acetaminophen has been researched along with Experimental Hepatoma in 18 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Rats were initially given a single ip injection of diethylnitrosamine (200 mg/kg body weight) and fed basal diet containing 0." | 3.67 | Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis. ( Inoue, K; Ito, N; Masui, T; Ogiso, T; Tsuda, H, 1986) |
| " In contrast, only DEHP and BBS induced toxic renal lesions." | 1.27 | The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car ( Anderson, LM; Diwan, BA; Hagiwara, A; Lindsey, K; Ward, JM, 1988) |
| "0% dosage level, 20% of rats of both sexes developed neoplastic nodules of the liver, a statistically significant incidence." | 1.27 | Induction by paracetamol of bladder and liver tumours in the rat. Effects on hepatocyte fine structure. ( Flaks, A; Flaks, B; Shaw, AP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (55.56) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, X | 1 |
| Li, L | 1 |
| Sun, H | 1 |
| Zhang, F | 1 |
| Li, C | 1 |
| Li, F | 1 |
| Wang, H | 1 |
| Li, B | 1 |
| Chen, R | 1 |
| Kang, J | 1 |
| Singh, Y | 1 |
| Braeuning, A | 1 |
| Schmid, A | 1 |
| Pichler, BJ | 1 |
| Schwarz, M | 1 |
| Wan, XY | 1 |
| Luo, M | 1 |
| Li, XD | 1 |
| He, P | 1 |
| Farombi, EO | 1 |
| Nwankwo, JO | 1 |
| Emerole, GO | 1 |
| Elliott, WL | 1 |
| Sawick, DP | 1 |
| DeFrees, SA | 1 |
| Heinstein, PF | 1 |
| Cassady, JM | 1 |
| Morré, DJ | 1 |
| Dybing, E | 1 |
| Holme, JA | 1 |
| Gordon, WP | 1 |
| Søderlund, EJ | 1 |
| Dahlin, DC | 1 |
| Nelson, SD | 1 |
| Flaks, A | 2 |
| Flaks, B | 2 |
| Bolanowska, W | 1 |
| Gessner, T | 1 |
| Uehara, H | 1 |
| Otsuka, H | 1 |
| Izumi, K | 1 |
| Hasegawa, R | 2 |
| Takahashi, S | 1 |
| Imaida, K | 1 |
| Yamaguchi, S | 1 |
| Shirai, T | 1 |
| Ito, N | 4 |
| Holmes, EH | 1 |
| Maruyama, H | 1 |
| Takashima, Y | 1 |
| Murata, Y | 1 |
| Nakae, D | 1 |
| Eimoto, H | 1 |
| Tsutsumi, M | 1 |
| Denda, A | 1 |
| Konishi, Y | 1 |
| Kurata, Y | 2 |
| Tsuda, H | 3 |
| Tamano, S | 1 |
| Masui, T | 1 |
| Inoue, K | 1 |
| Ogiso, T | 1 |
| Ward, JM | 1 |
| Hagiwara, A | 1 |
| Anderson, LM | 1 |
| Lindsey, K | 1 |
| Diwan, BA | 1 |
| Furukawa, F | 1 |
| Toyoda, K | 1 |
| Jang, JJ | 1 |
| Yamashita, K | 1 |
| Sato, S | 1 |
| Takahashi, M | 1 |
| Hayashi, Y | 1 |
| Sakata, T | 1 |
| Yamashita, T | 1 |
| Shaw, AP | 1 |
18 other studies available for acetaminophen and Experimental Hepatoma
| Article | Year |
|---|---|
Eight new glycosides with hepatoprotective activity isolated from the aerial parts of Morinda parvifolia.
Topics: Acetaminophen; Animals; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Drug Sc | 2019 |
Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen.
Topics: Acetaminophen; Animals; beta Catenin; Carcinogens; Cell Proliferation; Cytochrome P-450 CYP2E1; Diet | 2013 |
Hepatoprotective and anti-hepatocarcinogenic effects of glycyrrhizin and matrine.
Topics: Acetaminophen; Alkaloids; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chlorides | 2009 |
The effect of modulation of glutathione levels on markers for aflatoxin B1-induced cell damage.
Topics: Acetaminophen; Aflatoxin B1; Animals; Biomarkers; Glutathione; Glutathione Transferase; Lipid Peroxi | 2005 |
Cyclic modulation of enzymes of pyrimidine nucleotide biosynthesis precedes sialoglycoconjugate changes during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Carbon-Nitrogen Ligases; Dihydroorotate Oxidase; Liga | 1984 |
Genotoxicity studies with paracetamol.
Topics: Acetaminophen; Animals; Chemical Phenomena; Chemistry; DNA; DNA Repair; Isoenzymes; L-Lactate Dehydr | 1984 |
Induction of liver cell tumours in IF mice by paracetamol.
Topics: Acetaminophen; Animals; Carcinogens; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains | 1983 |
Drug interactions with acetaminophen: effects of phenobarbital, prednisone and 5-fluorouracil in normal and tumor-bearing rats.
Topics: Acetaminophen; Animals; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Galactosamine; I | 1980 |
Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-St | 1999 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
GDP-fucose:GM1 alpha 1----2fucosyltransferase is activated in parenchymal cells of rat liver during early stages of N-2-acetylaminofluorene induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Biomarkers, Tumor; Carbohydrate Sequence; Enzyme Acti | 1990 |
Lack of hepatocarcinogenic potential of acetaminophen in rats with liver damage associated with a choline-devoid diet.
Topics: Acetaminophen; Animals; Body Weight; Carcinogens; Choline Deficiency; Diethylnitrosamine; Female; Gl | 1990 |
Inhibitory potential of acetaminophen and o-, m-, p- aminophenols for development of gamma-glutamyltranspeptidase-positive liver cell foci in rats pretreated with diethylnitrosamine.
Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Diethylnitrosamine; gamma-Glutamyltransferase; Li | 1985 |
Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aniline Compounds; Animals; Body Weight; Butylated Hydroxyanis | 1986 |
The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car
Topics: Acetaminophen; Animals; Autoradiography; Barbital; Barbiturates; Diethylhexyl Phthalate; DNA; Immuno | 1988 |
Study for tumor-initiating effect of acetaminophen in two-stage liver carcinogenesis of male F344 rats.
Topics: Acetaminophen; Animals; Body Weight; Cocarcinogenesis; DNA; Glutathione Transferase; Liver; Liver Ne | 1988 |
Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.
Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Diethylnitrosamine; Glutathione Transferase; Kidn | 1987 |
Induction by paracetamol of bladder and liver tumours in the rat. Effects on hepatocyte fine structure.
Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Liver; Live | 1985 |