management of fever and discomfort in children older than 3 months of age."4.95A clinical and safety review of paracetamol and ibuprofen in children. ( Kanabar, DJ, 2017)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."4.93Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016)
"Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever in children."4.90Paracetamol: a focus for the general pediatrician. ( Barbi, E; Guarino, S; Marzuillo, P, 2014)
"Health professionals frequently recommend fever treatment regimens for children that either combine paracetamol and ibuprofen or alternate them."4.90Combined and alternating paracetamol and ibuprofen therapy for febrile children. ( Ganshorn, H; Hartling, L; Johnson, DW; Maconochie, IK; Stang, AS; Thomsen, AM; Wong, T, 2014)
"Combination treatment with ibuprofen and acetaminophen is beneficial over either agent alone for sustained fever reduction in children older than 6 months."4.89Does combination treatment with ibuprofen and acetaminophen improve fever control? ( Malya, RR, 2013)
"Health professionals frequently recommend fever treatment regimens for children that either combine paracetamol and ibuprofen or alternate them."4.89Combined and alternating paracetamol and ibuprofen therapy for febrile children. ( Ganshorn, H; Hartling, L; Johnson, DW; Maconochie, IK; Stang, AS; Thomsen, AM; Wong, T, 2013)
" In paediatric populations, ibuprofen and paracetamol (acetaminophen) are both commonly used over-the-counter medicines for the management of fever or mild-to-moderate pain associated with sore throat, otitis media, toothache, earache and headache."4.89Optimising the management of fever and pain in children. ( van den Anker, JN, 2013)
"To analyse major sources of evidence-based information on the efficacy and gastrointestinal tolerability of aspirin, used short-term, in over-the-counter (OTC) doses, to relieve acute pain and cold symptoms, including associated feverishness."4.88Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold. ( McCarthy, DM, 2012)
"To evaluate the evidence surrounding the use of combinations of paracetamol and ibuprofen in the treatment of fever."4.87Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone. ( Purssell, E, 2011)
"Acetylsalicylic acid (ASA [aspirin]) is a commonly used over-the-counter drug for the treatment of pain, fever, or colds, but data on the safety of this use are very limited."4.87Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials. ( Baron, JA; Brueckner, A; Lanas, A; McCarthy, D; Senn, S; Voelker, M, 2011)
"Ibuprofen is as or more efficacious than acetaminophen for the treatment of pain and fever in adult and pediatric populations and is equally safe."4.86Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review. ( Pierce, CA; Voss, B, 2010)
"Paracetamol and ibuprofen are safe and effective medications for reducing a fever in children and young people and they are often administered together with a view to reducing a temperature quickly."4.86Fever management: evaluating the use of ibuprofen and paracetamol. ( Crook, J, 2010)
"Intravenous paracetamol (rINN)/intravenous acetaminophen (USAN) is an analgesic and antipyretic agent, recommended worldwide as a first-line agent for the treatment of pain and fever in adults and children."4.85Intravenous paracetamol (acetaminophen). ( Duggan, ST; Scott, LJ, 2009)
"Schultz et al (2008) raised the question whether regression into autism is triggered, not by the measles-mumps-rubella (MMR) vaccine, but by acetaminophen (Tylenol) given for its fever and pain."4.85Did acetaminophen provoke the autism epidemic? ( Good, P, 2009)
"To determine, on the basis of published studies, the efficacy of rectal vs oral acetaminophen as treatment of fever and pain."4.84Effectiveness of oral vs rectal acetaminophen: a meta-analysis. ( Berkovitch, M; Berlin, M; Goldstein, LH; Kozer, E, 2008)
"To characterize clozapine-induced fever and suggest clinically relevant management recommendations."4.84Characterization and clinical management of clozapine-induced fever. ( Grube, RR; Lowe, CM; Scates, AC, 2007)
"Although many studies have investigated the safety and tolerability of ibuprofen or acetaminophen (paracetamol) use in children, few have specifically examined the association of ibuprofen or acetaminophen and the occurrence of asthma in pediatric populations."4.84A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. ( Dale, S; Kanabar, D; Rawat, M, 2007)
"This paper describes two studies in children with fever in which the safety of ibuprofen was compared with that of paracetamol."4.82The safety of ibuprofen suspension in children. ( Lesko, SM, 2003)
"Antipyretics, including acetaminophen (paracetamol), are prescribed commonly in children with pyrexia, despite minimal evidence of a clinical benefit."4.82Evidence on the use of paracetamol in febrile children. ( Curtis, N; Mulholland, K; Russell, FM; Shann, F, 2003)
"Ibuprofen was significantly more effective than acetaminophen in reducing fever after a single dose."4.82Antipyretic efficacy and safety of ibuprofen and acetaminophen in children. ( Goldman, RD; Ko, K; Linett, LJ; Scolnik, D, 2004)
"To summarize studies testing the efficacy and safety of single-dose acetaminophen and ibuprofen for treating children's pain or fever."4.82Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis. ( Champion, GD; Goodenough, B; Perrott, DA; Piira, T, 2004)
"Paracetamol (acetaminophen) is widely used for treating fever in children."4.81Paracetamol for treating fever in children. ( Meremikwu, M; Oyo-Ita, A, 2002)
"Paracetamol (acetaminophen) has a unique role in children because it is the first-line choice for the treatment of both fever and pain."4.80Paracetamol efficacy and safety in children: the first 40 years. ( Coghlan, D; Cranswick, N, 2000)
"Paracetamol (acetaminophen) is one of the most widely used of all drugs, with a wealth of experience clearly establishing it as the standard antipyretic and analgesic for mild to moderate pain states."4.80Paracetamol: past, present, and future. ( Prescott, LF, 2000)
"Paracetamol (acetaminophen) is recommended as a first-line drug in the management of pain and pyrexia in humans due to its minor gastrointestinal, renal and vascular side effects."4.31Current perceptions and use of paracetamol in dogs among veterinary surgeons working in the United Kingdom. ( Bello, AM; Dye, C, 2023)
"Paracetamol 1,000 mg represents the first choice for the treatment of fever in the ED, followed by Paracetamol/Ibuprofen 500/150 mg."4.31Treatment of fever and associated symptoms in the emergency department: which drug to choose? ( Candelli, M; Carnicelli, A; Covino, M; Franceschi, F; Lorusso, C; Novelli, A; Ojetti, V; Saviano, A, 2023)
"The use of intravenous (IV) acetaminophen (APAP) for fever has not been thoroughly studied in neurocritical care (NCC) patients, in whom a temperature of ≥38°C is associated with poor outcomes and treatment to normothermia is common practice."4.12Intravenous Versus Oral Acetaminophen Use in Febrile Neurocritical Care Patients. ( Brophy, GM; D'Eramo, RE; Nadpara, PA; Sandler, M; Taylor, PD, 2022)
"Intravenous propacetamol is commonly used to control fever and pain in neurocritically ill patients in whom oral administration is often difficult."4.12Risk Factors for Intravenous Propacetamol-Induced Blood Pressure Drop in the Neurointensive Care Unit: A Retrospective Observational Study. ( Han, MK; Jeon, S; Jeong, HG; Lee, E; Lee, J; Lee, JY; Song, YJ, 2022)
"This study was undertaken to evaluate the efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen in comparison with as-needed acetaminophen alone for prevention of seizure recurrence during the same fever episode in suspected pediatric simple febrile seizures (SFS)."4.12Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures. ( Fujita, S; Hataya, H; Kishibe, S; Miyama, S; Morikawa, EK; Morikawa, Y; Narita, K; Sammori, H; Suzuki, S; Takehira, K; Tanaka, M; Tsukamoto, J; Wang, Q; Yano, M, 2022)
"We describe a case of a 5-year-old female with stage III Wilms tumor who had recurrent VCR-associated fever that was controlled with prophylactic dexamethasone and acetaminophen."4.12Recurrent vincristine-associated fever in a child with Wilms tumor. ( Al-Antary, ET; Ramiz, S, 2022)
" One hundred and seventy-nine (44%) patients had fever, with 32% using paracetamol and 22% using ibuprofen, for symptom-relief."3.96Ibuprofen use and clinical outcomes in COVID-19 patients. ( Bar-Haim, A; Kozer, E; Rinott, E; Shapira, Y; Youngster, I, 2020)
"Paracetamol (acetaminophen) is widely used for management of mild-to-moderate pain and reduction of fever."3.91Efficacy and safety of modified-release paracetamol for acute and chronic pain: a systematic review protocol. ( Dosenovic, S; Margan Koletic, Z; Puljak, L, 2019)
"We retrospectively reviewed the medical records of the patients with laboratory-confirmed influenza A who received intravenous propacetamol for the control of fever in the ED during the 2015-16 influenza season."3.88Hemodynamic changes in patients with influenza A after propacetamol infusion in the emergency department. ( Durey, A; Han, SB; Kim, AJ; Lee, HJ; Suh, YJ, 2018)
"Clinical studies have indicated that transient hypotension can occur after propacetamol administration."3.88Hemodynamic changes after propacetamol administration in patients with febrile UTI in the ED. ( Durey, A; Kang, S; Kim, AJ; Suh, YJ, 2018)
"All children who received acetaminophen or had a fever (temperature ≥ 38°C) while on the ICU over a 40-month period (September 2012 to December 2015)."3.88The Effect of Acetaminophen on Temperature in Critically Ill Children: A Retrospective Analysis of Over 50,000 Doses. ( Brown, KL; Peters, MJ; Ray, S; Rogers, L, 2018)
" In 1980 s, the relevance of aspirin for Reye's syndrome became a problem, then acetaminophen came into use for various kinds of cases such as children, pregnant women and the elderly for pain management or alleviation of fever."3.83[Side Effects of Acetaminophen and their Management]. ( Saeki, S, 2016)
"Our study shows that preventive action should be taken regarding the use of acetaminophen as antipyretic drug in children in order to reduce the fever phobia and self-prescription, especially of caregivers with higher educational levels."3.83Acetaminophen administration in pediatric age: an observational prospective cross-sectional study. ( Bonci, M; Cecchetti, C; Di Ruzza, L; Falsaperla, R; Gentile, I; Lubrano, R; Matin, N; Paoli, S; Pavone, P; Vitaliti, G, 2016)
"The pharmacological specificities of the rectal formulation of acetaminophen led to a debate on its appropriateness for managing fever in children, but few data are available on the formulation's current use and determinants of use."3.83Enduring large use of acetaminophen suppositories for fever management in children: a national survey of French parents and healthcare professionals' practices. ( Bertille, N; Chalumeau, M; Fournier-Charrière, E; Khoshnood, B; Pons, G, 2016)
"Acetaminophen is a commonly used medication to manage fever and pain in children and the drug is generally considered to be safe when used at appropriate therapeutic dosages."3.81Severe intrinsic acute kidney injury associated with therapeutic doses of acetaminophen. ( Aizawa, T; Hirono, K; Ito, E; Ito, T; Joh, K; Tanaka, H; Tsuruga, K; Watanabe, S, 2015)
"The primary objective was to assess whether patients with a fever are treated with acetaminophen or ibuprofen more promptly than they are treated for pain."3.80Is fever treated more promptly than pain in the pediatric emergency department? ( Bair, J; Dvorkin, R; Glantz, S; Marguilies, J; Patel, H; Rosalia, A; Yens, DP, 2014)
"Treatment of pediatric fever is based on two main molecules, paracetamol and ibuprofen."3.80[How to treat pediatric fever in 2013 with little evidence-based?]. ( Gehri, M; Pauchard, JY, 2014)
"High anion gap metabolic acidosis due to pyroglutamic acid (5-oxoproline) is a rare complication of acetaminophen treatment (which depletes glutathione stores) and is often associated with clinically moderate to severe encephalopathy."3.80Pyroglutamic acid-induced metabolic acidosis: a case report. ( Dive, A; Galanti, L; Luyasu, S; Wamelink, MM, 2014)
"Health-care professionals frequently recommend fever treatment regimens for children who either combine paracetamol and ibuprofen or alternate them."3.80Cochrane in context: Combined and alternating paracetamol and ibuprofen therapy for febrile children. ( Ganshorn, H; Hartling, L; Johnson, DW; Maconochie, IK; Stang, AS; Thomsen, AM; Wong, T, 2014)
"Acetaminophen is one of the world's most commonly used drugs to treat fever and pain, yet its mechanism of action has remained unclear."3.79Acetaminophen reduces lipopolysaccharide-induced fever by inhibiting cyclooxygenase-2. ( Blomqvist, A; Elander, L; Engblom, D; Engström Ruud, L; Eskilsson, A; Vasilache, AM; Wilhelms, DB, 2013)
" Nevertheless, the anti-inflammatory activity was tested in carrageenan induced paw edema and histamine induced inflammatory tests."3.78Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. ( Khan, H; Muhammad, N; Saeed, M, 2012)
"Children who have unresolved pain despite the use of either ibuprofen or acetaminophen should have their medication regimen reviewed to ensure they are receiving the medication at an adequate dose and interval."3.78Alternating acetaminophen and ibuprofen for pain in children. ( Goldman, RD; Smith, C, 2012)
"This study aims to explore the knowledge of a randomly selected cohort of Iranian general practitioners (GPs) on the topic of acetaminophen dosing for fever in children."3.78Knowledge of Iranian general practitioners for acetaminophen dosing in children. ( Bagheri, M; Mirmoghtadaee, P; Sabzghabaee, AM; Soltani, R, 2012)
"We performed a retrospective study of medical intensive care unit and surgical intensive care unit patients with systemic inflammatory response syndrome and compared the resolution of fever in the presence and absence of acetaminophen treatment by comparing the absolute reduction in body temperature and the rate of cooling over comparable time frames in fevers that were untreated and those treated with acetaminophen."3.76Acetaminophen has limited antipyretic activity in critically ill patients. ( Chen, H; Greenberg, RS; Hasday, JD, 2010)
"Acetaminophen use in children has been associated with increased autism risk."3.76Can autism be triggered by acetaminophen activation of the endocannabinoid system? ( Schultz, ST, 2010)
"001) dose-dependent analgesic effect in the tail flick, hot plate, and tail clip (central) as well as in acetic acid-induced writhing (peripheral) nociceptive tests in mice, suggesting the involvement of both central and peripheral mechanisms in alleviating the pain response."3.76Analgesic and antipyretic activities of ethanol extract of Stereospermum suaveolens. ( Kumar, CT; Mpharm, TB, 2010)
"To investigate the effect of intravenous propacetamol, a parenteral bioprecursor of acetaminophen, on systemic blood pressure in critically ill patients with fever, and to establish the prevalence and clinical significance of this effect."3.74Effect of intravenous propacetamol on blood pressure in febrile critically ill patients. ( Hersch, M; Izbicki, G; Raveh, D, 2008)
"The inclusion criteria were age between 3 and 36 months, main complaint of fever and at least one dose of dipyrone or acetaminophen given to the child during the 24 hours preceding their arrival at the emergency department."3.74Dipyrone and acetaminophen: correct dosing by parents? ( Almeida, CD; Almeida, ND; Alves, JG; Cardoso Neto, FJ, 2007)
"To report Australian parents' medication (paracetamol, ibuprofen and homeopathic) use in childhood fever management."3.74Over-the-counter medication use for childhood fever: a cross-sectional study of Australian parents. ( Edwards, H; Fraser, J; Walsh, A, 2007)
" Two days prior to the incident, the twins had received the second dose of oral polio, DPT and the first dose of hepatitis B vaccines and they had fever on the first day of the vaccination and been given teaspoonful of acetaminophen."3.74Simultaneous sudden infant death syndrome. ( Balci, Y; Kocaturk, BK; Tok, M; Yenilmez, C; Yirulmaz, C, 2007)
"Acetaminophen is an effective mild analgesic and antipyretic agent."3.74Acetaminophen. ( Ameer, B; Greenblatt, DJ, 1977)
" However, due to its side effects, ibuprofen should be used only in high and badly tolerated fever that is not altered by a well conducted acetaminophen monotherapy."3.73[Familial use of ibuprofen in febrile children: a prospective study in the emergency room of an hospital in Lille]. ( Charkaluk, ML; El Kohen, R; Kalach, N; Kremp, O, 2005)
"Paracetamol (Acetaminophen) In Stroke (PAIS) is a randomized, double-blind clinical trial, comparing high-dose acetaminophen with placebo in 2500 patients."3.73PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial [ISCRTN 74418480]. ( Algra, A; Dippel, DW; Kappelle, LJ; Koudstaal, PJ; van Breda, EJ; van der Worp, HB; van Gemert, HM; van Gijn, J, 2005)
"Children frequently suffer infections accompanied by fever, which is commonly treated with acetaminophen (paracetamol), a use not devoid of risk."3.73The effects of a complex homeopathic medicine compared with acetaminophen in the symptomatic treatment of acute febrile infections in children: an observational study. ( Derasse, M; Klein, P; Weiser, M, 2005)
"The results of this survey concerning antipyretic treatment of children by their Jewish and Bedouin Moslem caregivers suggest that lighter body weight and the use of acetaminophen rectal suppositories were associated with the administration of higher-than-recommended doses of acetaminophen."3.73Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. ( Bilenko, N; Gorodischer, R; Okbe, R; Press, J; Tessler, H, 2006)
"We have previously shown that both chloroquine and paracetamol (acetaminophen) have antipyretic activity during treatment of acute uncomplicated Plasmodium falciparum malaria in children 1-4 years old."3.73Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes. ( Björkman, A; Hugosson, E; Montgomery, SM; Premji, Z; Troye-Blomberg, M, 2006)
"The present study was designed to determine whether the inhibition of glutamate release in organum vasculosum laminae terminalis (OVLT) of rabbit brain by acetaminophen might be protective in a whole-animal model of staphylococcal enterotoxin A (SEA) fever."3.72Antipyretic effect of acetaminophen by inhibition of glutamate release after staphylococcal enterotoxin A fever in rabbits. ( Huang, WT; Lin, MT; Wang, JJ, 2004)
"A cross-sectional study including 248 caregivers of children who had a chief complaint of fever and had been given acetaminophen in the preceding 24 hours were interviewed."3.72Underdosing of acetaminophen by parents and emergency department utilization. ( Goldman, RD; Scolnik, D, 2004)
" Nonetheless, these data suggest that parents use ibuprofen or ibuprofen together with acetaminophen to treat high fever and severe illness, which seems to identify children at high risk for invasive GAS infection."3.71Invasive group A streptococcal infection and nonsteroidal antiinflammatory drug use among children with primary varicella. ( Lesko, SM; Mitchell, AA; O'Brien, KL; Schwartz, B; Vezina, R, 2001)
" Predictive factors of this practice among pediatricians are male sex, having relatively little experience, considering ibuprofen as the drug of choice and recommending the administration of new doses of antipyretic to control mild fever."3.71[Use of alternating antipyretics in the treatment of fever in Spain]. ( Ballester Sanz, A; Burgos Ramírez, A; Díez Domingo, J; Garrido García, J; Moreno Carretero, E, 2001)
"Seventy-five (3 x 25) patients with acute ischaemic stroke confined to the anterior circulation will be randomised to treatment with either: 400 mg ibuprofen, 1000 mg acetaminophen, or with placebo 6 times daily during 5 days."3.71PISA. The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: protocol for a phase II double-blind randomised placebo-controlled trial [ISRCTN98608690]. ( Dippel, DW; Kappelle, J; Koudstaal, PJ; Meijer, R; van Breda, EJ; van der Worp, B; van Gemert, M, 2002)
" Fever always occurred before their admission and aspirin (n = 12) or acetaminophen (n = 7) was prescribed."3.71[Severe Reye syndrome: report of 14 cases managed in a pediatric intensive care unit over 11 years]. ( Brivet, M; Chevret, L; Debray, D; Devictor, D; Durand, P; Fabre, M; Thabet, F, 2002)
"A cohort of 484 febrile children were examined to (1) assess the utility of temperature response to acetaminophen as a diagnostic test for occult bacteremia (OB) and (2) compare it with the white blood cell (WBC) count."3.69Diagnostic tests for occult bacteremia: temperature response to acetaminophen versus WBC count. ( Kozinetz, CA; Mazur, LJ, 1994)
"We have investigated the effect of malaria infection with the rodent parasite Plasmodium berghei and fever induced by Escherichia coli endotoxin on the metabolism of phenacetin to paracetamol by rat liver microsomes from young (4 weeks old) male Wistar rats (N = 5 in control and fever groups; N = 10 in malaria-infected group)."3.68Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes. ( Breckenridge, AM; Edwards, G; Glazier, AP; Kokwaro, GO; Ward, SA, 1993)
"Orders for acetaminophen prn (as needed), without further explanation, were interpreted by the nursing staff as antipyretic orders; 78% of patients with such an order and fever received acetaminophen during the febrile episode."3.68Antipyretic orders in a university hospital. ( Axelrod, PI; Isaacs, SN; Lorber, B, 1990)
"Centrally administered alpha-melanocyte stimulating hormone is much more potent in reducing fever than the widely used antipyretic acetaminophen."3.66Antipyretic potency of centrally administered alpha-melanocyte stimulating hormone. ( Lipton, JM; Murphy, MT; Richards, DB, 1983)
"An animal model used yeast-fevered rats to measure the relative antipyretic effects of different commercially available acetaminophen-containing suppositories."3.66Antipyretic effect of acetaminophen suppositories in rats. ( Ayres, J; Eckman, BM; Lock, A, 1979)
"The capacity of N-(2,3-xylyl)anthranilic acid (mefenamic acid) to reduce fever in children was compared with that of acetylsalicylic acid, paracetamol and amino-phenazone."3.65Oral antipyretic therapy. Evaluation of mefenamic acid (short communication). ( Keinänen, S; Kouvalainen, K; Similä, S, 1977)
"The capacity of ibuprofen to reduce fever in children was compared with that of aspirin, paracetamol, aminophenazone and indomethacin."3.65Oral antipyretic therapy. ( Keinänen, S; Kouvalainen, K; Similä, S, 1976)
"Fever is the most common reason for children's visits to medical centers."3.11Comparing the effect of body wash with marshmallow plant and lukewarm water on reducing the temperature of febrile children: a randomized clinical trial. ( Delfan, B; Ebrahimzade, F; Ghasemi, F; Goodarzi, H; Seifosadat, SH; Taee, N; Valizadeh, F, 2022)
" Globally, the pharmacologic treatment of pain in pediatric patients is limited largely to nonopioid analgesics, and dosing must account for differences in age, weight, metabolism, and risk of adverse effects."3.01Common Selfcare Indications of Pain Medications in Children. ( Bell, J; Kachroo, P; Mossali, VM; Siddiqui, K; Zempsky, W, 2023)
"Fever is the most common reason for the presentation of children in the outpatient department."3.01Randomised comparative trial of the efficacy of paracetamol syrup and dispersible tablets for the treatment of fever in children. ( Bisi-Onyemaechi, A; Ibeleme, O; Okereke, B, 2021)
"Dengue is a common cause of acute liver failure in tropical countries."2.90Effect of standard dose paracetamol versus placebo as antipyretic therapy on liver injury in adult dengue infection: a multicentre randomised controlled trial. ( Changpradub, D; Chuerboonchai, W; Jitsiri, S; Lertliewtrakool, N; Niyasom, S; Rojdumrongrattana, T; Siriwiwattana, T; Thongtaeparak, W; Vasikasin, V, 2019)
"A clinical pharmacokinetic study in adult patients with TBI was performed as a sub-study to a prospective, phase 2B, randomized placebo-controlled study (PARITY)."2.87Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury. ( Gowardman, J; Lipman, J; Myburgh, J; Parker, SL; Roberts, JA; Saxena, M, 2018)
"Low grade fever is a known adverse effect of vaccination."2.84Effect of prophylactic or therapeutic administration of paracetamol on immune response to DTwP-HepB-Hib combination vaccine in Indian infants. ( Bavdekar, SB; Chhatwal, J; D'Cor, NA; Dhaded, SM; Dhingra, MS; Dubey, AP; Dupuy, M; Gandhi, DJ; Gupta, M; Jayanth, MV; Kundu, R; Lalwani, SK; Mangarule, SA; Mathew, LG; Patnaik, BN; Ravi, MD; Ravinuthala, S; Reddy E, J; Rout, SP; Sharma, SD; Sil, A, 2017)
"To assess the safety and feasibility of treating critically ill adults with different fever control strategies."2.78Assessment of the safety and feasibility of administering antipyretic therapy in critically ill adults: a pilot randomized clinical trial. ( Kubes, P; Laupland, KB; Léger, C; Niven, DJ; Stelfox, HT, 2013)
"Pain, swelling, infection, trismus and temperature were recorded on days 3, 7 and 14 after surgery."2.75Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique. ( Morkel, JA; Siddiqi, A; Zafar, S, 2010)
"Fever is a common symptom in children and one of the major concerns of parents of younger and preschool-age children."2.75Ketoprofen versus paracetamol (acetaminophen) or ibuprofen in the management of fever: results of two randomized, double-blind, double-dummy, parallel-group, repeated-dose, multicentre, phase III studies in children. ( Kokki, H; Kokki, M, 2010)
"Fever was measured with the aid of a tympanic thermometer (Braun Kronberg 6014) and followed for 4-6 hours."2.74Antipyretic effect of ketoprofen. ( Akgoz, S; Arisoy, ES; Aygun, D; Celebi, S; Citak Kurt, AN; Hacimustafaoglu, M; Karali, Y; Seringec, M, 2009)
"Although fever is part of the normal inflammatory process after immunisation, prophylactic antipyretic drugs are sometimes recommended to allay concerns of high fever and febrile convulsion."2.74Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. ( Borys, D; Chlibek, R; Kaliskova, E; Lommel, P; Prymula, R; Schuerman, L; Siegrist, CA; Smetana, J; Vackova, M; Zemlickova, H, 2009)
" Our hypothesis was that common liver tests would be unaffected by administration of the maximum recommended daily dosage of acetaminophen for 3 consecutive days to newly-abstinent alcoholic subjects."2.73The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study. ( Bogdan, GM; Dart, RC; Green, JL; Heard, K; Knox, PC; Kuffner, EK; Palmer, RB; Slattery, JT, 2007)
"At physician-directed dosing (acetaminophen 15 mg/kg vs ibuprofen 10 mg/kg), no significant differences in antipyretic effects from 0‒6 h and between 0‒6, ‒12, ‒24, or ‒48 h, with single or multiple-doses, respectively, were observed."2.72Acetaminophen and ibuprofen in the treatment of pediatric fever: a narrative review. ( Paul, IM; Walson, PD, 2021)
" tables of normal and abnormal ranges of temperature, recommended temperature measurement techniques, dosage regimen of antipyretic drugs, guidelines to parents), justifying the implementation of a pharmaceutical follow-up."2.71When fever, paracetamol? Theory and practice in a paediatric outpatient clinic. ( Cotting, JQ; Di Paolo, ER; Djahnine, SR; Gehri, M; Guignard, E; Krahenbuhl, JD; Pannatier, A; Yersin, C, 2005)
"Aggressively treating fever in critically ill patients may lead to a higher mortality rate."2.71The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study. ( Alhaddad, A; Amortegui, J; Baracco, G; Cohn, SM; Dlugasch, L; Doherty, J; Dy, CJ; Elhaddad, A; Lasko, D; Li, P; Manning, RJ; Namias, N; Schulman, CI, 2005)
"Epidural fever is associated with maternal and fetal inflammation in the absence of neonatal infection."2.70Elevated maternal and fetal serum interleukin-6 levels are associated with epidural fever. ( Evans, T; Goetzl, L; Lieberman, E; Rivers, J; Suresh, MS, 2002)
"Although it is necessary to treat the cause of fever, if possible, symptomatic fever management is also important."2.70Symptomatic intravenous antipyretic therapy: efficacy of metamizol, diclofenac, and propacetamol. ( Korístek, Z; Mayer, J; Oborilová, A; Pospísil, Z, 2002)
"Severe infarcts and intracerebral hemorrhages caused temperature to rise, whereas initially increased temperature had no influence on stroke severity."2.70Stroke severity determines body temperature in acute stroke. ( Boysen, G; Christensen, H, 2001)
"Although fever is a host defense response that may benefit some critically ill patients, others may not tolerate the cardiovascular demands associated with fever."2.70Comparison of fever treatments in the critically ill: a pilot study. ( Henker, R; Kelso, L; Kerr, M; Kramer, DJ; Rogers, S; Sereika, S, 2001)
"Chronic hepatitis C was a frequent complication in patients treated for malignancy until the introduction of anti-HCV screening tests for blood donors."2.69Interferon treatment of chronic hepatitis C in patients cured of pediatric malignancies. ( Bortolotti, F; Brugiolo, A; Cesaro, S; Cusinato, R; Guido, M; Masiero, L; Petris, MG; Rossetti, F; Zanesco, L, 2000)
"falciparum malaria were treated with intravenous quinine and received either mechanical antipyresis alone (electric fanning, tepid sponging, and cool blankets) or in combination with paracetamol."2.68Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria. ( Brandts, CH; Graninger, W; Kremsner, PG; Ndjavé, M, 1997)
" The statistical analysis of the results confirmed that ibuprofen and paracetamol are equivalent with respect to the following criteria (1) time elapsed between dosing and the lowest temperature: 3."2.68Equivalent antipyretic activity of ibuprofen and paracetamol in febrile children. ( d'Athis, P; Debregeas, S; Olive, G; Pariente-Khayat, A; Pons, G; Vauzelle-Kervroëdan, F, 1997)
"Indomethacin was significantly quicker at clearing fever than acetaminophen (P < 0."2.67Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria. ( Looareesuwan, S; Wilairatana, P, 1994)
"At 2 months of age, 145 infants were randomized to receive either a two-component acellular pertussis vaccine [lymphocytosis-promoting factor (LPF)/filamentous hemagglutinin (FHA)] or standard whole-cell pertussis vaccine, each combined with diphtheria-tetanus toxoids, as their primary immunization series."2.67Primary immunization series for infants: comparison of two-component acellular and standard whole-cell pertussis vaccines combined with diphtheria-tetanus toxoids. ( Andrew, M; Feldman, S; Jones, L; Lamb, D; Meschievitz, C; Moffitt, JE; Perry, CS, 1993)
" Pharmacokinetic and pharmacodynamic analyses were performed with temperature as the effect parameter and mean acetaminophen, total ibuprofen, and ibuprofen stereoisomer concentrations over time."2.67Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetaminophen in febrile children. ( Cox, S; Edge, JH; Kelley, MT; Mortensen, ME; Walson, PD, 1992)
"Ibuprofen is a potent antipyretic agent and is a safe alternative for the selected febrile child who may benefit from antipyretic medication but who either cannot take or does not achieve satisfactory antipyresis with acetaminophen."2.67Antipyretic efficacy of ibuprofen vs acetaminophen. ( Kauffman, RE; Sawyer, LA; Scheinbaum, ML, 1992)
"Nimesulide was studied in comparison with paracetamol, according to a double-blind technique."2.67Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories. ( D'Apuzzo, V; Monti, T, 1992)
"Ibuprofen was evaluated as an antipyretic agent in 178 children (aged 3 months to 12 years) to compare dosage (5 vs 10 mg/kg), establish absolute efficacy (with a placebo control group), determine relative efficacy (ibuprofen vs acetaminophen), evaluate maximum efficacy, and identify potential confounding variables."2.67Single-dose, placebo-controlled comparative study of ibuprofen and acetaminophen antipyresis in children. ( Bertrand, KM; Brown, RD; Eichler, VF; Johnson, VA; Kearns, GL; Lowe, BA; Wilson, JT, 1991)
" Both plasma elimination half life and area under the plasma concentration time curve were significantly increased in neonates after suppository dosing compared with older children."2.67Pharmacokinetics of paracetamol after cardiac surgery. ( Booker, PD; Hopkins, CS; Underhill, S, 1990)
" A control of the actual rectal dosage scheme for repetitive applications is recommended and the combination of paracetamol with sedatives is to be discussed."2.64[On the antipyretic effect of paracetamol. Clinical investigation with two different forms of application (author's transl)]. ( Götte, R; Liedtke, R, 1978)
" The total amount of paracetamol and its metabolites excreted and the peak excretion rates were lower from the suppository bases than from the oral dosage forms."2.64Antipyretic therapy. Comparison of rectal and oral paracetamol. ( Hietula, M; Keinänen, S; Kouvalainen, K; Similä, S, 1977)
"Fever is a very common adaptive immune response in acute respiratory tract disorders during infancy."2.61Faster recovery and reduced paracetamol use - a meta-analysis of EPs 7630 in children with acute respiratory tract infections. ( Brandes-Schramm, J; Kamin, W; Lehmacher, W; Seifert, G; Zimmermann, A, 2019)
"Induction of fever is mediated by the release of pyrogenic cytokines (tumor necrosis factor α, interleukin 1, interleukin 6, and interferons)."2.55Paracetamol in fever in critically ill patients-an update. ( Chiumello, D; Gotti, M; Vergani, G, 2017)
"Acetaminophen is a commonly used pediatric medication that has recently been approved for intravenous use in the United States."2.52Intravenous acetaminophen use in pediatrics. ( Shastri, N, 2015)
"Fever is a common symptom of childhood infections that in itself does not require treatment."2.50A practical approach to the treatment of low-risk childhood fever. ( Kanabar, D, 2014)
"Dengue is a resurging mosquito-borne disease that is often contracted in U."2.49A review of dengue fever: a resurging tropical disease. ( Mangold, KA; Reynolds, SL, 2013)
"A standardized approach to dosing acetaminophen in pediatric populations was published in 1983."2.49Dosing and antipyretic efficacy of oral acetaminophen in children. ( Kuffner, EK; Temple, AR; Temple, BR, 2013)
"The selected studies showed great heterogeneity of participants, temperature for fever diagnosis, interventions (dose and dosing intervals) and assessed outcomes."2.48Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials. ( Dagostini, JM; Pereira, GL; Pizzol, Tda S, 2012)
"Acetaminophen has unique analgesic and antipyretic properties."2.46Intravenous acetaminophen. ( Jahr, JS; Lee, VK, 2010)
"Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects."2.45Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009)
"Fever is the most common problem in medical situations, but controversy still surrounds its benefit/ risk ratio for human beings."2.44[Using evidence-based nursing to explore the management of child fever]. ( Huang, MC; Wang, YM, 2008)
" The review establishes that aspirin, paracetamol and ibuprofen are safe in OTC doses and that there is no evidence for any difference between the medicines as regards efficacy and safety for treatment of colds and flu (except in certain cases such as the use of aspirin in feverish children)."2.43Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu. ( Eccles, R, 2006)
"Fever is frequently managed outside the purview of medical professionals, and antipyretic therapy, on the whole, is generally considered safe."2.41Toxicities of drugs used in the management of fever. ( Plaisance, KI, 2000)
" In summary, all methodologically sound studies available indicate that therapeutic dosing of paracetamol to the alcoholic patient is not associated with hepatic injury."2.41Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. ( Dart, RC; Kuffner, EK; Rumack, BH, 2000)
"Fever is an important symptom of underlying disease condition and in general is considered harmful in pediatric age group as it may lead to febrile seizures, stupor, dehydration increase work of breathing, discomfort and tachycardia."2.41Antipyretics in children. ( Bhatnagar, SK; Chandra, J, 2002)
"The decision to treat fever therefore needs to be: individualised, based on knowledge of effectiveness, balanced against any risk of harm that might result from intervening."2.41Management of the child with fever. ( Robertson, J, 2002)
"Acetaminophen is a safe antipyretic therapy prescribed in children."2.39[Paracetamol and other antipyretic analgesics: optimal doses in pediatrics]. ( Stamm, D, 1994)
"Reasons for treating fever include patient discomfort, the potential for adverse sequelae, the possibility of seizures, and the possibility that fever could affect the pharmacokinetic profiles of drugs."2.38Antipyretic therapy in the febrile child. ( Drwal-Klein, LA; Phelps, SJ, 1992)
"Acetaminophen is an effective antipyretic and analgesic with few side effects that is toxic only in massive overdose."2.36Use of antipyretic analgesics in the pediatric patient. ( Gladtke, E, 1983)
"Fever is one of the most common medical complaints referred to physicians for diagnosis and therapy."2.36Review of comparative antipyretic activity in children. ( Temple, AR, 1983)
"Aspirin has some advantage over acetaminophen for analgesia."2.36Aspirin and acetaminophen: a comparative view of their antipyretic and analgesic activity. ( Lovejoy, FH, 1978)
" Due to the strong evidence of increased risk of fever after administration, surveillance of adverse events following immunization (AEFIs) is a priority for 4CMenB."1.91Adverse events following immunization (AEFIs) with anti-meningococcus type B vaccine (4CMenB): Data of post-marketing active surveillance program. Apulia Region (Italy), 2019-2023. ( Ancona, D; Di Lorenzo, A; Martinelli, A; Moscara, L; Stefanizzi, P; Stella, P; Tafuri, S, 2023)
"Its therapeutic effect in treating fever and its safety have not been studied in animal models."1.72Investigations of the antipyretic effect and safety of Prasachandaeng, a traditional remedy from Thailand national list of essential medicines. ( Davies, NM; Inprasit, J; Itharat, A; Löbenberg, R; Ooraikul, B; Prommee, N; Somayaji, V; Sukkasem, K; Tasanarong, A; Thisayakorn, K, 2022)
" We aimed in this study to assess parents' knowledge, attitudes, and practice regarding paracetamol dosing and toxicity, as well as their awareness regarding paracetamol-containing products."1.62An assessment of parents' knowledge and awareness regarding paracetamol use in children: a cross-sectional study from Palestine. ( Al-Jabi, SW; Al-Tawil, F; Daifallah, A; Elkourdi, M; Jabr, R; Koni, A; Salman, Z; Samara, A; Zyoud, SH, 2021)
"Evaluate the appropriateness of acetaminophen dosing by caregivers seeking care for their children/wards at the emergency department of a pediatric hospital."1.62Appropriateness of Acetaminophen Dosing by Caregivers of Pediatric Patients Presenting to the Emergency Department at the University Pediatric Hospital in Puerto Rico. ( Hernández-Muñoz, JJ; Ortiz-Vera, YA; Parambil, A; Rodríguez-Rodríguez, NJ; Vélez-Rivera, SM, 2021)
"Acetaminophen was the most commonly used single agent (60,929/152,017, 40."1.62Comparative Analysis of Single and Combined Antipyretics Using Patient-Generated Health Data: Retrospective Observational Study. ( Ahn, SH; Chang, S; Kim, H; Kim, M; Lee, JH; Park, JA; Park, YR; Shin, JW, 2021)
"Fever has been reported as a common symptom occurring in COVID-19 illness."1.56The use of ibuprofen to treat fever in COVID-19: A possible indirect association with worse outcome? ( Haryadi, TH; Jamerson, BD, 2020)
"Among first-line methods to treat fever, ice packs were the most frequently utilized physical method (n=90, [47%]), external nonautomated system was the most frequent utilized device (n=49, [25%]), and paracetamol was the most frequently utilized drug (n=135, [70%])."1.51A Survey on Fever Monitoring and Management in Patients With Acute Brain Injury: The SUMMA Study. ( Helbok, R; Oddo, M; Picetti, E; Prisco, L; Taccone, FS, 2019)
" No protocol-related adverse events occurred."1.51Feasibility and Safety of Transnasal High Flow Air to Reduce Core Body Temperature in Febrile Neurocritical Care Patients: A Pilot Study. ( Assis, FR; Geocadin, RG; Shah, D; Tandri, H; Ziai, WC, 2019)
" Because of the limited clinical experience with the four-component meningococcal B vaccine (4CMenB), active surveillance for adverse events following immunization (AEFI) was conducted."1.48Short-term safety of 4CMenB vaccine during a mass meningococcal B vaccination campaign in Quebec, Canada. ( Billard, MN; Boulianne, N; De Serres, G; Deceuninck, G; Gagné, H; Gariépy, MC; Gilca, V; Landry, M; Ouakki, M; Rouleau, I; Skowronski, DM; Toth, E, 2018)
"Pediatric acute-liver-failure due to acetaminophen (APAP) administration at therapeutic dosage is rare, while viral infections and metabolic defects are the prevalent causes."1.46NBAS mutations cause acute liver failure: when acetaminophen is not a culprit. ( Brunati, A; Calvo, PL; Haak, TB; Olio, DD; Pinon, M; Romagnoli, R; Spada, M; Tandoi, F, 2017)
" Intravenous acetaminophen, with its increased bioavailability and more rapid onset of action, may have benefit in the intrapartum setting by reducing adverse neonatal and maternal outcomes associated with febrile morbidity."1.46Intravenous acetaminophen for the treatment of intrapartum fever and resolution of fetal tachycardia: a novel use for an old medication. ( Burgess, APH; Lakhi, N; Moretti, M; Ope-Adenuga, S; Reilly, JG, 2017)
"Ibuprofen use was significantly lower in children diagnosed with wheezing (n = 22, 52."1.46Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness. ( Elizur, A; Ganor, S; Kozer, E; Levine, H; Matok, I; Perlman, A, 2017)
"Acetaminophen was administered 2."1.46Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study. ( Moody, MA; Saleh, E; Swamy, GK; Walter, EB, 2017)
"Fever is a very common problem in pediatric age and is one of the most common reasons parents seek medical attention."1.46Parental beliefs and practices regarding childhood fever in Turkish primary care. ( Çakır, L; Cebeci, SE; Doğan, S; Gümüştakım, RŞ; Kırımlı, E; Yavuz, E; Yayla, E, 2017)
"The median reported threshold for treating fever in clinical practice was 38 °C (IQR 38-38."1.46Attitudes towards fever amongst UK paediatric intensive care staff. ( Agbeko, RS; Brick, T; Davies, P; Davis, PJ; Deep, A; Fortune, PM; Inwald, DP; Jones, A; Levin, R; Morris, KP; Pappachan, J; Peters, MJ; Ray, S; Tibby, SM; Tume, LN, 2017)
"Acetaminophen (APAP) elixir is a widely used pediatric antipyretic medication."1.43Are Recommended Doses of Acetaminophen Effective for Children Aged 2 to 3 Years? A Pharmacokinetic Modeling Answer. ( Abourbih, DA; Gosselin, S; Kazim, S; Villeneuve, E, 2016)
"Fever is frequently observed in conjunction with interleukin-2 (IL-2)-based immunotherapy."1.42Fever and the use of paracetamol during IL-2-based immunotherapy in metastatic melanoma. ( Bastholt, L; Christensen, IJ; Ellegaard, MB; Køstner, AH; Schmidt, H, 2015)
" This study aimed to assess the health literacy skills of parents and caregivers of preschool-aged children, using a progressive scenario describing a child with fever and presenting tasks relating to selection of a medicine and hypothetical dosing of their child."1.40Management of children's fever by parents and caregivers: Practical measurement of functional health literacy. ( Chaw, XY; Emmerton, L; Kairuz, T; Kelly, F; Marriott, J; Moles, R; Wheeler, A, 2014)
"Next day pyrexia was induced with lipopolysaccharide and paracetamol's (200 mg/kg, oral) antipyretic activity was assessed."1.40Arsenic reduces the antipyretic activity of paracetamol in rats: modulation of brain COX-2 activity and CB₁ receptor expression. ( Kannan, K; Kesavan, M; Sankar, P; Sarkar, SN; Suresh, S; Tandan, SK; Vijayakaran, K, 2014)
" No problems related to norepinephrine administration and/or increase in dosage were observed."1.40Intravenous paracetamol for fever control in acute brain injury patients: cerebral and hemodynamic effects. ( Antonini, MV; Caspani, ML; De Angelis, A; Picetti, E; Rossi, I; Servadei, F; Villani, F, 2014)
" Forty-six parents (32%) had an acetaminophen dosing error."1.39Parental language and dosing errors after discharge from the pediatric emergency department. ( Porter, SC; Samuels-Kalow, ME; Stack, AM, 2013)
"Although fever and hypothermia are common abnormal physical signs observed in patients admitted to intensive care units (ICU), little data exist on their optimal management."1.39Diagnosis and management of temperature abnormality in ICUs: a EUROBACT investigators' survey. ( de Waele, J; Dimopoulos, G; Koulenti, D; Laupland, KB; Niven, DJ; Rello, J; Tabah, A; Timsit, JF; Vesin, A, 2013)
"Fever is one of the most common problems about which primary caregivers seek medical advice for their children."1.38Knowledge of using acetaminophen syrup and comprehension of written medication instruction among caregivers with febrile children. ( Chang, MC; Chang, SC; Chen, YC; Smith, GD, 2012)
"Fever is one of the most commonly observed abnormal signs in patients with critical illness."1.38Assessment of the safety and feasibility of administering anti-pyretic therapy in critically ill adults: study protocol of a randomized trial. ( Kubes, P; Laupland, KB; Léger, C; Niven, DJ; Stelfox, HT, 2012)
"Dexketoprofen was the most effective antipyretic agent at the doses tested."1.38[Hemodynamic and antipyretic effects of paracetamol, metamizol and dexketoprofen in critical patients]. ( Betbesé, AJ; Gich, I; Mancebo, J; Vera, P; Zapata, L, 2012)
"In Denmark, the traditional choice for treating fever and pain in children is paracetamol."1.38[Ibuprofen is more effective than paracetamol in lowering the temperature in febrile children]. ( Lundstrøm, KE, 2012)
"Even though fever is a common symptom in childhood, it often worries parents and they may try to reduce discomfort by giving the child paracetamol, which is currently the most commonly sold over-the-counter medicine."1.38The majority of sick children receive paracetamol during the winter. ( Ertmann, RK; Møller, JJ; Reventlow, S; Siersma, V; Söderström, M; Waldorff, FB, 2012)
"We investigated acetaminophen use and identify factors contributing to supratherapeutic dosing of acetaminophen in hospitalized patients."1.38Supratherapeutic dosing of acetaminophen among hospitalized patients. ( Bates, DW; Boulware, LJ; Chang, F; Mahoney, LM; Maviglia, SM; Orav, EJ; Plasek, J; Rocha, RA; Zhou, L, 2012)
"Compared to conventional treatment, fever burden was significantly lower within the first 4 days after admission (p < 0."1.37Standardized antipyretic treatment in stroke: a pilot study. ( Beck, A; Breuer, L; Kallmünzer, B; Köhrmann, M; Kollmar, R; Krause, C; Pauli, E, 2011)
"Fever is an important mechanism of intrinsic resistance against infectious disease."1.37Fever and antipyresis in infection. ( Beasley, RW; Saxena, MK; Young, PJ, 2011)
"Danish parents regularly treat feverish children with paracetamol."1.36Paracetamol for feverish children: parental motives and experiences. ( Jensen, JF; Siersma, V; Söderström, M; Thorsen, H; Tønnesen, LL, 2010)
"Pallor was significantly more frequent after the first dose of whole cell pertussis than after acellulair pertussis vaccination (18."1.35Reactogenicity of infant whole cell pertussis combination vaccine compared with acellular pertussis vaccines with or without simultaneous pneumococcal vaccine in the Netherlands. ( David, S; van der Maas, NA; Vermeer-de Bondt, PE, 2008)
" Appropriate dosing and managing of these drugs do not likely lead to organ toxicity."1.35Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report. ( Angeli, S; Brugnara, M; Cuzzolin, L; Zaffanello, M, 2009)
"Twenty-one sequential case notes of Pfeiffer syndrome were retrospectively reviewed to collect 38 postoperative temperature courses."1.35Pyrexia after transcranial surgery for Pfeiffer syndrome. ( Anderson, PJ; David, DJ; Tamada, I, 2009)
"Acute renal failure is commonly seen in adults after treatment with analgesic agents."1.35Acute, reversible nonoliguric renal failure in two children associated with analgesic-antipyretic drugs. ( Baskin, E; Bayrakci, US; Cengiz, N; Erçoban, HS; Melek, E; Onay, OS, 2009)
"(1) Renal colic is an acute syndrome involving unilateral flank pain, linked to an obstruction in the upper urinary tract."1.35Renal colic in adults: NSAIDs and morphine are effective for pain relief. ( , 2009)
"Fever was most prominent in A/H3N2 and young children."1.34Natural course of fever during influenza virus infection in children. ( Ichihara, K; Johnson, AM; Suzuki, E, 2007)
"He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated."1.34Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007)
" There was a wide variability of the dosing interval."1.34Alternating antipyretics for fever reduction in children: an unfounded practice passed down to parents from pediatricians. ( Liebelt, EL; Wright, AD, 2007)
"Prazosin pretreatment eliminated the first T(c) rise but not the second; PGE(2) rose normally."1.34Preoptic norepinephrine mediates the febrile response of guinea pigs to lipopolysaccharide. ( Blatteis, CM; Feleder, C; Perlik, V, 2007)
"Conflicting attitudes toward febrile convulsions were highlighted by beliefs that antipyretic therapy prevents these and that antipyretics do not prevent initial febrile convulsions."1.33Fever management: paediatric nurses' knowledge, attitudes and influencing factors. ( Courtney, MD; Edwards, HE; Monaghan, SJ; Walsh, AM; Wilson, JE, 2005)
"To identify folk remedies used to treat fever, colic, and teething among black children in Detroit, Michigan."1.33The use of folk remedies among children in an urban black community: remedies for fever, colic, and teething. ( Janisse, J; Mathur, A; Smitherman, LC, 2005)
"In this clinically relevant septic shock model, the febrile response thus resulted in better respiratory function, lower blood lactate concentration, and prolonged survival time."1.33Fever control in septic shock: beneficial or harmful? ( Cai, Y; Nguyen, ND; Rogiers, P; Su, F; Vincent, JL; Wang, Z, 2005)
"Aspirin was used by 7."1.33Use and misuse of aspirin in rural Ethiopia. ( Aref-Adib, G; Britton, J; Davey, G; Duncan, P; Venn, A, 2006)
"To evaluate the risk of fulminant hepatic failure in relation to paracetamol overuse with therapeutic intent in febrile children."1.33Fulminant hepatic failure and paracetamol overuse with therapeutic intent in febrile children. ( Fernandopulle, BM; Fernandopulle, M; Lamabadusuriya, SP; Ranganathan, SS; Sathiadas, MG; Sumanasena, S, 2006)
"Fever was considered a definite sign of illness, almost congruent with the disease itself."1.32Childhood illnesses and the use of paracetamol (acetaminophen): a qualitative study of parents' management of common childhood illnesses. ( Helseth, S; Holager, T; Lagerløv, P, 2003)
"Febrile nonhemolytic transfusion reactions (FNHTRs) cause unwelcome interruptions during the course of blood product transfusions and necessitate measures to verify the nature of the reaction and to exclude certain dangerous reactions, such as hemolytic and septic phenomena."1.32Febrile nonhemolytic transfusion reactions. Management by premedication and cost implications in adult patients. ( Ezidiegwu, CN; Henry, JB; Kelly, KC; Lauenstein, KJ; Rosales, LG, 2004)
"To report a case of toxic epidermal necrolysis (TEN) associated with acetaminophen ingestion."1.31Toxic epidermal necrolysis associated with acetaminophen ingestion. ( Ben-Amitai, D; Garty, BZ; Halevi, A, 2000)
"Fever is a common symptom of childhood illness, and much time and effort is spent in the pursuit of reducing high temperature."1.31Physical treatment of fever. ( Purssell, E, 2000)
"Subjects from the six influenza A studies were challenged intranasally."1.31Effect of antipyretic therapy on the duration of illness in experimental influenza A, Shigella sonnei, and Rickettsia rickettsii infections. ( Kudaravalli, S; Levine, MM; Mackowiak, PA; Plaisance, KI; Wasserman, SS, 2000)
" We explore the toxicities of OTC cough and cold medications, discuss mechanisms of dosing errors, and suggest why physicians should be more vigilant in specifically inquiring about OTCs when evaluating an ill child."1.31Toxicity of over-the-counter cough and cold medications. ( Gunn, VL; Liebelt, EL; Serwint, JR; Taha, SH, 2001)
" Tablets "Paravit" have mark, which allows exact dosing for children of different age."1.30[The physiological properties of the action of a new analgesic and antipyretic preparation]. ( Chernykh, VP; Shapovalova, VO, 1997)
"To evaluate caregiver (parent or guardian) use of over-the-counter medications (OTCs) as related to the accuracy and correctness of dosing for children seen at a pediatric emergency department with nonemergent concerns."1.30Over-the-counter medications. Do parents give what they intend to give? ( Simon, HK; Weinkle, DA, 1997)
"A pharmacokinetic dynamic simulation model was used to predict rectal paracetamol dosing schedules which would maintain steady state plasma concentrations of 10-20 mg."1.30Rectal paracetamol dosing regimens: determination by computer simulation. ( Anderson, BJ; Holford, NH, 1997)
"Amphetamine treatment caused an acute rise in core body temperature to 40 degrees C for at least 1 hr and increased hsp25 and hsp70i levels, as measured by Western blotting, at 6, 24, 48, and 72 hr with no apparent induction of other hsps (hsp60, hsc70, or hsp90)."1.30Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein induction. ( Roberts, SM; Salminen, WF; Voellmy, R, 1997)
"Acetaminophen was the treatment of choice for 96% and dipyrone for 4%."1.30Parental knowledge of the treatment of fever in children. ( Barzilai, A; Davidovitch, N; Eisen, I; Kaplan, G; Linder, N; Sirota, L; Snapir, A, 1999)
"Sixty-nine children with first febrile seizures and no history of previous unprovoked seizures were matched for age (+/- 6 months), site of routine pediatric care, and date of visit (+/- 2 weeks) with 1 or 2 febrile controls who had no history of previous febrile or unprovoked seizures."1.29Risk factors for a first febrile seizure: a matched case-control study. ( Berg, AT; Crain, EF; Hauser, WA; Salomon, ME; Shapiro, ED; Shinnar, S, 1995)
"When post-ischemic seizures ensued in hyperglycemic subjects, temperature was 39."1.29Preischemic hyperglycemia leads to delayed postischemic hyperthermia. ( Lundgren, J; Siesjö, BK; Smith, ML; Uchino, H, 1994)
"For acetaminophen, the tlag was less than ibuprofen, Ka was more than ibuprofen, and beta was less than ibuprofen."1.28Single-dose pharmacokinetics of ibuprofen and acetaminophen in febrile children. ( Bertrand, KM; Brown, RD; Eichler, VF; Johnson, VA; Kearns, GL; Wilson, JT, 1992)
"Fever was induced by intraperitoneal injection of pyrogen (10 micrograms/kg)."1.28[Antipyretic action of aniline derivatives in rats during different parts of the day]. ( Rachtan, R; Starek, A, 1990)
"Cases of Reye's syndrome declined both in numbers (from a peak of 79 in 1983/4 to 19 in 1988/9) and in median age."1.28Trends in the incidence of Reye's syndrome and the use of aspirin. ( Banks, JH; Glasgow, JF; Hall, SM; Porter, JD; Robinson, PH, 1990)
"The reasons given for treating fever were to make the child comfortable (99%), to prevent seizures (63%), and to satisfy parents (44%)."1.27House officer management of the febrile child. A survey. ( Herskowitz, L; Weiss, J, 1983)
" Based on available clinical and pharmacokinetic data, acetaminophen should be dosed with single doses in the range of 10-15 mg/kg at 4-hour intervals."1.27Pediatric dosing of acetaminophen. ( Temple, AR, 1983)
"Acetaminophen is an effective analgesic and antipyretic agent with few adverse effects when used in recommended dosages."1.27Acetaminophen: a practical pharmacologic overview. ( Cornett, JW; Jackson, CH; MacDonald, NC, 1984)
"Fever is a part of the acute phase response, a generalized reaction to infection or inflammation initiated by interleukin-1 (IL-1)."1.27Fever. What to do and what not to do. ( Rosenthal, TC; Silverstein, DA, 1988)
" FS 205-397 will offer potent analgesic and antipyretic therapy in man based on an innovative biochemical principle which eliminates the undesirable toxic effects associated with most other non-narcotic analgesics."1.27FS 205-397: a new antipyretic analgesic with a paracetamol-like profile of activity but lack of acute hepatotoxicity in mice. ( Achini, R; Foote, RW; Römer, D, 1988)
"The parents of 106 children who had had Reye's syndrome and those of 185 comparison children who had febrile illnesses were interviewed in order to compare preadmission medication exposure rates in the two groups."1.27Preadmission antipyretics in Reye's syndrome. ( Glasgow, JF; Hall, SM; Hancock, P; Plaster, PA, 1988)
"Acetaminophen (15 mg/kg) was administered to each child and repeat temperatures were taken one and two hours later."1.27Childhood fever: correlation of diagnosis with temperature response to acetaminophen. ( Baker, MD; Carpenter, RO; Fosarelli, PD, 1987)
"The incidence of Reye syndrome has been decreasing in Michigan, perhaps as a result of decreased aspirin use among children."1.27Decreasing trends in Reye syndrome and aspirin use in Michigan, 1979 to 1984. ( Hall, WN; McGee, H; Monto, AS; Remington, PL; Rowley, D, 1986)
"Fever was measured with a thermometer in 114 ill children, 103 of whom had at least one measured temperature of 37."1.27Antipyretic use among children during the 1983 influenza season. ( Brandenburg, N; Glezen, WP; Gustafson, TL; Johnson, CC; Taylor, JP, 1985)
" Thus a pharmacokinetic interaction between CAP and APAP was not demonstrated in acutely ill febrile children during concomitant therapy."1.27Absence of a pharmacokinetic interaction between chloramphenicol and acetaminophen in children. ( Bocchini, JA; Brown, RD; Cotter, DL; Kearns, GL; Wilson, JT, 1985)
"Aspirin prescriptions were consistent over the entire study period among inpatients, but preadmission use decreased substantially."1.26Acetaminophen and aspirin. Prescription, use, and accidental ingestion among children. ( Lovejoy, FH; Mitchell, AA; Shapiro, S; Slone, D, 1982)
" Acetaminophen and diazepam seemed to be well absorbed from the rectal suppositories, the maximal plasma concentration of diazepam after a rectal dose of 0."1.26Antipyretic effect and plasma concentrations of rectal acetaminophen and diazepam in children. ( Kangas, L; Keinänen-Kiukaanniemi, S; Luoma, P; Saukkonen, AL; Similä, S, 1979)
" With the same dosage serum concentrations are lower after rectal application than after oral."1.26[Investigations concerning temperature and serum concentrations of paracetamol in febrile infants following rectal application of paracetamol (author's transl)]. ( Windofer, A, 1978)
" The children were divided into 3 groups on the basis of dosage (5, 10 and 20 mg/kg body weight)."1.26[Investigations concerning serum concentration and temperature following oral application of a new paracetamol preparation (author's transl)]. ( Vogel, C; Windorfer, A, 1976)
"Short-term fever is usually a viral infection but may be a bacterial infection."1.26Fever in childhood. ( Shrand, H, 1976)
"Marked cyanosis was observed in experimental cats within 4 hours after administration of one 325-mg tablet."1.25Acetaminophen toxicosis in the cat. ( Duncan, JR; Finco, DC; Prasse, KW; Schall, WD, 1975)
"Indomethacin was more potent than paracetamol and both were more potent than injected I."1.25Prostaglandins, endotoxin and lipid A on body temperature in rats. ( Feldberg, W; Saxena, PN, 1975)
"Fever was produced by injection of the bacterial pyrogen of Shigella dysenteriae either into the third ventricle, cisterna magna or I."1.25Effect of pyrogen and antipyretics on prostaglandin acitvity in cisternal c.s.f. of unanaesthetized cats. ( Feldberg, W; Gupta, KP; Milton, AS; Wendlandt, S, 1973)
"The characteristics, circumstances, and treatment of 450 pyrexial reactions occurring in 468 patient-months over a period of two and a half years, using a warm single-pass Kiil system, were studied."1.25Pyrexial reactions during haemodialysis. ( Robinson, PJ; Rosen, SM, 1971)

Research

Studies (704)

TimeframeStudies, this research(%)All Research%
pre-1990132 (18.75)18.7374
1990's117 (16.62)18.2507
2000's199 (28.27)29.6817
2010's204 (28.98)24.3611
2020's52 (7.39)2.80

Authors

AuthorsStudies
Friesen, RW1
Mancini, JA1
Eissa, AA1
Farag, NA1
Soliman, GA1
Tripathi, P1
Tripathi, AC1
Chawla, V1
Saraf, SK1
Das, M1
Bhattacharjee, S1
Fronczek, FR1
Bazan, NG1
Trudell, ML1
Gautry, P1
Bussereau, M2
D'Eramo, RE1
Nadpara, PA1
Sandler, M1
Taylor, PD1
Brophy, GM1
Saifuddin, A1
Koesnoe, S1
Kurniati, N1
Sirait, S1
Arisanty, R1
Yunihastuti, E1
Kokawa, T1
Yamamoto, H1
Itoh, M1
Shimane, A1
Kawai, H1
Takaya, T1
Kazama, I1
Senzaki, M1
Lee, E3
Song, YJ1
Jeon, S1
Lee, J2
Lee, JY1
Han, MK1
Jeong, HG1
Prommee, N1
Itharat, A1
Thisayakorn, K1
Sukkasem, K1
Inprasit, J1
Tasanarong, A1
Löbenberg, R1
Somayaji, V1
Davies, NM1
Ooraikul, B1
Yin, F1
Liu, Y1
Guo, H1
Tan, E2
Hoare, K1
Riley, J1
Fernando, K1
Haskell, L1
McKinlay, CJ1
Dalziel, SR2
Braithwaite, I2
Tanaka, M1
Wang, Q1
Morikawa, Y1
Tsukamoto, J1
Sammori, H1
Takehira, K1
Yano, M1
Miyama, S1
Fujita, S1
Narita, K1
Kishibe, S1
Morikawa, EK1
Suzuki, S1
Hataya, H1
Tantivit, N1
Thangjui, S1
Trongtorsak, A1
Al-Antary, ET1
Ramiz, S1
Simon Junior, H1
Pedreira, MC1
Barbosa, SMM1
Fernandes, TF1
Escobar, AMU1
Chulapornsiri, C2
Pradermdussadeeporn, E1
Pongpittayut, S1
Sutthithumthaworn, A1
Aninlabon, W1
Wisassittichok, M1
Maitongngam, K1
Subchartanan, J1
Suteerojntrakool, O1
Tempark, T1
Bongsebandhu-Phubhakdi, C1
Chilombe, MB1
McDermott, MP1
Seydel, KB1
Mathews, M1
Mwenechanya, M1
Birbeck, GL1
Goodarzi, H1
Valizadeh, F1
Ghasemi, F1
Ebrahimzade, F1
Seifosadat, SH1
Delfan, B1
Taee, N1
Ye, K3
Li, Y3
Xing, Y3
Liu, K3
Zhou, F3
Tian, Y3
Zhang, Y3
Baker, AH2
Monuteaux, MC2
Michelson, KA2
Neuman, MI2
Bello, AM1
Dye, C1
Zempsky, W1
Bell, J1
Mossali, VM1
Kachroo, P1
Siddiqui, K1
Roy, R1
Roy, J1
Liya, IJ1
Basher, MA1
Miah, MY1
Verd, S1
Rodríguez-Trabal, C1
Mambié, M1
Milani, GP3
Corsello, A1
Schulz, PJ1
Fadda, M1
Giannì, ML1
Alberti, I1
Comotti, A1
Marchisio, P1
Chiappini, E4
Peroni, D1
Zhou, P1
Chen, L1
Wang, E1
He, L1
Tian, S1
Zhai, S1
de Sévaux, JLH1
Damoiseaux, RA2
van de Pol, AC2
Lutje, V1
Hay, AD6
Little, P2
Schilder, AG2
Venekamp, RP2
Franceschi, F1
Saviano, A1
Carnicelli, A1
Lorusso, C1
Novelli, A1
Candelli, M1
Ojetti, V1
Covino, M1
Abitbol, V1
Sohn, WY1
Horn, M1
Safadi, MAP1
Stefanizzi, P1
Di Lorenzo, A1
Martinelli, A1
Moscara, L1
Stella, P1
Ancona, D1
Tafuri, S1
Moffett, BS1
Gutierrez, K1
Davis, K1
Sigdel, B1
Strobel, N1
Girard, P1
Cantet, C1
Rolland, Y1
Young, PJ5
Bailey, MJ1
Bass, F1
Beasley, RW4
Freebairn, RC3
Hammond, NE5
van Haren, FMP1
Harward, ML1
Henderson, SJ3
Mackle, DM1
McArthur, CJ3
McGuinness, SP3
Myburgh, JA4
Saxena, MK7
Turner, AM1
Webb, SAR1
Bellomo, R6
Margan Koletic, Z1
Dosenovic, S1
Puljak, L1
Dubus, M1
Ladhani, S1
Vasu, V1
Hervella, P1
Rodríguez-Yáñez, M1
Pumar, JM1
Ávila-Gómez, P1
da Silva-Candal, A1
López-Loureiro, I1
Rodríguez-Maqueda, E1
Correa-Paz, C1
Castillo, J1
Sobrino, T1
Campos, F1
Iglesias-Rey, R1
Veteikis, D1
Elgamasy, S1
Kamel, MG1
Ghozy, S1
Khalil, A1
Morra, ME1
Islam, SMS1
Della-Torre, E1
Della-Torre, F1
Kusanovic, M1
Scotti, R1
Ramirez, GA1
Dagna, L1
Tresoldi, M1
Jamerson, BD1
Haryadi, TH1
Rinott, E1
Kozer, E6
Shapira, Y1
Bar-Haim, A1
Youngster, I1
Badjatia, N2
Gupta, N1
Sanchez, S1
Haymore, J1
Tripathi, H1
Shah, R1
Hannan, C1
Tandri, H2
Liu, JB1
Hao, D1
McKinlay, CJD1
Alaje, EO1
Udoh, EE1
Akande, PA1
Odey, FA1
Meremikwu, MM1
Mehraban, S1
Nematian, S1
Mehraban, SS1
Petrucci, S1
Tricorico, G1
Parnas, Z1
Shats, L1
Kanninen, T1
Moretti, M2
Cabbad, M1
Lakhi, N2
Rosenberg, K1
Daifallah, A1
Jabr, R1
Al-Tawil, F1
Elkourdi, M1
Salman, Z1
Koni, A1
Samara, A1
Al-Jabi, SW1
Zyoud, SH1
Okereke, B1
Ibeleme, O1
Bisi-Onyemaechi, A1
Can, Ö1
Kıyan, GS1
Yalçınlı, S1
Vélez-Rivera, SM1
Rodríguez-Rodríguez, NJ1
Ortiz-Vera, YA1
Parambil, A1
Hernández-Muñoz, JJ1
Long, B1
Gottlieb, M1
Paul, IM3
Walson, PD7
Kloeden, B1
Tham, D1
Oakley, E1
Cheek, J1
Park, YR1
Kim, H1
Park, JA1
Ahn, SH1
Chang, S1
Shin, JW1
Kim, M1
Lee, JH3
Young, TL1
King, H1
Deshpande, S1
Woodbridge, T1
Hilliard, T1
Standing, J1
Lewis, M1
Ward, L1
Finn, A1
Roderick, M1
Bloukh, S1
Wazaify, M1
Matheson, C1
Schell-Chaple, HM1
Liu, KD1
Matthay, MA1
Sessler, DI1
Puntillo, KA1
Eizenga, WE1
Opstelten, W1
Simon, A1
Leffler, A1
Hoag, SD1
Chung, K1
Ray, S3
Brick, T2
Raman, S1
Birrell, PJ1
Klein, NJ1
Peters, MJ3
Narayan, K1
Cooper, S1
Morphet, J1
Innes, K1
Sil, A1
Ravi, MD1
Patnaik, BN1
Dhingra, MS1
Dupuy, M1
Gandhi, DJ1
Dhaded, SM1
Dubey, AP1
Kundu, R1
Lalwani, SK1
Chhatwal, J1
Mathew, LG1
Gupta, M1
Sharma, SD1
Bavdekar, SB1
Rout, SP1
Jayanth, MV1
D'Cor, NA1
Mangarule, SA1
Ravinuthala, S1
Reddy E, J1
Jackson, C1
Yarwood, J1
Saliba, V2
Bedford, H1
Luo, S1
Ran, M1
Luo, Q1
Shu, M1
Guo, Q1
Zhu, Y1
Xie, X1
Zhang, C1
Wan, C1
Khan, MS1
Hamid, A1
Akram, M2
Mustafa, SB1
Sami, A1
Shah, SMA2
Usmanghani, K1
Lee, HJ1
Suh, YJ2
Kim, AJ2
Han, SB1
Durey, A2
Roy, S1
Simalti, AK1
Ocan, M1
Aono, M1
Bukirwa, C1
Luyinda, E1
Ochwo, C1
Nsambu, E1
Namugonza, S1
Makoba, J1
Kandaruku, E1
Muyende, H1
Nakawunde, A1
Calvo, PL1
Tandoi, F1
Haak, TB1
Brunati, A1
Pinon, M1
Olio, DD1
Romagnoli, R1
Spada, M1
Rakowsky, S1
Spiller, HA1
Casavant, MJ1
Chounthirath, T1
Hodges, NL1
Kim, EH1
Smith, GA1
Walter, EB2
Hornik, CP1
Grohskopf, L1
McGee, CE1
Todd, CA1
Museru, OI1
Harrington, L1
Broder, KR1
Kang, S1
Rogers, L1
Brown, KL1
Saeedan, AS1
Singh, I1
Ansari, MN1
Singh, M1
Rawat, JK1
Devi, U1
Gautam, S1
Yadav, RK1
Kaithwas, G1
Safari, L1
Patrick, JD1
Ope-Adenuga, S1
Burgess, APH1
Reilly, JG1
Parker, SL1
Saxena, M4
Gowardman, J2
Lipman, J2
Myburgh, J4
Roberts, JA2
Choi, SJ1
Moon, S1
Choi, UY1
Chun, YH1
Rhim, JW1
Kim, HM1
Jeong, DC1
Heinzl, S1
Pigazzani, F1
Mackenzie, I1
MacDonald, TM1
Picetti, E2
Oddo, M1
Prisco, L1
Helbok, R1
Taccone, FS1
Saeki, S1
De Serres, G1
Billard, MN1
Gariépy, MC1
Rouleau, I1
Toth, E1
Landry, M1
Boulianne, N1
Gagné, H1
Gilca, V1
Deceuninck, G1
Ouakki, M1
Skowronski, DM1
Islam, MT1
Wang, MH1
Hu, A1
Lee, YS2
Lai, CC1
Ziai, WC1
Shah, D2
Assis, FR1
Geocadin, RG1
Deen, J1
von Seidlein, L1
Vasikasin, V1
Rojdumrongrattana, T1
Chuerboonchai, W1
Siriwiwattana, T1
Thongtaeparak, W1
Niyasom, S1
Lertliewtrakool, N1
Jitsiri, S1
Changpradub, D1
Seifert, G1
Brandes-Schramm, J1
Zimmermann, A1
Lehmacher, W1
Kamin, W1
Ajaz, M1
Asif, HM1
Hussain, A1
Tahir, IM1
Daniyal, M1
Khan, FS1
Gustavson, K1
Ask, H1
Ystrom, E1
Stoltenberg, C1
Lipkin, WI1
Surén, P1
Håberg, SE1
Magnus, P1
Knudsen, GP1
Eilertsen, E1
Bresnahan, M1
Aase, H1
Mjaaland, S1
Susser, ES1
Hornig, M1
Reichborn-Kjennerud, T1
Kose, D1
Cadirci, E1
Halici, Z1
Sirin, B1
Dincer, B1
Ettinger, WH1
Frank, B1
Fulton, RL1
Weimar, C1
Lees, KR1
Sanders, RD1
Malya, RR1
Engström Ruud, L1
Wilhelms, DB1
Eskilsson, A1
Vasilache, AM1
Elander, L1
Engblom, D1
Blomqvist, A1
Mangold, KA1
Reynolds, SL1
de Ridder, IR3
de Jong, FJ1
den Hertog, HM6
Lingsma, HF1
van Gemert, HM12
Schreuder, AH3
Ruitenberg, A3
Maasland, EL3
Saxena, R3
Oomes, P1
van Tuijl, J1
Koudstaal, PJ10
Kappelle, LJ8
Algra, A6
van der Worp, HB12
Dippel, DW13
Charpiat, B1
Zhou, L2
Maviglia, SM2
Rocha, RA2
Weinkove, R1
Clay, J1
Wood, C1
King, D1
Emmerton, L1
Chaw, XY1
Kelly, F1
Kairuz, T1
Marriott, J1
Wheeler, A1
Moles, R1
Morrison, CL1
Glenn, LL1
Taylor, CB1
Seppelt, IM1
Glass, P1
Temple, AR5
Temple, BR1
Kuffner, EK3
Samuels-Kalow, ME1
Stack, AM1
Porter, SC1
Lavesson, T2
Källén, K2
Olofsson, P2
Wong, T3
Stang, AS3
Ganshorn, H3
Hartling, L3
Maconochie, IK3
Thomsen, AM3
Johnson, DW3
Dvorkin, R1
Bair, J1
Patel, H3
Glantz, S1
Yens, DP1
Rosalia, A1
Marguilies, J1
Drury, P1
Levi, C1
McInnes, E1
Hardy, J1
Ward, J1
Grimshaw, JM1
D' Este, C1
Dale, S2
McElduff, P1
Cheung, NW1
Quinn, C1
Griffiths, R1
Evans, M1
Cadilhac, D1
Middleton, S1
Weatherall, M3
Haren, FM1
Mackle, D3
Webb, SA2
Niven, DJ3
Laupland, KB3
Tabah, A1
Vesin, A1
Rello, J1
Koulenti, D1
Dimopoulos, G1
de Waele, J1
Timsit, JF1
D'Elios, S1
Mazzantini, R1
Becherucci, P3
Pierattelli, M1
Galli, L3
de Martino, M3
Marzuillo, P1
Guarino, S1
Barbi, E1
de Bont, EG1
Brand, PL1
Dinant, GJ1
van Well, GT1
Cals, J1
Vijayakaran, K1
Kannan, K1
Kesavan, M1
Suresh, S1
Sankar, P1
Tandan, SK1
Sarkar, SN1
Giamarellos-Bourboulis, EJ2
Spyridaki, A1
Savva, A1
Georgitsi, M1
Tsaganos, T2
Mouktaroudi, M1
Raftogiannis, M1
Antonopoulou, A1
Papaziogas, V1
Baziaka, F1
Sereti, K1
Christopoulos, P1
Marioli, A1
Kanni, T1
Maravitsa, P1
Pantelidou, I1
Leventogiannis, K1
Tsiaoussis, P1
Lymberopoulou, K1
Koutelidakis, IM1
Pauchard, JY1
Gehri, M2
Biswal, S1
Sahoo, SS1
Luyasu, S1
Wamelink, MM1
Galanti, L1
Dive, A1
Ahmadimanesh, M1
Shadnia, S1
Ghazi-Khansari, M1
Duran, J1
Siddique, S1
Cleary, M1
De Angelis, A1
Villani, F1
Antonini, MV1
Rossi, I1
Servadei, F1
Caspani, ML1
Doedée, AM1
Boland, GJ1
Pennings, JL1
de Klerk, A1
Berbers, GA1
van der Klis, FR1
de Melker, HE1
van Loveren, H1
Janssen, R1
Kanabar, D2
Nazarko, L1
Lee, CI1
Menzies, AM1
Haydu, LE1
Azer, M1
Clements, A1
Kefford, RF1
Long, GV1
Quartuccio, L1
Maset, M1
Soardo, G1
Avellini, C1
De Vita, S1
Køstner, AH1
Ellegaard, MB1
Christensen, IJ1
Bastholt, L1
Schmidt, H1
Mayooran, N1
O'Cathain, E1
Bresnihan, MN1
Patil, N1
Knox, C1
Selker, E1
Ito, T1
Watanabe, S1
Tsuruga, K1
Aizawa, T1
Hirono, K1
Ito, E1
Joh, K1
Tanaka, H1
Shastri, N1
Chatterjee, T1
Bhattacharyya, S1
Yeh, KT1
Wu, WT1
Subeq, YM1
Niu, CC1
Liao, KW1
Chen, IH1
Wang, JH1
Lee, RP1
Young, P4
Freebairn, R1
Hammond, N1
van Haren, F1
Holliday, M1
Henderson, S1
McArthur, C1
McGuinness, S1
Webb, S1
Beasley, R5
Braccio, S1
Ramsay, M1
Ladhani, SN1
Findlow, J1
Taylor, C2
Billot, L1
Bompoint, S1
Abourbih, DA1
Gosselin, S1
Villeneuve, E1
Kazim, S1
Lubrano, R1
Paoli, S1
Bonci, M1
Di Ruzza, L1
Cecchetti, C1
Falsaperla, R1
Pavone, P1
Matin, N1
Vitaliti, G1
Gentile, I1
Patel, J2
Arik, G1
Şengül Ayçiçek, G1
Ulger, Z1
Leiner, S1
Bae, JI1
Ahn, S1
Kim, WY1
Oh, BJ1
Lim, KS1
Bertille, N1
Fournier-Charrière, E1
Pons, G3
Khoshnood, B1
Chalumeau, M1
Moriarty, C1
Carroll, W1
Mısırlıoğlu, ED1
Akman, AÖ1
Vezir, E1
Başaran, Ö1
Çakar, N1
Kocabaş, CN1
Zhang, XC1
Siket, M1
Binder, W1
Sheehan, WJ2
Mauger, DT1
Moy, JN1
Boehmer, SJ1
Szefler, SJ1
Fitzpatrick, AM1
Jackson, DJ1
Bacharier, LB1
Cabana, MD1
Covar, R1
Holguin, F1
Lemanske, RF1
Martinez, FD1
Pongracic, JA1
Beigelman, A1
Baxi, SN1
Benson, M1
Blake, K1
Chmiel, JF1
Daines, CL1
Daines, MO1
Gaffin, JM1
Gentile, DA1
Gower, WA1
Israel, E1
Kumar, HV1
Lang, JE1
Lazarus, SC1
Lima, JJ1
Ly, N1
Marbin, J1
Morgan, WJ1
Myers, RE1
Olin, JT1
Peters, SP1
Raissy, HH1
Robison, RG1
Ross, K1
Sorkness, CA1
Thyne, SM1
Wechsler, ME1
Phipatanakul, W2
Mayor, S1
Falup-Pecurariu, O1
Man, SC1
Neamtu, ML1
Chicin, G1
Baciu, G1
Pitic, C1
Cara, AC1
Neculau, AE1
Burlea, M1
Brinza, IL1
Schnell, CN1
Sas, V1
Lupu, VV1
François, N1
Swinnen, K1
Borys, D2
Lava, SA2
Santi, M1
Bianchetti, MG2
Simonetti, GD2
Tseti, IK1
Tziolos, N1
Soumelas, GS1
Koupetori, M1
Pyrpasopoulou, A1
Akinosoglou, K1
Gogos, C1
Tsokos, N1
Karagiannis, A1
Sympardi, S1
Matok, I1
Elizur, A1
Perlman, A1
Ganor, S1
Levine, H1
Saleh, E1
Swamy, GK1
Moody, MA1
Jayawardena, S1
Kellstein, D1
Yavuz, E1
Yayla, E1
Cebeci, SE1
Kırımlı, E1
Gümüştakım, RŞ1
Çakır, L1
Doğan, S1
Uzoigwe, CE1
Ali, OH1
Sjoukes, A1
Chiumello, D1
Gotti, M1
Vergani, G1
Kanabar, DJ1
Agbeko, RS1
Davies, P2
Davis, PJ1
Deep, A1
Fortune, PM1
Inwald, DP1
Jones, A1
Levin, R1
Morris, KP1
Pappachan, J1
Tibby, SM1
Tume, LN1
Khalil, SN1
Hahn, BJ1
Chumpitazi, CE1
Rock, AD1
Kaelin, BA1
Macias, CG1
Helbling, R1
Conficconi, E1
Wyttenbach, M1
Benetti, C1
Hamitaga, F1
Fossali, EF1
Wysocki, J1
Center, KJ1
Brzostek, J1
Majda-Stanislawska, E1
Szymanski, H1
Szenborn, L1
Czajka, H1
Hasiec, B1
Dziduch, J1
Jackowska, T1
Witor, A1
Kopińska, E1
Konior, R1
Giardina, PC1
Sundaraiyer, V1
Patterson, S1
Gruber, WC1
Scott, DA1
Gurtman, A1
van Tuijl, JH1
Jansen, BP1
Van den Berg-Vos, RM1
Vermeij, F1
Solzbach, U1
Knöpfle, N1
Haas, H1
Kramer, LC1
Richards, PA1
Thompson, AM1
Harper, DP1
Fairchok, MP1
Yalçin, SS1
Gümüş, A1
Yurdakök, K1
Kennedy, LD1
Case, LD1
Hurd, DD1
Cruz, JM1
Pomper, GJ1
Costelloe, C3
Redmond, NM2
Montgomery, AA2
Fletcher, M4
Hollinghurst, S3
Peters, TJ3
Harnden, A1
David, S1
Vermeer-de Bondt, PE1
van der Maas, NA1
Redmond, N2
Montgomery, A1
Purssell, E5
Clayton, T1
Crane, J1
von Mutius, E1
Lai, CK1
Montefort, S1
Stewart, A1
Ospina, CA1
Salcedo, A1
Hersch, M1
Raveh, D1
Izbicki, G1
Moore, ND1
Goldstein, LH1
Berlin, M1
Berkovitch, M3
van Gijn, J5
Tobian, AA1
King, KE1
Ness, PM1
Warwick, C1
Guo, SX1
Cheng, Y1
Glatstein, M1
Scolnik, D5
Yam, MF1
Ang, LF1
Basir, R1
Salman, IM1
Ameer, OZ1
Asmawi, MZ1
Celebi, S1
Hacimustafaoglu, M1
Aygun, D1
Arisoy, ES1
Karali, Y1
Akgoz, S1
Citak Kurt, AN1
Seringec, M1
Licht-Strunk, E1
Koch, W1
Zaffanello, M1
Brugnara, M1
Angeli, S1
Cuzzolin, L1
Duggan, ST1
Scott, LJ1
Tamada, I1
David, DJ1
Anderson, PJ1
Kanashiro, A1
Pessini, AC1
Machado, RR1
Malvar, Ddo C1
Aguiar, FA1
Soares, DM1
do Vale, ML1
de Souza, GE1
Chua, YA1
Nurhaslina, H1
Gan, SH1
Onay, OS1
Erçoban, HS1
Bayrakci, US1
Melek, E1
Cengiz, N1
Baskin, E1
Cohee, LM1
Crocetti, MT1
Serwint, JR3
Sabath, B1
Kapoor, S1
Southey, ER1
Soares-Weiser, K1
Kleijnen, J2
Niazi, J1
Singh, P1
Bansal, Y1
Goel, RK1
Kedzia, A1
Bołdys, A1
Krysiak, R1
Szkróbka, W1
Okopień, B1
Greenberg, RS1
Chen, H1
Hasday, JD1
Nabulsi, M2
Principi, N2
Longhi, R2
Tovo, PA2
Bonsignori, F2
Esposito, S3
Festini, F2
Lucchesi, B2
Mugelli, A2
Chen, RT1
Clark, TA1
Halperin, SA1
Prymula, R1
Siegrist, CA1
Chlibek, R1
Zemlickova, H1
Vackova, M1
Smetana, J1
Lommel, P1
Kaliskova, E1
Schuerman, L1
Good, P1
Fowler, AW1
Bareiss, D1
Semela, D1
Heim, M1
Terracciano, L1
Hunziker, S1
Siddiqi, A1
Morkel, JA1
Zafar, S1
Tapiainen, T1
Dunder, T1
Möttönen, M1
Pokka, T1
Uhari, M2
Amabeoku, GJ1
Erasmus, SJ1
Ojewole, JA1
Mukinda, JT1
Pierce, CA1
Voss, B1
Kokki, H2
Kokki, M2
Crook, J1
Jensen, JF1
Tønnesen, LL1
Söderström, M2
Thorsen, H1
Siersma, V2
Miller, RJ1
Bailey, J1
Sullivan, K1
Martí-Carvajal, AJ1
Solà, I1
González, LE1
Leon de Gonzalez, G1
Rodriguez-Malagon, N1
Schultz, ST1
Boyle, M1
Nicholson, L1
O'Brien, M1
Flynn, GM1
Collins, DW1
Walsh, WR1
Bihari, D1
Allan, GM1
Ivers, N1
Shevchuk, Y1
Schnabel, E1
Heinrich, J1
Thompson, HJ1
Kagan, SH1
Jahr, JS1
Lee, VK1
Dixson, M1
Silverman, SL1
Kriegman, A1
Goncalves, J1
Kianifard, F1
Carlson, T1
Leary, E1
Candiotti, KA1
Bergese, SD1
Viscusi, ER1
Singla, SK1
Royal, MA3
Singla, NK1
Trainor, JL1
Stamos, JK1
Hopchet, L1
Kulo, A1
Rayyan, M1
Verbesselt, R1
Vanhole, C1
de Hoon, JN1
Allegaert, K1
Kallmünzer, B1
Krause, C1
Pauli, E1
Beck, A1
Breuer, L1
Köhrmann, M1
Kollmar, R1
Meisel, A1
Andabaka, T1
Globočnik, T1
Vukelić, D1
Baršić, B1
Wark, JD1
Bensen, W1
Recknor, C1
Ryabitseva, O1
Chiodo, J1
Mesenbrink, P1
de Villiers, TJ1
Sturgis, SA1
Yang, C1
Engle, L1
Watts, H1
Berlin, CM1
Peacock, WF1
Breitmeyer, JB2
Pan, C1
Smith, WB1
Mullins, ME1
Empey, M1
Jaramillo, D1
Sosa, S1
Human, T1
Diringer, MN1
Ochi, H1
Wada, K1
Okada, H1
Kohara, N1
Fujita, T1
Toda, K1
Sakamoto, M1
Seguchi, O1
Murata, Y1
Yanase, M1
Nakatani, T1
Kett, DH1
Ang, R1
Chang, MC1
Chen, YC1
Chang, SC1
Smith, GD1
Ziemann-Gimmel, P1
Eastwood, GM1
Kofoed, PE1
Ursing, J1
Rodrigues, A1
Rombo, L1
Salichs, M1
Sabaté, D1
Ciervo, O1
Homedes, J1
Jackson, LA1
Peterson, D1
Dunn, J1
Hambidge, SJ1
Dunstan, M1
Starkovich, P1
Yu, O1
Benoit, J1
Dominguez-Islas, CP1
Carste, B1
Benson, P1
Nelson, JC1
Senel, S1
Erkek, N1
Karacan, CD1
Maesschalck, PJ1
Oziegbe, EO1
Esan, TA1
Adekoya-Sofowora, CA1
Folayan, MO1
Lanas, A1
McCarthy, D1
Voelker, M2
Brueckner, A1
Senn, S1
Baron, JA1
Pickens, LA1
Meinke, SM1
Mohr, NM1
Fuller, BM1
Skrupky, LP1
Moy, H2
Alunday, R2
Micek, ST1
Fagley, RE1
Eyers, S1
Jefferies, S1
Shirtcliffe, P1
Perrin, K1
Wrotek, SE1
Kozak, WE1
Hess, DC1
Fagan, SC1
Dhingra, B1
Mishra, D1
Reade, MC1
Léger, C2
Kubes, P2
Stelfox, HT2
Vera, P1
Zapata, L1
Gich, I1
Mancebo, J1
Betbesé, AJ1
Mpharm, TB1
Kumar, CT1
Egi, M1
Argentieri, J1
Morrone, K1
Pollack, Y1
Hoover, L1
McCarthy, DM1
Thirstrup, S1
Lundstrøm, KE1
Muhammad, N1
Saeed, M1
Khan, H1
Smith, C1
Goldman, RD4
Venturini, E1
Mirmoghtadaee, P1
Sabzghabaee, AM1
Bagheri, M1
Soltani, R1
Obu, HA1
Chinawa, JM1
Ubesie, AC1
Eke, CB1
Ndu, IK1
George, M1
Phelps, MA1
Kitzmiller, JP1
Pereira, GL1
Dagostini, JM1
Pizzol, Tda S1
Mohr, N1
Skrupky, L1
Fuller, B1
Wallendorf, M1
Micek, S1
Fagley, R1
van den Anker, JN1
van Haren, FM1
Oberoi, S1
Trehan, A1
Marwaha, RK1
Bansal, D1
Ertmann, RK1
Møller, JJ1
Waldorff, FB1
Reventlow, S1
Bardage, C1
Westerlund, T1
Barzi, S1
Bernsten, C1
Ghosh, S1
Pandya, N1
Naik, S1
Åkerman, F1
Mahoney, LM1
Chang, F1
Orav, EJ1
Plasek, J1
Boulware, LJ1
Bates, DW1
Nolent, P1
Jacobson, S1
Diamond, S1
Young, NL1
Takagi, K1
Goetzl, L2
Evans, T2
Rivers, J2
Suresh, MS2
Lieberman, E2
Cruz, P1
Garutti, I1
Díaz, S1
Fernández-Quero, L1
Locham, KK1
Sodhi, M1
Jindal, G1
Mason, S1
Thorp, S1
Burke, D1
Oborilová, A1
Mayer, J1
Pospísil, Z1
Korístek, Z1
Chattopadhyay, D1
Arunachalam, G1
Mandal, AB1
Mandal, SC3
Rao, RB1
Anupama, K1
Swaroop, KR1
Murugesan, T1
Pal, M1
Watts, R1
Robertson, J2
Thomas, G1
Amdekar, YK2
Khubchandani, RP2
van Breda, EJ6
Meijer, RJ2
Lesko, SM6
Devi, BP1
Boominathan, R1
Meremikwu, M2
Oyo-Ita, A2
Moore, PK1
Marshall, M1
Russell, FM1
Shann, F2
Curtis, N1
Mulholland, K1
Giles, FJ1
Cortes, JE1
Halliburton, TA1
Mallard, SJ1
Estey, EH1
Waddelow, TA1
Lim, JT1
GARCIAHERRERA, E1
Havinga, W1
Lagerløv, P4
Helseth, S1
Holager, T3
Sulter, G1
Elting, JW1
Maurits, N1
Luijckx, GJ1
Luyckx, GJ1
De Keyser, J1
Gozzoli, V1
Treggiari, MM1
Kleger, GR1
Roux-Lombard, P1
Fathi, M1
Pichard, C2
Romand, JA2
Huang, WT1
Wang, JJ1
Lin, MT1
Ko, K1
Linett, LJ1
Wahba, H1
Geffroy, A1
Bronchard, R1
Merckx, P1
Seince, PF1
Faillot, T1
Albaladejo, P1
Marty, J1
Losek, JD1
Citron, DR1
Richardson, BE1
Perrott, DA1
Piira, T1
Goodenough, B1
Champion, GD1
Westergren, T2
Aamodt, G2
Río, J3
Nos, C1
Bonaventura, I1
Arroyo, R1
Genis, D1
Sureda, B1
Ara, JR1
Brieva, L1
Martín, J1
Saiz, A1
Sánchez López, F1
Prieto, JM1
Roquer, J1
Dorado, JF1
Montalban, X3
Ezidiegwu, CN1
Lauenstein, KJ1
Rosales, LG1
Kelly, KC1
Henry, JB1
Mennick, F1
Richardson, J1
Sills, J1
Carabaño Aguado, I1
Jiménez López, I1
López-Cerón Pinilla, M1
Calvo García, I1
Pello Lázaro, AM1
Balugo Bengoechea, P1
Baro Fernández, M1
Ruiz Contreras, J1
Walsh, AM1
Edwards, HE1
Courtney, MD1
Wilson, JE1
Monaghan, SJ1
Smitherman, LC1
Janisse, J1
Mathur, A1
Huang, X1
Zhang, Z2
Liu, W1
Tang, S1
Han, X1
Su, F1
Nguyen, ND1
Wang, Z1
Cai, Y1
Rogiers, P1
Vincent, JL1
Zylicz, Z1
Krajnik, M1
Taéron, C1
Reilly, DR1
Oppenheimer, LW1
Humphreys, BD1
Forman, JP1
Zandi-Nejad, K1
Bazari, H1
Seifter, J1
Magee, CC1
Charkaluk, ML1
Kalach, N1
El Kohen, R1
Kremp, O1
Guignard, E1
Djahnine, SR1
Cotting, JQ1
Yersin, C1
Di Paolo, ER1
Krahenbuhl, JD1
Pannatier, A1
Sanders, RP1
Maddirala, SD1
Geiger, TL2
Pounds, S1
Sandlund, JT1
Ribeiro, RC1
Pui, CH1
Howard, SC2
Tamim, H2
Sabra, R2
Mahfoud, Z2
Malaeb, S1
Fakih, H1
Mikati, M2
Bachert, C1
Chuchalin, AG1
Eisebitt, R1
Netayzhenko, VZ1
Schulman, CI1
Namias, N1
Doherty, J1
Manning, RJ1
Li, P2
Elhaddad, A1
Alhaddad, A1
Lasko, D1
Amortegui, J1
Dy, CJ1
Dlugasch, L1
Baracco, G1
Cohn, SM1
Sarrell, EM1
Wielunsky, E1
Cohen, HA1
Erlewyn-Lajeunesse, MD1
Coppens, K1
Hunt, LP1
Chinnick, PJ1
Higginson, IM1
Benger, JR1
Okumura, A1
Fukumoto, Y1
Hayakawa, F1
Nakano, T1
Higuchi, K1
Kamiya, H1
Watanabe, K1
Morishima, T1
Nabulsi, MM1
Itani, M1
Chamseddine, F1
Duncan, P1
Aref-Adib, G1
Venn, A1
Britton, J1
Davey, G1
Rüster, M1
Kiehntopf, M1
Gröne, HJ1
Wolf, G1
Rodríguez Serna, A1
Astobiza Beobide, E1
González Balenciaga, M1
Azkunaga Santibáñez, B1
Benito Fernández, J1
Mintegi Raso, S1
Derasse, M1
Klein, P1
Weiser, M1
Saphyakhajon, P1
Greene, G1
Schmitt, BD1
Jones, J1
Chesney, R1
Rodarte, A1
Bilenko, N1
Tessler, H1
Okbe, R1
Press, J1
Gorodischer, R1
Eccles, R1
Yadav, MR1
Nimekar, DM1
Ananthakrishnan, A1
Brahmkshatriya, PS1
Shirude, ST1
Giridhar, R1
Parmar, A1
Balaraman, R1
Hugosson, E1
Montgomery, SM1
Premji, Z1
Troye-Blomberg, M1
Björkman, A1
Loeb, M1
Slettevoll, J1
Lingjaerde, OC1
Fetveit, A1
Ranganathan, SS1
Sathiadas, MG1
Sumanasena, S1
Fernandopulle, M1
Lamabadusuriya, SP1
Fernandopulle, BM1
Suzuki, E1
Ichihara, K1
Johnson, AM1
Erhan, E1
Inal, MT1
Aydinok, Y1
Balkan, C1
Yegul, I1
Fernandez, A1
Schmidt, JM1
Claassen, J1
Pavlicova, M1
Huddleston, D1
Kreiter, KT1
Ostapkovich, ND1
Kowalski, RG1
Parra, A1
Connolly, ES1
Mayer, SA1
Wright, AD1
Liebelt, EL2
Duhamel, JF1
Le Gall, E1
Dalphin, ML1
Payen-Champenois, C1
Alves, JG1
Cardoso Neto, FJ1
Almeida, CD1
Almeida, ND1
Wong, AA1
Davis, JP1
Schluter, PJ1
Henderson, RD1
O'Sullivan, JD1
Read, SJ2
Green, JL1
Bogdan, GM1
Knox, PC1
Palmer, RB1
Heard, K1
Slattery, JT1
Dart, RC2
Deligne, J1
Grimaldi, L1
Jonville-Béra, AP1
Giraudeau, B1
Blum-Boisgard, C1
Autret-Leca, E2
Feleder, C2
Perlik, V2
Blatteis, CM2
Walsh, A1
Edwards, H1
Fraser, J1
Balci, Y1
Tok, M1
Kocaturk, BK1
Yenilmez, C1
Yirulmaz, C1
Warren, B1
Gibb, IA1
Goulder, MA1
Miller, AA1
Lowe, CM1
Grube, RR1
Scates, AC1
Brown, JM1
Udomphorn, Y1
Suz, P1
Vavilala, MS1
Hata, JS1
Shelsky, CR1
Hindman, BJ1
Smith, TC1
Simmons, JS1
Todd, MM1
Hu, YJ1
Sun, GM1
Hahn, Y1
Chaim, AB1
Brandriss, N1
Verjee, Z1
Mor, A1
Goldman, M1
Gupta, H1
Gupta, P1
Sharma, KK1
Rawat, M1
Ahrenstorf, G1
Burkhardt, O1
Witte, T1
Stoll, M1
Schmidt, RE1
Listernick, R1
Alonso, E1
Goodman, D1
Adler, M1
Katz, B1
Wainwright, M1
Nguyen, P1
Wang, YM1
Huang, MC1
Petitpain, N1
Goffinet, L1
Cosserat, F1
Trechot, P1
Cuny, JF1
Evron, S1
Ezri, T1
Protianov, M1
Muzikant, G1
Sadan, O1
Herman, A1
Szmuk, P1
Eden, AN2
Kaufman, A1
Levy, RL1
Chiarillo, S1
Ames, JT1
Hayden, GF1
Campbell, RE1
Lohr, JA1
Bensaude, I1
Modaï, I1
Petrus, M1
Done, AK2
Gladtke, E1
Addy, DP1
Wilson, G1
Guerra, AJ1
Santos, NT1
Nahata, MC1
Powell, DA1
Durrell, DE1
Miller, MA1
Sweet, L1
Lewis, JM1
Ghosh, JB1
Chatterjee, A1
Mahalanabis, D1
Das, S1
Murphy, MT1
Richards, DB1
Lipton, JM4
Holý, J1
Weiss, J1
Herskowitz, L1
Velásquez-Jones, L1
Jean, R1
Lesbros, D1
Ariole, P1
Jackson, CH1
MacDonald, NC1
Cornett, JW1
de Paillerets, F1
Furioli, J1
Roscioni, C1
De Ritis, G1
Lotti, A1
Pozzessere, C1
De Rossi, P1
Granato, C1
Bruno, VF1
Nola, P1
Morabito, F1
De Tommaso, G1
Pesanti, E1
Roberts, R1
Wilson, JT5
Brown, RD5
Bocchini, JA2
Kearns, GL4
Yaffe, SJ1
Dittmer, A1
Mariani, L1
Baratelli, M1
Mitchell, AA6
Lovejoy, FH2
Slone, D1
Shapiro, S1
Brusquet, Y1
Nezri, M1
Liedtke, RK1
MacKintosh, DA1
Bowie, J1
Baird-Lambert, J1
Buchanan, N1
Suma, V1
Lupone, N1
Beauregard, WG1
Cunietti, E2
Monti, M2
Viganò, A2
D'Aprile, E2
Saligari, A2
Scafuro, E2
Scaricabarozzi, I3
Polidori, G1
Titti, G1
Pieragostini, P1
Comito, A1
Berg, AT1
Shinnar, S1
Shapiro, ED1
Salomon, ME1
Crain, EF1
Hauser, WA1
Jákó, J1
Arató, G1
Cooney, K1
Faschingbauer, C1
Gadomski, AM1
Permutt, T1
Stanton, B1
Stevens, T1
Fitzsimmons, L1
Goodwin, SD1
Cleary, JD1
Walawander, CA1
Taylor, JW1
Grasela, TH1
Rothrock, SG1
Green, SM1
Sugimura, T1
Fujimoto, T1
Motoyama, H1
Maruoka, T1
Korematu, S1
Asakuno, Y1
Hayakawa, H1
Vargas, R2
Maneatis, T1
Bynum, L1
Peterson, C1
McMahon, FG2
Wilairatana, P1
Looareesuwan, S1
Stamm, D1
Mahar, AF1
Allen, SJ1
Milligan, P2
Suthumnirund, S1
Chotpitayasunondh, T1
Sabchareon, A1
Coulter, JB1
Regdon, G2
Szikszay, M1
Gebri, G1
Rodriguez, WJ1
Hall, CB1
Welliver, R1
Simoes, EA1
Ryan, ME1
Stutman, H1
Johnson, G1
Van Dyke, R1
Groothuis, JR1
Arrobio, J1
Gerson, C1
Mazur, LJ1
Kozinetz, CA1
Autret, E3
Breart, G1
Jonville, AP1
Courcier, S2
Lassale, C1
Goehrs, JM2
Uchino, H1
Lundgren, J1
Smith, ML1
Siesjö, BK1
Adam, D1
Stankov, G1
Bernal Ruiz, ML1
Sinues Porta, B1
Lanuza Giménez, J1
Gracia Casanova, M1
Mayayo Dehesa, E1
Bartolomé Rodríguez, M1
Schnaiderman, D1
Lahat, E1
Sheefer, T1
Aladjem, M1
Wilkinson, MF2
Kasting, NW2
Guignard, JP1
Bonadio, WA1
Bellomo, T1
Brady, W1
Smith, D1
Feldman, S1
Perry, CS1
Andrew, M1
Jones, L1
Moffitt, JE1
Lamb, D1
Meschievitz, C1
First, MR1
Schroeder, TJ1
Hariharan, S1
Weiskittel, P1
Kokwaro, GO1
Glazier, AP1
Ward, SA1
Breckenridge, AM1
Edwards, G1
Penna, AC1
Dawson, KP1
Penna, CM1
Alonso, EM1
Sokol, RJ1
Hart, J1
Tyson, RW1
Narkewicz, MR1
Whitington, PF1
McIntyre, J1
Hull, D1
Ghatikar, KN1
Keny, S1
Usgaonkar, NG1
Dubey, NK1
Jajoo, D1
Gupta, A1
Sharma, D2
Reboul-Marty, J1
Henry-Launois, B1
Laborde, C1
Languillat, G1
Launois, R1
Poblete, B1
König, P1
Suter, PM1
Sharber, J1
Aksoylar, S1
Akşit, S1
Cağlayan, S1
Yaprak, I1
Bakiler, R1
Cetin, F1
Gabriel, CM1
Minor, JR1
Vogel, S1
Piscitelli, SC1
Havinga, WH1
Shapovalova, VO1
Chernykh, VP1
St Charles, CS1
Matt, BH1
Hamilton, MM1
Katz, BP1
Simon, HK1
Weinkle, DA1
Melis, R1
Block, S1
Brandts, CH1
Ndjavé, M1
Graninger, W1
Kremsner, PG1
Rajeshwari, K1
Anderson, BJ2
Holford, NH2
Vauzelle-Kervroëdan, F1
d'Athis, P2
Pariente-Khayat, A1
Debregeas, S1
Olive, G1
Zuev, VP2
Minkin, LN2
Evglevskaia, IuP2
Agbolosu, NB1
Cuevas, LE1
Broadhead, RL1
Brewster, D1
Graham, SM1
Salminen, WF1
Voellmy, R1
Roberts, SM1
Kádas, I1
Könczöl, F1
Illés, T1
Leary, PM1
Walker, KG1
van der Meulen, W1
Monteleone, J1
Martínez-Cáceres, EM1
Barrau, M1
Durán, I1
Borrás, C1
Tintoré, M1
Mofenson, HC1
McFee, R1
Caraccio, T1
Greensher, J1
Hayward, J1
Veale, B1
Carley, S1
Goyal, PK1
Chandra, J3
Unnikrishnan, G1
Kumari, S1
Passah, SM1
Howell, TK1
Pernerstorfer, T1
Schmid, R1
Bieglmayer, C1
Eichler, HG1
Kapiotis, S1
Jilma, B1
Stegelman, M1
Houry, D1
Ernst, A1
Weiss, S1
Ledbetter, M1
Cesaro, S1
Bortolotti, F1
Petris, MG1
Brugiolo, A1
Cusinato, R1
Guido, M1
Rossetti, F1
Masiero, L1
Zanesco, L1
Ulukol, B1
Köksal, Y1
Cin, S1
Hochstein, HD1
Halevi, A1
Ben-Amitai, D1
Garty, BZ1
Linder, N1
Sirota, L1
Snapir, A1
Eisen, I1
Davidovitch, N1
Kaplan, G1
Barzilai, A1
Helms, R1
Pickering, BD1
Donahue, L1
Jacqz-Aigrain, E1
Dally Gotfrid, C1
Viner, Y1
Luder, A1
Simmons, DL1
Wagner, D1
Westover, K1
Plaisance, KI2
Kudaravalli, S1
Wasserman, SS1
Levine, MM1
Mackowiak, PA1
Boysen, G1
Christensen, H1
Lal, A1
Gomber, S1
Talukdar, B1
Rumack, BH1
Cranswick, N1
Coghlan, D1
Prescott, LF1
O'Brien, KL1
Schwartz, B1
Vezina, R1
Jain, JK1
Harwood, B1
Meckstroth, KR1
Mishell, DR1
Henker, R1
Rogers, S1
Kramer, DJ1
Kelso, L1
Kerr, M1
Sereika, S1
Gunn, VL1
Taha, SH1
Tréluyer, JM1
Tonnelier, S1
Leclerc, B1
Jolivet-Landreau, I1
Del Vecchio, MT1
Sundel, ER1
Díez Domingo, J1
Burgos Ramírez, A1
Garrido García, J1
Ballester Sanz, A1
Moreno Carretero, E1
Legos, JJ1
Mangoni, AA1
Campbell, CA1
Irving, EA1
Roberts, J1
Barone, FC1
Parsons, AA1
Kasner, SE1
Wein, T1
Piriyawat, P1
Villar-Cordova, CE1
Chalela, JA1
Krieger, DW1
Morgenstern, LB1
Kimmel, SE1
Grotta, JC1
Koennecke, HC1
Wong, A1
Sibbald, A1
Ferrero, F1
Plager, M1
Santolaya, ME1
Escobar, AM1
Campos, S1
Barragán, S1
De León González, M1
Kesselring, GL1
Louik, C1
Vezina, RM1
Ng, DK1
Lam, JC1
Chow, KW1
Rosti, L1
Bhatnagar, SK1
van der Worp, B1
van Gemert, M1
Meijer, R1
Kappelle, J1
Barr, J1
Bulkowstein, M1
Avgil, M1
Greenberg, R1
Matias, A1
Petrov, I1
Bernath, VF1
Anderson, JN1
Silagy, CA1
Reess, J1
Haas, J1
Gabriel, K1
Fuhlrott, A1
Fiola, M1
O'Connor, S1
Tse, SM1
Silverman, ED1
McCrindle, BW1
Yeung, RS1
Kapoor, SK1
Sharma, J1
Batra, B1
Paul, E1
Anand, K1
Figueras Nadal, C1
García de Miguel, MJ1
Gómez Campderá, A1
Pou Fernández, J1
Alvarez Calatayud, G1
Sánchez Bayle, M1
Tarimo, DS1
Minjas, JN1
Bygbjerg, IC1
Thabet, F1
Durand, P1
Chevret, L1
Fabre, M1
Debray, D1
Brivet, M1
Devictor, D1
Similä, S6
Keinänen, S4
Kouvalainen, K4
Reynolds, WW1
Dinarello, CA1
Kennedy, JI1
Dascombe, MJ2
Milton, AS6
Philipp-Dormston, WK1
Götte, R1
Liedtke, R1
Austin, TW1
Truant, G1
Lock, A1
Eckman, BM1
Ayres, J1
Ameer, B1
Greenblatt, DJ1
Hietula, M1
Dressler, F1
Skjøtø, J1
Reikvam, A1
Vernon, S1
Bacon, C1
Weightman, D1
Keinänen-Kiukaanniemi, S1
Luoma, P1
Kangas, L1
Saukkonen, AL1
Schuurmans, D1
Vincent, JE1
Bruinvels, J1
Bonta, IL1
Windofer, A1
Hart, JL1
Morg-Heimering, S1
Nemec, A1
Maron, JJ1
Ickes, AC1
Tomović, D1
Hagmann, R1
Clark, WG4
Cumby, HR2
Windorfer, A1
Vogel, C1
Finco, DC1
Duncan, JR1
Schall, WD1
Prasse, KW1
Feldberg, W5
Saxena, PN1
Shrand, H1
Myers, RD1
Drwal-Klein, LA1
Phelps, SJ1
Chevallier, B1
Parat, S1
Renaud, C1
Gallet, JP1
Choonara, I1
Nunn, AJ1
Barker, C1
Kinmonth, AL1
Fulton, Y1
Campbell, MJ1
Kelley, MT1
Edge, JH1
Cox, S1
Mortensen, ME1
Eichler, VF2
Johnson, VA2
Bertrand, KM2
Kauffman, RE1
Sawyer, LA2
Scheinbaum, ML2
Galletta, G2
Chomilo, F1
Braden, NJ2
D'Apuzzo, V1
Monti, T1
Kramer, MS1
Naimark, LE1
Roberts-Bräuer, R1
McDougall, A1
Leduc, DG1
Leung, AK1
Robson, WL1
Sunderland, R1
Casteels-Van Daele, M1
Liadkov, OV1
Lysov, AG1
Mariinskaia, ND1
Kanter, MI1
Bourrillon, A2
Lowe, BA1
Nicholas, SW1
Sidler, J1
Frey, B1
Baerlocher, K1
Hoza, J2
Rachtan, R1
Starek, A1
Morgan, SP1
Gramolini, C1
Manini, G1
Graham, NM1
Burrell, CJ1
Douglas, RM1
Debelle, P1
Davies, L1
Hopkins, CS1
Underhill, S1
Booker, PD1
Cervinka, L1
Schaffer, SJ1
Joshi, YM1
Sovani, VB1
Joshi, VV1
Navrange, JR1
Benakappa, DG1
Shivananda, P1
Sankaranarayanan, VS1
Isaacs, SN1
Axelrod, PI1
Lorber, B1
Guberman, D1
Long, SS1
Deforest, A1
Smith, DG1
Lazaro, C1
Wassilak, GF1
Friedman, AD2
Barton, LL2
Weston, HJ1
Wallander, KA1
Porter, JD1
Robinson, PH1
Glasgow, JF2
Banks, JH1
Hall, SM2
Cedrato, AE1
Passarelli, I1
Cimollini, L1
Maccarone, H1
Deeter, LB1
Martin, LW1
Alexander, L1
Blumenberg, D1
Baker, RC1
Tiller, T1
Bausher, JC1
Bellet, PS1
Cotton, WH1
Finley, AH1
Lenane, AM1
McHenry, C1
Perez, KK1
Shapiro, RA1
Chitty, D1
Cullen, S1
Kenny, D1
Ward, OC1
Sabra, K1
Hietala, J1
Viljanen, MK1
Rosenthal, TC1
Silverstein, DA1
Frank, OR1
Coulthard, KP1
Brauer, H1
Foote, RW1
Achini, R1
Römer, D1
Mitra, A1
Ravikumar, VC1
Bourn, WM1
Bourcier, DR1
Childs, C1
Little, RA1
Ipp, MM1
Gold, R1
Greenberg, S1
Goldbach, M1
Kupfert, BB1
Lloyd, DD1
Maresky, DC1
Saunders, N1
Wise, SA1
Weisse, ME1
Miller, G1
Brien, JH1
Plaster, PA1
Hancock, P1
Feng, J1
Baker, MD1
Fosarelli, PD1
Carpenter, RO1
Gribetz, B1
Cronley, SA1
Goulden, KJ1
Banco, L1
Torrey, SB1
Henretig, F1
Fleisher, G1
Goldstein, RM1
Ardire, A1
Ludwig, S1
Ruddy, R1
Gray, JD1
Blaschke, TF1
Desai, RZ1
Weippl, G1
Michos, N1
Sundal, EJ1
Stocker, H1
Kylmämaa, T1
Remington, PL1
Rowley, D1
McGee, H1
Hall, WN1
Monto, AS1
Koren, G1
Lavi, S1
Rose, V1
Rowe, R1
Newman, J1
Taylor, JP1
Gustafson, TL1
Johnson, CC1
Brandenburg, N1
Glezen, WP1
Beaufils, F1
Cotter, DL1
Noe, JM1
Aber, RC1
Dey, PK2
Gupta, KP3
Wendlandt, S5
Davis, NE1
Nachtigall, C1
Fragen, CA1
Tarlin, L1
Landrigan, P1
Babineau, R1
Alpert, JJ1
Vittadini, G1
Hunter, J1
Sutton, E1
Soyka, LF1
Horstmann, W1
Brown, GL1
Ghosh, SK1
Reddy, TA1
Vassena, E1
Chierichetti, S1
Brewer, EJ1
Steele, RW2
Young, FS1
Bass, JW2
Shirkey, HC1
Alderdice, MT1
Gellman, EF1
Kobayashi, S1
Takagi, H1
Tanaka, PT1
Lara, RP1
Preidel, H1
Robinson, PJ1
Rosen, SM1
Meloff, K1
Cashin, CH1
Heading, CE1
Bour, H1

Clinical Trials (38)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients: A Randomized Double-Blind Controlled Study[NCT06061575]Phase 484 participants (Anticipated)Interventional2023-10-31Not yet recruiting
Randomized Control Trial of Intravenous Acetaminophen (OFIRMEV) for the Reduction of Intrapartum Maternal Fever and Fetal Tachycardia[NCT02625454]Phase 2168 participants (Anticipated)Interventional2016-12-31Active, not recruiting
Efficacy of Bromocriptine to Reduce Body Temperature in Febrile Critically-ill Adults With Acute Neurologic Disease: an Open-label, Blinded Endpoint, Randomized Controlled Trial[NCT03496545]Phase 1/Phase 247 participants (Actual)Interventional2018-11-30Completed
[NCT02833584]123 participants (Actual)Interventional2016-09-30Completed
Prospective Comparative Study of the Efficacy of Common Antipyretic Treatments in Febrile Children[NCT02294071]Phase 4120 participants (Anticipated)Interventional2014-12-31Not yet recruiting
A Double-blind, Randomized, Placebo-controlled Phase IV Clinical Study of the Efficacy and Safety of a New Formulation of Paracetamol for the Management of Fever of Infectious Origin[NCT02283203]Phase 480 participants (Actual)Interventional2015-02-28Completed
"Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation: the NEED LESS PAIN Study"[NCT02807623]300 participants (Actual)Interventional2016-09-30Completed
Hypoalgesic Effect of Median Nerve Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group[NCT02596815]51 participants (Actual)Interventional2015-07-31Completed
Hypoalgesic Effect of Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group[NCT02595294]52 participants (Actual)Interventional2015-07-31Completed
Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721]Phase 2/Phase 350 participants (Actual)Interventional2015-07-31Completed
Use of Intravenous Acetaminophen in Adolescents and Pediatrics Undergoing Spinal Fusion Surgery: Randomized Controlled Trial[NCT04959591]Phase 399 participants (Actual)Interventional2021-06-01Completed
Control of Fever in Septic Patients[NCT04227652]140 participants (Actual)Interventional2013-09-03Completed
Acetaminophen vs. Ibuprofen in Children With Asthma[NCT01606319]Phase 3300 participants (Actual)Interventional2013-02-28Completed
Impact of Immediate or Delayed Prophylactic Antipyretic Treatment on the Immunogenicity, Reactogenicity and Safety of GlaxoSmithKline Biologicals' Pneumococcal Vaccine 1024850A and the Co-administered DTPa-combined Vaccines[NCT01235949]Phase 4850 participants (Actual)Interventional2010-11-12Completed
A Multicenter, Randomized, Open-Label, Parallel, Active-Comparator Trial to Determine the Efficacy, Safety, and Pharmacokinetics of Ibuprofen Injection in Pediatric Patients[NCT01002573]Phase 3118 participants (Actual)Interventional2010-07-31Completed
A Phase 4, Randomized, Open-Label Trial To Assess The Impact Of Prophylactic Antipyretic Medication On The Immunogenicity Of 13-Valent Pneumococcal Conjugate Vaccine Given With Routine Pediatric Vaccinations In Healthy Infants[NCT01392378]Phase 4908 participants (Actual)Interventional2011-08-31Completed
Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.[NCT02280239]Phase 410 participants (Actual)Interventional2015-05-31Terminated (stopped due to Only enrolled 10 participants over 9 months which is less then anticipated (75).)
Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: a Randomized Controlled Trial[NCT01869699]Phase 441 participants (Actual)Interventional2013-09-30Completed
A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755]62 participants (Actual)Interventional2017-07-01Completed
Multicentre Study to Assess the Effect of Prophylactic Antipyretic Treatment on the Rate of Febrile Reactions Following Concomitant Administration of GSK Biologicals' 10-valent Pneumococcal Conjugate, Infanrix Hexa and Rotarix Vaccines[NCT00370318]Phase 3400 participants Interventional2006-09-30Completed
Prophylactic Antipyretic Treatment in Children Receiving Booster Dose of Pneumococcal Vaccine GSK1024850A and DTPa-HBV-IPV/Hib Vaccine (Infanrix Hexa) and Assessment of Impact of Pneumococcal Vaccination on Nasopharyngeal Carriage[NCT00496015]Phase 3750 participants (Actual)Interventional2007-07-02Completed
Effective Analgesia Using the 5 S's During Routine Immunizations at 2 and 4 Months[NCT01368861]230 participants (Actual)Observational2010-06-30Completed
A Randomized Open Label Mechanistic Study in Atopic Dermatitis to Assess the Immunogenicity of Fluzone® Intradermal and Intramuscular Vaccines[NCT01737710]368 participants (Actual)Interventional2012-10-31Completed
Oral Versus Intravenous Acetaminophen for Postoperative Pain Management After Oocyte Retrieval Procedure. A Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT04662567]42 participants (Actual)Interventional2021-03-12Terminated (stopped due to It was determined that the study should not continue as the study drug, Acetaminophen, could only be mixed in a solvent that would not allow the patients to be NPO prior to procedure.)
Ibuprofen Alone and in Combination With Acetaminophen for Treatment of Fever[NCT00267293]Phase 460 participants (Actual)Interventional2006-01-31Completed
The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau[NCT00137566]Phase 40 participants Interventional2004-05-31Active, not recruiting
A Randomized Placebo-controlled Trial of Acetaminophen for Prevention of Post-vaccination Fever in Infants[NCT00325819]Phase 3374 participants (Actual)Interventional2006-05-31Completed
Assessment of the Safety of Anti-pyretic Therapy in Critically Ill Adults[NCT01173367]Phase 226 participants (Actual)Interventional2010-08-31Completed
Early Lactate-Directed Therapy on the ICU: A Randomized Controlled Trial[NCT00270673]Phase 3350 participants (Anticipated)Interventional2006-02-28Completed
Randomized, Double-Blind, Placebo-Controlled Study of Effects of Combined Spinal Epidural Analgesia on Intrapartum Fever.[NCT00802646]0 participants (Actual)Interventional2009-06-30Withdrawn (stopped due to study moved to alternate site)
A Trial of Prednisone and Acetaminophen Versus Acetaminophen Alone in Minimizing Flu-like Symptoms From Pegylated Interferon Beta-1a[NCT03424733]Phase 450 participants (Anticipated)Interventional2017-09-25Recruiting
An Open-label, Single-dose, Pharmacokinetic Study of Acetaminophen/Naproxen Sodium Fixed Combination Tablets in Adolescents 12 to <17 Years of Age With Orthodontic Pain[NCT05844995]Phase 130 participants (Anticipated)Interventional2023-09-13Recruiting
Postoperative Ibuprofen and the Risk of Bleeding After Tonsillectomy With or Without Adenoidectomy[NCT01605903]Phase 2741 participants (Actual)Interventional2012-05-03Completed
Comparing Narcotics With Non-steroidal Anti-inflammatory Drugs (NSAIDS) Post-operatively in Pediatric Patients Undergoing Adenotonsillectomy[NCT02296840]Phase 445 participants (Actual)Interventional2014-11-30Terminated
Postoperative Ibuprofen Use and Risk of Bleeding in Pediatric Tonsillectomy[NCT03385057]Phase 10 participants (Actual)Interventional2018-09-30Withdrawn (stopped due to Study design flaws; research design needed to be reconfigured)
Randomised, Double-Blind, Placebo Controlled Study of the Antipyretic Effect of Ibuprofen in Children With Uncomplicated Malaria[NCT00167713]Phase 450 participants Interventional2003-04-30Completed
Comparison of Supportive Therapies for Symptom Relief From Pediatric Upper Respiratory Infections (URIs)[NCT01814293]0 participants (Actual)Interventional2013-05-31Withdrawn (stopped due to loss of funding. No data was collected.)
A Full-Factorial, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose Efficacy and Safety Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen, and Naproxen Sodium in Postoperative Dental Pain[NCT05761574]Phase 3440 participants (Anticipated)Interventional2023-05-22Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Temperature Burden

Mean total body temperature burden above 37°C over 48 hours during which patient receives either control or intervention medication. (NCT03496545)
Timeframe: over 48 hours

InterventionTemperature in degrees Celsius (Mean)
Acetaminophen37.8
Bromocriptine and Acetaminophen37.7

Total Time That Temperature is ≥ 38.3ºC

Time in minutes where the temperature is ≥ 38.3ºC during the 48 hours of control versus intervention administration. (NCT03496545)
Timeframe: 48 hours

InterventionMinutes (Mean)
Acetaminophen216
Bromocriptine and Acetaminophen300

Total Time to First Temperature < 37.5ºC

Time in minutes it took after medication administration for the temperature to reach < 37.5ºC. (NCT03496545)
Timeframe: 48 hours

InterventionMinutes (Mean)
Acetaminophen253.5
Bromocriptine and Acetaminophen556

Incidence of Adverse Events - Symptomatic Hypotension, Nausea and Headache

Episodes of symptomatic hypotension, including decrease in supine systolic and diastolic pressures of greater than 20mm and 10mm Hg respectively with patient reported accompanying symptoms of light headedness or dizziness and incidence of nausea and headache. (NCT03496545)
Timeframe: Nursing assessment at every shift during 48 hour study period after first drug administration

,
InterventionParticipants (Count of Participants)
Decrease in blood pressureNauseaHeadache
Acetaminophen1228
Bromocriptine and Acetaminophen17312

Participants With Edema

Swelling at vaccination site (NCT02807623)
Timeframe: baseline, 48-72 hours, and 21- 28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Participants With Erythema

Reddening of the skin at vaccination site reported as the total number of participants with erythema over the duration of the study. (NCT02807623)
Timeframe: baseline, 48- 72 hours, 21-28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Lactate

A Lactate meter was used to test the exercise group for lactate readings. Two lactate tests was performed for the exercise group at Visit 1, both pre and post Influenza vaccination. The first lactate reading was taken after the blood draw.The second lactate reading was obtained from a fingerstick from the hand opposite to the vaccination arm, ideally within 3-8 minutes after the study subject completes pushups. (NCT02807623)
Timeframe: Immediately prior to Influenza vaccine and 3-8 minutes after Influenza vaccine was administered and after push-ups were completed.

Interventionmmol/L (Mean)
Lactate before pushupsLactate after pushups
Compound Exercise of Push-ups1.517.69

Level of Pain

Level of Pain will be measured by validated pain scale, using a scale of 0 ( best, no pain) to 10 (worst, as bad as imaginable, completely interferes). (NCT02807623)
Timeframe: baseline, 48-72 hours and at 21-28 days ( 3 points )

,,
Interventionunits on a scale (Mean)
Visit 1Visit 2Visit 3
Compound Exercise of Push-ups.14.19.13
Ibuprofen.39.56.28
Placebo.19.22.06

Serologic Response - A/California/7/2009

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups214.80345.09
Ibuprofen171.00239.25
Placebo216.75343.03

Serologic Response - A/Hong Kong / 4801/2014

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups149.22232.58
Ibuprofen177.78243.13
Placebo221.09296.66

Serologic Response - B/Brisbane/60/2008

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups26.0041.02
Ibuprofen17.4125.47
Placebo26.0934.09

Serologic Response - B/Phuket/3073/2013

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups32.8949.07
Ibuprofen40.1647.34
Placebo36.6944.78

Asthma Control Days

proportion of study days on which asthma was controlled, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventionproportion of days (Mean)
Acetaminophen.86
Ibuprofen.87

Asthma Rescue Medication Use

average albuterol rescue use per week, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventioninhalations per week (Mean)
Acetaminophen2.8
Ibuprofen3

Exacerbation Frequency

the number of asthma exacerbations requiring systemic corticosteroids (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventionasthma exacerbations per 46 weeks (Mean)
Acetaminophen0.81
Ibuprofen.87

Health Care Utilization

frequency of unscheduled physician visits, emergency department visits or hospitalizations for asthma (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Interventionunscheduled health visits per 46 weeks (Mean)
Acetaminophen.75
Ibuprofen.76

Antibody Concentrations Against Hepatitis B Surface Antigen (HBs)

Antibody concentrations assessed were presented as geometric mean concentrations (GMCs) and expressed in milli-international units per milliliter (mIU/mL). The seroprotection cut-off for the assay was an antibody concentration ≥ 10 mIU/mL. (NCT01235949)
Timeframe: One month after primary immunization (Month 3)

InterventionmIU/mL (Geometric Mean)
IIBU Group911.85
DIBU Group1139.1
NIBU Group1245.07
IPARA Group934.65
DPARA Group674.25
NPARA Group1027.79

Antibody Concentrations Against Polyribosyl-ribitol-phosphate (PRP)

Antibody concentrations assessed were presented as geometric mean concentrations (GMCs) and expressed in micrograms per milliliter (µg/mL). The seroprotection cut-off for the assay was an antibody concentration ≥ 0.15 µg/mL. (NCT01235949)
Timeframe: One month after primary immunization (Month 3)

Interventionµg/mL (Geometric Mean)
IIBU Group3.994
DIBU Group3.66
NIBU Group4.51
IPARA Group3.29
DPARA Group4.23
NPARA Group5.007

Antibody Concentrations Against Protein D (Anti-PD)

Anti-PD antibody concentrations were presented as geometric mean concentrations (GMCs), expressed in ELISA units (EL.U) per milliliter (EL.U/mL). The seropositivity cut-off of the assay was an antibody concentration ≥ 100 EL.U/mL. (NCT01235949)
Timeframe: One month after primary immunization (At Month 3)

InterventionEL.U/mL (Geometric Mean)
IIBU Group1461.3
DIBU Group1353.1
NIBU Group1557.7
IPARA Group1109.6
DPARA Group1348.6
NPARA Group1667.9

Number of Subjects With Any Serious Adverse Events (SAEs)

SAEs assessed include medical occurrences that results in death, are life threatening, require hospitalization or prolongation of hospitalization, results in disability/incapacity. (NCT01235949)
Timeframe: During the entire study period (Month 0 to 10)

InterventionParticipants (Count of Participants)
IIBU Group4
DIBU Group4
NIBU Group2
IPARA Group4
DPARA Group1
NPARA Group0

Number of Subjects With Any Unsolicited Adverse Events (AEs)

An unsolicited adverse event is any adverse event (i.e. any untoward medical occurrence in a patient or clinical investigation subject, temporally associated with use of a medicinal product, whether or not considered related to the medicinal product) reported in addition to those solicited during the clinical study and any solicited symptom with onset outside the specified period of follow-up for solicited symptoms. (NCT01235949)
Timeframe: Within 31-days (Day 0-30) following booster vaccination

InterventionSubjects (Number)
IIBU-IIBU Group6
IIBU-DIBU Group6
IIBU-NIBU Group2
DIBU-IIBU Group3
DIBU-DIBU Group3
DIBU-NIBU Group4
NIBU-IIBU Group6
NIBU-DIBU Group6
NIBU-NIBU Group3
IPARA-NPARA Group4
DPARA-IPARA Group0
NPARA-IPARA Group2

Number of Subjects With Any Unsolicited Adverse Events (AEs)

An unsolicited adverse event is any adverse event (i.e. any untoward medical occurrence in a patient or clinical investigation subject, temporally associated with use of a medicinal product, whether or not considered related to the medicinal product) reported in addition to those solicited during the clinical study and any solicited symptom with onset outside the specified period of follow-up for solicited symptoms. (NCT01235949)
Timeframe: Within 31-days (Day 0-30) following each primary vaccination dose

InterventionParticipants (Count of Participants)
IIBU Group28
DIBU Group33
NIBU Group35
IPARA Group16
DPARA Group4
NPARA Group13

Antibody Concentrations Against Cross-reactive Pneumococcal Serotypes 6A and 19A

Anti-pneumococcal serotype 6A and 19A antibody concentrations have been assessed by 22F-inhibition ELISA, presented as geometric mean concentrations (GMCs) and expressed in micrograms per milliliter (μg/mL). The seropositivity cut-off for the assay was an antibody concentration ≥ 0.05 μg/mL. (NCT01235949)
Timeframe: One month after primary immunization (At Month 3)

,,,,,
Interventionμg/mL (Geometric Mean)
Anti-6AAnti-19A
DIBU Group0.180.2
DPARA Group0.120.17
IIBU Group0.170.23
IPARA Group0.110.15
NIBU Group0.150.16
NPARA Group0.190.25

Antibody Concentrations Against Diphteria (D) and Tetanus (T) Toxoids

Anti-D and anti-T antibody concentrations were presented as geometric mean concentrations (GMCs) and expressed in IU/mL. The seroprotection cut-off for the assay was an antibody concentration ≥ 0.1 IU/mL. (NCT01235949)
Timeframe: Prior to (Month 9) and one month after booster vaccination (Month 10)

,,,,,,,,,,,
InterventionIU/mL (Geometric Mean)
Anti-D, M9Anti-D, M10Anti-T, M9Anti-T, M10
DIBU-DIBU Group0.5815.8310.8687.269
DIBU-IIBU Group0.555.9260.6817.092
DIBU-NIBU Group0.6286.4860.6926.522
DPARA-IPARA Group0.5466.4770.6987.431
IIBU-DIBU Group0.5935.2570.7356.887
IIBU-IIBU Group0.7367.4920.8388.03
IIBU-NIBU Group0.6167.570.667.283
IPARA-NPARA Group0.6657.2380.6666.491
NIBU-DIBU Group0.6277.2260.88310.8
NIBU-IIBU Group0.7147.0590.8437.095
NIBU-NIBU Group0.6568.2060.8589.045
NPARA-IPARA Group0.6426.7490.97.423

Antibody Concentrations Against Diphtheria (D) and Tetanus (T) Toxoids

Anti-D and anti-T antibody concentrations were presented as geometric mean concentrations (GMCs) and expressed in international units per milliliter (IU/mL). The seroprotection cut-off for the assay was an antibody concentration ≥ 0.1 IU/mL. (NCT01235949)
Timeframe: One month after primary immunization (Month 3)

,,,,,
InterventionIU/mL (Geometric Mean)
Anti-DAnti-T
DIBU Group2.9383.373
DPARA Group2.8913.058
IIBU Group3.3263.746
IPARA Group3.0622.943
NIBU Group3.1323.961
NPARA Group3.4573.762

Antibody Concentrations Against Hepatitis B Surface Antigen

Antibody concentrations assessed were presented as geometric mean concentrations (GMCs) and expressed in mIU/mL. The seroprotection cut-off for the assay was an antibody concentration ≥ 10 mIU/mL. (NCT01235949)
Timeframe: Prior to (Month 9) and one month after booster vaccination (Month 10)

,,,,,,,,,,,
InterventionmIU/mL (Geometric Mean)
Anti-HBs, M9Anti-HBs, M10
DIBU-DIBU Group225.012492.42
DIBU-IIBU Group136.531685.87
DIBU-NIBU Group194.512107.75
DPARA-IPARA Group199.572003.09
IIBU-DIBU Group210.321898.54
IIBU-IIBU Group197.461949.42
IIBU-NIBU Group164.331970.6
IPARA-NPARA Group128.122078.63
NIBU-DIBU Group244.522579.59
NIBU-IIBU Group226.11851.22
NIBU-NIBU Group159.793244.33
NPARA-IPARA Group209.272218.23

Antibody Concentrations Against Pertussis Toxoid (Anti-PT), Filamentous Haemagglutinin (Anti-FHA) and Pertactin (Anti-PRN)

Antibody concentrations assessed were presented as geometric mean concentrations (GMCs) and expressed in ELISA units per milliliter (EL.U/mL). The seropositivity cut-off for the assay was an antibody concentration ≥ 5 EL.U/mL. (NCT01235949)
Timeframe: One month after primary immunization (Month 3)

,,,,,
InterventionEL.U/mL (Geometric Mean)
Anti-PTAnti-FHAAnti-PRN
DIBU Group64.2171.6114.3
DPARA Group63.1196.5106.2
IIBU Group59.1163.1103.9
IPARA Group60.417197.1
NIBU Group65191.1118.1
NPARA Group61.5168.9114

Antibody Concentrations Against Pertussis Toxoid (Anti-PT), Filamentous Haemagglutinin (Anti-FHA) and Pertactin (Anti-PRN)

Antibody concentrations assessed were presented as geometric mean concentrations (GMCs) and expressed in ELISA units per milliliter (EL.U/mL). The seropositivity cut-off for the assay was an antibody concentration ≥ 5 EL.U/mL. (NCT01235949)
Timeframe: Prior to (Month 9) and one month after booster vaccination (Month 10)

,,,,,,,,,,,
InterventionEL.U/mL (Geometric Mean)
Anti-PT, M9Anti-PT, M10Anti-FHA, M9Anti-FHA, M10Anti-PRN, M9Anti-PRN, M10
DIBU-DIBU Group14.275.559.3322.925.1246.2
DIBU-IIBU Group14.772.353.8359.822.4262.9
DIBU-NIBU Group13.674.857.7332.716184.3
DPARA-IPARA Group10.866.848.5332.919.7214.2
IIBU-DIBU Group12.864.442.6252.716173.5
IIBU-IIBU Group13.373.846.1308.815.7218.6
IIBU-NIBU Group10.556.642.6327.218.3225.9
IPARA-NPARA Group1359.450.832120.1205.1
NIBU-DIBU Group1274.945.7338.618.8255.7
NIBU-IIBU Group12.863.457.9312.319.4226.7
NIBU-NIBU Group15.297.659.1442.827.3330.4
NPARA-IPARA Group14.25752.9294.220.3213.6

Antibody Concentrations Against Polyribosyl-ribitol-phosphate (PRP)

Antibody concentrations assessed were presented as geometric mean concentrations (GMCs) and expressed in µg/mL. The seroprotection cut-off for the assay was an antibody concentration ≥ 0.15 µg/mL. (NCT01235949)
Timeframe: Prior to (Month 9) and one month after booster vaccination (Month 10)

,,,,,,,,,,,
Interventionµg/mL (Geometric Mean)
Anti-PRP, M9Anti-PRP, M10
DIBU-DIBU Group0.84718.987
DIBU-IIBU Group0.82420.28
DIBU-NIBU Group0.76317.544
DPARA-IPARA Group0.65121.602
IIBU-DIBU Group0.68417.484
IIBU-IIBU Group0.87821.964
IIBU-NIBU Group0.67821.277
IPARA-NPARA Group0.69616.682
NIBU-DIBU Group0.7233.45
NIBU-IIBU Group0.79820.659
NIBU-NIBU Group1.01322.083
NPARA-IPARA Group0.95323.277

Antibody Concentrations Against Protein D (Anti-PD)

Anti-PD antibody concentrations were presented as geometric mean concentrations (GMCs), expressed in ELISA units per milliliter (EL.U//mL). The seroprotection cut-off for the assay was an antibody concentration ≥ 100 EL.U/mL. (NCT01235949)
Timeframe: Prior to (Month 9) and one month after booster vaccination (Month 10)

,,,,,,,,,,,
InterventionEL.U/mL (Geometric Mean)
Anti-PD, M9Anti-PD M10
DIBU-DIBU Group5901664.8
DIBU-IIBU Group622.91888.7
DIBU-NIBU Group5021540.7
DPARA-IPARA Group525.41517.3
IIBU-DIBU Group660.41980.1
IIBU-IIBU Group661.62069
IIBU-NIBU Group588.31907.5
IPARA-NPARA Group446.11482.7
NIBU-DIBU Group555.11953.1
NIBU-IIBU Group752.12319.7
NIBU-NIBU Group777.22285.5
NPARA-IPARA Group691.32082.5

Antibody Concentrations Against Vaccine Pneumococcal Serotypes

Anti- pneumococcal serotypes 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F antibody concentrations have been assessed by 22F-inhibition ELISA, presented as geometric mean concentrations (GMCs) and expressed in micrograms per milliliter (μg/mL). The seropositivity cut-off for the assay was an antibody concentration greater than or equal to (≥) 0.05 μg/mL. (NCT01235949)
Timeframe: Prior to (Month 9) and one month after booster vaccination (Month 10)

,,,,,,,,,,,
Interventionμg/mL (Geometric Mean)
Anti-1, M9Anti-1, M10Anti-4, M9Anti-4, M10Anti-5, M9Anti-5, M10Anti-6B, M9Anti-6B M10Anti-7F, M9Anti-7F M10Anti-9V, M9Anti-9V M10Anti-14, M9Anti-14 M10Anti-18C M9Anti-18C M10Anti-19F M9Anti-19F M10Anti-23F M9Anti-23F M10Anti-6A, M9Anti-6A M10Anti-19A M9Anti-19A M10
IIBU-NIBU Group0.272.390.553.220.764.110.542.430.894.20.833.941.065.160.967.781.726.910.412.590.251.140.221.05
IPARA-NPARA Group0.311.760.523.270.592.620.431.740.843.890.743.111.184.720.916.181.565.940.472.50.190.810.210.74
NIBU-DIBU Group0.383.040.734.080.843.920.582.321.315.550.923.881.936.561.3911.291.77.260.693.170.280.990.20.93
NIBU-IIBU Group0.442.840.724.040.834.210.562.161.075.431.094.071.66.031.127.151.255.240.613.120.261.030.150.67
NIBU-NIBU Group0.432.840.624.070.964.480.672.511.114.931.094.051.956.31.238.681.97.340.583.330.341.40.280.97
NPARA-IPARA Group0.452.840.844.280.854.330.612.290.974.520.973.91.865.621.318.171.726.660.523.150.240.980.241.11
DIBU-DIBU Group0.422.440.723.630.763.330.622.181.14.361.033.161.75.081.17.161.545.270.52.160.321.090.20.66
DIBU-IIBU Group0.382.690.634.050.783.420.552.131.084.961.033.471.314.541.088.231.585.350.552.930.260.890.240.75
DIBU-NIBU Group0.341.870.643.410.73.370.61.521.093.930.933.071.734.611.037.11.385.570.652.740.320.740.240.95
DPARA-IPARA Group0.32.140.63.310.723.580.431.840.984.630.933.491.535.521.148.661.515.540.432.530.220.870.190.63
IIBU-DIBU Group0.362.230.633.650.833.90.441.970.964.20.833.31.745.621.038.061.666.640.643.080.180.860.231.1
IIBU-IIBU Group0.412.870.714.090.984.50.632.751.335.751.074.461.766.021.139.351.946.90.653.720.311.360.281.11

Antibody Concentrations Against Vaccine Pneumococcal Serotypes

Anti-pneumococcal serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F antibody concentrations have been assessed by 22F-inhibition ELISA, presented as geometric mean concentrations (GMCs) and expressed in micrograms per milliliter (μg/mL). The seropositivity cut-off for the assay was an antibody concentration ≥ 0.05 μg/mL. (NCT01235949)
Timeframe: One month after primary immunization (At Month 3)

,,,,,
Interventionµg/mL (Geometric Mean)
Anti-1Anti-4Anti-5Anti-6BAnti-7FAnti-9VAnti-14Anti-18CAnti-19FAnti-23F
DIBU Group1.712.212.390.762.832.014.523.85.040.92
DPARA Group1.381.952.360.422.451.824.124.085.20.74
IIBU Group1.822.252.930.672.872.14.763.856.111.04
IPARA Group1.321.571.950.492.181.673.443.084.950.77
NIBU Group1.92.212.770.62.772.184.774.344.961.07
NPARA Group1.952.593.050.722.952.45.174.966.981

Antibody Titers Against Poliovirus Type 1, 2 and 3

Antibody titers assessed were presented as geometric mean titers (GMTs). The seroprotection cut-off for the assay was a titer ≥ the value of 8. (NCT01235949)
Timeframe: One month after primary immunization (Month 3)

,,,,,
InterventionTiters (Geometric Mean)
Anti-Polio 1Anti-Polio 2Anti-Polio 3
DIBU Group252.5327.4351.3
DPARA Group166394.8394.8
IIBU Group283.4362423.2
IPARA Group225.6240.7284
NIBU Group337378624.1
NPARA Group449.3335.2438.6

Antibody Titers Against Poliovirus Type 1, 2 and 3

Antibody titers assessed were presented as geometric mean titers (GMTs). The seroprotection cut-off for the assay was a titer ≥ the value of 8. (NCT01235949)
Timeframe: Prior to (Month 9) and one month after booster vaccination (Month 10)

,,,,,,,,,,,
InterventionTiters (Geometric Mean)
Anti-Polio 1, M9Anti-Polio 1, M10Anti-Polio 2, M9Anti-Polio 2, M10Anti-Polio 3, M9Anti-Polio 3, M10
DIBU-DIBU Group45.438841.7512.545.3588.1
DIBU-IIBU Group145.71824.5292.12151.9205.43649.1
DIBU-NIBU Group32.1543.98542.445.21152.5
DPARA-IPARA Group128.31448.1139.61625.4108.11625.4
IIBU-DIBU Group85.9790.760.81217.7861724.5
IIBU-IIBU Group561378.2120.8194972861
IIBU-NIBU Group80.9429.948.3548.7127.8359.5
IPARA-NPARA Group53.81290.129.72047.996.52195
NIBU-DIBU Group53.74119.6434.1139.6724.1
NIBU-IIBU Group67.11217.7134.81217.770558.3
NIBU-NIBU Group141.21075.9156.11393.41282233.3
NPARA-IPARA Group117.4861.1168.91116.669.72048

Number of Subjects With Antibody Concentrations Against Vaccine Pneumococcal Serotypes Greater Than or Equal to (≥) the Cut-off

Antibodies against the vaccine pneumococcal serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F (Anti-1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F) have been assessed by 22F-inhibition enzyme-linked immunosorbent assay (ELISA). The cut-off value of the assay was an antibody concentration greater than or equal to (≥) 0.2 micrograms per milliliter (μg/mL). (NCT01235949)
Timeframe: One month after primary immunization (At Month 3)

,,,,,
InterventionParticipants (Count of Participants)
Anti-1Anti-4Anti-5Anti-6BAnti-7FAnti-9VAnti-14Anti-18CAnti-19FAnti-23F
DIBU Group155155154135157153153153152141
DPARA Group50515037555050505043
IIBU Group144145143121153144144143145136
IPARA Group52535342555353525347
NIBU Group160158156133164155154155157149
NPARA Group55565448565353545450

Number of Subjects With Any and Grade 3 Solicited Local Symptoms

Solicited local symptoms assessed were pain, redness and swelling. Any = incidence of any local symptom regardless of intensity grade. Grade 3 pain = cried when limb was moved/spontaneously painful. Grade 3 redness/swelling = redness/swelling above 30 millimeters (mm). (NCT01235949)
Timeframe: Within the 4-day (Days 0-3) period following booster vaccination

,,,,,,,,,,,
InterventionParticipants (Count of Participants)
Any PainGrade 3 PainAny RednessGrade 3 RednessAny SwellingGrade 3 Swelling
DIBU-DIBU Group16115161
DIBU-IIBU Group222230160
DIBU-NIBU Group252220110
DPARA-IPARA Group244230120
IIBU-DIBU Group223251160
IIBU-IIBU Group250270160
IIBU-NIBU Group15017090
IPARA-NPARA Group234230170
NIBU-DIBU Group321255182
NIBU-IIBU Group284233160
NIBU-NIBU Group284230150
NPARA-IPARA Group241232160

Number of Subjects With Any and Grade 3 Solicited Local Symptoms

Solicited local symptoms assessed were pain, redness and swelling. Any = incidence of any local symptom regardless of intensity grade. Grade 3 pain = cried when limb was moved/spontaneously painful. Grade 3 redness/swelling = redness/swelling above 30 millimeters (mm). (NCT01235949)
Timeframe: Within the 4-day (Days 0-3) post-primary vaccination period following each dose and across doses

,,,,,
InterventionParticipants (Count of Participants)
Any Pain, Dose 1Grade 3 Pain, Dose 1Any Redness, Dose 1Grade 3 Redness, Dose 1Any Swelling, Dose 1Grade 3 Swelling, Dose 1Any Pain, Dose 2Grade 3 Pain, Dose 2Any Redness, Dose 2Grade 3 Redness, Dose 2Any Swelling, Dose 2Grade 3 Swelling, Dose 2Any Pain, Dose 3Grade 3 Pain, Dose 3Any Redness, Dose 3Grade 3 Redness, Dose 3Any Swelling, Dose 3Grade 3 Swelling, Dose 3Any Pain, Across dosesGrade 3 Pain, Across dosesAny Redness, Across dosesGrade 3 Redness, Across dosesAny Swelling, Across dosesGrade 3 Swelling, Across doses
DIBU Group482520220492590330483630320767890510
DPARA Group28219071220230111211252120373352171
IIBU Group4437412916017313115027023619251084613
IPARA Group212240100192240101181280160305360201
NIBU Group788771280676720310524560300107151051570
NPARA Group337320110251312122221272132447462192

Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms

Solicited general symptoms included drowsiness, irritability, loss of appetite and fever [rectally, greater than or equal to (≥) 38 degrees Celsius (°C)]. Any= incidence of any symptom regardless of intensity grade or relationship to vaccination. Grade 3 drowsiness = drowsiness that interfered with normal activity. Grade 3 irritability = crying that could not be comforted/ prevented normal activity. Grade 3 loss of appetite = not eating at all. Grade 3 fever = fever above (>) 40.0°C. Related = symptom assessed by the investigator as related to the vaccination. (NCT01235949)
Timeframe: Within the 4-day (Days 0-3) period following booster vaccination

,,,,,,,,,,,
InterventionParticipants (Count of Participants)
Any DrowsinessGrade 3 DrowsinessRelated DrowsinessAny IrritabilityGrade 3 IrritabilityRelated IrritabilityAny Loss of appetiteGrade 3 Loss of appetiteRelated Loss of appetiteAny FeverGrade 3 FeverRelated Fever
DIBU-DIBU Group909260201511519118
DIBU-IIBU Group1911322313121919017
DIBU-NIBU Group21017273231901720018
DPARA-IPARA Group1601322320101614013
IIBU-DIBU Group18113273181601121017
IIBU-IIBU Group18115331221401122020
IIBU-NIBU Group170132311390415012
IPARA-NPARA Group121102621890821018
NIBU-DIBU Group24018330262401923019
NIBU-IIBU Group22017363272131920018
NIBU-NIBU Group24221323271411228024
NPARA-IPARA Group19016270161701318016

Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms

Solicited general symptoms included drowsiness, irritability, loss of appetite and fever [rectally, greater than or equal to (≥) 38 degrees Celsius (°C)]. Any= incidence of any symptom regardless of intensity grade or relationship to vaccination. Grade 3 drowsiness = drowsiness that interfered with normal activity. Grade 3 irritability = crying that could not be comforted/ prevented normal activity. Grade 3 loss of appetite = not eating at all. Grade 3 fever = fever above (>) 40.0°C. Related = symptom assessed by the investigator as related to the vaccination. (NCT01235949)
Timeframe: Within the 4-day (Days 0-3) post-primary vaccination period following each dose and across doses

,,,,,
InterventionParticipants (Count of Participants)
Any Drowsiness, Dose 1Grade 3 Drowsiness, Dose 1Related Drowsiness, Dose 1Any Irritability, Dose 1Grade 3 Irritability, Dose 1Related Irritability, Dose 1Any Loss appetite, Dose 1Grade 3 Loss appetite, Dose 1Related Loss appetite, Dose 1Any Fever, Dose 1Grade 3 Fever, Dose 1Related Fever, Dose 1Any Drowsiness, Dose 2Grade 3 Drowsiness, Dose 2Related Drowsiness, Dose 2Any Irritability, Dose 2Grade 3 Irritability, Dose 2Related Irritability, Dose 2Any Loss appetite, Dose 2Grade 3 Loss appetite, Dose 2Related Loss appetite, Dose 2Any Fever, Dose 2Grade 3 Fever, Dose 2Related Fever, Dose 2Any Drowsiness, Dose 3Grade 3 Drowsiness, Dose 3Related Drowsiness, Dose 3Any Irritability, Dose 3Grade 3 Irritability, Dose 3Related Irritability, Dose 3Any Loss appetite, Dose 3Grade 3 Loss appetite, Dose 3Related Loss appetite, Dose 3Any Fever, Dose 3Grade 3 Fever, Dose 3Related Fever, Dose 3Any Drowsiness, Across dosesGrade 3 Drowsiness, Across dosesRelated Drowsiness, Across dosesAny Irritability, Across dosesGrade 3 Irritability, Across dosesRelated Irritability, Across dosesAny Loss appetite, Across dosesGrade 3 Loss appetite, Across dosesRelated Loss appetite, Across dosesAny Fever, Across dosesGrade 3 Fever, Across dosesRelated Fever, Across doses
DIBU Group783478334954035730566604188558550415504950035685484113031027111372121128298168101084
DPARA Group280173411619111110815012311221108150108052121290770533022434282411627018
IIBU Group713429146151032810586424079356520377606162140743484202646038115677120108684056121090
IPARA Group3312027318110880628016301201207140111801217110905120740126404282401623018
NIBU Group10136510967671043850686324389564471286905545030772574232642035123487138121041003641220101
NPARA Group36124433273212030023251153712522014241191601129017161121401245232594404223040131

Opsonophagocytic Activity (OPA) Titers Against Vaccine Pneumococcal Serotypes

"OPA titers against pneumococcal serotypes (Opsono-1, -4, -5, -6A, -6B, -7F, -9V, -14, -18C, -19A, -19F and -23F) were presented as geometric mean titers (GMTs). The seropositivity cut-off for the assay was ≥ 8. When the number of subjects in a group for a specific category equals (=) 1, the lower limit and upper limit of the confidence interval that can't be calculated, are filled in with the GMT value (due to system constraint). Placeholder value 99999.9 has been entered when value to be entered in the system was greater than (>) 1.0 E10." (NCT01235949)
Timeframe: Prior to (Month 9) and one month after booster vaccination (Month 10)

,,,,,,,,,,,
InterventionTiters (Geometric Mean)
OPSONO-1, M9OPSONO-1, M10OPSONO-4, M9OPSONO-4, M10OPSONO-5, M9OPSONO-5, M10OPSONO-6B, M9OPSONO-6B, M10OPSONO-7F, M9OPSONO-7F, M10OPSONO-9V, M9OPSONO-9V, M10OPSONO-14, M9OPSONO-14, M10OPSONO-18C, M9OPSONO-18C, M10OPSONO-19F, M9OPSONO-19F, M10OPSONO-23F, M9OPSONO-23F, M10OPSONO-6A, M9OPSONO-6A, M10OPSONO-19A, M9OPSONO-19A, M10
IPARA-NPARA Group6120.625.9548.35.742.2127.7431.51290.911414.1567.4856.698.3557.56.5149.911163.389.429746.7154444.3
NIBU-DIBU Group40.2546.252.41149.812.7128.913.7173.111523565.8282.12919.8255.9935.39.4707.924.2273.930.53682.734.1106.94253
NIBU-IIBU Group7.3388.298.11953.47.699.516.4237.6256314362.41075.24218.92951498.131.9428.615572.7499.74249.123.398.14125.7
NIBU-NIBU Group10.762715.21414.19.8184.6182.51047.81263.55829.11571.38601.7382.638175.5481.353.2250.615.61464.158.3120412.8
NPARA-IPARA Group15.7887.6161.8854.422.2149.7239376.51744.77567.3738.71340.1195.4587.514242.748.451137.7875.224.578.54541.6
IIBU-NIBU Group4316.442213.48.2241.784.3769.11762.512162.6649.44756.147.24426.642394.788.52575.222.22792.913.4318.4421.2
DIBU-DIBU Group50.6248407.61037.517.5114.1289.4553.15343.29941.81423.63772.9791.7200221.9650.617.71040.71342096.1224.874.57.429.8
DIBU-IIBU Group50.315892096.7197913.3694.21729.9117411302.74190.8737.11507.611.5397.39.7637.129.72977.7239.5581.1428
DIBU-NIBU Group9.9344.474.21096.710.8165.8208.91021.63522.85744.51081.94970.9539.21312.410.9298.167.81575396.63530.199169.24325.4
DPARA-IPARA Group12.2736.356.31885.97.4125.3105.6904.32256.221670480.97262.2260.7228819.1888.942.31215.3274.51436.284159.19.1416.5
IIBU-DIBU Group4296.380.2865.89.293.3237.2606.21777.34591.41283.87041.7255.1671.47.2207.332.1330.5132.42381.545.1125.444
IIBU-IIBU Group5.8346.234928.112.9131.896.1745.6207616259.98304969149.21592.97.2912.9631112.927.958139.8183.74363.7

Opsonophagocytic Activity (OPA) Titers Against Vaccine Pneumococcal Serotypes

OPA titers against pneumococcal serotypes 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F (Opsono-1, -4, -5, -6A, -6B, -7F, -9V, -14, -18C, -19A, -19F and -23F) were presented as geometric mean titers (GMTs). The seropositivity cut-off for the assay was an antibody titer ≥ 8. (NCT01235949)
Timeframe: One month after primary immunization (Month 3)

,,,,,
InterventionTiters (Geometric Mean)
OPSONO-1OPSONO-4OPSONO-5OPSONO-6BOPSONO-7FOPSONO-9VOPSONO-14OPSONO-18COPSONO-19FOPSONO-23FOPSONO-6AOPSONO-19A
DIBU Group67.91172.352.4882.44977.94040.41219.7167.6514.81105.5151.146.1
DPARA Group941712.470.7140.37306.43777.11780.5382.7254.272334.239.7
IIBU Group69.4131186.67238827.73429.21346.3186.9536.2989.87916.6
IPARA Group23684.838.7739.98362.75520.1591.591.6501.11188.4100.711.2
NIBU Group75.91027.774.3361.36444.82744.21417.9135.9267.9129626.420.4
NPARA Group64.4777.280.8237.16286.12273.21460.1106272.1838.444.511.4

Change From Baseline in Temperature After the First 30 Minutes of Treatment

Change in temperature in patients receiving intravenous ibuprofen and acetaminophen (APAP) after the first 30 minutes of treatment. (NCT01002573)
Timeframe: 30 minutes following treatment

InterventionCelsius (Mean)
Ibuprofen-0.5
Acetaminophen-0.3

Change From Baseline in Temperature After the First 60 Minutes of Treatment

Change in temperature in patients receiving intravenous ibuprofen and APAP after the first 60 minutes of treatment. (NCT01002573)
Timeframe: 60 minutes following treatment

InterventionCelsius (Mean)
Ibuprofen-0.9
Acetaminophen-0.5

Change From Baseline in Temperature After the First Four Hours of Treatment

Change in temperature during the first 4 hours of treatment by assessing the area under the change in temperature versus time curve during the first four hours of treatment (AUC0-4) (NCT01002573)
Timeframe: 0 to 4 hours post-dose

Interventiondegree Celsius*Time (Mean)
Ibuprofen-4.4
Acetaminophen-2.6

Change in Temperature

Change in temperature in patients receiving intravenous ibuprofen and APAP after the first 4 hours of treatment. (NCT01002573)
Timeframe: 4 hours following treatment

InterventionCelsius (Mean)
Ibuprofen-1.5
Acetaminophen-0.9

Fever Reduction

Treatment of fever as measured by the area under the change in temperature versus time curve during the first two hours of treatment (AUC0-2) (NCT01002573)
Timeframe: 0 to 2 hours post-dose

Interventiondegree Celsius*Time (Mean)
Ibuprofen-1.5
Acetaminophen-0.9

Time to Afebrility (in Hours)

Tme to afebrility (temperature less than 100.4 ºF [38 ºC]) in patients receiving intravenous ibuprofen and APAP. (NCT01002573)
Timeframe: 4 Hour post treatment

InterventionHours (Mean)
Ibuprofen2.2
Acetaminophen3.3

Number of Afebrile and Febrile Subject at 4 Hours Post-Dose

Number of Afebrile and Febrile Subject at 4 Hours Following Treatment (NCT01002573)
Timeframe: 4 Hours Post-Dose

,
Interventionparticipants (Number)
Afebrile Subjects at 4 hoursFebrile at 4 Hours
Acetaminophen4011
Ibuprofen433

Geometric Mean Concentration (GMC) for Antigen-specific Haemophilus Influenzae Type b (Hib) Polyribosylribitol Phosphate (PRP) Antibody 1 Month After the Infant Series

Geometric LS mean concentrations (GMCs) and corresponding 2-sided 95% CIs were evaluated for Hib PRP antibody. (NCT01392378)
Timeframe: 1 month after the infant series

Interventionmcg/mL (Geometric Mean)
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily0.54
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily0.59
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily0.49
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily0.51
13vPnC + INFANRIX Hexa0.58

Geometric Mean Concentration (GMC) for Antigen-specific Haemophilus Influenzae Type b (Hib) Polyribosylribitol Phosphate (PRP) Antibody 1 Month After the Toddler Dose

Geometric LS mean concentration (GMCs) were measured in mcg/mL and corresponding 2-sided 95% CIs were evaluated for Hib PRP antibody. (NCT01392378)
Timeframe: 1 month after the toddler dose

Interventionmcg/mL (Geometric Mean)
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily9.65
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily9.35
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily8.25
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily7.84
13vPnC + INFANRIX Hexa8.96

Geometric Mean Concentration (GMC) for Antigen-specific Hepatitis B Virus (HBV) Antibody 1 Month After the Infant Series

Geometric LS mean concentration (GMCs) were measured in milli international units/mL (mIU/mL) and corresponding 2-sided 95% CIs were evaluated for hepatitis B virus (HBV) antibody. (NCT01392378)
Timeframe: 1 month after the infant series

InterventionmIU/mL (Geometric Mean)
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily756.42
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily770.93
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily689.34
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily599.12
13vPnC + INFANRIX Hexa733.29

Geometric Mean Concentration (GMC) for Antigen-specific Hepatitis B Virus (HBV) Antibody 1 Month After the Toddler Dose

Geometric LS mean concentration (GMCs) were measured in mIU/mL and corresponding 2-sided 95% CIs were evaluated for hepatitis B virus (HBV) antibody. (NCT01392378)
Timeframe: 1 month after the toddler dose

InterventionmIU/mL (Geometric Mean)
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily4868.61
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily4148.04
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily4250.41
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily4263.28
13vPnC + INFANRIX Hexa3866.37

Geometric Mean Concentration (GMC) for Antigen-specific Pertussis Toxin (PT), Filamentous Hemagglutinin (FHA) and Pertactin (PRN) Antibodies 1 Month After the Toddler Dose

Geometric LS mean concentration (GMCs) were measured in EU/mL and corresponding 2-sided 95% CIs were evaluated for pertussis (pertussis toxin [PT], filamentous hemagglutinin [FHA] and pertactin [PRN]) antibodies. (NCT01392378)
Timeframe: 1 month after the toddler dose

,,,,
InterventionEU/mL (Geometric Mean)
Pertussis PTPertussis FHAPertussis PRN
13vPnC + INFANRIX Hexa74.01117.01172.80
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily73.38108.11158.71
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily76.93117.87156.98
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily73.72123.56160.96
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily77.43115.55158.28

Geometric Mean Concentration (GMC) for Antigen-specific Pertussis Toxin (PT), Filamentous Hemagglutinin (FHA) and Pertactin (PRN) Antibody 1 Month After the Infant Series

Geometric LS mean concentration (GMCs) were measured in Enzyme-linked Immunosorbent Assay (ELISA) units/mL (EU/mL) and corresponding 2-sided 95% CIs were evaluated for pertussis (pertussis toxin [PT], filamentous hemagglutinin [FHA] and pertactin [PRN]) antibodies. (NCT01392378)
Timeframe: 1 month after the infant series

,,,,
InterventionEU/mL (Geometric Mean)
Pertussis PTPertussis FHAPertussis PRN
13vPnC + INFANRIX Hexa44.8548.4284.57
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily39.2635.5568.53
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily43.5140.6571.26
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily40.2741.3265.82
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily40.8646.2972.90

Geometric Mean Concentration (GMC) for Antigen-specific Tetanus and Diphtheria Antibodies 1 Month After the Toddler Dose

Geometric LS mean concentration (GMCs) were measured in IU/mL and corresponding 2-sided 95% CIs were evaluated for tetanus and diphtheria antibodies. (NCT01392378)
Timeframe: 1 month after the toddler dose

,,,,
InterventionIU/mL (Geometric Mean)
TetanusDiphtheria
13vPnC + INFANRIX Hexa2.661.90
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily2.291.87
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily2.501.94
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily2.601.69
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily2.541.64

Geometric Mean Concentration (GMC) for Antigen-specific Tetanus and Diphtheria Antibody 1 Month After the Infant Series

Geometric LS mean concentration (GMCs) were measured in International Units/mL (IU/mL) and corresponding 2-sided 95% CIs were evaluated for tetanus and diphtheria antibodies. (NCT01392378)
Timeframe: 1 month after the infant series

,,,,
InterventionIU/mL (Geometric Mean)
TetanusDiphtheria
13vPnC + INFANRIX Hexa0.820.65
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily0.600.65
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily0.700.68
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily0.690.61
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily0.730.62

Geometric Mean Concentration (GMC) for Serotype-specific Pneumococcal Immunoglobulin G (IgG) Antibody 1 Month After the Infant Series

Antibody geometric least squares (LS) mean concentrations (GMCs) for 13 pneumococcal serotypes (4, 6B, 9V, 14, 18C, 19F, 23F, 1, 3, 5, 6A, 7F and 19A) are presented. GMC (13vPnC) and corresponding 2-sided 95 percent (%) confidence interval (CI) were evaluated. Geometric means (GMs) were calculated using all participants with available data for the specified blood draw. Here 'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies participants with a determinate IgG concentration to the given serotype for each arm, respectively. (NCT01392378)
Timeframe: 1 month after the infant series

,,,,
Interventionmicrogram per milliliter (mcg/mL) (Geometric Mean)
4 (n = 137, 155, 148, 146, 210)6B (n = 136, 155, 148, 146, 210)9V (n = 138, 155, 148, 147, 210)14 (n = 138, 155, 148, 147, 210)18C (n = 138, 155, 148, 147, 210)19F (n = 138, 155, 148, 147, 210)23F (n= 137, 155, 148, 146, 210)1 (n = 138, 155, 148, 147, 210)3 (n = 138, 155, 148, 147, 210)5 (n = 137, 155, 148, 146, 210)6A (n = 138, 155, 148, 146, 210)7F (n = 138, 155, 148, 146, 210)19A (n = 137, 155, 148, 146, 210)
13vPnC + INFANRIX Hexa2.020.811.315.381.541.991.041.250.880.811.102.153.02
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily2.070.901.405.261.752.041.071.290.840.901.222.283.14
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily1.990.911.454.731.732.301.191.500.830.981.252.223.39
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily1.480.561.174.751.251.590.731.020.570.630.851.832.53
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily1.640.681.134.451.471.780.851.120.710.790.971.942.70

Geometric Mean Concentration (GMC) for Serotype-specific Pneumococcal Immunoglobulin G (IgG) Antibody 1 Month After the Toddler Dose

Antibody geometric LS mean concentrations (GMCs) for 13 pneumococcal serotypes (4, 6B, 9V, 14, 18C, 19F, 23F, 1, 3, 5, 6A, 7F and 19A) are presented. GMC (13vPnC) and corresponding 2-sided 95% CI were evaluated. Geometric means (GMs) were calculated using all participants with available data for the specified blood draw. Here 'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies participants with a determinate IgG concentration to the given serotype for each arm respectively. (NCT01392378)
Timeframe: 1 month after the toddler dose

,,,,
Interventionmcg/mL (Geometric Mean)
4 (n = 130, 144, 143, 139, 206)6B (n = 130, 144, 143, 139, 206)9V (n = 130, 144, 143, 139, 206)14 (n = 130, 144, 143, 139, 206)18C (n = 130, 144, 143, 139, 206)19F (n = 130, 144, 143, 139, 206)23F (n = 130, 144, 142, 139, 206)1 (n = 130, 144, 143, 139, 206)3 (n = 129, 144, 143, 138, 203)5 (n = 130, 144, 143, 139, 206)6A (n = 130, 144, 143, 139, 206)7F (n = 130, 144, 142, 139, 206)19A (n = 129, 144, 142, 139, 206)
13vPnC + INFANRIX Hexa3.107.082.169.101.597.952.753.040.542.845.523.987.71
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily3.437.302.129.121.638.022.863.120.492.625.363.977.35
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily3.438.012.238.401.688.992.963.220.542.755.733.897.99
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily2.976.382.177.951.367.532.372.660.462.405.273.567.31
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily3.076.702.158.101.358.412.342.800.462.335.123.797.11

Geometric Mean Titer (GMT) for Antigen-specific Poliomyelitis Type 1, 2 and 3 Antibodies 1 Month After the Infant Series

Geometric LS mean concentrations (GMCs) were measured as titers and corresponding 2-sided 95% CIs were evaluated for poliomyelitis type 1, 2 and 3 antibodies. (NCT01392378)
Timeframe: 1 month after the infant series

,,,,
Interventiontiter (Geometric Mean)
Poliomyelitis Type 1Poliomyelitis Type 2Poliomyelitis Type 3
13vPnC + INFANRIX Hexa72.0267.37231.02
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily70.6655.17218.85
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily66.5973.52184.03
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily67.4362.12257.92
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily68.1179.60246.22

Geometric Mean Titer (GMT) for Antigen-specific Poliomyelitis Type 1, 2 and 3 Antibodies 1 Month After the Toddler Dose

Geometric LS mean concentration (GMCs) were measured as titers and corresponding 2-sided 95% CIs were evaluated for poliomyelitis type 1, 2 and 3 antibodies. (NCT01392378)
Timeframe: 1 month after the toddler dose

,,,,
Interventiontiter (Geometric Mean)
Poliomyelitis Type 1Poliomyelitis Type 2Poliomyelitis Type 3
13vPnC + INFANRIX Hexa406.37621.071237.86
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily415.45605.781187.11
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily426.63586.301045.57
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily443.97587.561210.29
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily399.56613.181205.80

Geometric Mean Titer (GMT) for Serotype-specific Pneumococcal Opsonophagocytic Activity (OPA) 1 Month After the Infant Series

Antibody-mediated serum OPA against the 13 pneumococcal serotypes (4, 6B, 9V, 14, 18C, 19F, 23F, 1, 3, 5, 6A, 7F and 19A) was measured centrally using a pneumococcal OPA assay. Results were expressed as OPA titers. OPA titers were logarithmically transformed for analysis; geometric means calculated and expressed as geometric mean titers (GMTs). (NCT01392378)
Timeframe: 1 month after the infant series

,,,,
Interventiontiter (Geometric Mean)
4 (n = 37, 46, 42, 41, 61)6B (n = 36, 45, 43, 40, 62)9V (n = 37, 48, 42, 41, 65)14 (n = 38, 48, 41, 41, 64)18C (n = 37, 47, 41, 41, 62)19F (n = 37, 46, 41, 42, 63)23F (n = 38, 45, 42, 42, 63)1 (n = 42, 42, 43, 44, 74)3 (n = 41, 41, 39, 39, 69)5 (n = 42, 43, 44, 42, 73)6A (n = 46, 42, 39, 39, 76)7F (n = 46, 42, 40, 39, 76)19A (n = 42, 44, 41, 42, 74)
13vPnC + INFANRIX Hexa1086748241951109227936612877614622125240
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily136166328599110312943218629912811584159
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily113565516662285322144111769616811907257
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily1240470936508771653328565412281747163
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily1269794120435109434634212728610601766185

Number of Participants With Non-Serious Adverse Events (AEs) and Serious Adverse Events (SAEs): After the Infant Series

An AE was any untoward medical occurrence in a participant who received vaccine without regard to possibility of causal relationship. SAE: an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial/prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly. Treatment-emergent events after the infant series were events between 1 month (28 to 42 days) after infant series to toddler dose that were absent before treatment or that worsened relative to pre-treatment state. Reported non-SAEs included AEs other than SAEs spontaneously collected on case report form (non-systematic assessment). (NCT01392378)
Timeframe: 1 Month (28 to 42 days) after infant series Dose 3 up to toddler dose

,,,,
Interventionparticipants (Number)
Non-SAEsSAEs
13vPnC + INFANRIX Hexa89
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily411
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily614
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily310
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily36

Number of Participants With Non-Serious Adverse Events (AEs) and Serious Adverse Events (SAEs): Infant Series

An AE was any untoward medical occurrence in a participant who received vaccine without regard to possibility of causal relationship. SAE: an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial/prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly. Treatment-emergent events for infant series were events between infant series Dose 1 and up to 1 month (28 to 42 days) after infant series that were absent before treatment or that worsened relative to pre-treatment state. Reported non-SAEs included AEs other than SAEs collected using electronic diary (fever, systematic assessment) and events spontaneously collected on case report form at each visit (non-systematic assessment). (NCT01392378)
Timeframe: Baseline up to 1 Month (28 to 42 days) after infant series

,,,,
Interventionparticipants (Number)
Non-SAEsSAEs
13vPnC + INFANRIX Hexa8010
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily728
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily713
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily6711
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily577

Number of Participants With Non-Serious Adverse Events (AEs) and Serious Adverse Events (SAEs): Toddler Dose

An AE was any untoward medical occurrence in a participant who received vaccine without regard to possibility of causal relationship. SAE: an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial/prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly. Treatment-emergent events for toddler dose were events between toddler dose and up to 1 month (28 to 42 days) after toddler dose that were absent before treatment or that worsened relative to pre-treatment state. Reported non-SAEs included AEs other than SAEs collected using electronic diary (fever, systematic assessment) and events spontaneously collected on case report form at each visit (non-systematic assessment). (NCT01392378)
Timeframe: Toddler dose up to 1 Month (28 to 42 days) after toddler dose

,,,,
Interventionparticipants (Number)
Non-SAEsSAEs
13vPnC + INFANRIX Hexa501
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily761
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily572
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily521
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily473

Percentage of Participants Achieving Pre-specified Criteria for the Concomitant Antigens Contained in INFANRIX Hexa 1 Month After the Infant Series

Percentage of participants achieving pre-specified criteria for concomitant antigens contained in INFANRIX hexa (Hib polyribosylribitol phosphate [PRP] >=0.15 mcg/mL; Hib PRP >=1 mcg/mL; Pertussis PT >=14.6 EU/mL, FHA >=16.1 EU/mL, PRN >=24.0 EU/mL; Tetanus >=0.1 IU/mL; Diphtheria >=0.1 IU/mL; HBV >=10 mIU/mL; Poliomyelitis Type 1, 2, 3 >=1:8 titer) along with the corresponding 95% CIs were presented. Exact 2-sided CI based on the observed proportion of participants. Pre-specified criteria for pertussis was the level that 95% of the participants achieved in 13vPnC + INFANRIX hexa group. (NCT01392378)
Timeframe: 1 month after the infant series

,,,,
Interventionpercentage of participants (Number)
Hib PRP >=0.15 mcg/mL (n= 136, 146, 144, 139, 198)Hib PRP >=1 mcg/mL (n = 136, 146, 144, 139, 198)Pertussis PT >=14.6 EU/mL (n= 132,143,141,131,193)Pertussis FHA >=16.1 EU/mL (n=132,143,141,131,193)Pertussis PRN >=24.0 EU/mL (n=132,143,141,131,193)Tetanus >=0.1 IU/mL (n = 132,143,141,131,193)Diphtheria >=0.1 IU/mL (n = 132,143,141,131,193)HBV >= 10mIU/mL (n = 105,116,120,112,156)PoliomyelitisType1 >=1:8titer (n=89,105,93,84,135)PoliomyelitisType2 >=1:8titer (n=89,105,93,84,135)PoliomyelitisType3 >=1:8titer (n=89,105,93,84,135)
13vPnC + INFANRIX Hexa87.933.895.395.395.399.599.598.799.395.699.3
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily85.628.190.888.589.398.597.799.1100.096.498.8
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily84.237.097.292.387.4100.098.699.198.198.1100.0
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily86.127.191.593.688.7100.099.399.297.895.798.9
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily87.533.893.296.290.9100.0100.0100.097.895.5100.0

Percentage of Participants Achieving Pre-specified Criteria for the Concomitant Antigens Contained in INFANRIX Hexa 1 Month After the Toddler Dose

Percentage of participants achieving pre-specified criteria for concomitant antigens contained in INFANRIX hexa (Hib polyribosylribitol phosphate [PRP] >=0.15 mcg/mL; Hib PRP >=1 mcg/mL; Pertussis PT >=14.8 EU/mL, FHA >=46.5 EU/mL, PRN >=43.5 EU/mL; Tetanus >=0.1 IU/mL; Diphtheria >=0.1 IU/mL; HBV >=10 mIU/mL; Poliomyelitis Type 1, 2, 3 >=1:8 titer) along with the corresponding 95% CIs were presented. Exact 2-sided CI based on the observed proportion of participants. Pre-specified criteria for pertussis was the level that 95% of the participants achieved in 13vPnC + INFANRIX hexa group. (NCT01392378)
Timeframe: 1 month after the toddler dose

,,,,
Interventionpercentage of participants (Number)
Hib PRP >=0.15 mcg/mL (n= 126, 135, 141, 138, 202)Hib PRP >=1 mcg/mL (n = 126, 135, 141, 138, 202)Pertussis PT >=14.8 EU/mL (n= 123,137,141,136,199)Pertussis FHA >=46.5 EU/mL (n=123,137,141,136,199)Pertussis PRN >=43.5 EU/mL (n=123,137,141,136,199)Tetanus >=0.1 IU/mL (n = 123,137,141,136,199)Diphtheria >=0.1 IU/mL (n = 123,137,141,136,199)HBV >= 10 mIU/mL (n = 119,131,133,133,191)Poliomyelitis 1 >=1:8titer (n=123,133,141,136,201)Poliomyelitis 2 >=1:8titer (n=123,133,141,136,201)Poliomyelitis 3 >=1:8titer (n=123,133,141,136,201)
13vPnC + INFANRIX Hexa100.095.095.595.595.5100.0100.099.599.5100.0100.0
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily100.095.7100.092.694.1100.0100.0100.0100.0100.0100.0
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily99.396.399.394.994.9100.0100.098.5100.0100.0100.0
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily100.095.798.693.694.3100.0100.0100.0100.0100.0100.0
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily100.095.297.691.191.9100.0100.0100.099.2100.0100.0

Percentage of Participants Achieving Serotype-specific Pneumococcal Immunoglobulin G (IgG) Antibody Level Greater Than or Equal to (>=)0.35 Microgram Per Milliliter (Mcg/mL) 1 Month After the Infant Series

Percentage of participants achieving predefined antibody threshold >=0.35 mcg/mL along with the corresponding 95% confidence interval (CI) for 13 pneumococcal serotypes (4, 6B, 9V, 14, 18C, 19F, 23F, 1, 3, 5, 6A, 7F and 19A) are presented. Exact 2-sided CI based on the observed proportion of participants. (NCT01392378)
Timeframe: 1 month after the infant series

,,,,
Interventionpercentage of participants (Number)
4 (n = 137, 155, 148, 146, 210)6B (n = 136, 155, 148, 146, 210)9V (n = 138, 155, 148, 147, 210)14 (n = 138, 155, 148, 147, 210)18C (n = 138, 155, 148, 147, 210)19F (n = 138, 155, 148, 147, 210)23F (n = 137, 155, 148, 146, 210)1 (n = 138, 155, 148, 147, 210)3 (n = 138, 155, 148, 147, 210)5 (n = 137, 155, 148, 146, 210)6A (n = 138, 155, 148, 146, 210)7F (n = 138, 155, 148, 146, 210)19A (n = 137, 155, 148, 146, 210)
13vPnC + INFANRIX Hexa98.177.696.299.596.797.688.194.391.084.391.999.5100.0
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily97.379.595.998.695.996.688.494.688.489.791.8100.099.3
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily97.480.099.498.797.499.490.397.489.791.092.399.499.4
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily96.661.595.999.395.395.374.390.581.176.483.197.398.0
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily96.472.894.2100.096.497.186.194.283.384.786.2100.098.5

Percentage of Participants Achieving Serotype-Specific Pneumococcal Opsonophagocytic Activity (OPA) Titers Greater Than or Equal to (>=) Lower Limit of Quantitation (LLOQ) 1 Month After the Infant Series

Percentage of participants achieving serotype-specific pneumococcal OPA titer >= LLOQ, along with the corresponding 95% CIs for 13 pneumococcal serotypes (4, 6B, 9V, 14, 18C, 19F, 23F, 1, 3, 5, 6A, 7F and 19A) are presented. Exact 2-sided CI based on the observed proportion of participants. The OPA LLOQ in titers for each serotype: 1 = 1:18; 3 = 1:12; 4 = 1:21; 5 = 1:29; 6A = 1:37; 6B = 1:43; 7F = 1:210; 9V = 1:345; 14 = 1:35; 18C = 1:31; 19A = 1:18; 19F = 1:48; 23F = 1:13. (NCT01392378)
Timeframe: 1 month after the infant series

,,,,
Interventionpercentage of participants (Number)
4 (n = 37, 46, 42, 41, 61)6B (n = 36, 45, 43, 40, 62)9V (n = 37, 48, 42, 41, 65)14 (n = 38, 48, 41, 41, 64)18C (n = 37, 47, 41, 41, 62)19F (n = 37, 46, 41, 42, 63)23F (n = 38, 45, 42, 42, 63)1 (n = 42, 42, 43, 44, 74)3 (n = 41, 41, 39, 39, 69)5 (n = 42, 43, 44, 42, 73)6A (n = 46, 42, 39, 39, 76)7F (n = 46, 42, 40, 39, 76)19A (n = 42, 44, 41, 42, 74)
13vPnC + INFANRIX Hexa100.096.875.496.9100.095.293.745.9100.086.398.7100.097.3
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily100.092.580.597.697.692.990.529.594.992.9100.097.488.1
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily100.088.966.797.995.787.097.842.997.690.7100.0100.0100.0
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily100.088.459.5100.0100.090.292.930.297.486.4100.0100.090.2
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily100.094.462.289.5100.097.392.147.697.692.993.5100.092.9

Percentage of Participants Reporting Fever Within 4 Days: Infant Series Dose 1

Participants' core (rectal) temperature was collected for 4 days after each vaccination using an electronic diary. Participants' temperature was collected at 6 to 8 hours after vaccination, 6 to 8 hours following that and coincidentally with antipyretic administration for groups receiving antipyretics. Temperature was recorded at bedtime daily for 3 following days (Day 2 to Day 4) and at any time during the 3 days when fever was suspected. The highest temperature for each day was recorded in the e-diary. Incidences of fever were presented in following categories: >=38 but <=39 degree Celsius (degree C), greater than (>) 39 but <=40 degree C and >40 degree C. (NCT01392378)
Timeframe: Within 4 days after infant series Dose 1

,,,,
Interventionpercentage of participants (Number)
Fever >=38, <=39 degree C (n= 149,157,147,155,187)Fever >39, <=40 degree C (n = 138,145,137,146,170)Fever >40 degree C (n = 138,145,137,146,170)
13vPnC + INFANRIX Hexa41.71.20.0
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily34.20.70.0
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily45.21.40.0
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily18.40.70.0
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily32.91.40.0

Percentage of Participants Reporting Fever Within 4 Days: Infant Series Dose 2

Participants' rectal temperature was collected for 4 days after each vaccination using an electronic diary. Participants' temperature was collected at 6 to 8 hours after vaccination, 6 to 8 hours following that and coincidentally with antipyretic administration for groups receiving antipyretics. Temperature was recorded at bedtime daily for 3 following days (Day 2 to Day 4) and at any time during the 3 days when fever was suspected. The highest temperature for each day was recorded in the e-diary. Incidences of fever were presented in following categories: >=38 but <=39 degree C, >39 but <=40 degree C and >40 degree C. (NCT01392378)
Timeframe: Within 4 days after infant series Dose 2

,,,,
Interventionpercentage of participants (Number)
Fever >=38, <=39 degree C (n= 141,152,140,159,181)Fever >39, <=40 degree C (n = 133,140,134,145,164)Fever >40 degree C (n = 131,140,133,144,164)
13vPnC + INFANRIX Hexa39.83.70.0
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily44.01.40.0
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily42.80.70.0
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily21.41.50.0
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily26.21.50.0

Percentage of Participants Reporting Fever Within 4 Days: Infant Series Dose 3

Participants' rectal temperature was collected for 4 days after each vaccination using an electronic diary. Participants' temperature was collected at 6 to 8 hours after vaccination, 6 to 8 hours following that and coincidentally with antipyretic administration for groups receiving antipyretics. Temperature was recorded at bedtime daily for 3 following days (Day 2 to Day 4) and at any time during the 3 days when fever was suspected. The highest temperature for each day was recorded in the e-diary. Incidences of fever were presented in following categories: >=38 but <=39 degree C, >39 but <=40 degree C and >40 degree C. Report of fever >40 degrees C after 13vPnC Infant Series Dose 3 was confirmed as data entry error. (NCT01392378)
Timeframe: Within 4 days after infant series Dose 3

,,,,
Interventionpercentage of participants (Number)
Fever >=38, <=39 degree C (n= 136,146,135,141,175)Fever >39, <=40 degree C (n = 129,137,125,136,167)Fever >40 degree C (n = 128,136,126,135,166)
13vPnC + INFANRIX Hexa29.71.80.0
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily33.31.50.0
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily30.82.90.0
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily17.00.80.8
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily22.11.60.0

Percentage of Participants Reporting Fever Within 4 Days: Toddler Dose

Participants' rectal temperature was collected for 4 days after each vaccination using an electronic diary. Participants' temperature was collected at 6 to 8 hours after vaccination, 6 to 8 hours following that and coincidentally with antipyretic administration for groups receiving antipyretics. Temperature was recorded at bedtime daily for 3 following days (Day 2 to Day 4) and at any time during the 3 days when fever was suspected. The highest temperature for each day was recorded in the e-diary. Incidences of fever were presented in following categories: >=38 but <=39 degree C, >39 but <=40 degree C and >40 degree C. (NCT01392378)
Timeframe: Within 4 days after toddler dose

,,,,
Interventionpercentage of participants (Number)
Fever >=38, <=39 degree C (n= 133,140,134,144,162)Fever >39, <=40 degree C (n = 128,127,118,123,150)Fever >40 degree C (n = 123,125,117,122,150)
13vPnC + INFANRIX Hexa30.22.00.0
13vPnC + INFANRIX Hexa + Ibuprofen Thrice Daily50.05.70.0
13vPnC + INFANRIX Hexa + Ibuprofen Twice Daily37.17.10.0
13vPnC + INFANRIX Hexa + Paracetamol Thrice Daily37.34.20.0
13vPnC + INFANRIX Hexa + Paracetamol Twice Daily31.65.50.0

Clinically Significant Hypotension

Clinically significant hypotension is defined as an acute drop in mean arterial pressure requiring treatment. Treatment is defined as either a 500 cc (or greater) fluid bolus and/or an increase in inotrope support of greater than 5 mcg/min over baseline. (NCT02280239)
Timeframe: 4 hours post acetaminophen administration

InterventionParticipants (Count of Participants)
Control Group0
Acetaminophen Group0

Blood Pressure

systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressures (MAP) will be monitored for 4 hours post intervention (NCT02280239)
Timeframe: 4 hours post intervention

,
InterventionmmHg (Mean)
SBP: Pre-Intervention (2 hours)SBP: Post-Intervention (4 hours)DBP: Pre-Intervention (2 hours)DBP: Post-Intervention (4 hours)MAP: Pre-Intervention (2 hours)MAP: Post-Intervention (4 hours)
Acetaminophen Group122.6119.566.265.484.182.4
Control Group141.6141.557.451.080.875.5

Equivalent-dose of Vasoactive Medication Post Intervention

"Total dose of all vasoactive medications will be converted to total Equidose value (with the formula 10 mcg/min norepinephrine ≈ 5 mcg/kg/min dopamine ≈ 10 mcg/min epinephrine ≈ 1 mcg/min phenylephrine ≈ 0.02 u/min vasopressin as per Russell et al. (2008)) before comparing the treatment and control groups~Only 2 of the 6 participants were on low-dose vasoactive medications, (i.e., one was on norepinephrine and the other was on milrinone) therefore the pre-planned conversion calculation was not done." (NCT02280239)
Timeframe: 4 hours post intervention

,
Interventionmcg (Number)
Pre-Intervention (2 hours) TOTAL NorepinephrinePre-Intervention (2 hours) TOTAL MilrinonePost-Intervention (4 hours) TOTAL NorepinephrinePost-Intervention (4 hours) TOTAL Milrinone
Acetaminophen GroupNA6000.0NA7000.0
Control Group167.0NA576.0NA

Equivalent-volume Fluid Administered Post Intervention

Total crystalloid and colloid fluid will be converted the the equi-volume dose (with the ratio 1.4:1 (as per Finfer et al.(2004) & Vincent and Weil (2006) before making comparisons between the treatment and control groups. (NCT02280239)
Timeframe: 4 hours post intervention

,
InterventionmL (Mean)
Pre-Intervention (2 hours) Total fluid INTAKEPre-Intervention (2 hours) Total fluid OUTPUTPost-Intervention (4 hours) Total Fluid INTAKEPost-Intervention (4 hours) Total Fluid OUTPUT
Acetaminophen Group298370612852
Control Group23580734245

Fever Burden

"Continuous measurements of core body temperature will be recorded for 6 hours. Fever burden (FB) is defined as area between the 6 hour temperature curve and 38.3°C cut-off and it is reported in °C-hour.~PRE-INTERVENTION FB: is reported for a 2 hour period. POST-INTERVENTION FB: post-intervention fever burden is reported for a 6 hour period and average hourly fever burden.~Peak Temperature: is the highest recorded temperature for the study period in °C Minimum Temperature: is the lowest recorded temperature for the study period in °C" (NCT02280239)
Timeframe: 6 hours post intervention

,
Intervention°C*hours (Mean)
Pre-Intervention FB (2 hours)Post-Intervention FB (6 hours)
Acetaminophen Group2.165.65
Control Group0.970.74

2-hour Change Over Time Core Temperature

change over time core temperature after study drug administration (adjusted to baseline core temperature) (NCT01869699)
Timeframe: 2 hours

Interventiondegrees Celsius (Mean)
Normal Saline Placebo-0.01
Acetaminophen-0.8

2-hour Change Over Time Heart Rate

2-hour change over time heart rate from time of study drug administration (means adjusted to baseline HR) (NCT01869699)
Timeframe: Baseline to 2 hours

InterventionBPM (Mean)
Normal Saline Placebo2
Acetaminophen-6

2-hour Change Over Time Systolic Blood Pressure

2-hour change over time SBP from study drug administration (means adjusted to baseline SBP) (NCT01869699)
Timeframe: Baseline to 2 hours

Interventionmm Hg (Mean)
Normal Saline Placebo-0.1
Acetaminophen-24

Core Body Temperature

time-weighted average core body temperature over 4 hours. Core temperature was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the core temperature values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Interventiondegrees Celsius (Mean)
Normal Saline Placebo38.4
Acetaminophen37.9

Heart Rate

time-weighted average heart rate over 4 hours. Heart rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the heart rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Interventionbeats per minute (Mean)
Normal Saline Placebo92
Acetaminophen87

Respiratory Rate

time weighted average for respiratory rate over 4 hours. Respiratory rate was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the respiratory rate values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Interventionbreaths per minute (Mean)
Normal Saline Placebo22
Acetaminophen21

Systolic Blood Pressure

time-weighted average systolic blood pressure over 4 hours. Systolic blood pressure was measured every 5 minutes times 4, and then every 15 minutes over the following 4 hours from the time of study drug administration. The sum of the systolic blood pressure values was divided by time in minutes. (NCT01869699)
Timeframe: Baseline to 4 hours post study drug administration

Interventionmm Hg (Mean)
Normal Saline Placebo143
Acetaminophen127

Anti-hepatitis B Surface Antigen (Anti-HBs) Antibody Concentrations

The seroprotection cut-off for the assay was ≥ 10 mIU/mL. (NCT00496015)
Timeframe: 1 month post-vaccination (M1)

InterventionmIU/mL (Geometric Mean)
Synflorix I Group1883.9
Synflorix II Group1460.6
Synflorix PRE Group2133
Synflorix POST Group1818.5
Mencevax + Infanrix Hexa Group20610

Anti-hepatitis B Surface Antigen (Anti-HBs) Antibody Concentrations

The seroprotection cut-off for the assay was ≥ 10 mIU/mL. (NCT00496015)
Timeframe: 12 month post-vaccination (M12)

InterventionmIU/mL (Geometric Mean)
Synflorix I Group219.3
Synflorix II Group147.3
Synflorix PRE Group231.2
Synflorix POST Group139.2
Mencevax + Infanrix Hexa Group535.1

Anti-hepatitis B Surface Antigen (Anti-HBs) Antibody Concentrations in the Mencevax + Infanrix Hexa Group

The seroprotection cut-off for the assay was ≥ 10 milli international units per milliliter (mIU/mL). Results were only tabulated for subjects who received a vaccine including the respective antigens (Mencevax + Infanrix Hexa Group). Dummy lower limit (LL) (0.0) and upper limit UL (99999.9) were entered when number of subjects analysed = 1. (NCT00496015)
Timeframe: Prior to vaccination (Pre)

InterventionmIU/mL (Geometric Mean)
Mencevax + Infanrix Hexa Group1336.1

Anti-polyribosyl-ribitol Phosphate (Anti-PRP) Antibody Concentrations

The seroprotection cut-off for the assay was ≥ 0.15 μg/mL. (NCT00496015)
Timeframe: 1 month post-vaccination (M1)

Interventionμg/mL (Geometric Mean)
Synflorix I Group23.066
Synflorix II Group26.006
Synflorix PRE Group27.373
Synflorix POST Group22.011
Mencevax + Infanrix Hexa Group20.985

Anti-tetanus Toxoids (Anti-T) Antibody Concentrations in the Mencevax + Infanrix Hexa Group

The seroprotection cut-off for the assay was ≥ 0.1 international units per milliliter (IU/mL). (NCT00496015)
Timeframe: Prior to vaccination (Pre)

InterventionIU/mL (Geometric Mean)
Mencevax + Infanrix Hexa Group0.512

Number of Subjects Reported With Core Fever (Rectal Temperature) Greater Than (>) the Cut-off

The cut-off value for core fever (rectal temperature) was 39.0ºC. (NCT00496015)
Timeframe: Within 4 days (Day 0-3) after primary vaccination dose

InterventionParticipants (Count of Participants)
Synflorix I Group4
Synflorix II Group0
Synflorix PRE Group14
Synflorix POST Group1
Mencevax + Infanrix Hexa Group16

Number of Subjects Reported With Core Fever (Rectal Temperature) Greater Than or Equal to (≥) the Cut-off

The cut-off for core fever was 38.0 degrees Celsius (ºC). (NCT00496015)
Timeframe: Within 4 days (Day 0-3) after primary vaccine dose.

InterventionParticipants (Count of Participants)
Synflorix I Group64
Synflorix II Group14
Synflorix PRE Group100
Synflorix POST Group16
Mencevax + Infanrix Hexa Group146

Number of Subjects Reported With Serious Adverse Events (SAEs)

Serious adverse events (SAEs) assessed include medical occurrences that result in death, are life threatening, require hospitalization or prolongation of hospitalization or result in disability/incapacity. (NCT00496015)
Timeframe: Throughout the entire study period (Month 0-Month 12)

InterventionParticipants (Count of Participants)
Synflorix I Group13
Synflorix II Group5
Synflorix PRE Group13
Synflorix POST Group4
Mencevax + Infanrix Hexa Group30

Number of Subjects Reported With Unsolicited Adverse Events (AEs)

"The outcome measure was not reporting statistics for all the arms in the baseline period. Results were tabulated on baseline groups except for the Synforix PRE and Synforix POST groups, for which results were presented for the Pooled Synforix PRE and POST Group.~An unsolicited AE covers any untoward medical occurrence in a clinical investigation subject temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product and reported in addition to those solicited during the clinical study and any solicited symptom with onset outside the specified period of follow-up for solicited symptoms. Any was defined as the occurrence of any unsolicited AE regardless of intensity grade or relation to vaccination." (NCT00496015)
Timeframe: Within 31 days (Days 0-30) after primary vaccine dose.

InterventionParticipants (Count of Participants)
Synflorix I Group22
Synflorix II Group3
Mencevax + Infanrix Hexa Group64
Pooled Synflorix PRE and POST Group30

Anti-pertussis Toxoid (Anti-PT), Anti-filamentous Haemagglutinin (Anti-FHA) and Anti-pertactin (Anti-PRN) Antibody Concentrations

The seropositivity cut-off for the assay was ≥ 5 Enzyme-Linked ImmunoSorbent Assay (ELISA) units per millimiter (EL.U/mL). (NCT00496015)
Timeframe: 1 month post-vaccination (M1)

,,,,
InterventionEL.U/mL (Number)
Anti-PT, M1Anti-FHA, M1Anti-PRN, M1
Mencevax + Infanrix Hexa Group163.1580.8350.7
Synflorix I Group83.3467.9222.8
Synflorix II Group81.6431.1153.4
Synflorix POST Group76.7400.4220.4
Synflorix PRE Group82453.8254.9

Anti-poliovirus (Anti-Polio) Type 1, 2 and 3 Titers

The seroprotection cut-off for the assay was ≥ 8. (NCT00496015)
Timeframe: 12 month post-vaccination (M12)

,,,,
InterventionTiters (Geometric Mean)
Anti-Polio 1, M12Anti-Polio 2, M12Anti-Polio 3, M12
Mencevax + Infanrix Hexa Group335.4322.7203.3
Synflorix I Group208.2311.2431.3
Synflorix II Group150.4212.4301
Synflorix POST Group220.8400672.2
Synflorix PRE Group234.5310.6506.3

Anti-poliovirus (Anti-Polio) Types 1, 2 and 3 Titers

The seroprotection cut-off for the assay was ≥ 8. (NCT00496015)
Timeframe: 1 month post-vaccination (M1)

,,,,
InterventionTiters (Geometric Mean)
Anti-Polio 1, M1Anti-Polio 2, M1Anti-Polio 3, M1
Mencevax + Infanrix Hexa Group409681928192
Synflorix I Group11931354.12354.2
Synflorix II Group1534.22047.92233.3
Synflorix POST Group1208.62215.83576.5
Synflorix PRE Group1058.71413.22647.5

Antibody Concentrations Against Certain Pneumococcal Serotypes ≥ the Cut Off.

"Certain pneumococcal serotypes included pneumococcal serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F (Anti-1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F).~Anti-1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F antibody concentrations were measured by 22F-inhibition Enzyme-Linked ImmunoSorbent Assay (ELISA).~Seropositivity cut-off for the assay was ≥ 0.05 microgram per milliliter (μg/mL)." (NCT00496015)
Timeframe: Prior to booster vaccination (PRE), 1 month (M1) and 12 months (M12) post-booster vaccination

,,,,
Interventionμg/mL (Geometric Mean)
ANTI-1 PREANTI-1 M1ANTI-1 M12ANTI-4 PREANTI-4 M1ANTI-4 M12ANTI-5 PREANTI-5 M1ANTI-5 M12ANTI-6B PREANTI-6B M1ANTI-6B M12ANTI-7F PREANTI-7F M1ANTI-7F M12ANTI-9V PREANTI-9V M1ANTI-9V M12ANTI-14 PREANTI-14 M1ANTI-14 M12ANTI-18C PREANTI-18C M1ANTI-18C M12ANTI-19F PREANTI-19F M1ANTI-19F M12ANTI-23F PREANTI-23F M1ANTI-23F M12
Mencevax + Infanrix Hexa Group0.030.030.040.030.030.040.040.040.060.030.030.040.030.030.040.030.030.040.040.050.110.030.030.040.030.050.120.030.030.04
Synflorix I Group0.221.670.260.43.010.340.362.30.420.351.350.40.742.90.680.612.860.670.824.580.890.474.960.560.9861.460.381.990.46
Synflorix II Group0.181.640.180.242.840.210.3120.350.180.890.360.552.370.450.592.570.550.524.370.940.293.460.440.634.840.820.31.330.29
Synflorix POST Group0.262.970.410.453.950.550.533.030.580.52.250.540.874.380.960.994.350.861.275.861.250.546.130.921.48.772.040.453.860.98
Synflorix PRE Group0.312.620.390.64.210.50.593.680.720.552.450.561.054.130.9114.390.971.575.951.540.7871.051.487.551.80.542.920.8

Antibody Concentrations Against Pneumococcal Serotypes 6A and 19A (Anti-6A and 19A)

Anti-6A and 19A antibody concentrations were measured by 22F-inhibition Enzyme-Linked ImmunoSorbent Assay (ELISA). (NCT00496015)
Timeframe: Prior to booster vaccination (PRE), 1 month (M1) and 12 months (M12) post-booster vaccination

,,,,
Interventionμg/mL (Geometric Mean)
Anti-6A-PREAnti-6A-M1Anti-6A-M12Anti-19A-PREAnti-19A-M1Anti-19A-M12
Mencevax + Infanrix Hexa Group0.030.030.040.030.040.06
Synflorix I Group0.120.40.140.150.840.22
Synflorix II Group0.080.290.10.120.560.13
Synflorix POST Group0.190.750.20.21.540.41
Synflorix PRE Group0.210.860.240.231.340.36

Concentrations of Antibodies Against Diphtheria and Tetanus Toxoids (Anti-D and T).

The seroprotection cut-off for the assay was ≥ 0.1 international units per milliliter (IU/mL). (NCT00496015)
Timeframe: 1 month post-vaccination (M1)

,,,,
InterventionIU/mL (Geometric Mean)
Anti-D, M1Anti-T, M1
Mencevax + Infanrix Hexa Group7.29111.79
Synflorix I Group10.1127.382
Synflorix II Group9.8398.684
Synflorix POST Group118.196
Synflorix PRE Group12.2859.583

Concentrations of Antibodies Against Protein D (Anti-PD)

The seropositivity cut-off for the assay was ≥ 100 Enzyme-Linked ImmunoSorbent Assay (ELISA) units per milliliter (EL.U/mL). (NCT00496015)
Timeframe: Prior to booster vaccination (PRE), 1 month (M1) and 12 months (M12) post-booster vaccination

,,,,
InterventionEL.U/mL (Geometric Mean)
Anti-PD-PREAnti-PD-M1Anti-PD-M12
Mencevax + Infanrix Hexa Group65.664.674.4
Synflorix I Group365.11654468.1
Synflorix II Group356.51813.5418
Synflorix POST Group584.32612.3713.4
Synflorix PRE Group685.53134.2834.6

Geometric Mean Antibody Concentration (GMCs) for Anti-polysaccharide N (Anti-PS) Antibody Concentrations

Anti-PS assessed were Anti-PSA, anti-PSC, anti-PSW-135 and anti-PSY. Results were only tabulated for subjects who received a vaccine including the respective antigens (Mencevax + Infanrix Hexa Group). (NCT00496015)
Timeframe: Prior to vaccination(PRE), 1 month (M1) and 12 months (M12) post- vaccination.

Interventionμg/mL (Geometric Mean)
Anti-PSA, PreAnti-PSA, M1Anti-PSA, M12Anti-PSC, PreAnti-PSC, M1Anti-PSC, M12Anti-PSW-135, PreAnti-PSW-135, M1Anti-PSW-135, M12Anti-PSY, PreAnti-PSY, M1Anti-PSY, M12
Mencevax + Infanrix Hexa Group0.1636.280.990.1514.120.420.156.111.210.158.031.81

Number of Nasopharyngeal Swabs With H. Influenzae

Results were tabulated on Mencevax + Infanrix Hexa Group and on Pooled Synflorix Group. (NCT00496015)
Timeframe: Prior to vaccination(Pre), 1 month post-vaccination (M1), 3 months post-vaccination (M3), 7 months post-vaccination (M7), 12 months post-vaccination (M12) and across all time points (Overall)

,
InterventionSwabs (Number)
PreM1M3M7M12Overall
Mencevax + Infanrix Hexa Group4139344957124
Pooled Synflorix Group4856626446160

Number of Nasopharyngeal Swabs With S. Pneumoniae and H. Influenzae

Results were tabulated on Mencevax + Infanrix Hexa Group and on Pooled Synflorix Group. (NCT00496015)
Timeframe: Prior to vaccination(Pre), 1 month post-vaccination (M1), 3 months post-vaccination (M3), 7 months post-vaccination (M7), 12 months post-vaccination (M12) and across all time points (Overall)

,
InterventionSwabs (Number)
PreM1M3M7M12Overall
Mencevax + Infanrix Hexa Group192017222261
Pooled Synflorix Group213031281986

Number of Nasopharyngeal Swabs With S.Pneumoniae (Cross-reactive Serotypes)

Results were tabulated on Pooled Synflorix Group and on Mencevax + Infanrix Hexa Group. (NCT00496015)
Timeframe: Prior to vaccination(Pre), 1 month post-vaccination (M1), 3 months post-vaccination (M3), 7 months post-vaccination (M7), 12 months post-vaccination (M12) and across all time points (Overall)

,
InterventionSwabs (Number)
PreM1M3M7M12Overall
Mencevax + Infanrix Hexa Group131921191955
Pooled Synflorix Group152227211859

Number of Nasopharyngeal Swabs With S.Pneumoniae (Non-vaccine and Non-cross-reactive Serotypes)

Results were tabulated on Mencevax + Infanrix Hexa Group and on Pooled Synflorix Group. (NCT00496015)
Timeframe: Prior to vaccination(Pre), 1 month post-vaccination (M1), 3 months post-vaccination (M3), 7 months post-vaccination (M7), 12 months post-vaccination (M12) and across all time points (Overall)

,
InterventionSwabs (Number)
PreM1M3M7M12Overall
Mencevax + Infanrix Hexa Group263032292282
Pooled Synflorix Group2742454239111

Number of Nasopharyngeal Swabs With S.Pneumoniae (Vaccine Serotypes)

Results were tabulated on Pooled Synflorix Group and on Mencevax + Infanrix Hexa Group. (NCT00496015)
Timeframe: Prior to vaccination(Pre), 1 month post-vaccination (M1), 3 months post-vaccination (M3), 7 months post-vaccination (M7), 12 months post-vaccination (M12) and across all time points (Overall)

,
InterventionSwabs (Number)
PreM1M3M7M12Overall
Mencevax + Infanrix Hexa Group5347555043115
Pooled Synflorix Group4345494234111

Number of Subjects Reported With AEs Resulting in Rash, New Onset of Chronic Illness (NOCI), Emergency Room (ER) Visits and Non-routine Physician Office Visits.

Results were tabulated only on Mencevax + Infanrix Hexa Group, according to the outcome measure specification of the protocol. (NCT00496015)
Timeframe: Up to 6 months after vaccination with Mencevax™

InterventionParticipants (Count of Participants)
Subject(s) with any rash(es)Subject(s) with any NOCI(s)Subject(s) with any ER visit(s)Subject(s) with any visit(s) at physician office
Mencevax + Infanrix Hexa Group71053

Number of Subjects Reported With Any and Grade 3 Solicited Local Symptoms.

Solicited local symptoms assessed were pain, redness and swelling. Any was defined as any occurrence of the specified symptom regardless of intensity. Grade 3 pain was defined as cried when limb was moved/spontaneously painful. Grade 3 redness/swelling was defined as redness/swelling > 30 millimeters (mm) from injection site. (NCT00496015)
Timeframe: During the 4-day (Days 0-3) post-primary vaccination period

,,,,
InterventionParticipants (Count of Participants)
Any PainGrade 3 PainAny RednessGrade 3 RednessAny SwellingGrade 3 Swelling
Mencevax + Infanrix Hexa Group1144146167112
Synflorix I Group542897522
Synflorix II Group1029181
Synflorix POST Group193121133
Synflorix PRE Group79107414509

Number of Subjects Reported With Any, Grade 3 and Related Solicited General Symptoms

Solicited general symptoms assessed were drowsiness, fever (rectal temperature ≥ 38.5°C), irritability and loss of appetite. Any was defined as any occurrence of the specified symptom regardless of intensity and relation to vaccination. Grade 3 drowsiness was defined as drowsiness that prevented normal activity. Grade 3 fever was defined as rectal temperature >40.0°C. Grade 3 irritability was defined as crying that could not be comforted/ prevented normal activity. Grade 3 loss of appetite was defined as not eating at all. Related was defined as solicited symptoms assessed by the investigator as causally related to the study vaccination. (NCT00496015)
Timeframe: During the 4-day (Day 0-3) post-vaccination period

,,,,
InterventionParticipants (Count of Participants)
Any DrowsinessGrade 3 DrowsinessRelated DrowsinessAny Fever (rectal temperature ≥ 38.0°C)Grade 3 Fever (rectal temperature > 40.0°C)Related Fever (rectal temperature > 40.0°C)Any IrritabilityGrade 3 IrritabilityRelated IrritabilityAny Loss of appetiteGrade 3 Loss of appetiteRelated Loss of appetite
Mencevax + Infanrix Hexa Group14621201463140147212988371
Synflorix I Group91084641628618047042
Synflorix II Group110111401417017807
Synflorix POST Group18118160161921810110
Synflorix PRE Group8417910019910529846441

Number of Subjects With Anti-polysaccharide N (Anti-PS) Concentrations ≥ the Cut-off Values

Anti-PS assessed were anti-PS meningitidis serogroup A (anti-PSA), C (anti-PSC), W (anti-PSW-135) and Y (anti-PSY). The cut-offs for anti-PS concentrations were 0.3 μg/mL and 2.0 μg/mL, tabulated for subjects who received a vaccine including the respective antigens (Mencevax + Infanrix Hexa Group). (NCT00496015)
Timeframe: Prior to vaccination(PRE), 1 month (M1) and 12 months (M12) post-vaccination

InterventionParticipants (Count of Participants)
ANTI-PSA PRE ≥ 0.3 μg/mLANTI-PSA PRE ≥ 2.0 μg/mLANTI-PSA M1≥ 0.3 μg/mLANTI-PSA M1 ≥ 2.0 μg/mLANTI-PSA M12 ≥ 0.3 μg/mLANTI-PSA M12 ≥ 2.0 μg/mLANTI-PSC PRE ≥ 0.3 μg/mLANTI-PSC PRE ≥ 2.0 μg/mLANTI-PSC M1 ≥ 0.3 μg/mLANTI-PSC M1≥ 2.0 μg/mLANTI-PSC M12 ≥ 0.3 μg/mLANTI-PSC M12 ≥ 2.0 μg/mLANTI-PSW-135 PRE ≥ 0.3 μg/mLANTI-PSW-135 PRE ≥ 2.0 μg/mLANTI-PSW-135 M1 ≥ 0.3 μg/mLANTI-PSW-135 M1 ≥ 2.0 μg/mLANTI-PSW-135 M12 ≥ 0.3 μg/mLANTI-PSW-135 M12 ≥ 2.0 μg/mLANTI-PSY PRE ≥ 0.3 μg/mLANTI-PSY PRE ≥ 2.0 μg/mLANTI-PSY M1 ≥ 0.3 μg/mLANTI-PSY M1 ≥ 2.0 μg/mLANTI-PSY M12 ≥ 0.3 μg/mLANTI-PSY M12 ≥ 2.0 μg/mL
Mencevax + Infanrix Hexa Group121271271133473027827794910258234117453026124913159

Number of Subjects With Antibody Concentrations Against Certain Pneumococcal Serotypes ≥ the Cut Off

"Certain pneumococcal serotypes includes pneumococcal serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F (Anti-1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F). Anti-1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F antibody concentrations were measured by 22F-inhibition Enzyme-Linked ImmunoSorbent Assay (ELISA).~The seroprotection cut-off for the assay was ≥ 0.2 microgram per milliliter (μg/mL)." (NCT00496015)
Timeframe: Prior to booster vaccination (PRE), 1 month (M1) and 12 months (M12) post-booster vaccination

,,,,
InterventionParticipants (Count of Participants)
ANTI-1 PREANTI-1 M1ANTI-1 M12ANTI-4 PREANTI-4 M1ANTI-4 M12ANTI-5 PREANTI-5 M1ANTI-5 M12ANTI-6B PREANTI-6B M1ANTI-6B M12ANTI-7F PREANTI-7F M1ANTI-7F M12ANTI-9V PREANTI-9V M1ANTI-9V M12ANTI-14 PREANTI-14 M1ANTI-14 M12ANTI-18C PREANTI-18C M1ANTI-18C M12ANTI-19F PREANTI-19F M1ANTI-19F M12ANTI-23F PREANTI-23F M1ANTI-23F M12
Mencevax + Infanrix Hexa Group6511662061031112159205103025296389291724902424
Synflorix I Group741408912314110310214011311013497130140132117141129131140131118141113128138135103135115
Synflorix II Group142411152414152318132118212521202420222421142518212522142116
Synflorix POST Group273630313727303630323530343736343735353634293735363736303633
Synflorix PRE Group115167122147167147142167159143166148156167165152167166159166166154167157163165165132163154

Number of Subjects With New Acquisition Associated to H. Influentzae Detected in Nasopharyngeal Swabs.

Results were tabulated on Mencevax + Infanrix Hexa Group and on Pooled Synflorix Group. (NCT00496015)
Timeframe: 1 month post-vaccination (M1), 3 months post-vaccination (M3), 7 months post-vaccination (M7), 12 months post-vaccination (M12) and across all time points (Overall)

,
InterventionParticipants (Count of Participants)
M1M3M7M12Overall
Mencevax + Infanrix Hexa Group21223739104
Pooled Synflorix Group32404235129

Number of Subjects With New Acquisition Associated to S. Pneumoniae Detected in Nasopharyngeal Swabs

Results were tabulated on Mencevax + Infanrix Hexa Group and on Pooled Synflorix Group. (NCT00496015)
Timeframe: 1 month post-vaccination (M1), 3 months post-vaccination (M3), 7 months post-vaccination (M7), 12 months post-vaccination (M12) and across all time points (Overall)

,
InterventionParticipants (Count of Participants)
M1M3M7M12Overall
Mencevax + Infanrix Hexa Group43637065161
Pooled Synflorix Group56767370195

Number of Subjects With Serum Bactericidal Antibodies, Using Baby Rabbit Complement for Assay (rSBA) Titres ≥ the Cut-off Values

"The cut-off values assessed were 1:8 and 1:128 for meningococcal polysaccharides A , C, W-135 and Y serum bactericidal antibodies, using baby rabbit complement for assay (rSBA-MenA, rSBA-MenC, rSBA-MenW-135 and rSBA-MenY).~Results were only tabulated for subjects who received a vaccine including the respective antigens (Mencevax + Infanrix Hexa Group)." (NCT00496015)
Timeframe: Prior to vaccination (PRE), 1 month (M1) and 12 months (M12) post-vaccination

InterventionParticipants (Count of Participants)
rSBA-MenA,Pre, ≥ 1:8rSBA-MenA, Pre, ≥ 1:128rSBA-MenA, M1, ≥ 1:8rSBA-MenA, M1, ≥ 1:128rSBA-MenA, M12, ≥ 1:8rSBA-MenA, M12, ≥ 1:128rSBA-MenC,Pre, ≥ 1:8rSBA-MenC, Pre, ≥ 1:128rSBA-MenC, M1, ≥ 1:8rSBA-MenC, M1, ≥ 1:128rSBA-MenC, M12, ≥ 1:8rSBA-MenC, M12, ≥ 1:128rSBA-MenW-135,Pre, ≥ 1:8rSBA-MenW-135, Pre, ≥ 1:128rSBA-MenW-135, M1, ≥ 1:8rSBA-MenW-135, M1, ≥ 1:128rSBA-MenW-135, M12, ≥ 1:8rSBA-MenW-135, M12, ≥ 1:128rSBA-MenY,Pre, ≥ 1:8rSBA-MenY, Pre, ≥ 1:128rSBA-MenY, M1, ≥ 1:8rSBA-MenY, M1, ≥ 1:128rSBA-MenY, M12, ≥ 1:8rSBA-MenY, M12, ≥ 1:128
Mencevax + Infanrix Hexa Group694429829813613450173002941541051145930130113812916793300300137127

Opsonophagocytic Activity (OPA) Titers Against Pneumococcal Cross-reactive Serotypes 6A and 19A

OPA titers against pneumococcal serotypes 6A and 19A (Opsono-6A and 19A) were calculated, expressed as geometric mean titers (GMTs) and tabulated. The seropositivity cut-off for the assay was ≥ 8. (NCT00496015)
Timeframe: Prior to booster vaccination (PRE), 1 month (M1) and 12 months (M12) post-booster vaccination

,,,,
InterventionTiters (Geometric Mean)
OPSONO-6A-PREOPSONO-6A-M1OPSONO-6A-M12OPSONO-19A-PREOPSONO-19A-M1OPSONO-19A-M12
Mencevax + Infanrix Hexa Group9.716.117.1444.7
Synflorix I Group72.4251.559.4539.27
Synflorix II Group35.6105.1234.939.74.8
Synflorix POST Group66403.737.2599.69.5
Synflorix PRE Group65.4401.752.14.889.78.9

Opsonophagocytic Activity (OPA) Titers Against Pneumococcal Serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F

OPA titers against pneumococcal serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F (Opsono-1, -4, -5, -6B, -7F, -9V, -14, -18C, -19F and -23F) were calculated, expressed as geometric mean titers (GMTs) and tabulated. The seropositivity cut-off for the assay was ≥ 8. (NCT00496015)
Timeframe: Prior to booster vaccination (PRE), 1 month (M1) and 12 months (M12) post-booster vaccination

,,,,
InterventionTiters (Geometric Mean)
OPSONO-1 PREOPSONO-1 M1OPSONO-1 M12OPSONO-4 PREOPSONO-4 M1OPSONO-4 M12OPSONO-5 PREOPSONO-5 M1OPSONO-5 M12OPSONO-6B PREOPSONO-6B M1OPSONO-6B M12OPSONO-7F PREOPSONO-7F M1OPSONO-7F M12OPSONO-9V PREOPSONO-9V M1OPSONO-9V M12OPSONO-14 PREOPSONO-14 M1OPSONO-14 M12OPSONO-18C PREOPSONO-18C M1OPSONO-18C M12OPSONO-19F PREOPSONO-19F M1OPSONO-19F M12OPSONO-23F PREOPSONO-23F M1OPSONO-23F M12
Mencevax + Infanrix Hexa Group4.95.14.75.97.86.84.24.349.920.919.190267.3681.169.287.4127.211.5158287.84.544.65.34.56.420.2261.8147.1
Synflorix I Group6.1144.612.823.81547.919.98.5134.310.332.5496.746.9413.64025.81503.3420.72234.8791.6189.71581.7434.56.1652.911.921.2629.464.3288.72335.7386.4
Synflorix II Group5.6193.412.58.8971.614.910.410510.515.9148.397.7221.417491606.4472.9752.9552.2150.21515438.46269.724.717.4372.939.4310.11223.1433.8
Synflorix POST Group632520.529.71303.272.515.1227.715.449.7718.329.4258.42212.21738.3365.71155.5716.8227.41964.55589.5537.623.536.41198.8121.3305.31808.7670.2
Synflorix PRE Group8.141723.144.9229751.216.6289.323.745.2985.753.9584.74674.71285.7407.72403.7906.7293.21865.2447.511.7737.827.735.11062.2101.34083154857.5

rSBA-MenA, rSBA-MenC, rSBA-MenW-135 and rSBA-MenY Titers in the Mencevax + Infanrix Hexa Group

Results were only tabulated for subjects who received a vaccine including the respective antigens (Mencevax + Infanrix Hexa Group). (NCT00496015)
Timeframe: Prior to vaccination(PRE), 1 month (M1) and 12 months (M12) post- vaccination.

InterventionTiters (Geometric Mean)
rSBA-MenA,PrerSBA-MenA, M1rSBA-MenA, M12rSBA-MenC,PrerSBA-MenC, M1rSBA-MenC, M12rSBA-MenW-135,PrerSBA-MenW-135, M1rSBA-MenW-135, M12rSBA-MenY,PrerSBA-MenY, M1rSBA-MenY, M12
Mencevax + Infanrix Hexa Group11.52151.3677.66.9811.2191.116.35393.6573.130.22863.7665.2

Fold-difference in Geometric Mean Serum Hemagglutination-inhibition (HAI) Antibody Titers, Non-Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intradermal - Influenza B

The fold-difference (defined as a ratio to describe the change from baseline to Day 28) in geometric mean serum HAI antibody titers against influenza B between non-AD and moderate to severe AD participants, following a single dose of the seasonal 2012-2013 Fluzone Intradermal vaccine. A fold-difference of greater than 1 indicated an increase in HAI antibody titers against influenza B as a result of vaccination; therefore, higher numbers indicate a greater probability of avoiding disease if infected with influenza B. Participants who achieved seroprotection (which is defined as having a sufficient antibody amount to avoid disease in half of the individuals infected with influenza B) prior to vaccination were excluded from the analysis. (NCT01737710)
Timeframe: Day 28 post vaccination

InterventionHAI antibody titers (Geometric Mean)
Moderate to Severe AD, Intradermal2.6
Non-AD, Intradermal2.0

Fold-difference in Geometric Mean Serum Hemagglutination-inhibition (HAI) Antibody Titers, Non-Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intradermal - Influenza H1N1

The fold-difference (defined as a ratio to describe the change from baseline to Day 28) in geometric mean serum HAI antibody titers against influenza H1N1 between non-AD and moderate to severe AD participants, following a single dose of the seasonal 2012-2013 Fluzone Intradermal vaccine. A fold-difference of greater than or equal to 1 indicated an increase in HAI antibody titers against influenza H1N1 as a result of vaccination; therefore, higher numbers indicate a greater probability of avoiding disease if infected with influenza H1N1. Participants who achieved seroprotection prior to vaccination were excluded from the analysis, which is defined as having a sufficient antibody amount to avoid disease in half of the individuals infected with influenza H1N1. (NCT01737710)
Timeframe: Day 28 post vaccination

InterventionHAI antibody titers (Geometric Mean)
Moderate to Severe AD, Intradermal22.4
Non-AD, Intradermal37.7

Fold-difference in Geometric Mean Serum Hemagglutination-inhibition (HAI) Antibody Titers, Non-Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intradermal - Influenza H3N2

The fold-difference (defined as a ratio to describe the change from baseline to Day 28) in geometric mean serum HAI antibody titers against influenza H3N2 between non-AD and moderate to severe AD participants, following a single dose of the seasonal 2012-2013 Fluzone Intradermal vaccine. A fold-difference of greater than or equal to 1 indicated an increase in HAI antibody titers against influenza H3N2 as a result of vaccination; therefore, higher numbers indicate a greater probability of avoiding disease if infected with influenza H3N2 Participants who achieved seroprotection prior to vaccination were excluded from the analysis, which is defined as having a sufficient antibody amount to avoid disease in half of the individuals infected with influenza H3N2. (NCT01737710)
Timeframe: Day 28 post vaccination

InterventionHAI antibody titers (Geometric Mean)
Moderate to Severe AD, Intradermal10.1
Non-AD, Intradermal9.7

Seroconversion, Moderate to Severe Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intramuscular - Influenza B

The difference in the percentage of moderate to severe AD participants that achieved seroconversion at Day 28 between those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine and those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone (Intramuscular) vaccine. Seroconversion is defined as a 4-fold or greater increase in serum hemagglutination-inhibition [HAI] antibody titers against influenza B compared to baseline values, which represents the minimum intended effect of vaccination. Participants who achieved seroprotection, defined as having a sufficient antibody amount to avoid disease in half of the individuals infected with influenza B, prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percentage of participants who achieved seroconversion at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 Post Vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal40.6
Moderate to Severe AD, Intramuscular47.8

Seroconversion, Moderate to Severe Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intramuscular - Influenza H1N1

The difference in the percentage of moderate to severe AD participants that achieved seroconversion at Day 28 between those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine and those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone (Intramuscular) vaccine. Seroconversion is defined as a 4-fold or greater increase in serum hemagglutination-inhibition [HAI] antibody titers against influenza H1N1 compared to baseline values, which represents the minimum intended effect of vaccination. Participants who achieved seroprotection, defined as having a sufficient antibody amount to avoid disease in half of the individuals infected with influenza H1N1, prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percentage of participants who achieved seroconversion at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 Post Vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal85.7
Moderate to Severe AD, Intramuscular88.7

Seroconversion, Moderate to Severe Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intramuscular - Influenza H3N2

The difference in the percentage of moderate to severe AD participants that achieved seroconversion at Day 28 between those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine and those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone (Intramuscular) vaccine. Seroconversion is defined as a 4-fold or greater increase in serum hemagglutination-inhibition [HAI] antibody titers against influenza H3N2 compared to baseline values, which represents the minimum intended effect of vaccination. Participants who achieved seroprotection, defined as having a sufficient antibody amount to avoid disease in half of the individuals infected with influenza H3N2, prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percentage of participants who achieved seroconversion at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 Post Vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal76.3
Moderate to Severe AD, Intramuscular87.8

Seroconversion, Non-Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe AD, Intradermal - Influenza H1N1

The difference in the percentage of participants that achieved seroconversion at Day 28 between non-AD and moderate to severe AD participants, following a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine. Seroconversion is defined as a 4-fold or greater increase in serum hemagglutination-inhibition [HAI] antibody titers against influenza H1N1 compared to baseline values, which represents the minimum intended effect of vaccination. Participants who achieved seroprotection, defined as having a sufficient antibody amount to avoid disease in half of the individuals infected with influenza H1N1, prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percentage of participants who achieved seroconversion at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 Post Vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal85.7
Non-AD, Intradermal88.1

Seroconversion, Non-Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intradermal - Influenza B

The difference in the percentage of participants that achieved seroconversion at Day 28 between non-AD and moderate to severe AD participants, following a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine. Seroconversion is defined as a 4-fold or greater increase in serum hemagglutination-inhibition [HAI] antibody titers against influenza B compared to baseline values, which represents the minimum intended effect of vaccination. Participants who achieved seroprotection, defined as having a sufficient antibody amount to avoid disease in half of the individuals infected with influenza B, prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percentage of participants who achieved seroconversion at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 Post Vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal40.6
Non-AD, Intradermal30.4

Seroconversion, Non-Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intradermal - Influenza H3N2

The difference in the percentage of participants that achieved seroconversion at Day 28 between non-AD and moderate to severe AD participants, following a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine. Seroconversion is defined as a 4-fold or greater increase in serum hemagglutination-inhibition [HAI] antibody titers against influenza H3N2 compared to baseline values, which represents the minimum intended effect of vaccination. Participants who achieved seroprotection, defined as having a sufficient antibody amount to avoid disease in half of the individuals infected with influenza H3N2, prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percentage of participants who achieved seroconversion at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 Post Vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal76.3
Non-AD, Intradermal73.3

Seroprotection, Moderate to Severe Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intramuscular - Influenza B

The difference in the percentage of moderate to severe AD participants that achieved seroprotection against influenza B at Day 28 between those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine and those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone (Intramuscular) vaccine. Seroprotection is defined as having a serum hemagglutination-inhibition (HAI) antibody titer of 1:40 or greater, which represents a sufficient antibody amount to avoid disease in half of the individuals infected with influenza B. Participants who achieved seroprotection prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percentage of participants who achieved seroprotection at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 post vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal34.4
Moderate to Severe AD, Intramuscular33.7

Seroprotection, Moderate to Severe Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intramuscular - Influenza H1N1

The difference in the percentage of moderate to severe AD participants that achieved seroprotection against influenza H1N1 at Day 28 between those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine and those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone (Intramuscular) vaccine. Seroprotection is defined as having a serum hemagglutination-inhibition (HAI) antibody titer of 1:40 or greater, which represents a sufficient antibody amount to avoid disease in half of the individuals infected with influenza H1N1. Participants who achieved seroprotection prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percentage of participants who achieved seroprotection at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 Post Vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal84.1
Moderate to Severe AD, Intramuscular92.5

Seroprotection, Moderate to Severe Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intramuscular - Influenza H3N2

The difference in the percentage of moderate to severe AD participants that achieved seroprotection against influenza H3N2 at Day 28 between those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine and those given a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone (Intramuscular) vaccine. Seroprotection is defined as having a serum hemagglutination-inhibition (HAI) antibody titer of 1:40 or greater, which represents a sufficient antibody amount to avoid disease in half of the individuals infected with influenza H3N2. Participants who achieved seroprotection prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percentage of participants who achieved seroprotection at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 Post Vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal84.7
Moderate to Severe AD, Intramuscular93.9

Seroprotection, Non-Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intradermal - Influenza B

The difference in the percent of participants that achieved seroprotection against influenza B at Day 28 between non-AD and moderate to severe AD participants, following a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine. Seroprotection is defined as having a serum hemagglutination-inhibition (HAI) antibody titer of 1:40 or greater, which represents a sufficient antibody amount to avoid disease in half of the individuals infected with influenza B. Participants who achieved seroprotection prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percent of participants who achieved seroprotection at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 post vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal34.4
Non-AD, Intradermal22.5

Seroprotection, Non-Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intradermal - Influenza H1N1

The difference in the percentage of participants that achieved seroprotection against influenza H1N1 at Day 28 between non-AD and moderate to severe AD participants, following a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine. Seroprotection is defined as having a serum hemagglutination-inhibition (HAI) antibody titer of 1:40 or greater, which represents a sufficient antibody amount to avoid disease in half of the individuals infected with influenza H1N1. Participants who achieved seroprotection prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percentage of participants who achieved seroprotection at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 Post Vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal84.1
Non-AD, Intradermal86.4

Seroprotection, Non-Atopic Dermatitis (AD), Intradermal vs. Moderate to Severe Atopic Dermatitis, Intradermal - Influenza H3N2

The difference in the percentage of participants that achieved seroprotection against influenza H3N2 at Day 28 between non-AD and moderate to severe AD participants, following a single dose (0.1mL) of the seasonal 2012 - 2013 Fluzone Intradermal vaccine. Seroprotection is defined as having a serum hemagglutination-inhibition (HAI) antibody titer of 1:40 or greater, which represents a sufficient antibody amount to avoid disease in half of the individuals infected with influenza H3N2. Participants who achieved seroprotection prior to vaccination were excluded from the analysis. The goal was to examine whether there was a difference between the two groups in the percentage of participants who achieved seroprotection at Day 28 who were not seroprotected prior to vaccination. (NCT01737710)
Timeframe: Day 28 Post Vaccination

Interventionpercentage of participants (Number)
Moderate to Severe AD, Intradermal84.7
Non-AD, Intradermal73.3

Child Temperature (Degrees C)Over 6 Hours

Temperature was measured hourly using a temporal thermometer to monitor the child's temperature in degrees C. Temperature of 38 degrees C or higher was considered febrile. (NCT00267293)
Timeframe: 6 hours

Interventiondegrees Celcius (Mean)
Group A: Ibuprofen Alone38.5
Group B: Ibuprofen and Acetaminophen37.2
Group C: Ibuprofen Then Acetaminophen36.9

Fever >=38C Within 32 Hours of Vaccination.

Fever, defined as rectal temperature >=38C within 32 hours of vaccination. (NCT00325819)
Timeframe: Fever within 32 hours following vaccination

Interventionpercentage of participants (Number)
Acetaminophen14
Placebo22

Fever >=39C Within 32 Hours of Vaccination.

Fever, defined as rectal temperature >=39C within 32 hours of vaccination. (NCT00325819)
Timeframe: Fever within 32 hours following vaccination

Interventionpercentage of participants (Number)
Acetaminophen0
Placebo2

Medical Utilization

Telephone calls to the consulting nurse or the child's physician that were made due to concerns regarding an acute illness, fever, or possible vaccine reaction and outpatient, urgent care, and emergency room visits that were for evaluation of an acute illness, fever, or a possible vaccine reaction, within 32 hours of vaccination. (NCT00325819)
Timeframe: Within 32 hours of vaccination.

Interventionpercentage of participants (Number)
Acetaminophen3
Placebo6

Parent Time Lost From Work

Parents were asked to report whether they were scheduled to work on the day of the vaccination visit (but following that visit) or the next day and, if so, whether they had to miss work to care for their infant because of fever, fussiness, or possible vaccine reaction on those days. (NCT00325819)
Timeframe: Through the day after vaccination

Interventionpercentage of participants (Number)
Acetaminophen4
Placebo1

Study Assignment Unblinded

The need for unblinding at any time during the study (NCT00325819)
Timeframe: At any time during participation in the study

Interventionpercentage of participants (Number)
Acetaminophen3
Placebo9

Infant Fussiness

Parents were asked to record level of fussiness (compared with the child's usual) within 32 hours of vaccination, using the categories much less than usual, less than usual, about usual, more than usual, and much more than usual. (NCT00325819)
Timeframe: Within 32 hours of vaccination

,
Interventionpercentage of participants (Number)
Infant fussiness - About usual or less than usualInfant fussiness-More than or much more than usualInfant fussiness-Much more than usual
Acetaminophen425810
Placebo386224

Infant Time Lost From Sleep

Parents were asked about their infant's sleep on the night following the vaccinations. They were asked to report whether their infant slept much less than usual, less than usual, about the usual amount, more than usual, or much more than usual on that night. (NCT00325819)
Timeframe: On the night following vaccinations

,
Interventionpercentage of participants (Number)
Infant sleep - About usual or more than usualInfant sleep - Less than or much less than usualInfant sleep - Much less than usual
Acetaminophen78222
Placebo81192

Parent Time Lost From Sleep

Parents were asked about their sleep on the night following the vaccinations. They were asked to report whether they slept much less than usual, less than usual, about the usual amount, more than usual, or much more than usual on that night. (NCT00325819)
Timeframe: On the night following vaccinations

,
Interventionpercentage of participants (Number)
Parent sleep - About usual or more than usualParent sleep - Less than or much less than usualParent sleep - Much less than usual
Acetaminophen73273
Placebo77235

Number of Participants With Level 3 Postoperative Hemorrhage

Postoperative hemorrhage is defined as any history of bleeding occurring within the 14 day postoperative period. Hemorrhage will be stratified into 3 levels of severity. Level 1: includes children with a history of postoperative bleeding evaluated and/or treated by a physician in the emergency room, inpatient unit or operating room; Level 2: children requiring inpatient admission for postoperative bleeding regardless of the need for operative intervention; Level 3: children requiring inpatient admission and return to the operating room for control of post-tonsillectomy hemorrhage. (NCT01605903)
Timeframe: Data about post-tonsillectomy bleeding will be obtained after the end of a 14-day postoperative period.

InterventionParticipants (Count of Participants)
Treatment With Ibuprofen10
Treatment With Acetaminophen4

Faces Pain Score

Using the Faces Pain Scale, the pediatric patient will indicate his/her pain level at scheduled intervals (7 times per day) for 14 days post-surgery.The Faces Pain Scale Revised is a dimensionless 10 point likert scale used to assess self-reported pain intensity on a scale from 0 (no pain) to 10 (most pain you can imagine). Greater pain scores are indicative of more severe pain. For this analysis, participant pain scores were summed and the mean per group was calculated. Total summed scores could range from 0 to 980. (NCT02296840)
Timeframe: 2 weeks after surgery

Interventionunits on a scale (Mean)
Ibuprofen158.95
Hydrocodone-acetaminophen219.94

Number of Participants With Post-operative Bleeding

The occurrence of post-operative bleeding at the surgical site for each participant will be assessed by review of the participant's study records and clinical records and by questioning the caregiver in follow-up. If postoperative bleeding has occurred, details of the episode of bleeding will also be obtained (requirement for surgical intervention, observation at home, or observation at the hospital). (NCT02296840)
Timeframe: 2 weeks after surgery

InterventionParticipants (Count of Participants)
Ibuprofen2
Hydrocodone-acetaminophen0

Reviews

102 reviews available for acetaminophen and Fever

ArticleYear
Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis.
    Journal of healthcare engineering, 2022, Volume: 2022

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen; Odds Ratio; Retrospective Studies

2022
Antipyretic Effectiveness of Oral Acetaminophen Versus Rectal Acetaminophen in Pediatric Patients With Fever.
    Hospital pediatrics, 2022, 06-01, Volume: 12, Issue:6

    Topics: Acetaminophen; Administration, Rectal; Antipyretics; Case-Control Studies; Child; Fever; Humans; Ran

2022
Clinical management of fever in children in Brazil: practical recommendations from an expert panel.
    Einstein (Sao Paulo, Brazil), 2022, Volume: 20

    Topics: Acetaminophen; Antipyretics; Brazil; Child; Fever; Humans; Ibuprofen

2022
Common Selfcare Indications of Pain Medications in Children.
    Paediatric drugs, 2023, Volume: 25, Issue:3

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; COVID-19; Fever; Humans; Ibuprofen; Pain

2023
Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta-analysis of randomized controlled trials.
    Pharmacology research & perspectives, 2023, Volume: 11, Issue:4

    Topics: Acetaminophen; Adult; Antipyretics; Fever; Humans; Ibuprofen; Pain, Postoperative; Randomized Contro

2023
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
    The Cochrane database of systematic reviews, 2023, 08-18, Volume: 8

    Topics: Acetaminophen; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans;

2023
Safety and immunogenicity of co-administered meningococcal serogroup B (4CMenB) vaccine: A literature review.
    Human vaccines & immunotherapeutics, 2023, 08-01, Volume: 19, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Meningococcal Infections; Meningococcal Vaccines; Neisseria men

2023
Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis.
    JAMA network open, 2020, 10-01, Volume: 3, Issue:10

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Female; Fever; Humans; Ibu

2020
Ibuprofen Better than Acetaminophen for Reducing Fever, Pain in Young Children.
    The American journal of nursing, 2021, 02-01, Volume: 121, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Fever; Humans; Ibuprofen; Incidence; Pediatr

2021
Ibuprofen vs. Acetaminophen for Fever or Pain in Children Younger Than Two Years.
    American family physician, 2021, 05-01, Volume: 103, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Ibuprofen; Infant; Pain; Patient Selection;

2021
Acetaminophen and ibuprofen in the treatment of pediatric fever: a narrative review.
    Current medical research and opinion, 2021, Volume: 37, Issue:8

    Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Antipyretics; Child; Fever; Hu

2021
A narrative review of paracetamol-induced hypotension: Keeping the patient safe.
    Nursing open, 2022, Volume: 9, Issue:3

    Topics: Acetaminophen; Critical Illness; Fever; Humans; Hypotension; Hypotension, Controlled

2022
Paracetamol: unconventional uses of a well-known drug.
    The International journal of pharmacy practice, 2021, Dec-04, Volume: 29, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Illicit Drugs; Pain

2021
[Revision of the Dutch College of General Practitioners practice guideline 'Children with fever'].
    Nederlands tijdschrift voor geneeskunde, 2017, Volume: 161

    Topics: Acetaminophen; Child; Family Practice; Fever; General Practitioners; Humans; Ibuprofen; Netherlands;

2017
[Antipyretics in intensive care patients].
    Der Anaesthesist, 2017, Volume: 66, Issue:7

    Topics: Acetaminophen; Antipyretics; Critical Care; Critical Illness; Fever; Humans; Sepsis

2017
Effectiveness of paracetamol versus ibuprofen administration in febrile children: A systematic literature review.
    Journal of paediatrics and child health, 2017, Volume: 53, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Child; Child, Preschool; Fever; Humans; Ibupr

2017
Faster recovery and reduced paracetamol use - a meta-analysis of EPs 7630 in children with acute respiratory tract infections.
    BMC pediatrics, 2019, 04-23, Volume: 19, Issue:1

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Child; Fever; Humans; Recovery of Function;

2019
Does combination treatment with ibuprofen and acetaminophen improve fever control?
    Annals of emergency medicine, 2013, Volume: 61, Issue:5

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Child; Child, Preschool; Drug

2013
A review of dengue fever: a resurging tropical disease.
    Pediatric emergency care, 2013, Volume: 29, Issue:5

    Topics: Acetaminophen; Aedes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Viral; Asia; Car

2013
Question 2: does a failure to respond to antipyretics predict serious illness in children with a fever?
    Archives of disease in childhood, 2013, Volume: 98, Issue:8

    Topics: Acetaminophen; Antipyretics; Child; Fever; Humans; Infant; Male; Treatment Failure

2013
Dosing and antipyretic efficacy of oral acetaminophen in children.
    Clinical therapeutics, 2013, Volume: 35, Issue:9

    Topics: Acetaminophen; Administration, Oral; Antipyretics; Child; Child, Preschool; Drug Dosage Calculations

2013
Combined and alternating paracetamol and ibuprofen therapy for febrile children.
    The Cochrane database of systematic reviews, 2013, Oct-30, Issue:10

    Topics: Acetaminophen; Antipyretics; Body Temperature; Child; Combined Modality Therapy; Fever; Humans; Ibup

2013
Paracetamol: a focus for the general pediatrician.
    European journal of pediatrics, 2014, Volume: 173, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Overdose; Fever; Humans; Pain; Risk Factors

2014
[Risks and benefits of paracetamol in children with fever].
    Nederlands tijdschrift voor geneeskunde, 2014, Volume: 158, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Pain; Risk Assessme

2014
Effects of Leukoreduction and Premedication With Acetaminophen and Diphenhydramine in Minimizing Febrile Nonhemolytic Transfusion Reactions and Allergic Transfusion Reactions During and After Blood Product Administration: A Literature Review With Recommen
    Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses, 2014, Volume: 31, Issue:4

    Topics: Acetaminophen; Diphenhydramine; Drug Administration Schedule; Erythrocyte Transfusion; Evidence-Base

2014
A practical approach to the treatment of low-risk childhood fever.
    Drugs in R&D, 2014, Volume: 14, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen

2014
A practical approach to the treatment of low-risk childhood fever.
    Drugs in R&D, 2014, Volume: 14, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen

2014
A practical approach to the treatment of low-risk childhood fever.
    Drugs in R&D, 2014, Volume: 14, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen

2014
A practical approach to the treatment of low-risk childhood fever.
    Drugs in R&D, 2014, Volume: 14, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen

2014
A practical approach to the treatment of low-risk childhood fever.
    Drugs in R&D, 2014, Volume: 14, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen

2014
A practical approach to the treatment of low-risk childhood fever.
    Drugs in R&D, 2014, Volume: 14, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen

2014
A practical approach to the treatment of low-risk childhood fever.
    Drugs in R&D, 2014, Volume: 14, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen

2014
A practical approach to the treatment of low-risk childhood fever.
    Drugs in R&D, 2014, Volume: 14, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen

2014
A practical approach to the treatment of low-risk childhood fever.
    Drugs in R&D, 2014, Volume: 14, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen

2014
Does paracetamol help or hinder healing in bacterial infections?
    British journal of community nursing, 2014, Volume: 19, Issue:7

    Topics: Acetaminophen; Aged, 80 and over; Anti-Bacterial Agents; Antipyretics; Bacterial Infections; Evidenc

2014
Combined and alternating paracetamol and ibuprofen therapy for febrile children.
    Evidence-based child health : a Cochrane review journal, 2014, Volume: 9, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Child; Child, Preschool; Drug

2014
Intravenous acetaminophen use in pediatrics.
    Pediatric emergency care, 2015, Volume: 31, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Bicycling; Body Weight; Chemic

2015
Question 1: Does prophylactic paracetamol prevent fever after vaccination in infants?
    Archives of disease in childhood, 2015, Volume: 100, Issue:12

    Topics: Acetaminophen; Antipyretics; Evidence-Based Medicine; Fever; Humans; Infant; Male; Vaccination

2015
Vaccines for the prevention of meningococcal capsular group B disease: What have we recently learned?
    Human vaccines & immunotherapeutics, 2016, Volume: 12, Issue:1

    Topics: Acetaminophen; Adolescent; Antipyretics; Chemoprevention; Child; Child, Preschool; Fever; Humans; Im

2016
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
    The Cochrane database of systematic reviews, 2016, 12-15, Volume: 12

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Age

2016
Paracetamol in fever in critically ill patients-an update.
    Journal of critical care, 2017, Volume: 38

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Critical Illness; Cyclooxygenase

2017
A clinical and safety review of paracetamol and ibuprofen in children.
    Inflammopharmacology, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Overdo

2017
Acute Nonspecific Mesenteric Lymphadenitis: More Than "No Need for Surgery".
    BioMed research international, 2017, Volume: 2017

    Topics: Abdomen; Acetaminophen; Acute Disease; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Appendic

2017
Effectiveness of oral vs rectal acetaminophen: a meta-analysis.
    Archives of pediatrics & adolescent medicine, 2008, Volume: 162, Issue:11

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesics, Non-Narcotic; Child; Fever;

2008
[Research advance on pediatric antipyretic].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2008, Volume: 10, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Fever; Humans; Ibuprofen; Sulfonamides

2008
Intravenous paracetamol (acetaminophen).
    Drugs, 2009, Volume: 69, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Child; Controlled Clinical Trials as Topic; Fever; H

2009
Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever.
    Current medical research and opinion, 2009, Volume: 25, Issue:9

    Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Anaphylaxis; Child; Fever; Gastrointestinal Hem

2009
Is combining or alternating antipyretic therapy more beneficial than monotherapy for febrile children?
    BMJ (Clinical research ed.), 2009, Oct-01, Volume: 339

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Combined Modality Therapy; Fever; Humans; Ibuprofen

2009
Clinical safety and tolerability of ibuprofen compared with paracetamol in pediatric pain and fever. A systematic review.
    Minerva pediatrica, 2009, Volume: 61, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Fever; Humans; Ibuprofen; Pain

2009
Did acetaminophen provoke the autism epidemic?
    Alternative medicine review : a journal of clinical therapeutic, 2009, Volume: 14, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Autistic Disorder; Centers for Disease Control and

2009
Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review.
    The Annals of pharmacotherapy, 2010, Volume: 44, Issue:3

    Topics: Acetaminophen; Adult; Age Factors; Analgesics, Non-Narcotic; Child; Female; Fever; Humans; Ibuprofen

2010
Fever management: evaluating the use of ibuprofen and paracetamol.
    Paediatric nursing, 2010, Volume: 22, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Administration Schedule; Emergency Nursing; Fem

2010
Clinical inquiries. Does lowering a fever >101 degrees F in children improve clinical outcomes?
    The Journal of family practice, 2010, Volume: 59, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chickenpox; Cryotherapy; Fasciitis, Necrotizing; Fever; Hum

2010
Pharmacological interventions for the prevention of allergic and febrile non-haemolytic transfusion reactions.
    The Cochrane database of systematic reviews, 2010, Jun-16, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Fever; Histamine H1 Antagon

2010
Intravenous acetaminophen.
    Anesthesiology clinics, 2010, Volume: 28, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Child; Clinical Trials as Topic; Fever; Humans; Inje

2010
Fever without a localizing source.
    Pediatric annals, 2011, Volume: 40, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Bacteremia; Child, Preschool; Female; Fever;

2011
[Efficacy and safety of ibuprofen and paracetamol in fever among children].
    Journal de pharmacie de Belgique, 2011, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Combin

2011
Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone.
    Archives of disease in childhood, 2011, Volume: 96, Issue:12

    Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Child; Child, Pres

2011
Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials.
    Drugs in R&D, 2011, Sep-01, Volume: 11, Issue:3

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Common Cold; Double-Blind Me

2011
Treatment of fever after stroke: conflicting evidence.
    Pharmacotherapy, 2011, Volume: 31, Issue:11

    Topics: Acetaminophen; Animals; Antipyretics; Body Temperature; Fever; Humans; Severity of Illness Index; St

2011
[Fever in non-neurological critically ill patients; friends or foe?].
    Masui. The Japanese journal of anesthesiology, 2011, Volume: 60 Suppl

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Clinical Trials as T

2011
Acetaminophen and Ibuprofen overdosage.
    Pediatrics in review, 2012, Volume: 33, Issue:4

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Chemical and Drug Induced Live

2012
Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold.
    Best practice & research. Clinical gastroenterology, 2012, Volume: 26, Issue:2

    Topics: Acetaminophen; Aspirin; Common Cold; Dyspepsia; Fever; Gastrointestinal Tract; Humans; Ibuprofen; No

2012
Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials.
    Jornal de pediatria, 2012, Volume: 88, Issue:4

    Topics: Acetaminophen; Antipyretics; Child; Drug Substitution; Drug Therapy, Combination; Fever; Humans; Ibu

2012
Optimising the management of fever and pain in children.
    International journal of clinical practice. Supplement, 2013, Issue:178

    Topics: Acetaminophen; Analgesics; Child; Comparative Effectiveness Research; Dose-Response Relationship, Dr

2013
Nursing management of fever in children: a systematic review.
    International journal of nursing practice, 2003, Volume: 9, Issue:1

    Topics: Acetaminophen; Adolescent; Baths; Child; Child, Preschool; Evidence-Based Medicine; Fever; Humans; I

2003
The safety of ibuprofen suspension in children.
    International journal of clinical practice. Supplement, 2003, Issue:135

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Fev

2003
Physical methods for treating fever in children.
    The Cochrane database of systematic reviews, 2003, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Baths; Child; Child, Preschool; Cryotherapy; Fe

2003
Nitric oxide releasing acetaminophen (nitroacetaminophen).
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2003, Volume: 35 Suppl 2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease M

2003
Evidence on the use of paracetamol in febrile children.
    Bulletin of the World Health Organization, 2003, Volume: 81, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Clinical Trials as Topic; Drug Costs; Fever; Global

2003
Antipyretic efficacy and safety of ibuprofen and acetaminophen in children.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:1

    Topics: Acetaminophen; Child; Child, Preschool; Drug Administration Schedule; Fever; Humans; Ibuprofen; Infa

2004
Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis.
    Archives of pediatrics & adolescent medicine, 2004, Volume: 158, Issue:6

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Ibuprof

2004
Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu.
    Journal of clinical pharmacy and therapeutics, 2006, Volume: 31, Issue:4

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Com

2006
Acetaminophen and diphenhydramine premedication for allergic and febrile nonhemolytic transfusion reactions: good prophylaxis or bad practice?
    Transfusion medicine reviews, 2007, Volume: 21, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Allergic Agents; Blood Component Transfusion; Diphenhy

2007
Using paracetamol before immunisation--does it work?
    Nursing New Zealand (Wellington, N.Z. : 1995), 2007, Volume: 13, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Evidence-Based Medicine; Fever; Humans; Pain; Practice Guid

2007
Characterization and clinical management of clozapine-induced fever.
    The Annals of pharmacotherapy, 2007, Volume: 41, Issue:10

    Topics: Acetaminophen; Animals; Clozapine; Disease Management; Fever; Humans

2007
[Answers to the questions on application of ibuprofen and acetaminophen in children with fever].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2007, Volume: 45, Issue:9

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen; Neonatology

2007
A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms.
    Clinical therapeutics, 2007, Volume: 29, Issue:12

    Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Asthma; Child; Fever; Hospitalization; Humans;

2007
[Using evidence-based nursing to explore the management of child fever].
    Hu li za zhi The journal of nursing, 2008, Volume: 55, Issue:2

    Topics: Acetaminophen; Child; Evidence-Based Medicine; Fever; Humans; Ibuprofen

2008
Treatment of fever in 1982: a review.
    The American journal of medicine, 1983, Jun-14, Volume: 74, Issue:6A

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature Regulation; Chemical and Dr

1983
Use of antipyretic analgesics in the pediatric patient.
    The American journal of medicine, 1983, Nov-14, Volume: 75, Issue:5A

    Topics: Acetaminophen; Adolescent; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemic

1983
Review of comparative antipyretic activity in children.
    The American journal of medicine, 1983, Nov-14, Volume: 75, Issue:5A

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Temperature Regulation; Child;

1983
[Body temperature and fever--body temperature regulation, indications and possibilities of fever reducing therapy. II. Indications and effects of fever-lowering procedures and fever-reducing drug therapy].
    Kinderarztliche Praxis, 1981, Volume: 49, Issue:3

    Topics: Acetaminophen; Age Factors; Aminopyrine; Body Temperature Regulation; Child; Child, Preschool; Diclo

1981
[Paracetamol: overdose and hepatic lesions].
    La Clinica terapeutica, 1981, Jul-31, Volume: 98, Issue:2

    Topics: Acetaminophen; Aspirin; Chemical and Drug Induced Liver Injury; Fever; Humans; Liver; Necrosis; Pain

1981
[Amidazophen. Yes or no?].
    Orvosi hetilap, 1995, Sep-24, Volume: 136, Issue:39

    Topics: Acetaminophen; Adult; Aminopyrine; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal

1995
[Paracetamol and other antipyretic analgesics: optimal doses in pediatrics].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1994, Volume: 1, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Dose-Response Relationship, Drug; Dru

1994
Treatment of fever in childhood.
    European journal of pediatrics, 1994, Volume: 153, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Dipyrone; Fever; Humans

1994
[Fever in children: what to do?].
    Archives francaises de pediatrie, 1993, Volume: 50, Issue:3

    Topics: Acetaminophen; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Fever; Humans

1993
Antipyretic therapy.
    Indian pediatrics, 1997, Volume: 34, Issue:5

    Topics: Acetaminophen; Age of Onset; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chil

1997
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Paracetamol or ibuprofen in febrile children.
    Journal of accident & emergency medicine, 1999, Volume: 16, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Emergency Medicine; Evidence-Based Medici

1999
As compared to Paracetamol, does the Paracetamol and Methionine combinations have better efficacy and safety and can it be used safely in the management of pyrexia associated with liver diseases?
    Indian pediatrics, 1999, Volume: 36, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Therapy, Combination; Female; Fever; Humans; Liver Dis

1999
[The controversy surrounding paracetamol therapy in childhood].
    Harefuah, 2000, Jun-01, Volume: 138, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Bacteremia; Child; Fever; Humans

2000
Nonsteroidal anti-inflammatory drugs, acetaminophen, cyclooxygenase 2, and fever.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2000, Volume: 31 Suppl 5

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2;

2000
Toxicities of drugs used in the management of fever.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2000, Volume: 31 Suppl 5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2;

2000
Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review.
    American journal of therapeutics, 2000, Volume: 7, Issue:2

    Topics: Acetaminophen; Alcoholism; Analgesics, Non-Narcotic; Clinical Trials as Topic; Fever; Humans; Liver;

2000
Paracetamol efficacy and safety in children: the first 40 years.
    American journal of therapeutics, 2000, Volume: 7, Issue:2

    Topics: Acetaminophen; Child; Fever; Humans; Nonprescription Drugs; Pain

2000
Paracetamol: past, present, and future.
    American journal of therapeutics, 2000, Volume: 7, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Pain

2000
Childhood fever revisited.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2002, Volume: 8, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Child; Fever; Humans; Ibuprofen; Thermome

2002
Antipyretics in children.
    Indian journal of pediatrics, 2002, Volume: 69, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Child; Cyclooxygenase Inhibitors; Fever; Humans; I

2002
Antipyretics in the paediatric A&E setting: a review.
    Paediatric nursing, 2002, Volume: 14, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Emergency Nursing; Evidence-Based Medicine; Fever; H

2002
Management of the child with fever.
    Collegian (Royal College of Nursing, Australia), 2002, Volume: 9, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Baths; Child; Child, Preschool; Fever; Humans;

2002
Treating fever in children: paracetamol or ibuprofen?
    British journal of community nursing, 2002, Volume: 7, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Effect Modifier, Epidemiologic; Evidence-Based Medic

2002
Paracetamol for treating fever in children.
    The Cochrane database of systematic reviews, 2002, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Infant;

2002
Acetaminophen.
    Annals of internal medicine, 1977, Volume: 87, Issue:2

    Topics: Acetaminophen; Analgesia; Animals; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic;

1977
Aspirin and acetaminophen: a comparative view of their antipyretic and analgesic activity.
    Pediatrics, 1978, Volume: 62, Issue:5 Pt 2 Sup

    Topics: Acetaminophen; Aspirin; Body Temperature; Fever; Humans; Hypothalamus; Pain

1978
Antipyretic therapy in the febrile child.
    Clinical pharmacy, 1992, Volume: 11, Issue:12

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child, Preschool; Drug Therapy, Com

1992
[Treatment of fever in children. False problems or real debate?].
    Presse medicale (Paris, France : 1983), 1991, May-04, Volume: 20, Issue:17

    Topics: Acetaminophen; Aspirin; Child; Fever; Humans

1991
Prophylactic paracetamol with childhood immunisation?
    Drug and therapeutics bulletin, 1990, Sep-17, Volume: 28, Issue:19

    Topics: Acetaminophen; Child; Diphtheria-Tetanus-Pertussis Vaccine; Drug Combinations; Fever; Humans; Measle

1990
How safe is acetaminophen? Some practical cautions with this widely used agent.
    Clinical pediatrics, 1973, Volume: 12, Issue:12

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Chemical Phenomena; Chemistry; Child; Drug Synergism; F

1973
Treatment of salicylate poisoning.
    Modern treatment, 1971, Volume: 8, Issue:3

    Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Acute Kidney Injury; Alkalosis, Respiratory; Aspirin

1971

Trials

177 trials available for acetaminophen and Fever

ArticleYear
[Hyperthermia in children, efficacy of a drinkable solution of paracetamol].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1984, Jan-12, Volume: 60, Issue:1

    Topics: Acetaminophen; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Bacteri

1984
Panic or peace - prioritising infant welfare when medicating feverish infants: a grounded theory study of adherence in a paediatric clinical trial.
    BMC pediatrics, 2022, 04-11, Volume: 22, Issue:1

    Topics: Acetaminophen; Asthma; Fever; Grounded Theory; Humans; Ibuprofen; Infant; Infant Welfare

2022
Aggressive antipyretics in central nervous system malaria: Study protocol of a randomized-controlled trial assessing antipyretic efficacy and parasite clearance effects (Malaria FEVER study).
    PloS one, 2022, Volume: 17, Issue:10

    Topics: Acetaminophen; Animals; Antipyretics; Central Nervous System; Child; Fever; Histidine; Humans; Ibupr

2022
Comparing the effect of body wash with marshmallow plant and lukewarm water on reducing the temperature of febrile children: a randomized clinical trial.
    BMC complementary medicine and therapies, 2022, Nov-12, Volume: 22, Issue:1

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen; Iran; Temperature; Water

2022
A Randomized Study on the Prophylactic Use of Acetaminophen to Prevent Fever after the Removal of Drainage Tubes for Lumbar Surgery.
    Orthopaedic surgery, 2023, Volume: 15, Issue:2

    Topics: Acetaminophen; Antipyretics; Device Removal; Drainage; Fever; Humans; Length of Stay; Lumbar Vertebr

2023
A Randomized Study on the Prophylactic Use of Acetaminophen to Prevent Fever after the Removal of Drainage Tubes for Lumbar Surgery.
    Orthopaedic surgery, 2023, Volume: 15, Issue:2

    Topics: Acetaminophen; Antipyretics; Device Removal; Drainage; Fever; Humans; Length of Stay; Lumbar Vertebr

2023
A Randomized Study on the Prophylactic Use of Acetaminophen to Prevent Fever after the Removal of Drainage Tubes for Lumbar Surgery.
    Orthopaedic surgery, 2023, Volume: 15, Issue:2

    Topics: Acetaminophen; Antipyretics; Device Removal; Drainage; Fever; Humans; Length of Stay; Lumbar Vertebr

2023
A Randomized Study on the Prophylactic Use of Acetaminophen to Prevent Fever after the Removal of Drainage Tubes for Lumbar Surgery.
    Orthopaedic surgery, 2023, Volume: 15, Issue:2

    Topics: Acetaminophen; Antipyretics; Device Removal; Drainage; Fever; Humans; Length of Stay; Lumbar Vertebr

2023
Randomised evaluation of active control of temperature versus ordinary temperature management (REACTOR) trial.
    Intensive care medicine, 2019, Volume: 45, Issue:10

    Topics: Acetaminophen; Adult; Aged; Antipyretics; Australia; Body Temperature; Brain Diseases; Chi-Square Di

2019
Ibuprofen versus paracetamol for treating fever in preschool children in Nigeria: a randomized clinical trial of effectiveness and safety.
    The Pan African medical journal, 2020, Volume: 36

    Topics: Acetaminophen; Antipyretics; Body Temperature; Child, Preschool; Female; Fever; Hospitals, Teaching;

2020
Randomized control trial of intravenous acetaminophen for reduction of intrapartum maternal fever.
    American journal of obstetrics & gynecology MFM, 2021, Volume: 3, Issue:1

    Topics: Acetaminophen; Female; Fever; Humans; Infant, Newborn; Interleukin-13; Interleukin-2; Placenta; Preg

2021
Randomised comparative trial of the efficacy of paracetamol syrup and dispersible tablets for the treatment of fever in children.
    The Journal of international medical research, 2021, Volume: 49, Issue:3

    Topics: Acetaminophen; Antipyretics; Child; Double-Blind Method; Fever; Humans; Tablets

2021
Comparison of intravenous ibuprofen and paracetamol in the treatment of fever: A randomized double-blind study.
    The American journal of emergency medicine, 2021, Volume: 46

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Double-Blind Method; Em

2021
Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial.
    Critical care medicine, 2017, Volume: 45, Issue:7

    Topics: Acetaminophen; Adult; Aged; Blood Pressure; Body Temperature; Critical Illness; Double-Blind Method;

2017
Effect of prophylactic or therapeutic administration of paracetamol on immune response to DTwP-HepB-Hib combination vaccine in Indian infants.
    Vaccine, 2017, 05-19, Volume: 35, Issue:22

    Topics: Acetaminophen; Antibodies, Bacterial; Diphtheria; Diphtheria-Tetanus-Pertussis Vaccine; Female; Feve

2017
Alternating Acetaminophen and Ibuprofen versus Monotherapies in Improvements of Distress and Reducing Refractory Fever in Febrile Children: A Randomized Controlled Trial.
    Paediatric drugs, 2017, Volume: 19, Issue:5

    Topics: Acetaminophen; Antipyretics; Child; Child, Preschool; Drug Administration Schedule; Drug Therapy, Co

2017
Comparison of Antipyretic Efficacy of Intravenous (IV) Acetaminophen versus Oral (PO) Acetaminophen in the Management of Fever in Children.
    Indian journal of pediatrics, 2018, Volume: 85, Issue:1

    Topics: Acetaminophen; Administration, Oral; Antipyretics; Child; Female; Fever; Humans; Injections, Intrave

2018
Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury.
    Journal of critical care, 2018, Volume: 47

    Topics: Acetaminophen; Adult; Antipyretics; Area Under Curve; Brain Injuries, Traumatic; Critical Illness; D

2018
The antipyretic efficacy and safety of propacetamol compared with dexibuprofen in febrile children: a multicenter, randomized, double-blind, comparative, phase 3 clinical trial.
    BMC pediatrics, 2018, 06-23, Volume: 18, Issue:1

    Topics: Acetaminophen; Administration, Oral; Adolescent; Antipyretics; Child; Child, Preschool; Double-Blind

2018
[In process].
    Medizinische Monatsschrift fur Pharmazeuten, 2016, Volume: 39, Issue:10

    Topics: Acetaminophen; Asthma; Child, Preschool; Disease Progression; Fever; Humans; Ibuprofen; Pain; Prospe

2016
Effect of standard dose paracetamol versus placebo as antipyretic therapy on liver injury in adult dengue infection: a multicentre randomised controlled trial.
    The Lancet. Global health, 2019, Volume: 7, Issue:5

    Topics: Acetaminophen; Adult; Alanine Transaminase; Antipyretics; Aspartate Aminotransferases; Dengue; Doubl

2019
Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 °
    International journal of stroke : official journal of the International Stroke Society, 2015, Volume: 10, Issue:3

    Topics: Acetaminophen; Antipyretics; Body Temperature; Clinical Protocols; Dose-Response Relationship, Drug;

2015
Temperature management in patients with acute neurological lesions: an Australian and New Zealand point prevalence study.
    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2013, Volume: 15, Issue:2

    Topics: Acetaminophen; Antipyretics; Australia; Body Temperature; Brain Injuries; Dose-Response Relationship

2013
Statistical analysis plan for the HEAT trial: a multicentre randomised placebo-controlled trial of intravenous paracetamol in intensive care unit patients with fever and infection.
    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2013, Volume: 15, Issue:4

    Topics: Acetaminophen; Administration, Intravenous; Antipyretics; Clinical Trials, Phase II as Topic; Critic

2013
Intravenous paracetamol as an antipyretic and analgesic medication: the significance of drug metabolism.
    Journal of pharmacological sciences, 2014, Volume: 124, Issue:2

    Topics: Abdominal Pain; Acetaminophen; Adolescent; Adult; Aged; Female; Fever; Humans; Infections; Infusions

2014
Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Female; Fever; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Va

2014
Features and management of pyrexia with combined dabrafenib and trametinib in metastatic melanoma.
    Melanoma research, 2014, Volume: 24, Issue:5

    Topics: Acetaminophen; Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antine

2014
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
    The New England journal of medicine, 2015, Dec-03, Volume: 373, Issue:23

    Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans;

2015
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
    The New England journal of medicine, 2015, Dec-03, Volume: 373, Issue:23

    Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans;

2015
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
    The New England journal of medicine, 2015, Dec-03, Volume: 373, Issue:23

    Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans;

2015
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
    The New England journal of medicine, 2015, Dec-03, Volume: 373, Issue:23

    Topics: Acetaminophen; Aged; Body Temperature; Critical Illness; Double-Blind Method; Female; Fever; Humans;

2015
The Effect of Paracetamol on Core Body Temperature in Acute Traumatic Brain Injury: A Randomised, Controlled Clinical Trial.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Acetaminophen; Adult; Antipyretics; Body Temperature; Brain Injuries; Double-Blind Method; Female; F

2015
Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.
    The New England journal of medicine, 2016, Aug-18, Volume: 375, Issue:7

    Topics: Acetaminophen; Asthma; Child, Preschool; Double-Blind Method; Female; Fever; Humans; Ibuprofen; Inci

2016
Effects of prophylactic ibuprofen and paracetamol administration on the immunogenicity and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugated vaccine (PHiD-CV) co-administered with DTPa-combined vaccines
    Human vaccines & immunotherapeutics, 2017, 03-04, Volume: 13, Issue:3

    Topics: Acetaminophen; Antibodies, Bacterial; Antipyretics; Diphtheria-Tetanus-acellular Pertussis Vaccines;

2017
Randomized, controlled, multicentre clinical trial of the antipyretic effect of intravenous paracetamol in patients admitted to hospital with infection.
    British journal of clinical pharmacology, 2017, Volume: 83, Issue:4

    Topics: Acetaminophen; Administration, Intravenous; Adult; Aged; Antipyretics; Double-Blind Method; Female;

2017
Antipyretic Efficacy and Safety of Ibuprofen Versus Acetaminophen Suspension in Febrile Children: Results of 2 Randomized, Double-Blind, Single-Dose Studies.
    Clinical pediatrics, 2017, Volume: 56, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Chil

2017
A multicenter, randomized, open-label, active-comparator trial to determine the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for treatment of fever in hospitalized pediatric patients.
    BMC pediatrics, 2017, 02-01, Volume: 17, Issue:1

    Topics: Acetaminophen; Administration, Oral; Adolescent; Antipyretics; Area Under Curve; Child; Child, Presc

2017
A randomized study of fever prophylaxis and the immunogenicity of routine pediatric vaccinations.
    Vaccine, 2017, 04-04, Volume: 35, Issue:15

    Topics: Acetaminophen; Antibodies, Bacterial; Antipyretics; Chemoprevention; Diphtheria-Tetanus-Pertussis Va

2017
PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial.
    Stroke, 2017, Volume: 48, Issue:4

    Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Brain Ischemia; Cerebral Hemorrhage; Double-Bl

2017
Alternating antipyretics: antipyretic efficacy of acetaminophen versus acetaminophen alternated with ibuprofen in children.
    Clinical pediatrics, 2008, Volume: 47, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Double-Blind Method; Female; Fever

2008
Prophylactic use of acetaminophen in children vaccinated with diphtheria-tetanus-pertussis.
    World journal of pediatrics : WJP, 2008, Volume: 4, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anorexia; Chemoprevention; Diphtheria-Tetanus-Pertussis Vac

2008
A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions.
    Transfusion, 2008, Volume: 48, Issue:11

    Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Do

2008
Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial.
    BMJ (Clinical research ed.), 2008, Sep-02, Volume: 337

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Child; Child, Preschool; Drug Therapy, Co

2008
Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): economic evaluation of a randomised controlled trial.
    BMJ (Clinical research ed.), 2008, Sep-09, Volume: 337

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Cost-Benefit Analysis; Drug Therap

2008
Correction: PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN74418480].
    BMC cardiovascular disorders, 2008, Nov-04, Volume: 8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Clinical Protocols; Double-Blind Method; Fever; Humans; Log

2008
Antipyretic effect of ketoprofen.
    Indian journal of pediatrics, 2009, Volume: 76, Issue:3

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents,

2009
Paracetamol and ibuprofen for the treatment of fever in children: the PITCH randomised controlled trial.
    Health technology assessment (Winchester, England), 2009, Volume: 13, Issue:27

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Cost-Benefit Analysis; Double-Blin

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antibody Formation; Chemoprevention; Female; Fever; Humans;

2009
Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique.
    International journal of oral and maxillofacial surgery, 2010, Volume: 39, Issue:2

    Topics: Acetaminophen; Adult; Amoxicillin; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Bacterial Agen

2010
Dose-finding studies of ketoprofen in the management of fever in children: report on two randomized, single-blind, comparator-controlled, single-dose, multicentre, phase II studies.
    Clinical drug investigation, 2010, Volume: 30, Issue:4

    Topics: Acetaminophen; Administration, Oral; Age Factors; Analgesics, Non-Narcotic; Anti-Inflammatory Agents

2010
Ketoprofen versus paracetamol (acetaminophen) or ibuprofen in the management of fever: results of two randomized, double-blind, double-dummy, parallel-group, repeated-dose, multicentre, phase III studies in children.
    Clinical drug investigation, 2010, Volume: 30, Issue:6

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid

2010
Effect of acetaminophen and fluvastatin on post-dose symptoms following infusion of zoledronic acid.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2011, Volume: 22, Issue:8

    Topics: Acetaminophen; Acute-Phase Reaction; Aged; Antipyretics; Bone Density Conservation Agents; Diphospho

2011
Safety of multiple-dose intravenous acetaminophen in adult inpatients.
    Pain medicine (Malden, Mass.), 2010, Volume: 11, Issue:12

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Fever; Humans; Injections, Intravenous; Pain; Prospe

2010
Treatment with acetaminophen/paracetamol or ibuprofen alleviates post-dose symptoms related to intravenous infusion with zoledronic acid 5 mg.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012, Volume: 23, Issue:2

    Topics: Acetaminophen; Aged; Arthralgia; Body Temperature; Bone Density Conservation Agents; Diphosphonates;

2012
Efficacy of standard doses of Ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children.
    Clinical therapeutics, 2010, Volume: 32, Issue:14

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Child; Child, Preschool; Dose-

2010
Efficacy of standard doses of Ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children.
    Clinical therapeutics, 2010, Volume: 32, Issue:14

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Child; Child, Preschool; Dose-

2010
Efficacy of standard doses of Ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children.
    Clinical therapeutics, 2010, Volume: 32, Issue:14

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Child; Child, Preschool; Dose-

2010
Efficacy of standard doses of Ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children.
    Clinical therapeutics, 2010, Volume: 32, Issue:14

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Child; Child, Preschool; Dose-

2010
A randomized study of the efficacy and safety of intravenous acetaminophen compared to oral acetaminophen for the treatment of fever.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2011, Volume: 18, Issue:4

    Topics: Acetaminophen; Administration, Oral; Adult; Antipyretics; Double-Blind Method; Endotoxins; Fever; Hu

2011
A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients.
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Academic Medical Centers; Acetaminophen; Antipyretics; Body Temperature; Drug Therapy, Combination;

2011
A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients.
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Academic Medical Centers; Acetaminophen; Antipyretics; Body Temperature; Drug Therapy, Combination;

2011
A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients.
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Academic Medical Centers; Acetaminophen; Antipyretics; Body Temperature; Drug Therapy, Combination;

2011
A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients.
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Academic Medical Centers; Acetaminophen; Antipyretics; Body Temperature; Drug Therapy, Combination;

2011
A randomized study of the efficacy and safety of intravenous acetaminophen vs. intravenous placebo for the treatment of fever.
    Clinical pharmacology and therapeutics, 2011, Volume: 90, Issue:1

    Topics: Acetaminophen; Adult; Alanine Transaminase; Antipyretics; Aspartate Aminotransferases; Body Temperat

2011
Fever and fever management among intensive care patients with known or suspected infection: a multicentre prospective cohort study.
    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2011, Volume: 13, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Anti-Bacterial Agents; Antipyretics; Australia; Bacterial Infectio

2011
Paracetamol versus placebo in treatment of non-severe malaria in children in Guinea-Bissau: a randomized controlled trial.
    Malaria journal, 2011, Jun-01, Volume: 10

    Topics: Acetaminophen; Adolescent; Antipyretics; Body Temperature; Child; Child, Preschool; Female; Fever; G

2011
Comparison of the antipyretic efficacy of ketoprofen, acetylsalicylic acid, and paracetamol, orally administered to swine.
    Journal of veterinary pharmacology and therapeutics, 2012, Volume: 35, Issue:2

    Topics: Acetaminophen; Administration, Oral; Animals; Antipyretics; Aspirin; Fever; Ketoprofen; Lipopolysacc

2012
A randomized placebo-controlled trial of acetaminophen for prevention of post-vaccination fever in infants.
    PloS one, 2011, Volume: 6, Issue:6

    Topics: Acetaminophen; Fever; Humans; Infant; Pertussis Vaccine; Placebos; Sample Size

2011
Comparison of acetaminophen and ketoprofen in febrile children: a single dose randomized clinical trial.
    Indian journal of pediatrics, 2012, Volume: 79, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Child; Child, Preschool; Femal

2012
Immediate versus as-needed acetaminophen for post-immunisation pyrexia.
    Annals of tropical paediatrics, 2011, Volume: 31, Issue:4

    Topics: Acetaminophen; Antipyretics; Chemoprevention; Diphtheria-Tetanus-Pertussis Vaccine; Female; Fever; H

2011
Acetaminophen pediatric dose selection: caregiver satisfaction regarding the antipyretic efficacy of acetaminophen in children.
    Clinical pediatrics, 2012, Volume: 51, Issue:11

    Topics: Acetaminophen; Administration, Oral; Adult; Algorithms; Antipyretics; Caregivers; Child, Preschool;

2012
Assessment of the safety and feasibility of administering antipyretic therapy in critically ill adults: a pilot randomized clinical trial.
    Journal of critical care, 2013, Volume: 28, Issue:3

    Topics: Acetaminophen; Aged; Antipyretics; Chi-Square Distribution; Critical Illness; Feasibility Studies; F

2013
A novel paracetamol 1,000 mg sustained release formulation vs conventional paracetamol 500 mg formulation in patients with fever and pain: a randomized noninferiority trial.
    Pain medicine (Malden, Mass.), 2013, Volume: 14, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antipyretics; Delayed-Action Prepa

2013
Comparison of oral versus normal and high-dose rectal acetaminophen in the treatment of febrile children.
    Pediatrics, 2002, Volume: 110, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesics, Non-Narcotic; Child; Child,

2002
Elevated maternal and fetal serum interleukin-6 levels are associated with epidural fever.
    American journal of obstetrics and gynecology, 2002, Volume: 187, Issue:4

    Topics: Acetaminophen; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Double-Blind M

2002
[Metamizol versus propacetamol: comparative study of the hemodynamic and antipyretic effects in critically ill patients].
    Revista espanola de anestesiologia y reanimacion, 2002, Volume: 49, Issue:8

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Critical Illness; Dipyrone; Female; Fever; H

2002
Symptomatic intravenous antipyretic therapy: efficacy of metamizol, diclofenac, and propacetamol.
    Journal of pain and symptom management, 2002, Volume: 24, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammato

2002
Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690].
    BMC cardiovascular disorders, 2003, Feb-06, Volume: 3

    Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida

2003
Intravenous corticosteroids to reduce gemtuzumab ozogamicin infusion reactions.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:9

    Topics: Acetaminophen; Adult; Aminoglycosides; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflamm

2003
[Treatment of stroke by reducing the body temperature; 'Paracetamol (acetaminophen) in stroke' (PAIS): start of a clinical trial].
    Nederlands tijdschrift voor geneeskunde, 2003, Oct-04, Volume: 147, Issue:40

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Body Temperature; Double-Blind Method; Fever

2003
Acetylsalicylic acid and acetaminophen to combat elevated body temperature in acute ischemic stroke.
    Cerebrovascular diseases (Basel, Switzerland), 2004, Volume: 17, Issue:2-3

    Topics: Acetaminophen; Acute Disease; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida

2004
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response.
    Intensive care medicine, 2004, Volume: 30, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Body Temperature; Cryotherapy; Cytoki

2004
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response.
    Intensive care medicine, 2004, Volume: 30, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Body Temperature; Cryotherapy; Cytoki

2004
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response.
    Intensive care medicine, 2004, Volume: 30, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Body Temperature; Cryotherapy; Cytoki

2004
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response.
    Intensive care medicine, 2004, Volume: 30, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Body Temperature; Cryotherapy; Cytoki

2004
The antipyretic effect of ibuprofen and acetaminophen in children.
    Pharmacotherapy, 2004, Volume: 24, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Child; Child, Preschool; Fever; Half-Life

2004
Prophylactic acetaminophen does not prevent epidural fever in nulliparous women: a double-blind placebo-controlled trial.
    Journal of perinatology : official journal of the California Perinatal Association, 2004, Volume: 24, Issue:8

    Topics: Acetaminophen; Adult; Anesthesia, Epidural; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Me

2004
Corticosteroids, ibuprofen, and acetaminophen for IFNbeta-1a flu symptoms in MS: a randomized trial.
    Neurology, 2004, Aug-10, Volume: 63, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthenia; Chills; Double-Blind Method; Drug Administ

2004
[Antipyretic effectiveness of ibuprofen and paracetamol].
    Anales de pediatria (Barcelona, Spain : 2003), 2005, Volume: 62, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Fever; Humans; Ibuprofen;

2005
When fever, paracetamol? Theory and practice in a paediatric outpatient clinic.
    Pharmacy world & science : PWS, 2005, Volume: 27, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Body Weight; Child, Preschool; Data Colle

2005
Equal antipyretic effectiveness of oral and rectal acetaminophen: a randomized controlled trial [ISRCTN11886401].
    BMC pediatrics, 2005, Sep-06, Volume: 5

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Adolescent; Analgesics, Non-Narcotic; B

2005
Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging st
    Clinical therapeutics, 2005, Volume: 27, Issue:7

    Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspi

2005
The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study.
    Surgical infections, 2005,Winter, Volume: 6, Issue:4

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Body Temperature; Body Temperature Regulation;

2005
Antipyretic treatment in young children with fever: acetaminophen, ibuprofen, or both alternating in a randomized, double-blind study.
    Archives of pediatrics & adolescent medicine, 2006, Volume: 160, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Double-Blind Method; Drug Therapy, Combin

2006
Randomised controlled trial of combined paracetamol and ibuprofen for fever.
    Archives of disease in childhood, 2006, Volume: 91, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Drug Therapy, Combination; Emergen

2006
Alternating ibuprofen and acetaminophen in the treatment of febrile children: a pilot study [ISRCTN30487061].
    BMC medicine, 2006, Mar-04, Volume: 4

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid

2006
Antipyretic efficacy and tolerability of a single intravenous dose of the acetaminophen prodrug propacetamol in children: a randomized, double-blind, placebo-controlled trial.
    Clinical therapeutics, 2006, Volume: 28, Issue:5

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Double-

2006
Antipyretic efficacy and safety of a single intravenous administration of 15 mg/kg paracetamol versus 30 mg/kg propacetamol in children with acute fever due to infection.
    International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:4

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Child; Child, Preschool; Double-Blind Method

2007
The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.
    BMC medicine, 2007, May-30, Volume: 5

    Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Alcoholism; Analgesics, Non-Narcotic; Aspart

2007
Ibuprofen versus paracetamol in pediatric fever: objective and subjective findings from a randomized, blinded study.
    Current medical research and opinion, 2007, Volume: 23, Issue:9

    Topics: Acetaminophen; Child; Child, Preschool; Double-Blind Method; Female; Fever; Humans; Ibuprofen; Infan

2007
A prospective, observational clinical trial of fever reduction to reduce systemic oxygen consumption in the setting of acute brain injury.
    Neurocritical care, 2008, Volume: 9, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Body Temperature; Brain Injuries; Combined M

2008
The association between acetaminophen concentrations in the cerebrospinal fluid and temperature decline in febrile infants.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Monitoring; Female; Fever; Humans; Infant; Male; Time

2007
Role of paracetamol in treatment of childhood Fever: a double-blind randomized placebo controlled trial.
    Indian pediatrics, 2007, Volume: 44, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Fever; Humans; Infant; Liv

2007
The effects of remifentanil or acetaminophen with epidural ropivacaine on body temperature during labor.
    Journal of anesthesia, 2008, Volume: 22, Issue:2

    Topics: Acetaminophen; Adult; Amides; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Obstetrical;

2008
[Trial of oral paracetamol solution in febrile children].
    Annales de pediatrie, 1983, Volume: 30, Issue:2

    Topics: Acetaminophen; Child, Preschool; Clinical Trials as Topic; Female; Fever; Humans; Male; Solutions

1983
Acetaminophen accumulation in pediatric patients after repeated therapeutic doses.
    European journal of clinical pharmacology, 1984, Volume: 27, Issue:1

    Topics: Acetaminophen; Child; Child, Preschool; Female; Fever; Humans; Infant; Kidney Function Tests; Kineti

1984
Primary care of hyperpyrexia. Evaluation of a simple physical method.
    Indian pediatrics, 1984, Volume: 21, Issue:12

    Topics: Acetaminophen; Baths; Child; Child, Preschool; Evaluation Studies as Topic; Fever; Humans; Infant

1984
[Analgesic, antipyretic and anti-rheumatic activity of 2 preparations evaluated in a multicenter clinical trial].
    La Clinica terapeutica, 1982, Dec-15, Volume: 103, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Child; Child, Preschool; Clinical Trials

1982
Comparative efficacy of aspirin and acetaminophen in the reduction of fever in children.
    Archives of internal medicine, 1981, Feb-23, Volume: 141, Issue:3 Spec No

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Clinical T

1981
A comparison of nimesulide vs paracetamol in the treatment of pyrexia in the elderly.
    Drugs, 1993, Volume: 46 Suppl 1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method

1993
A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children.
    Drugs, 1993, Volume: 46 Suppl 1

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Fever; Huma

1993
Correcting respiratory rate for the presence of fever.
    Journal of clinical epidemiology, 1994, Volume: 47, Issue:9

    Topics: Acetaminophen; Child, Preschool; Double-Blind Method; Female; Fever; Humans; Infant; Male; Respirati

1994
Pretreatment regimens for adverse events related to infusion of amphotericin B.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 20, Issue:4

    Topics: Acetaminophen; Adrenal Cortex Hormones; Amphotericin B; Diphenhydramine; Fever; Headache; Heparin; H

1995
Risks of antipyretics in young children with fever due to infectious disease.
    Acta paediatrica Japonica : Overseas edition, 1994, Volume: 36, Issue:4

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Bacterial Infections; Child; Child, Preschool;

1994
Evaluation of the antipyretic effect of ketorolac, acetaminophen, and placebo in endotoxin-induced fever.
    Journal of clinical pharmacology, 1994, Volume: 34, Issue:8

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

1994
Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria.
    Annals of tropical medicine and parasitology, 1994, Volume: 88, Issue:4

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Female; Fever; Humans; Indomethacin; Malaria

1994
Tepid sponging to reduce temperature in febrile children in a tropical climate.
    Clinical pediatrics, 1994, Volume: 33, Issue:4

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Body Temperature; Child, Preschool; Co

1994
Efficacy and safety of aerosolized ribavirin in young children hospitalized with influenza: a double-blind, multicenter, placebo-controlled trial.
    The Journal of pediatrics, 1994, Volume: 125, Issue:1

    Topics: Acetaminophen; Administration, Inhalation; Antibodies, Viral; Child, Preschool; Double-Blind Method;

1994
Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics.
    European journal of clinical pharmacology, 1994, Volume: 46, Issue:3

    Topics: Acetaminophen; Anti-Bacterial Agents; Child, Preschool; Double-Blind Method; Female; Fever; Humans;

1994
Antipyretic effectiveness of acetaminophen in febrile seizures: ongoing prophylaxis versus sporadic usage.
    European journal of pediatrics, 1993, Volume: 152, Issue:9

    Topics: Acetaminophen; Body Temperature; Child, Preschool; Drug Administration Schedule; Female; Fever; Huma

1993
Primary immunization series for infants: comparison of two-component acellular and standard whole-cell pertussis vaccines combined with diphtheria-tetanus toxoids.
    Southern medical journal, 1993, Volume: 86, Issue:3

    Topics: Academic Medical Centers; Acetaminophen; Antibody Formation; Diphtheria-Tetanus-Pertussis Vaccine; D

1993
Nimesulide in the treatment of hyperpyrexia in the aged. Double-blind comparison with paracetamol.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:2

    Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Bod

1993
Reduction of the initial febrile response to OKT3 with indomethacin.
    Transplantation proceedings, 1993, Volume: 25, Issue:2 Suppl 1

    Topics: Acetaminophen; Adult; Creatinine; Diphenhydramine; Drug Administration Schedule; Female; Fever; Graf

1993
Comparing efficacy and tolerability of ibuprofen and paracetamol in fever.
    Archives of disease in childhood, 1996, Volume: 74, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Child; Child, Preschool; D

1996
Choice of antipyretic in children.
    The Journal of the Association of Physicians of India, 1995, Volume: 43, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres

1995
Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever.
    European journal of clinical pharmacology, 1997, Volume: 51, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Temp

1997
Metabolic effects of i.v. propacetamol, metamizol or external cooling in critically ill febrile sedated patients.
    British journal of anaesthesia, 1997, Volume: 78, Issue:2

    Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Critical Illness; Cross-Over St

1997
The efficacy of tepid sponge bathing to reduce fever in young children.
    The American journal of emergency medicine, 1997, Volume: 15, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Baths; Body Temperature; Child; Child, Preschool; Combined

1997
Evaluation of sponging and antipyretic medication to reduce body temperature in febrile children.
    Acta paediatrica Japonica : Overseas edition, 1997, Volume: 39, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Baths; Child, Preschool; Female; Fever; Humans; Ib

1997
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1997
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1997
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1997
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1997
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1997
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1997
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1997
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1997
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

1997
Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria.
    Lancet (London, England), 1997, Sep-06, Volume: 350, Issue:9079

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Child; Child, Preschool; Female; Fever; Humans; In

1997
Renal function after short-term ibuprofen use in infants and children.
    Pediatrics, 1997, Volume: 100, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Urea Nitroge

1997
Equivalent antipyretic activity of ibuprofen and paracetamol in febrile children.
    The Journal of pediatrics, 1997, Volume: 131, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres

1997
Efficacy of tepid sponging versus paracetamol in reducing temperature in febrile children.
    Annals of tropical paediatrics, 1997, Volume: 17, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature Regulation; Child, Preschool; Female; Feve

1997
Antipyretic effect of oral v. rectal paracetamol.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1997, Volume: 87, Issue:12

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesics, Non-Narcotic; Child, Presch

1997
[The experience with solpadeine -- a new analgesic].
    Klinicheskaia meditsina, 1997, Volume: 75, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Analgesics, Non-Narcotic; Caffeine; Codeine; Drug Comb

1997
Amelioration of flulike symptoms at the onset of interferon beta-1b therapy in multiple sclerosis by low-dose oral steroids is related to a decrease in interleukin-6 induction.
    Annals of neurology, 1998, Volume: 44, Issue:4

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Dose-Response Relationship, Dr

1998
Double blind randomized comparative evaluation of nimesulide and paracetamol as antipyretics.
    Indian pediatrics, 1998, Volume: 35, Issue:6

    Topics: Abdominal Pain; Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Ax

1998
Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial.
    Clinical pharmacology and therapeutics, 1999, Volume: 66, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Aspirin; Body Temperature; Double-Blind Method; Endo

1999
The safety of acetaminophen and ibuprofen among children younger than two years old.
    Pediatrics, 1999, Volume: 104, Issue:4

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Asthma; Bronchiolitis; Double-Blind Method;

1999
Ketorolac versus acetaminophen for treatment of acute fever in the emergency department.
    Southern medical journal, 1999, Volume: 92, Issue:12

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Body Temperature; Doub

1999
Interferon treatment of chronic hepatitis C in patients cured of pediatric malignancies.
    Haematologica, 2000, Volume: 85, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Alopecia; Asthenia; Chlorpheniramine; DNA, V

2000
Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections.
    European journal of clinical pharmacology, 1999, Volume: 55, Issue:9

    Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Infla

1999
Acetaminophen controlled-release sprinkles versus acetaminophen immediate-release elixir in febrile children.
    Journal of clinical pharmacology, 2000, Volume: 40, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anxiety; Area Under Curve; Body Temperature; Child; Child,

2000
Stroke severity determines body temperature in acute stroke.
    Stroke, 2001, Volume: 32, Issue:2

    Topics: Acetaminophen; Acute Disease; Aged; Aged, 80 and over; Anticoagulants; Body Temperature; Cerebral He

2001
Antipyretic effects of nimesulide, paracetamol and ibuprofen-paracetamol.
    Indian journal of pediatrics, 2000, Volume: 67, Issue:12

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Double-Blind Method; Drug

2000
Early pregnancy termination with vaginal misoprostol combined with loperamide and acetaminophen prophylaxis.
    Contraception, 2001, Volume: 63, Issue:4

    Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Acetaminophen; Administration, Intravaginal;

2001
Comparison of fever treatments in the critically ill: a pilot study.
    American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2001, Volume: 10, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Combined Modality Therapy; Critical Care; Critical Illness;

2001
Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial.
    Stroke, 2001, Volume: 32, Issue:7

    Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Brain Ischemia; Double-Blind Method; Female; F

2001
Antipyretic efficacy of an initial 30-mg/kg loading dose of acetaminophen versus a 15-mg/kg maintenance dose.
    Pediatrics, 2001, Volume: 108, Issue:4

    Topics: Acetaminophen; Administration, Oral; Ambulatory Care; Analgesics, Non-Narcotic; Child; Child, Presch

2001
Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial.
    Stroke, 2002, Volume: 33, Issue:1

    Topics: Acetaminophen; Acute Disease; Aged; Body Temperature; Double-Blind Method; Female; Fever; Humans; Hy

2002
Antipyretic effects of dipyrone versus ibuprofen versus acetaminophen in children: results of a multinational, randomized, modified double-blind study.
    Clinical pediatrics, 2001, Volume: 40, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroid

2001
Asthma morbidity after the short-term use of ibuprofen in children.
    Pediatrics, 2002, Volume: 109, Issue:2

    Topics: Acetaminophen; Age Factors; Ambulatory Care; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non

2002
Both paracetamol and ibuprofen are equally effective in managing flu-like symptoms in relapsing-remitting multiple sclerosis patients during interferon beta-1a (AVONEX) therapy.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2002, Volume: 8, Issue:1

    Topics: Acetaminophen; Adult; Chills; Female; Fever; Headache; Humans; Ibuprofen; Interferon beta-1a; Interf

2002
Comparison of antipyretic effect of nimesulide and paracetamol in children attending a secondary level hospital.
    Indian pediatrics, 2002, Volume: 39, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres

2002
Effectiveness and tolerability of ibuprofen-arginine versus paracetamol in children with fever of likely infectious origin.
    Acta paediatrica (Oslo, Norway : 1992), 2002, Volume: 91, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Arginine; Child; Child, Preschool; Double-Blind Method; Dru

2002
Sulfadoxine-pyrimethamine monotherapy in Tanzanian children gives rapid parasite clearance but slow fever clearance that is improved by chloroquine in combination therapy.
    Tropical medicine & international health : TM & IH, 2002, Volume: 7, Issue:7

    Topics: Acetaminophen; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Dru

2002
[On the antipyretic effect of paracetamol. Clinical investigation with two different forms of application (author's transl)].
    Medizinische Klinik, 1978, Jan-06, Volume: 73, Issue:1

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Dosage Forms; Doxyl

1978
Acetaminophen.
    Annals of internal medicine, 1977, Volume: 87, Issue:2

    Topics: Acetaminophen; Analgesia; Animals; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic;

1977
Antipyretic therapy. Comparison of rectal and oral paracetamol.
    European journal of clinical pharmacology, 1977, Aug-17, Volume: 12, Issue:1

    Topics: Acetaminophen; Administration, Oral; Adult; Child; Child, Preschool; Clinical Trials as Topic; Fever

1977
Rectal paracetamol in small children with fever.
    Archives of disease in childhood, 1979, Volume: 54, Issue:6

    Topics: Acetaminophen; Administration, Oral; Child; Child, Preschool; Fever; Humans; Infant; Random Allocati

1979
The antipyretic effectiveness of acetaminophen suppositories versus tablets: a double-blind study.
    Current therapeutic research, clinical and experimental, 1976, Volume: 20, Issue:1

    Topics: Acetaminophen; Adult; Aged; Body Temperature; Clinical Trials as Topic; Female; Fever; Humans; Male;

1976
Management of feverish children at home.
    BMJ (Clinical research ed.), 1992, Nov-07, Volume: 305, Issue:6862

    Topics: Acetaminophen; Baths; Child, Preschool; Clothing; Fever; Home Nursing; Humans; Infant; Random Alloca

1992
Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetaminophen in febrile children.
    Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:2

    Topics: Acetaminophen; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Fever; Humans; Ibu

1992
Antipyretic efficacy of ibuprofen vs acetaminophen.
    American journal of diseases of children (1960), 1992, Volume: 146, Issue:5

    Topics: Acetaminophen; Body Temperature; Child; Child, Preschool; Double-Blind Method; Female; Fever; Humans

1992
Comparison of multidose ibuprofen and acetaminophen therapy in febrile children.
    American journal of diseases of children (1960), 1992, Volume: 146, Issue:5

    Topics: Acetaminophen; Body Temperature; Child; Child, Preschool; Double-Blind Method; Drug Administration S

1992
Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories.
    Drugs under experimental and clinical research, 1992, Volume: 18, Issue:2

    Topics: Acetaminophen; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschoo

1992
Risks and benefits of paracetamol antipyresis in young children with fever of presumed viral origin.
    Lancet (London, England), 1991, Mar-09, Volume: 337, Issue:8741

    Topics: Acetaminophen; Acute Disease; Child; Child, Preschool; Double-Blind Method; Drug Administration Sche

1991
Treatment of childhood fevers.
    Lancet (London, England), 1991, Jun-01, Volume: 337, Issue:8753

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Culture; Fever; Hum

1991
Single-dose, placebo-controlled comparative study of ibuprofen and acetaminophen antipyresis in children.
    The Journal of pediatrics, 1991, Volume: 119, Issue:5

    Topics: Acetaminophen; Administration, Oral; Anti-Bacterial Agents; Body Temperature; Body Weight; Child; Ch

1991
Ibuprofen versus paracetamol for the treatment of fever in children.
    British journal of clinical practice. Supplement, 1990, Volume: 70

    Topics: Acetaminophen; Child; Child, Preschool; Fever; Humans; Ibuprofen; Infant; Research Design

1990
A double-blind comparison of ibuprofen and paracetamol in juvenile pyrexia.
    British journal of clinical practice. Supplement, 1990, Volume: 70

    Topics: Acetaminophen; Body Temperature; Child; Child, Preschool; Double-Blind Method; Drug Administration S

1990
A comparison of three methods of managing fever in the neurologic patient.
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 1990, Volume: 22, Issue:1

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Baths; Evaluation Studies as Topic; Female; Fever; Hu

1990
[Pharmacosurveillance of antipyretics. Evaluation of the risk-benefit ratio of a combination of paracetamol and sobrerol. Monitoring of 3501 ambulatory patients].
    La Clinica terapeutica, 1990, Feb-15, Volume: 132, Issue:3

    Topics: Acetaminophen; Adult; Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation; Dru

1990
Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.
    The Journal of infectious diseases, 1990, Volume: 162, Issue:6

    Topics: Acetaminophen; Adult; Antibodies, Viral; Aspirin; Common Cold; Double-Blind Method; Female; Fever; H

1990
Pharmacokinetics of paracetamol after cardiac surgery.
    Archives of disease in childhood, 1990, Volume: 65, Issue:9

    Topics: Acetaminophen; Administration, Rectal; Cardiac Surgical Procedures; Child; Child, Preschool; Fever;

1990
Comparative evaluation of the antipyretic efficacy of ibuprofen and paracetamol.
    Indian pediatrics, 1990, Volume: 27, Issue:8

    Topics: Acetaminophen; Child; Child, Preschool; Female; Fever; Humans; Ibuprofen; Infant; Male

1990
Longitudinal study of adverse reactions following diphtheria-tetanus-pertussis vaccine in infancy.
    Pediatrics, 1990, Volume: 85, Issue:3

    Topics: Acetaminophen; Age Factors; Antibody Formation; Diphtheria-Tetanus-Pertussis Vaccine; Erythema; Feve

1990
Efficacy of sponging vs acetaminophen for reduction of fever. Sponging Study Group.
    Pediatric emergency care, 1990, Volume: 6, Issue:1

    Topics: Acetaminophen; Baths; Body Temperature; Body Temperature Regulation; Child, Preschool; Combined Moda

1990
[Comparison of the antipyretic effect of a single dose of dipyrone, paracetamol and diclofenac resinate. A multicenter clinical trial].
    Medicina, 1989, Volume: 49, Issue:6

    Topics: Acetaminophen; Body Temperature; Child; Child, Preschool; Diclofenac; Dipyrone; Female; Fever; Human

1989
Ibuprofen, acetaminophen, and placebo treatment of febrile children.
    Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:1

    Topics: Acetaminophen; Administration, Oral; Adolescent; Child; Child, Preschool; Clinical Trials as Topic;

1989
Effect of prophylactic acetaminophen administration on reaction to DTP vaccination.
    Acta paediatrica Scandinavica, 1988, Volume: 77, Issue:5

    Topics: Acetaminophen; Clinical Trials as Topic; Diphtheria Toxoid; Double-Blind Method; Fever; Humans; Immu

1988
Acetaminophen prophylaxis of adverse reactions following vaccination of infants with diphtheria-pertussis-tetanus toxoids-polio vaccine.
    The Pediatric infectious disease journal, 1987, Volume: 6, Issue:8

    Topics: Acetaminophen; Body Temperature; Clinical Trials as Topic; Diphtheria Toxoid; Diphtheria-Tetanus-Per

1987
Fever response to acetaminophen in viral vs. bacterial infections.
    The Pediatric infectious disease journal, 1987, Volume: 6, Issue:12

    Topics: Acetaminophen; Adolescent; Bacterial Infections; Child; Child, Preschool; Clinical Trials as Topic;

1987
Antipyretic activity of ibuprofen and paracetamol in children with pyrexia.
    The British journal of clinical practice, 1985, Volume: 39, Issue:4

    Topics: Acetaminophen; Child; Child, Preschool; Clinical Trials as Topic; Female; Fever; Humans; Ibuprofen;

1985
Clinical experience and results of treatment with suprofen in pediatrics. 2nd communication: Use of suprofen suppositories as an antipyretic in children with fever due to acute infections/A single-blind controlled study of suprofen versus paracetamol.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:11

    Topics: Acetaminophen; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Child; Chil

1985
Antipyretic effect of tenoxicam and paracetamol in febrile children.
    Drugs under experimental and clinical research, 1985, Volume: 11, Issue:10

    Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Clinica

1985
A comparison of the antipyretic effect of acetaminophen and aspirin. Another approach to poison prevention.
    American journal of diseases of children (1960), 1972, Volume: 124, Issue:6

    Topics: Acetaminophen; Age Factors; Aspirin; Body Temperature; Child, Preschool; Clinical Trials as Topic; F

1972
[Use in the pediatric field of an antipyretic, hypno-sedative and analgesic combination].
    Minerva pediatrica, 1973, Feb-11, Volume: 25, Issue:4

    Topics: Acetaminophen; Analgesics; Benzoates; Child, Preschool; Clinical Trials as Topic; Drug Combinations;

1973
Study of antipyretic therapy in current use.
    Archives of disease in childhood, 1973, Volume: 48, Issue:4

    Topics: Acetaminophen; Aspirin; Body Temperature; Child, Preschool; Clinical Trials as Topic; Fever; Humans;

1973
A comparative evaluation of indomethacin, acetaminophen and placebo as antipyretic agents in children.
    Arthritis and rheumatism, 1968, Volume: 11, Issue:5

    Topics: Acetaminophen; Chemical Phenomena; Chemistry; Child; Clinical Trials as Topic; Fever; Humans; Indome

1968
Evaluation of sponging and of oral antipyretic therapy to reduce fever.
    The Journal of pediatrics, 1970, Volume: 77, Issue:5

    Topics: 1-Propanol; Acetaminophen; Baths; Child, Preschool; Fever; Humans; Infant; Placebos; Temperature; Ti

1970

Other Studies

426 other studies available for acetaminophen and Fever

ArticleYear
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atherosclerosis; Fever; Humans; Intramolecular Oxi

2008
Synthesis, biological evaluation and docking studies of novel benzopyranone congeners for their expected activity as anti-inflammatory, analgesic and antipyretic agents.
    Bioorganic & medicinal chemistry, 2009, Jul-15, Volume: 17, Issue:14

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Catalytic D

2009
Syntheses, characterization and evaluation of novel 2,6-diarylpiperidin-4-ones as potential analgesic-antipyretic agents.
    European journal of medicinal chemistry, 2014, Jul-23, Volume: 82

    Topics: Acetic Acid; Analgesics; Animals; Antipyretics; Body Temperature; Dose-Response Relationship, Drug;

2014
Synthesis, hepatotoxic evaluation and antipyretic activity of nitrate ester analogs of the acetaminophen derivative SCP-1.
    Bioorganic & medicinal chemistry letters, 2018, 12-15, Volume: 28, Issue:23-24

    Topics: Acetaminophen; Animals; Antipyretics; Chemical and Drug Induced Liver Injury; Crystallography, X-Ray

2018
Intravenous Versus Oral Acetaminophen Use in Febrile Neurocritical Care Patients.
    Therapeutic hypothermia and temperature management, 2022, Volume: 12, Issue:3

    Topics: Acetaminophen; Administration, Intravenous; Fever; Humans; Hypothermia, Induced; Ischemic Stroke; Re

2022
COVID Arm After Moderna Booster in Healthcare Worker: A Case Report.
    Acta medica Indonesiana, 2021, Volume: 53, Issue:3

    Topics: 2019-nCoV Vaccine mRNA-1273; Acetaminophen; Analgesics, Non-Narcotic; Biopsy; COVID-19; COVID-19 Vac

2021
Fever-Related Ventricular Fibrillation - Potential Adverse Effect of SARS-CoV-2 Vaccination in Patients With Brugada Syndrome.
    Circulation journal : official journal of the Japanese Circulation Society, 2022, Feb-25, Volume: 86, Issue:3

    Topics: Acetaminophen; Adult; Anti-Arrhythmia Agents; Antipyretics; Arrhythmias, Cardiac; Brugada Syndrome;

2022
Does immunosuppressive property of non-steroidal anti-inflammatory drugs (NSAIDs) reduce COVID-19 vaccine-induced systemic side effects?
    Drug discoveries & therapeutics, 2021, Nov-21, Volume: 15, Issue:5

    Topics: Acetaminophen; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; COVID-19 Vaccines; Fati

2021
Risk Factors for Intravenous Propacetamol-Induced Blood Pressure Drop in the Neurointensive Care Unit: A Retrospective Observational Study.
    Neurocritical care, 2022, Volume: 36, Issue:3

    Topics: Acetaminophen; Blood Pressure; Fever; Humans; Hypotension; Retrospective Studies; Risk Factors

2022
Investigations of the antipyretic effect and safety of Prasachandaeng, a traditional remedy from Thailand national list of essential medicines.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 147

    Topics: Acetaminophen; Animals; Antipyretics; Cytochrome P-450 CYP2E1; Disease Models, Animal; Dose-Response

2022
Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures.
    Epilepsia, 2022, Volume: 63, Issue:7

    Topics: Acetaminophen; Child; Diazepam; Fever; Humans; Infant; Prospective Studies; Recurrence; Seizures, Fe

2022
Recurrent vincristine-associated fever in a child with Wilms tumor.
    Cancer reports (Hoboken, N.J.), 2022, Volume: 5, Issue:10

    Topics: Acetaminophen; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dexamethason

2022
The attitudes and expectation of caregivers of febrile child receiving medical services: a multicenter survey in Thailand.
    Family practice, 2023, 03-28, Volume: 40, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Antipyretics; Attitude to Health; Caregivers; Child; Cross-Section

2023
Acetaminophen Versus Ibuprofen for Fever Reduction in the Pediatric Emergency Department.
    Clinical pediatrics, 2023, Volume: 62, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Therap

2023
Acetaminophen Versus Ibuprofen for Fever Reduction in the Pediatric Emergency Department.
    Clinical pediatrics, 2023, Volume: 62, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Therap

2023
Acetaminophen Versus Ibuprofen for Fever Reduction in the Pediatric Emergency Department.
    Clinical pediatrics, 2023, Volume: 62, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Therap

2023
Acetaminophen Versus Ibuprofen for Fever Reduction in the Pediatric Emergency Department.
    Clinical pediatrics, 2023, Volume: 62, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Therap

2023
Current perceptions and use of paracetamol in dogs among veterinary surgeons working in the United Kingdom.
    Veterinary medicine and science, 2023, Volume: 9, Issue:2

    Topics: Acetaminophen; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Fever; Humans; Uni

2023
Antipyretic and antinociceptive effects of methanolic extract of C. iria L. tuber.
    Journal of ethnopharmacology, 2024, Jan-10, Volume: 318, Issue:Pt A

    Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Antipyretics; Fever; Methanol; Mice; Plant Extracts

2024
Lack of evidence for a beneficial effect of antipyretic drugs.
    Acta paediatrica (Oslo, Norway : 1992), 2023, Volume: 112, Issue:10

    Topics: Acetaminophen; Antipyretics; Fever; Humans

2023
Are we confident that we all share a common understanding of discomfort in febrile children?
    Acta paediatrica (Oslo, Norway : 1992), 2023, Volume: 112, Issue:10

    Topics: Acetaminophen; Child; Fever; Humans

2023
Treatment of fever and associated symptoms in the emergency department: which drug to choose?
    European review for medical and pharmacological sciences, 2023, Volume: 27, Issue:15

    Topics: Acetaminophen; Adult; Aged; Bacteriophages; Emergency Service, Hospital; Fever; Humans; Ibuprofen; M

2023
Adverse events following immunization (AEFIs) with anti-meningococcus type B vaccine (4CMenB): Data of post-marketing active surveillance program. Apulia Region (Italy), 2019-2023.
    Vaccine, 2023, 11-22, Volume: 41, Issue:48

    Topics: Acetaminophen; Antibodies; Cross-Sectional Studies; Fever; Humans; Immunization; Infant; Italy; Meni

2023
Antipyretic Efficacy of Acetaminophen and Ibuprofen in Critically Ill Pediatric Patients.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2019, Volume: 20, Issue:8

    Topics: Acetaminophen; Antipyretics; Body Temperature; Child; Child, Preschool; Critical Illness; Female; Fe

2019
Reply to Acetaminophen Use and Stroke Risk.
    Journal of the American Geriatrics Society, 2019, Volume: 67, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Stroke

2019
Efficacy and safety of modified-release paracetamol for acute and chronic pain: a systematic review protocol.
    BMJ open, 2019, Oct-14, Volume: 9, Issue:10

    Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Australia; Child; Child, Preschool; Chron

2019
Prophylactic Paracetamol After Meningococcal B Vaccination Reduces Postvaccination Fever and Septic Screens in Hospitalized Preterm Infants.
    The Pediatric infectious disease journal, 2020, Volume: 39, Issue:1

    Topics: Acetaminophen; Female; Fever; Hospitalization; Humans; Infant; Infant, Newborn; Infant, Premature; M

2020
Antihyperthermic treatment decreases perihematomal hypodensity.
    Neurology, 2020, 04-21, Volume: 94, Issue:16

    Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Body Temperature; Cerebral Hemorrhage; Dipyron

2020
Antipyretics might occupy a narrow temporal position in aetiology of type 1 diabetes: Immunological and intestinal studies required.
    Medical hypotheses, 2020, Volume: 141

    Topics: Acetaminophen; Antipyretics; Autoimmune Diseases; Child, Preschool; Diabetes Mellitus, Type 1; Fever

2020
First case of focal epilepsy associated with SARS-coronavirus-2.
    Journal of medical virology, 2020, Volume: 92, Issue:10

    Topics: Acetaminophen; Acetylcysteine; Aged; Ambroxol; Anticonvulsants; Cough; COVID-19; COVID-19 Drug Treat

2020
Treating COVID-19 with colchicine in community healthcare setting.
    Clinical immunology (Orlando, Fla.), 2020, Volume: 217

    Topics: Acetaminophen; Anti-Inflammatory Agents; Azithromycin; Betacoronavirus; Cohort Studies; Colchicine;

2020
The use of ibuprofen to treat fever in COVID-19: A possible indirect association with worse outcome?
    Medical hypotheses, 2020, Volume: 144

    Topics: Acetaminophen; Antipyretics; COVID-19 Drug Treatment; Fever; Humans; Ibuprofen; Models, Theoretical;

2020
Ibuprofen use and clinical outcomes in COVID-19 patients.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020, Volume: 26, Issue:9

    Topics: Acetaminophen; Adult; Antipyretics; COVID-19; COVID-19 Drug Treatment; Female; Fever; Humans; Ibupro

2020
Safety and Feasibility of a Novel Transnasal Cooling Device to Induce Normothermia in Febrile Cerebrovascular Patients.
    Neurocritical care, 2021, Volume: 34, Issue:2

    Topics: Acetaminophen; Body Temperature; Cold Temperature; Feasibility Studies; Female; Fever; Humans; Hypot

2021
[Acetaminophen induced delayed-type urticaria and angioedema in a child].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2020, Aug-02, Volume: 58, Issue:8

    Topics: Acetaminophen; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Fever; Humans; Infant; Urticaria

2020
An assessment of parents' knowledge and awareness regarding paracetamol use in children: a cross-sectional study from Palestine.
    BMC public health, 2021, 02-18, Volume: 21, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Cross-Sectional Studies; Female; Fever; Health Knowl

2021
Paracetamol or ibuprofen for fever or pain in children under 2 years old.
    Journal of paediatrics and child health, 2021, Volume: 57, Issue:8

    Topics: Acetaminophen; Antipyretics; Child; Fever; Humans; Ibuprofen; Infant; Pain

2021
Appropriateness of Acetaminophen Dosing by Caregivers of Pediatric Patients Presenting to the Emergency Department at the University Pediatric Hospital in Puerto Rico.
    Puerto Rico health sciences journal, 2021, Volume: 40, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Caregivers; Child; Child, Preschool; Cross-Sectional

2021
Community use of paracetamol and ibuprofen in children with fever.
    Journal of paediatrics and child health, 2021, Volume: 57, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Fever; Humans; Ibuprofen; Prospective Studies

2021
Comparative Analysis of Single and Combined Antipyretics Using Patient-Generated Health Data: Retrospective Observational Study.
    JMIR mHealth and uHealth, 2021, 05-26, Volume: 9, Issue:5

    Topics: Acetaminophen; Antipyretics; Child; Fever; Humans; Mobile Applications; Retrospective Studies

2021
Initial experience of the safety and tolerability of the BNT162b2 (Pfizer-Bio-N-Tech) vaccine in extremely vulnerable children aged 12-15 years.
    Archives of disease in childhood, 2022, Volume: 107, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; BNT162 Vaccine; Child; Comorbidity; COVID-19; Fever;

2022
Severe polyarthralgia, high-grade fever, diffuse maculopapular rash on trunk and extremities · Dx?
    The Journal of family practice, 2017, Volume: 66, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Ankle; Anti-Inflammatory Agents; Arthralgia; Caribbe

2017
Haemodynamic changes with paracetamol in critically-ill children.
    Journal of critical care, 2017, Volume: 40

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Blood Pressure; Child; Child, Hospitaliz

2017
UK parents' attitudes towards meningococcal group B (MenB) vaccination: a qualitative analysis.
    BMJ open, 2017, 05-04, Volume: 7, Issue:4

    Topics: Acetaminophen; Adult; Anxiety; Cross-Sectional Studies; England; Evaluation Studies as Topic; Female

2017
Antipyretic potential of herbal coded formulation (Pyrexol).
    Pakistan journal of pharmaceutical sciences, 2017, Volume: 30, Issue:1

    Topics: Acetaminophen; Animals; Antipyretics; Body Temperature Regulation; Disease Models, Animal; Female; F

2017
Hemodynamic changes in patients with influenza A after propacetamol infusion in the emergency department.
    The American journal of emergency medicine, 2018, Volume: 36, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Pressure; Emergency Service, Hospital; Female;

2018
Medicine use practices in management of symptoms of acute upper respiratory tract infections in children (≤12 years) in Kampala city, Uganda.
    BMC public health, 2017, 09-21, Volume: 17, Issue:1

    Topics: Acetaminophen; Acute Disease; Adult; Amoxicillin; Anti-Infective Agents; Artemether, Lumefantrine Dr

2017
NBAS mutations cause acute liver failure: when acetaminophen is not a culprit.
    Italian journal of pediatrics, 2017, Sep-25, Volume: 43, Issue:1

    Topics: Acetaminophen; Diagnosis, Differential; Disease Progression; Fever; Genetic Predisposition to Diseas

2017
Antipyretic Medication Exposures Among Young Children Reported to US Poison Centers, 2000-2015.
    Clinical pediatrics, 2018, Volume: 57, Issue:3

    Topics: Acetaminophen; Age Distribution; Antipyretics; Child; Child, Preschool; Confidence Intervals; Databa

2018
The effect of antipyretics on immune response and fever following receipt of inactivated influenza vaccine in young children.
    Vaccine, 2017, 12-04, Volume: 35, Issue:48 Pt B

    Topics: Acetaminophen; Antibodies, Viral; Antipyretics; Child, Preschool; Female; Fever; Hemagglutination In

2017
Hemodynamic changes after propacetamol administration in patients with febrile UTI in the ED.
    The American journal of emergency medicine, 2018, Volume: 36, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Emergency

2018
The Effect of Acetaminophen on Temperature in Critically Ill Children: A Retrospective Analysis of Over 50,000 Doses.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2018, Volume: 19, Issue:3

    Topics: Acetaminophen; Antipyretics; Body Temperature; Child; Cohort Studies; Critical Illness; Fever; Human

2018
Effect of early natal supplementation of paracetamol on attenuation of exotoxin/endotoxin induced pyrexia and precipitation of autistic like features in albino rats.
    Inflammopharmacology, 2018, Volume: 26, Issue:4

    Topics: Acetaminophen; Animals; Animals, Newborn; Antipyretics; Autistic Disorder; Behavior, Animal; Diphthe

2018
Complex analyses on clinical information systems using restricted natural language querying to resolve time-event dependencies.
    Journal of biomedical informatics, 2018, Volume: 82

    Topics: Acetaminophen; Algorithms; Body Temperature; Brain Injuries, Traumatic; Data Collection; Data Scienc

2018
Intravenous acetaminophen for the treatment of intrapartum fever and resolution of fetal tachycardia: a novel use for an old medication.
    Clinical and experimental obstetrics & gynecology, 2017, Volume: 44, Issue:1

    Topics: Acetaminophen; Antipyretics; Female; Fetal Diseases; Fever; Humans; Infant, Newborn; Infusions, Intr

2017
Ibuprofen and Paracetamol: Acceptably Safe for All?
    Drug safety, 2018, Volume: 41, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Ibuprofen

2018
A Survey on Fever Monitoring and Management in Patients With Acute Brain Injury: The SUMMA Study.
    Journal of neurosurgical anesthesiology, 2019, Volume: 31, Issue:4

    Topics: Acetaminophen; Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Body Tem

2019
[Side Effects of Acetaminophen and their Management].
    Masui. The Japanese journal of anesthesiology, 2016, Volume: 65, Issue:7

    Topics: Acetaminophen; Aspirin; Chronic Pain; Cyclooxygenase 1; Fever; Humans; Pain Management; Reye Syndrom

2016
Short-term safety of 4CMenB vaccine during a mass meningococcal B vaccination campaign in Quebec, Canada.
    Vaccine, 2018, 12-18, Volume: 36, Issue:52

    Topics: Acetaminophen; Adolescent; Child; Child, Preschool; Female; Fever; Humans; Immunization Programs; Im

2018
Antipyretic effect of phytol, possibly via 5KIR-dependent COX-2 inhibition pathway.
    Inflammopharmacology, 2019, Volume: 27, Issue:4

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cyclooxygenase 1; Cyc

2019
Arthus Reaction.
    The Journal of emergency medicine, 2019, Volume: 56, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthus Reaction; Child; Cyproheptadine; Diphtheria-Tetanus-

2019
Feasibility and Safety of Transnasal High Flow Air to Reduce Core Body Temperature in Febrile Neurocritical Care Patients: A Pilot Study.
    Neurocritical care, 2019, Volume: 31, Issue:2

    Topics: Acetaminophen; Adult; Aged; Antipyretics; Body Temperature; Cerebral Hemorrhage; Cerebral Intraventr

2019
Paracetamol for dengue fever: no benefit and potential harm?
    The Lancet. Global health, 2019, Volume: 7, Issue:5

    Topics: Acetaminophen; Adult; Antipyretics; Dengue; Fever; Humans; Liver

2019
Phytochemical screening and antipyretic effects of hydroalcoholic extracts of selected medicinal plants of Rawalakot, Azad Jammu and Kashmir in albino rats.
    Pakistan journal of pharmaceutical sciences, 2019, Volume: 32, Issue:2

    Topics: Acetaminophen; Achillea; Animals; Antipyretics; Drug Evaluation, Preclinical; Female; Fever; Male; P

2019
Maternal fever during pregnancy and offspring attention deficit hyperactivity disorder.
    Scientific reports, 2019, 07-02, Volume: 9, Issue:1

    Topics: Acetaminophen; Adult; Attention Deficit Disorder with Hyperactivity; Child; Cohort Studies; Female;

2019
The investigation of possible roles of central 5-HT
    Inflammopharmacology, 2019, Volume: 27, Issue:6

    Topics: Acetaminophen; Animals; Antipyretics; Body Temperature; Disease Models, Animal; Fever; Interleukin-6

2019
Using health information technology to improve health care: emphasizing speed to value.
    Archives of internal medicine, 2012, Dec-10, Volume: 172, Issue:22

    Topics: Acetaminophen; Female; Fever; Humans; Inpatients; Liver Failure, Acute; Male

2012
Use of paracetamol in ischaemic stroke patients: evidence from VISTA.
    Acta neurologica Scandinavica, 2013, Volume: 128, Issue:3

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Brain Ischemia; Female; Fever; Hum

2013
Acetaminophen reduces lipopolysaccharide-induced fever by inhibiting cyclooxygenase-2.
    Neuropharmacology, 2013, Volume: 71

    Topics: Acetaminophen; Animals; Antipyretics; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; D

2013
The ability of a retrospective review of electronic health records to fully capture the frequency of supratherapeutic dosing of acetaminophen.
    JAMA internal medicine, 2013, Jun-10, Volume: 173, Issue:11

    Topics: Acetaminophen; Female; Fever; Humans; Inpatients; Liver Failure, Acute; Male

2013
The ability of a retrospective review of electronic health records to fully capture the frequency of supratherapeutic dosing of acetaminophen--reply.
    JAMA internal medicine, 2013, Jun-10, Volume: 173, Issue:11

    Topics: Acetaminophen; Female; Fever; Humans; Inpatients; Liver Failure, Acute; Male

2013
Temperature management in haematology patients with febrile neutropenia: a practice survey.
    The New Zealand medical journal, 2013, Apr-19, Volume: 126, Issue:1373

    Topics: Acetaminophen; Antipyretics; Cryotherapy; Fever; Hematology; Humans; Meperidine; Neutropenia; New Ze

2013
Management of children's fever by parents and caregivers: Practical measurement of functional health literacy.
    Journal of child health care : for professionals working with children in the hospital and community, 2014, Volume: 18, Issue:4

    Topics: Acetaminophen; Antipyretics; Australia; Caregivers; Child, Preschool; Female; Fever; Health Literacy

2014
Statistical significance of paracetamol administration in fetal and maternal body temperatures.
    European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 171, Issue:1

    Topics: Acetaminophen; Antipyretics; Body Temperature; Female; Fever; Humans; Obstetric Labor Complications;

2013
Parental language and dosing errors after discharge from the pediatric emergency department.
    Pediatric emergency care, 2013, Volume: 29, Issue:9

    Topics: Acetaminophen; Adult; Body Weight; Boston; Child; Child Health Services; Child, Preschool; Communica

2013
Authors' response.
    European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 171, Issue:1

    Topics: Acetaminophen; Antipyretics; Body Temperature; Female; Fever; Humans; Obstetric Labor Complications;

2013
Is fever treated more promptly than pain in the pediatric emergency department?
    The Journal of emergency medicine, 2014, Volume: 46, Issue:3

    Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Antipyretics; Child; Child, Presch

2014
Management of fever, hyperglycemia, and swallowing dysfunction following hospital admission for acute stroke in New South Wales, Australia.
    International journal of stroke : official journal of the International Stroke Society, 2014, Volume: 9, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Cohort Studies; Deglutition Disorders; Female;

2014
Diagnosis and management of temperature abnormality in ICUs: a EUROBACT investigators' survey.
    Critical care (London, England), 2013, Dec-10, Volume: 17, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Bacteremia; Clinical Protocols

2013
Adherence among Italian paediatricians to the Italian guidelines for the management of fever in children: a cross sectional survey.
    BMC pediatrics, 2013, Dec-18, Volume: 13

    Topics: Acetaminophen; Administration, Rectal; Antipyretics; Child; Cross-Sectional Studies; Fever; Guidelin

2013
Arsenic reduces the antipyretic activity of paracetamol in rats: modulation of brain COX-2 activity and CB₁ receptor expression.
    Environmental toxicology and pharmacology, 2014, Volume: 37, Issue:1

    Topics: Acetaminophen; Animals; Antipyretics; Arsenic; Brain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge

2014
[How to treat pediatric fever in 2013 with little evidence-based?].
    Revue medicale suisse, 2014, Jan-15, Volume: 10, Issue:412-413

    Topics: Acetaminophen; Child; Evidence-Based Practice; Fever; Humans; Ibuprofen; Seizures, Febrile

2014
Paracetamol induced Stevens-Johnson syndrome--toxic epidermal necrolysis overlap syndrome.
    International journal of dermatology, 2014, Volume: 53, Issue:8

    Topics: Acetaminophen; Antipyretics; Child; Female; Fever; Humans; Stevens-Johnson Syndrome

2014
Pyroglutamic acid-induced metabolic acidosis: a case report.
    Acta clinica Belgica, 2014, Volume: 69, Issue:3

    Topics: Acetaminophen; Acidosis; Anti-Bacterial Agents; Antipyretics; Female; Fever; Floxacillin; Humans; Mi

2014
Acute inhalation exposure to titanium ethanolate as a possible cause of metal fume fever.
    The international journal of occupational and environmental medicine, 2014, Volume: 5, Issue:2

    Topics: Acetaminophen; Adult; Aerosols; Analgesics, Non-Narcotic; Complex Mixtures; Dyspnea; Ethanol; Fever;

2014
Intravenous paracetamol for fever control in acute brain injury patients: cerebral and hemodynamic effects.
    Acta neurochirurgica, 2014, Volume: 156, Issue:10

    Topics: Acetaminophen; Adult; Aged; Female; Fever; Hemodynamics; Humans; Injections, Intravenous; Intracrani

2014
Acetaminophen-induced liver injury in a woman with febrile flare of systemic lupus erythematosus.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2014, Volume: 20, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; Fever;

2014
Cochrane in context: Combined and alternating paracetamol and ibuprofen therapy for febrile children.
    Evidence-based child health : a Cochrane review journal, 2014, Volume: 9, Issue:3

    Topics: Acetaminophen; Antipyretics; Child; Child, Preschool; Drug Therapy, Combination; Fever; Humans; Ibup

2014
Fever and the use of paracetamol during IL-2-based immunotherapy in metastatic melanoma.
    Cancer immunology, immunotherapy : CII, 2015, Volume: 64, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antineoplastic Combined Chemothera

2015
Kikuchi-Fujimoto disease: an unusual cause of neck swelling in pregnancy.
    BMJ case reports, 2015, Jan-20, Volume: 2015

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Biopsy, Fine-Needle; Diagnosi

2015
Acetaminophen & children. Why have pediatric dosage guidelines changed, and what does it mean in practice?
    Advance for NPs & PAs, 2011, Volume: 2, Issue:12

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Antipyretics; Child; Child, Preschool; Dose-Re

2011
Severe intrinsic acute kidney injury associated with therapeutic doses of acetaminophen.
    Pediatrics international : official journal of the Japan Pediatric Society, 2015, Volume: 57, Issue:2

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Child, Preschool; Female; Fever; Human

2015
A few pointers for judicious pediatric practice.
    Indian pediatrics, 2015, Volume: 52, Issue:8

    Topics: Acetaminophen; Child; Fever; Humans; Infant, Newborn; Patient Safety; Pediatrics; Resuscitation; Suc

2015
Non-Steroid Anti-Inflammatory Drugs Are Better than Acetaminophen on Fever Control at Acute Stage of Fracture.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Female; Fev

2015
Are Recommended Doses of Acetaminophen Effective for Children Aged 2 to 3 Years? A Pharmacokinetic Modeling Answer.
    Pediatric emergency care, 2016, Volume: 32, Issue:1

    Topics: Acetaminophen; Age Factors; Antipyretics; Child, Preschool; Female; Fever; Humans; Male; Models, Bio

2016
Acetaminophen administration in pediatric age: an observational prospective cross-sectional study.
    Italian journal of pediatrics, 2016, Feb-26, Volume: 42

    Topics: Acetaminophen; Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Emergency Service, Hosp

2016
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
    The New England journal of medicine, 2016, 03-31, Volume: 374, Issue:13

    Topics: Acetaminophen; Female; Fever; Humans; Infections; Male

2016
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
    The New England journal of medicine, 2016, 03-31, Volume: 374, Issue:13

    Topics: Acetaminophen; Female; Fever; Humans; Infections; Male

2016
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
    The New England journal of medicine, 2016, 03-31, Volume: 374, Issue:13

    Topics: Acetaminophen; Female; Fever; Humans; Infections; Male

2016
Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
    The New England journal of medicine, 2016, 03-31, Volume: 374, Issue:13

    Topics: Acetaminophen; Female; Fever; Humans; Infections; Male

2016
Clinically significant hemodynamic alterations after propacetamol injection in the emergency department: prevalence and risk factors.
    Internal and emergency medicine, 2017, Volume: 12, Issue:3

    Topics: Acetaminophen; Adult; Aged; Emergency Service, Hospital; Female; Fever; Hemodynamics; Humans; Hypote

2017
Enduring large use of acetaminophen suppositories for fever management in children: a national survey of French parents and healthcare professionals' practices.
    European journal of pediatrics, 2016, Volume: 175, Issue:7

    Topics: Acetaminophen; Administration, Rectal; Antipyretics; Child; Child, Preschool; Cross-Sectional Studie

2016
Paracetamol: pharmacology, prescribing and controversies.
    Archives of disease in childhood. Education and practice edition, 2016, Volume: 101, Issue:6

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Fever; Humans;

2016
Paracetamol-induced fixed drug eruption in a patient with recurrent fever and rash.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2016, Volume: 117, Issue:2

    Topics: Acetaminophen; Antipyretics; Autoimmunity; Child, Preschool; DNA Mutational Analysis; Drug Eruptions

2016
The pharma-fever that almost got away.
    Rhode Island medical journal (2013), 2016, Jul-01, Volume: 99, Issue:7

    Topics: Acetaminophen; Aged; Analgesics, Opioid; Antipyretics; Carcinoma, Non-Small-Cell Lung; Drug Overdose

2016
Paracetamol is no more likely to exacerbate asthma in children than ibuprofen, shows study.
    BMJ (Clinical research ed.), 2016, 08-17, Volume: 354

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Fev

2016
National modulators of symptomatic fever management in children: comparative analysis of survey data.
    Minerva pediatrica, 2018, Volume: 70, Issue:4

    Topics: Acetaminophen; Administration, Rectal; Antipyretics; Female; Fever; Humans; Ibuprofen; Infant; Italy

2018
Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness.
    The Annals of pharmacotherapy, 2017, Volume: 51, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Asthma; Child; Child, Preschool; Cross-Sectio

2017
Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study.
    Clinical pediatrics, 2017, Volume: 56, Issue:5

    Topics: Acetaminophen; Adult; Analgesics; Antipyretics; Caregivers; Cross-Sectional Studies; Culture; Female

2017
Parental beliefs and practices regarding childhood fever in Turkish primary care.
    Nigerian journal of clinical practice, 2017, Volume: 20, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Body Temperature; Caregivers; Child; Child, P

2017
Acetaminophen versus Ibuprofen in Mild Persistent Asthma.
    The New England journal of medicine, 2016, 11-24, Volume: 375, Issue:21

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Double-Blind Method; Fever; Humans;

2016
Acetaminophen versus Ibuprofen in Mild Persistent Asthma.
    The New England journal of medicine, 2016, 11-24, Volume: 375, Issue:21

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Double-Blind Method; Fever; Humans;

2016
Attitudes towards fever amongst UK paediatric intensive care staff.
    European journal of pediatrics, 2017, Volume: 176, Issue:3

    Topics: Acetaminophen; Antipyretics; Attitude of Health Personnel; Child; Cross-Sectional Studies; Fever; Hu

2017
Prenatal acetaminophen use and outcomes in children.
    American journal of obstetrics and gynecology, 2017, Volume: 216, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Fever; Humans; Neurodevelo

2017
[Myocardial infarction-like electrocardiogram in acute Hantavirus infection. Suspected secondary peri-myocarditis].
    Deutsche medizinische Wochenschrift (1946), 2008, Volume: 133, Issue:23

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antibodies, Viral; Back Pain; Diagnosis, Differentia

2008
Antipyretic treatment for feverish young children in primary care.
    BMJ (Clinical research ed.), 2008, Sep-02, Volume: 337

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Ibuprofen; Infant;

2008
Reactogenicity of infant whole cell pertussis combination vaccine compared with acellular pertussis vaccines with or without simultaneous pneumococcal vaccine in the Netherlands.
    Vaccine, 2008, Oct-29, Volume: 26, Issue:46

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Crying; Data Collection; Data Interpretation, Statistical;

2008
Combining paracetamol and ibuprofen for fever in children.
    BMJ (Clinical research ed.), 2008, Sep-10, Volume: 337

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Therapy, Combination; Fever; Humans; Ibuprofen

2008
Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme.
    Lancet (London, England), 2008, Sep-20, Volume: 372, Issue:9643

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Asthma; Child; Conjunctivitis; Cross-Sectional

2008
Ibuprofen increases soft tissue infections in children.
    BMJ (Clinical research ed.), 2008, Sep-23, Volume: 337

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Fever; Humans; Ibuprofen; Soft Tissue Infections

2008
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
    Pharmacotherapy, 2008, Volume: 28, Issue:10

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure;

2008
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
    Pharmacotherapy, 2008, Volume: 28, Issue:10

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure;

2008
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
    Pharmacotherapy, 2008, Volume: 28, Issue:10

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure;

2008
Effect of intravenous propacetamol on blood pressure in febrile critically ill patients.
    Pharmacotherapy, 2008, Volume: 28, Issue:10

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Blood Pressure;

2008
Paracetamol with ibuprofen: Ibuprofen is a marker of soft tissue infection.
    BMJ (Clinical research ed.), 2008, Oct-13, Volume: 337

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chickenpox; Child; Fever; Humans; Ibuprofen; Soft Tissue In

2008
. . . And which works better on fever--acetaminophen, ibuprofen, or both?
    Child health alert, 2008, Volume: 26

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child

2008
Prevention of febrile nonhemolytic and allergic transfusion reactions with pretransfusion medication: is this evidence-based medicine?
    Transfusion, 2008, Volume: 48, Issue:11

    Topics: Acetaminophen; Anemia, Hemolytic; Diphenhydramine; Evidence-Based Medicine; Fever; Humans; Leukocyte

2008
Paracetamol and fever management.
    The journal of the Royal Society for the Promotion of Health, 2008, Volume: 128, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Evidence-Based Medicine; Fever; Humans; Patient Education a

2008
Fever: to treat or not to treat?
    World journal of pediatrics : WJP, 2008, Volume: 4, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Therapy, Combination; Fever; Humans; Ibuprofen; Treatm

2008
Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract.
    Inflammopharmacology, 2009, Volume: 17, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Body Temperature; Chromatography, High Pressure Li

2009
[The practice guideline 'Children with fever' (second revision) from the Dutch College of General Practitioners; a response from the perspective of general practice].
    Nederlands tijdschrift voor geneeskunde, 2008, Dec-20, Volume: 152, Issue:51-52

    Topics: Acetaminophen; Child; Dehydration; Diagnosis, Differential; Family Practice; Fever; Humans; Netherla

2008
Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report.
    Acta paediatrica (Oslo, Norway : 1992), 2009, Volume: 98, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury

2009
Is giving acetaminophen rectally as good as giving it orally?
    Child health alert, 2009, Volume: 27

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Child; Fever; Humans

2009
Pyrexia after transcranial surgery for Pfeiffer syndrome.
    The Journal of craniofacial surgery, 2009, Volume: 20, Issue:2

    Topics: Acetaminophen; Acrocephalosyndactylia; Age Factors; Analgesics, Non-Narcotic; Body Temperature; Chil

2009
Characterization and pharmacological evaluation of febrile response on zymosan-induced arthritis in rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Body Temperature; Celecox

2009
Hyperthermic effects of Durio zibethinus and its interaction with paracetamol.
    Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:10

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Asia, Southeastern; Blood Pr

2008
Acute, reversible nonoliguric renal failure in two children associated with analgesic-antipyretic drugs.
    Pediatric emergency care, 2009, Volume: 25, Issue:4

    Topics: Abdominal Pain; Acetaminophen; Acute Kidney Injury; Adolescent; Analgesics, Non-Narcotic; Child; Deh

2009
Ethnic differences in parental perceptions and management of childhood fever.
    Clinical pediatrics, 2010, Volume: 49, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Black or African American; Body Temperature; Child; Child,

2010
Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica.
    Inflammopharmacology, 2009, Volume: 17, Issue:4

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Cucurbitacea

2009
Potential benefit of paracetamol administration in adult-onset Still's disease.
    Polskie Archiwum Medycyny Wewnetrznej, 2009, Volume: 119, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Therapy, Combination; Fever; Humans; Immunosuppressive

2009
Acetaminophen has limited antipyretic activity in critically ill patients.
    Journal of critical care, 2010, Volume: 25, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Critical Care; Critical Illness; Female;

2010
Management of fever in children: summary of the Italian Pediatric Society guidelines.
    Clinical therapeutics, 2009, Volume: 31, Issue:8

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Axilla; Body Temperature; Body Weight; Child;

2009
The yin and yang of paracetamol and paediatric immunisations.
    Lancet (London, England), 2009, Oct-17, Volume: 374, Issue:9698

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Fever; Humans; Immunity, Active; Mass Vaccination

2009
Renal colic in adults: NSAIDs and morphine are effective for pain relief.
    Prescrire international, 2009, Volume: 18, Issue:103

    Topics: Acetaminophen; Adult; Analgesia; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Clinic

2009
A/H1N1 flu pandemic. Fever as nature's engine?
    BMJ (Clinical research ed.), 2009, Dec-31, Volume: 339

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Fever; Humans; Influenza A Virus, H1N1 Su

2009
[44 year old gardener with lower back pain, myalgia and fever].
    Praxis, 2010, Jan-20, Volume: 99, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Analgesics, Non-Narcotic; Child; Clinical Trials as T

2010
Adolescents with asthma or atopic eczema have more febrile days in early childhood: a possible explanation for the connection between paracetamol and asthma?
    The Journal of allergy and clinical immunology, 2010, Volume: 125, Issue:3

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Asthma; Child; Dermatitis, Atopic; Fever; Human

2010
Antipyretic and antinociceptive properties of Mentha longifolia Huds. (Lamiaceae) leaf aqueous extract in rats and mice.
    Methods and findings in experimental and clinical pharmacology, 2009, Volume: 31, Issue:10

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Dose-Response

2009
Paracetamol for feverish children: parental motives and experiences.
    Scandinavian journal of primary health care, 2010, Volume: 28, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Child; Cross-Sectional Studies; Drug Utilization; Ed

2010
Can autism be triggered by acetaminophen activation of the endocannabinoid system?
    Acta neurobiologiae experimentalis, 2010, Volume: 70, Issue:2

    Topics: Acetaminophen; Autistic Disorder; Cannabinoid Receptor Modulators; Child; Child, Preschool; Endocann

2010
Paracetamol induced skin blood flow and blood pressure changes in febrile intensive care patients: An observational study.
    Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, 2010, Volume: 23, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; APACHE; Blood Flow Velocity; Blood Pr

2010
Paracetamol induced skin blood flow and blood pressure changes in febrile intensive care patients: An observational study.
    Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, 2010, Volume: 23, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; APACHE; Blood Flow Velocity; Blood Pr

2010
Paracetamol induced skin blood flow and blood pressure changes in febrile intensive care patients: An observational study.
    Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, 2010, Volume: 23, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; APACHE; Blood Flow Velocity; Blood Pr

2010
Paracetamol induced skin blood flow and blood pressure changes in febrile intensive care patients: An observational study.
    Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, 2010, Volume: 23, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; APACHE; Blood Flow Velocity; Blood Pr

2010
Treatment of pediatric fever: Are acetaminophen and ibuprofen equivalent?
    Canadian family physician Medecin de famille canadien, 2010, Volume: 56, Issue:8

    Topics: Acetaminophen; Antipyretics; Child; Child, Preschool; Family Practice; Fever; Humans; Ibuprofen; Inf

2010
An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study.
    Journal of neurology, 2011, Volume: 258, Issue:2

    Topics: Acetaminophen; Aged; Antipyretics; Female; Fever; Humans; Male; Multicenter Studies as Topic; Random

2011
Respiratory tract infections and not paracetamol medication during infancy are associated with asthma development in childhood.
    The Journal of allergy and clinical immunology, 2010, Volume: 126, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Child, Preschool; Fever; Humans; Infant; Inf

2010
Clinical management of fever by nurses: doing what works.
    Journal of advanced nursing, 2011, Volume: 67, Issue:2

    Topics: Acetaminophen; Acute Disease; Adult; Child; Clinical Competence; Decision Making; Evidence-Based Nur

2011
Pediatric rash and joint pain: a case review.
    Journal of emergency nursing, 2010, Volume: 36, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Ankle Joint; Anti-Bacterial Agents; Arthralgia; Ceftriaxone

2010
Does intravenous paracetamol administration affect body temperature in neonates?
    Archives of disease in childhood, 2011, Volume: 96, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Birth Weight; Body Temperature; Cohort Studies; Drug Admini

2011
Standardized antipyretic treatment in stroke: a pilot study.
    Cerebrovascular diseases (Basel, Switzerland), 2011, Volume: 31, Issue:4

    Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Body Temperature Regulation; Case-Control Stud

2011
Effective fever control in acute stroke: still wanted!
    Cerebrovascular diseases (Basel, Switzerland), 2011, Volume: 31, Issue:4

    Topics: Acetaminophen; Antipyretics; Body Temperature Regulation; Combined Modality Therapy; Dipyrone; Fever

2011
Parental administration of antipyretics to children with upper respiratory tract infections without consultation with a physician.
    Croatian medical journal, 2011, Volume: 52, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Antipyretics; Child; Child Care; Child Day Care Centers; Child, Pr

2011
The persistence of drug-induced fever by teicoplanin--a case report.
    International journal of clinical pharmacology and therapeutics, 2011, Volume: 49, Issue:5

    Topics: Acetaminophen; Anti-Bacterial Agents; Antipyretics; Cardiomyopathy, Dilated; Fever; Half-Life; Heart

2011
Knowledge of using acetaminophen syrup and comprehension of written medication instruction among caregivers with febrile children.
    Journal of clinical nursing, 2012, Volume: 21, Issue:1-2

    Topics: Acetaminophen; Administration, Oral; Adult; Caregivers; Child; Child, Preschool; Cross-Sectional Stu

2012
Hypotension with acetaminophen--maybe there is a different mechanism.
    Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, 2011, Volume: 24, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Flow Velocity; Blood Pressure; Female; Fever; Humans;

2011
Effects of high-dose paracetamol on blood pressure in acute stroke.
    Acta neurologica Scandinavica, 2012, Volume: 125, Issue:4

    Topics: Acetaminophen; Aged; Aged, 80 and over; Antipyretics; Blood Pressure; Blood Pressure Determination;

2012
A survey of teething beliefs and related practices among child healthcare workers in Ile-Ife, Nigeria.
    Oral health & preventive dentistry, 2011, Volume: 9, Issue:2

    Topics: Acetaminophen; Antipyretics; Attitude of Health Personnel; Child Health Services; Cross-Sectional St

2011
OFIRMEV: a recently introduced drug.
    Journal of pediatric nursing, 2011, Volume: 26, Issue:5

    Topics: Acetaminophen; Acute Pain; Analgesics; Antipyretics; Clinical Trials as Topic; Drug Approval; Fever;

2011
Clinical and demographic factors associated with antipyretic use in gram-negative severe sepsis and septic shock.
    The Annals of pharmacotherapy, 2011, Volume: 45, Issue:10

    Topics: Academic Medical Centers; Acetaminophen; Adult; Aged; Antipyretics; Bacteremia; Cohort Studies; Fema

2011
Antipyretic therapy for influenza infection--benefit or harm?
    The New Zealand medical journal, 2011, Jul-08, Volume: 124, Issue:1338

    Topics: Acetaminophen; Adult; Animals; Antipyretics; Child; Fever; Humans; Ibuprofen; Influenza, Human; Mice

2011
Fever and antipyresis in infection.
    The Medical journal of Australia, 2011, Oct-17, Volume: 195, Issue:8

    Topics: Acetaminophen; Antipyretics; Fever; Humans; Immunity, Innate; Infections

2011
Fever control in the NICU: is there still a simpler and cheaper solution?
    Neurocritical care, 2011, Volume: 15, Issue:3

    Topics: Acetaminophen; Antipyretics; Fever; Humans; Ibuprofen; Intensive Care Units; Intracranial Hemorrhage

2011
[Does paracetamol improve recovery after stroke?].
    Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155, Issue:46

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Fever; Hum

2011
A survey of fever management for febrile intensive care patients without neurological injury.
    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2011, Volume: 13, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Attitude of Health Personnel; Critical Illness; Fever; Heal

2011
Assessment of the safety and feasibility of administering anti-pyretic therapy in critically ill adults: study protocol of a randomized trial.
    BMC research notes, 2012, Mar-16, Volume: 5

    Topics: Acetaminophen; Adolescent; Adult; Aged; Alberta; Antipyretics; Body Temperature; Critical Illness; D

2012
[Hemodynamic and antipyretic effects of paracetamol, metamizol and dexketoprofen in critical patients].
    Medicina intensiva, 2012, Volume: 36, Issue:9

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics

2012
Analgesic and antipyretic activities of ethanol extract of Stereospermum suaveolens.
    Journal of dietary supplements, 2010, Volume: 7, Issue:2

    Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Antipyretics; Behavior, Animal; Bignoniaceae; Disea

2010
AAP reports on the use of antipyretics for fever in children.
    American family physician, 2012, Mar-01, Volume: 85, Issue:5

    Topics: Acetaminophen; Antipyretics; Child; Drug Therapy, Combination; Fever; Humans; Ibuprofen; Practice Gu

2012
[Paracetamol or NSAID for relief treatment in febrile children].
    Ugeskrift for laeger, 2012, Apr-30, Volume: 174, Issue:18

    Topics: Acetaminophen; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Child; D

2012
[Ibuprofen is more effective than paracetamol in lowering the temperature in febrile children].
    Ugeskrift for laeger, 2012, Apr-30, Volume: 174, Issue:18

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Child; Drug Therapy, Combination; Fever; Huma

2012
Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant.
    BMC complementary and alternative medicine, 2012, May-02, Volume: 12

    Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Behavior, A

2012
Alternating acetaminophen and ibuprofen for pain in children.
    Canadian family physician Medecin de famille canadien, 2012, Volume: 58, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres

2012
Update of the 2009 Italian Pediatric Society Guidelines about management of fever in children.
    Clinical therapeutics, 2012, Volume: 34, Issue:7

    Topics: Acetaminophen; Age Factors; Antipyretics; Axilla; Body Temperature; Child; Child, Preschool; Fever;

2012
Knowledge of Iranian general practitioners for acetaminophen dosing in children.
    JPMA. The Journal of the Pakistan Medical Association, 2012, Volume: 62, Issue:3 Suppl 2

    Topics: Acetaminophen; Adult; Antipyretics; Child, Preschool; Cross-Sectional Studies; Female; Fever; Genera

2012
Paracetamol use (and/or misuse) in children in Enugu, South-East, Nigeria.
    BMC pediatrics, 2012, Jul-19, Volume: 12

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Caregivers; Child; Child, Preschool; Dru

2012
Early antipyretic exposure does not increase mortality in patients with gram-negative severe sepsis: a retrospective cohort study.
    Internal and emergency medicine, 2012, Volume: 7, Issue:5

    Topics: Acetaminophen; Adult; Aged; Antipyretics; Female; Fever; Gram-Negative Bacterial Infections; Hospita

2012
The HEAT trial: a protocol for a multicentre randomised placebo-controlled trial of IV paracetamol in ICU patients with fever and infection.
    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2012, Volume: 14, Issue:4

    Topics: Acetaminophen; Administration, Intravenous; Adult; Antipyretics; Clinical Trials, Phase II as Topic;

2012
Symptom to door interval in febrile neutropenia: perspective in India.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013, Volume: 21, Issue:5

    Topics: Acetaminophen; Antipyretics; Bacterial Infections; Child; Child, Preschool; Female; Fever; Hospitali

2013
The majority of sick children receive paracetamol during the winter.
    Danish medical journal, 2012, Volume: 59, Issue:12

    Topics: Acetaminophen; Antipyretics; Cohort Studies; Cold Temperature; Denmark; Female; Fever; Follow-Up Stu

2012
Non-prescription medicines for pain and fever--a comparison of recommendations and counseling from staff in pharmacy and general sales stores.
    Health policy (Amsterdam, Netherlands), 2013, Volume: 110, Issue:1

    Topics: Acetaminophen; Analgesics; Antipyretics; Aspirin; Child; Commerce; Contraindications; Counseling; Fe

2013
Effects on fetal and maternal temperatures of paracetamol administration during labour: a case-control study.
    European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 168, Issue:2

    Topics: Acetaminophen; Adult; Algorithms; Antipyretics; Axilla; Body Temperature; Case-Control Studies; Coho

2013
Supratherapeutic dosing of acetaminophen among hospitalized patients.
    Archives of internal medicine, 2012, Dec-10, Volume: 172, Issue:22

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Confiden

2012
Intramuscular injection of propacetamol in a neonate.
    Archives of disease in childhood. Fetal and neonatal edition, 2002, Volume: 87, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Infant, Newborn; Injections, Intramuscular

2002
Body temperature in acute stroke.
    Stroke, 2002, Volume: 33, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Body Temperature; Disease Progression; Fever; Huma

2002
Short report: parental knowledge of rectal acetaminophen.
    Canadian family physician Medecin de famille canadien, 2002, Volume: 48

    Topics: Acetaminophen; Administration, Rectal; Adolescent; Adult; Child; Child, Preschool; Female; Fever; He

2002
Antipyretic effect of nimesulide and paracetamol in children.
    Indian pediatrics, 2002, Volume: 39, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Huma

2002
Prehospital use of paracetamol among children attending the accident and emergency department.
    Emergency medicine journal : EMJ, 2003, Volume: 20, Issue:1

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Cohort Studies; Emerge

2003
Evaluation of antipyretic activity of leaf extracts of Mallotus peltatus (Geist) Muell. arg. var acuminatus: a folk medicine.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2002, Volume: 9, Issue:8

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Body Temperature; Dose-Respo

2002
Evaluation of anti-pyretic potential of Ficus racemosa bark.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2002, Volume: 9, Issue:8

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Body Temperature; Dose-Respo

2002
Nimesulide vs. paracetamol: this trial needs to stand trial.
    Indian pediatrics, 2003, Volume: 40, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Hosp

2003
Evaluation of antipyretic potential of Cleome viscosa Linn. (Capparidaceae) extract in rats.
    Journal of ethnopharmacology, 2003, Volume: 87, Issue:1

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Body Temperature; Cleome; Do

2003
Paracetamol is the drug of choice for childhood pain and fever.
    Journal of the Irish Dental Association, 2003, Volume: 49, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Infant; Pain

2003
[RECTAL USE OF NAPA AS ANTIPYRETIC IN PEDIATRICS].
    Medicina, 1964, Aug-25, Volume: 44

    Topics: Acetaminophen; Antipyretics; Bronchitis; Child; Drug Therapy; Fever; Gastroenteritis; Humans; Infant

1964
Paracetamol for injection: new formulation. New formulation: why so widely used?
    Prescrire international, 2003, Volume: 12, Issue:67

    Topics: Acetaminophen; Adult; Child; Clinical Trials as Topic; Drug Approval; Fever; France; Humans; Infusio

2003
Time to counter 'fever phobia'!
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2003, Volume: 53, Issue:488

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Attitude to Health; Child; Fear; Fever; Humans; Parents

2003
Childhood illnesses and the use of paracetamol (acetaminophen): a qualitative study of parents' management of common childhood illnesses.
    Family practice, 2003, Volume: 20, Issue:6

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Attitude to Health; Child, Preschool; Family; Female

2003
Fever phobia revisited.
    Archives of disease in childhood, 2004, Volume: 89, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Drug Therapy, Combination; Fever; Humans;

2004
Antipyretic effect of acetaminophen by inhibition of glutamate release after staphylococcal enterotoxin A fever in rabbits.
    Neuroscience letters, 2004, Jan-23, Volume: 355, Issue:1-2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Body Temperature; Disease Models, Animal; Dose-Res

2004
Underdosing of acetaminophen by parents and emergency department utilization.
    Pediatric emergency care, 2004, Volume: 20, Issue:2

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Cross-Sectional Studie

2004
Severe traumatic head injury in adults: which patients are at risk of early hyperthermia?
    Intensive care medicine, 2004, Volume: 30, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Body Temperature; Brain Injuries; Female; Fever; Hum

2004
Acetaminophen dose accuracy and pediatric emergency care.
    Pediatric emergency care, 2004, Volume: 20, Issue:5

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesics, Non-Narcotic; Anti-Inflamma

2004
[The use of paracetamol and antibiotics among preschool children].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2004, Jun-17, Volume: 124, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Infective Agents; Bacterial Infections; Child, Prescho

2004
[Paracetamol to preschool children--indications and cultural background].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2004, Aug-26, Volume: 124, Issue:16

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Attitude to Health; Child, Preschool; Cultural Characterist

2004
Febrile nonhemolytic transfusion reactions. Management by premedication and cost implications in adult patients.
    Archives of pathology & laboratory medicine, 2004, Volume: 128, Issue:9

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Transfusion; Costs and Cost Analysis; Fever; H

2004
Ibuprofen or acetaminophen in children? As the debate continues, the evidence may favor ibuprofen.
    The American journal of nursing, 2004, Volume: 104, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Huma

2004
Reduction of body temperature with paracetamol in patients with acute stroke: randomised clinical trials are needed.
    Cerebrovascular diseases (Basel, Switzerland), 2004, Volume: 18, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Fever; Hu

2004
Hypothermia following fever.
    Archives of disease in childhood, 2004, Volume: 89, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Fever; Humans; Hypothermia; Ibuprofen; Infant

2004
Fever management: paediatric nurses' knowledge, attitudes and influencing factors.
    Journal of advanced nursing, 2005, Volume: 49, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Attitude of Health Personnel; Child; Cross-Sectional

2005
The use of folk remedies among children in an urban black community: remedies for fever, colic, and teething.
    Pediatrics, 2005, Volume: 115, Issue:3

    Topics: 2-Propanol; Acetaminophen; Adolescent; Adult; Age Factors; Anesthetics, Local; Baths; Benzocaine; Bl

2005
[New solution of simultaneous equations in spectrophotometry for the determination of aspirin and acetaminophen in xiaoer tuishao pian].
    Guang pu xue yu guang pu fen xi = Guang pu, 1999, Volume: 19, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Fever; Spectrophotometry

1999
Fever control in septic shock: beneficial or harmful?
    Shock (Augusta, Ga.), 2005, Volume: 23, Issue:6

    Topics: Acetaminophen; Animals; Body Temperature; Body Weight; Female; Fever; HSP70 Heat-Shock Proteins; Iso

2005
Paracetamol/acetaminophen-induced fever and malaise in a juvenile patient.
    Journal of pain and symptom management, 2005, Volume: 29, Issue:5

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Arthralgia; Female; Fever; Humans; Knee Joint

2005
[Aspirin, paracetamol, ibuprofen: analgesics in the family medicine cabinet].
    Revue de l'infirmiere, 2005, Issue:110

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Contraind

2005
Fever in term labour.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2005, Volume: 27, Issue:3

    Topics: Acetaminophen; Amniotic Fluid; Analgesia, Epidural; Female; Fever; Humans; Intensive Care, Neonatal;

2005
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:1

    Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Analgesics, Non-Narcotic; Antineoplastic Comb

2005
[Familial use of ibuprofen in febrile children: a prospective study in the emergency room of an hospital in Lille].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2005, Volume: 12, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child;

2005
PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial [ISCRTN 74418480].
    BMC cardiovascular disorders, 2005, Aug-19, Volume: 5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Clinical Protocols; Double-Blind Method;

2005
Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children.
    British journal of haematology, 2005, Volume: 130, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Allergic Agents; Blood Component Removal; Blood Compon

2005
Antipyretics and delirious behavior during febrile illness.
    Pediatrics international : official journal of the Japan Pediatric Society, 2006, Volume: 48, Issue:1

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Delirium; Diclofenac;

2006
Use and misuse of aspirin in rural Ethiopia.
    East African medical journal, 2006, Volume: 83, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Child; Cross-Sectional Studies; Ethiopia; Female; F

2006
A Friday afternoon case of apparent anti-glomerular basement nephritis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2006, Volume: 21, Issue:8

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Animals; Anti-Glomerular Basement Membrane Disease;

2006
Immunizations. Can fever-reducers prevent redness from DTP shots?
    Child health alert, 2006, Volume: 24

    Topics: Acetaminophen; Anti-Inflammatory Agents; Child; Diphtheria-Tetanus-Pertussis Vaccine; Drug Eruptions

2006
[Change in habits among the population in the management of childhood fever].
    Anales de pediatria (Barcelona, Spain : 2003), 2006, Volume: 64, Issue:5

    Topics: Acetaminophen; Child; Child, Preschool; Fever; Habits; Humans; Ibuprofen; Infant

2006
The effects of a complex homeopathic medicine compared with acetaminophen in the symptomatic treatment of acute febrile infections in children: an observational study.
    Explore (New York, N.Y.), 2005, Volume: 1, Issue:1

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analysis of Variance; Body Temperature; Chil

2005
Antipyretic drugs for children.
    BMJ (Clinical research ed.), 2006, Jul-01, Volume: 333, Issue:7557

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Combinations; Fever; Humans; Ibuprofen

2006
Alternating acetaminophen and ibuprofen in children may cause parental confusion and is dangerous.
    Archives of pediatrics & adolescent medicine, 2006, Volume: 160, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Confusion; Drug Administration Sch

2006
Concerns over alternating acetaminophen and ibuprofen for fever.
    Archives of pediatrics & adolescent medicine, 2006, Volume: 160, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Confusion; Drug Therapy, Combination; Fever; Humans;

2006
Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study.
    Clinical therapeutics, 2006, Volume: 28, Issue:5

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid

2006
Synthesis of new chemical entities from paracetamol and NSAIDs with improved pharmacodynamic profile.
    Bioorganic & medicinal chemistry, 2006, Dec-15, Volume: 14, Issue:24

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroida

2006
Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes.
    Acta tropica, 2006, Volume: 99, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antimalarials; Child, Preschool; Chloroquine; Cyto

2006
Severity of illness and the use of paracetamol in febrile preschool children; a case simulation study of parents' assessments.
    Family practice, 2006, Volume: 23, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Appetite; Body Temperature; Child, Preschool; Decision Maki

2006
Fulminant hepatic failure and paracetamol overuse with therapeutic intent in febrile children.
    Indian journal of pediatrics, 2006, Volume: 73, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Case-Control Studies; Child; Child, Preschool; Drug Overdos

2006
Natural course of fever during influenza virus infection in children.
    Clinical pediatrics, 2007, Volume: 46, Issue:1

    Topics: Acetaminophen; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Child; Female; Fever;

2007
Tramadol infusion for the pain management in sickle cell disease: a case report.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:1

    Topics: Abdominal Pain; Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Ch

2007
Fever after subarachnoid hemorrhage: risk factors and impact on outcome.
    Neurology, 2007, Mar-27, Volume: 68, Issue:13

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Body Temperature; Brain; Cerebral Hemorrhage; Cognition Dis

2007
Alternating antipyretics for fever reduction in children: an unfounded practice passed down to parents from pediatricians.
    Clinical pediatrics, 2007, Volume: 46, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Drug Administration Schedule; Fever; Heal

2007
Dipyrone and acetaminophen: correct dosing by parents?
    Sao Paulo medical journal = Revista paulista de medicina, 2007, Jan-04, Volume: 125, Issue:1

    Topics: Acetaminophen; Adult; Age Distribution; Anti-Inflammatory Agents, Non-Steroidal; Brazil; Dipyrone; D

2007
The time course and determinants of temperature within the first 48 h after ischaemic stroke.
    Cerebrovascular diseases (Basel, Switzerland), 2007, Volume: 24, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Bacterial Infec

2007
Antipyretic drug use in children in French office based medical practice.
    Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:7

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Aspirin; Child; Child, Preschool; Drug Therapy

2007
Preoptic nitric oxide attenuates endotoxic fever in guinea pigs by inhibiting the POA release of norepinephrine.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 293, Issue:3

    Topics: Acetaminophen; Adrenergic alpha-Antagonists; Animals; Body Temperature; Catheterization; Cyclooxygen

2007
Preoptic norepinephrine mediates the febrile response of guinea pigs to lipopolysaccharide.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 293, Issue:3

    Topics: Acetaminophen; Adrenergic alpha-Antagonists; Animals; Body Temperature; Catheterization; Cyclooxygen

2007
Over-the-counter medication use for childhood fever: a cross-sectional study of Australian parents.
    Journal of paediatrics and child health, 2007, Volume: 43, Issue:9

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Child, Preschool; Cross-Sectional Studies; Female; F

2007
Simultaneous sudden infant death syndrome.
    Journal of forensic and legal medicine, 2007, Volume: 14, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Brain; Diphtheria-Tetanus-Pertussis Vaccine; Female; Fever;

2007
Alternating acetaminophen with ibuprofen for fever: is this a problem?
    Pediatric annals, 2007, Volume: 36, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Drug Therapy, Combination; Fever; Humans;

2007
Acetaminophen for temperature reduction in acute stroke: potential but unproven benefits.
    Stroke, 2007, Volume: 38, Issue:11

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Body Temperature; Clinical Trials as Topic;

2007
Question from the clinician: alternating acetaminophen and ibuprofen in the treatment of fever.
    Pediatrics in review, 2007, Volume: 28, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Drug Administration Schedule; Drug Therapy, Combinat

2007
Antipyretic treatment of noninfectious fever in children with severe traumatic brain injury.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2008, Volume: 24, Issue:4

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Brain Injuries; Child; Child, Preschool; Dose-

2008
[Chikungunya: fever and joint pains after vacation in a tropical area].
    Deutsche medizinische Wochenschrift (1946), 2008, Volume: 133, Issue:9

    Topics: Acetaminophen; Adult; Alphavirus Infections; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infl

2008
A 2-year-old boy with fever and altered mental status.
    Pediatric annals, 2008, Volume: 37, Issue:2

    Topics: Acetaminophen; Child, Preschool; Contraindications; Diagnosis, Differential; Fever; Humans; Intensiv

2008
When the child has a fever.
    Drug and therapeutics bulletin, 2008, Volume: 46, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Diagnosis, Differential; Fever; Humans; Ibuprofen; P

2008
Recurrent fever, chills, and arthralgia with local anesthetics containing epinephrine-metabisulfite.
    Journal of clinical anesthesia, 2008, Volume: 20, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Arthralgia; Carticaine; Chills;

2008
Clinical comparison of three antipyretic agents.
    American journal of diseases of children (1960), 1967, Volume: 114, Issue:3

    Topics: Acetaminophen; Aspirin; Body Temperature; Child, Preschool; Female; Fever; Humans; Infant; Male; Sal

1967
Hyperpyrexia, allergic-type response and death occurring with low-dose bleomycin administration.
    Oncology, 1980, Volume: 37, Issue:5

    Topics: Acetaminophen; Aged; Bleomycin; Dexamethasone; Dose-Response Relationship, Drug; Drug Hypersensitivi

1980
Parents' conception of their use of over-the-counter medicines.
    Clinical pediatrics, 1982, Volume: 21, Issue:5

    Topics: Acetaminophen; Aspirin; Child, Preschool; Fever; Humans; Infant; Infant, Newborn; Nasal Decongestant

1982
[Paracetamol in oral solution: effectiveness against fever and tolerance in children with measles (author's transl)].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1982, Mar-18, Volume: 58, Issue:11

    Topics: Acetaminophen; Administration, Oral; Child; Child, Preschool; Female; Fever; Humans; Male; Measles;

1982
Cold comfort for hot children.
    British medical journal (Clinical research ed.), 1983, Apr-09, Volume: 286, Issue:6372

    Topics: Acetaminophen; Aspirin; Child; Child, Preschool; Fever; Humans; Infant; Reye Syndrome

1983
Comparative study of the antipyretic effect of ibuprofen (oral suspension) and paracetamol (suppositories) in paediatrics.
    The Journal of international medical research, 1984, Volume: 12, Issue:4

    Topics: Acetaminophen; Administration, Oral; Body Temperature; Child; Child, Preschool; Female; Fever; Human

1984
Fever therapy failure.
    Pediatrics, 1984, Volume: 74, Issue:5

    Topics: Acetaminophen; Child; Fever; Humans

1984
Pediatric dosing of acetaminophen.
    Pediatric pharmacology (New York, N.Y.), 1984, Volume: 4, Issue:4

    Topics: Acetaminophen; Child; Child, Preschool; Fever; Humans

1984
Antipyretic potency of centrally administered alpha-melanocyte stimulating hormone.
    Science (New York, N.Y.), 1983, Jul-08, Volume: 221, Issue:4606

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Dose-Response Rel

1983
[Problems with fever in children].
    Casopis lekaru ceskych, 1983, Jul-08, Volume: 122, Issue:27

    Topics: Acetaminophen; Aspirin; Child; Child, Preschool; Fever; Humans; Infant

1983
House officer management of the febrile child. A survey.
    Clinical pediatrics, 1983, Volume: 22, Issue:11

    Topics: Acetaminophen; Aspirin; Brain Damage, Chronic; Fever; Humans; Infant; Seizures; Surveys and Question

1983
[Acetaminophen poisoning in children: a serious error in medical prescription].
    Boletin medico del Hospital Infantil de Mexico, 1983, Volume: 40, Issue:9

    Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Fever; Humans; Iatro

1983
[Antipyretic effect of an oral solution of paracetamol in children].
    Annales de pediatrie, 1983, Volume: 30, Issue:10

    Topics: Acetaminophen; Administration, Oral; Age Factors; Child; Fever; Humans; Solutions

1983
Pediatric dosing of acetaminophen.
    Pediatric pharmacology (New York, N.Y.), 1983, Volume: 3, Issue:3-4

    Topics: Acetaminophen; Age Factors; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug;

1983
Acetaminophen: a practical pharmacologic overview.
    Canadian Medical Association journal, 1984, Jul-01, Volume: 131, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Child; Child, Preschool; Fever; Humans; Infant; Kidney; Liver; Met

1984
[Antipyretic effect of the oral paracetamol solution in children].
    Annales de pediatrie, 1984, Volume: 31, Issue:4

    Topics: Acetaminophen; Administration, Oral; Child, Preschool; Female; Fever; Humans; Infant; Male

1984
The treatment of fever.
    Journal of the Iowa Medical Society, 1981, Volume: 71, Issue:11

    Topics: Acetaminophen; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans; Salicy

1981
Efficacy, disposition and pharmacodynamics of aspirin, acetaminophen and choline salicylate in young febrile children.
    Therapeutic drug monitoring, 1982, Volume: 4, Issue:2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Choline; D

1982
Why not use acetaminophen for fever?
    Pediatrics, 1982, Volume: 70, Issue:4

    Topics: Acetaminophen; Child; Fever; Humans; Reye Syndrome

1982
Acetaminophen and aspirin. Prescription, use, and accidental ingestion among children.
    American journal of diseases of children (1960), 1982, Volume: 136, Issue:11

    Topics: Acetaminophen; Adolescent; Aspirin; Child; Child, Preschool; Drug Prescriptions; Drug Utilization; F

1982
[Control of hyperthermia in young children with paracetamol oral solution].
    Annales de pediatrie, 1982, Volume: 29, Issue:6

    Topics: Acetaminophen; Administration, Oral; Child; Child, Preschool; Female; Fever; Humans; Male

1982
[Paracetamol, pharmacodynamic, clinical toxicology and pharmacokinetic].
    Medizinische Klinik (Praxis-Ausg.), 1982, Sep-10, Volume: 77, Issue:19

    Topics: Acetaminophen; Dose-Response Relationship, Drug; Fever; Half-Life; Humans; Intestinal Absorption; Ki

1982
Febrile children and antipyretic drugs.
    The Medical journal of Australia, 1982, Sep-18, Volume: 2, Issue:6

    Topics: Acetaminophen; Child; Fever; Home Nursing; Humans

1982
[Comparative study of the antipyretic effect of paracetamol and aminophenazone administered by the rectal route].
    La Clinica terapeutica, 1980, Nov-15, Volume: 95, Issue:3

    Topics: Acetaminophen; Adult; Aminopyrine; Fever; Humans; Rectum; Suppositories

1980
Incorrect dosage of acetaminophen.
    The Journal of pediatrics, 1980, Volume: 97, Issue:1

    Topics: Acetaminophen; Child, Preschool; Fever; Humans; Infant

1980
Risk factors for a first febrile seizure: a matched case-control study.
    Epilepsia, 1995, Volume: 36, Issue:4

    Topics: Acetaminophen; Acute Disease; Case-Control Studies; Comorbidity; Female; Fever; Gastroenteritis; Hum

1995
Paracetamol in childhood illness.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 1995, Volume: 45, Issue:397

    Topics: Acetaminophen; Adolescent; Child; Child, Preschool; Fever; Humans; Infant; Surveys and Questionnaire

1995
[Reduction of antipyretics. A gentler way to reduce fever with lemon compresses along with administration of paracetamol].
    Pflege Zeitschrift, 1995, Volume: 48, Issue:6

    Topics: Acetaminophen; Bandages; Citrus; Fever; Humans

1995
Effect of a standardized rewarming protocol and acetaminophen on core temperature after coronary artery bypass.
    American journal of critical care : an official publication, American Association of Critical-Care Nurses, 1995, Volume: 4, Issue:3

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Body Temperature; Clinical Protocols; Coronary Artery

1995
Fever response to acetaminophen.
    The American journal of emergency medicine, 1995, Volume: 13, Issue:1

    Topics: Acetaminophen; Bacteremia; Child; Cohort Studies; Fever; Humans; Research Design

1995
[Acetaminophen-containing suppositories in vitro and in vivo].
    Acta pharmaceutica Hungarica, 1994, Volume: 64, Issue:2

    Topics: Acetaminophen; Animals; Diffusion; Fever; Male; Rats; Rats, Wistar; Suppositories

1994
[Paracetamol].
    Soins; la revue de reference infirmiere, 1994, Issue:583

    Topics: Acetaminophen; Fever; Humans; Pain

1994
Diagnostic tests for occult bacteremia: temperature response to acetaminophen versus WBC count.
    The American journal of emergency medicine, 1994, Volume: 12, Issue:4

    Topics: Acetaminophen; Bacteremia; Body Temperature; Child; Child, Preschool; Cohort Studies; Emergency Serv

1994
Preischemic hyperglycemia leads to delayed postischemic hyperthermia.
    Stroke, 1994, Volume: 25, Issue:9

    Topics: Acetaminophen; Animals; Body Temperature Regulation; Brain Ischemia; Fever; Glucose; Hypercapnia; Hy

1994
[Reduced erythrocyte glutathione and urinary thioethers in children undergoing treatment with paracetamol].
    Anales espanoles de pediatria, 1993, Volume: 39, Issue:6

    Topics: Acetaminophen; Child; Child, Preschool; Erythrocytes; Female; Fever; Glutathione; Humans; Infant; Ma

1993
Vasopressin release within the ventral septal area of the rat brain during drug-induced antipyresis.
    The American journal of physiology, 1993, Volume: 264, Issue:6 Pt 2

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine Vasopressin; Fever; Indome

1993
Correlating changes in body temperature with infectious outcome in febrile children who receive acetaminophen.
    Clinical pediatrics, 1993, Volume: 32, Issue:6

    Topics: Acetaminophen; Administration, Oral; Age Factors; Bacteremia; Body Temperature; Child, Preschool; Fe

1993
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
    Biochemical pharmacology, 1993, Mar-24, Volume: 45, Issue:6

    Topics: Acetaminophen; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Disease Models, Ani

1993
Is prescribing paracetamol 'pro re nata' acceptable?
    Journal of paediatrics and child health, 1993, Volume: 29, Issue:2

    Topics: Acetaminophen; Child; Child, Preschool; Drug Administration Schedule; Drug Utilization; Fever; Human

1993
Fulminant hepatitis associated with centrilobular hepatic necrosis in young children.
    The Journal of pediatrics, 1995, Volume: 127, Issue:6

    Topics: Acetaminophen; Child, Preschool; Female; Fever; Hepatic Encephalopathy; Humans; Infant; Liver; Male;

1995
Antipyretics induced erythema multiforme.
    Indian pediatrics, 1995, Volume: 32, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Dipyrone; Erythema Multiforme; Fem

1995
Supportive care during aldesleukin therapy for patients infected with human immunodeficiency virus.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1997, May-15, Volume: 54, Issue:10

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antiemetics; Female; Fever; HIV Infections; Humans;

1997
Managing measles. Giving paracetamol for fever is unnecessary.
    BMJ (Clinical research ed.), 1997, Jun-07, Volume: 314, Issue:7095

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Measles

1997
[The physiological properties of the action of a new analgesic and antipyretic preparation].
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 1997, Volume: 43, Issue:1-2

    Topics: Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroid

1997
Over-the-counter medications. Do parents give what they intend to give?
    Archives of pediatrics & adolescent medicine, 1997, Volume: 151, Issue:7

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Child; Female; Fever; Health Education; Humans; Male

1997
Ibuprofen and/or acetaminophen: what price for "euthermia"?
    The Journal of pediatrics, 1997, Volume: 131, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature;

1997
Ibuprofen and/or acetaminophen: what price for "euthermia"?
    The Journal of pediatrics, 1997, Volume: 131, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmac

1997
Rectal paracetamol dosing regimens: determination by computer simulation.
    Paediatric anaesthesia, 1997, Volume: 7, Issue:6

    Topics: Acetaminophen; Administration, Rectal; Adolescent; Analgesics, Non-Narcotic; Biological Availability

1997
[The use of the preparation Solpadeine in dental practice].
    Stomatologiia, 1997, Volume: 76, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caff

1997
Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein induction.
    Toxicology and applied pharmacology, 1997, Volume: 147, Issue:2

    Topics: Acetaminophen; Amphetamine; Animals; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced

1997
[Fatal acute liver damage caused by a therapeutic dose of paracetamol].
    Orvosi hetilap, 1998, Jan-25, Volume: 139, Issue:4

    Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Child, Preschool; Dose-Response R

1998
Variability of concentrations after rectal paracetamol.
    Paediatric anaesthesia, 1998, Volume: 8, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Adult; Analgesics, Non-Narcotic; Child;

1998
Acetaminophen: a clarification.
    The Journal of pediatrics, 1998, Volume: 132, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Huma

1998
Combined antipyretic therapy: another potential source of chronic acetaminophen toxicity.
    The Journal of pediatrics, 1998, Volume: 133, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Chronic Disease; Drug Interactions; Drug Therapy, Co

1998
Reducing temperature in febrile children.
    Annals of tropical paediatrics, 1998, Volume: 18, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Fever; Humans

1998
Paracetamol for fever in children: high time for systematic reviews of the evidence.
    Australian family physician, 1999, Volume: 28, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Evidence-Bas

1999
What we should know about paracetamol.
    Paediatric anaesthesia, 1999, Volume: 9, Issue:4

    Topics: Acetaminophen; Administration, Oral; Administration, Rectal; Analgesics, Non-Narcotic; Blood-Brain B

1999
Parental guidance suggested. Pediatric fever and pain relief require expert input.
    Advance for nurse practitioners, 1999, Volume: 7, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Education; Fever; Humans; Ibuprofe

1999
Antipyretic efficacy of aspirin or acetaminophen.
    Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Drug Storage; Fever; Humans; Lipopolysaccharides;

2000
Toxic epidermal necrolysis associated with acetaminophen ingestion.
    The Annals of pharmacotherapy, 2000, Volume: 34, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Female; Fever; Humans; Stevens-Johnson Syndrome

2000
Physical treatment of fever.
    Archives of disease in childhood, 2000, Volume: 82, Issue:3

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Combined Modality Ther

2000
Parental knowledge of the treatment of fever in children.
    The Israel Medical Association journal : IMAJ, 1999, Volume: 1, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Child; Child, Preschool; Cross-Sectional Studies; Di

1999
[Acetaminophen should remain the first choice drug for the treatment of fever in children].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2000, Volume: 7, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Fever; Humans; Practice Guidelines as Topic

2000
Ibuprofen treatment versus gradual introduction of interferon beta-1b in patients with MS.
    Neurology, 2000, Apr-25, Volume: 54, Issue:8

    Topics: Acetaminophen; Drug Administration Schedule; Fever; Humans; Hypothalamus; Ibuprofen; Interferon beta

2000
Effect of antipyretic therapy on the duration of illness in experimental influenza A, Shigella sonnei, and Rickettsia rickettsii infections.
    Pharmacotherapy, 2000, Volume: 20, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Aspirin; Dysentery, Bacillary; Female; F

2000
Invasive group A streptococcal infection and nonsteroidal antiinflammatory drug use among children with primary varicella.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Case-C

2001
Toxicity of over-the-counter cough and cold medications.
    Pediatrics, 2001, Volume: 108, Issue:3

    Topics: Acetaminophen; Antitussive Agents; Bradycardia; Brompheniramine; Cardiovascular Diseases; Child, Pre

2001
Alternating antipyretics: is this an alternative?
    Pediatrics, 2001, Volume: 108, Issue:5

    Topics: Acetaminophen; Acute Kidney Injury; Analgesics, Non-Narcotic; Cyclooxygenase Inhibitors; Drug Synerg

2001
[Use of alternating antipyretics in the treatment of fever in Spain].
    Anales espanoles de pediatria, 2001, Volume: 55, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Ibuprofen; Infant;

2001
Programmable microchip monitoring of post-stroke pyrexia: effects of aspirin and paracetamol on temperature and infarct size in the rat.
    Journal of neuroscience methods, 2002, Jan-30, Volume: 113, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

2002
Modification of body temperature after acute stroke: a new concept needed?
    Stroke, 2002, Volume: 33, Issue:1

    Topics: Acetaminophen; Acute Disease; Body Temperature; Double-Blind Method; Fever; Humans; Hypothermia; Str

2002
Fever phobia.
    Pediatrics, 2002, Volume: 109, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Attitude to Health; Child; Fever; Humans; Infant; Parents;

2002
PISA. The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: protocol for a phase II double-blind randomised placebo-controlled trial [ISRCTN98608690].
    BMC cardiovascular disorders, 2002, Mar-27, Volume: 2

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Clinical Trials, Phase II

2002
A prospective study of multiple supratherapeutic acetaminophen doses in febrile children.
    Veterinary and human toxicology, 2002, Volume: 44, Issue:2

    Topics: Acetaminophen; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Cohort

2002
Tepid sponging and paracetamol for reduction of body temperature in febrile children.
    The Medical journal of Australia, 2002, Feb-04, Volume: 176, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Baths; Child; Evidence-Based Medicine; Fever; Humans; Treat

2002
Early treatment with intravenous immunoglobulin in patients with Kawasaki disease.
    The Journal of pediatrics, 2002, Volume: 140, Issue:4

    Topics: Acetaminophen; Administration, Oral; Albumins; Analgesics, Non-Narcotic; Aspirin; Canada; Case-Contr

2002
[Severe Reye syndrome: report of 14 cases managed in a pediatric intensive care unit over 11 years].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2002, Volume: 9, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Edema; Child; Child, Preschoo

2002
Oral antipyretic therapy: evaluation of benorylate, an ester of acetylsalicylic acid and paracetamol.
    European journal of pediatrics, 1975, Dec-09, Volume: 121, Issue:1

    Topics: Acetaminophen; Aspirin; Body Temperature; Child; Child, Preschool; Fever; Humans; Infant; Salicylate

1975
Fever and antipyresis in the bluegill sunfish, Lepomis macrochirus.
    Comparative biochemistry and physiology. C: Comparative pharmacology, 1977, Volume: 57, Issue:2

    Topics: Acetaminophen; Aeromonas; Animals; Body Temperature; Body Temperature Regulation; Fever; Fishes

1977
Fever produced in the squirrel monkey by human leukocytic pyrogen.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1979, Volume: 160, Issue:4

    Topics: Acetaminophen; Animals; Fever; Haplorhini; Humans; Injections, Intravenous; Leukocytes; Male; Pyroge

1979
Cyclic adenosine-3',5'-monophosphate in cerebrospinal fluid during fever and antipyresis.
    The Journal of physiology, 1975, Volume: 247, Issue:1

    Topics: Acetaminophen; Animals; Antigens, Bacterial; Cats; Cyclic AMP; Fever; Shigella dysenteriae

1975
Evidence for the involvement of adenosine 3',5'-cyclic monophosphate in fever genesis.
    Pflugers Archiv : European journal of physiology, 1976, Apr-06, Volume: 362, Issue:3

    Topics: Acetaminophen; Animals; Brain; Cyclic AMP; Female; Fever; Hypothalamus; Injections, Intraventricular

1976
Cyclic adenosine 3', 5'-monophosphate in cerebrospinal fluid during thermoregulation and fever.
    The Journal of physiology, 1976, Volume: 263, Issue:3

    Topics: Acetaminophen; Animals; Body Temperature Regulation; Cats; Cold Temperature; Cyclic AMP; Female; Fev

1976
Hyperthermia, antipyretics and function of polymorphonuclear leukocytes.
    Canadian Medical Association journal, 1978, Mar-04, Volume: 118, Issue:5

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Infections; Chemotaxis, Leukocyte;

1978
Antipyretic effect of acetaminophen suppositories in rats.
    Journal of pharmaceutical sciences, 1979, Volume: 68, Issue:9

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Fever; Male; Rats; Rectum; Supposit

1979
[The antipyretic effect of Lonarid N in children].
    Fortschritte der Medizin, 1979, Apr-05, Volume: 97, Issue:13

    Topics: Acetaminophen; Amobarbital; Caffeine; Child; Child, Preschool; Codeine; Drug Combinations; Drug Eval

1979
Hyperthermia and rhabdomyolysis in self-poisoning with paracetamol and salicylates. Report of a case.
    Acta medica Scandinavica, 1979, Volume: 205, Issue:6

    Topics: Acetaminophen; Adult; Female; Fever; Humans; Muscles; Muscular Diseases; Myoglobinuria; Necrosis; Sa

1979
Antipyretic effect and plasma concentrations of rectal acetaminophen and diazepam in children.
    Epilepsia, 1979, Volume: 20, Issue:6

    Topics: Acetaminophen; Body Temperature; Child; Child, Preschool; Diazepam; Drug Therapy, Combination; Fever

1979
Increase in body temperature during carrageenin-induced paw oedema in the rat. Effect of non-steroid anti-inflammatory substances and essential fatty acid deficiency.
    Prostaglandins and medicine, 1979, Volume: 2, Issue:5

    Topics: Acetaminophen; Aging; Animals; Anti-Inflammatory Agents; Brain Chemistry; Carrageenan; Edema; Fatty

1979
Oral antipyretic therapy. Evaluation of mefenamic acid (short communication).
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:3

    Topics: Acetaminophen; Adolescent; Aminopyrine; Aspirin; Child; Child, Preschool; Drug Evaluation; Fever; Hu

1977
[Investigations concerning temperature and serum concentrations of paracetamol in febrile infants following rectal application of paracetamol (author's transl)].
    Padiatrie und Padologie, 1978, Volume: 13, Issue:1

    Topics: Acetaminophen; Body Temperature; Child, Preschool; Fever; Humans; Infant; Rectum; Suppositories; Tim

1978
Effects of hyperbaric helium-oxygen on the antipyretic actions of aspirin and acetaminophen in rats.
    Undersea biomedical research, 1978, Volume: 5, Issue:1

    Topics: Acetaminophen; Animals; Aspirin; Atmospheric Pressure; Fever; Helium; Hyperbaric Oxygenation; Oxygen

1978
[Symptomatic antipyretic and analgesic treatment with Verlapyrin in children].
    Therapie der Gegenwart, 1978, Volume: 117, Issue:10

    Topics: Acetaminophen; Child; Child, Preschool; Diphenhydramine; Drug Combinations; Drug Evaluation; Fever;

1978
[Clinical effect of rectal application of paracetamol in childhood (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1977, Mar-01, Volume: 66, Issue:9

    Topics: Acetaminophen; Body Temperature; Child; Child, Preschool; Fever; Humans; Infant; Suppositories

1977
Oral antipyretic therapy.
    Scandinavian journal of rheumatology, 1976, Volume: 5, Issue:2

    Topics: Acetaminophen; Administration, Oral; Aminopyrine; Aspirin; Child; Child, Preschool; Drug Evaluation;

1976
Antagonism by antipyretics of the hyperthermic effect of a prostaglandin precursor, sodium arachidonate, in the cat.
    The Journal of physiology, 1976, Volume: 257, Issue:3

    Topics: Acetaminophen; Analgesics; Animals; Arachidonic Acids; Body Temperature; Cats; Fever; Indomethacin;

1976
[Investigations concerning serum concentration and temperature following oral application of a new paracetamol preparation (author's transl)].
    Klinische Padiatrie, 1976, Volume: 188, Issue:5

    Topics: Acetaminophen; Body Temperature; Child; Child, Preschool; Fever; Humans; Infant

1976
Acetaminophen toxicosis in the cat.
    Journal of the American Veterinary Medical Association, 1975, Mar-01, Volume: 166, Issue:5

    Topics: Acetaminophen; Administration, Oral; Anemia; Animals; Bilirubin; Blood Urea Nitrogen; Cat Diseases;

1975
Prostaglandins, endotoxin and lipid A on body temperature in rats.
    The Journal of physiology, 1975, Volume: 249, Issue:3

    Topics: Acetaminophen; Animals; Body Temperature; Cerebral Ventricles; Endotoxins; Female; Fever; Indomethac

1975
Fever in childhood.
    The Journal of family practice, 1976, Volume: 3, Issue:1

    Topics: Acetaminophen; Aspirin; Child; Fever; Humans

1976
Diencephalic efflux of 22Na+ and 45Ca2+ ions in the febrile cat: effect of an antipyretic.
    Brain research, 1976, Feb-20, Volume: 103, Issue:2

    Topics: Acetaminophen; Animals; Calcium; Cats; Diencephalon; Female; Fever; Hypothermia; Male; Pyrogens; Sal

1976
[Monotherapy and treatment of fever in children].
    Archives francaises de pediatrie, 1992, Volume: 49, Issue:8

    Topics: Acetaminophen; Aspirin; Child; Drug Administration Schedule; Fever; Humans

1992
Drugs for childhood fever.
    Lancet (London, England), 1992, Jan-04, Volume: 339, Issue:8784

    Topics: Acetaminophen; Child; Contraindications; Fever; Humans; Ibuprofen

1992
[Is the use of antipyretics justified in lowering fever and preventing febrile convulsions in children?].
    Nederlands tijdschrift voor geneeskunde, 1992, Oct-24, Volume: 136, Issue:43

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans; Seizures, Febrile

1992
[A combination of two antipyretic agents, is it adequate for the treatment of hyperthermia in pediatric patients?].
    Archives francaises de pediatrie, 1992, Volume: 49, Issue:4

    Topics: Acetaminophen; Age Factors; Aspirin; Child; Drug Therapy, Combination; Fever; Humans

1992
Single-dose pharmacokinetics of ibuprofen and acetaminophen in febrile children.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:3

    Topics: Acetaminophen; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedu

1992
Antipyretics in febrile children.
    Lancet (London, England), 1991, Apr-27, Volume: 337, Issue:8748

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans

1991
Management of childhood fever.
    Lancet (London, England), 1991, Oct-26, Volume: 338, Issue:8774

    Topics: Acetaminophen; Child; Fever; Humans; Ibuprofen

1991
Management of childhood fever.
    Lancet (London, England), 1991, Nov-30, Volume: 338, Issue:8779

    Topics: Acetaminophen; Aspirin; Child; Fever; Humans; Ibuprofen

1991
[The treatment of a high fever in young children at the prehospital stage].
    Pediatriia, 1991, Issue:8

    Topics: Acetaminophen; Acute Disease; Combined Modality Therapy; Communicable Diseases; Cryotherapy; Dipyron

1991
Appropriate dosage of acetominophen for infants.
    Journal of emergency nursing, 1991, Volume: 17, Issue:3

    Topics: Acetaminophen; Body Weight; Fever; Humans; Infant; Infant, Newborn; Reference Books, Medical

1991
Guidelines for the care of children and adolescents with HIV infection. Management of the HIV-positive child with fever.
    The Journal of pediatrics, 1991, Volume: 119, Issue:1 Pt 2

    Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Child; Fever; HIV Infections; HIV Seropositivity;

1991
[Antipyretic therapy in pediatrics].
    Ceskoslovenska pediatrie, 1990, Volume: 45, Issue:10

    Topics: Acetaminophen; Aspirin; Child; Child, Preschool; Fever; Humans; Infant

1990
[Antipyretic action of aniline derivatives in rats during different parts of the day].
    Folia medica Cracoviensia, 1990, Volume: 31, Issue:4

    Topics: Acetaminophen; Animals; Circadian Rhythm; Fever; Male; Phenacetin; Phenetidine; Rats; Rats, Inbred S

1990
[Paralen suppositories for children--a new therapeutic form of antipyretic].
    Ceskoslovenska pediatrie, 1990, Volume: 45, Issue:4

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans; Suppositories

1990
Efficacy of sponging vs. acetaminophen for reduction of fever.
    Pediatric emergency care, 1990, Volume: 6, Issue:3

    Topics: Acetaminophen; Baths; Child; Fever; Humans

1990
Antipyretic orders in a university hospital.
    The American journal of medicine, 1990, Volume: 88, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool;

1990
[Use of acetaminophen in the community].
    Harefuah, 1990, Jan-01, Volume: 118, Issue:1

    Topics: Acetaminophen; Child, Preschool; Dosage Forms; Drug Administration Schedule; Fever; Health Education

1990
Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis.
    Journal of applied physiology (Bethesda, Md. : 1985), 1990, Volume: 68, Issue:5

    Topics: Acetaminophen; Animals; Arginine Vasopressin; Brain; Endotoxins; Fever; Male; Rats; Rats, Inbred Str

1990
Efficacy of sponging vs. acetaminophen for reduction of fever.
    Pediatric emergency care, 1990, Volume: 6, Issue:2

    Topics: Acetaminophen; Baths; Child; Fever; Humans

1990
Dangers from use of paracetamol.
    The New Zealand medical journal, 1990, Aug-22, Volume: 103, Issue:896

    Topics: Acetaminophen; Child; Fever; Humans

1990
Using acetaminophen in infants.
    American pharmacy, 1990, Volume: NS30, Issue:8

    Topics: Acetaminophen; Bacterial Infections; Fever; Humans; Infant

1990
Trends in the incidence of Reye's syndrome and the use of aspirin.
    Archives of disease in childhood, 1990, Volume: 65, Issue:8

    Topics: Acetaminophen; Aspirin; Child; Child, Preschool; Female; Fever; Humans; Incidence; Infant; Male; Rey

1990
Antipyretic effect of central alpha-MSH summates with that of acetaminophen or ibuprofen.
    Brain research bulletin, 1989, Volume: 23, Issue:6

    Topics: Acetaminophen; alpha-MSH; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Femal

1989
Ibuprofen vs acetaminophen in children.
    The Medical letter on drugs and therapeutics, 1989, Dec-15, Volume: 31, Issue:807

    Topics: Acetaminophen; Child; Drug Overdose; Fever; Humans; Ibuprofen; Pain; Suspensions

1989
[Paracetamol].
    Krankenpflege Journal, 1989, Apr-01, Volume: 27, Issue:4

    Topics: Acetaminophen; Fever; Humans; Pain

1989
Severity of disease correlated with fever reduction in febrile infants.
    Pediatrics, 1989, Volume: 83, Issue:6

    Topics: Acetaminophen; Body Temperature; Fever; Haemophilus Infections; Haemophilus influenzae; Humans; Infa

1989
Ibuprofen: an alternative for children's fevers.
    The American journal of nursing, 1989, Volume: 89, Issue:11

    Topics: Acetaminophen; Child; Child, Preschool; Fever; Humans; Ibuprofen

1989
Paracetamol suppositories: a comparative study.
    Archives of disease in childhood, 1989, Volume: 64, Issue:10

    Topics: Acetaminophen; Adolescent; Child; Child, Preschool; Fever; Humans; Infant; Postoperative Complicatio

1989
Fever. What to do and what not to do.
    Postgraduate medicine, 1988, Volume: 83, Issue:8

    Topics: Acetaminophen; Acute-Phase Reaction; Aspirin; Body Temperature Regulation; Cold Temperature; Fever;

1988
Paracetamol for fever in children.
    Australian family physician, 1988, Volume: 17, Issue:9

    Topics: Acetaminophen; Drug Administration Schedule; Fever; Humans

1988
Are we sweeping DTP contraindications under the rug?
    American journal of diseases of children (1960), 1988, Volume: 142, Issue:7

    Topics: Acetaminophen; Child; Diphtheria Toxoid; Diphtheria-Tetanus-Pertussis Vaccine; Drug Combinations; Fe

1988
FS 205-397: a new antipyretic analgesic with a paracetamol-like profile of activity but lack of acute hepatotoxicity in mice.
    Life sciences, 1988, Volume: 43, Issue:11

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Infectious; Disease Mode

1988
Influence of ascorbic acid esters on acetaminophen-induced hepatotoxicity in mice.
    Toxicology letters, 1988, Volume: 44, Issue:1-2

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Body Weight; Drug Th

1988
Acetaminophen (paracetamol) in the management of burned children with fever.
    Burns, including thermal injury, 1988, Volume: 14, Issue:5

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Burns; Child, Preschool; Female; Fever; Huma

1988
Preadmission antipyretics in Reye's syndrome.
    Archives of disease in childhood, 1988, Volume: 63, Issue:7

    Topics: Acetaminophen; Adolescent; Aspirin; Child; Child, Preschool; Fever; Hospitalization; Humans; Infant;

1988
Eugenol: antipyretic activity in rabbits.
    Neuropharmacology, 1987, Volume: 26, Issue:12

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; E

1987
Childhood fever: correlation of diagnosis with temperature response to acetaminophen.
    Pediatrics, 1987, Volume: 80, Issue:3

    Topics: Acetaminophen; Bacterial Infections; Body Temperature; Child; Child, Preschool; Drug Evaluation; Fem

1987
Underdosing of acetaminophen by parents.
    Pediatrics, 1987, Volume: 80, Issue:5

    Topics: Acetaminophen; Age Factors; Body Weight; Child, Preschool; Fever; Humans; Infant; Medication Errors;

1987
Effect of febrile illness and its treatment on anticonvulsant levels in children.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1986, Jun-15, Volume: 134, Issue:12

    Topics: Acetaminophen; Anti-Bacterial Agents; Anticonvulsants; Child; Drug Interactions; Fever; Humans; Kine

1986
Use of aspirin and Reye's syndrome.
    American journal of diseases of children (1960), 1987, Volume: 141, Issue:3

    Topics: Acetaminophen; Aspirin; Child; Fever; Humans; Reye Syndrome

1987
Temperature response to antipyretic therapy in children: relationship to occult bacteremia.
    The American journal of emergency medicine, 1985, Volume: 3, Issue:3

    Topics: Acetaminophen; Aspirin; Body Temperature; Child, Preschool; Fever; Haemophilus Infections; Haemophil

1985
Fever: to treat or not to treat.
    Rational drug therapy, 1985, Volume: 19, Issue:12

    Topics: Acetaminophen; Aspirin; Child; Fever; Humans; Ibuprofen; Interleukin-1; Reye Syndrome

1985
Decreasing trends in Reye syndrome and aspirin use in Michigan, 1979 to 1984.
    Pediatrics, 1986, Volume: 77, Issue:1

    Topics: Acetaminophen; Aspirin; Child; Common Cold; Fever; Humans; Michigan; Reye Syndrome

1986
Kawasaki disease: review of risk factors for coronary aneurysms.
    The Journal of pediatrics, 1986, Volume: 108, Issue:3

    Topics: Acetaminophen; Age Factors; Aneurysm; Child; Child, Preschool; Coronary Disease; Female; Fever; Huma

1986
Evaluation of sponging to reduce body temperature in febrile children.
    Canadian Medical Association journal, 1985, Mar-15, Volume: 132, Issue:6

    Topics: Acetaminophen; Aspirin; Baths; Child, Preschool; Fever; Humans; Infant; Male

1985
Antipyretic use among children during the 1983 influenza season.
    American journal of diseases of children (1960), 1985, Volume: 139, Issue:5

    Topics: Acetaminophen; Adolescent; Adult; Aspirin; Chickenpox; Child; Child, Preschool; Female; Fever; Healt

1985
[Fever in the infant].
    Archives francaises de pediatrie, 1985, Volume: 42, Issue:1

    Topics: Acetaminophen; Aspirin; Body Temperature; Body Temperature Regulation; Drug Therapy, Combination; Fe

1985
Absence of a pharmacokinetic interaction between chloramphenicol and acetaminophen in children.
    The Journal of pediatrics, 1985, Volume: 107, Issue:1

    Topics: Acetaminophen; Age Factors; Body Temperature; Child, Preschool; Chloramphenicol; Chromatography, Hig

1985
Treatment of fever in burned children. A therapeutic program.
    Clinical pediatrics, 1973, Volume: 12, Issue:6

    Topics: Acetaminophen; Adrenergic alpha-Antagonists; Burns; Child; Child, Preschool; Chlorpromazine; Fever;

1973
Further studies on the role of prostaglandin in fever.
    The Journal of physiology, 1974, Volume: 241, Issue:3

    Topics: Acetaminophen; Animals; Body Temperature; Calcium; Cats; Cerebral Ventricles; Cerebrospinal Fluid; C

1974
The hyperthermic effect of intracerebroventricular cholera enterotoxin in the unanaesthetized cat.
    The Journal of physiology, 1974, Volume: 240, Issue:2

    Topics: Acetaminophen; Animals; Body Temperature; Bucladesine; Cats; Cerebral Ventricles; Consciousness; Cyc

1974
[Paidipyrin--a phenacetin free antipyretic for children].
    Medizinische Monatsschrift, 1967, Volume: 21, Issue:11

    Topics: Acetaminophen; Analgesics; Child; Child, Preschool; Fever; Humans; Infant; Urea

1967
[Antipyresis in pediatrics].
    Monatsschrift fur Kinderheilkunde, 1972, Volume: 120, Issue:5

    Topics: Acetaminophen; Analgesics; Child, Preschool; Diphenylacetic Acids; Drug Combinations; Fever; Humans;

1972
Proceedings: Lipid A and prostaglandin.
    The Journal of physiology, 1974, Volume: 239, Issue:2

    Topics: Acetaminophen; Animals; Aspirin; Cats; Endotoxins; Fever; Indomethacin; Lipids; Prostaglandins

1974
Pyrogen fever and prostaglandin-like activity in cerebrospinal fluid.
    The Journal of physiology, 1973, Volume: 228, Issue:1

    Topics: Acetaminophen; Animals; Antigens, Bacterial; Biological Assay; Body Temperature; Cats; Fever; Lyserg

1973
Effect of pyrogen and antipyretics on prostaglandin acitvity in cisternal c.s.f. of unanaesthetized cats.
    The Journal of physiology, 1973, Volume: 234, Issue:2

    Topics: Acetaminophen; Animals; Aspirin; Body Temperature; Cats; Cerebral Ventricles; Chromatography, Thin L

1973
[Clinical experiences with a new analgetic-antipyretic drug combination in pediatrics].
    Medizinische Klinik, 1973, Jan-26, Volume: 68, Issue:4

    Topics: Acetaminophen; Child; Child, Preschool; Dextropropoxyphene; Drug Combinations; Fever; Humans; Infant

1973
Q fever.
    British medical journal, 1973, Apr-07, Volume: 2, Issue:5857

    Topics: Acetaminophen; Animals; Aspirin; Cattle; Coxiella; Disease Reservoirs; Feces; Fever; Headache; Human

1973
Arthralgia and myalgia in mumps.
    Rheumatology and rehabilitation, 1973, Volume: 12, Issue:2

    Topics: Acetaminophen; Adult; Arthritis; Blood Cell Count; Fever; Hematocrit; Hemoglobins; Humans; Male; Mum

1973
[Clinical evaluation of the antipyretic activity of 4-prenyl-1,2-diphenyl-3,5-pyrazolidindione in pediatrics].
    Minerva pediatrica, 1974, Mar-24, Volume: 26, Issue:10

    Topics: Acetaminophen; Analgesics; Child; Child, Preschool; Female; Fever; Gastroenteritis; Humans; Infant;

1974
ORAL ANTIPYRETIC THERAPY. Evaluation of aspirin-acetaminophen combination.
    American journal of diseases of children (1960), 1972, Volume: 123, Issue:3

    Topics: Acetaminophen; Administration, Oral; Aspirin; Child, Preschool; Drug Combinations; Female; Fever; Hu

1972
Inhibition of leukocytic pyrogen-induced fever by intracerebroventricular administration of salicylate and acetaminophen in the cat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 140, Issue:2

    Topics: Acetaminophen; Animals; Ascitic Fluid; Cats; Cerebral Ventricles; Fever; Injections; Leukocytes; Met

1972
Oral antipyretic therapy.
    American journal of diseases of children (1960), 1972, Volume: 124, Issue:3

    Topics: Acetaminophen; Administration, Oral; Aspirin; Drug Synergism; Fever; Humans; Time Factors

1972
The effect of different environmental temperatures on the hyperpyrexia produced by the intraventricular injection of pyrogen, 5-hydroxytryptamine and prostaglandin E 1 in the conscious cat.
    Journal de physiologie, 1971, Volume: 63, Issue:3

    Topics: Acetaminophen; Animals; Body Temperature Regulation; Cats; Fever; Prostaglandins; Pyrogens; Serotoni

1971
Fever responses to bacterial pyrogens in guinea pigs and application for screening of antipyretic agents.
    Japanese journal of pharmacology, 1968, Volume: 18, Issue:1

    Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Body Temperature; Female; Fever; Flufenami

1968
The antipyretic effects of acetaminophen and sodium salicylate on endotoxin-induced fevers in cats.
    The Journal of pharmacology and experimental therapeutics, 1970, Volume: 175, Issue:2

    Topics: Acetaminophen; Animals; Cats; Endotoxins; Fever; Injections, Intravenous; Salmonella typhi; Sodium S

1970
[Antipyretic effect of togal suppositories for children].
    Medizinische Monatsschrift, 1970, Volume: 24, Issue:7

    Topics: Acetaminophen; Analgesics; Child; Child, Preschool; Fever; Humans; Quinine; Salicylamides; Supposito

1970
Pyrexial reactions during haemodialysis.
    British medical journal, 1971, Mar-06, Volume: 1, Issue:5748

    Topics: Acetaminophen; Albumins; Blood; Codeine; Diazepam; Female; Fever; Humans; Kidneys, Artificial; Male;

1971
Seizures and fever.
    Postgraduate medicine, 1971, Volume: 50, Issue:1

    Topics: Acetaminophen; Acidosis, Respiratory; Age Factors; Alkalosis, Respiratory; Aspirin; Brain Diseases;

1971
The assay of anti-pyretic drugs in mice, using intracerebral injection of pyretogenins.
    British journal of pharmacology, 1968, Volume: 34, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Aspirin; Biological Assay; Body Temperature; Cerebra

1968
The effect of 4-acetamidophenol in reducing fever produced by the intracerebral injection of 5-hydroxytryptamine and pyrogen in the conscious cat.
    British journal of pharmacology, 1968, Volume: 34, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Cats; Cerebral Ventricles; Fever; Injections; Injections, Intrap

1968
[Report of experimentation with febrectol].
    Semaine therapeutique, 1965, Volume: 41, Issue:10

    Topics: Acetaminophen; Adult; Aged; Female; Fever; Humans; Male; Middle Aged; Phenobarbital; Respiratory Tra

1965